Job Search

The Position:

The technical onsite support lead position is responsible for overseeing, planning and successful delivery of the IT services at the Genentech Access Solutions site in Portland. This position is based in Portland, Oregon and reports to the IT Manager of Onsite Support in South San Francisco, CA.

Job Responsibilities:

• Act as site team lead for IT efforts onsite, while collaborating with, and overseeing the work of, other potential FTEs & contingent/contract workforce members at the site. Work involves:
  • Hands on deskside support to all users for Multiple enterprise/departmental applications, Various computer platforms and hardware/software, including but not limited to: Windows, Macintosh OSX, iOS devices, tablets, desktops, laptops, AV conferencing and printing solutions, Call Center Technology and software, etc.
  • Change agent (training and communication) for all workplace technology solutions
  • Point of contact for ensuring infrastructure (Network, Data Center Administration) is working as designed and meeting SLA expectations.
  • Primary technical point of escalation for all technology issues for the site.
• Collaborate with End User Computing Service Owner to enable feedback channel for strategic and operational needs for Portland site. Help business groups plan and deliver for future growth of the site. Provide recommendations and develop implementation plans to optimize service availability and improve user experience
• Collaborate with global teams, provide recommendations and develop implementation plans to optimize service availability and improve user experience
• Ensures computer equipment (laptops/desktops/Mobile devices/etc.), hardware (multi-function devices etc.), and software (Adobe, Microsoft etc.) are available to meet organizational needs and drive towards Day 1 productivity for onboarding
• Engage with business stakeholder teams to establish user experience index score, ensure customer service is timely, set specific customer service standards and SLA’s for service teams.
• Follow ITSM processes, review service trends, identify opportunities, perform root cause analysis and implement corrective/preventative actions (self-healing, self-serve etc.) to improve service availability and increase productivity for users
• Define, plan, direct the establishment & execution of a broad range of medium to complex technical programs/projects, while balancing the competing demands of scope, time, cost, quality, resources and risk. Formulate risk mitigation strategies and recommend solutions
• Develop technical solutions to a wide range of difficult problems - solutions should be imaginative, thorough, practicable, and consistent with organizational objectives
• Mentor, train, and develop peers & junior technicians within the organization, Document & communicate resolutions, workarounds, and FAQs (via knowledge management solution articles and other available channels).

Requirements:

• Bachelor’s Degree in Computer Science, Information Technology, or other relevant field preferred
• Minimum of 4+ years of Technical Support Lead experience and 2+ years of tier 2/3 Desktop Support experience
• Demonstrated experience as technical lead for multiple implementations, upgrades, deployments and/or migrations & has experience supporting virtual environments
• Advanced technical experience supporting Windows, Mac, iOS devices, call center technology, UNIX, Google suite of products (gMail, gCalendar, gDrive, etc.) and network concepts and troubleshooting tools (TCP/IP, remote access solutions, network file shares, tracert, netstat, etc.)
• Comprehensive understanding of Active Directory & Group Policy Management
• Detailed understanding of, and expert experience with: data analysis, deployments, cloud-based platforms, information security, SCCM, desktop infrastructure, software packaging and distribution, patch management, etc.
• MCITP, MCDST, ACSP, A+ and other ITIL Certifications preferred
• Well-versed in ITIL core processes:  Incident Management (IM), Request Management (RM), and Knowledge Management (KM), Experience with Service Now is a plus
• Advanced knowledge of Linux, PowerShell scripting, queries and reporting, VMWare, and Citrix is a plus
• Business travel will occasionally be required

Knowledge, Skills & Abilities:

• Strategic agility – link individual accountabilities with the mission of the organization; focus on activities that add the most value 
• Able to represent manager in meetings and make decisions related to areas of subject matter expertise
• Outstanding business partnership, customer service and interpersonal skills
• Proven leadership skills and the ability to govern a small team effectively
• Communicates clearly with technical and non-technical audiences, both verbally and written
• Strong organizational and multi-tasking skills, along with the ability to prioritize tasks among many competing requests
• Strong analytical skills for effective troubleshooting and problem solving
• Expertise in numerous technologies
• Able to organize and frame appropriate timelines to meet delivery goals
• Ability to work in a team environment or independently

The Senior Compliance Specialist or Principal Compliance Specialist (Healthcare Compliance) is a member of the U.S. Medical Affairs Compliance (gMAC) team and is responsible for working closely with other members of gMAC, U.S. Medical Affairs functions, and other compliance teams (i.e., Healthcare Compliance Office (HCO), Commercial Business Operations, Global Product Strategy, Group Audit and Risk Advisory, etc.) on healthcare compliance and corporate compliance activities that impact U.S. Medical Affairs.  The Senior Compliance Specialist or Principal Compliance Specialist (Healthcare Compliance) develops Medical Affairs procedures that are aligned with global and local regulations and policies, monitoring strategies for U.S. Medical Affairs, and ensures communication regarding compliance throughout the U.S. Medical Affairs organization.

The mission of gMAC is to advance the health and success of the organization by helping the U.S. Medical Affairs team navigate effectively through the evolving compliance environment. gMAC achieves this mission by representing the unique perspectives of the organization, offering business direction to foster the internal uptake and implementation of compliance, quality, and regulatory changes, and facilitating interactions with key partners across the organization. gMAC works in close coordination with and advice from the organization’s legal and compliance functions.

gMAC is responsible for providing further business direction to U.S. Medical Affairs staff through the development of business-facing process documents (i.e., standard operating procedures [SOPs], working documents, job aids, etc.) and ensuring U.S. Medical Affairs staff understands how to apply corporate and global policies and processes.  The function also ensures U.S. Medical Affairs is in compliance through proactive selected monitoring and improvement efforts, and understanding audit results and deploying needed corrective actions. These business-facing activities are done with close coordination with and advice from the respective legal and compliance functions.

