Genentech: Hans Erickson | Senior Scientist/ Director, Department of Protein Chemistry

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Scientists / Our Scientists

"It is an amazing privilege to work with such talented and creative researchers across Genentech to advance meaningful therapies for patients."

Years at Genentech

Publications

Awards & Honors

Motivated by Genentech’s focus on patients and scientific excellence, I joined the Department of Protein Chemistry in 2014 after working for eleven years developing antibody-drug conjugates at ImmunoGen.

The Department of Protein Chemistry utilizes recombinant protein and bioconjugation expertise to design and produce novel therapeutic candidates for the treatment of diseases with high unmet clinical need.

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My primary role is to direct the activities of the Department of Protein Chemistry. My research lab is focused on understanding the key biological mechanisms associated with our leading therapeutic candidates in Molecular Oncology. We collaborate closely with colleagues across the research community in this pursuit. Recently, we explored how the selection of the mutation sites impacts the stability of cysteine-engineered antibody-drug conjugates.

Our current interests are focused on deepening our mechanistic understanding of T cell-directed therapies using biochemical and biophysical approaches.

FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Byoung Chul Lee; Cecile Chalouni; Sophia Doll; Sam C. Nalle; Martine Darwish; Siao Ping Tsai; Kathy Kozak; Geoff Del Rosario; Shang-Fan Yu; Hans Erickson; Dick Vandlen

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High-Throughput Cysteine Scanning to Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Bioconjugate Chemistry, ISSN: 15204812 10431802

Rachana Ohri; Sunil Bhakta; Aimee Fourie-O'Donohue; Josefa Dela Cruz Chuh; Siao Ping Tsai; Ryan Cook; Binqing Wei; Carl Ng; Athena Wong; Aaron Bos; Farzam Farahi; Jiten Bhakta; Thomas Pillow; Helga Raab; Dick Vandlen; Paul Polakis; Yichin Liu; Hans Erickson; Jagath Reddy Junutula; Kathy Kozak

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Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Breanna S. Vollmar; Binqing Wei; Rachana Ohri; Jianhui Zhou; Jintang He; Shang-Fan Yu; Douglas Leipold; Ely Cosino; Sharon Yee; Aimee Fourie-O'Donohue; Ginny (Guangmin) Li; Gail Phillips; Kathy Kozak; Amrita Kamath; Keyang Xu; Genee Lee; Greg A. Lazar; Hans Erickson

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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Xiuxia Sun; Jose Ponte; Nicholas C. Yoder; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Qifeng Qiu; Rui Wu; E. Erica Hong; Megan Bogalhas; Lintao Wang; Ling Dong; Yulius Y. Setiady; Erin K. Maloney; Olga Ab; Xiaoyan Zhang; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert

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Antibody drug conjugates differentiate uptake and DNA alkylation of pyrrolobenzodiazepines in tumors from organs of xenograft mice

Drug Metabolism and Disposition, ISSN: 1521009X

Yong Ma; Cyrus Khojasteh; Marcel Hop; Hans Erickson; Andy Polson; Thomas Pillow; Shang-Fan Yu; Hong Wang; Peter Dragovich; Donglu Zhang

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Chemical structure and concentration of intratumor catabolites determine efficacy of antibody drug conjugates

Drug Metabolism and Disposition, ISSN: 1521009X

Donglu Zhang; Shang-Fan Yu; Yong Ma; Keyang Xu; Peter Dragovich; Thomas Pillow; Luna Liu; Geoff Del Rosario; Jintang He; Zhonghua Pei; Jack Sadowsky; Hans Erickson; Marcel Hop; Cyrus Khojasteh

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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Jose Ponte; Xiuxia Sun; Nicholas C. Yoder; Nathan Fishkin; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Megan Bogalhas; Lintao Wang; Sharon Wilhelm; Wayne C. Widdison; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert

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A new triglycyl peptide linker for antibody-drug conjugates (ADCs) with improved targeted killing of cancer cells

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Rajeeva Singh; Yulius Y. Setiady; Jose Ponte; Yelena Kovtun; Katharine C. Lai; E. Erica Hong; Nathan Fishkin; Ling Dong; Gregory Jones; Jennifer A. Coccia; Leanne Lanieri; Karen Veale; Juliet A. Costoplus; Anna Skaletskaya; Rabih Gabriel; Paulin Salomon; Rui Wu; Qifeng Qiu; Hans Erickson; John M. Lambert; Ravi Chari; Wayne C. Widdison

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Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates

mAbs, ISSN: 19420870

Kalli C. Catcott; Molly A. McShea; Carl Uli Bialucha; Kathy L. Miller; Stuart W. Hicks; Parmita Saxena; Thomas G. Gesner; Mikias Woldegiorgis; Megan E. Lewis; Chen Bai; Michael S. Fleming; Seth A. Ettenberg; Hans Erickson; Nicholas C. Yoder

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Design of coltuximab ravtansine, a CD19-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies: Structure-activity relationships and preclinical evaluation

Molecular Pharmaceutics, ISSN: 15438392

E. Erica Hong; Hans Erickson; Robert J. Lutz; Kathleen R. Whiteman; Gregory Jones; Yelena Kovtun; Veronique Blanc; John M. Lambert

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Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Russ Wada; Hans Erickson; Gail Phillips; Carmela A. Provenzano; Douglas Leipold; Elaine Mai; Holly A. Johnson; Jack (Jay) Tibbitts

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American Association of Pharmaceutical Scientists National Biotechnology Conference short course: Translational challenges in developing antibody-drug conjugates

mAbs, ISSN: 19420862

Karen Thudium; Sanela Bilic; Douglas Leipold; Bill Mallet; Surinder Kaur; Bernd Meibohm; Hans Erickson; Jack (Jay) Tibbitts; Hong Zhao; Manish Gupta

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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates

Molecular Cancer Therapeutics, ISSN: 15357163

Hans Erickson; Gail Phillips; Douglas Leipold; Carmela A. Provenzano; Elaine Mai; Holly A. Johnson; Bert Gunter; Charlene A. Audette; Manish Gupta; Jan Pinkas; Jack (Jay) Tibbitts

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University of California, San Diego , PhD – 1999
University of California, Santa Barbara, B.S. Chemistry – 1994

NIH Postdoctoral Fellow, University of Utah – 2000-2003

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Hans Erickson

Senior Scientist/ Director, Department of Protein Chemistry

Featured Publication