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Date Job Title Job Level Location
4/16/21 Chief of Staff for SVP and Head of Development Sciences Manager with direct reports South San Francisco, California

Strategic Partner

  • Be a thought-partner and trusted advisor to the SVP of DevSci on business, organizational, and operational strategies and solutions

  • Organize and prioritize critical issues and required information for the SVP of DevSci to facilitate efficient decision making

  • Partner with the SVP of DevSci and DSLT in strategic planning, policy development and decision-making

  • Partner with the DevSci Communications manager to shape messaging and implement communications for the DevSci organization on behalf of the SVP of DevSci and DSLT

  • Serve as a spokesperson and advocate for the SVP of DevSci and their leadership team for both internal and external stakeholders

  • Drive and execute complex and cross functional initiatives in a timely manner on behalf of the SVP of DevSci

DevSci Leadership Team (DSLT) Management

  • Act as the liaison between the SVP of DevSci and DSLT members to ensure consistent communication, involvement and decision-making at the proper time

  • Manage DSLT meetings, including preparing agendas, ensuring materials are sent in advance, time is well spent and objectives are achieved. Provide guidance on meeting agendas for broader leadership meetings led by the SVP of DevSci.

  • Maintain accurate confidential files and data records

  • Lead the planning of DSLT offsites and events

The Chief of Staff partners closely with other business managers in the organization to drive cross-functional initiatives and may mentor or manage staff.

Successful factors for the Chief of Staff role include the ability to:

  • Build and maintain strong relationships with the SVP of DevSci, their leadership team, and others in the organization in order to advise and influence outcomes

  • Assist and communicate with executives in decision-making, program management, and initiative implementation

  • Understand the strategic, big picture priorities while managing the detailed execution of deliverables

  • Navigate ambiguous situations to unearth and address core issues or challenges

  • Independently lead and drive cross-functional initiatives, projects or programs

  • Develop new approaches to address complex organizational challenges that impact DevSci and beyond

  • Facilitate resolution of issues relating to projects, priorities and team dynamics

  • Demonstrate creativity, independence, and initiative in resolving issues

Qualifications 

Requirements:

  • MS/PhD in a Scientific discipline or relevant scientific subject

  • 12+ years experience in applying and communicating project management principles and processes

  • Prior experience working in a scientific/technical environment, preferably biotech

  • Excellent communication skills, both written and oral

  • Able to effectively partner with executive leaders in scientific/technical organizations

  • Able to build and maintain strong working relationships

  • Strong record of managing multiple stakeholders, and a desire to deliver service excellence

  • Positive outlook

  • High degree of flexibility, adapting to the organization’s priorities

  • Strong analytical, critical thinking, and problem solving skills

  • Strong organizational skills with attention to detail

  • Ability to effectively function with limited direction

  • Results oriented yet with a tolerance for ambiguity and change

  • Able to prioritize team activities and influence strategy

  • Advanced competence in the use of software programs (Google Suite)

  • Ability to work effectively on multiple projects simultaneously

  • Knowledge of Genentech or Roche culture, systems and organization is a plus

4/16/21 Senior Scientific Researcher, PET Radiochemistry Individual contributor South San Francisco, California

The Biomedical Imaging Department at Genentech invites applications for a full-time Senior Scientific Researcher in PET radiochemistry. The Biomedical Imaging Department is a dedicated, state-of-the-art research facility that includes pre-clinical Micro-PET/CT, MRI, Micro-CT, ultrasound, as well as optical imaging techniques. The PET radiochemistry laboratory develops and supplies PET tracers labeled with 18F, 68Ga, 89Zr and 124I for use in pre-clinical imaging at the facility to support research activities at Genentech. The radiochemistry facility is equipped with full size hotcells, minicells, automatic synthesizer, and analytical instrumentation. The position will focus on design, development and application of radiolabeling techniques for small and large molecules. The ideal candidate will have a strong background in synthetic organic chemistry and radiochemistry, chemical and radiochemical analytical methods, and a keen interest in applying in-vivo imaging to address specific biological questions related to our research programs.

Responsibilities

  • Development of radiolabeling techniques for small molecules and biologics
  • Design and synthesis of precursors for radiolabeling
  • Characterization of radiolabeled tracers
  • Formulation of tracers for in-vivo imaging

Requirements

  • Ph.D. or equivalent industrial experience in organic chemistry or radiochemistry. Postdoctoral training is preferred.
  • Excellence in the field as evidenced by peer-reviewed publications.
  • Strong experience with synthetic organic chemistry and radiochemistry, chemical and radiochemical analytical methods
  • Strong communication and collaboration skills.

Preferred Experience and Competencies

  • Knowledge of bioconjugation techniques for radiolabeling peptides, proteins and biopolymers
  • Experience with quality control and manufacturing of radiopharmaceuticals for clinical use
  • Experience with radiochemistry process automation

Join a Team that Lives to Improve Lives

People come to Genentech from across disciplines and across the world to solve our most

challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

A Job with Benefits Beyond the Benefits

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page https://www.gene.com/careers.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

#LI-JD1

4/16/21 Clinical Program Director Individual contributor South San Francisco, California

The Position Purpose:

The Genentech Research and Early Development (gRED) Clinical Program Director is a key strategic leadership role accountable for evaluation of strategic options, development and delivery for assigned early development programs.  The Clinical Program Director helps define and implement vision and strategy for study management and is accountable for functional management including recruiting, building and maintaining a high quality gRED Clinical Operations.

Primary Accountabilities and Responsibilities:

Program Management Responsibilities:

Through appropriate leadership, direction and operational expertise, lead the development and execution of global operational strategies for multiple molecules/programs in Genentech’s early development portfolio:

  • Recognized as expert thought partner in drug development with thorough understanding of all aspects of clinical drug development

  • Core member and Clinical Operations representative on the Early Development Teams (i.e. Core, Development or Clinical Sub-Teams) serving as a primary consultant to senior-level colleagues, functional leadership and cross-functional stakeholders within and outside of gRED

  • Makes broad contributions to the development of the clinical development plan (CDP) and establishes the operational strategy for new programs

  • Partners with late stage to ensure strategic alignment of CDP, country/site strategies, and planning of end-to-end lifecycle of molecule

  • Provides program leadership to global cross-functional teams across the Roche group (e.g. Affiliates, MSLs, etc) including external partners and vendors through oversight, guidance, strategies and direction to achieve results; 30-50% of time spent leading and managing through people

  • Provides innovative and flexible operational solutions and ability to understand, critically assess and influence global clinical development plans, protocol design, resource needs, global budgets and timelines for programs

  • Provides disease area expertise and input to the function and the TA while anticipating changes in the disease landscape (e.g. standards of care) and regulations that impact operational strategies

  • Accountable for meeting all operational deliverables in accordance with time, cost and quality commitments. Maintains an overview of status, risks, and proactively communicates progress, issues or changes that may impact timelines and costs of the program to all stakeholders including the Therapeutic Area leadership. Maintains internal consistency across studies within a program

  • Leverages internal resources pan-Roche to identify potential novel partnership opportunities to accelerate development of clinical programs while leveraging solutions, lessons learned and sharing knowledge broadly

  • Participates in Business Development/in-licensing assessments as requested, providing strategic input as well as operational elements in terms of costs, resources, and timelines

  • Leads gRED Clinical Operations Disease Teams and development of operational strategies across gRED molecules.  Provides disease area input and member of global disease teams in partnership with PD, pRED and gRED

Functional Management Responsibilities:

Provide leadership, guidance, and manage the performance and development of 5-6 direct reports; administer performance programs in accordance with policies, and ensure the development of potential succession candidates.  Additionally, the Clinical Program Director will contribute to the Clinical Operations organization. These responsibilities include:

