James Ernst - Senior Scientist, ADCs and Therapeutic Proteins/Protein Chemistry

James Ernst

Senior Scientist, ADCs and Therapeutic Proteins/Protein Chemistry

"I feel privileged to work in a stimulating and collaborative environment as part of an organization that strives to provide meaningful treatment of human disease."
Years at Genentech
Awards & Honors

I joined Genentech in September of 2002 as an Associate Scientist in the Protein Chemistry Department. At that time, and today, Genentech places tremendous value on the collaboration between the therapeutic and Protein Science groups to facilitate the development of novel therapeutics.

Part of the reward and challenge of working at Genentech is the creativity and flexibility that is expected of our researchers. Our project teams are constantly working to evaluate topics from a broad perspective. Our researchers are, in turn, expected to effectively address a variety of topics. Early in my career, my lab focused on the identification of novel inhibitors of the Hedgehog and Wnt pathways and small molecule inhibitors to prevent ubiquitination of the proto-oncogene p53. More recently, my group has added a focus on neurodegeneration, metabolic disease and antibody-drug conjugates.

Featured Publication

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

EBioMedicine. 2015 May 30;2(7):730-43.

Kolumam G, Chen MZ, Tong R, Zavala-Solorio J, Kates L, van Bruggen N, Ross J, Wyatt SK, Gandham VD, Carano RA, Dunshee DR, Wu AL, Haley B, Anderson K, Warming S, Rairdan XY, Lewin-Koh N, Zhang Y, Gutierrez J, Baruch A, Gelzleichter TR, Stevens D, Rajan S, Bainbridge TW, Vernes JM, Meng YG, Ziai J, Soriano RH, Brauer MJ, Chen Y, Stawicki S, Kim HS, Comps-Agrar L, Luis E, Spiess C, Wu Y, Ernst JA, McGuinness OP, Peterson AS, Sonoda J.