Jae Chang - Senior Scientist, Drug Metabolism and Pharmacokinetics

Jae Chang

Senior Scientist, Drug Metabolism and Pharmacokinetics

11
Years at Genentech
14
Publications

My training is in drug transporters and pharmacokinetics, but I wanted to increase the breadth of my knowledge to get a more complete understanding of how drugs are absorbed, distributed, metabolized and excreted in the body. Therefore, to complement my background, I started my career at Genentech in 2009 in the department of Drug Metabolism and Pharmacokinetics in the in vitro metabolism group. Here, I not only worked with existing in vitro assays, but developed novel assays and approaches to support programs.

After gaining valuable experience to achieve a more comprehensive insight into how the body processes drugs, my role transitioned to become a member of various multi-disciplinary teams focused on driving programs in different stages of R&D. I have been fortunate to work with numerous teams to identify clinical candidates in the preclinical stage and to follow their progression in the clinic.

Featured Publication

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.

Drug Metab Dispos. 2014 Jun;42(6):1067-73.

Chang JH, Ly J, Plise E, Zhang X, Messick K, Wright M, Cheong J.