  • Identify, recruit, and hire Clinical Operations Study Management staff, as well as oversee their work to ensure all department goals, deliverables and objectives are met

  • Identify and manage resource needs through proactive planning and effective recruitment

  • Ensure that employees are appropriately trained, developed and coached to comply with company policies and Global regulations

  • Participate in and/or lead working groups and/or business improvement efforts within the gRED organization to improve clinical trial processes, systems, methodologies, and tools

  • Participate in enterprise wide initiatives (as needed) to support and influence the future direction of the organization

  • Partner with ECD Business Operations team to develop role-based competency and training strategies and programs

  • Partner with ECD Informatics team to establish strategies and priorities in support of improving and advancing clinical trials

  • Advocate/drive/support goals and changes within the organization

  • Lead by example to create a positive work environment by encouraging mutual respect, innovation, smart risks and accountability on a functional and project level, both locally and globally, to help the organization to continuously evolve, improve and excel

Qualifications:

  • 12+ years experience of clinical and drug development (or equivalent), including 5+ years of clinical trial management experience

  • 2+ years of clinical program management experience

  • Functional management experience

  • Bachelor's Degree or equivalent required (scientific or healthcare discipline preferred). Advanced degree preferred

  • Working knowledge of international regulatory and ICH GCP guidelines

Experience, Skills, Behaviors, Knowledge:

  • Proven ability to lead teams, form productive working relationships within and external to the department, using the skills of collaboration and influence in areas of problem solving

  • Demonstrated ability to work in a volatile, uncertain, complex and ambiguous (VUCA) environment and skilled at making quick and informed decisions with limited information

  • Substantial experience in organization, implementation, and delivery of global clinical programs

  • Demonstrated ability to manage larger-scale, cross-functional strategic projects, activities and teams; effectively formulate strategies, tactics and action plans to achieve results, and continuously move the business forward

  • Uses understanding of major business functions, industry trends, and own organization's position to contribute to effective business strategies and/or tactics

  • Meaningful analytical skills, including previous experience with forecasting, analyzing and interpreting benchmarking research results. Ability to analyze complex activities and information to arrive at reasonable conclusions

  • Identifies and leverages opportunities to accelerate results and build capability by assigning tasks and decision-making responsibilities to individuals or teams with clear boundaries, expectations, support, and follow-up

  • Demonstrated ability to think globally and apply creative solutions to problems without defaulting to status quo including welcoming diversity of thought to make decisions

  • Change leader with ability to drive, encourage and support innovation

  • Ability to think beyond own department, identifying connections between different areas of the organization to positively impact the business and its customers

  • Ability to set clear vision/strategies and removes obstacles for teams that are barriers to doing productive/high impact work

  • Demonstrated leadership, influencing, and motivational skills. Communicates with energy and passion, to engage and inspire others

  • Proven ability to coach, develop, manage performance, and mentor personnel

Other (e.g. Travel):

Willingness to travel domestically and internationally, and work across cultures.

#LI-CA1

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

4/16/21 Clinical Scientist Individual contributor South San Francisco, California

The Early Clinical Development (ECD) group at Genentech is seeking a talented Clinical Scientist who is passionate about translating preclinical discoveries into the next generation of therapies, particularly in the area of ophthalmology. The role will focus on clinical and pre-clinical programs that explore the potential of a broad ophthalmology portfolio with promising and diverse new agents targeting a range of ocular conditions. The Clinical Scientist (CS) will work with Medical Directors and cross-functional teams on innovative science and development programs to bring novel therapies to patients with ocular diseases.

The CS will be integral in driving the deliverables for early clinical development programs, particularly first-in-human, Phase 1 and Phase 2 studies or observational study. The CS will contribute to clinical development strategy and clinical study design and will work closely with cross-functional teams to author study protocols, informed consent forms, investigator brochures, clinical study reports, study manuals, INDs, publications, presentations and regulatory documents. The CS will participate in the development of electronic clinical data case report forms, author medical data review plan, review data integrity and trend, and contribute to study monitoring and data analysis.

The CS will be a member of clinical sub-teams and protocol execution teams and will be expected to establish effective and collaborative relationships across the organization. The CS may serve as the clinical department’s point of contact in settings such as protocol execution teams, inquiries from study site coordinators or investigators and contract research organizations. The CS will review medical data from ongoing studies, follow-up on laboratory results and safety event documentation, and address queries, with oversight by medical monitors. The CS will support and present at advisory boards and/or investigator meetings. The CS will train internal, CRO and site staff on clinical aspects of study protocols.

All of our employees are critical to success in bringing novel medicines to patients and we are dedicated to being a great place to work.

Qualifications

We are looking for someone inspired by our mission and well suited for the collaborative, rigorous and entrepreneurial spirit of the company. Requirements include:

  • A clinical or scientific advanced degree (e.g., PhD, PharmD, MA/MS/MPH); equivalent combination of relevant education and experience may also be considered

  • 2+ years relevant pharma/biotech industry experience OR relevant equivalent clinical or laboratory research experience

  • Excellent collaborative, teamwork and organizational skills, with the ability to complete deliverables by working effectively with colleagues

  • Business acumen and excellent project management skills

  • Strong interpersonal, verbal communication and influencing skills with the ability to drive discussions and decisions toward desired end-results

  • Outstanding attention to detail

  • Experience with authoring protocols, study start-up, study conduct, data interpretation and the preparation of regulatory documents are advantages, particularly for interventional Phase 1, Phase 2, and international studies

  • Knowledge of Ophthalmology is an advantage but not required

#ophthalmology #pharmajobs

#LI-KD1

4/16/21 Postdoctoral Fellow - Antibody Engineering, Carter Lab Individual contributor South San Francisco, California

This Postdoctoral Fellow will be mentored by an experienced researcher with a track record of developing novel technologies that have led to at least ten antibody therapeutics used to treat millions of patients worldwide. The successful candidate will engineer antibodies and other proteins through rational design and molecular evolution technologies to enhance their existing properties or endow them with brand new capabilities. Major lab interests include making intractable targets for antibodies druggable - pursuit of the ‘high-hanging fruit’. Long term research goals for the lab include intracellular delivery of protein drugs and immunogenicity risk-assessment for engineered protein therapeutics.

Requirements:

  • A PhD in Molecular Biology, Protein Chemistry, Structural Biology or a related discipline.

  • One or more first author research publications in high quality journals in protein/antibody engineering or a related field.

  • Experience in protein/antibody engineering from rational design, through generation of mutants, to the expression, purification and characterization of mutant proteins is desirable.

  • Expertise with molecular evolution technologies such as yeast or phage display is a plus.

Additional Qualifications:

  • Creative individual with a passion for science and capable of independent work in a collaborative environment are particularly encouraged to apply.

  • Excellent oral and written communication skills are needed.

More information about the Carter Lab:

http://www.gene.com/scientists/our-scientists/paul-carter

More information about the Genentech Postdoctoral Program:

https://www.gene.com/careers/university-and-early-career/postdocs

#L1-SN1

#postdoc

4/16/21 Sr. or Principal Quality and Compliance Manager Individual contributor South San Francisco, California

In this fast-paced and varied position, you will serve as an important conduit to the broader organization to ensure a culture of compliance through well thought out, actionable, aligned and achievable Good Clinical Practice (GCP) related processes and procedures.  You will communicate and interface with a host of internal cross-functional partners, both within Genentech Research and Early Development (gRED) and other Roche functions, identifying areas for improvement and ensuring compliance with current regulatory policy, legislation and guidance.



