James Crawford
Distinguished Scientist and Senior Director, Discovery Chemistry
"The opportunity to do innovative research to discover transformational therapies with talented, passionate scientists makes Genentech a special place."
13
Years at Genentech
54
Publications at Genentech
9
Awards & Honors
I am a Director and Project Team Leader in our small molecule drug discovery group. I was born and raised in Glasgow, Scotland, and obtained my MSci and Ph.D. degrees in chemistry from the University of Strathclyde. In 2005, I joined Professor K.C. Nicolaou’s laboratory at The Scripps Research Institute as a Fulbright scholar, before starting my industrial career in 2006 with AstraZeneca in their Respiratory and Inflammation group. At Genentech I'm excited by the opportunity to do leading-edge research with world class biologists and drug hunters every day.
Featured Publication
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton0s Tyrosine Kinase Inhibitor in Early Clinical Development.
J Med Chem. 2018 Mar 22;61(6):2227-2245.
Crawford JJ, Johnson AR, Misner DL, Belmont LD, Castanedo G, Choy R, Coraggio M, Dong L, Eigenbrot C, Erickson R, Ghilardi N, Hau J, Katewa A, Kohli PB, Lee W, Lubach JW, McKenzie BS, Ortwine DF, Schutt L, Tay S, Wei B, Reif K, Liu L, Wong H, Young WB.
My Focus
Here, I have worked across four main disease areas – Immunology, Oncology, Infectious Disease, and Regenerative Medicine – with one of my key roles being the chemistry leader of the BTK project team. In addition to my work on therapeutic projects, I am interested in the development of molecular design and analysis tools, diverse hit-finding methods, and the use of chemical and genetic probes to study undrugged biological pathways.
Genentech Publications
Nature Communications, ISSN: 20411723
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
Nature Communications,
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
ACS Medicinal Chemistry Letters, ISSN: 19485875
Yong Wang; Wendy Lee; Yi-Chen Chen; Yuhui Zhou; Emile G. Plise; Madyson M. Migliozzi; James J. Crawford
ACS Medicinal Chemistry Letters, ISSN: 19485875
Matthew L. Landry; Richard Trager; Broccatelli; James J. Crawford
ACS Medicinal Chemistry Letters, ISSN: 19485875
Yong Wang; Wendy Lee; Yi-Chen Chen; Yuhui Zhou; Emile G. Plise; Madyson M. Migliozzi; James J. Crawford
ACS Medicinal Chemistry Letters,
Yong Wang; Wendy Lee; Yi-Chen Chen; Yuhui Zhou; Emile G. Plise; Madyson M. Migliozzi; James J. Crawford
ACS Medicinal Chemistry Letters, ISSN: 19485875
Matthew L. Landry; Richard Trager; Broccatelli; James J. Crawford
Chemical Science, ISSN: 20416539 20416520
James H. Hunter; Matthew J. Anderson; Isaline F. S. F. Castan; Jessica S. Graham; Catherine L. A. Salvini; Harriet A. Stanway-Gordon; James J. Crawford; Andrew Madin; Garry Pairaudeau; Michael J. Waring
Synthesis (Germany), ISSN: 1437210X 00397881
James J. Crawford; Daohong Liao; Aleksandr Kolesnikov; Wendy Lee; Matthew L. Landry
ACS Medicinal Chemistry Letters, ISSN: 19485875
James J. Crawford; Wendy Lee; Adam R. Johnson; Kelly Delatorre; Jacob Z. Chen; Eigenbrot; Julia Heidmann; Satoko Kakiuchi-Kiyota; Arna Katewa; James R. Kiefer; Lichuan Liu; Joseph W. Lubach; Misner; Hans E. Purkey; Karin Reif; Jennifer Vogt; Harvey Wong; Christine Yu; Wendy B. Young
Chemical Research in Toxicology, ISSN: 15205010 0893228X
Chenghong Zhang; James J. Crawford; Matthew L. Landry; Huifen Chen; Jane R. Kenny; S. Cyrus Khojasteh; Wendy Lee; Shuguang Ma; Wendy B. Young
Cell Reports, ISSN: 22111247
Jeffrey K. Holden; James J. Crawford; Cameron Noland; Stephen Schmidt; Jason R. Zbieg; Jennifer A. Lacap; Richard Zang; Gregory M. Miller; Yue Zhang; Paul Beroza; Rohit Reja; Wendy Lee; Jeffrey Tom; Rina Fong; Micah Steffek; Saundra Clausen; Thijs Hagenbeek; Taishan Hu; Zheng Zhou; Hong C. Shen; Christian N. Cunningham
