David Arnott - Principal Scientist, Technology, Proteomics & Biological Resources

David Arnott

Principal Scientist, Technology, Proteomics & Biological Resources

"It has been a great privilege to work in a laboratory with equipment, co-workers, and research collaborations that would be the envy of most scientists in my field, and I’m deeply grateful for the opportunity to do basic research in the service of drug discovery."
Years at Genentech

I joined Genentech in 1994 as a postdoctoral fellow of John Stults in what was then the only large molecule mass spectrometry group in Research. As a graduate student I had used tandem mass spectrometry to sequence proteins and peptides, including those presented to the immune system by class-I molecules of the major histocompatibility complex in HIV-infected cells. At Genentech I helped establish the set of technologies that would become known as proteomics. Hired as a Scientist following my postdoc, I later became the group leader of the mass spectrometry lab and oversaw its growth from myself and 4 RAs to a Microchemistry and Proteomics Laboratory (MPL) of 14 members including Scientists, RAs, and post-docs. In 2010 I returned to the bench, and manage a small group within the MPL focused on epigenetics, targeted proteomics, and applications of mass spectrometry to protein structural analysis.

Featured Publication

Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method.

Mol Cell Proteomics. 2015 Apr;14(4):1148-58.

Maile TM, Izrael-Tomasevic A, Cheung T, Guler GD, Tindell C, Masselot A, Liang J, Zhao F, Trojer P, Classon M, Arnott D.