Responsibilities:

  • Interacts cross functionally with Drug Safety, Quality Assurance/ Risk Management, Clinical Operations, Healthcare Law, Corporate Group & Risk Advisory, and Medical Affairs to ensure SOPs, Policies or Work Instructions are in place.

  • Collaborates with Genentech Early Clinical Development (ECD), Quality and Compliance Office (QCO) to implement and maintain the Functional Quality Management System (QMS) and its related documents, in alliance with the Quality principles outlined in the Global Roche GCP /GVP Quality Manual.

  • Provides expertise and consultative guidance on business initiatives involving systems, processes, procedures, regulations and tools intended for use in clinical trial conduct and/or regulated drug development activities.

  • Communicates controlled document and policy changes within/across the gRED organization.

  • Serves as a consultant to management and act as an internal/external spokesperson for the organization on matters pertaining to policies, quality plans, objectives and business goals.

  • Proactively researches, evaluates and makes recommendations associated with evolving laws and regulations.  Benchmarks and stays abreast of other industry and marketplace developments and best practices.

  • Effectively integrates compliance risk/context and business knowledge to address unusually complex problems. Keeps current in the area of healthcare compliance, GCP, GVP, and company policy and procedures.

  • Recommends and drafts new or amended policies & SOPs in support of regulatory policy, law and regulations while specifying actual or potential implications to existing business operations, procedures and practices.

Qualifications

The right candidate will possess the following skills and experience. The level of the position will depend on the qualifications of the selected candidate.

  • Bachelor's degree, preferably in medicine, pharmacy or other healthcare discipline.

  • 10+ years of relevant experience in pharmaceutical drug development, preferably in regulatory compliance and/or with quality responsibilities within a drug development organization.

  • Working knowledge of GCP/ICH and HIPPA health information privacy requirements within a global pharmaceutical organization.

  • Strong influencing skills. Track record of building and cultivating relationships with key partners and stakeholders across organizational levels.

  • Strong negotiation skills. Ability to drive discussions and decisions toward desired end-results.

  • Strong verbal and written business communication skills. Highly adept at synthesizing and summarizing complex and/or voluminous content into clear, concise and actionable communications.

  • Strong process-orientation. Proven effectiveness in identifying, developing and implementing scalable/sustainable process and other continuous improvements to achieve organizational efficiencies and increase effectiveness.

#goodclinicalpractice #gcpcompliance #clinicalquality

#LI-KD1

4/16/21 Principal/Senior Medical (Science) Director - Neurology (SMA)  Individual contributor South San Francisco, California

Principal/Senior Medical (Science) Director - SMA 

Location: South San Francisco, CA 

Purpose 

The Principal/Senior Medical (Science) Director at Genentech puts patients and science at the center of all actions. They drive medical tactics aimed at maximizing medical progress for patients. They collaborate to drive timely data generation and dissemination. They are expected to maintain an in depth understanding of the medical strategy and relevant clinical and payer issues, while ensuring Genentech's partners understand key trends and shifts in the external healthcare landscape. They serve as the guardian for high standards of compliance, ethics and safety. This position sits within a network of clinical and scientific experts, and therefore may be performing a variety of medical activities, as needed. 

The Position 

We are seeking a dynamic medical leader to focus in the area of Spinal Muscular Atrophy. This lead will join the US Medical Affairs network of scientists focusing on Neurology and will provide exceptional clinical and scientific leadership for medical affairs activities in the area of SMA and related disorders. With an aim of generating and communicating medical evidence that helps practitioners, patients and payers make good health care decisions. The successful candidate exhibits outstanding communication and leadership skills and builds strong relationships with key stakeholders in the SMA and other neuro rare disease community. 

This individual will be responsible for the execution of medical activities within the context of the US health care environment that include clinical study design and monitoring; clinical and health economic data analysis, interpretation and publications; medical content development and review; clinical training and insights generation; and a focus on scientific exchange and collaboration. 

This position will also serve as a leader to the US Medical function within cross functional teams and initiatives at Genentech, within the Roche global organization, and will lead and participate in external customer facing engagements. In addition to strong communication skills, this position requires the ability to lead fit-for-purpose teams in a matrix environment, flexibility in prioritizing work, and a mindset to engage in purposeful partnerships to solve complex multi-disciplinary challenges. 

As a key member of the medical team, this position is expected to: 

  • Provide the medical perspective for the SMA program and to a broader network of Medical Affairs professionals in the home and field organizations 

  • Design, execute, and monitor clinical studies spanning the product lifecycle 

  • Represent Genentech Medical Affairs externally at key meetings

  • Develop scientific partnerships with therapeutic area experts and execute on collaborations.

  • Lead efficient implementation of medical tactics, leveraging the network of relevant expertise and insights 

  • Execute on USMA/ global clinical trial activities conducted as part of Medical Affairs

  • Provide clinically meaningful perspective for regulatory and other scientific communications 

  • Ensure medical and product information and communications are provided in compliance with Genentech - Roche policies 

  • Act as a guardian for high standards of compliance, ethics and safety; putting patients at the center of all actions 

  • Participate and thrive in an interactive, purpose driven culture 

Who you are 

A leader with a strong scientific and clinical background who has a passion for making medical progress for people affected by NMO and MS. You are looking for a company where you have the opportunity to positively impact peoples’ health, and where a job title does not define who you are professionally but is the starting point of what you can achieve. 

Qualifications, Experience and Skills 

  • MD, PharmD or PhD required

  • Clinical experience in Neurology---preferred

  • Minimum 5-10 years of relevant clinical / medical pharmaceutical/biotechnology industry experience 

  • Experience of pre-approval drug development trials and/or post marketing medical evidence generation, including expertise in controlled and observational study designs, data analysis, and clinical/health economic interpretations

  • Understanding of the US health care environment including the payer landscape, evidence based medicine tools and practices, and health technology assessment

  • Ability to navigate complex and challenging situations and flex and thrive in an ambiguous environment.

  • The position may require up to an additional 20% time traveling. 

CMG Operating Principles 

I put the patient first, always 

I am obsessed with meeting customer needs I act on behalf of the whole company, not just my team I am inclusive 

I have a growth mindset 

I act with urgency 

I am accountable 

I radically simplify and prioritize for impact I follow the science 

I build our reputation 

4/16/21 Manager, Frontline Engineering (Upstream) Manager with direct reports Vacaville, California

At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity, and diversity.  We believe every employee makes a difference. We are passionate about transforming patients’ lives. We are courageous in both decision and action, we believe that good business means a better world.

The focus of the Vacaville Operations Facility is Drug Substance bulk manufacturing. We have a passion for science, technology, innovation, professional development, and diversity and inclusion.  We are also deeply respected for our unique and special culture; one that centers around the people we attract and hire.  Our Pharma vision is to have a greater overall patient benefit and impact.  This focus includes personalized healthcare, designing the processes with the patient in mind, and improving their quality of life.  We hope you consider joining our team and being a part of one of the largest biotechnology facilities in the world! 

Job Summary:

Leadership & People Management:

  • Leads and manages an area’s process systems within Biopharmaceutical manufacturing facilities on site. 

