Genentech: Jae Chang | Senior Scientist, Drug Metabolism & Pharmacokinetics

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Scientists / Our Scientists

Years at Genentech

Publications

My training is in drug transporters and pharmacokinetics, but I wanted to increase the breadth of my knowledge to get a more complete understanding of how drugs are absorbed, distributed, metabolized and excreted in the body. Therefore, to complement my background, I started my career at Genentech in 2009 in the department of Drug Metabolism and Pharmacokinetics in the in vitro metabolism group. Here, I not only worked with existing in vitro assays, but developed novel assays and approaches to support programs.

After gaining valuable experience to achieve a more comprehensive insight into how the body processes drugs, my role transitioned to become a member of various multi-disciplinary teams focused on driving programs in different stages of R&D. I have been fortunate to work with numerous teams to identify clinical candidates in the preclinical stage and to follow their progression in the clinic.

Featured Publication

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.

Drug Metab Dispos. 2014 Jun;42(6):1067-73.

Chang JH, Ly J, Plise E, Zhang X, Messick K, Wright M, Cheong J.

View Abstract

My job focuses on how to best contextualize in vitro data with in vivo exposures to discern which parameter(s) influence the absorption, distribution, metabolism and excretion for a particular drug, with the ultimate goal of augmenting knowledge around human pharmacokinetics and potential for clinical drug interactions. The enhanced understanding of the pharmacokinetic characteristics of a drug can be integrated with endeavors from other functional areas such as biology and safety to enable better informed decision-making, which allows teams to effectively navigate through R&D.

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Gina Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae Chang; Po-Chang Chiang; Coura Diène; Jake Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joe Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoff Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dion Slaga; Minghua Sun; Vickie Tsui; Heidi Ackerly Wallweber; Shang-Fan Yu; Allen Ebens

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Jae Chang

Senior Scientist, Drug Metabolism & Pharmacokinetics

Featured Publication

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.