Focus on Immunology

We're constantly growing our expertise in Immunology so that we can continue to discover and develop innovative medicines for patients living with debilitating diseases, such as lupus erythematosus, asthma, inflammatory bowel disease, and idiopathic pulmonary fibrosis.

At Genentech our research and discovery efforts into aspects of innate and adaptive immunity are applied to the understanding and treatment of autoimmune and inflammatory disorders. A greater understanding of basic mechanisms of immune cell function creates scientific opportunities to affect the treatment of autoimmune, inflammatory, and fibrotic diseases. We also rely on human patient samples and data from observational and interventional clinical trials to define the pathogenic mechanisms underlying unmet medical needs in complex chronic diseases.

Key Publications

Science Translational Medicine, August 2015
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
Nature, December 2014
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
Nature, August 2014
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
Nature, February 2014
A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3