  • Provides tactical guidance, arbitrates and prioritizes group activities, and implements resource loading and unloading for areas with 

  • Coordinates and interacts Quality / Validation; QA; Manufacturing Science and Technology (MSAT) group; Facilities, Engineering, Maintenance; Environmental, Health & Safety (SHE); Manufacturing teams; Manufacturing Planners / Schedulers; Material Management group 

  • Collaborates and assures strategic project target completions and technical competency in Stage Gate project reviews, Site Management and Stakeholders meetings, Product Councils and Steering Committees 

  • Provides arbitration for the staffing and technical challenges affecting multiple System Classes 

  • Be able to step in and act as a System Owner of any System Class in their area if required

  • Participates and provides guidance in Stage Gate project reviews, Site Management and Stakeholders meetings, Product Councils as related to the area of responsibility (upstream or downstream)

  • Provides mentoring and guidance to the team members as appropriate  

  • Presents and participates in the industry-wide collaborative efforts (e.g. ISPE, PDA, AIChE) as relates to all aspects of the System Class design, installation, commissioning, operation, maintenance / inspection

Technical:

  • Accountable for the System Class operational performance, availability, mechanical / structural / electrical integrity and reliability.

  • Strong ability to size, rate, select, and scale the process system components that include equipment, instrumentation, valves, and piping

  • Provides oversight and manages technical activities of area related studies, projects, and investigations, communicating the results to the Manufacturing Leadership Team

  • Manages and prioritizes System Owner’s response to emergent events that could interrupt production, while providing technical leadership to the initial assessment of events that have the potential to impact area safety and product quality

  • Coordinates and interprets operational data extracted from Batch Historian, through field observations, or compilation of study data, communicating the results to other groups and management

  • Accountable for the correctness of the Automation software updates and execution as it relates to the System Class

  • Initiates, coordinates, and approves the Root Cause Analysis and applicable troubleshooting for the System Class

  • Accountable and responsible for generation, review, approval, and life cycle maintenance of critical process requirement documents (e.g. Process URS, Process FS)

  • Accountable for correctness of project critical documentation (e.g. specifications, data sheets, calculations, P&IDs / PFDs, Vendor Drawings and Turn-over Packages) that may affect the System Class performance and integrity

  • Manages the development of area SOPs, protocols, as well other manufacturing documents

  • Coordinates Systems’ status, availability, and impact across all relevant projects and activities that may affect the system in technical, cost or schedule related manner

  • Provides oversight and approval to multiple projects implementation steps as it relates to the System Class

Job Requirements

Education:

  • Bachelor’s Degree in Chemical or Bio-Chemical Engineering is preferred. 

  • Degrees in Mechanical and Nuclear Engineering or equivalent operating experience along with a Bachelor of Science in relevant scientific disciplines is considered.

Experience

  • 10-15 years of experience in the Biotech Industry

    Over 5 years of experience with Upstream Commercial Cell Culture processing

    At least 3 years of people's management experience having direct reports

Knowledge/Skills/Competencies

  • Demonstrates a complete quantitative and qualitative understanding of process engineering principles and concepts with an ability to provide solutions to complex technical problems in the bio-pharmaceutical processing

  • Complete technical, design, and operational competence of specific System Class (es) within area of responsibility, and good understanding of complete Mammalian Cell Culture Process Upstream, Downstream, Process Supports and Utilities functions

  • Capable of providing creative, out of the box approaches to design and operating challenges

  • Proven ability to understand Project Management concepts and execution phases / deliverables for each phase

  • Working knowledge of applicable Quality Systems (e.g. Clean Utilities, sampling /QC) 

  • Working knowledge of cGMP practices

  • Excellent written, verbal, and presentation skills with proven ability to use market available software

#LI-AD1

#PTCareers

4/16/21 Field Applications Specialist- Tissue Diagnostics, Roche Support Network Individual contributor Colorado

Territory: Denver, Colorado

Location: Must live in or be willing to relocate within 50 miles of Denver, Colorado

Job Facts:

This is an exciting time to join Roche Support Network. If you are passionate for problem solving then this is the position for you! As a research-focused healthcare company, Roche discovers, develops and provides innovative diagnostics and therapeutic products and services that deliver significant benefits to patients and healthcare professionals - from early detection and prevention of diseases to diagnostics, treatment and treatment monitoring. Roche is a successful company that can offer exciting career opportunities. We encourage and support your development in areas of your interest which will prepare you for the next level in your career path. We know that people are responsible for our success and we value our employees. Our commitment is to create a work environment where feeling valued, respected, and empowered is a daily experience.

The Opportunity:

The Roche Support Network group is committed to providing industry-defining support to its customers. As a Field Applications Specialist, you will have the opportunity to travel and demonstrate your expertise as a technical repair and/or installation specialist for Roche assigned product lines, and provide valued service to your laboratory customers in an assigned territory.

  • Serves as the Roche liaison and expert with the field and customers on all consultative, administrative and technical installation matters pertaining to implementation of assigned Roche systems. 

  • Serves as the lead technical expert for field support staff by supporting the local support team with the identification, analysis, and execution of complex hardware instrument implementations, including pre-installation planning and resolution of post-implementation hardware issues. 

  • Provides analysis, feedback and recommendations on product failure trends and service ability issues.

  • Diagnoses mechanical, hardware, software and system failure, using advanced knowledge, experience and skills. 

  • Determines most cost effective repair/resolution to minimize delay to the installation timeline. 

  • Responsible for maximizing customer satisfaction with Roche hardware installations. 

  • Promotes effective, positive, and productive communications among team members to ensure and maximize satisfaction of customers.

  • Manages assigned installations at a level that promotes goodwill, confidence and credibility in order to exceed customer expectations in terms of product, installation and support quality.

  • Will oversee and assess quality of installation teams’ work and provide feedback to regional lead engineers regarding customer site readiness, delivery, and install resource scheduling.

Who you are:

  • Bachelor’s degree in Biology, Chemistry, Cell Biology or Biochemistry, or Bachelor’s degree in Medical Technology, and/or relevant experience.

  • 3 years of previous experience in a clinical laboratory· 

  • Effective written/verbal communication skills as well as project management experience.

  • Effective customer consultative skills which includes  a positive attitude, helpful customer interaction, and maintenance of ongoing customer relationships.

  • Can work as a field based individual contributor with independence and autonomy.

For Colorado-based applicants, the expected salary range for this position is $61,000 and $113,000. Actual pay will be determined based on experience, qualifications, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits listed below.

Benefits

Roche offers highly competitive benefit plans and programs, including: 

      Medical, dental and vision insurance

      401(k) and 401(k) matching

      Paid time off

      Company Car (field employees)

#LI-MG1

4/16/21 Field Applications Specialist, Chemistry- San Diego, CA Individual contributor California

Territory: San Diego, CA

Location: Must live in or be willing to relocate within 50 miles of San Diego, CA

Job Facts:

This is an exciting time to join Roche Support Network. If you are passionate for problem solving then this is the position for you! As a research-focused healthcare company, Roche discovers, develops and provides innovative diagnostics and therapeutic products and services that deliver significant benefits to patients and healthcare professionals - from early detection and prevention of diseases to diagnostics, treatment and treatment monitoring. Roche is a successful company that can offer exciting career opportunities. We encourage and support your development in areas of your interest which will prepare you for the next level in your career path. We know that people are responsible for our success and we value our employees. Our commitment is to create a work environment where feeling valued, respected, and empowered is a daily experience.

The Opportunity:

The Roche Support Network group is committed to providing industry-defining support to its customers. As a Field Applications Specialist, you will have the opportunity to travel and demonstrate your expertise as a technical repair and/or installation specialist for Roche assigned product lines, and provide valued service to your laboratory customers in an assigned territory.

  • Serves as the Roche liaison and expert with the field and customers on all consultative, administrative and technical installation matters pertaining to implementation of assigned Roche systems. 

  • Serves as the lead technical expert for field support staff by supporting the local support team with the identification, analysis, and execution of complex hardware instrument implementations, including pre-installation planning and resolution of post-implementation hardware issues. 

  • Provides analysis, feedback and recommendations on product failure trends and service ability issues.

