Shiva Malek

As Principal Scientist in the Department of Discovery Oncology, my lab is interested in two main areas of biology: non-catalytic functions of protein kinases and pseudokinases such as BRAF and KSR and regulation of MAPK signaling in RAS-mutant tumors. We utilize a variety of approaches to address these problems including in vivo models of disease, in vitro biochemical and cellular studies, small molecule kinase inhibitors, chemical biology approaches including proteomics studies (in collaboration with Dr. Don Kirkpatrick) and structure-function studies. To understand the mechanistic principles of scaffolding functions of protein kinases at a structural level, my lab collaborates closely with several other labs at Genentech including Dr. Sarah Hymowitz’s lab in the Structural Biology Department.

• University of California, San Diego, Ph.D., Biochemistry – 2000
• University of California, Irvine, M.S., Chemistry – 1995
• University of California, Los Angeles, B.S., Biochemistry – 1993

• Genentech Women’s Professional Emerging Leader – 2013
• Pre-doctoral Fellowship – 1998-2000
• Molecular Biophysics Training Grant – 1996-1998
• Outstanding Teaching Assistant – 1996-1997
• Graduate Research Traineeship – 1994-1995
• Outstanding Research Award in Biochemistry – 1993
• Outstanding Research Proposal, UCLA Association of Chemists and Biochemists – 1991