Genentech: Haochu Huang | Senior Principal Scientist, Translational Oncology

Scientists / Our Scientists

"Genentech’s commitment to basic biology and innovation is fundamental to novel drug development."

Years at Genentech

Publications at Genentech

Awards & Honors

I joined Genentech in 2016. Prior to Genentech, I was a faculty member at the University of Chicago studying immune tolerance and autoimmune disease. I was fascinated by tumor immunology as tumors represent a unique “self” to the immune system. The recent success of cancer immunotherapy has been revolutionizing the field, and I was thrilled to join Genentech to develop novel immunotherapies that could have direct impact on patients.

Featured Publication

Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.

Cell Rep. 2016 Oct 4;17(2):387-398.

Perera J, Zheng Z, Li S, Gudjonson H, Kalinina O, Benichou JIC, Block KE, Louzoun Y, Yin D, Chong AS, Dinner AR, Weigert M, Huang H.

View Abstract

My lab focuses on evaluating the efficacy, pharmacokinetics, pharmacodynamics, mechanism of action, and combinatorial therapeutic strategies of small molecules and biologics against select targets in cancer immunotherapy. We utilize and develop various mouse models of tumor immunology. We work closely with our discovery colleagues in Cancer Immunology to inform preclinical target validation and molecule selection.

PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution

Bioconjugate Chemistry, ISSN: 15204812 10431802

Breanna S. Vollmar; Mingjian Fei; Wei-Ching Liang; Daniel D. Bravo; Joy Wang; Lanlan Yu; Nick Corr; Gu Zhang; Erin McNamara; Shabkhaiz Masih; Elin Chee; Gawon Shin; Rachana Ohri; Douglas Leipold; Cong Wu; Edward Dere; Jianyong Wang; Haochu Huang; Yan Wu; Minhong Yan

View on Scopus

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, ISSN: 19420870 19420862

Vivekananda Kedage; Diego Ellerman; Mingjian Fei; Wei-Ching Liang; Gu Zhang; Eric Cheng; Juan Zhang; Yongmei Chen; Haochu Huang; Wyne P. Lee; Yan Wu; Minhong Yan

View on Scopus

PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution

Bioconjugate Chemistry, ISSN: 10431802

View on Scopus

PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution

Bioconjugate Chemistry, ISSN: 15204812 10431802

View on Scopus

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Dennis Xiaozhou Hu; Snahel Patel; Huifen Chen; Shumei Wang; Steven T. Staben; Yoana Dimitrova; Heidi J. A. Wallweber; Joanna Y. Lee; Grace Chan; Chris J. Sneeringer; Madeleine S. Prangley; John Moffat; Kai C. Wu; Leah Schutt; Laurent Salphati; Jodie Pang; Erin McNamara; Haochu Huang; Yong Chen; Yunli Wang; Wensheng Zhao; Junghyun Lim; Aditya Murthy; Michael Siu

View on Scopus

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Immunity, ISSN: 10974180 10747613

Yi Zhou; Mingjian Fei; Gu Zhang; Wei-Ching Liang; Wei Yu Lin; Yan Wu; Robert Piskol; John B.B. Ridgway; Erin McNamara; Haochu Huang; Juan Zhang; Jaehak Oh; Jaina M. Patel; Diana Jakubiak; Jeffrey Lau; Beth Blackwood; Daniel D. Bravo; Yongchang Shi; Jianyong Wang; Hong-Ming Hu; Wyne P. Lee; Rajiv Jesudason; Dewakar Sangaraju; Zora Modrusan; Keith R. Anderson; Søren Warming; Merone Roose-Girma; Minhong Yan

View on Scopus

Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity

Cell Reports, ISSN: 22111247

Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum

View on Scopus

Joslin Diabetes Center, Harvard Medical School, Post-doctoral Fellow – 2007
Johns Hopkins University, Ph.D. in Developmental Biology – 2000
University of Science and Technology of China, B.S. in Biology – 1993

Damon Runyon Fellow – 2000-2003

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Haochu Huang

Senior Principal Scientist, Translational Oncology

Featured Publication

Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.