Minhong Yan
Senior Principal Scientist, Molecular Oncology
Postdoc Mentor
"It is extremely satisfying that our work has the potential to significantly impact patients' life."
24
Years at Genentech
45
Publications
I started to work at Genentech as a postdoc with Vishva Dixit in 1997 to investigate signaling pathways regulating cell survival and death. One of the important incentives to work at Genentech is being able to explore basic biology while conducting translation research and drug discovery. Working at Genentech has expanded my research to various fronts and disease areas.
Postdoctoral Mentor
I came to Genentech in 1997 as a postdoc in the laboratory of Vishva Dixit. My own career has benefited tremendously from our postdoc program that offers diverse resources and rich academic culture. Now as a postdoc mentor, I would like to provide my support to the research career development of current postdocs.
Featured Publication
Balancing efficacy and safety of an anti-DLL4 antibody through pharmacokinetic modulation.
Clin Cancer Res. 2016;22(6):1469-79
Couch J, Zhang G, Beyer J, Zuch de Zafra C, Gupta P, Kamath A3 Lewin-Koh N, Tarrant J, Allamneni K, Cain G, Yee S, Ross S, Cook R, Tsai SP, Ruppel J, Ridgway J, Paluch M, Hass P, Franklin J, Yan M.
EphB4-ephrinB2 forward but not reverse signaling regulates lymphatic valve development.
Nat Commun. 2015; 6:6625
Zhang G, Brady J, Liang WC, Wu Y, Henkemeyer M, Yan M.
My Focus
We are interested in signaling pathways that regulate vascular processes during vascular development and tumor angiogenesis. Research activities range from uncovering novel signaling components, investigating the molecular and cellular machinery that drives the vasculature alteration upon signaling disruption, exploring vascular biology using mouse models, to developing therapeutic strategies.
Publications
Immunity, ISSN: 10974180 10747613
Yi Zhou; Mingjian Fei; Gu Zhang; Wei-Ching Liang; Wei Yu Lin; Yan Wu; Robert Piskol; John B.B. Ridgway; Erin McNamara; Haochu Huang; Juan Zhang; Jaehak Oh; Jaina M. Patel; Diana Jakubiak; Jeffrey Lau; Beth Blackwood; Daniel D. Bravo; Yongchang Shi; Jianyong Wang; Hong-Ming Hu; Wyne P. Lee; Rajiv Jesudason; Dewakar Sangaraju; Zora Modrusan; Keith R. Anderson; Søren Warming; Merone Roose-Girma; Minhong Yan
mAbs, ISSN: 19420870 19420862
Chen; Maciej Paluch; Julie A. Zorn; Sharmila Rajan; Brandon Leonard; Alberto Estevez; John Brady; Chiu; Wilson Phung; Amin Famili; Minhong Yan; Claudio Ciferri; Marissa L. Matsumoto; Greg A. Lazar; Susan R. Crowell; Hass; Nick Agard
mAbs, ISSN: 19420870 19420862
Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Jovencio Borneo; Yan Wu; Minhong Yan
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Evan A Thackaberry; Yi Zhou; Christina L. Zuch de Zafra; Fuh; Chingwei V. Lee; Sarah Sanowar; John B.B. Ridgway; Aija Kusi; Cindy A. Farman; Helen Booler; Daniel Sheinson; Carol A. Rasmussen; Paul Miller; Eric Wakshull; Minhong Yan; Vlad Bantseev
Blood, ISSN: 15280020 00064971
Vedran Radojcic; Katelyn Paz; Jooho Chung; Jing Du; Eric Perkey; Ryan Flynn; Sanja Ivcevic; Michael Zaiken; Ann Friedman; Minhong Yan; Maria A. Pletneva; Stefanie Sarantopoulos; Christian W. Siebel; Bruce R. Blazar; Ivan Maillard
Circulation, ISSN: 15244539 00097322
Markus Jabs; Adam J. Rose; Lorenz H. Lehmann; Jacqueline Taylor; Iris Moll; Tjeerd P. Sijmonsma; Stefanie E. Herberich; Sven W. Sauer; Gernot Poschet; Giuseppina Federico; Carolin Mogler; Eva-Maria Weis; Hellmut G. Augustin; Minhong Yan; Norbert Gretz; Roland M. Schmid; Ralf H. Adams; Hermann-Joseph Gröne; Rüdiger Hell; Jürgen G. Okun; Johannes Backs; Peter P. Nawroth; Stephan Herzig; Andreas Fischer
Journal of Clinical Investigation, ISSN: 15588238 00219738
