Tuesday, Dec 21, 2004

Genentech Announces January 10 Webcast Discussion of Earnings and Other Business Results

South San Francisco, Calif. -- December 21, 2004 --

Genentech, Inc. (NYSE: DNA) will announce its 2004 4th quarter and year-end earnings on Monday, January 10, 2005, after the markets close.

The announcement will be followed by a live webcast at 2:15 p.m. Pacific Time of a discussion by Genentech management of the earnings and other business results. The webcast can be accessed on Genentech's website at http://www.gene.com and will be archived and available for replay until 5:00 p.m. Pacific Time on January 24, 2005.

An audio replay of the webcast will be available beginning at 5:15 p.m. Pacific Time on January 10, 2005 through 5:15 p.m. Pacific Time on January 17, 2005. Access numbers for this replay are: 1-800-642-1687 (U.S./Canada) and 1-706-645-9291 (international); Conference ID number is 2737495.

About Genentech
Genentech is a leading biotechnology company that discovers, develops, manufactures, and commercializes biotherapeutics for significant unmet medical needs. A considerable number of the currently approved biotechnology products originated from, or are based on, Genentech science. Genentech manufactures and commercializes multiple biotechnology products directly in the United States, and receives royalties or other income from companies that are licensed to market its products outside of the United States. The company has headquarters in South San Francisco, Calif., and is traded on the New York Stock Exchange under the symbol DNA. For additional information about the company, please visit http://www.gene.com.