"I am thrilled to be part of a research community that strives to transform fundamentally important scientific discoveries into novel therapies."
The advent of genome-wide association studies (GWAS) has enabled true forward-genetics based investigations of devastating yet genetically complex chronic inflammatory diseases. I joined Genentech as a post-doctoral fellow in 2011 to investigate the contribution of host genetics on inflammatory bowel disease using GWAS as a starting point. As a postdoc, I witnessed how world-class scientific expertise across disciplines could collaborate to drive rapid progress in our understanding of human immunology, from genetic associations to functional molecular mechanisms. I was excited for the opportunity to translate these learnings into a new avenue of study, when I started my own research program in Cancer Immunology in 2014.
Currently, my group investigates GWAS-based immuno-regulatory pathways in cancer immunology. We aim to exploit the insights gained from human genetics of inflammatory diseases towards therapeutic avenues that engender anti-tumor immunity.
Cell Death Differ. 2018 May;25(5):825-827.
Nature. 2014 Feb 27;506(7489):456-62.
My research program currently has 3 focus areas: