Brent McKenzie
Senior Director Translational Immunology, Translational Immunology
"In gRED we share a passion to translate the biggest scientific advances of today into the best possible drugs of tomorrow."
7
Years at Genentech
26
Publications
3
Awards & Honors
I joined gRED in 2014 to lead the Translational Immunology department and find the research environment at Genentech incredibly rewarding. I enjoy the challenge of working across multiple areas of unmet medical need alongside some of the best and brightest scientists. I was drawn to industry research early in my career through a fruitful collaboration as a PhD student in the Autoimmunity and Transplantation department at the Walter and Eliza Hall Institute (WEHI). After a postdoc I moved from WEHI to DNAX in Palo Alto California (now Merck) to further my experience in early stage drug discovery. There we performed pioneering work on cytokine and T cell biology that underpins several new drug targets still being pursued today. I then joined CSL ltd in Parkville Australia where I continued to employ numerous in-vivo models to understand cellular and subcellular mechanisms of Autoimmunity, Inflammation, Fibrosis, Coagulation, Cancer, Metabolism & Vaccine responses.
Featured Publication
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
Cell Death Differ. 2016 Sep 1;23(9):1565-76.
Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.
My Focus
Here in the Translational Immunology Department we use cutting edge methods and technologies to understand how molecular and cellular pathways contribute to disease pathogenesis in inflammatory, fibrotic, infectious and ocular diseases. We use in-vivo modeling to test new hypotheses, evaluate efficacy, understand drug safety and benchmark new therapies. We work on both early as well as late stage drug targets throughout our small and large molecule portfolio and enjoy collaborations with almost every other department here in gRED.
Publications
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury
Cell Death and Disease,
Kimberly Stark; Tanya Goncharov; Eugene Varfolomeev; Luke Xie; Hai Ngu; Ivan Peng; Keith Anderson; Erik Verschueren; Meena Choi; Donald S. Kirkpatrick; Amy Easton; Webster; Brent McKenzie; Domagoj Vucic; Baris Bingol
NINJ1 mediates plasma membrane rupture during lytic cell death
Nature, ISSN: 00280836
Nobuhiko Kayagaki; Opher S. Kornfeld; Bettina L. Lee; Irma Stowe; Karen O’Rourke; Qingling Li; Wendy Sandoval; Donghong Yan; Jing Kang; Min Xu; Juan Zhang; Wyne P. Lee; Brent McKenzie; Gözde Ulas; Jian Payandeh; Meron Roose-Girma; Zora Modrusan; Rohit Reja; Meredith Sagolla; Joshua D. Webster; Vicky Cho; T. Daniel Andrews; Lucy X. Morris; Lisa A. Miosge; Christopher C. Goodnow; Edward M. Bertram; Vishva Dixit
Science Signaling, ISSN: 19379145
Alex Corzo; Eugene Varfolomeev; Francesca Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeff Eastham; Arna Katewa; Jodie Pang; Melanie Domeyer; Chris Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans Brightbill; Soren Warming; Meron Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James Crawford; Wendy Young; Rajita Pappu; Brent McKenzie; Vida Asghari; Domagoj Vucic; Jason Hackney; Cary Austin; Wyne Lee; Annemarie Lekkerkerker; Nico Ghilardi; Callie Bryan; James Kiefer; Michael Townsend; Ali Zarrin
CD96 functions as a co-stimulatory receptor to enhance CD8+ T cell activation and effector responses
European Journal of Immunology, ISSN: 15214141 00142980
Eugene Chiang; Patricia De Almeida; Denise De Almeida Nagata; Kristin Harden Bowles; Xiangnan Du; Avantika S. Chitre; Karl L. Banta; Youngsu Kwon; Brent McKenzie; Stephanie Mittman; Rafael Cubas; Keith Anderson; Soren Warming; Jane Grogan
