Minhong Yan
Principal Scientist, Molecular Oncology
Postdoc Mentor
"It is extremely satisfying that our work has the potential to significantly impact patients' life."
23
Years at Genentech
38
Publications
I started to work at Genentech as a postdoc with Vishva Dixit in 1997 to investigate signaling pathways regulating cell survival and death. One of the important incentives to work at Genentech is being able to explore basic biology while conducting translation research and drug discovery. Working at Genentech has expanded my research to various fronts and disease areas.
Postdoctoral Mentor
I came to Genentech in 1997 as a postdoc in the laboratory of Vishva Dixit. My own career has benefited tremendously from our postdoc program that offers diverse resources and rich academic culture. Now as a postdoc mentor, I would like to provide my support to the research career development of current postdocs.
Featured Publication
Balancing efficacy and safety of an anti-DLL4 antibody through pharmacokinetic modulation.
Clin Cancer Res. 2016;22(6):1469-79
Couch J, Zhang G, Beyer J, Zuch de Zafra C, Gupta P, Kamath A3 Lewin-Koh N, Tarrant J, Allamneni K, Cain G, Yee S, Ross S, Cook R, Tsai SP, Ruppel J, Ridgway J, Paluch M, Hass P, Franklin J, Yan M.
EphB4-ephrinB2 forward but not reverse signaling regulates lymphatic valve development.
Nat Commun. 2015; 6:6625
Zhang G, Brady J, Liang WC, Wu Y, Henkemeyer M, Yan M.
My Focus
We are interested in signaling pathways that regulate vascular processes during vascular development and tumor angiogenesis. Research activities range from uncovering novel signaling components, investigating the molecular and cellular machinery that drives the vasculature alteration upon signaling disruption, exploring vascular biology using mouse models, to developing therapeutic strategies.
Publications
Harnessing MerTK agonism for targeted therapeutics
mAbs, ISSN: 19420862
Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Joven Borneo; Yan Wu; Minhong Yan
Blood, ISSN: 15280020
Vedran Radojcic; Katelyn Paz; Jooho Chung; Jing Du; Eric Perkey; Ryan Flynn; Sanja Ivcevic; Michael Zaiken; Ann Friedman; Minhong Yan; Maria A. Pletneva; Stefanie Sarantopoulos; Chris Siebel; Bruce R. Blazar; Ivan Maillard
Journal of Clinical Investigation, ISSN: 15588238
Jooho Chung; Christen Ebens; Eric Perkey; Vedran Radojcic; Ute Koch; Leonardo Scarpellino; Alexander Tong; Frederick Allen; Sherri Wood; Jiane Feng; Ann Friedman; David Granadier; Ivy T. Tran; Qian Chai; Lucas Onder; Minhong Yan; Pavan Reddy; Bruce R. Blazar; Alex Y. Huang; Todd V. Brennan; D. Keith Bishop; Burkhard Ludewig; Chris Siebel; Freddy Radtke; Sanjiv A. Luther; Ivan Maillard
Clinical Cancer Research, ISSN: 15573265
Jessica Couch; Gu Zhang; Joe Beyer; Christina de Zafra; Priyanka Gupta; Amrita Kamath; Nicholas Lewin-Koh; Jacqueline Tarrant; Krishna Allamneni; Gary Cain; Sharon Yee; Sarajane Ross; Ryan Cook; Siao Ping Tsai; Jane Ruppel; John Brady; Maciej Paluch; Phil Hass; Jayme Franklin; Minhong Yan
