Jae Chang
Senior Scientist, Drug Metabolism & Pharmacokinetics
14
Years at Genentech
30
Publications
My training is in drug transporters and pharmacokinetics, but I wanted to increase the breadth of my knowledge to get a more complete understanding of how drugs are absorbed, distributed, metabolized and excreted in the body. Therefore, to complement my background, I started my career at Genentech in 2009 in the department of Drug Metabolism and Pharmacokinetics in the in vitro metabolism group. Here, I not only worked with existing in vitro assays, but developed novel assays and approaches to support programs.
After gaining valuable experience to achieve a more comprehensive insight into how the body processes drugs, my role transitioned to become a member of various multi-disciplinary teams focused on driving programs in different stages of R&D. I have been fortunate to work with numerous teams to identify clinical candidates in the preclinical stage and to follow their progression in the clinic.
Featured Publication
Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Drug Metab Dispos. 2014 Jun;42(6):1067-73.
Chang JH, Ly J, Plise E, Zhang X, Messick K, Wright M, Cheong J.
My Focus
My job focuses on how to best contextualize in vitro data with in vivo exposures to discern which parameter(s) influence the absorption, distribution, metabolism and excretion for a particular drug, with the ultimate goal of augmenting knowledge around human pharmacokinetics and potential for clinical drug interactions. The enhanced understanding of the pharmacokinetic characteristics of a drug can be integrated with endeavors from other functional areas such as biology and safety to enable better informed decision-making, which allows teams to effectively navigate through R&D.
Publications
Discovery of Acyl-sulfonamide Nav 1.7 Inhibitors GDC-0276 and GDC-0310
Journal of Medicinal Chemistry, ISSN: 00222623
Brian Safina; Steven J. McKerrall; Shaoyi Sun; Chien-An Chen; Sultan Chowdhury; Qi Jia; Jun Li; Alla Zenova; Jean-Christophe Andrez; Girish Bankar; Philippe Bergeron; Jae Chang; Elaine Chang; Jun Chen; Richard Dean; Shannon M. Decker; Antonio DiPasquale; Thilo Focken; Ivan Hemeon; Kuldip Khakh; Amy Kim; Rainbow Kwan; Andrea Lindgren; Sophia Lin; Jonathan M. Maher; Janette Mezeyova; Misner; Karen Nelkenbrecher; Jodie Pang; Rebecca M. Reese; Shannon Shields; Luis E. Sojo; Tao Sheng; Henry Verschoof; Matthew Waldbrook; Michael S. Wilson; Zhiwei Xie; Clint Young; Tanja Zabka; David Hackos; Dan Ortwine; Andrew D. White; Johnson; C. Lee Robinette; Christoph Dehnhardt; Charles J. Cohen; Dan Sutherlin
ACS Medicinal Chemistry Letters, ISSN: 19485875
Jun Liang; Robert Blake; Jae Chang; Lori Friedman; Simon Goodacre; Steven J. Hartman; Ellen Ingalla; James Kiefer; Tracy Kleinheinz; Sharada Labadie; Jun Li; Kwong Wah Lai; Jiangpeng Liao; Vidhi Mody; Neville J. McLean; Ciara Metcalfe; Michelle Nannini; Daniel Otwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Maia Vinogradova; John Wai; Tao Wang; Kuen Yeap; Amy Young; Jason Zbieg; Birong Zhang; Xiaoping Zheng; Yu Zhong; Gina Wang
Drug Metabolism and Disposition, ISSN: 1521009X
Jae Chang; Yi-Chen Chen; Jonathan Cheong; Robert S. Jones; Jodie Pang
Molecular Pharmaceutics, ISSN: 15438392 15438384
Jae Chang; Dewakar Sangaraju; Ning Liu; Allan Jaochico; Emile Plise
Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Birong Zhang; James Kiefer; Robert Blake; Jae H. Chang; Steven J. Hartman; Ellen Ingalla; Tracy Kleinheinz; Vidhi Mody; Michelle Nannini; Dan Ortwine; Yingqing Ran; Amy Sambrone; Deepak Sampath; Maia Vinogradova; Yu Zhong Yao; Jerome C. Nwachukwu; Kendall W. Nettles; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Hai Chen; Xiaojing Wang; Jun Liang
Clinical Drug Investigation, ISSN: 11791918 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Sharada Labadie; Jun Li; Robert Blake; Jae H. Chang; Simon Goodacre; Steven J. Hartman; Weiling Liang; James Kiefer; Tracy Kleinheinz; Tommy Lai; Jiangpeng Liao; Dan Ortwine; Vidhi Mody; Nicholas C. Ray; Fabien Roussel; Maia Vinogradova; Siew Kuen Yeap; Birong Zhang; Xiaoping Zheng; Jason Zbieg; Jun Liang; Gina Wang
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Gina Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae Chang; Po-Chang Chiang; Coura Diène; Jake Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joe Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoff Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dion Slaga; Minghua Sun; Vickie Tsui; Heidi Ackerly Wallweber; Shang-Fan Yu; Allen Ebens
