We are looking for a talented Hematologist  / Oncologist to join our Rare Blood Blood Disease team as a Medical Director (Senior Medical Director).

Roche’s Clinical Development organization is structured by therapeutic area and is responsible for developing and executing the late development (Phase II – IIIA) clinical strategies and plans that deliver medically-differentiated therapies that provide meaningful improvement to patients. The PD Medical Director participates in development of the Clinical Development (CD) strategy and is responsible for developing the CD plan and ensuring effective and efficient CD plan execution for the assigned molecule(s)/indication(s). PD Medical Directors may have one or more direct reports. PD Medical Directors are expected to perform their responsibilities with more independence by comparison to Associate PD Medical Directors, including participating in health authority (HA) interactions with little to no supervision from their managers.

1. Cross-Functional Team Membership

• Participates in the relevant Clinical Science Team (CST)

• Participates as a standing or ad hoc member in sub-teams (e.g., Study Management Teams) relevant to assigned molecule(s)/indication(s) and supports the CST lead and overall team with cross-functional integration, coordination and alignment to enable effective and efficient CD plan execution

• As requested, supports the CST lead and overall team with training new CST members

• May also, as appropriate, support relevant sub-teams in training new team members

2. Global Clinical Development Planning

• Stays abreast of internal and external developments, trends and other dynamics relevant to the work of CD to maintain, at all times, a fully current view and perspective of internal/external influences and/or implications for the assigned therapeutic and disease area(s)

• Maintains the highest standards and levels of scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment

• Collaborates with a variety of internal and external partners and stakeholders, such as clinical investigators, clinicians, scientists and key opinion leaders (KOLs), as well as multidisciplinary internal groups, including other groups in PD, research, regulatory, business development, commercial operations, legal, etc.

• Supports other CST members with development of clinical science information for inclusion into annual and strategic Lifecycle Plans (LCPs) and the Integrated Development Commercialization Plan (IDCP)

• Supports internal partners in transitioning new drugs/indications into Phase IIIB or publication studies. May review Phase IIIB protocols and other information and provide CD input

• Participates in development of the CD plan for assigned molecule(s)/indication(s) and/or other programs:

• Supports other CST members in preparing for HA meetings. As appropriate, participates in HA meetings. Ethically, effectively and professionally represents the interests of Roche and patients

3. Clinical Development Plan Implementation

• Provides clinical support across all relevant studies and programs

• Participates in ongoing CST and relevant sub-team meetings, Development Working Group (DWG), other interactions and communications

• Designs and develops clinical studies for review and discussion with other CST members

• Collaborates with others in development of clinical sections of investigator brochures, presentations and other materials

• Participates in investigator and other external presentations, meetings and other communications

• Acts as a medical monitor for assigned studies

• Conducts ongoing reviews of medical/safety data

• Collaborates with relevant teams and other groups to measure and monitor study progress against objectives and plans, including any variances, and proactively communicate any issues, challenges and potential strategies to resolve such

• Reviews study data to ensure correct medical/scientific data interpretation for interim and final study reporting

• Participates in the development and implementation of communications strategies to support existing and concluded studies. Includes KOL interactions, advisory boards, major medical meetings, congresses and other events, publications and other materials

• Works with other CST members, regulatory and other internal partners/stakeholders in the completion and submission of regulatory filings and other regulatory documentation. Supports others with clinical science

• Consistently complies with all governing laws, regulations, Roche Standard Operating Procedures (SOPs) and other guidelines

QUALIFICATIONS & EXPERIENCE

We are looking for a professional M.D. with relevant medical training in hematology / oncology required (M.D/PhD a plus) and 2 or more years (6 or more years for senior MD) pharma/biotech industry experience OR is a recognized expert in the field. You will bring:

• 2 or more years (6 or more years for senior MD) experience with clinical trials across Phase II – III drug development

• Academic/teaching background is a plus

• Experience working with the principles and techniques of data analysis, interpretation and clinical relevance (e.g., ISS, ISE, competitor data, etc.)

• Experience developing product and safety profiles

• Experience submitting an NDA/BLA to regulatory authorities in Europe and/or the U.S. is preferred (relevant for Senior MD)

• Versed in medical aspects of GCP (Good Clinical Practice), ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use), FDA, EMEA, NICE and other relevant guidelines and regulations

ABILITIES:

• Has impeccable ethics. Demonstrates, or proven abilities to demonstrate, Roche Values

• Outstanding attention-to-detail

• Has working knowledge of the multi-disciplinary functions involved in a company’s drug development process, e.g. clinical operations, biostatistics, regulatory, commercial operations, etc.

• Good interpersonal, verbal communication and influencing skills; can influence without authority

• Good judgment and decision-making skills; knows how to make trade-off decisions while balancing ethics and efficacy

• Clinical leadership: is regarded as an expert in his/her field, is highly respected by others, can effectively contribute to longer-range drug development, and can lead cross-functional teams to successful results (for senior MD)

• Ability to travel globally (<30%)

Roche is an equal opportunity employer.

In US Medical Affairs (USMA), we focus on broadening opportunities for patient access by ensuring that health care stakeholders have the evidence they need on our products and the confidence in that evidence to make informed treatment decisions. As a key pillar in the broader Genentech organization, USMA has a pivotal role in bridging internal partner functions (including Research, Product Development, Commercial, and Government Affairs) and collaborating across the dynamic health ecosystem to ultimately deliver better patient outcomes while making care more accessible and affordable for all.

Position Overview:

The Senior Therapeutic Area Lead in Medical Information is focused on developing the strategy and implementation plan as well as executing on content creation for multiple channels in a specific therapeutic area to assure scientifically accurate, impactful communications to patients, HCPs, and access stakeholders. Key responsibilities include planning, execution, creation, and review of scientific content for customer engagement, responding to medical and access inquiries, and strategic application of customer insights. You assure that the medical content provided via established and digital Medical Information channels as well as via the medical and commercial field interactions is strategically impactful, timely, accurate, and in a customer-focused format by:

• Planning, developing, and advancing the functional as well as influencing the cross-functional scientific communication strategies in support of the medical priorities of the Medical Network and the Squad in the assigned molecule/product/therapeutic area

• Acting as a Medical Information clinical expert of the assigned molecule/product/therapeutic area to internal and external customers, and as a medical communications expert in crafting medical content that is compliant and resonates with patients, HCPs, and access stakeholders; consistently approaching interactions with clinical integrity and the highest professional ethics in accordance with guidelines, direction, and key strategies

• Anticipating, identifying, articulating, and solving concerns on clinical, access, and operational issues (e.g., PI, PRC/RDC/MRT, pathways, guidelines, systems, processes) that impact Medical Information, Medical Affairs, and customers; and contributing to the development of new principles and concepts in solving these unusually complex problems

• Informing the development of Lifecycle/Medical Plans and medical initiatives to fill customer knowledge gaps through the strategic use of Medical Information/Medical Affairs insights

• Anticipating and applying an expert understanding of the medical information needs of worldwide customers and providing strategic responses to complex medical information requests with a highly developed knowledge of all customer types

• Independently leading departmental, cross-functional, and interdisciplinary team meetings and projects involved with complex issues, and contributing to inter- and intra-departmental business decisions

• Ensuring our partners have an understanding of the issue and the potential business impact of the key trends, themes or other evolutions in the external legal and regulatory landscape that relate to the work of Medical Information in the relevant therapeutic area(s)

• Identifying, influencing, and regularly checking in with external department leaders to understand their needs and perspectives as well as strengthen relationships to effectively move initiatives forward

• Ensuring assigned goals and objectives are met and that assigned work is completed on time, to high standards and within budget; also, providing guidance and managing work activities of others to accomplish goals and objectives

Core Accountabilities:

Depending on the resource model for the assigned therapeutic area, you may perform or oversee the following activities:

 

Strategy/Planning:

• Drive communication and content plans to be strategically aligned with medical priorities, deliver impactful results, and push innovation in cross-functional teams solving for complex issues that impact patients, HCPs, and access stakeholders

• Partner with stakeholders across USMA, Genentech, and Roche to break down silos to achieve results for the medical priorities

• Lead the medical information launch plan and strategy for the assigned molecule(s) or line extension(s) by working collaboratively and efficiently with all internal team members, partners and stakeholders to meet the anticipated and known medical information needs of patients, HCPs, and access stakeholders

• Inform the development of medical plan strategies and tactics through the strategic use of Medical Information/Medical Affairs insights for assigned molecules/products

• Proactively research, analyze and communicate key trends, themes or other evolutions in the external legal, regulatory, and access landscape that relate to the work of Medical Information in the relevant therapeutic area(s); innovate, develop, and contribute to updating and implementing departmental policies, procedures, and guidelines based on this knowledge

• Work with medical science liaisons (MSLs), medical executive directors (MEDs), medical science directors/medical directors (MSDs/MDs), medical partners, and Publication Planning to develop, disseminate and manage the timelines for scientific content communications and other relevant research and data communications for assigned molecules/products

• Maintain an in-depth understanding of relevant medical strategy and clinical, patient/caregiver, payer, and healthcare/market landscape

Medical Writing and Communication/Evidence Submission:

• Create and co-create medical content for patients, providers, and payers to ensure scientific rigor, balance, and impact; this includes but is not limited to medical responses, Field Medical Affairs slides (MSLs and MEDs), emerging digital assets, evidence submissions (compendia, pathways, guidelines, and payer policies), and reprint dissemination materials.

