Sarah Hymowitz
Vice President & Principal Scientist, Protein Sciences
Postdoc Mentor
"I am motivated by the hope that our work may someday help patients. I am inspired by the talents and insights of my colleagues."
21
Years at Genentech
61
Publications
4
Awards & Honors
I started at Genentech as a postdoctoral fellow in 1999 studying the structure and function of members of the TNF super family of ligands and receptors. I was attracted to Genentech by the excellent science and the collaborative environment. In my current role, I have the privilege of working with colleagues on discovery, large molecule and small molecule projects. The Protein Science departments are responsible for the discovery of reagent and therapeutic antibodies. We also create biological reagents and data that further our understanding of the structure, function, and regulation of proteins of therapeutic interest and collaboratively enable the discovery of novel large molecule and small molecule therapeutics.
Featured Publication
Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell. 2016 Apr 11;29(4):477-493.
Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S.
My Focus
My area of expertise is X-ray crystallography. We study the structure and interactions of macromolecules with ligands. These ligands can be receptors, small molecules or Fab fragments of antibodies. This information assists in the discovery of potential therapeutics and contributes to a better fundamental understanding of signaling events of importance to human disease.
Active research projects include kinase signaling complexes, receptor-ligand interactions, structural biology of ubiquitin signaling and antibody-antigen complexes.
Publications
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
mAbs, ISSN: 19420862
Cholpon Tilegenova; Saeed Izadi; Peter Yin; Christine Huang; Jiansheng Wu; Diego Ellerman; Sarah Hymowitz; Benjamin Walters; Cleo Salisbury; Paul Carter
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Sarah Hymowitz; Shiva Malek
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette Castanedo; Jason Burch; Leo Berezhkovskiy; Hans Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter Fan; Jianwen Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent McKenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren Wu; Yamin Zhang; Zoe Zhong; Steven Staben
Structure, ISSN: 18784186 09692126
Christine Huang; Nina Oberbeck; Yi-Chun Hsiao; Peter Liu; Adam Johnson; Vishva Dixit; Sarah Hymowitz
Journal of Medicinal Chemistry, ISSN: 15204804
Georgette Castanedo; Nicole Blaquiere; Maureen Beresini; Brandon Bravo; Hans Brightbill; Jacob Chen; Haifeng Cui; Charles Eigenbrot; Christine Everett; Jianwen Feng; Robert Godemann; Emily Gogol; Sarah Hymowitz; Adam Johnson; Nobuhiko Kayagaki; Pawan Bir Kohli; Kathleen Knüppel; Joachim Kraemer; Susan Krüger; Pui Loke; Paul A. McEwan; Christian A.G.N. Montalbetti; David Allen; Myron Smith; Stefan Steinbacher; Swathi Sujatha-Bhaskar; Ryan Takahashi; Xiaolu Wang; Lawren Wu; Yamin Zhang; Steven Staben
Cancer Cell, ISSN: 18783686
