Richard Bourgon - Director and Senior Scientist, Bioinformatics & Computational Biology

Richard Bourgon

Director and Senior Scientist, Bioinformatics & Computational Biology

"Advances in high-throughput genomic assay technologies and the computational techniques necessary for their productive use have created unique opportunities—for pursuing personalized approaches to cancer therapy and for better understanding the complex molecular basis of the disease."
Years at Genentech

In 2006, I obtained a Ph.D. in Statistics at the University of California, Berkeley, under the mentorship of Terry Speed, and I was one of the early participants in a new, cross-disciplinary designated emphasis program in computational biology. I went on to join the European Bioinformatics Institute as a staff scientist, investigating technical aspects of microarray and next-generation sequencing data analysis with Wolfgang Huber, and applying these technologies to study fundamental aspects of meiotic recombination and inheritance, in collaboration with Lars Steinmetz at the European Molecular Biology Laboratory.

I joined Genentech in 2010, applying my technical background to the study of prognostic and predictive cancer biomarkers. My initial work was in pre-clinical model systems; however, recent methodological advances have enabled application of the same technologies to clinical trial sample collections, and I now collaborate closely with scientists in both Research Molecular Oncology and Oncology Biomarker Development.

Featured Publication

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Nature. 2018 Feb 22;554(7693):544-548.

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel Iii EE, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.