Nature Communications, ISSN: 20411723
Leonor Gama-Norton; Eva Ferrando; Cristina Ruiz-Herguido; Zenhy Liu; Jordi Guiu; Abul B.M.M.K. Islam; Sung-Uk Lee; Minhong Yan; Cynthia J. Guidos; Nuria López-Bigas; Takahiro Maeda; Lluis Espinosa; Raphael Kopan; Anna Bigas
Nature Communications, ISSN: 20411723
Gu Zhang; John Brady; Wei-Ching Liang; Yan Wu; Mark Henkemeyer; Minhong Yan
Journal of Immunology, ISSN: 15506606
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Chris Siebel; D. Keith Bishop; Ivan Maillard
Stem Cells, ISSN: 15494918
Weihuan Wang; Shuiliang Yu; Grant Zimmerman; Yiwei Wang; Jay Myers; Vionnie W. C. Yu; Dan Huang; Xiaoran Huang; Jeongsup Shim; Yuanshuai Huang; William Xin; Peter Qiao; Minhong Yan; Wei Xin; David T. Scadden; Pamela Stanley; John Lowe; Alex Y. Huang; Chris Siebel; Lan Zhou
mAbs, ISSN: 19420870
Amrita Kamath; Victor Yip; Priyanka Gupta; Andy Boswell; Daniela Yadav; Peter Haughney; Joni Castro; Siao Ping Tsai; Glenn Pacheco; Sarajane Ross; Minhong Yan; Lisa Damico-Beyer; Leslie Khawli; Ben-Quan Shen
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Hao Chen; John Brady; Tao Sai; Joyce Lai; Soren Warming; Hanying Chen; Meron Roose-Girma; Gu Zhang; Weinian Shou; Minhong Yan
Journal of Clinical Investigation, ISSN: 00219738
Ivy T. Tran; Ashley R. Sandy; Alexis J. Carulli; Christen Ebens; Jooho Chung; Gloria T. Shan; Vedran Radojcic; Ann Friedman; Thomas Gridley; Amy Shelton; Pavan Reddy; Linda C. Samuelson; Minhong Yan; Chris Siebel; Ivan Maillard
Blood, ISSN: 00064971
Sung-Uk Lee; Manami Maeda; Yuichi Ishikawa; Sierra Min Li; Anne Wilson; Adrian Jubb; Nagisa Sakurai; Lihong Weng; Emma Fiorini; Freddy Radtke; Minhong Yan; H. Robson MacDonald; Ching-Cheng Chen; Takahiro Maeda
Vascular Cell, ISSN: 2045824X
Minhong Yan
PLoS ONE, ISSN: 19326203
Na Yin; Nan Zhang; Girdhari Lal; Jiangnan Xu; Minhong Yan; Yaozhong Ding; Jonathan S. Bromberg
Blood, ISSN: 00064971
Kyle Niessen; Gu Zhang; John Brady; Hao Chen; Ganesh Kolumam; Chris Siebel; Minhong Yan
Nature, ISSN: 00280836
Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John Brady; Dorreyah Schahin-Reed; Graham Dow; Amy Shelton; Scott Stawicki; Ryan Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Chris Callahan; Sarah Hymowitz; Chris Siebel
Blood, ISSN: 00064971
Kyle Niessen; Gu Zhang; John Brady; Hao Chen; Minhong Yan
Nature, ISSN: 00280836
Minhong Yan; Chris Callahan; Joe Beyer; Krishna Allamneni; Gu Zhang; John Brady; Kyle Niessen; Greg Plowman
Clinical Cancer Research, ISSN: 10780432
Minhong Yan; Greg Plowman
Nature, ISSN: 14764687
John Brady; Gu Zhang; Yan Wu; Scott Stawicki; Wei-Ching Liang; Yvan Chanthery; Joe Kowalski; Ryan Watts; Chris Callahan; Ian Kasman; Mallika Singh; May Chien; Christine Tan; Jo-Anne Hongo; Frederic De Sauvage; Greg Plowman; Minhong Yan
Journal of Biological Chemistry, ISSN: 00219258
Sarah Hymowitz; Darshana Patel; Heidi Ackerly Wallweber; Steven Runyon; Minhong Yan; Peter Yin; Stephanie Shriver; Nathaniel Gordon; Borlan Pan; Nicholas Skelton; Robert Kelley; Melissa Starovasnik