Science Signaling, ISSN: 19379145
Cesar A. Corzo; Eugene Varfolomeev; A F. Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeffrey Eastham-Anderson; Arna Katewa; Jodie Pang; Melanie Domeyer; Christopher Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans D. Brightbill; Søren Warming; Merone Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James J. Crawford; Wendy B. Young; Rajita Pappu; Brent Mckenzie; Vida Asghari; Domagoj Vucic; Jason A. Hackney; Cary D. Austin; Wyne P. Lee; Annemarie N. Lekkerkerker; Nico Ghilardi; Marian C. Bryan; James R. Kiefer; Michael J. Townsend; Ali A. Zarrin
Science Signaling, ISSN: 19379145 19450877
Cesar A. Corzo; Eugene Varfolomeev; A F. Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeffrey Eastham-Anderson; Arna Katewa; Jodie Pang; Melanie Domeyer; Christopher Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans D. Brightbill; Søren Warming; Merone Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James J. Crawford; Wendy B. Young; Rajita Pappu; Brent Mckenzie; Vida Asghari; Domagoj Vucic; Jason A. Hackney; Cary D. Austin; Wyne P. Lee; Annemarie N. Lekkerkerker; Nico Ghilardi; Marian C. Bryan; James R. Kiefer; Michael J. Townsend; Ali A. Zarrin
ACS Medicinal Chemistry Letters, ISSN: 19485875
Matthew L. Landry; James J. Crawford
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sarah M. Bronner; Karl A. Merrick; Jeremy Murray; Laurent Salphati; John Moffat; Jodie Pang; Chris J. Sneeringer; Nicholas A. Dompe; Patrick Cyr; Hans E. Purkey; Gladys de Leon Boenig; Jun Li; Aleksandr Kolesnikov; Larouche-Gauthier; Kwong Wah Lai; Xiaoli Shen; Samuel Aubert-Nicol; Yi-Chen Chen; Jonathan Cheong; James J. Crawford; Marc Hafner; Pouyan Haghshenas; Araz Jakalian; Jean-Philippe Leclerc; Ngiap-Kie Lim; Thomas O'Brien; Emile G. Plise; Shalan; Claudio Sturino; John Wai; Yang Xiao; Jianping Yin; Zhao; Stephen Gould; Alan G. Olivero; Timothy P. Heffron
Frontiers in Cell and Developmental Biology, ISSN: 2296634X
Satoko Kakiuchi-Kiyota; Melissa Schutten; Yu Zhong; James J. Crawford; Anwesha Dey
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Karthik Nagapudi; Jia Liu; James J. Crawford; Jason R. Zbieg; Emile G. Plise; Yuzhong Deng
Trends in Cancer, ISSN: 24058033
Philamer C. Calses; James J. Crawford; Jennie R. Lill; Anwesha Dey
ACS Symposium Series, ISSN: 19475918 00976156
James J. Crawford; Haiming Zhang
Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776
James J. Crawford; Sarah M. Bronner; Jason R. Zbieg
Nature, ISSN: 14764687 00280836
Peter A. Smith; Michael F. T. Koehler; Hany S. Girgis; Donghong Yan; Yongsheng Chen; Yuan Chen; James J. Crawford; Matthew Durk; Robert I. Higuchi; Jing Kang; Jeremy Murray; Prasuna Paraselli; Summer Park; Wilson Phung; John Quinn; Tucker C. Roberts; Lionel Rouge; Jacob B. Schwarz; Elizabeth Skippington; John Wai; Min Xu; Zhiyong Yu; Hua Zhang; Man-Wah Tan; Christopher E. Heise
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette M. Castanedo; Jason D. Burch; Leonid M. Berezhkovskiy; Hans D. Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter W. Fan; Jianwen A. Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah G. Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne P. Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent Mckenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren C. Wu; Yamin Zhang; Zoe Zhong; Steven T. Staben
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Christian Kramer; Attilla Ting; Hao Zheng; Jérôme Hert; Torsten Schindler; Martin Stahl; Graeme Robb; James J. Crawford; Jeff Blaney; Shane Montague; Andrew G. Leach; Alexander G. Dossetter; Ed J. Griffen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