Core Responsibilities:

• Understands the Genentech organization, particularly corporate and U.S. Medical Affairs policies and guidelines, as well as U.S. Medical Affairs organizational dynamics.
• Partners with the business to develop and maintain U.S. Medical Affairs and business-facing SOPs, working documents, job aids, etc.
• Provides compliance subject matter expertise to the U.S. Medical Affairs organization, both proactively and in response to inquiries.
• Supports routine and ad hoc audits to monitor and track internal and external compliance with U.S. Medical Affairs processes, as well as governing laws and regulations. Includes implementation of appropriate corrective action plans (CAPs).
• Partners with the HCO and the business to proactively mitigate risks and develop monitoring strategies to monitor and track emerging trends in medical affairs compliance. 
• Generates compliance related metrics and data to drive continuous improvement efforts
• Develops targeted, effective and efficient compliance training for U.S. Medical Affairs.
• Effectively leads and participates on cross-functional initiatives, working groups and project teams.
• Develops and delivers effective communications to promote compliance awareness and policy/process changes within U.S. Medical Affairs.

Other Responsibilities:

• Works with gMAC leadership to contribute to short- and long-term departmental objectives, plans, programs, projects and budgets for quality related efforts.
• Maintains current knowledge and understanding of Genentech products, medical and business strategies, and external factors that could potentially impact gMAC and medical affairs practices.
• Provides guidance and coaching to gMAC team members.

Qualifications and Experience Required:

• Bachelor’s Degree required in Life Sciences or other relevant technical disciplines
• Advanced degree in life sciences or other relevant technical disciplines strongly preferred
• 5-7+ years of multi-disciplinary experience in the biotechnology / pharmaceutical industry
• 3-5+ of experience in working with healthcare compliance principles, guidelines, and regulations
• Previous work-experience gained at Genentech, preferably in Medical Affairs or another compliance-related function, is strongly preferred

E5 Experience Required:

• Demonstrated previous experience with cross-functional problem-solving and driving change through to successful implementation
• Demonstrated experience with prioritizing and management of high level initiatives and projects
• Demonstrated ability to influence and lead both with and without authority; leading innovation and change; and excellent problem solving and decision-making skills
• Must demonstrate knowledge of, or strong aptitude to learn, the legal and regulatory environment as it relates to the pharmaceutical/biotech industry

E5A Experience Required:

• Demonstrated experience in building and leading teams; coaching and developing others
• Demonstrated experience in strategic planning
• Effectively and constructively challenges the status quo, identifying better ways to streamline processes and enable business excellence
• Exhibits professional maturity, confidence, and competence when leading Global and Local projects with high visibility
• Strong conflict resolution and negotiation skills; proven ability to effectively and quickly achieve positive outcomes

Abilities:

• Understands and navigates through organizational dynamics, particularly as they relate to quality and compliance
• Understands life sciences regulatory and compliance landscapes
• Impeccable work ethic and commitment to integrity and quality
• Excellent problem solving and decision making skills
• Ability to work independently and with minimal supervision

Job Summary:

Responsible for working in partnership with the global medical and scientific affairs departments and global business areas to develop and support the medical and scientific vision and strategies.  Provides strategic direction on medical differentiation of products during product development, designs and supports clinical trials to generate medical evidence, publishes results of clinical trials and promotes and leads the exchange of medical and scientific information about disease diagnosis and disease management.  Serves as spokesperson on medical, scientific and clinical matters to internal and external constituents.

Provides strategic decision making, leadership and planning including the efficient and effective use of resources.  Achieves results through the leadership of managerial, professional and/or support staff. Delegates responsibilities to subordinate staff.  Sets policy and strategy for own department. Has full HR responsibility for direct and indirect reports. Has full budget responsibility for assigned functional area or departments.

Responsible for maintaining and continuously improving the quality system and achieving quality objectives through daily actions.

What You Do:

• Oversee the direction, planning and interpretation of clinical trials/research and data collection activities. Establish and approve scientific methods for design and implementation of clinical protocols, data collection systems and final reports.  Develop, plan and interpret clinical trials.
• Direct diagnostic development focus to disease management; capture additional economic value for new diagnostics through outcomes-based studies that demonstrate improved patient benefits and cost effectiveness.
• Work with the Research and Development department in determining clinical feasibility of new products.  Contribute to medical differentiation and risk analysis.
• Serve as global liaison.  Work with the clinical and medical groups within the global organization to identify and implement collaborative studies, regulatory activities and other programs.  Keep abreast of international research in related fields.
• Serve as global liaison.  Work with the clinical and medical groups within the global organization to identify and implement collaborative studies, regulatory activities and other programs.  Keep abreast of international research in related fields.
• Responsible for project training (clinical study) and preparation of technical and scientific publications.
• Serve as clinical spokesperson in a wide range of venues, both internally and externally, such as professional society forums, customer sites and relevant corporate functions.
• Provide medical and scientific expertise input for product development.  Generate clinically robust and ethical outcomes studies.  Direct pre- and post marketing clinical trials by providing expert input in the design, execution and evaluation of trials that support the efficacy of medical devices.  Complete health hazard evaluations to determine potential patient impact.  Coordinate the use of outside medical opinions and ensure collaboration of internal medical and scientific resources.
• Provide input to new business and market development activities in North America, including new business ideation and touch-points with North American market development.  Shape product development and drive the establishment of new standards of care.  Increase sales force disease management knowledge and understanding to enable appropriate clinical adoption of new technologies.  Increase credibility and clinical voice through physician relationships.

Who You Are:

• Doctoral degree in medicine, dentistry or veterinary medicine with 2 years clinical experience or (PhD) Chemistry, Molecular Biology, Microbiology or other scientific discipline with strong clinical expertise
• 8+ years experience in FDA regulated industry with thorough knowledge of product development and clinical studies to support regulatory submissions or generate medical evidence / outcome data
• Experience in dealing with clinicians, senior business leaders and regulatory authorities

Preferred:

• Medical Doctor preferred with strong clinical skills
• 5+ years’ experience in the IVD field with thorough knowledge of clinical studies
• Scientist (PhD) with strong clinical expertise
• Proven leadership and managerial skills
• Extensive cardiac background and knowledge

#LI-ND1

The  Regulatory Advisor in Technical Regulatory Biologics Marketed Products is an individual contributor position that will be responsible for providing senior strategic review and input to product regulatory plans on our broad biologics portfolio, leading and/or engaging in the development of appropriate internal regulatory positions or standards for key topics of products lifecycle management and supporting the broader Technical Operations and Quality organizations in appropriate risk-based decision-making regarding prioritization and trade-offs of various CMC activities and representing PTR on cross-functional projects, governance or leadership teams. Provides oversight and guidance to assigned projects of high importance. The incumbent will also be responsible for coaching/mentoring our technical regulatory staff to strengthen the internal capability of our regulatory professionals and to drive excellence in the regulatory positioning of our lifecycle management strategies. This will also include supporting the overall Roche/Genentech efforts for strong health authority relationships in the areas of CMC through effective communications, interactions and participation in external forums and committees. This position requires deep technical/CMC regulatory expertise with an emphasis in biologics with strong leadership, strategic agility, collaboration, and influencing skills.

MAJOR RESPONSIBILITIES

• Responsible for providing senior strategic regulatory review on strategies, risk management of and complex submissions of the biologic marketed products portfolio of Roche/Genentech for lifecycle management.  Convey opinions to regulatory professionals, project teams, internal governance, and for Pharma Technical and Drug Development initiatives.
• Contribute to internal operations portfolio projects both within PTR, within PT and for the enterprise as required.  Actively represent PTR on cross-functional projects and PTR/PT governance by proactively engaging with stakeholders in developing strategies to address operational efficiencies or operational improvements. May provide oversight and guidance to projects of high importance.
• Provide oversight and guidance to assigned projects of high importance. 
• Contribute to external engagement and interact directly with Health Authorities on product specific and/or policy issues as determined by scope of projects assigned. Actively represents the Roche/Genentech portfolio externally, engages in maintaining effective and timely internal knowledge management on the regulatory landscape and updates the company regulatory strategies accordingly.
• As member of the leadership team, work collaboratively and strategically to establish priorities and directions for the organization, with a focus on enhancing capabilities and driving changes required to realize the department vision. Contributes to the development of department business initiatives and facilitates their implementation.
• Actively engaged in coaching and mentoring the regulatory professionals on regulatory strategy and risk management with an end-to-end and global mindset.
• Fosters a culture of high performance, trust and collaboration. Builds and cultivates a strong network and strengthens partnerships to facilitate knowledge exchange and the sharing of best practices and lessons learned. Interacts closely with key partners and stakeholders from technical, clinical and commercial functions within Roche/Genentech.

QUALIFICATIONS

• Advanced degree in regulatory science, biochemistry, microbiology pharmaceutics, engineering or related field.
• 15+ years experience in regulatory affairs, technical development and drug development, and inclusive of people management experience.
• Extensive global regulatory knowledge on biologics development and marketed products, including laws, regulations and directives. Proven track-record as a regulatory expert on assessing regulatory submissions and in dealing with CMC regulatory questions and issues, including defining innovative strategies and partnering with Health Authorities.
• Highly collaborative with demonstrated ability to build a strong network and manage stakeholder and senior management relationships, both internally and externally.
• Proven track record of cross-functional leadership, including leading teams through different stages of product development and life-cycle management, advising others on strategic context and interconnectivities.
• Broad technical expertise and interest in continuous learning in biologics drug development and in developing others.
• Highly agile and action-oriented.
• Fluent in English. If applicable, additional language spoken in region of responsibility is desired. (I removed this from other job description as US based)
• Excellent verbal and written communication skills with success in influencing others in cross-functional and multidisciplinary settings. Strong negotiation skills.
• Proven ability to work proactively and think strategically
• Ability to travel according to the needs of the role and can be up to 25%  

The Regulatory Advisor/Chief-of-Staff in Technical Regulatory Biologics Marketed Products is an individual contributor position that will be responsible for providing senior strategic review and input to product regulatory plans on our broad biologics portfolio, leading and/or engaging in the development of appropriate internal regulatory positions or standards for key topics of products lifecycle management and supporting the broader Technical Operations and Quality organizations in appropriate risk-based decision-making regarding prioritization and trade-offs of various CMC activities and representing PTR on cross-functional projects, governance or leadership teams.  The individual will also be responsible for coaching/mentoring our technical regulatory staff to strengthen the internal capability of our regulatory professionals and to drive excellence in the regulatory positioning of our lifecycle management strategies. This will also include supporting the overall Roche/Genentech efforts for strong health authority relationships in the areas of CMC through effective communications, interactions and participation in external forums and committees. This position requires deep technical/CMC regulatory expertise with an emphasis in biologics with strong leadership, strategic agility, collaboration, and influencing skills. May provide oversight and guidance to projects of high importance.

The position will also support the Biologics Marketed organization as the Chief of Staff.  In this capacity, the incumbent supports administrative, financial, and operational activities for the organization including managing Biologics Marketed operational racetrack and LT meetings.  Organizes and prioritizes critical issues and required information for the leadership team to facilitate efficient decision making.