• Provide medical review and input on the development/use of scientific and promotional materials and handle review processes (PRC, RDC) in close partnership with Medical Partners

• May act as the chair of the Reprint Dissemination Committee for the assigned product(s) or therapeutic area

• Write, maintain, review, and edit global medical responses to meet the medical information needs of worldwide and local customers

• Perform ongoing literature surveillance across multiple sources; critically evaluate data from multiple sources to deliver on the objectives of Medical Information activities

• Identify and address training needs of MI staff, internal partners, or external vendors, including USMA Contact Center. Write, review, edit and deliver medical content for training purposes

• Provide clinical guidance and medical information to assist the resolution of escalated medical and access inquiries from the USMA contact center

• Conduct quality assurance of vendor calls to ensure clinical accuracy, legal, regulatory and general compliance with Genentech/Roche standards, policies, procedures and protocols

• Measure the impact of medical information, and communicate these findings to key partners to strengthen collaboration and trust

QUALIFICATIONS & EXPERIENCES:

• Advanced Clinical/Science Degree required (e.g. PharmD, PhD, MD, etc.)

• 5 or more years’ relevant industry work experience or is a recognized expert in the field

• 5 or more years’ medical communication experience

• 2 or more years’ clinical experience or equivalent experience

• Significant experience with all aspects of healthcare communications activities

• Experience in a role that provided deep insight into fostering customer engagement through content creation

• Demonstrated experience with strategic planning, prioritizing and management of high-level initiatives and projects

• Superb collaboration and communication (oral and written) skills in developing strong partnerships with cross-functional peers

• Proven track record of collaborating, coaching and influencing outcomes in complex organizations and cross-functional projects

• Proven track record of meeting or exceeding objectives and goals

• Shows a proactive drive to negotiate, influence, coach and advise teams and leaders to develop valuable solutions

• Embraces an agile mindset to create necessary processes to get things done. Embraces a growth mindset to adapt and iterate in order to meet customer needs. Knows how to organize people and activities effectively to achieve impactful outcomes

• Substantive understanding and exposure to corporate legal and compliance groups, and is knowledgeable of issues related to, GCP, OIG, US Regulatory/FDA requirements, drug access and other guiding or controlling elements of our business

• Complies with all laws, regulations, policies, and procedures that govern the conduct of GNE principles

CMG Operating Principles

I put the patient first, always.

I am tenacious in meeting customer needs.

I act on behalf of the whole company, not just my team.

I am inclusive.

I build a culture of trust.

I grow my capabilities to increase my impact.

I have a bias for action.

I am accountable.

I use time and resources to create the most impact.

I act with integrity.

Roche is an equal opportunity employer.

In US Medical Affairs (USMA), we focus on broadening opportunities for patient access by ensuring that health care stakeholders have the evidence they need on our products and the confidence in that evidence to make informed treatment decisions. As a key pillar in the broader Genentech organization, USMA has a pivotal role in bridging internal partner functions (including Research, Product Development, Commercial, and Government Affairs) and collaborating across the dynamic health ecosystem to ultimately deliver better patient outcomes while making care more accessible and affordable for all.

Position Overview:

The Product Lead in Medical Information – Solid Tumor is focused on developing the implementation plan as well as executing on content creation for multiple channels in a specific therapeutic area to assure scientifically accurate, impactful communications to patients, HCPs, and/or access stakeholders. Key responsibilities include planning, execution, creation, and review of scientific content for customer engagement, responding to medical and/or access inquiries, and strategic application of customer insights. You assure that the medical content provided via established and digital Medical Information channels as well as via the medical and commercial field interactions is strategically impactful, timely, accurate, and in a customer-focused format by:

• Planning, developing, and advancing the functional as well as influencing the cross-functional scientific communication strategies in support of the medical priorities of the Medical Network and the Squad in the assigned molecule/product area

• Acting as a Medical Information clinical expert of the assigned molecule/product area to internal and external customers, and as a medical communications expert in crafting medical content that is compliant and resonates with patients, HCPs, and/or access stakeholders; consistently approaching interactions with clinical integrity and the highest professional ethics in accordance with guidelines, direction, and key strategies

• Anticipating, identifying, articulating, and solving concerns on clinical, access, and operational issues (e.g., PI, PRC/RDC/MRT, pathways, guidelines, systems, processes) that impact Medical Information, Medical Affairs, and customers; and contributing to the development of new principles and concepts in solving these unusually complex problems

• Informing the development of Lifecycle/Medical Plans and medical initiatives to fill customer knowledge gaps through the strategic use of Medical Information/Medical Affairs insights

• Anticipating and applying an expert understanding of the medical information needs of worldwide customers and providing strategic responses to complex medical information requests with a highly developed knowledge of all customer types

• Independently leading departmental, cross-functional, and interdisciplinary team meetings and projects involved with complex issues, and contributing to inter- and intra-departmental business decisions

• Ensuring our partners have an understanding of the issue and the potential business impact of the key trends, themes or other evolutions in the external legal and regulatory landscape that relate to the work of Medical Information in the relevant therapeutic area(s)

• Identifying, influencing, and regularly checking in with external department leaders to understand their needs and perspectives as well as strengthen relationships to effectively move initiatives forward

• Ensuring assigned goals and objectives are met and that assigned work is completed on time, to high standards and within budget

Core Accountabilities:

Depending on the resource model for the assigned therapeutic area, you may perform or oversee the following activities:

 

Strategy/Planning:

• Drive communication and content plans of the assigned molecule/product to be strategically aligned with medical priorities, deliver impactful results, and push innovation in cross-functional teams solving for complex issues that impact patients, HCPs, and/or access stakeholders

• Partner with stakeholders across USMA, Genentech, and Roche to break down silos to achieve results for the medical priorities

• Lead the medical information launch plan and strategy for the assigned molecule or line extension by working collaboratively and efficiently with all internal team members, partners and stakeholders to meet the anticipated and known medical information needs of patients, HCPs, and/or access stakeholders

• Inform the development of medical plan strategies and tactics through the strategic use of Medical Information/Medical Affairs insights for assigned molecules/products

• Proactively research, analyze and communicate key trends, themes or other evolutions in the external legal, regulatory, and access landscape that relate to the work of Medical Information in the relevant therapeutic area(s); innovate, develop, and contribute to updating and implementing departmental policies, procedures, and guidelines based on this knowledge

• Work with medical science liaisons (MSLs), medical executive directors (MEDs), medical science directors/medical directors (MSDs/MDs), medical partners, and Publication Planning to develop, disseminate and manage the timelines for scientific content communications and other relevant research and data communications for assigned molecule/product

• Maintain an in-depth understanding of relevant medical strategy and clinical, patient/caregiver, payer, and healthcare/market landscape

Medical Writing and Communication/Evidence Submission:

• Create and co-create medical content for patients, providers, and payers to ensure scientific rigor, balance, and impact; this includes but is not limited to medical responses, Field Medical Affairs slides (MSLs and MEDs), emerging digital assets, evidence submissions (compendia, pathways, guidelines, and payer policies), and reprint dissemination materials.

