Matthew Volgraf
Principal Scientist (Chemistry), Discovery Chemistry
"I’m motivated by the opportunity to work with talented colleagues on the toughest scientific problems."
12
Years at Genentech
17
Publications at Genentech
4
Awards & Honors
I joined Genentech in 2010 after completing my PhD at UC Berkeley with Prof. Dirk Trauner, followed by a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center with Prof. David Gin. My academic background in chemical biology and natural product total synthesis prepared me for the collaborative, multi-disciplinary team environment which is central to Genentech’s culture.
Featured Publication
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J Med Chem. 2016 Mar 24;59(6):2760-79.
Volgraf M, Sellers BD, Jiang Y, Wu G, Ly CQ, Villemure E, Pastor RM, Yuen PW1, Lu A, Luo X, Liu M, Zhang S, Sun L, Fu Y, Lupardus PJ, Wallweber HJ, Liederer BM, Deshmukh G, Plise E, Tay S, Reynen P, Herrington J, Gustafson A, Liu Y, Dirksen A, Dietz MG, Liu Y, Wang TM, Hanson JE, Hackos D, Scearce-Levie K, Schwarz JB.
My Focus
My current role in the Discovery Chemistry department has been focused on developing small molecule drugs targeting ion channels within the neuroscience and immunology therapeutic areas. I am interested in studying the principles of drug design targeting membrane-bound enzymes and receptors, together with the physicochemical rules governing blood-brain barrier penetration.
Genentech Publications
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Jian Payandeh; Matthew Volgraf
ACS Medicinal Chemistry Letters, ISSN: 19485875
Elisia Villemure; Jack A. Terrett; Larouche-Gauthier; Martin Déry; Huifen Chen; Rebecca M. Reese; Shannon D. Shields; Jun Chen; Steven Magnuson; Matthew Volgraf
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Jack A. Terrett; Huifen Chen; Daniel G. Shore; Elisia Villemure; Larouche-Gauthier; Martin Déry; Francis Beaumier; Léa Constantineau-Forget; Chantal Grand-Maître; Luce Lépissier; Stéphane Ciblat; Claudio Sturino; Yong Chen; Baihua Hu; Aijun Lu; Yunli Wang; Andrew P. Cridland; Stuart I. Ward; David Hackos; Rebecca M. Reese; Shannon D. Shields; Jun Chen; Alessia Balestrini; Lorena Riol-Blanco; Wyne P. Lee; John Liu; Eric Suto; Xiumin Wu; Juan Zhang; Justin Ly; Hank La; Kevin Johnson; Matthew Baumgardner; Kang-Jye Chou; Alexis Rohou; Lionel Rouge; Brian S. Safina; Steven Magnuson; Matthew Volgraf
Neuron, ISSN: 10974199 08966273
Chang Liu; Rebecca M. Reese; Simon Vu; Lionel Rouge; Shannon D. Shields; Satoko Kakiuchi-Kiyota; Huifen Chen; Kevin Johnson; Yu Patrick Shi; Tania Chernov-Rogan; Demi Maria Zabala Greiner; Pawan Bir Kohli; David Hackos; Bobby Brillantes; Christine Tam; Tianbo Li; Jianyong Wang; Brian S. Safina; Steven Magnuson; Matthew Volgraf; Jian Payandeh; Jie Zheng; Alexis Rohou; Jun Chen
Journal of Experimental Medicine, ISSN: 15409538 00221007
Alessia Balestrini; Victory Joseph; Michelle Dourado; Rebecca M. Reese; Shannon D. Shields; Lionel Rouge; Daniel D. Bravo; Tania Chernov-Rogan; Cary D. Austin; Huifen Chen; Lan Wang; Elisia Villemure; Daniel G. Shore; Vishal A. Verma; Baihua Hu; Yong Chen; Laurie Leong; Chris Bjornson; Kathy Hötzel; Alvin Gogineni; Wyne P. Lee; Eric Suto; Xiumin Wu; John Liu; Juan Zhang; Vineela D. Gandham; Jianyong Wang; Jian Payandeh; Claudio Ciferri; Alberto Estevez; Christopher P. Arthur; Jens Kortmann; Ryan L. Wong; Jose Heredia; Jonas Martin Doerr; Min Jung; Jason A. Vander Heiden; Merone Roose-Girma; Lucinda Tam; Kai H. Barck; Richard A. D. Carano; Han Ting Ding; Bobby Brillantes; Christine Tam; Xiaoying Yang; Simon S. Gao; Justin Ly; Liling Liu; Liuxi Chen; Bianca M. Liederer; Joseph Lin; Steven Magnuson; Jun Chen; David Hackos; Justin Elstrott; Alexis Rohou; Brian S. Safina; Matthew Volgraf; Rebecca N. Bauer; Lorena Riol-Blanco
Cell Reports, ISSN: 22111247
