Genentech: Brent McKenzie | Senior Director, Translational Immunology

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Scientists / Our Scientists

"In gRED we share a passion to translate the biggest scientific advances of today into the best possible drugs of tomorrow."

Years at Genentech

Publications

Awards & Honors

I joined gRED in 2014 to lead the Translational Immunology department and find the research environment at Genentech incredibly rewarding. I enjoy the challenge of working across multiple areas of unmet medical need alongside some of the best and brightest scientists. I was drawn to industry research early in my career through a fruitful collaboration as a PhD student in the Autoimmunity and Transplantation department at the Walter and Eliza Hall Institute (WEHI). After a postdoc I moved from WEHI to DNAX in Palo Alto California (now Merck) to further my experience in early stage drug discovery. There we performed pioneering work on cytokine and T cell biology that underpins several new drug targets still being pursued today. I then joined CSL ltd in Parkville Australia where I continued to employ numerous in-vivo models to understand cellular and subcellular mechanisms of Autoimmunity, Inflammation, Fibrosis, Coagulation, Cancer, Metabolism & Vaccine responses.

Featured Publication

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

Cell Death Differ. 2016 Sep 1;23(9):1565-76.

Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.

View Abstract

Here in the Translational Immunology Department we use cutting edge methods and technologies to understand how molecular and cellular pathways contribute to disease pathogenesis in inflammatory, fibrotic, infectious and ocular diseases. We use in-vivo modeling to test new hypotheses, evaluate efficacy, understand drug safety and benchmark new therapies. We work on both early as well as late stage drug targets throughout our small and large molecule portfolio and enjoy collaborations with almost every other department here in gRED.

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

Science Signaling, ISSN: 19379145

Alex Corzo; Eugene Varfolomeev; Francesca Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeff Eastham; Arna Katewa; Jodie Pang; Melanie Domeyer; Chris Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans Brightbill; Soren Warming; Meron Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James Crawford; Wendy Young; Rajita Pappu; Brent McKenzie; Vida Asghari; Domagoj Vucic; Jason Hackney; Cary Austin; Wyne Lee; Annemarie Lekkerkerker; Nico Ghilardi; Callie Bryan; James Kiefer; Michael Townsend; Ali Zarrin

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Brent McKenzie

Senior Director, Translational Immunology

Featured Publication

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.