Gail Lewis Phillips - Senior Scientist, Translational Oncology

Gail Lewis Phillips

Senior Scientist, Translational Oncology

"As a translational research scientist, I have the exciting and rewarding position of directing a lab that bridges basic science discoveries with early drug development in Oncology."
34
Years at Genentech
43
Publications

I came to Genentech straight out of graduate school to join a lab working on anti-tumor cytokines (TNF-α and IFN-γ). We discovered that activated receptor tyrosine kinases, including HER2, were resistance mechanisms for TNF-α killing of tumor cells. These observations were coincident with the observation that overexpressed HER2 was oncogenic in preclinical models and was a poor prognostic marker in human breast cancer. We then focused our subsequent efforts on elucidating the biology of the HER2 pathway in breast cancer cells and on developing antibody-based therapeutics for HER2-positive cancers.

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