• Provide medical review and input on the development/use of scientific and promotional materials and handle review processes (PRC, RDC) in close partnership with Medical Partners

• May act as the chair of the Reprint Dissemination Committee for the assigned product(s) or therapeutic area

• Write, maintain, review, and edit global medical responses to meet the medical information needs of worldwide and local customers

• Perform ongoing literature surveillance across multiple sources; critically evaluate data from multiple sources to deliver on the objectives of Medical Information activities

• Identify and address training needs of MI staff, internal partners, or external vendors, including USMA Contact Center. Write, review, edit and deliver medical content for training purposes

• Provide clinical guidance and medical information to assist the resolution of escalated medical and/or access inquiries from the USMA contact center

• Conduct quality assurance of vendor calls to ensure clinical accuracy, legal, regulatory and general compliance with Genentech/Roche standards, policies, procedures and protocols

• Measure the impact of medical information, and communicate these findings to key partners to strengthen collaboration and trust

QUALIFICATIONS & EXPERIENCES:

• Advanced Clinical/Science Degree required (e.g. PharmD, PhD, MD, etc.)

• 5 or more years’ relevant industry work experience or is a recognized expert in the field

• 5 or more years’ medical communication experience

• 2 or more years’ clinical experience or equivalent experience

• Significant experience with all aspects of healthcare communications activities

• Experience in a role that provided deep insight into fostering customer engagement through content creation

• Demonstrated experience with strategic planning, prioritizing and management of high-level initiatives and projects

• Superb collaboration and communication (oral and written) skills in developing strong partnerships with cross-functional peers

• Proven track record of collaborating, coaching and influencing outcomes in complex organizations and cross-functional projects

• Proven track record of meeting or exceeding objectives and goals

• Shows a proactive drive to negotiate, influence, coach and advise teams and leaders to develop valuable solutions

• Embraces an agile mindset to create necessary processes to get things done. Embraces a growth mindset to adapt and iterate in order to meet customer needs. Knows how to organize activities effectively to achieve impactful outcomes

• Substantive understanding and exposure to corporate legal and compliance groups, and is knowledgeable of issues related to, GCP, OIG, US Regulatory/FDA requirements, drug access and other guiding or controlling elements of our business

• Complies with all laws, regulations, policies, and procedures that govern the conduct of GNE principles

CMG Operating Principles

I put the patient first, always

I am obsessed with meeting customer needs

I act on behalf of the whole company, not just my team

I am inclusive

I have a growth mindset

I act with urgency

I am accountable

I radically simplify and prioritize for impact

I follow the science

I build our reputation

External Link: https://www.gene.com/careers/commercial-operating-principles

Local candidates only. No Relocation Available for this position.

As the Sr. Manager of Internal Communications, you will develop and implement internal communications strategies for the Genentech Early Clinical Development (ECD) organization to drive business performance, organizational culture and employee engagement.   You must have exceptional communication skills, be a critical and systems thinker, and have the capability to foster relationships at all levels. This role engages across and beyond the Early Clinical Development organization, including with senior leadership, to support the development of relevant, high impact communication strategy and tactics. 

This role offers a unique opportunity for the ideal candidate to drive strategy and senior leader communications, while working cross functionally to implement best-in-class organizational communications and change management practices.

This position reports to the Head of Knowledge Development, Management, and Communications for Genentech Early Clinical Development.  

Major Responsibilities:

As a member of the Knowledge Development, Management, and Communication team within Early Clinical Development’s Business Operation group, this role will work broadly across all Early Clinical Development functions as well as other partners in gRED and beyond.  This position is responsible to:

• Manage the execution of a communication, change, and engagement strategy that anticipates the changing nature of work, evolving employee needs/wants (customization of content, varied delivery), and an increasingly competitive landscape for recruitment and retention.

• Consult and support senior leaders and functions/teams within Early Clinical Development regarding leadership communications, channel usage, and change and engagement strategy and tactics. Partner closely with key stakeholders to develop internal messaging and communication plans that help drive results and advance strategic priorities and initiatives.  

• Develop a leadership narrative with the goal of shaping and influencing employee sentiment, building trust and confidence in Early Clinical Development’s leadership. Bring the leadership narrative to life through communications and engaging experiences including meetings, in-person and virtual events, and through rich digital/video storytelling to drive enterprise-wide understanding of key leadership priorities.

• Provide well-written, researched, validated, clear, consistent business communications on a range of topics that span organizational announcements, leadership communication, meeting presentations, multimedia, scripts, key messages and talking points

• Envision and oversee the development of experiences and events that positively engage Early Clinical Development employees. Ensuring continued innovation, inclusivity, creativity and strategic agility so that our programs remain fresh and compelling, and accessible, to all employees. Scope includes but is not limited to special events, patient speakers, celebrations, all-employee town halls, as well as envisioning and establishing new experiences and traditions for our employees.

• Manage internal communications editorial calendar.

• Set and assess success of communications and programs through metrics.

• Develop and execute communications in support of change management.

• Cultivate a mindset of experimentation, agility and smart risk taking across to drive innovation and creativity.

• Lead a team of communications professionals

Qualifications:

• BS/BA required

Experience:

• 8-10 years of experience in an executive communications role in a biotech, pharmaceutical or related life sciences organization

• Extensive experience developing communications strategies and plans

• Strong understanding of executive communications, employee engagement, channels and event management

• Experience change management strategies, activities, communications, and execution is preferred.

• Experience in the research/early discovery and development area is highly desirable

• Scientific or clinical background preferred

• Experience directly engaging with senior management with minimal oversight

• Experience as a people manager

To be successful the Senior Manager of Internal Communications must:

• Have a clear impact/results orientation and ability to set compelling goals, ensure clear accountabilities and grain alignment to deliver on commitments

• Translate scientific research into communications suitable for a broad audience

• Demonstrate change management communications expertise

• Demonstrate strong executive presence and cultivate trusted relationships with senior leaders

• Have outstanding communication and presentation skills, both written and verbal. Highly effective at distilling complex and sometimes voluminous content into clear, concise and engaging communications

• Demonstrate strategic agility. Has knowledge of the life sciences industry and is able to bring this knowledge to bear when advising stakeholders and partners on communication strategies, plans, objectives, tactics, implications and impact

• Demonstrate expertise developing employee engagement communications plans and campaigns, including knowing how to use creative design effectively to enhance engagement in corporate programs and innovative communications technology platforms to deliver compelling communications content

• Demonstrate strong consulting skills with the ability to quickly assimilate business needs and circumstances and effectively advise others

• Effectively advise internal stakeholders and partners on the most strategic, high-level or complex matters

• Showcase outstanding time management and organizational skills. Consistently executes multiple, and sometimes competing, activities and complex projects to a high quality conclusion, on-time, and within-budget

• Have strong customer-orientation and a proven track record of collaborative work relationships

• Be highly skilled at influencing without authority 

#InternalCommunications #Biotech #ScientificCommunications #SFBayArea

Start Date: Fall 2021

Work Hours: 40 hours per week 

Length of Assignment: 3 months  

Education Level: Bachelor's (must be enrolled in or completed their 2nd year), Master's, PhD, PharmD, OD

Preferred Majors/Disciplines: M.D., Ph.D., Pharm.D or OD students or recent graduates.

Given the current uncertainty of the global pandemic and work from home situation for 2021, this internship is currently planned to be virtual with the option for interns to work remotely from within the U.S. Borders. We will keep candidates informed if this changes. 

Due to the ever changing situation concerning the COVID-19 global pandemic, for our summer 2021 internship program we will only consider international candidates who are currently in the US and will remain in the US for the duration of the internship.

Job Description

Genentech has a strong commitment to developing novel, vision-changing therapies for patients with ophthalmic diseases. We are seeking a clinical science intern with life-science related education (ongoing or recent graduate) to join the Product Development Clinical Science Ophthalmology group at Genentech.

The internship will provide exposure to clinical science development and understanding the basic principles of clinical research. The intern will have the opportunity to contribute to multidisciplinary teams to progress science discoveries in ophthalmic disease(s). The intern will have an opportunity to lead an assigned research ophthalmology project culminating with a poster presentation and a talk to the Genentech team. The intern will also have an opportunity to participate, observe and learn from the team about a variety of clinical development activities:

• Learn and understand pathophysiology of ophthalmology diseases, current standard of care treatments and the unmet medical need in the real world Learn and understand the principles of scientific analysis and interpretation of data from clinical studies for molecules in development.

