|Date||Job Title||Job Level||Location|
|10/26/20||Postdoctoral Fellow – Structural Biology, Matsumoto Lab||Entry Level||South San Francisco, California|
The Matsumoto lab, within the Structural Biology Department at Genentech, is seeking an innovative postdoctoral fellow to pursue engineering and structural characterization of immunoglobulins and their interactions with various cellular receptors and antigens. The postdoc will use protein engineering paired with X-ray crystallography and/or cryo-electron microscopy (cryo-EM) to explore various immunoglobulin formats for technology development and potential therapeutic applications. He/she will structurally characterize complexes of immunoglobulins with their receptors to elucidate the molecular mechanisms of recognition and understand structure-function relationships. The successful candidate will spearhead all aspects of his/her projects including antibody engineering, protein purification, biophysical characterization, and structure determination. Our department has state-of-the-art crystallography and cryo-EM facilities along with directed evolution platforms for protein engineering. This is a unique postdoc opportunity to pursue cutting-edge technology development and publication-oriented basic research in a highly collaborative, industrial setting.
Who you are:
The successful candidate will be a highly motivated and detail-oriented researcher, driven to solve complex scientific problems, and able to work both independently and in a collaborative environment. Strong oral and written communication skills are required. Candidates must have a PhD. in structural biology, biochemistry, molecular biology, or a related field. Expertise in protein purification, biophysical characterization, and structure determination by X-ray crystallography and/or single-particle cryo-EM is required, as evidenced by a strong record of first-author publications in top peer-reviewed journals. Experience in protein engineering and directed evolution techniques, such as phage display, along with biophysical characterization methods for protein-protein interactions, such as surface-plasmon resonance (SPR) or bio-layer interferometry (BLI), are a plus.
More information on the Matsumoto Lab:
More information about the Genentech Postdoctoral Program:
Kumar N. et al. (2020) Structure of the Secretory Immunoglobulin A Core. Science 367(6481):1008-1014. DOI: 10.1126/science.aaz5807
Kumar N. et al. (2020) Structure of the Human Secretory Immunoglobulin M Core. bioRxiv DOI: 10.1101/2020.09.10.291138
Lombana T.N. et al. (2019) Production, Characterization, and in vivo Half-Life Extension of Polymeric IgA Molecules in Mice. MAbs 11(6):1122-1138. DOI: 10.1080/19420862.2019.1622940
Yau R.G. et al. (2017) Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Cell 171(4):918-933.e20. DOI: 10.1016/j.cell.2017.09.040
|10/26/20||Postdoctoral Research Fellow - Physiological Chemistry, Dixit Lab||Individual contributor||South San Francisco, California|
Seeking an independent researcher for a Postdoctoral training position in the Dixit lab to study the biochemical basis of innate immunity.
Candidate should possess a doctoral degree and have a strong background in either biochemistry, structural biology or molecular immunology. Qualified candidates must have at least one first author paper published or accepted in a peer-reviewed journal.
More information about the Genentech Postdoctoral Program:
More information about the Dixit Lab:
|10/26/20||Ophthalmology Clinical Research Fellow||Entry Level||South San Francisco, California|
Location: South San Francisco
Start Date: Fall 2020
Term: 1 year
Hours: 40 hours/week
Genentech’s Clinical Development organization is structured by therapeutic area and is responsible for developing and executing the late development (Phase Ib – III) clinical strategies and plans that deliver medically-differentiated therapies that provide meaningful improvement to patients.
Delivering superior clinical research requires close collaboration between academic and industry professionals. The Genentech Clinical Research Fellowship program entails a collaboration between academic institutions and Roche-Genentech, offering experienced MD fellows interested in a career in clinical research, a one-year experience in this area.
Roche, a world leader in clinical research, has generated large clinical databases from multiple randomized clinical trials and registries. Your own exceptional talents can help take us further, building on this data while giving you the opportunities you're seeking to propel your career.
Diverse candidates are encouraged to apply.