  • Diagnoses mechanical, hardware, software and system failure, using advanced knowledge, experience and skills. 

  • Determines most cost effective repair/resolution to minimize delay to the installation timeline. 

  • Responsible for maximizing customer satisfaction with Roche hardware installations. 

  • Promotes effective, positive, and productive communications among team members to ensure and maximize satisfaction of customers.

  • Manages assigned installations at a level that promotes goodwill, confidence and credibility in order to exceed customer expectations in terms of product, installation and support quality.

  • Will oversee and assess quality of installation teams’ work and provide feedback to regional lead engineers regarding customer site readiness, delivery, and install resource scheduling.

Who you are:

  • Bachelor’s degree in Biology, Chemistry, Cell Biology or Biochemistry, or Bachelor’s degree in Medical Technology, and/or relevant experience.

  • 3 years of previous experience in a clinical laboratory· 

  • Effective written/verbal communication skills as well as project management experience.

  • Effective customer consultative skills which includes  a positive attitude, helpful customer interaction, and maintenance of ongoing customer relationships.

  • Can work as a field based individual contributor with independence and autonomy.

Colorado applicants are not eligible.

#LI-MG1

4/15/21 Technical Development Scientist Individual contributor South San Francisco, California

***Please note this role may be filled at the Associate Scientist or Scientist level***

We are looking for a highly motivated microbiologist to join the Process Virology team in Purification Development within US Pharm Technical Development (PTDU).   The candidate will play a critical role in developing rapid microbiological methods in close collaboration with Cell Therapy and iNeST(an RNA-based individualized cancer immunotherapy) teams.

Extensive hands-on experience and in-depth knowledge are required 

in microbial physiology, bacteria growth and media development, and molecular biology analytical methods such as PCR or NGS based methods.  Creative thinking, scientific rigor, experience in method development are essential. The selected individual is expected to work independently as well as in a team setting to design and execute experiments and strategies. 

Main responsibilities

  • Development of rapid microbiological methods with similar or better assay performance than compendial methods

  • Development of PCR and NGS based rapid sterility methods to support new modality process/product development.

  • Design, execute, and analyze experiments, and present results to cross-functional teams

  • Author technical reports in support of microbiological method development activities

  • Work collaboratively with the appropriate functions in PTD and microbiology SMEs in the Roche network.

Requirements

  • PhD or Bachelors degree with minimum 5 year relevant experience or Masters with minimum 3 years relevant experience; Degree in microbiology, biochemistry, molecular biology or a related discipline with industrial or clinical microbiology experience.

  • Candidates must have a strong background in more than one of the following areas: microbial physiology, microbial fermentation process development, microbiological tests, molecular biological methods such as PCR or NGS.

  • Knowledge and experience in novel microbiological methods.

  • Demonstrated trouble-shooting capabilities and problem-solving skills, and hands-on work in the lab.

  • High flexibility and strong work ethic.

  • A ‘can-do’ attitude, with the ability to deal with ambiguity, manage complex situations and to “think out of the box” and challenge the status quo

  • Demonstrated ability to coordinate multiple tasks and manage priorities

  • Strong verbal and written communication skills including the ability to present scientific results clearly and concisely

  • A strong desire to work in a collaborative, multi-disciplinary environment;

  • Customer-focused, motivated, detail-oriented, with excellent organizational skills

#LI-DW1

#PTcareers

#PTD

4/15/21 Senior Marketing Manager Individual contributor South San Francisco, California

Position Summary

With two recent launches in hemophilia A, HEMLIBRA is making tremendous impact on the lives of those living with this rare disease.  As a brand experiencing rapid growth in a highly switch adverse and competitive market, we are looking for a Senior Marketing Manager with marketing experience to join the team and further drive patient impact.

The Senior Marketing Manager will continuously deliver essential marketing capabilities (eg brand and company positioning, content development, digital development, channel optimization etc) and business acumen (hemophilia healthcare ecosystem, customer knowledge) that enable the development and execution of the integrated product value proposition. 

This Senior Marketing Manager position will report to a HEMLIBRA Marketing Team Lead.   The individual will be able to flex across the business and deliver tactics that reach patients, providers and/or payers dependent upon the business priority.  The ideal candidate will understand core marketing principles, demonstrate strong business acumen as well as have a passion for putting patients first. This individual also lives the CMG Operating Principles; I put the patient first, always; I am obsessed with meeting customer needs; I act on behalf of the whole company, not just my team; I am inclusive; I build a culture of trust; I have a growth mindset; I act with urgency; I am accountable; I radically simplify and prioritize for impact; I follow the science and I build our reputation. 

Key Responsibilities

  • Supports the development and execution of HEMLIBRA’s value proposition and the end-to-end customer experience
  • Responsible for ensuring a simplified, well-integrated product message and position across multiple marketing platforms
  • Partners effectively with thought leader liaison/ecosystem marketers and others to effectively garner customer insights to prioritize activities in line with strategic focus areas
  • Responsible for optimizing all marketing materials, including branding, messaging, and channel mix for target customers (e.g. patients, providers, payers)
  • Identifies and works regularly with internal network partners and external resources to deliver product marketing activities
  • Monitors marketing impact and customer satisfaction to optimize campaigns and drive customer and business priorities and outcomes
  • Partners with the Promotional Review Committee (PRC), including Legal and Regulatory, to ensure development, approval, and pull-through of compliant and effective promotional tactics
  • Leads and/or participates in flexibly deployed work teams across the CMG network, contributing novel ideas or approaches based on their areas of expertise
  • Works autonomously to make decisions and act, in close alignment with the full product value proposition, customer positioning, and Squad priorities

Skills and Competencies

Marketing Execution / Customer Experience

  • Experience performing personal and non-personal promotion to drive belief and behavior change with customers is strongly preferred
  • Has adopted new ways of working based on learnings from prior experiences to continuously and efficiently improve our work
  • Proven track record of effectively executing tactics after PRC approval; experience with field pull through preferred

I Act with Urgency / I Am Accountable

  • Demonstrated bias for action, will make decisions without perfect information
  • Ability to advice seek, co-create and iterate to test ideas fast
  • Willing and able to lead and influence without authority and deliver

  • Strong working knowledge of all aspects of brand marketing to include positioning, branding, campaign development and channel mix
  • Breadth of experience in product/therapeutic area, access marketing and multichannel marketing
  • Ability to influence and inspire individuals and teams across the CMG network
  • Strong customer orientation and focus
  • Team player, known for collaboration and coaching others
  • Ability to flex and thrive in an ambiguous environment undergoing transformational change
  • Strong analytical skills to effectively utilize research and behavioral data to shape strategies and tactics
  • Strong agency partnership and management skills
  • Ability to translate strategic direction into action plan for self, and make progress in the face of ambiguity
  • Good judgment in recognizing the distinction between "good enough" and perfection
  • Embraces change, embodies a continuous improvement mindset, and exemplifies agile principles in day-to-day activities
  • Knowledge of each critical customer type e.g. patients, providers, payers as well as their experiences and their needs end-to-end
  • Ability to think with an enterprise mindset

Recommended Candidate Profile

  • Bachelor’s degree in Marketing / Business preferred
  • MBA or other related graduate level degree preferred
  • 10-12 years of experience with the majority working in a product marketing function
  • Experience in the managed care, pharmaceutical or biotech industry/pharmaceutical or biotech field sales
  • Marketing experience in other relevant industries
  • Experience in creating marketing strategies, plans and tactics that have strengthened market positioning and driven high-value customer and business outcomes

LI-OC1

4/15/21 Head, China Affiliate Strategy Hub Executive (Director/VP) Shanghai

Key Responsibilities 

Lead the development of a robust affiliate and portfolio strategy to deliver on Roche Pharma long-term ambition.