• Participate in key clinical strategy, implementation and molecule management meetings in order to gain a deeper understanding of the complexities and challenges of medicines development.

• Learn about therapeutic approaches and including gene therapy in ophthalmology Generate and present abstracts and oral presentations for internal meeting(s).

• Develop understanding of Good Clinical Practice (GCP), International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), FDA, EMA, NICE and other relevant guidelines and regulations .

Requirements/Qualifications

• Highly motivated candidates with life science related education.

• The candidate must demonstrate ability to evaluate, interpret and present scientific data in their past work (previous research experience preferred).

• Excellent presentation and communication skills.

Start Date: Fall 2021

Work Hours: 40 hours per week 

Length of Assignment: 1 year

Education Level: Completed Bachelor degree at a minimum

Preferred Majors/Disciplines:  Science degree - biology / pharmacy / biochemistry / anything with lab experience

Given the current uncertainty of the global pandemic and work from home situation for 2021, this internship is currently planned to be virtual with the option for interns to work remotely from within the U.S. Borders. We will keep candidates informed if this changes. 

Due to the ever changing situation concerning the COVID-19 global pandemic, for our summer 2021 internship program we will only consider international candidates who are currently in the US and will remain in the US for the duration of the internship.

PDG is accounting for developing and delivering patient-centered operations strategies to recruit and retain patients for Roche / Genentech for phase 1B through phase IV clinical trials, delivering data that improves health outcomes around the world. Biomarker Operations is a department that focuses on providing the biological specimens and samples to support current and future research programs.

https://pharma.roche.com/pd/clinical-operations-pdg/

Job Description:

Gain hands-on experience in the day-to-day activities within Biomarker Operations (BMO) while also obtaining a high-level understanding of the execution of clinical trials needed to bring drugs to patients. You will be given specific tasks to support teams and functional roles within the department. You will also have an opportunity to shadow and support individuals from the department to get exposure to the management of biomarker sample operations, the conduct of clinical trials, and gain experience in the interactions Biomarker Operations Project Managers (BOPMs) have with key stakeholders such as Biomarker Science, Study Management, and Biorepository Management to execute the strategies that will help to make our medicines more personalized for patients.

Main responsibilities

Within this role you will support a team(s) working on Phase Ib, Phase II and/or III clinical study protocols in Oncology and / or Immunology, Infectious Disease, Ophthalmology and Neuroscience (I2ON). The department, Global Product Development (Clinical Operations), works specifically on the operational element required to conduct global Phase Ib, Phase II or Phase III registration clinical trials for investigational new drugs. Biomarker Operations, a function of Clinical Operations, is accountable for planning, coordinating, and overseeing all operational activities required to manage the lifecycle of biomarker samples including collection, processing, analysis, data delivery, and final sample disposition.

Your responsibilities will include communicating with teams, maintaining central documentation, and assisting with the project setup within the Biomarker Operations group. Additionally you will contribute to a cross-functional initiative digitizing the planned sample collection schedules to enable future re-use in downstream processes. Specifically, you may be required to: Collect, qualify, manage, and track key biomarker and clinical data / metrics Organize and present data in meaningful and visually engaging tables, graphs, and slides that combine scientific and clinical information Create reports, analyses, and planning solutions based on provided data and audience Interact with internal and external scientific, operational, and vendor stakeholders Support regular activities within Biomarker Sub Teams such as data collection, analysis, and presentations Assist with organizing content related to compliance/ethics of sample use on a trial Engage study teams for the set up and the implementation of new digital tools to support biosample operational activities. Help review standard study related reports and liaise with accountable study members to address any inconsistencies and missing information, as appropriate Support Biomarker Operations Project Managers (BOPMs) to ensure essential study information is maintained and tracked Support the group to collect, report, and organize relevant information for functional projects that will enhance our processes.

Requirements/Qualifications

• Effective communication, organization, and time management skills.

• Advanced knowledge of Word, Excel, PowerPoint, Google tools.

• Excellent interpersonal skills.

• Attention to detail and adept at organizing large sets of data.

• The ability to work independently and proactively.

• Strong customer focus.

• Flexibility and the ability to interact well within a team setting.

Start Date: Fall 2021

Work Hours: 40 hours per week 

Length of Assignment: 1 year

Education Level: Bachelor's (must be enrolled in or completed their 2nd year), recent graduate

Given the current uncertainty of the global pandemic and work from home situation for 2021, this internship is currently planned to be virtual with the option for interns to work remotely from within the U.S. Borders. We will keep candidates informed if this changes. 

Due to the ever changing situation concerning the COVID-19 global pandemic, for our summer 2021 internship program we will only consider international candidates who are currently in the US and will remain in the US for the duration of the internship.

Clinical Operations in Product Development Global (PDG) is responsible for the effective planning, implementation and management of clinical trials on a global level. Teams managing the clinical trials are located in 5 headquarter sites across North America, Europe, and Asia. The clinical operations teams plan and deliver high quality clinical trials in accordance with Good Clinical Practice (GCP) standards and to evaluate the safety and efficacy of our molecules for numerous diseases including oncology, immunology, ophthalmology, respiratory, and psychiatric diseases. These programs meet scientific, medical, regulatory and patient demands for new and innovative medicines globally. The results of these studies may form the basis of regulatory and commercial approval of medicines.

Job Description

In the position of PDG Global Studies Manager Intern (PDG GSM Intern) you will have the opportunity to join cross functional clinical trial execution teams and play a key role in supporting activities across a broad range of topics, for one or more trials in various phases (Phase I – IV trials). In addition to supporting operations work within the department (PDG), you will also have the opportunity to meet, work and collaborate with colleagues outside of operations such as BioMetrics, Clinical Science, Drug Safety, Affiliate Clinical Operations in other countries and Business Insights and Analytics. Responsibilities: PDG GSM Interns will work closely with Global Studies Managers who are responsible for effective and efficient leadership and delivery of all operational components across study start up, conduct and close-out in accordance with the appropriate quality standards including Good Clinical Practice (GCP) and applicable regulations. PDG GSM Interns will have the opportunity to experience and contribute to the following clinical operations activities to ensure delivery during the lifecycle of phase I to IV studies:

• Development and management of study timelines, risk and quality plans and the evaluation of study resource needs

• Providing day-to-day operational management of CROs and vendors to ensure delivery against contracted scope of work

• Forecasting of clinical/non-clinical supplies

• Identifying areas of best practice, innovation and process improvements

• Ensuring study adherence to GCP and Standard Operations Procedures (SOPs)

• Non study related activities (examples: community forums, time bound working groups)

Requirements/Qualifications

• General knowledge of drug development process is a major plus

• Knowledge / familiarity with ICH/GCP guidelines and other regulations is a plus

• Have a growth mindset and excitement about learning through experience

• Strong planning, organizational and problem solving skills and the ability to manage multiple priorities

• Comfort and ability to perform in a fast paced, team orientated environment

• Experience and comfort developing relationships and fostering team collaborations in a remote working environment (i.e. working via Zoom, Google Hangouts and other similar platforms)

• As reasonable, willingness to flex your business hours occasionally to accommodate and collaborate with colleagues in time zones around the globe

Start Date: Fall 2021

Work Hours: 40 hours per week 

Length of Assignment: 3 months

Education Level: Master's, PhD

Preferred Majors/Disciplines: Computer Science, Computer Engineering, Biomedical Engineering, Bioinformatics or other related science and engineering majors.

Given the current uncertainty of the global pandemic and work from home situation for 2021, this internship is currently planned to be virtual with the option for interns to work remotely from within the U.S. Borders. We will keep candidates informed if this changes. 

Due to the ever changing situation concerning the COVID-19 global pandemic, for our summer 2021 internship program we will only consider international candidates who are currently in the US and will remain in the US for the duration of the internship.

We partner to access complex datasets and leverage external technologies to enable advanced imaging applications. Advanced Analytics can be used to generate actionable insights from meaningful data at scale to accelerate R&D and improve patient outcomes. Leveraging advanced image analytics and data on cutting-edge data platforms, we develop innovative tools that enable faster and more accurate detection, characterization and monitoring of complex diseases across therapeutic areas. We aim to accelerate and improve the drug development process by:

• Accelerating or eliminating manual central review, reducing costs, subjectivity, and variability.