These would mainly consist of, but are not limited to:
Clinical Development Team - Ophthalmology
Clinical Fellowship Project
Education and Training
Candidates for this position should hold the following qualifications, have the following experience, and be able to demonstrate the following abilities to be considered as a suitable applicant. Please note that except where specified as “preferred,” or as a “plus,” all points listed below are considered minimum requirements.
QUALIFICATIONS & EXPERIENCE:
|10/26/20||Safety Director||Individual contributor||South San Francisco, California|
Portfolio Safety Scientists (PCS-Sci) provide safety science and pharmacovigilance support to molecules across the Roche portfolio. As a group, they are responsible for all aspects of safety science/pharmacovigilance, with accountability being held by PCS leadership or SSLs (Safety Strategy Program Leaders) depending on the deliverable/activity.
The Portfolio Safety Scientists (PCS-Sci) supports early and late phase development activities as a member of the safety team, providing essential safety oversight and input into all aspects of study management across the entire development and marketed portfolio. In the post-market setting this may include signal evaluation, safety related activities associated with new drug applications/regulatory filings, benefit-risk assessment and safety risk management.
A PCS-Scientist (level 4) is recognized to have strong expertise in drug safety and will be expected to work with minimal oversight and apply strong self-leadership. They will bring safety expertise to interactions with internal stakeholders, Regulatory Authorities and Data Monitoring Committees and must have the ability to interact effectively in a multifunctional and multicultural team setting. The job holder will be expected to identify areas of development and complete the required training.
They may be assigned the role of “Safety Program Strategy Leader (SSL)” for one or more molecules. The SSL is the lead safety accountable for the molecule safety strategy.
Under the matrix leadership of the SSL and/or in collaboration with PCS colleagues
● Develop and maintain an expert understanding of the safety profile of the assigned product(s) as well as understanding of the relevant strategic context (e.g., disease under study, safety profile of competitors, mechanism of action)
● Responsible for signal detection and management activities including, but not limited to STAR maintenance, ISMP maintenance.Contribute to the review of safety assessments and drug safety reports for signals or issues (inc, product quality) or in response to Regulatory Authority requests
● Provide expert contribution to the development of the product safety strategy
● Take independent responsibility for risk management activities including preparation and maintenance of CCDS, labeling document maintenance (including IB), risk communications, RMP, REMS
● Review of clinical protocols, study reports, Investigator's Brochure (IB), informed consent form (ICF) and other related documents to ensure alignment with the safety strategy and ensure the appropriateness of risk management strategies and risk communication
● Take responsibility for safety science contributions to regulatory authority submissions (Investigational New Drug/IND applications, New Drug Applications/NDAs, Marketing Authorization Applications/MAAs, Variations, Renewals, etc.)
● Responsible for the preparation and maintenance of safety sections of the Company Core Data Sheet and/or Reference Safety Information in the IB
● Participate in and provide input for Drug Monitoring Committees (iDMC) or internal monitoring committee (IMC) meetings, as applicable
● In partnership with the SSL, support presentation of important safety issues to the Drug Safety Committee (DSC), Development Review Committee (DRC) and other internal and external review and governance committees as needed.
● May be expected to support non-molecule projects, due diligence evaluations and other projects as needed.
● Perform specialized roles with PCS. These may include, but are not limited to; functional business process owner, subject matter expert, safety committee member.