Scott Foster; Dan Whalen; Ayşegül Özen; Matthew Wongchenko; Peter Yin; Ivana Yen; Gabriele Schaefer; John D. Mayfield; Juliann Chmielecki; Philip J. Stephens; Lee A. Albacker; Yibing Yan; Kyung Song; Georgia Hatzivassiliou; Charles Eigenbrot; Christine Yu; Andrey Shaw; Gerard Manning; Nicholas Skelton; Sarah Hymowitz; Shiva Malek
Structure, ISSN: 18784186
Paola Di Lello; Sarah Hymowitz
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Steven L. Gallion; Sarah Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Greg Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
ACS Medicinal Chemistry Letters, ISSN: 19485875
Olivier Rene; Benjamin Fauber; Gladys Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah Hymowitz; Adam Johnson; James Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi Ackerly Wallweber; Harvey Wong
ACS Medicinal Chemistry Letters, ISSN: 19485875
Zhi-Fu Tao; Lisa Hasvold; Le Wang; Xilu Wang; Andrew M. Petros; Chang H. Park; Erwin R. Boghaert; Nathaniel D. Catron; Jun Chen; Colman; Czabotar; Kurt Deshayes; Wayne Fairbrother; John Flygare; Sarah Hymowitz; Sha Jin; Russell A. Judge; Michael Koehler; Peter J. Kovar; Guillaume Lessene; Michael J. Mitten; Chudi Ndubaku; Paul M. Nimmer; Hans Purkey; Anatol Oleksijew; Darren C. Phillips; Brad E Sleebs; Smith; Morey L. Smith; Stephen K. Tahir; Keith G Watson; Yu Xiao; John C. Xue; Haichao Zhang; Kerry Zobel; Saul H. Rosenberg; Chris Tse; Joel D. Leverson; Steven W. Elmore; Andrew J. Souers
Structure, ISSN: 18784186
Dan Whalen; Sarah Hymowitz
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Benjamin Fauber; Olivier Rene; Gladys Boenig; Brenda Burton; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah Hymowitz; Adam Johnson; Hank La; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Weiru Wang; Harvey Wong
Cancer Cell, ISSN: 18783686
Jacob Haling; Jawahar Sudhamsu; Ivana Yen; Steve Sideris; Wendy Sandoval; Wilson Phung; Brandon Bravo; Tony Giannetti; Ariana Peck; Alexandre Masselot; Tony Morales; Darin Smith; Barbara J. Brandhuber; Sarah Hymowitz; Shiva Malek
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Benjamin Fauber; Gladys Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah Hymowitz; Adam Johnson; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Olivier Rene; Harvey Wong
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jawahar Sudhamsu; Peter Yin; Eugene Chiang; Melissa Starovasnik; Jane Grogan; Sarah Hymowitz
Science, ISSN: 10959203
Andy Huang; James C. McGann; Bob Liu; Rami Hannoush; Jennie Lill; Victoria Pham; Kim Newton; Mike Kakunda; Jinfeng Liu; Christine Yu; Sarah Hymowitz; Jo-Anne Hongo; Anthony Wynshaw-Boris; Paul Polakis; Richard M. Harland; Vishva Dixit
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Nature Medicine, ISSN: 10788956
Andrew J. Souers; Joel D. Leverson; Erwin R. Boghaert; Scott L. Ackler; Nathaniel D. Catron; Jun Chen; Brian D. Dayton; Hong Ding; Sari H. Enschede; Wayne Fairbrother; David C.S. Huang; Sarah Hymowitz; Sha Jin; Seong Lin Khaw; Peter J. Kovar; Lloyd T. Lam; Jackie Lee; Heather Maecker; Kennan C. Marsh; Kylie D. Mason; Michael J. Mitten; Paul M. Nimmer; Anatol Oleksijew; Chang H. Park; Cheol-Min Park; Darren C. Phillips; Andrew W. Roberts; Deepak Sampath; John F. Seymour; Morey L. Smith; Gerard M. Sullivan; Stephen K. Tahir; Chris Tse; Michael D. Wendt; Yu Xiao; John C. Xue; Haichao Zhang; Rod A. Humerickhouse; Saul H. Rosenberg; Steven W. Elmore