• Developing more informative and robust endpoints Improved diagnostic tools Creating automated assessments for RWD.

• Creating tools to help clinicians to select optimal therapies.

Job Description

This role within the Personalized Healthcare Data Science Imaging group has a focus on Data Science.

To contribute to the development of Machine Learning and/or Computer Vision algorithms applied to Clinical/Medical Imaging.

To work on algorithm development and validation tasks for instance End-to-end classification/regression, segmentation, registration, radiomics and feature extraction, in disease areas or modalities of Ophthalmology.

To develop and apply AI/CV methods on large data sets of 3D/2D clinical images (OCT, Color Fundus Photographs)

The developed methods will be applied for patient screening, diagnosis, disease assessment, evaluation of the therapeutic efficacy and/or safety, prediction of prognosis and/or response to therapy with significant business and scientific impact.

Requirements/Qualifications

• Strong programming skill in Python, hands-on experience of Deep Learning frameworks (TensorFlow, PyTorch, Keras), and familiarity with cloud/scientific computing environments (AWS, HPC) are required for the internship.

• Experience with image processing, computer vision, retinal imaging is a plus.

Sobre a Roche Diagnóstica

A Roche Diagnóstica,  líder mundial em diagnósticos in vitro, dedica-se a soluções de diagnóstico laboratorial. Atuamos para oferecer produtos e serviços exclusivos, além de testes inovadores para pesquisadores, médicos, pacientes, hospitais e laboratórios.

Sobre o seu Perfil

• Estudantes de Administração, Comércio Exterior, Logística e cursos relacionados, com disponibilidade para estagiar 30 horas semanais (6 horas por dia) e graduação em 2023;
• Conhecimentos de informática: Excel (intermediário – avançado); Power Point (intermediário – avançado);
• Inglês intermediário.

Sobre a Posição

• Realizar o atendimento aos clientes, acompanhando o processo de pedidos, desde a solicitação até sua entrega;
• Monitorar e encaminhar as necessidades do clientes para as áreas responsáveis; Registrar e monitorar reclamações dos clientes resolvendo-as no prazo determinado;
• Elaborar relatórios diversos.

Therapeutic Area Manager (TAM), West Central Florida

Territory Covers: West Central Florida.  Ideally candidate would live in Tampa or Sarasota or surrounding city.

Therapeutic area: Oncology (Hematology)

Position Overview:

From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a single purpose and an ambitious vision. Together, we aspire to deliver ever better health outcomes for patients while lowering overall healthcare costs.

The Therapeutic Area Manager (TAM) is integral to successfully delivering this vision, working closely with healthcare providers. The TAM deeply understands the specific needs of healthcare practitioners in their therapeutic area to identify and address their clinical and business goals and challenges in support of improved patient outcomes, lower costs and improved quality of care. 

The TAM is empowered to own the business for their TA within the ecosystem and to optimize as appropriate; focused on improving the customer and patient experience across the care continuum. They will leverage other ecosystem and organization experts to provide customers with the information they need about products to make decisions that support enhanced patient outcomes, and to influence the ecosystem business strategy. The TAM will represent all relevant products and indications within the designated Therapeutic Area. 

In alignment with the ecosystem and customer strategic plan, the TAM is accountable for driving on-label clinical demand to ensure HCPs identify the right medication for the right patient.

In addition, they are responsible for collecting ecosystem insights and trends and being a primary conduit between an ecosystem, the Squads and marketing to support the national strategy at a local level.  The TAM will represent the Genentech products to the highest ethical and professional standards and in accordance with guidelines and PRC approved materials.

There are two levels of Therapeutic Area Managers. The difference is based on the scope, complexity and criticality to the ecosystem business as well as differences in expertise required to execute responsibilities.

Key Accountabilities

• Serve as primary point of contact for their therapeutic area for their customers in the ecosystem. Address and identify opportunities for pulling through ecosystem and TA squad strategies at the point-of-care
• Apply strong understanding of the specific needs of healthcare practitioners and mobilizes ecosystem and organization experts to partner with customers to identify and address their clinical and business goals and challenges in support of improved patient outcomes, lower costs and improved quality of care 
• Contribute to the development and execution of customer account plans for target accounts to deliver maximum impact opportunities and business goals 
• Deliver education to HCPs regarding product information, appropriate use, and dosing and administration based on FDA approved product information and formulary/pathways/guidelines (e.g. one on one interactions, in-services, identification of opportunities for peer-to-peer programming, etc.). Effectively triage to USMA experts as appropriate
• Address product acquisition (contract awareness, etc), and address supply matters through coordination of  distribution issues, and managing spoilage and returns
• Ensure product access to provide proactive (and de-identified) education on patient assistance, reimbursement resources. Triage to HD and FRM as appropriate
• Keep abreast of customer and healthcare industry trends. Initiates development actions to constantly adapt and grow capabilities to increase impact
• Represent the Genentech products to the highest ethical and professional standards and in accordance with guidelines and PRC approved materials
• Lead, act and live our Operating Principles in all aspects of work

Qualifications

• Scientific or clinical degree, Bachelor’s degree level at minimum
• Previous cross-functional industry experience in commercial life sciences (pharma or biotechnology) or related industry engaging with key healthcare ecosystem players (e.g., payers, health systems), is required
• 4 or more years experience working in a sales role with HCPs, ideally representing multiple products and working across a complex healthcare system environment
• You have sold specialty drugs before, have product launch experience and may have specific hemophilia, rare disease and/or orphan drug experience
• Clinical nurse or Advanced Practice Nurse (APN) experience highly valued
• Ability to work in an ambiguous environment undergoing transformation is a strong plus
• Proven track record in coaching, training and/or mentoring peers or others as assigned; helping such others to better meet or exceed their goals, targets and other responsibilities
• Proven track record for consistently meeting or exceeding financial and/or other quantitative targets, as well as qualitative goals
• Self starter; ability to seek out relevant information, prioritize, and apply information to solve complex problems in the ecosystem 
• Ability to assimilate and communicate complex clinical and product information 
• Knowledge of and ability to successfully addressing operational issues in the delivery of healthcare products to patients, such as reimbursement and supply
• Understanding of external laws, codes and company policies that apply to the healthcare industry

Operating Principles

I put the patient first, always. 

I am obsessed with meeting customer needs. 

I act on behalf of the whole company, not just my team. 

I am inclusive.  

I build a culture of trust. 

I have a growth mindset. 

I act with urgency. 

I am accountable. 

I radically simplify and prioritize for impact. 

I follow the science.

I build our reputation.

Complies with all laws, regulations, policies and procedures that govern the conduct of Genentech activities.

It is highly preferred the candidate live within the ecosystem. 

This is a field-based position and overnight travel may be required. This position requires significant driving of either a company provided or personal vehicle as well as prolonged periods of sitting, both of which are part of the essential duties and responsibilities of the role. As a result, Genentech, Inc. (Company) from time to time will check your motor vehicle record for purposes of determining your eligibility for driving a Company vehicle or driving any vehicle on Company business. 

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society.   Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

#LI-TW1

Position Summary

The Product Marketing organization establishes the full product value proposition and product positioning for all customer types. The Marketing organization is also accountable to design outstanding customer experiences and works with networked partners (e.g. Field, Genentech Business Operations) to deliver these experiences. A marketer uses resources and their network to make meaningful progress with patients and customers each day.

This individual also lives the CMG Operating Principles: (I put the patient first always; I am tenacious in meeting customer needs; I act on behalf of the whole company, not just my own team; I am accountable; I use time and resources to create the most impact; I am inclusive; I have a bias for action; I build a culture of trust; My career will thrive as I grow my capabilities and increase my impact; I act with integrity).

Key Job Responsibilities

Supports the development and execution of the Hematology value proposition, customer positioning, and the end-to-end customer experience

• Engage with networked partners (i.e.: T&D, Analytics, Operations) and ecosystem leadership to support customer readiness for relevant ecosystem roles.  Drive pull through of national Squad Strategy, messaging and resource utilization through leadership of TA Communities of Practice and support of ecosystem planning and regular business reviews
• Build innovative end-to-end customer solutions / services that optimize local opportunities falling within the overall brand priorities
• Capture national and ecosystem TA related healthcare trends and insights, assessing their implications to Genentech’s portfolio and the Squad Strategic Plan.
• With an enterprise mindset and focus on Triple Aim, work collaboratively across multiple squads, ecosystems and internal functional groups to integrate brand strategy and tactics into the story of the strength of Genentech’s Portfolio as a partner (i.e.: cross squad initiatives for advocacy groups or large, integrated customers)
• Uses and commissions appropriate marketing research needed to drive the product's overall market positioning and to inform the optimal end-to-end customer experience
• Identifies and works regularly with internal network partners and external resources to deliver product marketing activities  
• Responsible for ensuring a seamless, well-integrated product message and position across multiple marketing platforms
• Accountable for high quality, compliant execution across all marketing platforms and customer types (e.g. patients, providers, organized customers)
• Prioritizes and creates personal messages and resources for field-based channels in coordination with non-personal messages and resources
• Monitors marketing activity usage, performance, and customer satisfaction to optimize campaigns and drive customer and business outcomes
• Partners with the Promotional Review Committee (PRC), including Legal and Regulatory, to ensure development, approval, and pull-through of compliant and effective promotional tactics
• Leads and/or participates in flexibly deployed work teams across the CMG network, contributing novel ideas or approaches based on their areas of expertise
• Works autonomously to make decisions and act, in close alignment with the full product value proposition, customer positioning, and Squad priorities

Demonstrates Proficiency within the following Key Capability Areas

• Customer, Product and Market Insights:  Ability to understand, integrate and synthesize insights across customers, competitors, therapeutic or business areas and markets to inform customer-centric business decisions Collaborates with all ecosystem personnel to capture and assess local insights, reporting findings and implications back to the Squad.  The senior EM combines internal resources (Insights tool, ecosystem plans) as well as Integrated/Large account information (i.e.: annual report)  to assess implications and identify opportunities across multiple ecosystems and squads. Engages across functional teams (Portfolio Marketing, Analytics, Ecosystem Operations) to support ecosystem and account level planning
• Financial Acumen:  Ability to use financial information and capabilities to inform investment decisions, manage external partners and budgets, and drive sound business decisions
• Value Creation: Ability to develop and communicate the unique value and promise that Genentech’s products and solutions provide to its customers; Strong agency management skills
• Business Strategy: Ability to make choices and identify key metrics to deliver measurable customer and financial objectives that drive business forward.
• Customer Experience: Ability to create and execute customer-centric programs and solutions to positively and meaningfully engage customers across the care continuum
• Market Execution: Ability to create, implement and iterate impactful tactics with clear and measurable outcomes to the business and the customer. Ensures clear communication and pull through of national strategy, messaging and resources at the local level (i.e.: through CoPs. Regional QBRs, reactive account visits, etc). Engages as strategic partner to ecosystem leadership and IC roles for creation of local tactics and strategies.  Partners with internal functions to pull through high impact opportunities  (i.e.: Advocacy, SBS, PRC, gFRS). Partners with HD to ensure customer readiness for all TA aligned roles (i.e.: new TAM hiring, NME or indication launch, deployment of new resource, initiative or messaging).  Engages with T&D and other functional partners to ensure 
• Account Marketing and Partnerships: Ability to identify, develop and maximize effective working relationships with customers and partners to gain alignment on customer needs and optimize business and customer outcomes. Embraces the enterprise mindset and demonstrates ability to align across all functions. Communicates the power of Genentech as a partner as well as the full suite of patient support services. Engages in cross-Squad and cross-Ecosystem activities to leverage insights across the Portfolio and able to Connect portfolio opportunities to market trends.  Shares findings with key field stakeholders to accomplish shared objectives. Optimize relationships with existing customers/key stakeholders and/or seek new and innovative partnerships to execute on Genentech’s long-term strategy and serve the evolving needs of a diverse customer base

Skills and Competencies

• Strong working knowledge of all aspects of brand marketing including positioning, branding, campaign development and channel mix

• Knowledge of the healthcare ecosystem including health economics, policy and the regulatory environment

• Knowledge of each critical customer type e.g. patients, providers, organized customers as well as their experiences and their needs end-to-end

• Ability to think with an enterprise mindset

• Ability to influence and inspire individuals and teams across the CMG network

• Breadth of experience in product/therapeutic area, access marketing and multichannel marketing

• Ability to flex and thrive in an ambiguous environment undergoing transformational change

• Strong customer orientation and focus

• Strong analytical skills to effectively utilize research and behavioral data to shape strategies and tactics

• Strong agency management skills

• Ability to translate strategic direction into action plan for self, and make progress in the face of ambiguity

• Good judgment in recognizing the distinction between "good enough" and perfection

• Embraces change, embodies a continuous improvement mindset, and exemplifies agile principles in day-to-day activities

Location

. Candidate can reside in South San Francisco OR

• Candidate must reside within the Mid-Atlantic Region (MD, Washington D.C., VA, KY, W. VA, TN, KS, MO, NC, SC, IN and South IL)

Qualifications

• Bachelor's degree in Marketing / Business preferred

• MBA, PharmD, or other related graduate level degree preferred

Experience

• 12-15 years of experience with the majority working in a product marketing function

• Experience in the managed care, pharmaceutical or biotech industry/pharmaceutical or biotech field sales

• Marketing experience in other relevant industries

• Experience in creating marketing strategies, plans and tactics that have strengthened market positioning and driven high-value customer and business outcomes

#LI-OC

The Department of Cellular and Tissue Genomics within Genentech Research and Early Development is seeking a highly talented, creative and driven Scientist to generate and utilize high content perturbation maps for biological and drug discovery and to develop novel technologies for high information content screening.

This individual will lead an independent research group whose mission is to develop and apply scalable tools for screens for complex biological phenotypes. The experimental and computational toolbox developed should create a path to comprehensively characterize cell and tissue circuits at the single cell level, and to better understand the function of genetic variants in complex diseases. 

The scope of the screening activities will span biological disciplines,  including immunology, molecular oncology, cancer immunology, angiogenesis, neurobiology and regenerative medicine. The scientists will play a key role in leading and contributing to teams in disease areas of focus. They will apply these tools to perform cutting edge screens to identify novel therapeutic targets and next-generation biomarkers to enable precision medicine therapies for patients.

Responsibilities

• Pursue scalable tools enabling pooled genome-wide and combinatorial high information content single-cell screens in biologically relevant models (e.g. patient cells, in vivo, organoids)

• Develop new screening modalities by combining an expanding perturbation toolkit (e.g. gene editing, epigenome editing, base editing, overexpression) with cutting-edge information-rich single-cell read-outs (e.g. RNA, chromatin, protein, morphology, lineage fate)

• Collaborate with disease experts across the different therapeutic areas to design screens tailored to biological discovery capturing physiology of disease

• Work together with machine learning teams to develop and apply models to describe molecular circuitry and identify new biomarkers and therapeutic targets

• Analyze available datasets or profile clinical trial samples to inform screen design for biomarker and drug discovery

• Mentor colleagues to enable their scientific potential

• Publish in high quality scientific journals and present externally though presentations at key internal and external meetings, advisory boards, and conferences

Qualifications

• Ph.D. with relevant postdoctoral experience gaining both experimental and computational expertise in genetics and systems biology using single-cell RNA-seq (scRNA-seq) methods

• Strong publication record of impactful discoveries that reveal novel biological pathways and/or advanced technologies to enable biological discovery

• Experience with performing large scale single cell screens (e.g. Perturb-Seq) collecting multimodal single-cell readouts (chromatin, RNA, protein, optical) in various settings including in vivo, ex vivo, and cell line systems

• Experience with inventing and deploying new single-cell screening methods (e.g. split-pool, ASAP-Seq, SHARE-Seq)

• Experience applying diverse CRISPR technologies (CRISPR gene editing, activation, repression) in vivo, ex vivo, and in cell lines

• Proficient in computational biology including high throughput omics (including scRNA-seq), visualization, and interpretation

• Excellent interpersonal skills with demonstrated ability to work within a team comprised of diverse expertise

• Excellent mentoring skills across all levels

• Excellent oral and written presentation skills

Seeking an independent and creative researcher for a Postdoctoral training position in the Ye lab to study the interaction among various cell types in cancer and inflammation. There are three potential areas of pursue for this candidate:

1. Interaction between immune cells and tumor blood vessels.

2. The role of Wnt signaling in different subtypes of colorectal cancer.

3. Adhesion receptor signaling in T cells.

Who You Are

• Candidate should have a doctoral degree in one of the following fields: Immunology, Vascular Biology, Cancer biology, Cell Biology, Molecular Biology, Developmental Biology, or Biochemistry. Working experience in cancer biology, Wnt signaling, or immunology are preferred. Bioinformatics skills especially in analyzing large data sets are desirable but not required.
• Enthusiasm in tackling complex biological problems, vigorous scientific logics, willingness to dedicate exceptional amount of efforts and time to bench research, and solid technical skills are essential qualities.
• Qualified candidates must have strong publication record to demonstrate productivity and independent thinking.

