"Working at Genentech is a dream come true; you are in the midst of talented, passionate and extremely bright scientists who constantly motivate and inspire you to accomplish more. I feel fortunate to have the opportunity to implement clinical pharmacology and quantitative strategies and in bringing potential new treatment options to the forefront of patient care."
I have over 18 years of experience in the discovery and development of large and small molecules, including antibody-drug conjugates (ADCs/TDCs) with a focus on clinical pharmacology, translational sciences, pharmacokinetics (PK), pharmacodynamics (PD) and toxicokinetics (TK). As Director of Oncology, my group currently provides global clinical pharmacology support for all oncology molecules in our portfolio, both marketed and those in various stages of clinical development. During my 10-year tenure at Genentech, I have held varying levels of seniority starting out as a scientist/individual contributor on project teams, senior scientist, pharmacology sub team cross functional leader, clinical pharmacology group leader and Associate Director.
Prior to Genentech, I was a Senior Scientist with Novartis and Genesoft Pharmaceuticals where I provided strategic support in drug discovery and development for oncology and infectious diseases. I have also been a study director and a co-principal investigator for pharmacokinetics and drug metabolism studies at Stanford Research Institute (SRI) International.
Clin Pharmacokinet. 2013 Aug;52(8):657-72.
Curr Drug Metab. 2012 Sep 1;13(7):901-10.
As the Director of Oncology, Clinical Pharmacology our group provides strategic clinical pharmacology support for all oncology molecules in our portfolio, including small molecules, monoclonal antibodies and antibody drug conjugates (ADCs/TDCs), cancer immunotherapy and heme-oncology molecules. In collaboration with clinical scientists and other researchers we continue to implement conventional, adaptive and innovative Phase I/II and III trial designs to inform drug development and enable decision making. Our group also oversees the regulatory submissions in support of new drug/biologics approval which includes the clinical pharmacology aspects of the submission and the prescribing information. We ensure that preclinical and research data are appropriately integrated with clinical pharmacology data and right dose/schedule/route decisions are made in support of the new drug entity or new platforms (eg. ADC or T-cell dependent bispecifics). We also take pride in characterizing the pharmacokinetics (drug disposition, absorption, metabolism and elimination) of drugs and integrating state of the art modeling strategies to better understand drug exposure and response (safety/efficacy) relationships and determining any dose adjustments needed for special populations (eg, pediatrics, elderly, organ impairment, ethnicity etc) for various projects across multiple therapeutic areas. Additionally, our group is passionate about implementing quantitative approaches to drug development for novel combinations including cancer immunotherapy and heme-oncology molecules.