● Responsible for coordination and collaboration with vendors servicing Safety Science
Additional responsibilities, under the delegated accountability of the SSL:
● Contribute and/or lead the development of the safety components of the Target Product Profile (TPP), key claims and other lifecycle strategic planning documents (e.g., IDCP, CDP)
● Accountable for the safety components of study reports, aggregate reports and high level regulatory documents
● Acquire and contribute knowledge of relevant drug class and/or competitor safety issues. Lead development of the safety surveillance strategy, identify potential clinical safety issues and recommend appropriate safety monitoring measures
● Lead the development of scientific publications (abstracts, posters, papers) for scientific meetings/journals and approve the submissions from a safety perspective
● Enable/facilitate the transition of appropriate drug candidates from EMS to LMMS Behaviors and responsibilities
● Demonstrates behaviors consistent with Roche values and engenders confidence from senior management
● Actively emulate and role model the Roche values, culture (mindset and behavior), Roche core competencies and PD/PDS strategy and drive for similar performance across relevant team
● Understands how safety activities contribute to company development and commercialization goals and takes measures to maximize safety value to the organization
● Demonstrates independence and high competence in the conduct of all safety science responsibilities
● Establish and maintain collaborative working relationships with all key stakeholders, and internal and external customers and ensure the same across relevant teams
● Consistently comply with all governing laws, regulations, QMS, Roche standard operating procedures (SOPs) and other guidelines
● Develop and maintain knowledge of the pharmaceutical industry and drug development, including a comprehensive knowledge of pharmacovigilance activities and requirements
● Acts independently and with minimal supervision to manage safety responsibilities on study teams and in activities supporting safety science
● Trains and mentors more junior PCS scientists
● Proactively takes on responsibility for complex deliverables
● Takes on team leadership responsibility in order to manage and complete medium and high priority projects
● Seen by peers and cross-functional colleagues as an expert in many safety science activities
● Contributes to embedding the agreed organizational models, and the necessary mindsets
● Leading self and others, often influencing without authority, to deliver outcomes.
● Brings critical, systematic thinking to shape current issues and opportunities into meaningful, deliverable actions.
● Willing to challenge embedded behaviors/mindsets, in order to bring new and agile approaches to ways of working, and/or to improve quality and efficiency.
● Holds themselves and peers accountable for their behaviors and actions
Education, Skills and Experience:
Minimum Qualifications: Qualified healthcare professional or Life Sciences graduate.
Preferred Qualifications: A relevant postgraduate qualification (e.g. PHD/MSc in a Life sciences discipline; PharmD or other post-graduate health professional qualifications) would be advantageous
● Safety Director: 6 or more years of drug development experience in the pharmaceutical or related industry including at least 3 years in drug safety
● The ability to demonstrate a broad understanding of the scientific aspects of safety, PV and clinical/patient risk management (e.g. via demonstrable knowledge of the application of GVP, GCP & CTR requirements) is essential.
● Demonstrated ability to lead and influence, with and without authority, in a global matrix environment.
● Excellent written and verbal communication skills.
● Proven success in creating and sustaining strong relationships with internal and external business partners across an organization to create positive partnerships.
● Evidence of proactive, structured thinking with the ability to rapidly respond to an evolving and complex environment.
● Apply complex data analysis / statistical methods to evaluate, interpret and present scientific data with clarity
● Strong presentation skills, effective at summarizing and presenting the key considerations and decision points
● Ability to effectively train others on departmental practices and processes
● (For roles in China) Fluent in Mandarin and English
|10/26/20||Senior Principal Medical Director-Multiple Sclerosis||Individual contributor||South San Francisco, California|
Title: Senior Principal Medical Director, Multiple Sclerosis
Organization: US Medical Affairs
Location: South San Francisco, CA
The Senior Principal Medical Director at Genentech puts patients and science at the center of all actions. They drive medical tactics aimed at maximizing medical progress for patients. They collaborate to drive timely data generation and dissemination. They are expected to maintain an in-depth understanding of the medical strategy and relevant clinical and payer issues, while ensuring Genentech's partners understand key trends and shifts in the external healthcare landscape. They serve as the guardian for high standards of compliance, ethics and safety. This position sits within a network of clinical and scientific experts, and therefore may be performing a variety of medical activities, as needed.
We are seeking a dynamic medical leader to focus in the area of Multiple Sclerosis (MS) to join the US Medical Affairs network of scientists at Genentech. The Senior Principal/Principal Medical Director will provide exceptional clinical and scientific leadership for medical affairs activities in the area of MS and related disorders. With an aim of generating and communicating medical evidence that helps practitioners, patients and payers make good health care decisions, the successful candidate exhibits outstanding communication and leadership skills and builds strong relationships with key stakeholders in the MS community.
