My training is in drug transporters and pharmacokinetics, but I wanted to increase the breadth of my knowledge to get a more complete understanding of how drugs are absorbed, distributed, metabolized and excreted in the body. Therefore, to complement my background, I started my career at Genentech in 2009 in the department of Drug Metabolism and Pharmacokinetics in the in vitro metabolism group. Here, I not only worked with existing in vitro assays, but developed novel assays and approaches to support programs.
After gaining valuable experience to achieve a more comprehensive insight into how the body processes drugs, my role transitioned to become a member of various multi-disciplinary teams focused on driving programs in different stages of R&D. I have been fortunate to work with numerous teams to identify clinical candidates in the preclinical stage and to follow their progression in the clinic.
Drug Metab Dispos. 2014 Jun;42(6):1067-73.
My job focuses on how to best contextualize in vitro data with in vivo exposures to discern which parameter(s) influence the absorption, distribution, metabolism and excretion for a particular drug, with the ultimate goal of augmenting knowledge around human pharmacokinetics and potential for clinical drug interactions. The enhanced understanding of the pharmacokinetic characteristics of a drug can be integrated with endeavors from other functional areas such as biology and safety to enable better informed decision-making, which allows teams to effectively navigate through R&D.