James Ernst - Senior Scientist, Protein Chemistry

James Ernst

Senior Scientist, Protein Chemistry

Postdoc Mentor
"I feel privileged to work in a stimulating and collaborative environment as part of an organization that strives to provide meaningful treatment of human disease."
Years at Genentech
Awards & Honors

I joined the Protein Chemistry Department at Genentech in 2002 after completing a post-doctoral fellowship at Stanford University. At that time, and today, Genentech places tremendous value on collaborations between the therapeutic areas and technology groups like Protein Chemistry to facilitate the development of novel therapeutics. Currently, my group is focused on the development of novel molecules for indications in cancer immunotherapy and treatments of neurodegenerative diseases.

Postdoctoral Mentor

The postdoctoral program at Genentech is essential maintaining cutting edge basic and translational research. Post-doctoral projects at the company often lay the ground work for new therapeutic target or alternatively, can help us understand the mechanism of action of existing therapeutics. Post-doctoral projects in my lab focus cell and tissue pentation properties of large or small molecules and the interaction of antibodies with Fc receptors.

Featured Publication

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.

J Biol Chem. 2017 Mar 3;292(9):3900-3908.

Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, Spiess C, Ernst JA.

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

EBioMedicine. 2015 May 30;2(7):730-43.

Kolumam G, Chen MZ, Tong R, Zavala-Solorio J, Kates L, van Bruggen N, Ross J, Wyatt SK, Gandham VD, Carano RA, Dunshee DR, Wu AL, Haley B, Anderson K, Warming S, Rairdan XY, Lewin-Koh N, Zhang Y, Gutierrez J, Baruch A, Gelzleichter TR, Stevens D, Rajan S, Bainbridge TW, Vernes JM, Meng YG, Ziai J, Soriano RH, Brauer MJ, Chen Y, Stawicki S, Kim HS, Comps-Agrar L, Luis E, Spiess C, Wu Y, Ernst JA, McGuinness OP, Peterson AS, Sonoda J.