MAJOR RESPONSIBILITIES

• Responsible for providing senior strategic regulatory review on strategies, risk management of and complex submissions of the biologic marketed products portfolio of Roche/Genentech for lifecycle management.  Convey opinions to regulatory professionals, project teams, internal governance, and for Pharma Technical and Drug Development initiatives.
• Contribute to internal operations portfolio projects both within PTR, within PT and for the enterprise as required.  Actively represent PTR on cross-functional projects and PTR/PT governance by proactively engaging with stakeholders in developing strategies to address operational efficiencies or operational improvements. May provide oversight and guidance to projects of high importance.
• Contribute to external engagement and interact directly with Health Authorities on product specific and policy issues. Actively represents the Roche/Genentech portfolio externally, engages in maintaining effective and timely internal knowledge management on the regulatory landscape and updates the company regulatory strategies accordingly.
• Actively engaged in coaching and mentoring the regulatory professionals on regulatory strategy and risk management with an end-to-end and global mindset.
• Provide management support for the LT inclusive of organization management (meetings and communication) and financial/budget management
• Organizes and prioritizes critical issues and required information for the leadership team to facilitate strategic decisions.
• Establish LT meeting cadence and manage LT agendas, track and monitor LT decisions and actions; hold LT members accountable to decisions and actions.
• As member of the leadership team, work collaboratively and strategically to establish priorities and directions for the organization, with a focus on enhancing capabilities and driving changes required to realize the department vision. Contributes to the development of department business initiatives and facilitates their implementation.
• Fosters a culture of high performance, trust and collaboration. Builds and cultivates a strong network and strengthens partnerships to facilitate knowledge exchange and the sharing of best practices and lessons learned. Interacts closely with key partners and stakeholders from technical, clinical and commercial functions within Roche/Genentech.

QUALIFICATIONS

• Advanced degree in regulatory science, biochemistry, microbiology pharmaceutics, engineering or related field. Master’s degree in Business Administration (MBA) is desired.
• 15+ years experience in regulatory affairs, technical development and drug development, and inclusive of people management experience.
• Extensive global regulatory knowledge on biologics development and marketed products, including laws, regulations and directives. Proven track-record as a regulatory expert on assessing regulatory submissions and in dealing with CMC regulatory questions and issues, including defining innovative strategies and partnering with Health Authorities.
• Highly collaborative with demonstrated ability to build a strong network and manage stakeholder and senior management relationships, both internally and externally.
• Proven track record of cross-functional leadership, including leading teams through different stages of product development and life-cycle management, advising others on strategic context and interconnectivities.
• Broad technical expertise and interest in continuous learning in biologics drug development and lifecycle management and in developing others.
• Highly agile and action-oriented.
• Excellent verbal and written communication skills with success in influencing others in cross-functional and multidisciplinary settings. Strong negotiation skills.
• Proven ability to work proactively and think strategically
• Ability to travel according to the needs of the role and can be up to 25%  

Genentech is seeking locally based applicants for project management opportunities based in South San Francisco.  

Considering local candidates only.

Sr. Project Manager / Principal Project Manager is responsible for managing projects to successful and timely decision points from Late Stage Research through Proof of Concept. This role contributes to the definition of project strategy and guides the project core and sub teams to deliver on project objectives. Additional responsibilities include the following:

• Establish and maintain functionally integrated project schedules to enable accurate project, financial and portfolio analyses and ensure accurate inputs are provided into business planning processes. Ensure alignment with project sub-teams and functional partners.
• Oversee and prepare project team budget including resources and costs, collaborating with Finance and other cross-functional departments.
• Communicate, document and archive project team activities and decisions. Act as a primary contact for project team related information.
• Facilitate project team meetings, cross-functional communication and decision making, ensuring alignment with internal and external stakeholders.
• Identify, recommend and implement opportunities for streamlining team and business processes.
• Ensure the team achieves and maintains a high-level of sustainable performance by contributing to appropriate team management best practices.

Successful candidates will meet the following minimum requirements. The level of the position will be based on the qualifications of the selected candidate:

• Minimum 6-8 years of multi-disciplinary experience in the biotech/pharmaceutical industry.
• Minimum 2 years direct project management experience in drug development with knowledge of the overall drug development process.
• Experience using Project Management software to manage complex project timelines and resources.
• Bachelor's degree in the Life Sciences. Advanced degree is desired.
• PMP (Project Management Professional) certification is a plus.

At a minimum, strong candidates will demonstrate the following:

• Strong proficiency with project management practices, tools and methodology.
• Financial acumen with capability to plan and oversee project budgets and product valuations
• Understanding of portfolio management concepts.
• Excellent interpersonal skills with the ability to develop important relationships with customers and key stakeholders.
• Good conflict management skills.
• Excellent analytical skills.
• Strong communication and presentation skills with the ability to communicate complex information effectively.
• Ability to translate strategy into action.
• Strong influencing and negotiation skills.
• Proven track record of good decision making and exercising sound judgment.
• Embraces working in a culture where receiving and providing feedback is valued.
• Results and detail-oriented.
• Self-motivated.

#LI-GREDKM2

Considering local candidates only.

Genentech is seeking locally based applicants for project management opportunities based in South San Francisco.  