Structure, ISSN: 09692126
Gladys Boenig; Krista Bowman; JW Feng; Terry Crawford; Christine Everett; Yvonne Franke; Angela Oh; Mark Stanley; Steven Staben; Melissa Starovasnik; Heidi Ackerly Wallweber; Jiansheng Wu; Lawren Wu; Adam Johnson; Sarah Hymowitz
Science, ISSN: 10959203
Anwesha Dey; Dhaya Seshasayee; Raj Noubade; Dorothy French; Jinfeng Liu; Mira S. Chaurushiya; Don Kirkpatrick; Victoria Pham; Jennie Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva Dixit
Journal of Medicinal Chemistry, ISSN: 00222623
John Flygare; Maureen Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Fred Cohen; Kurt Deshayes; Karl Doerner; Gail Eckhardt; Linda Orren; Bainian Feng; Matthew C. Franklin; Stacy Reisner; Lewis Gazzard; Jason Halladay; Sarah Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley Murray; Emile Plise; Clifford Quan; Daniel Stephan; Young Shin; Jeffrey Tom; Vickie Tsui; Joann M. Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi Ackerly Wallweber; Lan Wang; Joseph Ware; Kobe Wen; Harvey Wong; Jonathan Wong; Melisa Wong; Susan Wong; Ron Yu; Kerry Zobel; Wayne Fairbrother
Journal of Molecular Biology, ISSN: 00222836
Marissa Matsumoto; Ken Dong; Christine Yu; Lilian Phu; Xinxin Gao; Rami Hannoush; Sarah Hymowitz; Don Kirkpatrick; Vishva Dixit; Robert Kelley
Nature Structural and Molecular Biology, ISSN: 15459993
Oscar Huang; Xiaolei Ma; Peter Yin; Jeremy Flinders; Till Maurer; Nobuhiko Kayagaki; Qui Phung; Ivan Bosanac; David Arnott; Vishva Dixit; Sarah Hymowitz; Melissa Starovasnik; Andrea Cochran
Science, ISSN: 10959203
Erin Dueber; Allyn Schoeffler; Andreas Lingel; Mike Elliott; Anna Fedorova; Tony Giannetti; Kerry Zobel; Brigitte Maurer; Eugene Varfolomeev; Ping Wu; Heidi Ackerly Wallweber; Sarah Hymowitz; Kurt Deshayes; Domagoj Vucic; Wayne Fairbrother
Structure, ISSN: 09692126
Ken Dong; Elizabeth Helgason; Christine Yu; Lilian Phu; David Arnott; Ivan Bosanac; Deanne Compaan; Oscar Huang; Anna Fedorova; Don Kirkpatrick; Sarah Hymowitz; Erin Dueber
Journal of Molecular Biology, ISSN: 00222836
Ivan Bosanac; Lilian Phu; Borlan Pan; Inna Zilberleyb; Brigitte Maurer; Vishva Dixit; Sarah Hymowitz; Don Kirkpatrick
Annual Review of Immunology, ISSN: 07320582
Wenjun Ouyang; Sascha Rutz; Natasha Crellin; Patricia Valdez; Sarah Hymowitz
Cancer Cell, ISSN: 15356108
Nicholas Andrew Wilson; Becky Yang; Annie Weaver; Stefanie Loeser; Scot Marsters; David Lawrence; Yun Li; Bob Pitti; Klara Totpal; Sharon Yee; Sarajane Ross; Jean-Michel Vernes; Yanmei Lu; Camellia Adams; Rienk Offringa; Bob Kelley; Sarah Hymowitz; Dylan Daniel; Gloria Meng; Avi Ashkenazi
Nature Chemical Biology, ISSN: 15524450
Julie Di Paolo; Tao Huang; Mercedesz Balazs; Jim Barbosa; Kai Barck; Brandon Bravo; Rick Carano; James Darrow; Douglas R. Davies; Laura DeForge; Lauri Diehl; Ronald Ferrando; Steven L. Gallion; Tony Giannetti; Peter Gribling; Vincent Hurez; Sarah Hymowitz; Randall Jones; Jeffrey E. Kropf; Wyne Lee; Patricia M. MacIejewski; Scott A. Mitchell; Hong Rong; Bart L. Staker; J. Andrew Whitney; Sherry Yeh; Wendy Young; Christine Yu; Juan Zhang; Karin Reif; Kevin S. Currie
