Brad Snedecor
Distinguished Engineer, Cell Culture and Bioprocess Operations
Fellow
41
Years at Genentech
46
Publications at Genentech
2
Awards & Honors
I came to Genentech in 1981 from MIT as a newly minted Biochemical Engineer and was hired as a Scientist to help establish the Biocatalysis Department then in Research, and in 1987 joined Medicinal and Biomolecular Chemistry. In 1988 I moved into Fermentation R&D, developing the initial process technology for antibody fragment expression in E. coli, and from 1994 led the E. coli fermentation development labs for the next decade. Since that time I have focused on mammalian cell culture technology development, and for 12 years led a Cell Culture group in Pharma Technical Development that works to develop mammalian manufacturing cell lines and to improve cell line development, during the development of targeted integration, 1-cell bispecific antibody cell lines, pool-for-tox timeline acceleration, single cell lines for tox through production, and timeline acceleration from serum free cell line development. Titers went from 1 g/L to > 10 g/L over this period. Since 2018 I've served as a technical expert for this and other groups in Cell Culture.
Pharma Technical Development bridges Research to Manufacturing, and I enjoy tremendously the opportunity to engage the diverse problems that entails, working with ingenious people across the company.
Featured Publication
Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production.
Biotechnology Progress, ISSN: 87567938
Shahram Misaghi; Yan Qu; Andrew Snowden; Jennifer Chang; Brad Snedecor
My Focus
I work with others to understand the underlying processes at work in our production processes and our process development to guide the improvement of both, and search across biology for new understandings and tools we can apply for the same purposes.
Genentech Publications
Journal of the American Chemical Society, ISSN: 15205126 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Cynthia Lam; Niels Bauer; Simon Auslaender; Snedecor; Mike Laird; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Jane Gunson; Eric Tran; Cynthia Lam; Amy Shen; Snedecor; Gavin Barnard; Shahram Misaghi
Biotechnology Progress, ISSN: 87567938
Danming Tang; Jane Gunson; Eric Tran; Cynthia Lam; Amy Shen; Snedecor; Gavin Barnard; Shahram Misaghi
Journal of the American Chemical Society, ISSN: 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Wendy N. Sandoval; Peter S. Liu; Cynthia Lam; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Domingos Ng; Meixia Zhou; Dejin Zhan; Shirley S. M. Yip; Peggy Ko; Mandy Yim; Zora Modrusan; John C. Joly; Snedecor; Mike Laird; Amy Shen
Biotechnology Journal, ISSN: 18607314 18606768
Emily Dong; Cynthia Lam; Danming Tang; Salina Louie; Mandy Yim; Ambrose Jon Williams; William S. Sawyer; Shirley S. M. Yip; Joe Carver; Ali AlBarakat; Joni Tsukuda; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Cynthia Lam; Niels Bauer; Simon Auslaender; Snedecor; Mike Laird; Shahram Misaghi
Journal of Biotechnology, ISSN: 18734863 01681656
Salina Louie; Jayanthi Lakkyreddy; Brian M. Castellano; Benjamin Haley; Anh Nguyen Dang; Cynthia Lam; Danming Tang; Steven E. Lang; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Joe Carver; Domingos Ng; Michelle Zhou; Peggy Ko; Dejin Zhan; Mandy Yim; David Shaw; Snedecor; Mike Laird; Steven E. Lang; Amy Shen; Zhilan Hu