Jooho Chung; Christen Ebens; Eric Perkey; Vedran Radojcic; Ute Koch; Leonardo Scarpellino; Alexander Tong; Frederick Allen; Sherri Wood; Jiane Feng; Ann Friedman; David Granadier; Ivy T. Tran; Qian Chai; Lucas Onder; Minhong Yan; Pavan Reddy; Bruce R. Blazar; Alex Y. Huang; Todd V. Brennan; D. Keith Bishop; Burkhard Ludewig; Christian W. Siebel; Freddy Radtke; Sanjiv A. Luther; Ivan Maillard
Nature Communications, ISSN: 20411723
Roxana Ola; Alexandre Dubrac; Jinah Han; Feng Zhang; Jennifer S. Fang; Bruno Larrivee; Monica Lee; Ana Angulo; Jan R. Kraehling; Gael Genet; Karen K. Hirschi; William C. Sessa; Francesc V. Canals; Mariona Graupera; Minhong Yan; Lawrence H. Young; Paul S. Oh; Anne Eichmann
Clinical Cancer Research, ISSN: 15573265 10780432
Jessica A. Couch; Gu Zhang; Joseph Beyer; Christina de Zafra; Priyanka Gupta; Amrita Kamath; Nicholas Lewin-Koh; Jacqueline M. Tarrant; Krishna P. Allamneni; Cain; Sharon Fong Yee; Ross; Ryan Cook; Siao Ping Tsai; Jane Ruppel; John B.B. Ridgway; Maciej Paluch; Hass; Jayme N. Carter-Franklin; Minhong Yan
Nature Communications, ISSN: 20411723
Leonor Gama-Norton; Eva Ferrando; Cristina Ruiz-Herguido; Zenhy Liu; Jordi Guiu; Abul B.M.M.K. Islam; Sung-Uk Lee; Minhong Yan; Cynthia J. Guidos; Nuria López-Bigas; Takahiro Maeda; Lluis Espinosa; Raphael Kopan; Anna Bigas
Stem Cells, ISSN: 15494918 10665099
Weihuan Wang; Shuiliang Yu; Grant Zimmerman; Yiwei Wang; Jay Myers; Vionnie W. C. Yu; Dan Huang; Xiaoran Huang; Jeongsup Shim; Yuanshuai Huang; William Xin; Peter Qiao; Minhong Yan; Wei Xin; David T. Scadden; Pamela Stanley; John Lowe; Alex Y. Huang; Christian W. Siebel; Lan Zhou
Nature Communications, ISSN: 20411723
Gu Zhang; John B.B. Ridgway; Wei-Ching Liang; Yan Wu; Mark Henkemeyer; Minhong Yan
Journal of Immunology, ISSN: 15506606 00221767
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard
Journal of Immunology, ISSN: 15506606 00221767
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard
mAbs, ISSN: 19420870 19420862
Amrita Kamath; Victor Yip; Priyanka Gupta; C. Andrew Boswell; Daniela Bumbaca; Peter Haughney; Joni Castro; Siao Ping Tsai; Glenn Pacheco; Ross; Minhong Yan; Lisa A. Damico; Leslie A. Khawli; Shen
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hao Chen; John B.B. Ridgway; Tao Sai; Joyce Lai; Søren Warming; Hanying Chen; Merone Roose-Girma; Gu Zhang; Weinian Shou; Minhong Yan
Journal of Clinical Investigation, ISSN: 00219738 15588238
Ivy T. Tran; Ashley R. Sandy; Alexis J. Carulli; Christen Ebens; Jooho Chung; Gloria T. Shan; Vedran Radojcic; Ann Friedman; Thomas Gridley; Amy Shelton; Pavan Reddy; Linda C. Samuelson; Minhong Yan; Christian W. Siebel; Ivan Maillard
Blood, ISSN: 15280020 00064971
Sung-Uk Lee; Manami Maeda; Yuichi Ishikawa; Sierra Min Li; Anne Wilson; Adrian M. Jubb; Nagisa Sakurai; Lihong Weng; Emma Fiorini; Freddy Radtke; Minhong Yan; H. Robson MacDonald; Ching-Cheng Chen; Takahiro Maeda
Vascular Cell, ISSN: 2045824X
Minhong Yan
PLoS ONE, ISSN: 19326203
Na Yin; Nan Zhang; Girdhari Lal; Jiangnan Xu; Minhong Yan; Yaozhong Ding; Jonathan S. Bromberg
Blood, ISSN: 15280020 00064971
Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Ganesh Kolumam; Christian W. Siebel; Minhong Yan
Nature, ISSN: 00280836 14764687
Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John B.B. Ridgway; Dorreyah Schahin-Reed; Graham J. Dow; Amy Shelton; Scott Stawicki; Ryan J. Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Christopher Callahan; Sarah G. Hymowitz; Christian W. Siebel
Blood, ISSN: 15280020 00064971
Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Minhong Yan
Nature, ISSN: 00280836 14764687
Minhong Yan; Christopher Callahan; Joseph Beyer; Krishna P. Allamneni; Gu Zhang; John B.B. Ridgway; Kyle Niessen; Greg D. Plowman
