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Rami Hannoush - Senior Principal Scientist, Early Discovery Biochemistry

Rami Hannoush

Senior Principal Scientist, Early Discovery Biochemistry

Postdoc Mentor
"My passion is to investigate and solve key problems in biomedical science with the hope that it translates our discoveries into ground-breaking therapeutics that can have an impact on patients’ lives."
Years at Genentech
Awards & Honors

I joined the Early Discovery Biochemistry department at Genentech in 2006 after completing my postdoctoral fellowship at Harvard and my PhD degree at McGill University.

My current role includes leading interdisciplinary teams in lead discovery and research biology, with the overarching goal of developing therapeutics for the treatment of diseases with unmet medical need. I have a deep and broad interest in science and translational research, and Genentech offers me a unique opportunity to conduct ground-breaking science and at the same time translate our discoveries into the clinic.

Post Doctoral Mentor
The postdoc program at Genentech is a glorious enterprise for fostering creativity, bringing in trainees early in their careers to grow and develop into the next-generation scientists. The postdoc program is strategically positioned within the Genentech ecosystem, with access to terrific resource infrastructure and a wide range of scientific expertise. I really enjoy the opportunity to work together and mentor a postdoctoral trainee to learn to think independently and critically, and to come up with innovative approaches to solve scientific problems. Projects in my lab are aimed at understanding and investigating biological mechanisms in basic biomedical science that can have a profound impact on drug discovery and development. The lab has made important contributions in the fields of Wnt signaling, protein lipidation and targeting protein functions in cancer and neurodegenerative disease.

Featured Publication

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.

Proc Natl Acad Sci U S A. 2017, 114, 4147-4152.

Nile AH, Mukund S, Stanger K, Wang W, Hannoush RN.