Journal of Cell Biology, ISSN: 15408140 00219525
Danming Tang; Wendy N. Sandoval; Cynthia Lam; Benjamin Haley; Peter S. Liu; Di Xue; Deepankar Roy; Thomas W. Patapoff; Salina Louie; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Salina Louie; Amy Heidersbach; Noelia Blanco; Benjamin Haley; Christopher M. Rose; Peter S. Liu; Mandy Yim; Danming Tang; Cynthia Lam; Wendy N. Sandoval; David Shaw; Snedecor; Shahram Misaghi
Biotechnology Journal, ISSN: 18607314 18606768
Danming Tang; Jayashree Subramanian; Benjamin Haley; Jordan Baker; Lucas Luo; Wendy Hsu; Peter S. Liu; Wendy N. Sandoval; Mike Laird; Snedecor; Masaru Shiratori; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Tomofumi Tadauchi; Cynthia Lam; Laura Liu; Yizhou Zhou; Danming Tang; Salina Louie; Snedecor; Shahram Misaghi
Biotechnology Journal, ISSN: 18607314 18606768
Meg Tung; Danming Tang; Szu-Han Wang; Dejin Zhan; Karen Kiplinger; Shu Pan; Yifeng Jing; Amy Shen; Patrick Ahyow; Snedecor; Martin Gawlitzek; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Peggy Ko; Shahram Misaghi; Zhilan Hu; Dejin Zhan; Joni Tsukuda; Mandy Yim; Mark Sanford; David Shaw; Masaru Shiratori; Snedecor; Mike Laird; Amy Shen
Biotechnology Progress, ISSN: 15206033 87567938
David Shaw; Mandy Yim; Joni Tsukuda; John C. Joly; Andy Lin; Snedecor; Mike Laird; Steven E. Lang
Biotechnology Progress, ISSN: 15206033 87567938
Yizhou Zhou; David Shaw; Cynthia Lam; Joni Tsukuda; Mandy Yim; Danming Tang; Salina Louie; Mike Laird; Snedecor; Shahram Misaghi
Biotechnology Journal, ISSN: 18607314 18606768
Danming Tang; Cynthia Lam; Salina Louie; Kam Hon Hoi; David Shaw; Mandy Yim; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Wei-Ting Hsu; Abigail F.J. Pynn; Domingos Ng; Donna Quicho; Yilma T. Adem; Zephie Kwong; Brad Mauger; John C. Joly; Snedecor; Mike Laird; Dana C. Andersen; Amy Shen
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Danming Tang; Shahram Misaghi; Guoying Jiang; X. Christopher Yu; Mandy Yim; David Shaw; Snedecor; Mike Laird; Amy Shen
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Salina Louie; Benjamin Haley; Brett Marshall; Amy Heidersbach; Mandy Yim; Martina Brozynski; Danming Tang; Cynthia Lam; Bronislawa Petryniak; David Shaw; Jeongsup Shim; Aaron S. Miller; John Lowe; Snedecor; Shahram Misaghi
Biotechnology Progress, ISSN: 15206033 87567938
Cynthia Lam; Santell; Blair Wilson; Mandy Yim; Salina Louie; Danming Tang; David Shaw; Pamela Chan; Lazarus; Snedecor; Shahram Misaghi
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Zhilan Hu; Henry Zhang; Benjamin Haley; Frank D. Macchi; Feng Yang; Shahram Misaghi; Joseph Elich; Renee Yang; Yun Tang; John C. Joly; Snedecor; Amy Shen
Biotechnology Progress, ISSN: 15206033 87567938
Shahram Misaghi; David Shaw; Salina Louie; Adrian Nava; Laura C. Simmons; Snedecor; Chungkee Poon; Jonathan S. Paw; Laurie L. Gilmour; James Cupp
Biotechnology and Bioengineering, ISSN: 10970290
Zhilan Hu; Henry Zhang; Benjamin Haley; Frank D. Macchi; Feng Yang; Shahram Misaghi; Joseph Elich; Renee Yang; Yun Tang; John C. Joly; Snedecor; Amy Shen