This individual will be responsible for the execution of medical activities within the context of the US health care environment that, depending on specific areas of responsibility, may include clinical study design and monitoring; clinical and health economic data analysis, interpretation and publications; medical content development and review; clinical training and insights generation; and scientific exchange and collaboration.
This position will also represent the US Medical function within cross functional teams and initiatives at Genentech, within the Roche global organization, and in external customer facing engagements. In addition to strong communication skills, this position requires the ability to lead fit-for-purpose teams in a matrix environment, flexibility in prioritizing work, and a mindset to engage in purposeful partnerships to solve complex multi-disciplinary challenges.
As a Senior Principal Medical Director you are expected to:
Who you are
A leader with a strong scientific and clinical background who has a passion for making medical progress for people affected by MS. You are looking for a company where you have the opportunity to positively impact peoples’ health, and where a job title does not define who you are professionally but is the starting point of what you can achieve.
Qualifications, Experience and Skills
CMG Operating Principles
I put the patient first, always
I build our reputation
External Link: https://www.gene.com/careers/commercial-operating-principles
Roche is an equal opportunity employer.
|10/26/20||Senior Scientific Researcher, Human Genetics||Individual contributor||South San Francisco, California|
The Cancer Immunology Department is seeking a highly motivated Senior Scientific Researcher to perform discovery research at the interface of human genetics, immunology and cancer. The successful candidate will lead research projects to implement and apply statistical genetics methods and integrate additional data modalities such as RNA-seq or tumor genomes to identify and enhance our understanding of novel therapeutic targets and biomarkers, and will be expected to make intellectual as well as technical contributions to the team.
Genentech provides an exceptional research environment composed of internationally recognized leaders as well as state of the art core facilities with cutting edge technologies and computational resources to support all research activities. You will have the opportunity to participate in the discovery and investigation of drug targets, and contribute to a better understanding of individual differences in patients’ responses to cancer immunotherapy. We provide a highly collaborative community, and you will work closely with other researchers in the areas of Cancer Immunology, Human Genetics, Bioinformatics and Statistics.
The successful applicant will have a PhD in human or statistical genetics or a related field and experience in an academic or industry setting. Candidates must have a documented record of professional achievement in the form of impactful publications, and must be familiar with statistical association (e.g. Plink, SAIGE) and fine-mapping approaches (“variant-to-function”). Expertise in the use of a high-level programming language such as R (preferred) or Python for statistics and computational biology is required, as well as familiarity with UNIX and high-performance computing environments. Experience in differential expression analyses is a plus. Excellent oral/written communication skills, creative problem-solving flexibility, and the ability to integrate detailed analyses into a larger disease-oriented context will be expected.
|10/26/20||Sr. Finance Director||Executive (Director/VP)||South San Francisco, California|
Genentech CMG Finance is excited to hire a Senior Director to lead the OMNI Finance team and provide ecosystem support for the Mid-Atlantic (Ecosystem) Region.
|10/23/20||EHS Strategy & Business Operations, Site Services||Manager with direct reports||South San Francisco, California|
Main Purpose of the Position:
The Environment, Health and Safety (EHS) Strategy & Business Operations leader will head several business critical areas that are core to the effective performance of the EHS department, including:
This critical position reports directly to the Senior Director of EHS and serves as a member of the EHS leadership team. Directly reporting to this position will be a small team.
This leadership position will be accountable for partnering with the Senior Director of EHS and EHS leadership team to develop, align and implement EHS multi-year strategies and goals that reflect EHS’ role as steward for the Genentech culture. This position will also be pivotal in ensuring EHS creates and realizes an operating model that makes the customer experience easier and increases the influence and impact of EHS as a strategic partner to the business in their risk decisions and in creating a safety culture throughout Genentech.
This role will be a member of the Site Services Business Manager Forum and will work closely with the Site Services Director of Strategy and Business Operations as well as other Site Services leaders in functions responsible for protecting our right to operate and ensuring business continuity.
This individual will also need to build strong relationships with internal Roche functions and external regulatory agencies, including those who do audits of Genentech’s business.
