Ali Zarrin - Senior Scientist, Immunology

Ali Zarrin

Senior Scientist, Immunology

Postdoc Mentor
"Genentech thrives on cutting edge science and innovations to advance drug discovery research. It offers me intellectual challenge, curious excitement, and an opportunity to be of service to patients in an effectively scientific environment."
Years at Genentech
Awards & Honors

I finished my Ph.D. in immunology at the University of Toronto and joined Fred Alt’s group at Harvard University to complete my postdoctoral research. I joined the Immunology Discovery group at Genentech in the summer of 2007, thus fulfilling my passion for drug discovery research. I am certainly proud of this decision, as I have been able to extend and diversify my expertise in various autoimmune and inflammatory disease areas, allowing me to gain in-depth knowledge about relevant cellular and molecular pathways.

Postdoctoral Mentor

The postdoctoral program at Genentech offers a great opportunity to profoundly advance a scientific area especially in the context of human disease. A collaborative environment, exposure to the best scientific seminars on a regular basis and a tremendous support from various functions enables rapid progress which is hard to match elsewhere.

Featured Publication

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Sci Signal. 2017 Apr 18;10(475).

Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Science Signaling, 2015, 8(405), 1-12.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie B, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.