Jesse E. Hanson; Keran Ma; Justin Elstrott; Martin Weber; Sandrine Saillet; Abdullah S. Khan; Jeffrey Simms; Benjamin Liu; Thomas A. Kim; Gui-Qiu Yu; Yelin Chen; Tzu-Ming Wang; Zhiyu Jiang; Bianca M. Liederer; Gauri Deshmukh; Hilda Solanoy; Connie Chan; Benjamin D. Sellers; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Robby M. Weimer; Morgan Sheng; T. Michael Gill; Kimberly Scearce-Levie; Jorge J. Palop
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Tania Chernov-Rogan; Eleonora Gianti; Chang Liu; Elisia Villemure; Andrew P. Cridland; Xiaoyu Hu; Elisa Ballini; Wienke Lange; Heike Deisemann; Tianbo Li; Stuart I. Ward; David Hackos; Steven Magnuson; Brian S. Safina; Michael L. Klein; Matthew Volgraf; Vincenzo Carnevale; Jun Chen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Huifen Chen; Matthew Volgraf; Steven Do; Aleksandr Kolesnikov; Daniel G. Shore; Vishal A. Verma; Elisia Villemure; Lan Wang; Yong Chen; Baihua Hu; Aijun Lu; Guosheng Wu; Xiaofeng Xu; Po-Wai Yuen; Yamin Zhang; Shawn D. Erickson; Martin Dahl; Christine Brotherton-Pleiss; Suzanne Tay; Justin Ly; Lesley J. Murray; Jun Chen; Desiree Amm; Wienke Lange; David Hackos; Rebecca M. Reese; Shannon D. Shields; Joseph P. Lyssikatos; Brian S. Safina; Anthony A. Estrada
Neuropharmacology, ISSN: 18737064 00283908
Tzu-Ming Wang; Brandon M. Brown; Lunbin Deng; Benjamin D. Sellers; Patrick J. Lupardus; Heidi J. A. Wallweber; Amy Gustafson; Evera Wong; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Jesse E. Hanson
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Xiaojing Wang; Aleksandr Kolesnikov; Suzanne Tay; Grace Chan; Qi Chao; Steven Do; Jason H. Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dionysos S. Slaga; Vickie Tsui; Matthew Volgraf; Heidi J. A. Wallweber; Jae H. Chang
ACS Medicinal Chemistry Letters, ISSN: 19485875
Elisia Villemure; Matthew Volgraf; Yu Jiang; Guosheng Wu; Cuong Q. Ly; Po-Wai Yuen; Aijun Lu; Xifeng Luo; Mingcui Liu; Shun Zhang; Patrick J. Lupardus; Heidi J. A. Wallweber; Bianca M. Liederer; Gauri Deshmukh; Emile G. Plise; Suzanne Tay; Tzu-Ming Wang; Jesse E. Hanson; David Hackos; Kimberly Scearce-Levie; Jacob B. Schwarz; Benjamin D. Sellers
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Matthew Volgraf; Benjamin D. Sellers; Yu Jiang; Guosheng Wu; Cuong Q. Ly; Elisia Villemure; Richard Pastor; Po-Wai Yuen; Aijun Lu; Xifeng Luo; Mingcui Liu; Shun Zhang; Liang Sun; Yuhong Fu; Patrick J. Lupardus; Heidi J. A. Wallweber; Bianca M. Liederer; Gauri Deshmukh; Emile G. Plise; Suzanne Tay; Paul Reynen; James Herrington; Amy Gustafson; Yichin Liu; Akim Dirksen; Matthias G. A. Dietz; Yanzhou Liu; Tzu-Ming Wang; Jesse E. Hanson; David Hackos; Kimberly Scearce-Levie; Jacob B. Schwarz
Neuron, ISSN: 10974199 08966273
David Hackos; Patrick J. Lupardus; Teddy Grand; Yelin Chen; Tzu-Ming Wang; Paul Reynen; Amy Gustafson; Heidi J. A. Wallweber; Matthew Volgraf; Benjamin D. Sellers; Jacob B. Schwarz; Pierre Paoletti; Morgan Sheng; Qiang Zhou; Jesse E. Hanson
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Matthew Volgraf; Lina Chan; Malcolm P. Huestis; Hans E. Purkey; Michael Burkard; Mary K. Geck Do; Julie Harris; Kevin W. Hunt; Xingrong Liu; Joseph P. Lyssikatos; Sumeet Rana; Allen A. Thomas; Guy Vigers; Michael Siu
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Allen A. Thomas; Kevin W. Hunt; Matthew Volgraf; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Douglas Sammond; Tony P. Tang; Susan P. Rhodes; Andrew T. Metcalf; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos; Indrani W. Gunawardana
Tetrahedron Letters, ISSN: 00404039 18733581
Malcolm P. Huestis; Wendy Liu; Matthew Volgraf; Hans E. Purkey; Christine Yu; Weiru Wang; Darin Smith; Guy Vigers; Darrin Dutcher; Kevin W. Hunt; Michael Siu
Molecular Switches, Second Edition,
Matthew Volgraf; Matthew Banghart; Dirk Trauner
Education
- University of California, Berkeley, Ph.D in Chemistry – 2008
- University of Pennsylvania, B.A. in Chemistry – 2003
Awards & Honors
- ACS Medicinal Chemistry Division Young Investigator Symposium, Speaker – 2016
- American Cancer Society Postdoctoral Fellow – 2008-2010
- Roche Excellence in Chemistry Award – 2007
- ACS Medicinal Chemistry Division Predoctoral Fellowship – 2006