Aditya Murthy
Senior Scientist, Cancer Immunology
Postdoc Mentor
"I am thrilled to be part of a research community that strives to transform fundamentally important scientific discoveries into novel therapies."
10
Years at Genentech
13
Publications
2
Awards & Honors
The advent of genome-wide association studies (GWAS) has enabled true forward-genetics based investigations of devastating yet genetically complex chronic inflammatory diseases. I joined Genentech as a post-doctoral fellow in 2011 to investigate the contribution of host genetics on inflammatory bowel disease using GWAS as a starting point. As a postdoc, I witnessed how world-class scientific expertise across disciplines could collaborate to drive rapid progress in our understanding of human immunology, from genetic associations to functional molecular mechanisms. I was excited for the opportunity to translate these learnings into a new avenue of study, when I started my own research program in Cancer Immunology in 2014.
Currently, my group investigates GWAS-based immuno-regulatory pathways in cancer immunology. We aim to exploit the insights gained from human genetics of inflammatory diseases towards therapeutic avenues that engender anti-tumor immunity.
Featured Publication
Controlling inflammation by selective autophagy.
Cell Death Differ. 2018 May;25(5):825-827.
Lim J, Murthy A.
A Crohn0s disease variant in Atg16l1 enhances its degradation by caspase 3.
Nature. 2014 Feb 27;506(7489):456-62.
Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, Noubade R, Roose-Girma M, DeVoss J, Diehl L, Graham RR, van Lookeren Campagne M.
My Focus
My research program currently has 3 focus areas:
- We investigate the process of lysosomal degradation via autophagy, mechanisms which drive autophagic cargo selection, and its role in the immune response
- We glean relevant pathways identified from GWAS of autoimmune and chronic inflammatory diseases to model their consequence on anti-tumor immunity
- We utilize forward genetics approaches to identify pathways stimulating the innate inflammatory response in myeloid cells
Publications
Autophagy, ISSN: 15548635 15548627
Daniel J. Klionsky; Amal Kamal Abdel-Aziz; Sara Abdelfatah; Mahmoud Abdellatif; Asghar Abdoli; Steffen Abel; Hagai Abeliovich; Marie H. Abildgaard; Yakubu Princely Abudu; Abraham Acevedo-Arozena; Iannis E. Adamopoulos; Khosrow Adeli; Timon E. Adolph; Annagrazia Adornetto; Elma Aflaki; Galila Agam; Anupam Agarwal; Aggarwal; Maria Agnello; Patrizia Agostinis; Javed N. Agrewala; Alexander Agrotis; Patricia V. Aguilar; S. Tariq Ahmad; Zubair M. Ahmed; Ulises Ahumada-Castro; Sonja Aits; Shu Aizawa; Yunus Akkoc; Tonia Akoumianaki; Hafize Aysin Akpinar; Ahmed M. Al-Abd; Lina Al-Akra; Abeer Al-Gharaibeh; Moulay A. Alaoui-Jamali; Simon Alberti; Elísabet Alcocer-Gómez; Cristiano Alessandri; Muhammad Ali; M. Abdul Alim Al-Bari; Saeb Aliwaini; Javad Alizadeh; Eugènia Almacellas; Alexandru Almasan; Alicia Alonso; Guillermo D. Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Élida M. C. Álvarez; Sara Alves; Cristine Alves da Costa; Mazen M. Alzaharna; Marialaura Amadio; Consuelo Amantini; Cristina Amaral; Susanna Ambros
Communications Biology, ISSN: 23993642
Andrew Ah Young; Sterling C. Eckard; Alvin Gogineni; Hongkang Xi; S. Jack Lin; Gerhardy; Christian Cox; Qui T. Phung; Jason Hackney; Anand Kumar Katakam; Mike Reichelt; Patrick Caplazi; Paolo Manzanillo; Juan Zhang; Meron Roose-Girma; Lucinda W. Tam; Robert J (Research) Newman; Aditya Murthy; Robby Weimer; Jennie Lill; Wyne P. Lee; Michele Grimbaldeston; Daniel Kirchhofer; Menno van Lookeren Campagne