The Project Manager is responsible for managing projects to successful and timely decision points from Late Stage Research through Proof of Concept. This role contributes to the definition of project strategy and guides the project core and sub teams to deliver on project objectives. Additional responsibilities include the following:

• Establish and maintain functionally integrated project schedules to enable accurate project, financial and portfolio analyses and ensure accurate inputs are provided into business planning processes. Ensure alignment with project sub-teams and functional partners.
• Oversee and prepare project team budget including resources and costs, collaborating with Finance and other cross-functional departments.
• Communicate, document and archive project team activities and decisions. Act as a primary contact for project team related information.
• Facilitate project team meetings, cross-functional communication and decision making, ensuring alignment with internal and external stakeholders.
• Identify, recommend and implement opportunities for streamlining team and business processes.
• Ensure the team achieves and maintains a high-level of sustainable performance by contributing to appropriate team management best practices.

Successful candidates will meet the following minimum requirements:

• Minimum 2 years of multi-disciplinary experience in the biotech/pharmaceutical industry.
• Prior direct project management experience in drug development with knowledge of the overall drug development process.
• Experience using Project Management software to manage complex project timelines and resources.
• Bachelor's degree in the Life Sciences. Advanced degree is desired.

At a minimum, strong candidates will demonstrate the following:

• Strong proficiency with project management practices, tools and methodology.
• Financial acumen with capability to plan and oversee project budgets and product valuations
• Understanding of portfolio management concepts.
• Excellent interpersonal skills with the ability to develop important relationships with customers and key stakeholders.
• Good conflict management skills.
• Excellent analytical skills.
• Strong communication and presentation skills with the ability to communicate complex information effectively.
• Ability to translate strategy into action.
• Strong influencing and negotiation skills.
• Proven track record of good decision making and exercising sound judgment.
• Embraces working in a culture where receiving and providing feedback is valued.
• Results and detail-oriented.
• Self-motivated.

#LI-GREDKM2

We are seeking a highly motivated postdoctoral research fellow to join the Rutz lab in the Department of Cancer Immunology at Genentech. The successful candidate will initiate an independent research project to investigate mechanisms that regulate T cell responses and immunosuppression. The expectation is that this work will result in novel and important contributions to our understanding of the regulation of adaptive immune responses and immunosuppression in cancer and chronic inflammation resulting in publications in top tier scientific journals. 

The Rutz lab collaborates with several investigators at Genentech and beyond, applying cellular immunology, gene-editing, single cell sequencing, proteomics, and mouse models to study T cell biology during chronic inflammation and cancer. Currently, the lab is focused on regulatory T cell function in cancer, as well as approaches to elicit and potentiate CD8 T cell anti-tumor responses.

Requirements: Ph.D. in Immunology, Biochemistry, Molecular Biology or a related field. The successful candidate will have strong work ethics, a steadfast commitment to discovery research and a documented ability to initiate, drive and complete research projects, as evidenced by a strong publication record. A background in T cell immunology, molecular biology and signaling, experience with mouse models and a motivation to harness new/emerging technologies are desirable. We are looking for a candidate with excellent communication and organization skills. 

For more information about the Genentech postdoctoral program, please visit:

https://www.gene.com/careers/university-and-early-career/postdocs

 

Target Start Date: March 2019, and June/July 2019

Length of Internship: 1 year

Work hours: 40 hours per week

Product Development Regulatory (PDR) is responsible for the timely submission of applications to health authorities for approval of new products and line extensions. PDR is committed to regulatory strategies that are the most innovative, ethical, and influential in the industry. This intern position is in the Regulatory Affairs department, involving global product development and post-marketing programs, working with key partners in development. Additional activities involve global and US labeling, and US promotion and advertising, working with key partners in production, quality, marketing, legal, and development. The successful candidate will participate directly with one or more of our current teams. This is an opportunity to explore using your science background in a business environment. The internships are 6-12 months duration with possibility for extension.

Qualifications

• Recent graduate from degree program (BS, MS, PhD, PharmD)
• Degree in life sciences, business, or engineering

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The mission of Translational Oncology is to discover new targets and identify and characterize first- and best-in-class clinical candidates. We help guide clinical development of these drugs through a deep understanding of their unique mechanisms of action, define patient populations that are most likely to respond and biomarkers predictive of this response.

Project 1: (Bachelor or Master)

The intern will focus on developing assays to assess immune cell function.  The intern will be helping to develop in vitro and ex vivo assays to assess immune cells from tumor preclinical models and human samples.  The intern will focus on standardizing various immune cell intracellular signaling markers and utilizing these in cell-based immunological assays.

Applicants should be currently pursuing an undergraduate or graduate program within the fields of Cancer Biology, Cell Biology, Immunology or Molecular Biology.  The ideal candidate will have demonstrated prior wet lab experience in a Cellular Biology, Molecular Biology or Immunology lab. 

The candidate must have experience in tissue processing, hands-on experience in tissue culturing, experience in flow cytometry, and comfort working with animal or human tissue samples. Candidate must also be proficient in PowerPoint or Google Slides presentations and have the ability to present data to the scientific community.

Project 2: (Master or PhD)

The intern will be involved in developing novel in vitro immune cell-based assays for the evaluation of antibody mediated ADCP, phenotypic changes on target cells and cytokine secretion as well as generating and differentiating T cell and dendritic cells for in vivo transfer into tumor bearing mice. Additional responsibilities will include murine tissue processing and FACS analysis.

Specific Responsibilities include:

• Generation of bone marrow derived macrophages and dendritic cells.
• Co-culture and ADCP assays with target tumor cells.
• Culturing of murine tumor cell lines.
• Flow cytometry characterization of immune cell subsets.
• Tissue processing from murine tumor studies.
• FACS analysis of tumor immune infiltrates.

