Patrick Lupardus - Senior Scientist, Structural Biology

Patrick Lupardus

Senior Scientist, Structural Biology

Postdoc Mentor
"Structural biology has a vital and exciting position in drug discovery: we help our scientists visualize how and why their molecules work the way they do."
Years at Genentech
Awards & Honors

I started my scientific career at the University of Wisconsin, followed by a move to the San Francisco Bay area for graduate and postdoctoral studies at Stanford University. I worked in neurobiology and cell biology labs before finally settling on biochemistry and structural biology as my scientific calling. For as long as I can remember I’ve been interested in kinase signaling pathways, starting with the ATR replication stress signaling pathway as a graduate student, followed by a dive into cytokine signaling pathways as a postdoctoral fellow. As a postdoc I was drawn to work on cytokine signaling because of the significance of these pathways in cancer and autoimmune diseases. I came to Genentech to put my knowledge and skills to use in helping understand how our drugs work at a molecular level.

Since joining Genentech in 2010 I’ve worked on diverse small molecule and antibody projects in immunology, cancer immunotherapy, neurobiology and infectious disease, while continuing pursuit of a molecular understanding of cytokine signaling. I feel extremely lucky to have found a place where my work is exciting and important, my colleagues are unbelievably talented, and I get to learn something new about biology and drug discovery every day.

Featured Publication

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2.

Nature Structural and Molecular Biology, 2014, 21(5):443–448.

Wallweber, H. J. A., Tam, C., Franke, Y., Starovasnik, M. A., & Lupardus, P. J.