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Scientists / Our Scientists

Sarah Hymowitz

Vice President & Principal Scientist, Protein Sciences

Postdoc Mentor

"I am motivated by the hope that our work may someday help patients. I am inspired by the talents and insights of my colleagues."

Years at Genentech

Publications

Awards & Honors

I started at Genentech as a postdoctoral fellow in 1999 studying the structure and function of members of the TNF super family of ligands and receptors. I was attracted to Genentech by the excellent science and the collaborative environment. In my current role, I have the privilege of working with colleagues on discovery, large molecule and small molecule projects. The Protein Science departments are responsible for the discovery of reagent and therapeutic antibodies. We also create biological reagents and data that further our understanding of the structure, function, and regulation of proteins of therapeutic interest and collaboratively enable the discovery of novel large molecule and small molecule therapeutics.

Featured Publication

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.

Cancer Cell. 2016 Apr 11;29(4):477-493.

Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S.

View Abstract

My area of expertise is X-ray crystallography. We study the structure and interactions of macromolecules with ligands. These ligands can be receptors, small molecules or Fab fragments of antibodies. This information assists in the discovery of potential therapeutics and contributes to a better fundamental understanding of signaling events of importance to human disease.

Active research projects include kinase signaling complexes, receptor-ligand interactions, structural biology of ubiquitin signaling and antibody-antigen complexes.

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

mAbs, ISSN: 19420862

Cholpon Tilegenova; Saeed Izadi; Peter Yin; Christine Huang; Jiansheng Wu; Diego Ellerman; Sarah Hymowitz; Benjamin Walters; Cleo Salisbury; Paul Carter

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Nicholas P. D. Liau; Timothy J. Wendorff; John Quinn; Micah Steffek; Wilson Phung; Peter Liu; Jia Tang; Flaviyan J. Irudayanathan; Saeed Izadi; Andrey S. Shaw; Shiva Malek; Sarah Hymowitz; Sudhamsu Sudhamsu

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Sarah Hymowitz

Vice President & Principal Scientist, Protein Sciences

Featured Publication

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.

Portraits in Science

Strength in Numbers

Proteins: Seeing is Believing