Morgan Sheng - Vice President, Neuroscience

Morgan Sheng

Vice President, Neuroscience

Postdoc Mentor
"As a neuroscientist with a medical background, I am inspired to understand how the brain works from the level of molecule to cognitive behavior, and to tackle serious brain diseases based on understanding of biological mechanisms."
Years at Genentech
Awards & Honors

I started at Genentech in September 2008. Prior to that, I spent 14 years in academia focused on molecular and cellular neuroscience - first at Massachusetts General Hospital/Harvard Medical School and then at Massachusetts Institute of Technology (MIT), where I was the Menicon Professor of Neuroscience and an Investigator of the Howard Hughes Medical Institute. Before I got into research I completed a residency in general medicine in London, U.K. So I have seen human disease from two sides - as a scientist investigating basic mechanisms and as a medical doctor treating patients.

I came to Genentech because I believe this company is best equipped to translate our increasing knowledge of the basic causes of disease into potential treatments for serious brain disorders. I am energized by the people at Genentech, who have the right combination of know-how, creativity and motivation to make a difference for patients.

Postdoctoral Mentor

I have mentored over 30 postdocs and PhD students at Harvard, MIT and Genentech. Most have gone on to successful careers in academia (MGH/Harvard, Broad Institute, UCSD, Vanderbilt, Georgetown, Wisconsin, Erasmus (Netherlands), International Institute of Molecular and Cell Biology in Warsaw (Poland), CNR, Milano (Italy), Univ Munich (Germany), London Univ (UK), KAIST (Korea), Academia Sinica (Taiwan)), as well as the biotech industry (Amgen, Biogen, Vertex, Otsuka, Denali, etc). Presently there are 5 postdocs and 1 Senior Research Associate in my lab.

Featured Publication

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

Neuron. 2016 Jul 20;91(2):328-40.

Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M.