James J. Crawford; Adam R. Johnson; Misner; Lisa D. Belmont; Georgette M. Castanedo; Regina Choy; Melis Coraggio; Liming Dong; Eigenbrot; Rebecca Erickson; Nico Ghilardi; Jonathan Hau; Arna Katewa; Pawan Bir Kohli; Wendy Lee; Joseph W. Lubach; Brent Mckenzie; Daniel F. Ortwine; Leah Schutt; Suzanne Tay; Binqing Wei; Karin Reif; Lichuan Liu; Harvey Wong; Wendy B. Young
Nature Communications, ISSN: 20411723
Hans D. Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette M. Castanedo; Benjamin T. Jackson; Youngsu C. Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leonid M. Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael J. Townsend; Jason Devoss; Adam R. Johnson; Robert Godemann; Wyne P. Lee; Cary D. Austin; Brent Mckenzie; Jason A. Hackney; James J. Crawford; Steven T. Staben; Moulay Hicham Alaoui-Ismaili; Lawren C. Wu; Nico Ghilardi
ACS Medicinal Chemistry Letters, ISSN: 19485875
Xiaojing Wang; Jim Barbosa; Peter Blomgren; Meire C. Bremer; Jacob Z. Chen; James J. Crawford; Wei Deng; Liming Dong; Eigenbrot; Steven L. Gallion; Jonathan Hau; Huiyong Hu; Adam R. Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie Dipaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy B. Young
JCI insight, ISSN: 23793708
Arna Katewa; Yugang Wang; Jason A. Hackney; Tao Huang; Eric Suto; Nandhini Ramamoorthi; Cary D. Austin; Meire C. Bremer; Jacob Z. Chen; James J. Crawford; Kevin S. Currie; Peter Blomgren; Jason Devoss; Julie Dipaolo; Jonathan Hau; Adam R. Johnson; Justin Lesch; Laura DeForge; Zhonghua Lin; Marya Liimatta; Joseph W. Lubach; Sami McVay; Zora Modrusan; Allen Nguyen; Chungkee Poon; Jianyong Wang; Lichuan Liu; Wyne P. Lee; Harvey Wong; Wendy B. Young; Michael J. Townsend; Karin Reif
Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776
Sarah M. Bronner; Jason R. Zbieg; James J. Crawford
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Rebecca Erickson; Leah Schutt; Jacqueline M. Tarrant; Michelle Mcdowell; Lichuan Liu; Adam R. Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Ross; Richard A. D. Carano; Karin Staflin; Fiona Zhong; James J. Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy B. Young; Donna M. Dambach; Misner
ACS Chemical Biology, ISSN: 15548937 15548929
Adam R. Johnson; Pawan Bir Kohli; Arna Katewa; Emily Gogol; Lisa D. Belmont; Regina Choy; Elicia M. Penuel; Luciana Burton; Eigenbrot; Christine Yu; Daniel F. Ortwine; Krista K. Bowman; Yvonne Franke; Christine Tam; Alberto Estevez; Kyle Mortara; Jiansheng Wu; Hong Li; May Lin; Philippe Bergeron; James J. Crawford; Wendy B. Young
Journal of Organic Chemistry, ISSN: 15206904 00223263
Georgette M. Castanedo; Yanzhou Liu; James J. Crawford; Marie-Gabrielle Braun
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Patrick Cyr; Sarah M. Bronner; James J. Crawford
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Joachim Rudolph; Lesley J. Murray; Chudi O. Ndubaku; Thomas O'Brien; Elizabeth M. Blackwood; Weiru Wang; Ignacio Aliagas; Lewis Gazzard; James J. Crawford; Joy Drobnick; Wendy Lee; Xianrui Zhao; Klaus P. Hoeflich; David A. Favor; Ping Dong; Haiming Zhang; Christopher E. Heise; Angela Oh; Christy C. Ong; Hank La; Paroma Chakravarty; Connie Chan; Diana Jakubiak; Jennifer A. Epler; Sreemathy Ramaswamy; Roxanne Vega; Cain; Dolores Diaz; Yu Zhong
Drug Metabolism Letters, ISSN: 18723128
Peter W. Fan; Jacob Z. Chen; Allan Jaochico; Hank La; Ning Liu; Teresa Mulder; Robert T. Cass; Matthew Durk; Kirsten Messick; Nicole R. Valle; Shannon Liu; Wendy Lee; James J. Crawford; Joachim Rudolph; Lesley J. Murray; S. Cyrus Khojasteh; Matthew Wright
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Eigenbrot; Steven L. Gallion; Adam R. Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy Lee; James J. Crawford; Ignacio Aliagas; Lesley J. Murray; Suzanne Tay; Weiru Wang; Christopher E. Heise; Klaus P. Hoeflich; Hank La; Simon Mathieu; Robert Mintzer; Sreemathy Ramaswamy; Lionel Rouge; Joachim Rudolph
