Genentech: Aditya Murthy | Scientist, Cancer Immunology

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Scientists / Our Scientists

"I am thrilled to be part of a research community that strives to transform fundamentally important scientific discoveries into novel therapies."

Years at Genentech

Publications

Awards & Honors

The advent of genome-wide association studies (GWAS) has enabled true forward-genetics based investigations of devastating yet genetically complex chronic inflammatory diseases. I joined Genentech as a post-doctoral fellow in 2011 to investigate the contribution of host genetics on inflammatory bowel disease using GWAS as a starting point. As a postdoc, I witnessed how world-class scientific expertise across disciplines could collaborate to drive rapid progress in our understanding of human immunology, from genetic associations to functional molecular mechanisms. I was excited for the opportunity to translate these learnings into a new avenue of study, when I started my own research program in Cancer Immunology in 2014.

Currently, my group investigates GWAS-based immuno-regulatory pathways in cancer immunology. We aim to exploit the insights gained from human genetics of inflammatory diseases towards therapeutic avenues that engender anti-tumor immunity.

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My research program currently has 3 focus areas:

We investigate the process of lysosomal degradation via autophagy, mechanisms which drive autophagic cargo selection, and its role in the immune response
We glean relevant pathways identified from GWAS of autoimmune and chronic inflammatory diseases to model their consequence on anti-tumor immunity
We utilize forward genetics approaches to identify pathways stimulating the innate inflammatory response in myeloid cells

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

eLife, ISSN: 2050084X

Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Meron Roose-Girma; Min Xu; Brent McKenzie; Menno van Lookeren Campagne; Kim Newton; Aditya Murthy

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Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity

Cell Reports, ISSN: 22111247

Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Paul Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum

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OTULIN limits cell death and inflammation by deubiquitinating LUBAC

Nature, ISSN: 14764687 00280836

Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit

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Controlling inflammation by selective autophagy

Cell Death and Differentiation, ISSN: 14765403 13509047

Junghyun Lim; Aditya Murthy

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Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Nature Immunology, ISSN: 15292916 15292908

Mohammad Samie; Junghyun Lim; Erik Verschueren; Joshua Baughman; Ivan Peng; Aaron Wong; Youngsu Kwon; Yasin Senbabaoglu; Jason Hackney; Mary Keir; Brent McKenzie; Don Kirkpatrick; Menno van Lookeren Campagne; Aditya Murthy

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy, ISSN: 15548635

Daniel J. Klionsky; Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo Arozena; Hiroaki Adachi; Christopher M. Adams; Peter D. Adams; Khosrow Adeli; Peter J. Adhihetty; Sharon G. Adler; Galila Agam; Rajesh Agarwal; Manish K. Aghi; Maria Agnello; Patrizia Agostinis; Patricia V. Aguilar; Julio Aguirre-Ghiso; Julio A. Aguirre-Ghiso; Edoardo M. Airoldi; Edoardo M. Airoldi; Slimane Ait-Si-Ali; Takahiko Akematsu; Emmanuel T. Akporiaye; Mohamed Al-Rubeai; Guillermo M. Albaiceta; Chris Albanese; Diego Albani; Matthew Albert; Jesus Aldudo; Hana Algül; Mehrdad Alirezaei; Iraide Alloza; Iraide Alloza; Alexandru Almasan; Maylin Almonte-Beceril; Alnemri; Covadonga Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Silvia Alvarez; Lydia Alvarez-Erviti; Sandro Alves; Giuseppina Amadoro; Atsuo Amano; Consuelo Amantini; Santiago Ambrosio; Ivano Amelio; Amal O. Amer; Mohamed Amessou; Angelika Amon; Zhenyi An; Frank A. Anania; Stig U. Andersen; Usha P. Andley; Catherine K. Andrea

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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Autophagy, ISSN: 15548627

Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo Arozena; Hiroaki Adachi; Christopher M. Adams; Peter D. Adams; Khosrow Adeli; Peter J. Adhihetty; Sharon G. Adler; Galila Agam; Rajesh Agarwal; Manish K. Aghi; Maria Agnello; Patrizia Agostinis; Patricia V. Aguilar; Julio Aguirre-Ghiso; Edoardo M. Airoldi; Slimane Ait-Si-Ali; Takahiko Akematsu; Emmanuel T. Akporiaye; Mohamed Al-Rubeai; Guillermo M. Albaiceta; Chris Albanese; Diego Albani; Matthew Albert; Jesus Aldudo; Hana Algül; Mehrdad Alirezaei; Iraide Alloza; Alexandru Almasan; Maylin Almonte-Beceril; Alnemri; Covadonga Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Silvia Alvarez; Lydia Alvarez-Erviti; Sandro Alves; Giuseppina Amadoro; Atsuo Amano; Consuelo Amantini; Santiago Ambrosio; Ivano Amelio; Amal O. Amer; Mohamed Amessou; Angelika Amon; Zhenyi An; Frank A. Anania; Stig U. Andersen; Usha P. Andley; Catherine K. Andreadi; Nathalie Andrieu-Abadie; Alberto Anel; David K. Ann; Shailendra Anoopkumar-

Understanding Crohn's disease through genetics

Cell Cycle, ISSN: 15514005

Aditya Murthy; Menno van Lookeren Campagne

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A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

Nature, ISSN: 00280836

Aditya Murthy; Yun Li; Ivan Peng; Mike Reichelt; Anand Kumar Katakam; Raj Noubade; Meron Roose-Girma; Jason DeVoss; Lauri Diehl; Rob Graham; Menno van Lookeren Campagne

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University of Toronto, Ph.D., Department of Medical Biophysics – 2011
University of Toronto, Hon. B.Sc., Human Biology – 2005

Frederick Banting & Charles Best Canada Graduate Scholarship for doctoral research – 2009
Doctoral thesis nominated for Canada Governor General’s Gold Medal – 1999

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Aditya Murthy

Scientist, Cancer Immunology

Featured Publication