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; Dorothy French; Minhong Yan; Gretchen Frantz; Vishva Dixit
Structure, ISSN: 09692126
Sarah Hymowitz; Deanne Compaan; Minhong Yan; Heidi Ackerly Wallweber; Vishva Dixit; Melissa Starovasnik; De Vos
Biochemistry, ISSN: 00062960
Nathaniel Gordon; Borlan Pan; Sarah Hymowitz; Peter Yin; Robert Kelley; Andrea Cochran; Minhong Yan; Vishva Dixit; Wayne Fairbrother; Melissa Starovasnik
Immunity, ISSN: 10747613
Dhaya Seshasayee; Patricia Valdez; Minhong Yan; Vishva Dixit; Daniel B. Tumas; Iqbal S. Grewal
Antioxidants and Redox Signaling, ISSN: 15230864
Krista L. Seanor; Janet V. Cross; Suzanne M. Nguyen; Minhong Yan; Dennis J. Templeton
Immunity, ISSN: 10747613
Nobuhiko Kayagaki; Minhong Yan; Dhaya Seshasayee; Hua Wang; Wyne Lee; Dorothy French; Iqbal S. Grewal; Andrea Cochran; Nathaniel Gordon; Peter Yin; Melissa Starovasnik; Vishva Dixit
Current Biology, ISSN: 09609822
Minhong Yan; Zhen Zhang; John Brady; Sarah Schilbach; Wayne Fairbrother; Vishva Dixit
Journal of Experimental Medicine, ISSN: 00221007
Helen Zhao; Minhong Yan; Hua Wang; Sharon Erickson; Iqbal S. Grewal; Vishva Dixit
Current Biology, ISSN: 09609822
Minhong Yan; John Brady; Betty Chan; Wyne Lee; Benjamin Hsu; Susan Harless; Michael Cancro; Iqbal S. Grewal; Vishva Dixit
Nature Immunology, ISSN: 15292908
Hua Wang; Scot Marsters; Thad W. Baker; Betty Chan; Wyne Lee; Ling Fu; Daniel B. Tumas; Minhong Yan; Vishva Dixit; Avi Ashkenazi; Iqbal S. Grewal
Nature Immunology, ISSN: 15292908
Minhong Yan; Hua Wang; Betty Chan; Meron Roose-Girma; Sharon Erickson; Thad W. Baker; Daniel B. Tumas; Iqbal S. Grewal; Vishva Dixit
Science, ISSN: 00368075
Minhong Yan; Li-Chong Wang; Sarah Hymowitz; Sarah Schilbach; James Lee; Audrey Goddard; De Vos; Gao; Vishva Dixit
Current Biology, ISSN: 09609822
Scot Marsters; Minhong Yan; Bob Pitti; David Haase; Vishva Dixit; Avi Ashkenazi
Nature Immunology, ISSN: 15292908
Minhong Yan; Scot Marsters; Iqbal S. Grewal; Hua Wang; Avi Ashkenazi; Vishva Dixit
Journal of Biological Chemistry, ISSN: 00219258
Minhong Yan; James Lee; Sarah Schilbach; Audrey Goddard; Vishva Dixit
Nature Genetics, ISSN: 10614036
Quangeng Zhang; Reiner Siebert; Minhong Yan; Bernd Hinzmann; Xiaoli Cui; Liquan Xue; Karen M. Rakestraw; Clayton W. Naeve; Georg Beckmann; Dennis D. Weisenburger; Warren G. Sanger; Hadwiga Nowotny; Michael Vesely; Evelyne Callet-Bauchu; Gilles Salles; Vishva Dixit; André Rosenthal; Brigitte Schlegelberger; Stephan W. Morris
Journal of Biological Chemistry, ISSN: 00219258
Hans-Peter Gerber; Amy E. McMurtrey; Joe Kowalski; Minhong Yan; Bruce A. Keyt; Vishva Dixit; Napoleone Ferrara
Education
- Case Western Reserve University, Molecular and Cellular Biology, Ph.D – 1997
- Shanghai Institute of Biochemistry, Chinese Academy of Science, M.S. – 1991
- Eastern China University of Technology, Biochemistry, B.S. – 1988