The ideal candidate will be a passionate advocate for a safe, healthy and sustainable work environment and bring strategic consulting experience in leading change in complex, highly regulated businesses that are shifting to more agile ways of working.
Competencies Identified for Success:
Qualifications: Education, Experience, Knowledge and Skills:
|10/23/20||Bioinformatics Scientist, Cancer Immunology||Individual contributor||South San Francisco, California|
Genentech seeks a talented and highly motivated computational biologist/bioinformatics scientist to pursue reverse translational data-driven projects in close collaboration with our Oncology Biomarker Development and Cancer Immunology Departments.
Recently, exciting developments at Genentech and elsewhere have demonstrated the potential of leveraging the human immune system for effective and durable control of cancer. Our extensive high-dimensional molecular characterization of samples from cancer immunotherapy clinical trials provide an outstanding opportunity for rapidly taking clinical insights back into the laboratory.
The primary focus of this position is on deep exploration of high dimensional clinical trial datasets, with the goal of translating findings into testable hypotheses about the variability in human immunotherapy response. This high-impact work informs new investigational immune-based cancer therapies and combinations.
Applicants should be able to work comfortably on an interdisciplinary team, have a strong desire to carry out data analysis and integration across various domains (High-throughput Transcriptomic, Genomic, Proteomic, Epigenomic data), and apply best-in-class algorithms — or develop new algorithms — that directly address the motivating biological and clinical questions. Regular publication of scientific results is strongly encouraged. Finally, applicants should be able to effectively present complex results in a clear and concise manner that is accessible to a diverse audience of quantitative, experimental, and clinical scientists.
Who you are
What to expect from us
|10/23/20||Computational Biology Scientist, Cancer Immunology||Individual contributor||South San Francisco, California|
Genentech seeks a talented and highly motivated computational biology / Bioinformatics scientist to pursue reverse translational data-driven projects in close collaboration with our Cancer Immunology and Oncology Biomarker Development Departments.
Recently, exciting developments at Genentech and elsewhere have demonstrated the potential of leveraging the human immune system for effective and durable control of cancer. Our extensive bulk and single-cell RNA-seq characterization of samples from cancer immunotherapy clinical trials provide an outstanding opportunity for rapidly taking clinical insights back into the laboratory.
The primary focus of this position is the identification of signals in single-cell and bulk RNA-seq data that are associated with the variability in human immunotherapy treatment response. This will form the basis to further investigate the mechanistic basis for the clinical observations.
Applicants should be able to work comfortably on an interdisciplinary team, have a strong desire to carry out data analysis and integration across various domains (High-throughput Transcriptomic, Proteomic, Epigenomic data), and apply best-in-class algorithms — or develop new algorithms — that directly address the motivating biological and clinical questions. Regular publication of scientific results is strongly encouraged. Finally, applicants should be able to effectively present complex results in a clear and concise manner that is accessible to a diverse audience of quantitative, experimental, and clinical scientists.
Who you are
What to expect from us
|10/23/20||Global Head Sustainability, Risk & Compliance||Manager with direct reports||Basel, Basel-City|
At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity, and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves.
That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
The Basel Branch Roche Diagnostics International, Diabetes Care employs over 100 people and is the headquarter of the business unit Diabetes Care. As a world-leading supplier of system solutions for patients with Diabetes, the products provide health information to medical decision-makers pivotal for early identification, diagnosis & monitoring.
You will report directly to the RDC Head Global Procurement, be part of the RDC Global Procurement Leadership team, and hold global responsibility within RDC Global Procurement for the 3 areas of:
Sustainability: Setting the strategy and direction for the Sustainability agenda within RDC Global Procurement across our area of responsibility within Direct and Indirect categories and the associated supplier landscape. Develop a Sustainability program with clear initiatives for the next 5 years. Risk: Develop the risk management approach for the supplier landscape within RDC maximizing already existing business continuity plans and processes. Single Point of Contact from Global Procurement for supply risk assessment of suppliers as well as developing the risk mitigation plans in close collaboration with relevant business partners. Compliance: On an ongoing basis securing compliance to Roche Group and Roche Diabetes Care quality management systems as well as global and local SOP’s, guidelines etc. Maintain global overview of upcoming audits as well as securing involvement of right business process manager within RDC Global Procurement when deemed necessary for specific audit preparations and audit execution. Focus on securing continuous improvements in our global procurement process landscape as well as supporting business processes to increase audit readiness.