Applicants should be currently pursuing a PhD or MS degree and have research expertise in immunology, oncology, biology or related field. Technical experience with tissue culturing techniques, tissue processing, FACS analysis and in vitro immune cell differentiation is desired. Candidate will be expected to perform data acquisition and analysis and work with other scientists to evaluate and present findings. Excellent teamwork, enthusiasm, collaboration and communication skills are essential. Experience with FACS analysis is a must.

Project 3: (BS, Master, or PhD)

The intern will help implement cell-based assays to test the effects of PI3K inhibitors for oncology. The goal of the work is to characterize the mechanism of action of the compounds, as well as to aid in the development of appropriate diagnostic assays. Intern will be expected to perform data acquisition and analysis and work with other scientists in our group to evaluate and present findings.

Applicants should be currently pursuing a BS, MS, or PhD in a biological discipline with background in molecular and cell biology, biochemistry, and/or experience working with cell culture and standard molecular biology techniques. Experience with tumor cell culture, western blotting and signal transduction pathways is a plus, as is experience. Candidate will be expected to perform data acquisition and analysis and work with other scientists in our group to evaluate and present findings.

Project 4: (BS, Master, or PhD)

The intern will evaluate biomarkers for sensitivity of ovarian, endometrial and breast cancer cell lines to DNA damage and G2/M cell cycle checkpoint inhibitors as single agents and in combination with chemotherapy.

 Specific Responsibilities include:

• Evaluate status of replicative stress in sensitive vs. resistant lines
• Evaluate the functionality of DNA damage repair checkpoints in response to S phase DNA damage at baseline and in combination with DNA damage checkpoint inhibitors and
• Evaluate presence of mitotic catastrophe as mechanism of cell death.

The intern will also evaluate the effects of Rb loss on replicative stress and response to CDK inhibition

Applicants should be currently pursuing a BS, MS, or PhD in Cell & Molecular Biology or Pre-Med. Experience with flow cytometry, microscopy, tissue culture, and Western blotting.

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The Discovery Chemistry mission is to design and synthesize safe and effective medicines for treating significant unmet medical needs by applying state-of-the-art structure-driven and property-based design principles in a multi-disciplinary, team-based culture.

Responsibilities

Intern will utilize a combination of analytical chemistry and deep learning to develop a high-throughput solubility assay for small molecules. Intern will be responsible for acquiring images using polarized light microscopy and using LCMS/CAD to quantify concentrations in samples. Additionally, convolutional neural network will be utilized to classify state of crystallization.

Qualifications

Bachelor of Science (Sophomore Level or Higher, or Recent Grad), Master of Science (1st or 2nd Year or recent grad), PhD Student (pursuing PhD, not completed)

Preferred majors in analytical chemistry, computer science, programming

Start Date: Summer 2019

Length of Assignment: 9-12 weeks

Work Hours: 40 hours per week

The Genentech Chemistry Internship Program is an intensive 3-4 month opportunity where undergraduate chemistry students work within the fast-paced and challenging environment of our South San Francisco, CA research headquarters. Undergraduate chemistry Interns contribute to synthetic chemistry projects, interacting with and working side-by-side with drug discovery industry experts. Specific projects designed by our scientists will provide the interns with hands-on synthetic chemistry experience, such as designing and synthesizing novel compounds for chemistry exploration and developing new reaction methodology. Interns will gain valuable experience using the latest laboratory equipment and tools in a world-class research environment.

 

Applicants must be in the process of earning or recently earned a BS in Chemistry and have completed at least 2 years of college undergraduate education by summer 2019. Additionally, the applicants should display an excellent academic record (minimum 3.0/4.0 GPA) and be a full-time student.  Prior chemistry laboratory experience in the academic setting or biotechnology/pharmaceutical industries is required.  Applicants should also convey strong quantitative and analytical skills, demonstrated ability and experience in effectively interacting with teams, and excellent written and verbal communication skills. 

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The Small Molecule Pharmaceutical Sciences (SMPS) mission is to develop a world-class CMC organization recognized for high quality science, innovative approaches, and ability to rapidly respond to changes in clinical development. To expeditiously develop and deliver phase appropriate formulations, chemical synthesis, process characterizations and controls to enable a robust dynamic and diverse pipeline using innovation high quality science, technologies and partnerships.

Project 1 (Senior-year BS student or Recent graduate)

The intern candidate will participate in a 12-week research project to investigate the flow properties of pharmaceutical powders. The research responsibilities include but are not limited to:

• Conducting powder flow characterization of pharmaceutical powders using multiple techniques, such as ring shear cell tester, and flow-through-orifice device.
• Performing bench-scale unit operations such as powder blending and lubrication, powder discharging, and laboratory-scale tablet compression.
• Performing data analysis following engineering principles.
• Communicating results and conclusions, both internally and externally, by poster/podium presentation and publication on a peer-reviewed journal.

Qualifications

• Degree in mechanical Engineering, Materials Science, Chemical Engineering or Pharmaceutics
• A GPA of 3.0 or above
• Proven understanding and interests in mechanics and materials science, especially relevant to granular solids
• Demonstrated problem-solving skills and strong communication skills are required
• Knowledge and experience in bulk powder characterization techniques are a plus
• Knowledge and experience in solid dosage formulation development are a plus

Project 2 (Bachelor or Master)

The intern candidate's primary responsibility will be developing and executing a study to identify areas of improvement in the Building 47 GMP Manufacturing Operations. The intern candidate will track and identify downtime in processes, map process flows, and tabulate / present data to engineering team. The goal of the project is to determine the operating efficiency of the area, identify failure points, and recommend improvements to increase operating efficiency.

The intern candidate will work with Senior Engineer on qualification protocols and facility management or continuous improvement initiatives as a developmental assignment. The intern candidate will learn the qualification process for equipment in a GMP pharmaceutical manufacturing environment and assist in execution of protocols if internship timelines / business timelines coincide.

