Scientists / Our Scientists

Arvind Rajpal

VP LM Drug Discovery - Antibody Engineering & Protein Chemistry, Large Molecule Drug Discovery

Postdoc Mentor

"I aspire to innovate at the interface between biology and technology with the hope to address unmet medical needs."

Years at Genentech

Publications at Genentech

I joined Genentech in 2020 as Vice President, Large Molecule Drug Discovery. I was attracted to Genentech because of its reputation, scientific rigor, and rich legacy in large molecule drug discovery and development.

The large molecule discovery team collaborates with therapeutic area biology, functional, and early development teams to establish and progress a potentially impactful therapeutics portfolio.

Featured Publication

VISTA Is an Acidic pH-selective Ligand for PSGL-1.

Nature. 2019 Oct;574(7779):565- 570. doi: 10.1038/s41586-019-1674-5.

Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L, Martin GH, Lemar H, Cayton T, Huang RY, Deng X, Nayeem A, Chen H, Ergel B, Rizzo JM, Yamniuk AP, Dutta S, Ngo J, Shorts AO, Ramakrishnan R, Kozhich A, Holloway J, Fang H, Wang YK, Yang Z, Thiam K, Rakestraw G, Rajpal A, Sheppard P, Quigley M, Bahjat KS, Korman AJ.

View Abstract

My research is focussed on using protein engineering to modulate biological mechanisms of diseases. In the past, it has included site-specifically conjugated ADCs, bispecific IgG, and cell therapies in oncology; conditionally activated molecules in cancer immunology and metabolic diseases; patient derived neutralizing antibodies against infectious pathogens; and directed evolution of alternative scaffolds in neuroscience.

Designing antibodies as therapeutics

Cell, ISSN: 10974172 00928674

Paul J. Carter; Arvind Rajpal

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Engineering highly potent and selective microproteins against Nav1.7 sodium channel for treatment of pain

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Anatoly Shcherbatko; Andrea Rossi; Davide Foletti; Guoyun Zhu; Oren Bogin; Meritxell Galindo Casas; Mathias Rickert; Adela Hasa-Moreno; Victor Bartsevich; Andreas Crameri; Alexander R. Steiner; Robert A. Henningsen; Avinash Gill; Jaume Pons; David L. Shelton; Arvind Rajpal; Pavel Strop

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Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing

Journal of Molecular Biology, ISSN: 10898638 00222836

Thomas Van Blarcom; Andrea Rossi; Davide Foletti; Purnima Sundar; Steven Pitts; Christine Bee; Jody Melton Witt; Zea Melton; Adela Hasa-Moreno; Lee Shaughnessy; Dilduz Telman; Lora Zhao; Wai Ling Cheung; Jan Berka; Wenwu Zhai; Pavel Strop; Javier Chaparro-Riggers; David L. Shelton; Jaume Pons; Arvind Rajpal

View on Scopus

Degrees University of California at Berkeley, College of Chemistry, Ph.D. – 1998
Knox College, Departments of Chemistry and Computer Science, B.A. – 1992

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Arvind Rajpal

VP LM Drug Discovery - Antibody Engineering & Protein Chemistry, Large Molecule Drug Discovery

Featured Publication

VISTA Is an Acidic pH-selective Ligand for PSGL-1.