"My passion is to accelerate the development of novel therapeutics to get the drugs to patients faster and potentially help improve their lives."
I joined Genentech in 2012 to support the early stage development of Active Pharmaceutical Ingredients and Drug products. I lead the analytical chemistry efforts to develop proper and efficient characterization methods to guide process chemistry synthetic route development and drug product formulation processes. Furthermore, we support the manufacturing of clinical supplies, validate analytical methods, conduct release testing, and write analytical sections of Health Authority regulatory filing documents.
My group is also responsible for constantly evaluating and developing new technologies to improve efficiency and High throughput analysis. My research interests include ultra-fast separations and two-dimensional chromatographic techniques. I am really excited to work at Genentech since it is a science-driven company and supports science and innovation.
Our group focuses on using the state-of-art analytical techniques to assess the physical and chemical properties of active pharmaceutical ingredients and drug products ( e.g. tablets, capsules, IV, inhalation formulations…etc). We use a variety of techniques to understand reaction mechanisms and kinetics, and drug dissolution and absorption behaviors. We also ensure the quality of the drugs that will be used in clinical and non-clinical studies and develop approaches to establish appropriate drug shelf-life durations.
My research interests include ultra-fast separation techniques such as Super Critical Fluid Chromatography (SFC) and Ultra-High Pressure Liquid Chromatography (UHPLC). For high throughput separations and complex mixture analysis, we have utilized and developed two-dimensional chromatographic and mass spectroscopic (MS) techniques such as 2D-LC-MS and 2D LC-SFC-MS.