For information about Weilan Ye's Lab at Genentech, please go to:

http://www.gene.com/scientists/our-scientists/weilan-ye

For information about the Postdoctoral Program at Genentech, please go to: 

https://www.gene.com/careers/university-and-early-career/postdocs

#L1-SN1

#postdoc

The primary mission of the Genentech Research & Early Development (gRED) organization is to discover and develop promising molecule candidates as potential new medicines for patients. The Peptide Synthesis Lab is responsible for synthesizing, purifying and characterizing peptides and peptidomimetics in support of Genentech drug discovery in various departments including gRED and Pharmaceutical Technology Development (PTD).

We are looking for a highly experienced, strong collaborator and team player who works well with others in a diverse and inclusive environment, and is passionate about science and novel technologies to enable drug discovery efforts.

Responsibilities

• A full time position in the Peptide Synthesis Lab, Department of Early Discovery Biochemistry.
• The candidate will be working as a part of a team that focuses on synthesis, purification, characterization and documentation of peptides. 
• The successful candidate will operate and maintain multiple instruments including peptide synthesizers, HPLC, LC-MS, etc.
• The successful candidate will be focusing on high-throughput automated peptide synthesis employing Prelude X, Symphony X, Syro II and Liberty Blue microwave synthesizer.

Qualifications

Minimum Qualifications:

• BSc or MS in organic chemistry or chemical engineering and at least 3 years of relevant experience.
• Precise record keeping, attentiveness to details, organizational skills and familiarity with computer/database software (including Excel, Word, PowerPoint and ChemDraw).
• Excellent communication skills, flexibility, work drive and an eagerness to learn.
• Must be willing to work with potentially hazardous materials, adhering to health and safety guidelines.
• Candidate should possess expertise in peptide synthesis, synthetic organic chemistry, parallel and sequential synthesis, compound purification (including flash chromatography and reverse-phase HPLC purification) and structural characterization of peptides.

Preferred Qualifications:

• In-depth knowledge and hands-on experience with solid-phase and solution-phase peptide synthetic techniques, and the operation and maintenance of automated solid-phase peptide synthesis equipment.

#LI-JD1

The Department of Discovery Oncology at Genentech is seeking a highly talented, creative and motivated Principal Scientific Researcher (PSR) to establish, characterize and functionally interrogate patient derived organoids (PDO) with specific emphasis in gastrointestinal cancers that display aberrant regulation of the Wnt signaling pathway.

The successful candidate will define the best organoid growth conditions to enable a broad range of technologies, such as CRISPR based or small molecule screens, imaging and single cell genomics on PDO. In addition, a variety of genetic, biochemical, cell biological and structural techniques will then be used for target identification and pursuit of the underlying mechanistic link to disease. Candidates with a good understanding of the mechanistic process that drive cancer progression and/or experience primary/3D culture system to study pathways involved in tumor cell growth are encouraged to apply. This is an ideal position for someone who enjoys the translational aspects of converting basic biology discoveries in cancer development into drug discovery programs and who thrives in a team environment.

Who You Are:

• Qualified candidates will hold a doctoral degree in Cell Biology, Molecular Biology, Structural biology or Biochemistry and have a successful track record as illustrated by a publication record

• 2+ years of industry experience including proficiency in a broad range of biochemical, molecular, and cell biological techniques.

• Key technical skills include:

o Primary organoid engineering using both lentiviral and CRISPR-based approaches.

o Functional genomic screening techniques, both RNAi and CRISPR.

o Cell proliferation assays

o Biochemical techniques including western blotting, co-immunoprecipitation, and in vitro assays using purified components.

• Good organizational, problem-solving, and verbal/written communication skills.

• Ability and desire to work both independently and collaboratively in a dynamic research environment.

TransformD: Provider Insights Software Lead, Roche Information Solutions

Role Purpose

As the Provider Insights Software Lead, you will be responsible for driving customer and business value through leading the end-to-end software delivery of our Provider Insights portfolio (excludes Oncology portfolio). You will be in a key team leadership role to help shape and enable the RIS Architecture & Software organization’s strategy and contribute to the overall Roche Diagnostics vision. 

You will provide effective leadership for the team in a manner that is consistent with the Roche values and leadership commitments. You will seek to inspire and lead your team to create transformative solutions ensuring that Information Solutions products are recognized as being the best in the Diagnostics industry and maintain our #1 ranking in the future.

Reporting to the Head of Architecture & Software in Roche Information Solutions (RIS), you will primarily partner with the rest of Engineering, Customer Areas, Data Services, Commercial, and Marketing & Services functions in RIS to deliver customer centric solutions.  

In this role, you will:

• Accountable for the development, Verification and validation, products architecture, DevOps, documentation, and localization for the Provider Insights portfolio which includes Healthcare Insights, IRIS Enterprise and Translational Research, and Analytics Framework

• This is a people management role which requires the ability to hire and grow top engineering talent, leading multiple teams and individuals (including managers and senior technical leaders) to work efficiently together

• Responsible for technical delivery of software for the team, including quality and predictability

• Proactively takes on improvement initiatives and leads process improvements (Agile, QMS alignment)

• Able to scale strategically to take on multiple projects, align across DIS portfolio, build and drive a technology roadmap, manage cross-functional and internal (Roche) and external) stakeholders  

Who you are:

• BS degree or equivalent in a directly related discipline (CS, Eng, etc.)

• 7 - 12 years of previous software development/architecture experience

• At least 5 years of people management experience

• Have successfully built, deployed, and supported an enterprise-scale web application in the cloud (in a leadership role)

• Proven ability to lead multiple, globally distributed software engineering teams to on-time, on-budget delivery

• Hands-on software development experience in either Java or C++/C# with expertise in at least one 

• Strong experience in Machine Learning (ML) and ML algorithm development and deployment 

• Background in Image Processing

• Experience leading DevOps teams

• Experience in healthcare is not required, but familiarity with healthcare systems and data and workflows is a plus (e.g. HL7, IHE)

• Quick learner with the ability to understand complex workflows and develop and validate innovative solutions to solve difficult problems

• Good communicator, able to talk with stakeholders and customers to explain technology and with the proven ability to take insights from customers and translate them into technical deliverables

• Proven ability to establish and articulate a vision, set goals, develop and execute strategies, and track and measure results

• Proven experience leading software teams through collaborative technological innovation in an agile environment or continuous improvement efforts that have yielded tangible results and/or positive impact for patients or business stakeholders

• Highly developed leadership and people influencing skills; Demonstrated success in establishing a high performing environment, catalyzing [email protected] cultural dimensions, with an excellent reputation attracting the best talent and the commitment to developing and inspiring them

• Proven ability to create and sustain strong collaborative relationships and networks with diverse stakeholders across a complex global organization

• Intrapreneurial mindset with proven ability to incubate and foster agile organizations within a complex, global corporate environment

• Familiarity with the technological trends and their relevance to the healthcare industry. A passionate and decisive business leader. Demonstrating courage, vision and drive to achieve results at the forefront of innovative technological changes

Locations:

You can be based in Santa Clara

At the Company's discretion, an exception to the location requirement could be made under extraordinary circumstances.  

As this position is a global role, international business travel will be required depending upon the business location of the successful candidate and ongoing business project activities.

Roche is strongly committed to a diverse and inclusive workplace. We strive to build teams that represent a range of backgrounds, perspectives, and skills. Embracing diversity enables us to create a great place to work and to innovate for patients

POSITION SUMMARY

Roche Diagnostics acquired Stratos Genomics (SBX Nanopore Sequencing) in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by eXpansion (SBX™). You will engineer and synthesize the molecular building blocks for our novel technology.   These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.   