Act as catalyst between China affiliate and global network, optimize life cycle management from development to commercial activities, and provide consolidated input to global strategic plans such as IDCP to ensure early launch of innovative and tailored pipeline for Chinese patients.

Synthesize business insights collected from internal and external stakeholders including competitive intelligence, market research or other related activities to enable informed portfolio decisions.

Provide strategic guidance and enablement to cross-functional squad teams in the development and execution of integrated therapeutic area strategies and patient centric solutions to improve patient outcomes.

To continuously sense the external environment and identify strategic opportunities including external partnerships that help enable better outcomes for Chinese patients and the Roche Pharma vision. 

Bring and foster life cycle management expertise development in Roche China and role model VACC and agile ways of working to mobilize resource locally and globally.

Groom and develop local talents for local/global leadership pipeline and enable global talents exchange in both direction.



Training/Education: 

BS/BA in Business Administration or Life Sciences, MD, PhD, MBA preferred

Experience:             

10 + years’ multidisciplinary experience in the pharmaceutical or biotechnology industry (e.g., global product strategy, research, clinical development, regulatory, commercial operations, portfolio management etc.) 

Demonstrable record in completing and implementing attainable business and/or development plans for multiple products 

Proven track record in leading integrated strategy development

Proven track record leading/mobilize cross-functional teams to work in an agile way, i.e. lead cross functional squad team;



Knowledge, Skills, and Abilities:

In-depth knowledge of drug development and commercialization processes (pre-clinical and clinical Phase I - IV drug development experience is strongly preferred)

In-depth understanding of strategic, scientific, regulatory and commercial aspects of formulation and device development from evaluation to registration, to include line extensions of small molecules and biologics

In-depth knowledge of portfolio life cycle management with strategic resource allocation insights

Sound understanding of market insights, payer and HCP needs for aspects of drug delivery across Therapeutic Areas

Strong knowledge of regulatory affairs in the pharmaceutical/biotechnology industry

Strong grasp/understanding of products and the surrounding marketplace, including health economics and related dynamics for corporate/TA strategy optimization

Knowledge of, and experience working with, business development, alliance partners or licensing activities

Outstanding financial acumen: capable of driving and managing large-scale revenue and expense responsibilities



LEADERSHIP/ MINDSETS

Purpose driven and patient/customer centric

Role model VACC leadership 

Strong leadership skills: can build vision and strategy and lead others in the accomplishment of this.

Has passion in developing and building high performing teams.

Exhibits professional maturity, confidence and resilience.

Influencing skills: proven abilities to influence without authority 

Multicultural awareness, inclusive leader to embrace diversity

Adopts agile ways of working and has growth mindset to embrace change and ambiguity

4/15/21 Senior Marketing Manager - Xolair Manager without direct reports South San Francisco, California

The Product Marketing organization establishes the full product value proposition and product positioning for all customer types. The Marketing organization is also accountable to design outstanding customer experiences and works with networked partners (e.g. Field Sales, Genentech Business Operations) to deliver these experiences. A marketer uses resources and their network to make meaningful progress with patients and customers each day. This individual also lives the CMG Operating Principles (I put the patient first always; I am tenacious in meeting customer needs; I act on behalf of the whole company, not just my own team; I am accountable; I use time and resources to create the most impact; I am inclusive; I have a bias for action; I build a culture of trust; My career will thrive as I grow my capabilities and increase my impact; I act with integrity).

Key Job Responsibilities

• Supports the development and execution of the Xolair value proposition, customer positioning, and the end-to-end customer experience

• Responsible for optimizing all marketing materials, including branding, messaging, and channel mix for target customers. Creates new materials when necessary to address a customer need

• Uses and commissions appropriate marketing research needed to drive the product's overall market positioning and to inform the optimal end-to-end customer experience

• Identifies and works regularly with internal network partners and external resources to deliver product marketing activities

• Responsible for ensuring a seamless, well-integrated product message and position across multiple marketing platforms

• Accountable for high quality, compliant execution across all marketing platforms and customer types (e.g. patients, providers, organized customers)

• Prioritizes and creates personal messages and resources for field-based channels in coordination with non-personal messages and resources

• Monitors marketing activity usage, performance, and customer satisfaction to optimize campaigns and drive customer and business outcomes

• Partners with the Promotional Review Committee (PRC), including Legal and Regulatory, to ensure development, approval, and pull-through of compliant and effective promotional tactics

• Leads and/or participates in flexibly deployed work teams across the CMG network, contributing novel ideas or approaches based on their areas of expertise

• Works autonomously to make decisions and act, in close alignment with the full product value proposition, customer positioning, and Squad priorities

Demonstrates Proficiency within the following Key Capability Areas

• Customer, Product and Market Insights:  Ability to understand, integrate and synthesize insights across customers, competitors, therapeutic or business areas and markets to inform customer-centric business decisions

• Financial Acumen:  Ability to use financial information and capabilities to inform investment decisions, manage external partners and budgets, and drive sound business decisions

Value Creation: Ability to develop and communicate the unique value and promise that Genentech’s products and solutions provide to its customers

• Strong agency management skills

• Business Strategy: Ability to make choices and identify key metrics to deliver measurable customer and financial objectives that drive business forward.

• Customer Experience: Ability to create and execute customer-centric programs and solutions to positively and meaningfully engage customers across the care continuum

• Market Execution: Ability to create, implement and iterate impactful tactics with clear and measurable outcomes to the business and the customer

• Account Marketing and Partnerships: Ability to identify, develop and maximize effective working relationships with customers and partners to gain alignment on customer needs and optimize business and customer outcomes

Skills and Competencies

• Strong working knowledge of all aspects of brand marketing to include positioning, branding, campaign development and channel mix

• Knowledge of the healthcare ecosystem including health economics, policy and the regulatory environment

• Knowledge of each critical customer type e.g. patients, providers, organized customers as well as their experiences and their needs end-to-end

• Ability to think with an enterprise mindset

• Ability to influence and inspire individuals and teams across the CMG network

• Breadth of experience in product/therapeutic area, access marketing and multichannel marketing

• Ability to flex and thrive in an ambiguous environment undergoing transformational change

• Strong customer orientation and focus

• Strong analytical skills to effectively utilize research and behavioral data to shape strategies and tactics

• Strong agency management skills

• Ability to translate strategic direction into action plan for self, and make progress in the face of ambiguity • Good judgment in recognizing the distinction between "good enough" and perfection • Embraces change, embodies a continuous improvement mindset, and exemplifies agile principles in day-to-day activities

Qualifications

• Bachelors degree in Marketing / Business preferred

• MBA or other related graduate level degree preferred

Experience

• 12-15 years of experience with the majority working in a product marketing function

• Experience in the managed care, pharmaceutical or biotech industry/pharmaceutical or biotech field sales is mandatory

• Experience in creating marketing strategies, plans and tactics that have strengthened market positioning and driven high-value customer and business outcomes

LI-OC1

4/15/21 National Healthcare Provider Insights Lead - Field Analytics and Insights (FAI) Individual contributor South San Francisco, California

General Position Summary & Purpose

Genentech is a team of highly dedicated, passionate individuals. We are a place where people unite around a single purpose and an ambitious vision. Together, we aspire to deliver ever better health outcomes for patients while lowering overall healthcare costs.

Field Analytics & Insights (FAI) is a field-focused team within Strategic Analytics and Intelligence (SAI) that plays an advising role in helping Genentech achieve its goals and objectives through field teams and the functions that support them.  FAI plays a critical role in enabling field teams with data analytics, insights, incentives, and tools teams need to effectively prioritize, plan, and manage efforts across the customer spectrum and life cycle of our products. 

