Genentech: Shuguang Ma | Principal Scientist, Drug Metabolism & Pharmacokinetics

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Scientists / Our Scientists

"I'm inspired in discovering and developing potential new drugs to treat serious diseases with unmet medical needs."

9

Years at Genentech

25

Publications

I joined Genentech in 2011 as a Scientist after worked 10 years at other pharmaceutical and biotechnology companies. I currently lead the development biotransformation group in support of small molecule drug development. We focus on characterizing the absorption, distribution, metabolism, elimination properties of small molecule drug candidates using state-of-the-art and innovative technologies. I feel incredibly fortunate to have the opportunity working at such a great place with very talented and passionate scientists.

Featured Publication

Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST).

Drug Metab Lett. 2017 Nov 17;11(1):21-28.

Takahashi RH, Khojasteh C, Wright M, Hop CECA, Ma S.

Our group focuses on providing key data on determining the rate and route of drug elimination, characterizing the structures of drug metabolites in circulation and excreta, and determining absorption and fraction of metabolism using radiolabeled drugs.

My areas of research interests include the development of novel LC/MS-based techniques for metabolite detection and investigation of biotransformation and bioactivation of xenobiotics.

Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling

Drug Metabolism and Disposition, ISSN: 1521009X

Ryan Takahashi; Jessica M. Grandner; Sudheer Bobba; Yanzhou Liu; Paul Beroza; Donglu Zhang; Shuguang Ma

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor

British Journal of Clinical Pharmacology, ISSN: 03065251

Shuguang Ma; Julia Suchomel; Evelyn Yanez; Edward Yost; Xiaorong Liang; Rui Zhu; Hoa Le; Nicholas Siebers; Lori Joas; Roland Morley; Stephanie Royer Joo; Andrea Pirzkall; Laurent Salphati; Joseph A. Ware; Kari M. Morrissey

Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study

Drug Metabolism Letters, ISSN: 18723128

Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma

CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339

Drug Metabolism and Disposition, ISSN: 00909556

Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma

Novel mechanism of decyanation of GDC-0425 by cytochrome P450

Drug Metabolism and Disposition, ISSN: 1521009X

Ryan Takahashi; Jason Halladay; Mike Siu; Yuan Chen; Marcel Hop; Cyrus Khojasteh; Shuguang Ma

Mixed matrix method provides a reliable metabolite exposure comparison for assessment of metabolites in safety testing (MIST)

Drug Metabolism Letters, ISSN: 18723128

Ryan Takahashi; Cyrus Khojasteh; Matthew Wright; Marcel Hop; Shuguang Ma

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Xenobiotica, ISSN: 13665928

Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Marcel Hop; Cyrus Khojasteh; Edna Choo

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

ACS Medicinal Chemistry Letters, ISSN: 19485875

Hans Purkey; Kirk Robarge; Jinhua Chen; Zhongguo Chen; Laura Corson; Charles Z. Ding; Antonio DiPasquale; Peter Dragovich; Charles Eigenbrot; Marie Evangelista; Benjamin Fauber; Zhenting Gao; Hongxiu Ge; Anna Hitz; Qunh Ho; Sharada Labadie; Kwong Wah Lai; Wenfeng Liu; Yajing Liu; Chiho Li; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Steve Sideris; Mark Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Huihui Zhang; Aihe Zhou

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Nature Chemical Biology, ISSN: 15524469

Aaron Boudreau; Hans Purkey; Anna Hitz; Kirk Robarge; David Peterson; Sharada Labadie; Mandy Kwong; Rebecca Hong Thibodeau; Min Gao; Christopher Delnagro; Raju Pusapati; Shuguang Ma; Laurent Salphati; Jodie Pang; Aihe Zhou; Tommy Lai; Yingjie Li; Zhongguo Chen; Binqing Wei; Ivana Yen; Steve Sideris; Mark McCleland; Ron Firestein; Laura Corson; Alex Vanderbilt; Simon Williams; Anneleen Daemen; Marcia Belvin; Charles Eigenbrot; Peter Jackson; Shiva Malek; Georgia Hatzivassiliou; Deepak Sampath; Marie Evangelista; Thomas O'Brien

Non-cytochrome P450-mediated bioactivation and its toxicological relevance

Drug Metabolism Reviews, ISSN: 10979883

Jinping Gan; Shuguang Ma; Donglu Zhang

Elucidating the mechanism of tofacitinib oxidative decyanation

Drug Metabolism Letters, ISSN: 18723128

Hoa Le; Peter Fan; Susan Wong; Shuguang Ma; James Driscoll; Marcel Hop; Cyrus Khojasteh

The use of stable isotope-labeled drug as microtracers with conventional LC-MS/MS to support human absolute bioavailability studies: are we there yet?