Handbook of Cell Signaling, 2/e,
Hao Wu; Sarah Hymowitz
Molecular Cell, ISSN: 10972765
Ivan Bosanac; Ingrid Wertz; Borlan Pan; Christine Yu; Saritha Kusam; Cynthia Lam; Lilian Phu; Qui Phung; Brigitte Maurer; David Arnott; Don Kirkpatrick; Vishva Dixit; Sarah Hymowitz
Nature Structural and Molecular Biology, ISSN: 15459993
Sarah Hymowitz; Vishva Dixit
Genes and Development, ISSN: 15495477
Philip A. Beachy; Sarah Hymowitz; Bob Lazarus; Daniel J. Leahy; Christian Siebold
Journal of Biological Chemistry, ISSN: 00219258
Henry Maun; Peggy Wen; Andreas Lingel; Frederic De Sauvage; Bob Lazarus; Suzie Scales; Sarah Hymowitz
Molecular Cell, ISSN: 10972765
Marissa Matsumoto; Kate Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy Bustos; Lilian Phu; Don Kirkpatrick; Sarah Hymowitz; Michael Rape; Robert Kelley; Vishva Dixit
Nature Reviews Cancer, ISSN: 1474175X
Sarah Hymowitz; Ingrid Wertz
Nature, ISSN: 00280836
Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John Brady; Dorreyah Schahin-Reed; Graham Dow; Amy Shelton; Scott Stawicki; Ryan Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Chris Callahan; Sarah Hymowitz; Chris Siebel
Journal of Molecular Biology, ISSN: 00222836
Nathaniel Gordon; Samantha Lien; Jerry Johnson; Heidi Ackerly Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Clifford Quan; Melissa Starovasnik; Sarah Hymowitz; Robert Kelley
ACS Chemical Biology, ISSN: 15548929
Chudi Ndubaku; Eugene Varfolomeev; Lan Wang; Kerry Zobel; Kevin Lau; Linda Orren; Brigitte Maurer; Anna Fedorova; Jasmin Dynek; Michael Koehler; Sarah Hymowitz; Vickie Tsui; Kurt Deshayes; Wayne Fairbrother; John Flygare; Domagoj Vucic
Nature Structural and Molecular Biology, ISSN: 15459993
Ivan Bosanac; Henry Maun; Suzie Scales; Peggy Wen; Andreas Lingel; Fernando Bazan; Frederic De Sauvage; Sarah Hymowitz; Bob Lazarus
Cell, ISSN: 00928674
Kim Newton; Marissa Matsumoto; Ingrid Wertz; Don Kirkpatrick; Jennie Lill; Jenille Tan; Debbie Dugger; Nathaniel Gordon; Sachdev Sidhu; Frederic A. Fellouse; László Kömüves; Dorothy French; Ronald Ferrando; Cynthia Lam; Deanne Compaan; Christine Yu; Ivan Bosanac; Sarah Hymowitz; Robert Kelley; Vishva Dixit
Cell Death and Differentiation, ISSN: 13509047
Camellia Adams; Klara Totpal; David Lawrence; Scot Marsters; Bob Pitti; Sharon Yee; Sarajane Ross; Laura DeForge; Hartmut Koeppen; Meredith Sagolla; Deanne Compaan; Henry Lowman; Sarah Hymowitz; Avi Ashkenazi
Journal of Clinical Investigation, ISSN: 00219738
Dhaya Seshasayee; Wyne Lee; Meijuan Zhou; Jean Shu; Eric Suto; Juan Zhang; Lauri Diehl; Cary Austin; Gloria Meng; Martha Tan; Sherry Bullens; Stefan Seeber; Maria E. Fuentes; Aran F. Labrijn; Yvo M. F. Graus; Lisa Miller; Edward S. Schelegle; Dallas M. Hyde; Lawren Wu; Sarah Hymowitz; Flavius Martin
Journal of Biological Chemistry, ISSN: 00219258
Eric Bourhis; Sarah Hymowitz; Andrea Cochran
Nature Medicine, ISSN: 10788956
