Shan Chung
Senior Principal Scientist and Director, Bioanalytical Sciences
Postdoc Mentor
"Curiosity breeds innovation."
16
Years at Genentech
24
Publications at Genentech
3
Awards & Honors
Shan Chung is currently a Director and Principal Scientist in the Department of BioAnalytical Sciences (BAS), gRED. Shan received his Ph.D. in Molecular Biology from University of Pennsylvania and completed his postdoctoral training in Protein Engineering at Harvard University. Shan has more than 20 years’ experience in research and development of pharmaceutical products, specifically in the areas of preclinical and clinical development of therapeutic antibodies. An expert on Fc effector functions, bioanalytical assays, and immunogenicity of biotherapeutics, Shan serves on the USP Fc Function Expert Panel, and is an active member of the AAPS Working Group on Immunogenicity Risk Assessment and Mitigation. Shan joined Genentech in 2006, and currently leads the Effector Function and Cell Biology group in BAS.
Postdoctoral Mentor
I enjoy the opportunity to work with postdocs on exploratory/research projects which often adds additional excitement and innovation to my work.
Featured Publication
An in vitro FcRn-dependent transcytosis assay as a screening tool for predictive assessment of non-specific clearance of antibody therapeutics in humans.
mAbs 11(5):942-955.
Chung, S., V. Nguyen, L. Lin, et al.
A Novel Method for Determining Antibody-Dependent Cellular Phagocytosis.
J. Immunol Methods 468:55-60.
Kamen, L., E. Kho, C. Langsdorf, B. Ordonia, T. Thakurta, and S. Chung.
Characterization of in vitro ADCC activity of therapeutic antibodies - impact of effector cells.
J Immunol Methods, 407: 63–75.
Chung, S., Y. L. Lin, C. Reed, C. Ng, Z. J. Cheng, F. Malavasi, J. Yang, V. Quarmby, and A. Song.
My Focus
The responsibilities of my group include biological characterization of clinical candidates, development and validation of bioanalytical assays, and evaluation of immunogenicity potential and pharmacokinetics liability of antibody products.
Genentech Publications
Methods in Molecular Biology, ISSN: 19406029 10643745
Lynn Kamen; Benjamin A. Ordonia; Srividya Myneni; Shan Chung
Methods in Molecular Biology, ISSN: 19406029 10643745
Shan Chung; Yuwen L. Lin; Van Nguyen; Chang Liu
mAbs, ISSN: 19420870 19420862
Sivan Cohen; Shan Chung; Christoph Spiess; Victor Lundin; Stefanich; Steven T. Laing; Vanessa Clark; Jochen Brumm; Ying Zhou; Catherine Huang; Joyce Guerrero; Srividya Myneni; Rajbharan Yadav; Ketevan A. Siradze; Kun Peng
mAbs, ISSN: 19420870 19420862
Sivan Cohen; Srividya Myneni; Anna Batt; Joyce Guerrero; Jochen Brumm; Shan Chung
British Journal of Pharmacology, ISSN: 14765381 00071188
Dongwei Li; Donna W. Lee; Randall Dere; Bing Zheng; Shang-Fan Yu; Franklin Fuh; Katherine R. Kozak; Shan Chung; Daniela Bumbaca Yadav; Denise Nazzal; Dimitry Danilenko; MaryAnn Go; Marna Williams; Andrew G. Polson; Kirsten Achilles Poon; Saileta Prabhu
mAbs, ISSN: 19420870 19420862
Shan Chung; Van Nguyen; Yuwen L. Lin; Julien Lafrance-Vanasse; Suzie J. Scales; Kevin Lin; Rong Deng; Kathi Williams; Gizette Sperinde; Juan Jenny Li; Kai Zheng; Siddharth Sukumaran; Devin B. Tesar; James A. Ernst; Saloumeh Kadkhodayan Fischer; Greg A. Lazar; Saileta Prabhu; An Song
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Srividya Myneni; Chris Langsdorf; Elviza Kho; Benjamin A. Ordonia; Tara Thakurta; Kai Zheng; An Song; Shan Chung
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Tara Thakurta; Srividya Myneni; Kai Zheng; Shan Chung
Pharmaceutical Biotechnology: Fundamentals and Applications,
Rong Deng; C. Andrew Boswell; Wendy Putnam; Meina Tao Tang; Amit Garg; Chunze Li; Shan Chung; Sandhya Girish
Frontiers in Pharmacology, ISSN: 16639812
Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Erickson; Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler
Bioanalysis, ISSN: 17576199 17576180
Lauren Stevenson; Richards; Renuka Pillutla; Albert Torri; John Kamerud; Devangi Mehta; Steve Keller; Shobha Purushothama; Boris Gorovits; Virginia Litwin; Christopher C. Stebbins; Joseph Marini; Chris Beaver; Gizette Sperinde; Patricia Siguenza; Roland F Staack; Yongchang Qiu; Lakshmi Amaravadi; Shashi Amur; Catherine Aversa Fleener; Daniel Baltrukonis; Ian Catlett; Elana Cherry; Shan Chung; Isabelle Cludts; Lorella Di Donato; Saloumeh Kadkhodayan Fischer; Stephanie Fraser; Fabio Garofolo; Cherie Green; George R. Gunn; Sam Haidar; Jonathan Haulenbeek; Neil Henderson; Shirley Hopper; Akiko Ishii-Watabe; Rafiqul Islam; Brian Janelsins; Vibha Jawa; Vellalore Kakkanaiah; Szilard Kamondi; Gerry Kolaitis; Robert J Kubiak; Seema Kumar; Pekka Kurki; Meina Liang; Patrick Liu; Kimberly Maxfield; Heather Myler; Nisha Palackal; Rachel Palmer; Joao Pedras-Vasconcelos; Steven Piccoli; Paul Rhyne; Yoshiro Saito; Natasha Savoie; Eginhard Schick; Becky Schweighardt; Judy Shih; An Song; Priya Sriraman; Ludovicus Staelens; Giane Sumner; Yongliang Sun; Martin Ullmann; Verthelyi; Meenu Wadhwa; Yow-Ming C. Wang; Yuanxin Xu; Haoheng Yan; Tong-Yuan Yang; Rong Zeng
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Van Nguyen; Lynn Kamen; Kai Zheng; Bianca Vora; An Song
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Megan Lo; Hok Seon Kim; Raymond K. Tong; Travis W. Bainbridge; Jean-Michel Vernes; Yin Zhang; Yuwen L. Lin; Shan Chung; Dennis; Y. Joy Yu Zuchero; Ryan J. Watts; Jessica A. Couch; Meng; Jasvinder K. Atwal; Randall J. Brezski; Christoph Spiess; James A. Ernst
British Journal of Pharmacology, ISSN: 14765381 00071188
Franklin Fuh; Looney; Dongwei Li; Kirsten Achilles Poon; Randall Dere; Dimitry Danilenko; Jacqueline McBride; Chae Reed; Shan Chung; Bing Zheng; W Rodney Mathews; Andrew G. Polson; Saileta Prabhu; Marna Williams
Journal of Immunological Methods, ISSN: 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
AAPS Journal, ISSN: 15507416
Bonnie Wu; Shan Chung; Xu-Rong Jiang; Jim McNally; Joao Pedras-Vasconcelos; Renuka Pillutla; Joleen T. White; Yuanxin Xu; Shalini Gupta
AAPS Journal,
Bonnie Wu; Shan Chung; Xu-Rong Jiang; Jim McNally; Joao Pedras-Vasconcelos; Renuka Pillutla; Joleen T. White; Yuanxin Xu; Shalini Gupta
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Chae Reed; Carl Ng; Zhijie Jey Cheng; Fabio Malavasi; Yang; Quarmby; An Song
mAbs, ISSN: 19420870 19420862
Whitney Shatz; Shan Chung; Bing Li; Brett Marshall; Max L. Tejada; Wilson Phung; Wendy N. Sandoval; Robert F. Kelley; Justin M. Scheer
mAbs, ISSN: 19420862 19420870
Marcella Yu; Darren Brown; Chae Reed; Shan Chung; Jeff Lutman; Stefanich; Anne Wong; Jean-Philippe Stephan; Robert Bayer
mAbs, ISSN: 19420862 19420870
Shan Chung; Quarmby; Xiaoying Gao; Yong Ying; Yuwen L. Lin; Chae Reed; Chris Fong; Wendy Lau; Zhihua Julia Qiu; Amy Shen; Vanderlaan; An Song
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Boxu Yan; Daniel Boyd; Timothy Kaschak; Joni Tsukuda; Amy Shen; Yuwen L. Lin; Shan Chung; Priyanka Gupta; Amrita Kamath; Anne Wong; Jean-Michel Vernes; Meng; Klara Totpal; Gabriele Schaefer; Guoying Jiang; Bartek Nogal; Craig Emery; Vanderlaan; Paul J. Carter; Reed J. Harris; Ashraf Amanullah
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Xu-Rong Jiang; An Song; Svetlana Bergelson; Thomas Arroll; Bhavin S. Parekh; Kimberly May; Shan Chung; Robert Strouse; Mire-Sluis; Mark Schenerman
Education
- University of Pennsylvania, Ph.D. in Molecular Biology – 1990
- Auburn University, M.S. in Immunology – 1985
- National Taiwan University, B.S. in Zoology – 1980
Awards & Honors
- SBIR phase II Award, NINDS, NIH – 1999
- SBIR phase I Award, NINDS, NIH – 1997
- National Multiple Sclerosis Society Postdoctoral Fellowship Award – 1991 - 1994