In this role, you will support the National Supply and Care Delivery Leadership Team in FAI by providing deep analytics, insights, and intelligence to make effective market and customer decisions to lead key healthcare .  You will partner with many functions in SAI & throughout the Genentech organization and cross-functional teams to better understand and assess the customer issues that impact distributors, 340B institutions, national health systems, etc. for the Genentech portfolio. You may also provide support as required for effective pull through and execution of market and customer strategies and tactics. 

Relevant customer support could include:

  • Hospital GPOs (i.e. Premier)

  • Health Systems (i.e. Tenet)

  • Healthcare Distributors (i.e. Cardinal)

PRIMARY RESPONSIBILITIES:

  • Serve as primary analytics and intelligence advisor to the National Supply and Care Delivery Leadership Team to make data-driven decisions by market dynamics and product objectives while pushing portfolio priorities.

    • Field force customer alignment and targeting

    • Opportunity analysis

    • Account analysis and planning

    • Market landscape / situational analysis

    • Business review and variance analysis to goals

    • Portfolio pull through and national market optimization

  • Collaborate with partner groups to deliver business insights that are actionable and relevant, while considering a holistic view of the organization and portfolio

  • Demonstrate a strategic, agile and customer-centric mindset to achieving business objectives

  • Contribute to and lead department wide initiatives

  • May support his/her manager in training and mentoring less experienced individuals    

  • Successfully demonstrate our commitment to compliance by adhering to the US Pharma Code of Conduct and all relevant Genentech Compliance Policies as well as completing all training

QUALIFICATIONS & EXPERIENCE:

In hiring new employees, we look for people who are inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture.  We are seeking an individual with:

  • Minimum BS/BA degree with Mathematics/Statistics, Business, Healthcare concentration preferred.  MBA or advanced degree desired.

  • Eight or more years' work experience in management consulting, strategy or other analytical work in pharmaceutical, biotechnology, healthcare or other industries

  • Healthcare managed markets knowledge preferred

  • Demonstrated track record of leading and influencing cross functional teams and Senior Leaders

  • Experience developing and using Excel-based models as well as other modeling platforms

  • Experience with analytical tools (e.g., R, SQL, SAS, etc.) and BI / reporting tools (e.g., Qlik)

  • Strong strategic thinking and structured, problem solving skills

  • Strong attention to detail and project management skills

  • Strong communication skills, both written and verbal, and facilitation skills

  • Business travel may be required

ROCHE CORE COMPETENCIES

  • Technical and Business Expertise: Has deep healthcare and/or biopharma background and expertise in analytics; Applies knowledge on emerging and evolving trends to improve results

  • Strategic Agility: Prioritizes efforts appropriately to address largest business opportunities; Connects work to broader organizational goals

  • Teamwork and Collaboration: Able to pull large teams of people together around a common goal; Able to work through and influence team to drive outcomes

  • Achieving Results: Is goal-oriented, persistent; driven to achieve objectives; Able to influence data-driven strategy and decision making by Sr. Leaders

  • Communication: Effective verbal and written communicator; Is adept at communicating across multiple levels of Genentech internal organization

CMG OPERATING PRINCIPLES

I put the patient first, always.

I am obsessed with meeting customer needs.

I act on behalf of the whole company, not just my team.

I am inclusive.

I build a culture of trust.

I have a growth mindset.

I act with urgency.

I am accountable.

I radically simplify and prioritize for impact.

I follow the science.

I build our reputation.

#LI-KG

4/15/21 Program Manager - Drug Development

Program Manager / Sr. Program Manager

The leveling for this position is based on experience.

At Genentech, we focus on fostering belonging for our people, advancing inclusive research and health equity for all patients, and transforming society by investing in transformative partnerships that strengthen diversity and inclusion across healthcare, education and within all communities. Remaining one of the world’s top biomedical research institutions requires us to innovate at all levels, utilizing unique perspectives and backgrounds, in order to improve the outcomes for our patients.

The Research and Early Development Project Management and Resource

Planning Group is responsible for driving drug development molecule, strategy, and partnering teams to advance science and medicine for the patients.

The Program Manager role is responsible for managing drug development

programs to successful and timely decision points from Late Stage Research through Proof of Concept. This role contributes to the definition of program strategy and guides the multi-disciplinary core and sub teams to deliver on

program objectives. Additional responsibilities include the following:

  • Establish and maintain functionally integrated program schedules to enable accurate program, financial and portfolio analyses and ensure accurate inputs are provided into business planning processes. Ensure alignment with program sub-teams and functional partners.
  • Oversee and prepare program team budget including resources and costs, collaborating with Finance and other cross-functional departments.
  • Communicate, document and archive program team activities and decisions. Act as a primary contact for program team relad information.
  • Proactively identify and manage risks with scenario planning and risk mitigation plans.
  • Facilitate program team meetings, cross-functional communication and decision making, ensuring alignment with internal and external stakeholders.
  • Identify, recommend and implement opportunities for streamlining team and business processes.
  • Ensure the team achieves and maintains a high-level of sustainable performance by contributing to appropriate team management best practices.

Successful candidates will meet the following requirements:

  • Minimum 2 years of multi-disciplinary experience in the biotech/pharmaceutical industry. Relevant experience in a related industry or academic setting will also be considered.
  • Prior direct project/program management or similar experience.
  • Experience in drug development with knowledge of the overall drug development process. Relevant experience in a related scientific setting will also be considered.
  • Experience using Project Management software to manage complex program timelines and resources is a plus.
  • Bachelor's degree in the Life Sciences or other relevant discipline. Advanced degree is desirable.

At a minimum, strong candidates will demonstrate the following:

  • Strong proficiency with project/program management practices, tools and methodology.
  • Financial acumen with capability to plan and oversee program budgets and product valuations.
  • Understanding of portfolio management concepts.
  • Excellent interpersonal skills with the ability to develop effective important relationships with customers and key stakeholders.
  • Good conflict management resolution skills.
  • Excellent analytical and critical thinking skills
  • Strong communication and presentation skills with the ability to communicate complex information effectively.
  • Ability to translate strategy into action.
  • Strong influencing and negotiation skills.
  • Proven track record of good decision making and exercising sound judgment.
  • Embraces working in a culture where receiving and providing feedback is valued.
  • Results and detail-oriented.
  • Self-motivated.

4/15/21 Scientist. Physiological Chemistry Individual contributor South San Francisco, California

The Department of Physiological Chemistry at Genentech is seeking a talented Scientist with a strong background in protein biochemistry and structural biology to characterize challenging membrane and soluble proteins that regulate cell death and inflammation. This Scientist will be responsible for the production of high-quality protein reagents and their biophysical and structural characterization.  Proficiency in x-ray crystallography and/or cryo-EM methods is strongly desired.

A passion to explore the structural basis of protein-protein interactions is essential, as is a proven track-record of optimizing the expression and purification of proteins for functional and structural studies.  Hands-on experience with soluble and membrane protein classes is highly desired.

The successful candidate will be a technical expert capable of leading from the bench or through collaborations with colleagues.

Required qualifications

Ph.D. in biochemistry, biophysics, protein engineering, and/or structural biology with experience on multiple challenging protein targets.  Productive postdoctoral training and/or industry experience is expected and should be reflected in an established track-record of high impact publications.

Additional desired qualifications:

● Hands-on experience engineering and optimizing the production of challenging protein targets for structural and/or functional studies.

● Ability to generate and characterize milligram quantities of high-quality protein reagents.

● Proficiency in structure determination using X-ray crystallography and/or cryo-EM is preferred.