Science Signaling, ISSN: 19379145 19450877
Alex Corzo; Eugene Varfolomeev; Francesca Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeff Eastham; Arna Katewa; Jodie Pang; Melanie Domeyer; Christopher Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans Brightbill; Soren Warming; Meron Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James Crawford; Wendy Young; Rajita Pappu; Brent McKenzie; Vida Asghari; Domagoj Vucic; Jason Hackney; Cary Austin; Wyne P. Lee; Annemarie Lekkerkerker; Nico Ghilardi; Callie Bryan; James Kiefer; Michael Townsend; Ali Zarrin
RIP1 kinase activity is critical for skin inflammation but not for viral propagation
Journal of Leukocyte Biology, ISSN: 07415400
Webster; Youngsu Kwon; Summer Park; Hua Zhang; Nick Corr; Nina Ljumanovic; Adeyemi O. Adedeji; Eugene Varfolomeev; Tanya Goncharov; Jessica Preston; Sara F. Santagostino; Snahel Patel; Min Xu; Jonathan M. Maher; Brent McKenzie; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Alexander D. Gitlin; Klaus Heger; Alexander F Schubert; Rohit Reja; Donghong Yan; Victoria Pham; Eric Suto; Juan Zhang; Youngsu C. Kwon; Emily C. Freund; Jing Kang; Anna Pham; Roger Caothien; Natasha Bacarro; Trent Hinkle; Min Xu; Brent McKenzie; Benjamin Haley; Wyne P. Lee; Jennie Lill; Meron Roose-Girma; Monika Dohse; Webster; Kim Newton; Vishva Dixit
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Meron Roose-Girma; Min Xu; Brent McKenzie; Menno van Lookeren Campagne; Kim Newton; Aditya Murthy
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623
Callie Bryan; Joy Drobnick; Alberto Gobbi; Aleksandr Kolesnikov; Yongsheng Chen; Naomi S. Rajapaksa; Chudi Ndubaku; Jianwen Feng; Willy Chang; Ross Francis; Christine Yu; Edna Choo; Kevin DeMent; Yingqing Ran; Le An; Claire Emson; Zhiyu Huang; Swathi Sujatha-Bhaskar; Hans Brightbill; Antonio DiPasquale; Jonathan M. Maher; John Wai; Brent McKenzie; Patrick Lupardus; Ali Zarrin; James Kiefer
ACS Medicinal Chemistry Letters, ISSN: 19485875
Naomi S. Rajapaksa; Alberto Gobbi; Joy Drobnick; Steven Do; Aleksandr Kolesnikov; Jun Liang; Yongsheng Chen; Swathi Sujatha-Bhaskar; Zhiyu Huang; Hans Brightbill; Ross Francis; Christine Yu; Edna Choo; Kevin DeMent; Yingqing Ran; Le An; Claire Emson; Jonathan M. Maher; John Wai; Brent McKenzie; Patrick Lupardus; Ali Zarrin; James Kiefer; Callie Bryan
American Journal of Physiology - Renal Physiology, ISSN: 15221466 03636127
Luke Xie; Georgios Koukos; Kai Barck; Oded Foreman; Wyne P. Lee; Bob Brendza; Jeff Eastham; Brent S. McKenzie; Andy Peterson; Rick Carano
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Cell Death and Differentiation, ISSN: 13509047
Snahel Patel; Webster; Eugene Varfolomeev; Youngsu Kwon; Jason Cheng; Juan Zhang; Debbie Dugger; Kate Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreema Ramaswamy; Gauri Deshmukh; Bianca Liederer; Rina Fong; Gregory L. Hamilton; Patrick Lupardus; Patrick Caplazi; Wyne P. Lee; Menno van Lookeren Campagne; Adam Johnson; Brent McKenzie; Melissa Junttila; Kim Newton; Domagoj Vucic
Nature Communications, ISSN: 20411723
Hans Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette Castanedo; Benjamin T. Jackson; Youngsu Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leo Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael Townsend; Jason DeVoss; Adam Johnson; Robert Godemann; Wyne Lee; Cary Austin; Brent McKenzie; Jason Hackney; James J. Crawford; Steven Staben; Moulay Hicham Alaoui-Ismaili; Lawren Wu; Nico Ghilardi
Scientific Reports, ISSN: 20452322
Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne
Erratum to: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy (Scientific Reports, (2018), 8, 1, (7348), 10.1038/s41598-018-25557-8)
Scientific Reports,
Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne P. Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma
Science Translational Medicine,
Hart S. Dengler; Xiumin Wu; Ivan Peng; Cornelia H. Rinderknecht; Youngsu Kwon; Eric Suto; Pawan Bir Kohli; Marya Liimatta; Kathy Barrett; Julia Lloyd; Gary Cain; Mike Briggs; Stephanie Addo; Gary Salmon; Savita Ubhayakar; Gauri Deshmukh; Sheerin Latham; Cristine M. Quiason-Huynh; Janet Jackman; John Liu; Nicholas C. Ray; Simon Goodacre; Adam Johnson; Brent McKenzie; Wyne P. Lee; Mark Zak; Jane Kenny; Nico Ghilardi
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette Castanedo; Jason Burch; Leo Berezhkovskiy; Hans Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter Fan; Jianwen Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent McKenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren Wu; Yamin Zhang; Zoe Zhong; Steven Staben
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
Journal of Medicinal Chemistry, ISSN: 00222623
James J. Crawford; Adam Johnson; Misner; Lisa Belmont; Georgette Castanedo; Regina Choy; Melis Coraggio; Liming Dong; Charles Eigenbrot; Rebecca Erickson; Nico Ghilardi; Jonathan Hau; Arna Katewa; Pawan Bir Kohli; Wendy Lee; Joe Lubach; Brent McKenzie; Dan Ortwine; Leah Schutt; Suzanne Brown; Binqing Wei; Karin Reif; Lichuan Liu; Harvey Wong; Wendy Young
Pharmacological Research, ISSN: 10961186 10436618
Daqi Xu; Marissa L. Matsumoto; Brent McKenzie; Ali Zarrin
Nature Immunology, ISSN: 15292916 15292908
Mohammad Samie; Junghyun Lim; Erik Verschueren; Joshua Baughman; Ivan Peng; Aaron Wong; Youngsu Kwon; Yasin Senbabaoglu; Jason Hackney; Mary Keir; Brent McKenzie; Don Kirkpatrick; Menno van Lookeren Campagne; Aditya Murthy
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
eLife,
Alexandra M. Whiteley; Miguel A. Prado; Ivan Peng; Alexander Abbas; Benjamin Haley; Joao A. Paulo; Mike Reichelt; Anand Kumar Katakam; Meredith Sagolla; Zora Modrusan; Dong Yun Lee; Meron Roose-Girma; Don Kirkpatrick; Brent McKenzie; Steven P. Gygi; Daniel Finley; Eric Brown
Science Signaling, ISSN: 19379145
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Neko Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
Cell Death and Differentiation, ISSN: 14765403
Kim Newton; Debbie Dugger; Maltzman; Joan Greve; Maj Hedehus; Baby Martin-Mcnulty; Rick Carano; Cao; Nick Van Bruggen; Bernstein; Wyne Lee; Xiumin Wu; Jason DeVoss; Zhang; Surinder Jeet; Peng; Brent McKenzie; Meron Roose-Girma; Patrick Caplazi; Lauri Diehl; Webster; Vucic
Science Signaling, ISSN: 19379145
Yonglian Sun; Ivan Peng; Joshua Webster; Eric Suto; Justin Lesch; Xiumin Wu; Kate Senger; George Francis; Kathy Barrett; Jenna Collier; Jason Burch; Meijuan Zhou; Yuan Chen; Connie Chan; Jeff Eastham Anderson; Hai Ngu; Olga Li; Tracy Staton; Charles Havnar; Allan Jaochico; Janet Jackman; Surinder Jeet; Lorena Riol Blanco; Lawren Wu; David Choy; Joe Arron; Brent McKenzie; Nico Ghilardi; Moulay Hicham Alaoui Ismaili; Zhonghua Pei; Jason DeVoss; Cary Austin; Wyne Lee; Ali Zarrin
Journal of Clinical Investigation, ISSN: 00219738
David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent Mckenzie; Melanie A. Kleinschek; Alexander M. Owyang; Jeanine Mattson; Wendy M. Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J. Cua; Robert A Kastelein; Donna Rennick
Education
- WEHI, PhD in Medical Biology – 2003
- University of Melbourne, BSc. Hons. – 1998
Awards & Honors
- Australian Postgraduate Award –
- Hajime Research Award –
- University of Melbourne Honorable Appointment –