Klaus Wagner; Elizabeth Punnoose; Tom Januario; David Lawrence; Bob Pitti; Kate Lancaster; Dori Lee; Melissa Von Goetz; Sharon Yee; Klara Totpal; Ling-Yuh Huw; Viswanatham Katta; Guy Cavet; Sarah Hymowitz; Lukas Amler; Avi Ashkenazi
Blood, ISSN: 00064971
Vivian Lee; Sarah Hymowitz; Heidi Ackerly Wallweber; Nathaniel Gordon; Karen Billeci; Siao Ping Tsai; Deanne Compaan; Peter Yin; Qian Gong; Robert Kelley; Laura DeForge; Flavius Martin; Melissa Starovasnik; Germaine Fuh
Journal of Molecular Biology, ISSN: 00222836
Bing Li; Russell; Deanne Compaan; Klara Totpal; Scot Marsters; Avi Ashkenazi; Andrea Cochran; Sarah Hymowitz; Sachdev Sidhu
Cell Death and Differentiation, ISSN: 14765403
Eimon; Erica Kratz; Eugene Varfolomeev; Sarah Hymowitz; Howard Stern; Jiping Zha; Avi Ashkenazi
Structure, ISSN: 09692126
Deanne Compaan; Sarah Hymowitz
Analytical Biochemistry, ISSN: 00032697
Victoria Pham; William J. Henzel; David Arnott; Sarah Hymowitz; Wendy Sandoval; Bao-Tran Truong; Henry Lowman; Jennie Lill
Journal of Biological Chemistry, ISSN: 00219258
Deanne Compaan; Lino Gonzalez; Irene Tom; Kelly Loyet; Dan Eaton; Sarah Hymowitz
Journal of Molecular Biology, ISSN: 00222836
Frederic A. Fellouse; Bing Li; Deanne Compaan; Andrew A. Peden; Sarah Hymowitz; Sachdev Sidhu
Journal of Biological Chemistry, ISSN: 00219258
Sarah Hymowitz; Darshana Patel; Heidi Ackerly Wallweber; Steven Runyon; Minhong Yan; Peter Yin; Stephanie Shriver; Nathaniel Gordon; Borlan Pan; Nicholas Skelton; Robert Kelley; Melissa Starovasnik
Journal of Biological Chemistry, ISSN: 00219258
Robert Kelley; Klara Totpal; Stephanie H. Lindstrom; Mary Mathieu; Karen Billeci; Laura DeForge; Roger Pai; Sarah Hymowitz; Avi Ashkenazi
Nature Chemical Biology, ISSN: 15524469
Sarah Hymowitz; Avi Ashkenazi
Journal of Molecular Biology, ISSN: 00222836
Heidi Ackerly Wallweber; Deanne Compaan; Melissa Starovasnik; Sarah Hymowitz
Structure, ISSN: 09692126
Sarah Hymowitz; Deanne Compaan; Minhong Yan; Heidi Ackerly Wallweber; Vishva Dixit; Melissa Starovasnik; De Vos
Handbook of Cell Signaling,
Sarah Hymowitz; De Vos
Biochemistry, ISSN: 00062960
Nathaniel Gordon; Borlan Pan; Sarah Hymowitz; Peter Yin; Robert Kelley; Andrea Cochran; Minhong Yan; Vishva Dixit; Wayne Fairbrother; Melissa Starovasnik
EMBO Journal, ISSN: 02614189
Sarah Hymowitz; Ellen Filvaroff; Peter Yin; James Lee; Liping Cai; Risser; Ellen M. Maruoka; Weiguang Mao; Jessica Foster; Robert Kelley; Guohua G. Pan; Austin L. Gurney; De Vos; Melissa Starovasnik
Science, ISSN: 00368075
Minhong Yan; Li-Chong Wang; Sarah Hymowitz; Sarah Schilbach; James Lee; Audrey Goddard; De Vos; Gao; Vishva Dixit
Molecular Cell, ISSN: 10972765
Sarah Hymowitz; Hans Christinger; Germaine Fuh; Mark Ultsch; Mark O'Connell; Robert Kelley; Avi Ashkenazi; De Vos
Education
- University of California, San Francisco, Graduate Group in Biophysics, Ph.D. – 1998
- Swarthmore College, Department of Chemistry, B.A. – 1992
Awards & Honors
- Named one of Bay Area “Most Influential Women in Business” by San Francisco Business Times – 2017
- Clemens Prize for Outstanding Thesis in Biophysics – 1998
- Chancellor's Dissertation Year Fellowship – 1997-1998
- National Science Foundation Pre-doctoral Fellowship – 1992-1995