● Experience with protein engineering and/or design approaches.

● Analysis, design, and/or computational approaches to investigate protein complexes.

● Excellent communication, interpersonal, and organizational skills.

● Team-oriented and collaborative with a fearless attitude to tackle important biological questions.

#LI-NN1

4/15/21 Computational Biology Scientist, Cancer Immunology Individual contributor South San Francisco, California

Genentech seeks a talented and highly motivated computational biology scientist to pursue collaborative, data-driven projects in close collaboration with our Cancer Immunology Department.

Recently, exciting developments at Genentech and elsewhere have demonstrated the potential of leveraging the human immune system for effective and durable control of cancer. Our extensive bulk and single-cell/nucleus RNA-seq characterization of stromal, immune and cancer cells in samples collected from cancer immunotherapy clinical trials provide an outstanding opportunity for identification of signals that are associated with the variability in immunotherapy treatment response. This will form the basis to investigate the mechanistic basis of these observations in animal models in the laboratory.

Applicants should be able to work comfortably on an interdisciplinary team, have a strong desire to carry out data analysis and integration across various domains (High-throughput Transcriptomic, Proteomic, Epigenomic data), and apply best-in-class algorithms - or develop new algorithms - that directly address the motivating biological and clinical questions. Regular publication of scientific results is strongly encouraged. Finally, applicants should be able to effectively present complex results in a clear and concise manner that is accessible to a diverse audience of quantitative, experimental, and clinical scientists.

Who you are

  • You have a PhD in Computational Biology, Biostatistics, Bioinformatics or similar, with a strong publication record. Alternately, you have a PhD in Immunology, Molecular Biology, etc. combined with a very strong record of high-throughput data analysis, supported by publication in this area.

  • You have a solid understanding of the relevant concepts in cancer biology and genetics, or in immunology. You also have enthusiasm for learning more.

  • You have postdoctoral experience in basic or translational research either in an academic or industry setting with a record of publication in lead positions.

  • You have a broad experience with data generated by one or more high-throughput molecular assays: Next-generation sequencing, flow cytometry, etc. If you have additional experience with single-cell assays (e.g., single-cell RNA-seq or CyTOF) it is a significant plus.

  • You understand the statistical principles behind current best practices in high-throughput molecular data analysis.

  • You have a strong experience in the use of a high-level programming language such as R or Python for complex data analysis.

  • You have exceptionally strong communication, data presentation and visualization skills.

  • You enjoy working both independently and collaboratively, and feel comfortable to handle several concurrent, fast-paced projects.

What to expect from us

  • A highly collaborative and dynamic research environment where we aim to translate our understanding of cancer biology and immunology to develop personalized therapies and diagnostics to transform clinical practice to benefit patient health.

  • Access to clinical data sets and samples.

  • Access to state-of-the-art technologies and pioneering research.

  • Participation in seminar series featuring academic and industry scientists.

  • Campus-like lifestyle with a healthy work-life balance.

  • Mentored opportunities to further develop professional skills.

#LI-GL1

#bioinformatics

#computationalbiology

#gREDinformatics

4/15/21 Postdoctoral Fellow - Protein Analytical Chemistry Individual contributor South San Francisco, California

We are seeking a highly motivated, independent researcher for a postdoctoral position in the Protein Analytical Chemistry Department at Genentech. This role will focus on the structural analysis of our biotherapeutic drugs by use of hydrogen deuterium exchange mass spectrometry (HDX MS) and other analytical tools, e.g., size exclusion chromatography (SEC), differential scanning calorimetry (DSC) and other chromatographic or electrophoretic methods. Potential applications include epitope mapping, protein stability and structure-function relation studies during drug discovery and development. In addition, the candidate will be able drive their own ideas and collaborate across Genentech and Roche Global. This work will include a strong cross-functional collaboration with the multiple other Pharmaceutical Technical Development (PTD) and Genentech Early Research and Development (gRED) departments.

 

The successful candidate will be a recent PhD graduate in Analytical Chemistry, Biochemistry, Structural Biology or a related discipline. A strong publication record should provide evidence of productive, independent contributions in science and technology. The applicant must have demonstrated expertise in protein characterization using LC-MS analysis for intact mass and/or posttranslational modifications, for example, through native MS, ion mobility MS, proteomics, and ideally HOS MS technologies (HDX MS or Hydroxyl Radical Footprinting-Mass Spectrometry (HFR-MS).  Prior experience with computational structural analysis is highly desirable. The successful candidate must be highly self-motivated, capable of working independently, have excellent oral and written communication skills, and enjoy working in a collaborative setting.

4/15/21 Scientific Researcher/Senior Scientific Researcher, Neurodegeneration Individual contributor South San Francisco, California

The Position(s)

We are looking for two exceptional Scientific Researcher / Senior Scientific Researchers to join the Biomarker Discovery-OMNI department within Genentech's Research and Early Development (gRED). The candidate/s will be responsible for building and executing the biomarker discovery plans in complex neurodegenerative disorders such as Alzheimers’ and Parkinsons’ disease by leveraging human post-mortem tissue, biofluid samples and analyzing and leveraging in vitro and in vivo models of disease.

Responsibilities

Assist the team in identifying predictive, prognostic, and pharmacodynamic biomarkers for molecularly targeted therapies in AD and PD. Specific responsibilities will include: establishing and utilizing in vitro and preclinical models for biomarker discovery and enable mechanistic understanding of pathways and underlying disease biology, performing exploratory disease-oriented research from patient sample cohorts and clinical trial samples, contributing to experimental design/planning, collaborating with cross-functional groups, analyzing data, and presenting results.

Candidates will contribute to generation of 2D and 3D in vitro models of disease from human stem cells for disease modeling and biomarker discovery using imaging, hypothesis driven and hypothesis free multi-omic analysis. Further, integrate findings from disease models into analysis of human tissue and biofluids. Candidates will also work closely with colleagues at Neuroscience discovery, Proteomics-Lipidomics, Genomics, Bioinformatics and Biomarker discovery to implement multi-omic strategies for biomarker discovery for neurodegenerative disorders. 

Qualifications: 

  • PhD in a relevant field (Neuroscience, immunology, biochemistry, cell biology, molecular biology) 

  • Keen Interest in method and tool development for novel ways of biomarker discovery in neurological disorders

  • 3 or more years of Experience in Molecular and Cellular neuroscience, postdoctoral experience preferred. 

  • Record of scientific achievement with publications in high-quality peer reviewed journals that demonstrate project leadership, expertise, and knowledge

  • Evidence of collaboration; enjoy working in a multi-disciplinary team environment but are also able to work independently to design, execute, and interpret experiments

  • Clear oral/written communication

  • Excellent time management and organizational skills, attention to detail

  • Ability to integrate detailed analyses into a larger disease-oriented context

  • Experience with commonly-used data analysis methods for proteomic, RNAseq data is a plus

Examples of Desired Qualifications:  

  • Experience in generation of in vitro models of neurons and glial cells for modeling neurological disorders using genome editing, subsequent imaging and/or multiomic analysis from such samples using single cell sequencing, ATAC-seq and/or CRISPR-screens.  

  • Experience in sample preparation for LC-MS analysis and a good understanding of proteomics and/or lipidomics methods. Interpretation of LC-MS data and understanding of commonly used proteomics data analysis pipelines such as Maxquant, Spectronaut, Peaks etc.  Protein Biochemical methods such as  size exclusion chromatography, Immunoprecipitation, Immunoblotting and Elisa, experience in sub-cellular preparations such as membrane and synaptic preparations. 

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Important Information

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity protections, view the EEO is the poster.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at [email protected].

Genentech will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information.