"I am motivated by the hope that our work may someday help patients. I am inspired by the talents and insights of my colleagues."
I started at Genentech as a postdoctoral fellow in 1999 studying the structure and function of members of the TNF super family of ligands and receptors. I was attracted to Genentech by the excellent science and the collaborative environment. In my current role, I have the privilege of working with colleagues on discovery, large molecule and small molecule projects. The Protein Science departments are responsible for the discovery of reagent and therapeutic antibodies. We also create biological reagents and data that further our understanding of the structure, function, and regulation of proteins of therapeutic interest and collaboratively enable the discovery of novel large molecule and small molecule therapeutics.
Cancer Cell. 2016 Apr 11;29(4):477-493.
My area of expertise is X-ray crystallography. We study the structure and interactions of macromolecules with ligands. These ligands can be receptors, small molecules or Fab fragments of antibodies. This information assists in the discovery of potential therapeutics and contributes to a better fundamental understanding of signaling events of importance to human disease.
Active research projects include kinase signaling complexes, receptor-ligand interactions, structural biology of ubiquitin signaling and antibody-antigen complexes.