Matthew Volgraf - Principal Scientist (Chemistry), Discovery Chemistry

Matthew Volgraf

Principal Scientist (Chemistry), Discovery Chemistry

"I’m motivated by the opportunity to work with talented colleagues on the toughest scientific problems."
Years at Genentech
Publications at Genentech
Awards & Honors

I joined Genentech in 2010 after completing my PhD at UC Berkeley with Prof. Dirk Trauner, followed by a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center with Prof. David Gin. My academic background in chemical biology and natural product total synthesis prepared me for the collaborative, multi-disciplinary team environment which is central to Genentech’s culture.

Featured Publication

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

J Med Chem. 2016 Mar 24;59(6):2760-79.

Volgraf M, Sellers BD, Jiang Y, Wu G, Ly CQ, Villemure E, Pastor RM, Yuen PW1, Lu A, Luo X, Liu M, Zhang S, Sun L, Fu Y, Lupardus PJ, Wallweber HJ, Liederer BM, Deshmukh G, Plise E, Tay S, Reynen P, Herrington J, Gustafson A, Liu Y, Dirksen A, Dietz MG, Liu Y, Wang TM, Hanson JE, Hackos D, Scearce-Levie K, Schwarz JB.