Thursday, Oct 5, 2000

Genentech Announces 2-For-1 Stock Split Effective October 17

South San Francisco, Calif. -- October 5, 2000 --

Genentech, Inc. (NYSE: DNA) today announced that its board of directors approved a 2-for-1 split of its common stock to be effective in the form of a stock dividend. The record date of this transaction is October 17. All shareholders of record of Genentech stock at the close of business on that date will receive one additional share for each share held. The additional shares will be distributed beginning October 24. As of September 30, Genentech had 262.2 million shares outstanding.

Genentech, Inc. is a leading biotechnology company that discovers, develops, manufactures and markets human pharmaceuticals for significant unmet medical needs. Fourteen of the currently approved biotechnology products stem from Genentech science. Genentech markets nine biotechnology products directly in the United States. The company has headquarters in South San Francisco, California and is traded on the New York Stock Exchange under the symbol DNA.

# # #