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV 1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers
Clinical Drug Investigation, ISSN: 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Teresa Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio DiPasquale; Jae Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Dan Ortwine; Jodie Pang; Jian Payandeh; Will Proctor; Shannon Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian Safina; Dan Sutherlin
Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors
Journal of Neuroscience,
Shannon Shields; Lunbin Deng; Rebecca M. Reese; Michelle Dourado; Janet Tao; Oded Foreman; Jae H. Chang; David Hackos
Cell Reports, ISSN: 22111247
Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian Safina; Dan Sutherlin; James P. Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Thilo Focken; Sultan Chowdhury; Alla Zenova; Michael Grimwood; Christine Chabot; Tao Sheng; Ivan Hemeon; Shannon M. Decker; Michael Wilson; Paul Bichler; Qi Jia; Shaoyi Sun; Clint Young; Sophia Lin; Samuel J. Goodchild; Noah Shuart; Elaine Chang; Zhiwei Xie; Bowen Li; Kuldip Khakh; Girish Bankar; Matthew Waldbrook; Rainbow Kwan; Karen Nelkenbrecher; Parisa Karimi Tari; Navjot Chahal; Luis E. Sojo; C. Lee Robinette; Andrew D. White; Chien-An Chen; Yi Zhang; Jodie Pang; Jae Chang; David Hackos; Johnson; Charles J. Cohen; Dan Ortwine; Dan Sutherlin; Christoph Dehnhardt; Brian Safina
Xenobiotica, ISSN: 13665928 00498254
Jae Chang; Xiaolin Zhang; Kirsten Messick; Yi-Chen Chen; Eugene Chen; Jonathan Cheong; Justin Ly
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Ben Sellers; Antonio DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; James P. Johnson; C. Lee Robinette; Charles J. Cohen; Brian Safina; Dan Sutherlin; Dan Ortwine; Christoph Dehnhardt
CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339
Drug Metabolism and Disposition, ISSN: 00909556
Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah Robinson; Aleksandr Kolesnikov; Susan Wong; Gina Wang; Jae Chang
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Sheerin Latham; Susan Wong; Jae Chang
Journal of Medicinal Chemistry, ISSN: 15204804
Gina Wang; Aleksandr Kolesnikov; Suzanne Brown; Grace Chan; Qi Chao; Steven Do; Jake Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dion Slaga; Vickie Tsui; Matthew Volgraf; Heidi Ackerly Wallweber; Jae Chang
Journal of Pharmaceutical Sciences, ISSN: 15206017
Hsin-Fang Wu; Nadya Hristeva; Jae Chang; Xiaorong Liang; Ruina Li; Lynda A. Frassetto; Leslie Z. Benet
Drug Metabolism and Disposition, ISSN: 1521009X
Jae Chang; John Chen; Liling Liu; Kirsten Messick; Justin Ly
ACS Medicinal Chemistry Letters, ISSN: 19485875
Thilo Focken; Shifeng Liu; Navjot Chahal; Maxim Dauphinais; Michael Grimwood; Sultan Chowdhury; Ivan Hemeon; Paul Bichler; David Bogucki; Matthew Waldbrook; Girish Bankar; Luis E. Sojo; Clint Young; Sophia Lin; Noah Shuart; Rainbow Kwan; Jodie Pang; Jae Chang; Brian Safina; Dan Sutherlin; Johnson; Christoph Dehnhardt; Tarek S. Mansour; Renata M. Oballa; Charles J. Cohen; C. Lee Robinette
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Huiyong Hu; Gina Wang; Grace Chan; Jae Chang; Steven Do; Jake Drummond; Allen Ebens; Wendy Lee; Justin Ly; Joe Lyssikatos; Jeremy Murray; John Moffat; Qi Chao; Vickie Tsui; Heidi Ackerly Wallweber; Aleksandr Kolesnikov
ACS Medicinal Chemistry Letters, ISSN: 19485875
Gina Wang; Minghua Sun; Connie New; Spencer Nam; Wesley P. Blackaby; Alastair J. Hodges; David Nash; Mizio Matteucci; Joe Lyssikatos; Peter Fan; Suzanne Brown; Jae Chang
Drug Metabolism and Disposition, ISSN: 1521009X
Jae Chang; Justin Ly; Emile Plise; Xiaolin Zhang; Kirsten Messick; Matthew Wright; Jonathan Cheong
Molecular Pharmaceutics, ISSN: 15438384
Jae Chang; Emile Plise; Jonathan Cheong; Quynh Ho; Molly Lin
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Miki Susanto Park; Jae Chang
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Jae Chang; James A. Uchizono; Miki Susanto Park
Toxicological Sciences, ISSN: 10960929
Phuong Minh Nguyen; Miki Susanto Park; Marilynn Chow; Jae Chang; Lisa Wrischnik; William K. Chan
Education
- University of California, San Francisco, PhD in Pharmaceutical Sciences – 2004
- Duke University, BS in Chemistry; BA in History – 1997