If you are proud of contributing and feel you have the dedication to teamwork and innovation that we are seeking, then Roche is the organization for you. Every role at Roche plays a part in making a difference in patients’ lives. If you want to work in a passionate team, make your mark & improve lives, apply now.
Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
|10/23/20||Principal/Senior Medical Director or Medical Science Director-NMO/MS||Individual contributor||South San Francisco, California|
Title: Principal/Senior Medical Director or Medical Science Director, NMO/MS
Function: US Medical Affairs
Location: South San Francisco, CA
"Before posting, we considered the business, team, and customer needs for this role in light of our efforts to post and fill only those roles that are absolutely critical"
The Principal/Senior Medical Director or Medical Science Director at Genentech puts patients and science at the center of all actions. They drive medical tactics aimed at maximizing medical progress for patients. They collaborate to drive timely data generation and dissemination. They are expected to maintain an in-depth understanding of the medical strategy and relevant clinical and payer issues, while ensuring Genentech's partners understand key trends and shifts in the external healthcare landscape. They serve as the guardian for high standards of compliance, ethics and safety. This position sits within a network of clinical and scientific experts, and therefore may be performing a variety of medical activities, as needed.
We are seeking a dynamic medical leader to focus in the area of neuromyelitis optica (NMO) with the potential of additional activities supporting our multiple sclerosis (MS) program. This lead will join the US Medical Affairs network of scientists at Genentech. The Principal/Senior Medical Director or Medical Science Director will provide exceptional clinical and scientific leadership for medical affairs activities in the area of NMO/MS and related disorders. With an aim of generating and communicating medical evidence that helps practitioners, patients and payers make good health care decisions, the successful candidate exhibits outstanding communication and leadership skills and builds strong relationships with key stakeholders in the NMO/MS community.
This individual will be responsible for the execution of medical activities within the context of the US health care environment that, depending on specific areas of responsibility, may include clinical study design and monitoring; clinical and health economic data analysis, interpretation and publications; medical content development and review; clinical training and insights generation; and a focus on scientific exchange and collaboration.
This position will also serve as a leader to the US Medical function within cross functional teams and initiatives at Genentech, within the Roche global organization, and will lead and participate in external customer facing engagements. In addition to strong communication skills, this position requires the ability to lead fit-for-purpose teams in a matrix environment, flexibility in prioritizing work, and a mindset to engage in purposeful partnerships to solve complex multi-disciplinary challenges.
As a Principal/Senior Medical Director or Principal/ Senior Medical Science Director you are expected to:
Who you are
A leader with a strong scientific and clinical background who has a passion for making medical progress for people affected by NMO and MS. You are looking for a company where you have the opportunity to positively impact peoples’ health, and where a job title does not define who you are professionally but is the starting point of what you can achieve.
Qualifications, Experience and Skills
CMG Operating Principles
I put the patient first, always
I build our reputation
External Link: https://www.gene.com/careers/commercial-operating-principles
Roche is an equal opportunity employer.
|10/23/20||Senior Data Center Manager||Individual contributor||Hillsboro, Oregon|
Provide technical leadership to an onsite team of employees in aligning goals and ensuring targets are met. Ensure efficient and effective delivery of operational plans based on agreed IT processes, standards and tools.
Communication – communicates functional vision/roadmap and departmental goals and work to assure employee buy- in and acceptance.
Data Centers Americas provided power, rack space, cooling, and physical network cabling to Genentech’s IT Infrastructure in Hillsboro and other sites. The role of Data Center Manager is to provide technical ability to all onsite data centers to complete support and work requests (Allocate/install rack space, hardware installs, network cross connects and hand off’s, rack power installation, out of band console support, remote smart hands/eyes, access & environmental support), ensuring efficient and effective delivery of operational plans based on agreed IT processes, standards and tools. This role will work in conjunction with the rest of the Compute, Storage, and Cloud Services team to ensure hosted systems deliver the expected uptime and performance requirements to our global user base.