ACS Medicinal Chemistry Letters, ISSN: 19485875
Chudi O. Ndubaku; James J. Crawford; Joy Drobnick; Ignacio Aliagas; David Campbell; Ping Dong; Laura M. Dornan; Sergio G. Duron; Jennifer A. Epler; Lewis Gazzard; Christopher E. Heise; Klaus P. Hoeflich; Diana Jakubiak; Hank La; Wendy Lee; Baiwei Lin; Joseph P. Lyssikatos; Jasna Maksimoska; Ronen Marmorstein; Lesley J. Murray; Thomas O'Brien; Angela Oh; Sreemathy Ramaswamy; Weiru Wang; Xianrui Zhao; Yu Zhong; Elizabeth M. Blackwood; Joachim Rudolph
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
James J. Crawford; Wendy Lee; Ignacio Aliagas; Simon Mathieu; Klaus P. Hoeflich; Wei Zhou; Weiru Wang; Lionel Rouge; Lesley J. Murray; Hank La; Ning Liu; Peter W. Fan; Jonathan Cheong; Christopher E. Heise; Sreemathy Ramaswamy; Robert Mintzer; Yanzhou Liu; Qi Chao; Joachim Rudolph
ACS Medicinal Chemistry Letters, ISSN: 19485875
Joachim Rudolph; Ignacio Aliagas; James J. Crawford; Simon Mathieu; Wendy Lee; Qi Chao; Ping Dong; Lionel Rouge; Weiru Wang; Christopher E. Heise; Lesley J. Murray; Hank La; Yanzhou Liu; Gerard Manning; François Diederich; Klaus P. Hoeflich
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Weiru Wang
Bioorganic and Medicinal Chemistry, ISSN: 14643391
Adele E. Pasqua; Frank D. Ferrari; James J. Crawford; William G. Whittingham; Rodolfo Marquez
Tetrahedron, ISSN: 00404020 14645416
Brian Wong; Xin Linghu; James J. Crawford; Joy Drobnick; Wendy Lee; Haiming Zhang
Chemical Communications, ISSN: 1364548X 13597345
Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon
Enzymes, ISSN: 18746047
Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Jonathan Chernoff
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James J. Crawford; Peter W. Kenny; Jonathan Bowyer; Calum R. Cook; Jonathan E. Finlayson; Christine Heyes; Adrian J. Highton; Julian A. Hudson; Anja Jestel; Stephan Krapp; Scott Martin; Philip A. MacFaul; Benjamin P. McDermott; Thomas M. McGuire; Andrew D. Morley; Jeffrey J. Morris; Ken M. Page; Lyn Rosenbrier Ribeiro; Helen Sawney; Stefan Steinbacher; Caroline Smith; Alexander G. Dossetter
Journal of Organic Chemistry, ISSN: 00223263 15206904
Adele E. Pasqua; Frank D. Ferrari; Chris Hamman; Yanzhou Liu; James J. Crawford; Rodolfo Marquez
Tetrahedron Letters, ISSN: 00404039 18733581
Adele E. Pasqua; Frank D. Ferrari; James J. Crawford; Rodolfo Marquez
Journal of Organic Chemistry, ISSN: 00223263 15206904
Adele E. Pasqua; James J. Crawford; De-Liang Long; Rodolfo Marquez
Expert Opinion on Therapeutic Patents, ISSN: 13543776 17447674
James J. Crawford; Klaus P. Hoeflich; Joachim Rudolph
Tetrahedron, ISSN: 00404020 14645416
Adele E. Pasqua; Lynne H. Thomas; James J. Crawford; Rodolfo Marquez
Chemical Communications, ISSN: 1364548X 13597345
James J. Crawford; Ben J. Fleming; Alan R. Kennedy; Charles T. O’Hara; Samantha A. Orr
Chemical Communications, ISSN: 1364548X 13597345
James J. Crawford; Ben J. Fleming; Kennedy; Charles T. O’Hara; Samantha A. Orr
Education
- The University of Strathclyde, Glasgow, Ph.D. in Chemistry – 2005
- The University of Strathclyde, Glasgow, MSci with First Class Honours in Chemistry – 2001
Awards & Honors
- Genentech Innovation Grant – 2020
- Genentech Inventor Award – 2018
- Royal Society of Chemistry Capps Green Zomaya Award for Medicinal Chemistry – 2018
- Fellow of the Royal Society of Chemistry – 2017
- Genentech Innovation Award – 2015
- Fulbright-AstraZeneca Scholarship – 2005
- Roche Symposium for Leading Chemists of the Next Decade awardee – 2004
- Scottish International Education Trust award – 2004
- Zeneca Prize for outstanding performance in Synthetic Chemistry – 2001