Genentech: Brent McKenzie | Associate Director , Translational Immunology

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Scientists / Our Scientists

"In gRED we share a passion to translate the biggest scientific advances of today into the best possible drugs of tomorrow."

Years at Genentech

Publications

Awards & Honors

I joined gRED in 2014 to lead the Translational Immunology department and find the research environment at Genentech incredibly rewarding. I enjoy the challenge of working across multiple areas of unmet medical need alongside some of the best and brightest scientists. I was drawn to industry research early in my career through a fruitful collaboration as a PhD student in the Autoimmunity and Transplantation department at the Walter and Eliza Hall Institute (WEHI). After a postdoc I moved from WEHI to DNAX in Palo Alto California (now Merck) to further my experience in early stage drug discovery. There we performed pioneering work on cytokine and T cell biology that underpins several new drug targets still being pursued today. I then joined CSL ltd in Parkville Australia where I continued to employ numerous in-vivo models to understand cellular and subcellular mechanisms of Autoimmunity, Inflammation, Fibrosis, Coagulation, Cancer, Metabolism & Vaccine responses.

Featured Publication

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

Cell Death Differ. 2016 Sep 1;23(9):1565-76.

Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.

View Abstract

Here in the Translational Immunology Department we use cutting edge methods and technologies to understand how molecular and cellular pathways contribute to disease pathogenesis in inflammatory, fibrotic, infectious and ocular diseases. We use in-vivo modeling to test new hypotheses, evaluate efficacy, understand drug safety and benchmark new therapies. We work on both early as well as late stage drug targets throughout our small and large molecule portfolio and enjoy collaborations with almost every other department here in gRED.

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Cell Death and Differentiation, ISSN: 14765403

Kim Newton; Debbie Dugger; Maltzman; Joan Greve; Maj Hedehus; Baby Martin-Mcnulty; Rick Carano; Cao; Nick Van Bruggen; Bernstein; Wyne Lee; Xiumin Wu; Jason DeVoss; Zhang; Surinder Jeet; Peng; Brent McKenzie; Meron Roose-Girma; Patrick Caplazi; Lauri Diehl; Webster; Vucic

View on Scopus

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Science Signaling, ISSN: 19379145

Yonglian Sun; Ivan Peng; Joshua Webster; Eric Suto; Justin Lesch; Xiumin Wu; Kate Senger; George Francis; Kathy Barrett; Jenna Collier; Jason Burch; Meijuan Zhou; Yuan Chen; Connie Chan; Jeff Eastham Anderson; Hai Ngu; Olga Li; Tracy Staton; Charles Havnar; Allan Jaochico; Janet Jackman; Surinder Jeet; Lorena Riol Blanco; Lawren Wu; David Choy; Joe Arron; Brent McKenzie; Nico Ghilardi; Moulay Hicham Alaoui Ismaili; Zhonghua Pei; Jason DeVoss; Cary Austin; Wyne Lee; Ali Zarrin

View on Scopus

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Science Signaling, ISSN: 19450877

Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Science Signaling, ISSN: 19379145

Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Neko Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin

View on Scopus

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

Journal of Clinical Investigation, ISSN: 00219738

David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent Mckenzie; Melanie A. Kleinschek; Alexander M. Owyang; Jeanine Mattson; Wendy M. Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J. Cua; Robert A Kastelein; Donna Rennick

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Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

eLife,

Alexandra M. Whiteley; Miguel A. Prado; Ivan Peng; Alexander Abbas; Benjamin Haley; Joao A. Paulo; Mike Reichelt; Anand Kumar Katakam; Meredith Sagolla; Zora Modrusan; Dong Yun Lee; Meron Roose-Girma; Don Kirkpatrick; Brent McKenzie; Steven P. Gygi; Daniel Finley; Eric Brown

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Nature Immunology, ISSN: 15292916 15292908

Mohammad Samie; Junghyun Lim; Erik Verschueren; Joshua Baughman; Ivan Peng; Aaron Wong; Youngsu Kwon; Yasin Senbabaoglu; Jason Hackney; Mary Keir; Brent McKenzie; Don Kirkpatrick; Menno van Lookeren Campagne; Aditya Murthy

View on Scopus

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Nature Communications, ISSN: 20411723

Hans Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette Castanedo; Benjamin T. Jackson; Youngsu Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leo Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael Townsend; Jason DeVoss; Adam Johnson; Robert Godemann; Wyne Lee; Cary Austin; Brent McKenzie; Jason Hackney; James J. Crawford; Steven Staben; Moulay Hicham Alaoui-Ismaili; Lawren Wu; Nico Ghilardi

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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Journal of Medicinal Chemistry, ISSN: 00222623

James J. Crawford; Adam Johnson; Misner; Lisa Belmont; Georgette Castanedo; Regina Choy; Melis Coraggio; Liming Dong; Charles Eigenbrot; Rebecca Erickson; Nico Ghilardi; Jonathan Hau; Arna Katewa; Pawan Bir Kohli; Wendy Lee; Joe Lubach; Brent McKenzie; Dan Ortwine; Leah Schutt; Suzanne Brown; Binqing Wei; Karin Reif; Lichuan Liu; Harvey Wong; Wendy Young

TPL2 kinase action and control of inflammation

Pharmacological Research, ISSN: 10961186 10436618

Daqi Xu; Marissa L. Matsumoto; Brent McKenzie; Ali Zarrin

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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

Scientific Reports, ISSN: 20452322

Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne

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Erratum to: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy (Scientific Reports, (2018), 8, 1, (7348), 10.1038/s41598-018-25557-8)

Scientific Reports,

Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne P. Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne

Scaffold-Hopping Approach to Discover Potent, Selective, and Efficacious Inhibitors of NF-Î°B Inducing Kinase

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Nicole Blaquiere; Georgette Castanedo; Jason Burch; Leo Berezhkovskiy; Hans Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter Fan; Jianwen Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent McKenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren Wu; Yamin Zhang; Zoe Zhong; Steven Staben

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Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Science Translational Medicine,

Hart S. Dengler; Xiumin Wu; Ivan Peng; Cornelia H. Rinderknecht; Youngsu Kwon; Eric Suto; Pawan Bir Kohli; Marya Liimatta; Kathy Barrett; Julia Lloyd; Gary Cain; Mike Briggs; Stephanie Addo; Gary Salmon; Savita Ubhayakar; Gauri Deshmukh; Sheerin Latham; Cristine M. Quiason-Huynh; Janet Jackman; John Liu; Nicholas C. Ray; Simon Goodacre; Adam Johnson; Brent McKenzie; Wyne P. Lee; Mark Zak; Jane Kenny; Nico Ghilardi

WEHI, PhD in Medical Biology – 2003
University of Melbourne, BSc. Hons. – 1998

University of Melbourne Honorable Appointment –
Hajime Research Award –
Australian Postgraduate Award –

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Brent McKenzie

Associate Director , Translational Immunology

Featured Publication

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.