The intern candidate will perform document reviews and assessments of procedure "fit-for-purpose" status following training periods and gaining an understanding of the operational processes of the GMP Manufacturing Area.

The intern candidate will observe and participate in R&D manufacturing operations as appropriate to develop understanding of small molecule solid oral dose manufacturing and as appropriate to understand the operation for the primary efficiency study goal.

Qualifications

• Degree in Operations Engineering, Industrial Engineering, or Chemical Engineering
• Looking for continuous improvement competency, creation of experiments and metric designs
• University-level statistics highly desired

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The Small Molecule Pharmaceutical Sciences mission is to develop a world-class CMC organization recognized for high quality science, innovative approaches, and ability to rapidly respond to changes in clinical development. To expeditiously develop and deliver phase appropriate formulations, chemical synthesis, process characterizations and controls to enable a robust dynamic and diverse pipeline using innovation high quality science, technologies and partnerships.

Project 1 (Master, PhD, or PharmD)

We are seeking an intern who is driven to study the innovative approach for novel drug delivery. This individual will design the formulation for target drug delivery and utilize physical and chemical characterization to understand the formulation compositions.

Qualifications

• Master of Science (1st or 2nd Year or recent grad), PhD Student (pursuing PhD, not completed), PharmD
• Degree in Chemistry, Bioengineering, Material Science Engineering, or Pharmaceutical Science
• HPLC and solid-state characterization.
• Skilled in nanoparticle formulation and characterization

Project 2 (Bachelor, Master, PhD, or Pharm D)

This project would establish guidelines to help rapidly select the most appropriate excipients and formulations for the early phase evaluation of suitable APIs and provide time-saving ready-to-use strategies in the emulsion platform. The intern would work on a number of different model compounds with diverse properties to generate kind of “formulation Structure property relationship,” in lipid formulations and performing a complete emulsion formulation screen.

The steps involved would be:

• API solubility screening in co-solvents, water soluble surfactants, water-dispersible surfactants, oils and water-insoluble surfactant
• Excipient selection based on API solubility and type of lipid formulation suitable for API
• Determining solubility of API in mixture of excipient (limit to maximum three)
• Generating phase diagram on these excipients and selection of prototype formulation
• Full characterization of the prototype formulation using in-vitro dispersion test, lipolysis and other standard characterization After full characterization, the emulsion formulation may be compared with the established formulation in-vivo to establish performance.

Qualifications

• Bachelor of Science (Sophomore Level or Higher, or Recent Grad), Master of Science (1st or 2nd Year or recent grad), PhD Student (pursuing PhD, not completed), PharmD
• Degree in Pharmaceutical Chemistry, Physical Chemistry, Bioengineering, or Biotechnology
• Formulation and pre-clinical formulation skills are desirable

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The mission of the Immunology department is to expand the fundamental understanding of human immune disorders by discovering and developing innovative drugs for the treatment of immune and inflammatory disorders.

Hyper-inflammatory diseases, including allergies and asthma, are caused by an uncontrolled immune system that responds to otherwise innocuous stimuli. Pathogenic T helper (Th) cells play a central role in the establishment and progression of allergic diseases, and therapies that aim to cure asthma focus on manipulating or suppressing patient’s T helper cells.

Non-coding RNAs, including microRNAs, play a key role in the regulation of T cell activation and effector function, as they control specific cellular pathways at the post-transcriptional RNA level.

Our lab is interested in better understanding the role and therapeutic potential of microRNAs in pathogenic T helper cells, to cure asthma.

The manipulation of genes using CRISPR-CAS9 has substantially expanded the biologist’s toolkit, and holds promise to revolutionize medicine. However, CRISPR is primarily used for the depletion, rather than the modification, of genes of interest. We want to develop a new CRISPR system to manipulate, but not knockout, small-RNA encoding genes in T cells, as we believe this new tool would transform our understanding of biology, to the benefit of patients.

We are looking for an enthusiastic and committed intern who will contribute to the development of a novel CRISPR system that introduces single nucleotide mutations (SNMs) in small RNA genes. The candidate will design CAS9 guide-RNAs for a novel CAS9 protein, and use different transfection protocols to study gene regulation. The candidate will use Next Generation Sequencing (NGS) to validate SNMs, and will study the impact that a single point mutation has on the miRNA stability, function and effect on T helper cell function.

Qualifications

• PhD Student (pursuing PhD, not completed), PharmD
• Degree in Immunology and/or Molecular Biology

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The mission of the Immunology department is to expand the fundamental understanding of human immune disorders by discovering and developing innovative drugs for the treatment of immune and inflammatory disorders.

Project 1

Our focus is to study the role of cell types, molecules and pathways in immune mediated diseases as well as normal immune responses. The successful candidate will utilize in vitro and in vivo models of human and mouse immune diseases and immune responses.

Qualifications

• At least in 3rd or 4th year of BS degree, Master of Science (1st or 2nd Year or recent grad), PhD Student (pursuing PhD, not completed), or PharmD
• Degree in Biology, Immunology, Biochemistry, or Biotechnology
• Strong performance in relevant academic courses in (e.g., Immunology, Biology, Biochemistry, Genetics, etc.) is required
• Previous laboratory experience (e.g., summer positions, publications) will be preferred
• Self-motivation, teamwork, and dedication to quality in a fast paced scientific setting

Project 2

Previous work in the Jasper Lab has established the regulation of cytosolic calcium oscillations as critical for the control of Drosophila Intestinal Stem Cell (ISC) activity (Deng et al, Nature 2015). Similar mechanisms may also act as conserved regulators of mammalian ISC activity, as unpublished data from the Jasper Lab has revealed cytosolic calcium oscillations within a subpopulation of mouse intestinal crypt cells.

