Shuguang Ma
Senior Principal Scientist (Technology), Drug Metabolism & Pharmacokinetics
"I'm inspired in discovering and developing potential new drugs to treat serious diseases with unmet medical needs."
10
Years at Genentech
28
Publications
I joined Genentech in 2011 as a Scientist after worked 10 years at other pharmaceutical and biotechnology companies. I currently lead the development biotransformation group in support of small molecule drug development. We focus on characterizing the absorption, distribution, metabolism, elimination properties of small molecule drug candidates using state-of-the-art and innovative technologies. I feel incredibly fortunate to have the opportunity working at such a great place with very talented and passionate scientists.
Featured Publication
Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST).
Drug Metab Lett. 2017 Nov 17;11(1):21-28.
Takahashi RH, Khojasteh C, Wright M, Hop CECA, Ma S.
My Focus
Our group focuses on providing key data on determining the rate and route of drug elimination, characterizing the structures of drug metabolites in circulation and excreta, and determining absorption and fraction of metabolism using radiolabeled drugs.
My areas of research interests include the development of novel LC/MS-based techniques for metabolite detection and investigation of biotransformation and bioactivation of xenobiotics.
Publications
Xenobiotica, ISSN: 13665928 00498254
Qin Yue; S. Cyrus Khojasteh; Sungjoon Cho; Shuguang Ma; Teresa Mulder; John Chen; Jodie Pang; Xiao Ding; Alan Deese; Jackson D. Pellet; Nicholas Siebers; Lori Joas; Laurent Salphati; Joseph A. Ware
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
Drug Metabolism and Disposition,
Hao Cai; Victor Yip; Violet Lee; Sylvia Wong; Ola Saad; Shuguang Ma; Nina Ljumanovic; S Cyrus Khojasteh; Amrita Kamath; Ben-Quan Shen
Chemical Research in Toxicology, ISSN: 15205010
Chenghong Zhang; James Crawford; Matthew L. Landry; Huifen Chen; Jane Kenny; S Cyrus Khojasteh; Wendy Lee; Shuguang Ma; Wendy B. Young
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Jessica M. Grandner; Sudheer Bobba; Yanzhou Liu; Paul Beroza; Donglu Zhang; Shuguang Ma
Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor
British Journal of Clinical Pharmacology, ISSN: 03065251
Shuguang Ma; Julia Suchomel; Evelyn Yanez; Edward Yost; Xiaorong Liang; Rui Zhu; Hoa Le; Nicholas Siebers; Lori Joas; Roland Morley; Stephanie Royer Joo; Andrea Pirzkall; Laurent Salphati; Joseph A. Ware; Kari M. Morrissey
CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339
Drug Metabolism and Disposition, ISSN: 00909556
Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Jason Halladay; Mike Siu; Yuan Chen; Marcel Hop; Cyrus Khojasteh; Shuguang Ma
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Cyrus Khojasteh; Matthew Wright; Marcel Hop; Shuguang Ma
Xenobiotica, ISSN: 13665928
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Marcel Hop; Cyrus Khojasteh; Edna Choo
ACS Medicinal Chemistry Letters, ISSN: 19485875
Hans Purkey; Kirk Robarge; Jinhua Chen; Zhongguo Chen; Laura Corson; Charles Z. Ding; Antonio DiPasquale; Peter Dragovich; Charles Eigenbrot; Marie Evangelista; Benjamin Fauber; Zhenting Gao; Hongxiu Ge; Anna Hitz; Qunh Ho; Sharada Labadie; Kwong Wah Lai; Wenfeng Liu; Yajing Liu; Chiho Li; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Steve Sideris; Mark Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Huihui Zhang; Aihe Zhou
