Joseph Ware - Principal Scientist, Clinical Pharmacology, Department of Development Sciences

Joseph Ware

Principal Scientist, Clinical Pharmacology, Department of Development Sciences

"Precision medicine and personalized health care have always been at the heart of our DNA at Genentech. My goal is to integrate precision medicine efforts into a comprehensive clinical pharmacology strategy to improve patient care."
10
Years at Genentech
5
Awards & Honors

Since joining Genentech in the Fall of 2007, my primary responsibilities include development of an integrated clinical pharmacology strategy to support oncology drug development and global registration. I was an original member of the International Transport Consortia (ITC), which includes many scientists from academia, FDA and industry. Collectively, the ITC published Membrane Transporters in Drug Development in Nature Reviews Drug Discovery in 2010 to aid drug development in this rapidly evolving field and I have been investigating the impact of pH-dependent solubility on the absorption and pharmacokinetics of anti-cancer drugs. Most recently, our group is working to establish precision medicine efforts within clinical pharmacology to better understand pharmacokinetic variability and adverse drug reactions of investigational drugs and standard-of care drug therapy. Throughout my industrial career, I have had the opportunity to coach and mentor undergraduate, graduate and post-graduate scientists. I also actively contribute to the American Society of Clinical Pharmacology and Therapeutics (ASCPT) organization.

Featured Publication

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?

Clin Pharmacol Ther. 2012 Aug; 92(2): 203-13.

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA.