Robert Graham - Senior Scientist, OMNI Human Genetics

Robert Graham

Senior Scientist, OMNI Human Genetics

Postdoc Mentor
10
Years at Genentech
52
Publications
4
Awards & Honors

I came to Genentech in 2007 with the goal of applying human genetics to identify pathways associated with disease and response to therapies. The sequencing of the human genome and subsequent rapid advances in genotyping and high-throughput sequencing technologies allow fundamental questions about the role of human genetics in complex diseases to be asked.

The Human Genetics group is focused on utilizing the latest advances in genotyping, DNA sequencing, population genetics and bioinformatics to understand disease biology and discover novel therapeutic targets.

Postdoctoral Mentor

Being a mentor to a post-doctoral fellow is one of the most rewarding experiences as a Scientist at Genentech. In my lab, we are currently working on understanding the biology of rare human variants that we have identified that increase risk of or protect from Alzheimer’s disease and Parkinson’s disease. Using a range of in vitro techniques, as well as creating animal models, we hope to better understand the mechanism behind how these human variants impact disease risk.

Featured Publication

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

Nat Med. 2014 Dec;20(12):1452-7.

Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR.