Genentech takes the health and safety of our patients, customers, employees and local communities very seriously, and we are actively responding to the global COVID-19 pandemic. For more, please visit our COVID-19 response page or call 1-877-436-3683.

Scientist, Macrocycle Discovery Group, Early Discovery Biochemistry

South San Francisco, California

Return to Search Results

The Position

An opportunity for a creative, talented and highly motivated Scientist is available in the Department of Early Discovery Biochemistry. The successful candidate will join a dynamic and cross-functional group pursuing peptide drug discovery and development, with a focus on discovering and developing macrocyclic peptides as a next-generation imaging and cell-profiling modality. This work will contribute to the development of our cutting-edge automated macrocycle discovery platform to enable the robust discovery of lead-like molecules and will require direct collaboration with diverse therapeutic functions across Genentech including Pathology, Biomedical Imaging, and Cellular and Tissue Genomics.

The successful candidate is expected to contribute to the discovery and optimization of macrocyclic peptides against targets of therapeutic interest and to characterize their mechanism of action using biochemical, biophysical, and structural biology methods. The candidate is also expected to contribute at a strategic level to support therapeutic macrocycle lead discovery programs. The candidate is expected to present their findings to project teams and senior management, as well as externally through journal publications and conference presentations.


  • Ph.D. in Biochemistry, Biophysics, Chemistry, Chemical Biology or related discipline, with at least 2 years of relevant post-doctoral or industry experience
  • Self-driven and highly motivated with a passion for discovery and innovation
  • Deep knowledge and hands-on experience with peptide chemistry, protein engineering, biophysics, structural biology, and molecular biology
  • Experience in display technologies (phage, yeast, or mRNA), small-or large-molecule screening and assay technologies, and/or optical or other imaging methods is desirable
  • Rigorous analytical and quantitative problem solving  
  • Multitasking, and organizational skills, with an ability to prioritize effectively to deliver results within established timelines
  • Excellent interpersonal skills with demonstrated ability to work within a diverse team
  • Excellent mentoring skills across all levels
  • Outstanding communication skills, both orally and in writing
  • Sustained record of productivity and substantive scientific contributions as evidenced by high-impact publications, patent inventorship, and/or external presentations.


Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

Return to Search Results

Join our Talent Community. By joining our Talent Community, your resume will be available to our recruitment team, Join today!