Bioanalysis, ISSN: 17576199 17576180

Shuguang Ma; Swapan K. Chowdhury

Absorption, metabolism, excretion, and the contribution of intestinal metabolism to the oral disposition of [14C]cobimetinib, a MEK inhibitor, in humans

Drug Metabolism and Disposition, ISSN: 1521009X

Ryan Takahashi; Edna Choo; Shuguang Ma; Susan Wong; Jason Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Marcel Hop; Cyrus Khojasteh; Mark Dresser; Luna Musib

Short communication elucidating the mechanisms of formation for two unusual cytochrome P450-mediated fused ring metabolites of GDC-0623, a MAPK/ERK kinase inhibitor

Drug Metabolism and Disposition, ISSN: 1521009X

Ryan Takahashi; Shuguang Ma; Sarah Robinson; Qin Yue; Edna Choo; Cyrus Khojasteh

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: Contributions by P450, AO, and P-gp

European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 21070180

Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Joe Lyssikatos; Kelly Regal; Kevin W. Hunt; Nicholas C. Kallan; Mike Siu; Marcel Hop; Xingrong Liu; Cyrus Khojasteh

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin Fauber; Jason Boggs; Laura Corson; Charles Z. Ding; Charles Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans Purkey; Kirk Robarge; Laurent Salphati; Steve Sideris; Mark Ultsch; Erica VanderPorten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Peter Dragovich; Benjamin Fauber; Jason Boggs; Jinhua Chen; Laura Corson; Charles Z. Ding; Charles Eigenbrot; Hongxiu Ge; Tony Giannetti; Thomas Hunsaker; Sharada Labadie; Chiho Li; Yichin Liu; Yingchun Liu; Shuguang Ma; Shiva Malek; David Peterson; Keith Pitts; Hans Purkey; Kirk Robarge; Laurent Salphati; Steve Sideris; Mark Ultsch; Erica VanderPorten; Jing Wang; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

Investigations into the mechanisms of pyridine ring cleavage in vismodegibs

Drug Metabolism and Disposition, ISSN: 00909556

Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette Castanedo; Jacob Chen; Joe Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Marcel Hop; Harvey Wong

A tiered approach to address regulatory drug metabolite-related issues in drug development

Bioanalysis, ISSN: 17576199

Shuguang Ma; Swapan K. Chowdhury

Elucidating the mechanism of cytochrome p450-mediated pyrimidine ring conversion to pyrazole metabolites with the bace1 inhibitor gne-892 in ratss

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Ryan Takahashi; Shuguang Ma; Alan Deese; Qin Yue; Heasook Kim-Kang; Yijun Yi; Mike Siu; Kevin W. Hunt; Nicholas C. Kallan; Marcel Hop; Xingrong Liu; Cyrus Khojasteh

For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

Toxicology Research, ISSN: 20454538

Chenghong Zhang; Shuguang Ma; Erlie Delarosa; Suzanne Brown; Jasleen K. Sodhi; Vivek Musinipally; Patricia Chang; Rama Pai; Jason Halladay; Misner; Jane Kenny; Marcel Hop; Cyrus Khojasteh

Measuring NAD+ levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS

Bioanalysis, ISSN: 17576199

Xiaorong Liang; Lulu Yang; Ann Qin; Justin Ly; Bianca Liederer; Kirsten Messick; Shuguang Ma; Mark Zak; Peter Dragovich; Brian Dean; Marcel Hop; Yuzhong Deng

Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS

Bioanalysis, ISSN: 17576180

Shuguang Ma; Swapan K. Chowdhury

Screening Reactive Metabolites: Role of Liquid Chromatography-High-Resolution Mass Spectrometry in Combination with "Intelligent" Data Mining Tools

Mass Spectrometry for Drug Discovery and Drug Development,

Shuguang Ma; Swapan K. Chowdhury

Application of LC-high-resolution MS with 'intelligent' data mining tools for screening reactive drug metabolites

Bioanalysis, ISSN: 17576180

Shuguang Ma; Swapan K. Chowdhury

Purdue University, Ph.D in Analytical Chemistry – 1998
University of Minnesota, MS in Chemistry – 1994
Donghua University, BS in Environmental Engineering – 1991