"Collaboration is a key ingredient to making scientific discoveries that are game changing. I am fortunate to be able to interact with some of the smartest and most deeply committed scientists every day."
I received my Ph.D in Charlie Boone’s Lab in 2003 (Queen’s University, Canada) and then joined Fred de Sauvage’s Lab at Genentech as a postdoctoral fellow in 2004. In 2009 I was hired as a Scientist and over the past few years have focused on some of the most challenging but important targets in Oncology.
I was inspired to work at Genentech because it is one of the only institutes in the world that conducts ground breaking basic science and translates this knowledge into medicines that make a real difference in patient’s lives.
Doing a postdoc at Genentech was the best decision I made for my scientific career. I received world-class training but also experienced what it is like to work in biotech.
As a Scientist, mentoring a postdoc has been a rich and rewarding experience. I have found that Genentech postdocs are highly motivated risk-takers that can elevate your science to another level.
My lab has focused on identifying and targeting vulnerabilities, such as cell cycle checkpoints and altered metabolism, as a consequence of oncogenic signaling in tumors.
More recently, we have become interested in understanding how mutant oncogenic allele and gene dosage heterogeneity in tumors impacts cell fitness, vulnerability to cellular stress, and ultimately therapeutic drug response. We are using CRISPR/Cas9 and barcoding technologies to model this heterogeneity in tumor cells.