Data Analytics – Use Data Analytics best practices to review Incident Management, Data Center Information Management (DCIM) and Managed Services data to discover trends and opportunities for service improvement.
DCIM Administration – Function as an expert user in use of and implementation of DCIM tools. Accountable for proper functioning and upgradeability of the tool.
Operational Support – Responsible for the day to day operations and maintenance of data center infrastructure. Responsible for driving the completion of service requests, incident, and problem tickets. Supports an environment of teamwork within our area and across the wider IT area. Brings concerns to the Data Centers Americas Team Lead. Drives efficiency by utilizing globally defined best practice processes for IT operations. Follows defined working processes and standards in the execution of daily duties and job functions. Understands and follows local Finance rules to support a balanced budget for the local site. Reviews trends of IT and data center infrastructure equipment, evaluates impact and potential requirements for data centers. Ensures that Data Center capacities are used in the most economical and ecological way.
DC Strategy – supports the definition and implementation of Data Center strategies and plans. Supports projects related to data centers, data center consolidation and operations.
Data Center Security and Safety – ensures that Data Centers are operated in a controlled manner based on clearly defined, agreed and monitored security and safety standards.
Data Center Facilities and Infrastructure Management – supports Data Center facilities and infrastructure by considering all relevant capacity, security, safety, environmental and financial aspects to ensure they are operated in an economical and ecological way.
Manual Operational Support for IT Infrastructure – actively supports the reduction of manual interventions on IT infrastructure by analyzing current situations and documenting impact. Challenges relevant organizations and projects to eliminate technologies which require frequent manual intervention. Plans and performs manual interventions on IT infrastructure as defined and agreed.
Change Management – coordinates and schedules change requirements between IT, facilities and business requirements. Proactively assesses impact on data center and proactively discusses IT infrastructure plans/projects which might influence DC space and energy consumption with all relevant parties.
Quality – ensure permanent inspection readiness of Data Centers. Responsible for maintaining and continuously improving the quality system and achieving quality objectives through daily actions.
KNOWLEDGE/ SKILLS/ATTRIBUTES: The minimum education, knowledge, experience, skills and attributes required to perform the essential functions of this position.
|10/22/20||Alliance and Partnerships Leader / Sr. Alliance and Partnerships Leader||Individual contributor||South San Francisco, California|
The Alliance and Partnerships Leader is responsible for managing strategic relationships with key clinical research sites and other external clinical trial access points that support early phase clinical trials. Leveraging strong alliance management capabilities, the role develops and delivers effective relationship strategies in collaboration with internal and external stakeholders. The scope of the role includes the following:
The Sr. Alliance and Partnerships Leader leverages advanced knowledge of the drug development process, advanced relationship management skills, and strong understanding of current and future industry trends to develop, drive and lead these activities.
The right candidate for this role will possess the following qualifications:
A flexible work arrangement and remote work from a US-based location will be considered.
|10/22/20||Bioinformatics Scientist/Senior Scientist, Discovery Oncology||Individual contributor||South San Francisco, California|
Genentech seeks a talented and highly motivated candidate for a computational biology position in discovery oncology research. We are looking for a computational scientist who is excited about collaborating with world-class scientists with diverse backgrounds to move science and drug development forward with the goal of making a true difference for patients.
The Discovery oncology group is focused on developing therapies targeting major pathways involved in cancer. Our research efforts are rooted in a deep understanding of cancer genomics spanning patient data (i.e. TCGA and other data sources), internal clinical data to pre-clinical models of cancer (i.e. PDX, GEMMs, tumor cell lines). Through experimental and computational approaches, our goal is to understand the mechanistic basis of therapeutic response and resistance as well as to discover novel targets/pathways in tumors. Additionally, we are actively looking for biomarkers that can help match our drugs to the patients that would benefit most from treatment. In our research we apply a wide variety of high-throughput data technologies and utilize many big genomic data sets from both internal and public sources to guide our studies.