Targeting Autophagy to Treat Cancer: Challenges and Opportunities
Frontiers in Pharmacology,
Junghyun Lim; Aditya Murthy
Journal of Experimental Medicine, ISSN: 15409538 00221007
Emily C. Freund; Jaclyn Y. Lock; Jaehak Oh; Timurs Maculins; Lelia Delamarre; Christopher J. Bohlen; Benjamin Haley; Aditya Murthy
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Meron Roose-Girma; Min Xu; Brent McKenzie; Menno van Lookeren Campagne; Kim Newton; Aditya Murthy
Cell Reports, ISSN: 22111247
Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Paul Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
Cell Death and Differentiation, ISSN: 14765403 13509047
Junghyun Lim; Aditya Murthy
Nature Immunology, ISSN: 15292916 15292908
Mohammad Samie; Junghyun Lim; Erik Verschueren; Joshua Baughman; Ivan Peng; Aaron Wong; Youngsu Kwon; Yasin Senbabaoglu; Jason Hackney; Mary Keir; Brent McKenzie; Don Kirkpatrick; Menno van Lookeren Campagne; Aditya Murthy
Autophagy, ISSN: 15548635
Daniel J. Klionsky; Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo Arozena; Hiroaki Adachi; Christopher M. Adams; Peter D. Adams; Khosrow Adeli; Peter J. Adhihetty; Sharon G. Adler; Galila Agam; Rajesh Agarwal; Manish K. Aghi; Maria Agnello; Patrizia Agostinis; Patricia V. Aguilar; Julio Aguirre-Ghiso; Julio A. Aguirre-Ghiso; Edoardo M. Airoldi; Edoardo M. Airoldi; Slimane Ait-Si-Ali; Takahiko Akematsu; Emmanuel T. Akporiaye; Mohamed Al-Rubeai; Guillermo M. Albaiceta; Chris Albanese; Diego Albani; Matthew Albert; Jesus Aldudo; Hana Algül; Mehrdad Alirezaei; Iraide Alloza; Iraide Alloza; Alexandru Almasan; Maylin Almonte-Beceril; Alnemri; Covadonga Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Silvia Alvarez; Lydia Alvarez-Erviti; Sandro Alves; Giuseppina Amadoro; Atsuo Amano; Consuelo Amantini; Santiago Ambrosio; Ivano Amelio; Amal O. Amer; Mohamed Amessou; Angelika Amon; Zhenyi An; Frank A. Anania; Stig U. Andersen; Usha P. Andley; Catherine K. Andrea
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
Autophagy, ISSN: 15548627
Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo Arozena; Hiroaki Adachi; Christopher M. Adams; Peter D. Adams; Khosrow Adeli; Peter J. Adhihetty; Sharon G. Adler; Galila Agam; Rajesh Agarwal; Manish K. Aghi; Maria Agnello; Patrizia Agostinis; Patricia V. Aguilar; Julio Aguirre-Ghiso; Edoardo M. Airoldi; Slimane Ait-Si-Ali; Takahiko Akematsu; Emmanuel T. Akporiaye; Mohamed Al-Rubeai; Guillermo M. Albaiceta; Chris Albanese; Diego Albani; Matthew Albert; Jesus Aldudo; Hana Algül; Mehrdad Alirezaei; Iraide Alloza; Alexandru Almasan; Maylin Almonte-Beceril; Alnemri; Covadonga Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Silvia Alvarez; Lydia Alvarez-Erviti; Sandro Alves; Giuseppina Amadoro; Atsuo Amano; Consuelo Amantini; Santiago Ambrosio; Ivano Amelio; Amal O. Amer; Mohamed Amessou; Angelika Amon; Zhenyi An; Frank A. Anania; Stig U. Andersen; Usha P. Andley; Catherine K. Andreadi; Nathalie Andrieu-Abadie; Alberto Anel; David K. Ann; Shailendra Anoopkumar-
Cell Cycle, ISSN: 15514005
Aditya Murthy; Menno van Lookeren Campagne
Nature, ISSN: 00280836
Aditya Murthy; Yun Li; Ivan Peng; Mike Reichelt; Anand Kumar Katakam; Raj Noubade; Meron Roose-Girma; Jason DeVoss; Lauri Diehl; Rob Graham; Menno van Lookeren Campagne
Education
- University of Toronto, Ph.D., Department of Medical Biophysics – 2011
- University of Toronto, Hon. B.Sc., Human Biology – 2005
Awards & Honors
- Frederick Banting & Charles Best Canada Graduate Scholarship for doctoral research – 2009
- Doctoral thesis nominated for Canada Governor General’s Gold Medal – 1999