Drug Metabolism Reviews, ISSN: 10979883
Jinping Gan; Shuguang Ma; Donglu Zhang
Nature Chemical Biology, ISSN: 15524469
Aaron Boudreau; Hans Purkey; Anna Hitz; Kirk Robarge; David Peterson; Sharada Labadie; Mandy Kwong; Rebecca Hong Thibodeau; Min Gao; Christopher Delnagro; Raju Pusapati; Shuguang Ma; Laurent Salphati; Jodie Pang; Aihe Zhou; Tommy Lai; Yingjie Li; Zhongguo Chen; Binqing Wei; Ivana Yen; Steve Sideris; Mark McCleland; Ron Firestein; Laura Corson; Alex Vanderbilt; Simon Williams; Anneleen Daemen; Marcia Belvin; Charles Eigenbrot; Peter Jackson; Shiva Malek; Georgia Hatzivassiliou; Deepak Sampath; Marie Evangelista; Thomas O'Brien
Drug Metabolism Letters, ISSN: 18723128
Hoa Le; Peter Fan; Susan Wong; Shuguang Ma; James Driscoll; Marcel Hop; Cyrus Khojasteh
Bioanalysis, ISSN: 17576199 17576180
Shuguang Ma; Swapan K. Chowdhury
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Edna Choo; Shuguang Ma; Susan Wong; Jason Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Marcel Hop; Cyrus Khojasteh; Mark Dresser; Luna Musib
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Shuguang Ma; Sarah Robinson; Qin Yue; Edna Choo; Cyrus Khojasteh
European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 21070180
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Joe Lyssikatos; Kelly Regal; Kevin W. Hunt; Nicholas C. Kallan; Mike Siu; Marcel Hop; Xingrong Liu; Cyrus Khojasteh
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin Fauber; Jason Boggs; Laura Corson; Charles Z. Ding; Charles Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans Purkey; Kirk Robarge; Laurent Salphati; Steve Sideris; Mark Ultsch; Erica VanderPorten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Peter Dragovich; Benjamin Fauber; Jason Boggs; Jinhua Chen; Laura Corson; Charles Z. Ding; Charles Eigenbrot; Hongxiu Ge; Tony Giannetti; Thomas Hunsaker; Sharada Labadie; Chiho Li; Yichin Liu; Yingchun Liu; Shuguang Ma; Shiva Malek; David Peterson; Keith Pitts; Hans Purkey; Kirk Robarge; Laurent Salphati; Steve Sideris; Mark Ultsch; Erica VanderPorten; Jing Wang; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
Drug Metabolism and Disposition, ISSN: 00909556
Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette Castanedo; Jacob Chen; Joe Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Marcel Hop; Harvey Wong
Bioanalysis, ISSN: 17576199
Shuguang Ma; Swapan K. Chowdhury
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Alan Deese; Qin Yue; Heasook Kim-Kang; Yijun Yi; Mike Siu; Kevin W. Hunt; Nicholas C. Kallan; Marcel Hop; Xingrong Liu; Cyrus Khojasteh
Toxicology Research, ISSN: 20454538
Chenghong Zhang; Shuguang Ma; Erlie Delarosa; Suzanne Brown; Jasleen K. Sodhi; Vivek Musinipally; Patricia Chang; Rama Pai; Jason Halladay; Misner; Jane Kenny; Marcel Hop; Cyrus Khojasteh
Bioanalysis, ISSN: 17576199
Xiaorong Liang; Lulu Yang; Ann Qin; Justin Ly; Bianca Liederer; Kirsten Messick; Shuguang Ma; Mark Zak; Peter Dragovich; Brian Dean; Marcel Hop; Yuzhong Deng
Bioanalysis, ISSN: 17576180
Shuguang Ma; Swapan K. Chowdhury
Mass Spectrometry for Drug Discovery and Drug Development,
Shuguang Ma; Swapan K. Chowdhury
Bioanalysis, ISSN: 17576180
Shuguang Ma; Swapan K. Chowdhury
Education
- Purdue University, Ph.D in Analytical Chemistry – 1998
- University of Minnesota, MS in Chemistry – 1994
- Donghua University, BS in Environmental Engineering – 1991