Therefore, we are looking for a candidate who is exceptionally competent with computational tools and their application to a diverse set of large-scale data but also has the biological knowledge to be able to ask the right questions and place the results in the appropriate context to effectively move research forward.
A successful candidate will act as the bioinformatics lead on interdisciplinary teams that contribute to drug development. She/he will lead a research agenda involving the design of experiments, analysis of a wide variety of high-dimensional data and integration of results with current biological knowledge. Further, the successful candidate should be able to effectively present complex results in a clear and concise manner — to other computational scientists as well as to audiences with other scientific backgrounds. Regular publication of scientific and methodological results is highly encouraged.
|10/22/20||Bioinformatics Scientist/Senior Scientist, Immunology, ARDS and COVID||Individual contributor||South San Francisco, California|
The Genentech Bioinformatics department seeks a highly motivated Reverse Translation Scientist/Senior Scientist to leverage computational biology to study the molecular pathways that contribute to acute respiratory distress syndrome (ARDS), including those associated with COVID-19. The successful candidate will work with colleagues in the Translational Genomics and Immunology departments to pursue the development of novel therapeutics and biomarkers related to ARDS. The successful candidate will work as a member of a highly collaborative team to design experiments, interpret data, and develop computational solutions to address underlying biological questions. The successful candidate will lead a computationally-driven research program focused on leveraging high-dimensional data from patient-derived tissue and biofluids to develop a better understanding of the molecular mechanisms driving ARDS.
|10/22/20||Bioinformatics Scientist, Immunology||Individual contributor||South San Francisco, California|
The Immunology Bioinformatics group is seeking a highly motivated computational Scientist to engage in therapeutic and biomarker discovery efforts within our airway disease and fibrosis programs. The successful applicant will collaborate with an interdisciplinary team of research scientists to understand the molecular mechanisms involved in diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and cirrhosis. The ability to collaborate with a diverse group of scientists, drive an independent research program, and publish scientific/methodological papers on a regular basis are important components of this position.
|10/22/20||Bioinformatics Scientist, Translational Genomics||Individual contributor||South San Francisco, California|
Genentech seeks a motivated Bioinformatics scientist or Computational Biologist to collaborate in the development of novel therapeutics and biomarkers to be used in cellular reprogramming and regeneration, for the treatment of immunological and ocular diseases such as inflammatory bowel disease, age-related macular degeneration, and idiopathic pulmonary fibrosis. The successful candidate will work in a collaborative environment, teaming with discovery scientists to design experiments, analyze results, and prototype bioinformatics solutions to answer underlying biological questions.
Who you are:
As a scientist you will:
|10/22/20||Bioinformatics Scientist, Neuroscience Reverse Translation||Individual contributor||South San Francisco, California|
The Genentech Bioinformatics department seeks a highly motivated Reverse Translation Scientist to study the molecular pathways that contribute to neurological diseases including Alzheimer’s Disease and Multiple Sclerosis. Applicant will work with colleagues in Translational Genomics and Neuroscience departments to pursue novel therapeutics and biomarkers for disease areas of focus in the Neuroscience department. The applicant will lead a data-driven research program generating and leveraging high-dimensional ‘omic data from both in vitro human cell models and patient-derived tissue and biofluids.
|10/22/20||Senior Bioinformatics Scientist, Neuroscience Reverse Translation||Individual contributor||South San Francisco, California|
The Genentech Bioinformatics department seeks a highly motivated Reverse Translation Senior Scientist to study the molecular pathways that contribute to neurological diseases including Alzheimer’s Disease and Multiple Sclerosis. The applicant will work with colleagues in Translational Genomics and Neuroscience departments to pursue novel therapeutics and biomarkers for disease areas of focus in the Neuroscience department. The applicant will lead a data-driven research program generating and leveraging high-dimensional ‘omic data from both in vitro human cell models and patient-derived tissue and biofluids.
These are our stories - stories of the obstacles and opportunities that define and celebrate the unique people at Genentech.