Clinical Cancer Research, ISSN: 10780432
Minhong Yan; Greg D. Plowman
Nature, ISSN: 14764687 00280836
John B.B. Ridgway; Gu Zhang; Yan Wu; Scott Stawicki; Wei-Ching Liang; Yvan Chanthery; Joe Kowalski; Ryan J. Watts; Christopher Callahan; Ian Kasman; Mallika Singh; May Chien; Christine Tan; Hongo; Frederic J. De Sauvage; Greg D. Plowman; Minhong Yan
Journal of Biological Chemistry, ISSN: 00219258
Sarah G. Hymowitz; Darshana Patel; Heidi J. A. Wallweber; Steven T. Runyon; Minhong Yan; Jianping Yin; Stephanie K. Shriver; Nathaniel C. Gordon; Borlan Pan; Nicholas J. Skelton; Robert F. Kelley; Melissa A. Starovasnik
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; French; Minhong Yan; Gretchen D. Frantz; Vishva M. Dixit
Biochemistry, ISSN: 00062960
Nathaniel C. Gordon; Borlan Pan; Sarah G. Hymowitz; Jianping Yin; Robert F. Kelley; Andrea G Cochran; Minhong Yan; Vishva M. Dixit; Wayne J. Fairbrother; Melissa A. Starovasnik
Immunity, ISSN: 10747613
Dhaya Seshasayee; Patricia A. Valdez; Minhong Yan; Vishva M. Dixit; Daniel B. Tumas; Iqbal S. Grewal
Structure, ISSN: 09692126
Sarah G. Hymowitz; Deanne M. Compaan; Minhong Yan; Heidi J. A. Wallweber; Vishva M. Dixit; Melissa A. Starovasnik; De Vos
Antioxidants and Redox Signaling, ISSN: 15230864
Krista L. Seanor; Janet V. Cross; Suzanne M. Nguyen; Minhong Yan; Dennis J. Templeton
Immunity, ISSN: 10747613
Nobuhiko Kayagaki; Minhong Yan; Dhaya Seshasayee; Hua Wang; Wyne P. Lee; French; Iqbal S. Grewal; Andrea G Cochran; Nathaniel C. Gordon; Jianping Yin; Melissa A. Starovasnik; Vishva M. Dixit
Current Biology, ISSN: 09609822
Eduardo Moreno; Minhong Yan; Konrad Basler
Current Biology, ISSN: 09609822
Minhong Yan; Zemin Zhang; John B.B. Ridgway; Sarah Schilbach; Wayne J. Fairbrother; Vishva M. Dixit
Journal of Experimental Medicine, ISSN: 00221007
Haoran Zhao; Minhong Yan; Hua Wang; Sharon Erickson; Iqbal S. Grewal; Vishva M. Dixit
Current Biology, ISSN: 09609822
Minhong Yan; John B.B. Ridgway; Betty Chan; Wyne P. Lee; Benjamin Hsu; Susan Harless; Michael Cancro; Iqbal S. Grewal; Vishva M. Dixit
Nature Immunology, ISSN: 15292908
Hua Wang; Scot A. Marsters; Thad Baker; Betty Chan; Wyne P. Lee; Ling Fu; Daniel B. Tumas; Minhong Yan; Vishva M. Dixit; Avi Ashkenazi; Iqbal S. Grewal
Nature Immunology, ISSN: 15292908
Minhong Yan; Hua Wang; Betty Chan; Merone Roose-Girma; Sharon Erickson; Thad Baker; Daniel B. Tumas; Iqbal S. Grewal; Vishva M. Dixit
Science, ISSN: 00368075
Minhong Yan; Li-Chong Wang; Sarah G. Hymowitz; Sarah Schilbach; James Lee; Goddard; De Vos; Gao; Vishva M. Dixit
Current Biology, ISSN: 09609822
Scot A. Marsters; Minhong Yan; Pitti; Philip E. Haas; Vishva M. Dixit; Avi Ashkenazi
Nature Immunology, ISSN: 15292908
Minhong Yan; Scot A. Marsters; Iqbal S. Grewal; Hua Wang; Avi Ashkenazi; Vishva M. Dixit
Journal of Biological Chemistry, ISSN: 00219258
Minhong Yan; James Lee; Sarah Schilbach; Goddard; Vishva M. Dixit
Nature Genetics, ISSN: 10614036
Quangeng Zhang; Reiner Siebert; Minhong Yan; Bernd Hinzmann; Xiaoli Cui; Liquan Xue; Karen M. Rakestraw; Clayton W. Naeve; Georg Beckmann; Dennis D. Weisenburger; Warren G. Sanger; Hadwiga Nowotny; Michael Vesely; Evelyne Callet-Bauchu; Gilles Salles; Vishva M. Dixit; André Rosenthal; Brigitte Schlegelberger; Stephan W. Morris
Journal of Biological Chemistry, ISSN: 00219258
Hans-Peter Gerber; Amy E. McMurtrey; Joe Kowalski; Minhong Yan; Keyt; Vishva M. Dixit; Napoleone Ferrara
Education
- Case Western Reserve University, Molecular and Cellular Biology, Ph.D – 1997
- Shanghai Institute of Biochemistry, Chinese Academy of Science, M.S. – 1991
- Eastern China University of Technology, Biochemistry, B.S. – 1988