Biotechnology Progress, ISSN: 15206033 87567938
Shahram Misaghi; Chang; Snedecor
Molecular Biotechnology, ISSN: 15590305 10736085
Shirley S. M. Yip; Meixia Zhou; John C. Joly; Snedecor; Amy Shen; Yongping Crawford
Biotechnology Progress, ISSN: 87567938 15206033
Yongping Crawford; Michelle Zhou; Zhilan Hu; John C. Joly; Snedecor; Amy Shen; Albert Gao
Biotechnology Progress, ISSN: 87567938 15206033
Zhilan Hu; Donglin Guo; Shirley S. M. Yip; Dejin Zhan; Shahram Misaghi; John C. Joly; Snedecor; Amy Shen
Biotechnology Progress, ISSN: 87567938 15206033
Shahram Misaghi; Yan Qu; Andrew Snowden; Chang; Snedecor
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Inn H. Yuk; Boyan Zhang; Yi Yang; George Dutina; Kimberly D. Leach; Natarajan Vijayasankaran; Amy Shen; Dana C. Andersen; Snedecor; John C. Joly
Journal of Biotechnology, ISSN: 01681656
Meixia Zhou; Yongping Crawford; Domingos Ng; Jack Tung; Abigail F.J. Pynn; Angela Meier; Inn H. Yuk; Natarajan Vijayasankaran; Kimberly D. Leach; John C. Joly; Snedecor; Amy Shen
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Donglin Guo; Albert Gao; David A. Michels; Lauren Feeney; Eng; Betty Chan; Mike Laird; Boyan Zhang; X. Christopher Yu; John C. Joly; Snedecor; Amy Shen
Metabolic Engineering, ISSN: 10967176 10967184
Adam L. Meadows; Rahi Karnik; Harry Lam; Sean Forestell; Snedecor
Biotechnology and Bioengineering, ISSN: 00063592
Christina Y. Chen; Snedecor; Julie C. Nishihara; John C. Joly; Nancy McFarland; Dana C. Andersen; John E. Battersby; Kathleen M. Champion
Cytokine, ISSN: 10434666
Leong; Laura DeForge; Presta; Gonzalez; Audrey Fan; Marcel Reichert; Anan Chuntharapai; Jin Kim; Daniel B. Tumas; Wyne P. Lee; Gribling; Snedecor; Han Chen; Vanessa Hsei; Schoenhoff; Victoria Hale; James Deveney; Iphigenia Koumenis; Shahrokh; McKay; Walter Galan; Brian Wagner; Narindray; Hébert; Gerardo Zapata
Biotechnology and Bioengineering, ISSN: 00063592
Dana C. Andersen; James R. Swartz; Thomas Ryll; Lin; Snedecor
Journal of Chromatography A, ISSN: 00219673
John E. Battersby; Snedecor; Christina Y. Chen; Kathleen M. Champion; Riddle; Vanderlaan
Bio/Technology, ISSN: 0733222X
Zhu; Gerardo Zapata; Shalaby; Snedecor; Man Chert; Paul J. Carter
Journal of Immunology, ISSN: 00221767
Maria L. Rodrigues; Snedecor; Christina Y. Chen; Wai Lee T. Wong; Shaily Garg; Gregory S. Blank; Daniel A. Maneval; Paul J. Carter
Biochemistry, ISSN: 15204995 00062960
Robert F. Kelley; Mark P. O'Connell; Paul J. Carter; Presta; Eigenbrot; Michael Covarrubias; Snedecor; James H. Bourell; David Vetterlein
Bio/Technology, ISSN: 0733222X
Paul J. Carter; Robert F. Kelley; Maria L. Rodrigues; Snedecor; Michael Covarrubias; Mark Velligan; Wai T. Wong Lee; Rowland; Claire Kotts; Monique E. Carver; Yang; James H. Bourell; Michael Shepard; Henner
Journal of Bacteriology, ISSN: 00219193
Snedecor; Chu; Ellson Y. Chen
Org Chem from Biomass,
Snedecor; Gomez
Education
- Massachusetts Institute of Technology, Ph.D in Biochemical Engineering with a minor in Molecular Biology – 1981
- Massachusetts Institute of Technology, M.S in Biochemcal Engineering – 1977
- Massachusetts Institute of Technology, B.S. in Chemistry – 1975
Awards & Honors
- National Science Foundation Graduate Fellow – 1976-1979
- National Merit Scholar – 1971-1975