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes.  We are looking for people who are excited about the significance of our technology and want to make SBX successful. 

Please include a cover letter outlining why you want to work with us, your specific interest in our technology and how you would contribute, this is important.

ESSENTIAL FUNCTIONS

• Develop novel methods on our automated synthesizers 

• Develop PM/PQ processes for complex scientific equipment

• Propose and execute high quality laboratory experiments

• Identify and troubleshoot problems in creative ways

• Contribute to the definition and timely achievement of project goals

• Follow SOPs to aid in the production of reagents and starting materials

• Perform data analysis and protocol development

• Maintain accurate, detailed and reliable laboratory records

• Present findings at group or departmental meetings

• Maintain the lab’s cleanliness and organization

• Develop and propose improved processes to fulfill the above functions

• Other duties as assigned

EDUCATION & EXPERIENCE

• Bachelor’s degree in Biological/Life Sciences, Chemistry, Organic Chemistry, Chemical or Mechanical Engineering, Biochemistry or related field, or equivalent combination of education and work experience, MS or PHD Preferred. 2+ years of industry experience, less with advanced degrees or demonstrated capability.

• Minimum of 2 years laboratory experience with complex DNA/RNA oligo-synthesis and processing

• Ideal candidates will have:

  • Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage

  • Technical background in next-generation DNA sequencing

  • Experience with HPLC, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting

  • interest in the scientific and technical aspects of machinery and instrumentation, including programing complex automation systems

  • Comfort with a coding language (e.g., Python, MatLab, VBA, etc.)

POSITION SUMMARY

Roche Diagnostics acquired Stratos Genomics (SBX Nanopore Sequencing) in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by eXpansion (SBX™). You will engineer and synthesize the molecular building blocks for our novel technology.   These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.   

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes.  We are looking for people who are excited about the significance of our technology and want to make SBX successful. 

Please include a cover letter outlining why you want to work with us, your specific interest in our technology and how you would contribute, this is important.

ESSENTIAL FUNCTIONS

• Develop novel methods on our automated synthesizers 

• Develop PM/PQ processes for complex scientific equipment

• Propose and execute high quality laboratory experiments

• Identify and troubleshoot problems in creative ways

• Contribute to the definition and timely achievement of project goals

• Follow SOPs to aid in the production of reagents and starting materials

• Perform data analysis and protocol development

• Maintain accurate, detailed and reliable laboratory records

• Present findings at group or departmental meetings

• Maintain the lab’s cleanliness and organization

• Develop and propose improved processes to fulfill the above functions

• Other duties as assigned

EDUCATION & EXPERIENCE

• Bachelor’s degree in Biological/Life Sciences, Chemistry, Organic Chemistry, Chemical or Mechanical Engineering, Biochemistry or related field, or equivalent combination of education and work experience, MS or PHD Preferred. 2+ years of industry experience, less with advanced degrees or demonstrated capability.

• Minimum of 2 years laboratory experience with complex DNA/RNA oligo-synthesis and processing

• Ideal candidates will have:

  • Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage

  • Technical background in next-generation DNA sequencing

  • Experience with HPLC, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting

  • interest in the scientific and technical aspects of machinery and instrumentation, including programing complex automation systems

  • Comfort with a coding language (e.g., Python, MatLab, VBA, etc.)

We are looking for a highly motivated and talented individual to lead our CRO strategy and operations efforts within the Drug Metabolism and Pharmacokinetics (DMPK) department.  DMPK supports projects from early stage research to NDA and beyond.  DMPK uses outsourcing as a key strategic lever to provide high quality support for all of our portfolio projects.  DMPK supported activities are outsourced to highly collaborative full time employee based teams as well as through numerous fee-for-service contracts.  This position requires excellent strategic thinking and project management skills to ensure operational excellence and awareness/planning of future outsourcing opportunities that enhance our capabilities while managing operational risks.  This individual work closely with scientific, technical and operational experts in DMPK and with other departments such as Research Contracts and Procurement who will provide additional logistical support.  Finally, the candidate will work closely with the Associate Director of Small Molecule Outsourcing and other outsourcing managers within Small Molecule Drug Discovery (SMDD) to support our extensive worldwide CRO partnerships.

Responsibilities:

• Serve as the key manager and coordinator of all DMPK outsourcing activities, in particular for our large FTE and FFS arrangements.

• Establish long-range strategic outsourcing plan that complements our in house capabilities, addresses operational risks and capitalizes on external opportunities.

• Provide strategic and operational guidance ensuring CROs’ capability, capacity, and lead-time meet Genentech requirements.  In collaboration with the DMPK leadership team and technical experts, ensure appropriate staffing levels for outsourced activities. 

• Be the liaison for all of DMPK when interfacing with CROs.

• Facilitate regular communications, virtual and face-to-face, between DMPK and CROs and serve as the interface between the technical experts and CROs.

• In collaboration with technical experts in DMPK, help establish key performance indicators (KPIs); as well as, track, identify, track and communicate operational gaps.

• In collaboration with technical experts in DMPK, regularly review risks and mitigation strategies associated with our outsourced activities.

• Assist technical experts with identification of new outsourcing opportunities and externalization of assays to CROs.

• Work closely with the SMDD outsourcing group to proactively develop outsourcing strategies that coordinate activities across SMDD to ensure operational efficiency and rapid progression of compounds through testing cascades.

• Interact with senior leaders in SMDD and elsewhere on CRO management.

• Keep abreast of technical developments in the field and influence CROs to build relevant capabilities.  Monitor industry trends.

• May supervise direct reports.

Requirements:

• B.S. or PhD/MBA in business management and/or STEM with a minimum of 7 years of experience in managing outsourcing activities in drug discovery and development, e.g. outsourcing, procurement, or CRO business development.

• In depth knowledge of DMPK, drug discovery and development, management experience and project management accreditation (PMP) are highly desirable.

• In depth knowledge / use of Smartsheet, Trello, Workfront, MS Project or other project / task management software is highly desirable.

• Demonstrated ability to establish long-range strategic plans that capitalize on internal needs and external capabilities while managing operational risks.

• Demonstrated ability to establish and track KPIs to ensure operational excellence.

• Outstanding interpersonal skills to establish and maintain close and effective working relationships with internal stakeholders in DMPK and SMDD, CROs, and cross-functional and cross-cultural teams.

• Evidence of strong negotiation skills with the ability to identify and implement desirable solutions to strategic and operational challenges as well as manage conflict.

• Proven ability to lead people, groups, and teams.

• Excellent oral/written communication and organizational skills.

• Excellent judgment and demonstrated analytical ability and problem-solving skills.

• Attention to detail, accuracy, and timelines. 

• Available for travel both domestic and international.

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Genentech has an outstanding opportunity for a motivated and highly accomplished scientist to lead our Oncology Computational Biology department. The successful candidate will be responsible for developing a vision and strategy to guide computational biology efforts for target and diagnostic discovery in support of Oncology drug discovery and translational research efforts. He/she will be responsible for working closely with oncology research therapeutic area leaders and core function stakeholders to guide our scientific efforts and support our oncology drug development pipeline. The position leads a diverse group of over 50 highly talented internal and external staff, contributing to computational projects across multiple departments in Research, Development Sciences, and Clinical Development. 

At Genentech, patients are at the forefront of everything we do. We are a leader in the development and application of computational methods to research problems in drug discovery and development, and we have extensive resources for computational support and data analysis. This position offers the rewarding opportunity to do work that directly impacts patients, and to work in an environment that fosters a culture of scientific investigation and publication.

Qualified candidates will meet the following requirements:

• Ph.D. in Biology, Bioinformatics, Statistics, or related field, with a minimum 15 years of experience in computational biology and bioinformatics
• World-renowned reputation as a leader in computational biology and bioinformatics.
• Proven record developing strategic vision leveraging computational biology to alter the paradigm for target and diagnostic discovery to support drug discovery and development efforts
• Strong publication record in peer-reviewed journals, as evidenced by multiple senior-author publications in top scientific journals
• Proven ability to mentor and develop world class talent
• Excellent leadership capabilities with demonstrated skill in building, guiding and motivating effective teams and fostering productive research collaborations
• Outstanding communication and partnering skills

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#gREDinformatics