The intern project will expand upon these preliminary observations in lineage-traced intestinal organoids by

• using immunostaining to identify whether the oscillating cells are ISCs
• using pharmacological perturbations to test whether calcium oscillations are required for ISC function and differentiation
• use genetic perturbations to identify potential signaling pathways regulating calcium oscillations in ISCs.

Qualifications

• Master of Science (1st or 2nd Year or recent grad), PhD Student (pursuing PhD, not completed)
• Degrees in Biology, Regenerative Medicine, Genetics, or Stem Cell Biology
• Organoids, Live Imaging, Signal Transduction, CRISPR, Microscopy, Cell Culture, Molecular Biology

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The gRED Biomarker Discovery OMNI Group seeks to understand disease heterogeneity and discover biomarkers that define patient subsets, are prognostic for disease activity or predict progression towards more severe disease.

We are seeking a motivated and intellectually curious intern to perform research related to biomarker discovery and analysis in inflammatory disease with a focus on inflammatory bowel disease. The successful intern candidate will use cell culturing and classical microbiology techniques to evaluate host cell response to microbial metabolites. The intern candidate will be expected to perform data acquisition and analysis independently and interact with various researchers to better evaluate and interpret findings. Responsibilities will include mammalian cell culturing, microbial isolation/culturing, and QPCR protocol development.

The ideal applicant will be a currently enrolled undergraduate or graduate student with demonstrated interest in immunology, microbiology, or a related field and previous experience with bacterial and mammalian cell cultures. Good communication, problem-solving, and critical thinking skills along with strong self-motivation and the ability to integrate findings into a larger disease-oriented context will be expected. Computational experience (R, Python, etc.) is a plus.

Start Date: Summer 2019

Length of Assignment: 12 weeks

Work Hours: 40 hours per week

The Bioinformatics and Computational Biology mission is to provide the information systems including the methods, software, databases, infrastructure, and training required for Research to access and analyze DNA and protein sequence information and related biological data. To utilize these information systems to analyze biological information and to identify genes of therapeutic interest.

Project 1

This project will leverage the extensive data collected at Genentech for the PI3K and MEK inhibitor programs (eight clinical-grade molecules tested in up to ten different tumor models at multiple concentrations) to build computational models predictive of ?in vivo? tumor response based on physico-chemical properties of the molecules and ?in vitro? potency/efficacy data.

Specific tasks and responsibilities:

• Model and predict drug efficacy using in vitro and in vivo data
• Develop Pharmacokinetics & pharmacodynamics models for targeted therapies
• Collect and align in vitro and in vivo data from multiple projects
• Develop and benchmark different modeling approaches

Qualifications

• Pursuing PhD (preferably in Systems Biology, Computational Biology, Bioengineering or Biophysics)
• Programming (R, python, or MATLAB)
• Mathematical modeling (ODE, parameter fitting, and machine learning)
• Pharmacokinetics & pharmacodynamics (PKPD)

Project 2

Intra-tumoral heterogeneity represent a significant barrier in achieving durable therapeutic responses in the clinical setting. Among other mechanisms, the dynamic change in cellular transcription profiles has been shown to drive drug resistance to several FDA-approved therapies. Here we aim to leverage scRNA-Seq to gain insight into the transcriptional changes associated with drug tolerance and sensitivity. This position will be assisting in analyzing RNA-Seq and scRNA-Seq data using best-practices methods to gain biological insights into factors that drive treatment resistance.

Qualifications

• Pursuing PhD in bioinformatics, biostatistics / statistics, computational biology, systems biology, computer science, or related field
• Familiarity with Linux working environment and high-performance computing recommended
• Proficiency in R or Python is greatly preferred, skills with other high-level programming languages and experience in standard bioinformatics toolkits and programs highly desired
• Applicants with experience analyzing RNA-Seq data preferred but not required

Project 3

Shiny R developer to create R based web-app prototype for high-throughput analysis of Tn-seq data Tn-seq is a high throughput technique for analysis of transposon mutant libraries. Seeking an intern passionate about applying your programming experience to utilize bioinformatics methods to help understand the biology of infectious diseases. The intern candidate, experienced in R Shiny, will build an R based web app for analysis of Tn-seq data. The app will be used to quantify the contribution of individual genes and operons to bacterial fitness in infectious settings, and during selection with antibiotics.

Tasks and responsibilities include: Read trimming, barcode splitting and mapping Implementation of fitness calculations and statistics Genome-wide visualization of transposon insertions

Qualifications

• Pursuing a PhD in Bioinformatics, Computational Biology, Computer Science, or a related field
• Proficient in a least one scripting language; preferably R
• Experience developing interactive web-based applications using R Shiny
• Experience working with large-scale genomic data; preferably Tn-seq

Start date: Summer 2019

Length: 10-12 weeks

Design, Engineering, and Construction Services (DECS) is a group within Design & Construction (D&C). The DECS Group is comprised of SMEs (Subject Matter Experts) in the following disciplines: Architecture, Mechanical, Electrical, Automation, Environmental Health & Safety, and Construction Services, which includes Badging & Training, Project Coordination and Closeout. Responsibilities by the DECS Group includes providing subject matter expertise in respective disciplines to D&C Project Managers who execute ~180 construction projects annually for customers within SSF campus.

Start date: Summer 2019

Length: 6 months

The mission of Hospitality is to deliver value-added operations, programs, and services that are laser-focused on enhancing the daily experience of our workforce, visitors, and guests. These essential functions touch our 12,000+ employees, contractors, consultants, partners, and visitors on a daily basis.