Shuguang Ma
Senior Principal Scientist (Technology), Drug Metabolism & Pharmacokinetics
"I'm inspired in discovering and developing potential new drugs to treat serious diseases with unmet medical needs."
11
Years at Genentech
30
Publications at Genentech
I joined Genentech in 2011 as a Scientist after worked 10 years at other pharmaceutical and biotechnology companies. I currently lead the development biotransformation group in support of small molecule drug development. We focus on characterizing the absorption, distribution, metabolism, elimination properties of small molecule drug candidates using state-of-the-art and innovative technologies. I feel incredibly fortunate to have the opportunity working at such a great place with very talented and passionate scientists.
Featured Publication
Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST).
Drug Metab Lett. 2017 Nov 17;11(1):21-28.
Takahashi RH, Khojasteh C, Wright M, Hop CECA, Ma S.
My Focus
Our group focuses on providing key data on determining the rate and route of drug elimination, characterizing the structures of drug metabolites in circulation and excreta, and determining absorption and fraction of metabolism using radiolabeled drugs.
My areas of research interests include the development of novel LC/MS-based techniques for metabolite detection and investigation of biotransformation and bioactivation of xenobiotics.
Genentech Publications
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Binqing Wei; Kirk D. Robarge; Sharada Labadie; Jinhua Chen; Laura B. Corson; Antonio G. DiPasquale; Peter Dragovich; Eigenbrot; Marie Evangelista; Benjamin P. Fauber; Anna Hitz; Rebecca Hong; Kwong Wah Lai; Wenfeng Liu; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Ultsch; Zijin Xu; Ivana Yen; Dong Yu; Qin Yue; Aihe Zhou; Hans E. Purkey
Journal of Clinical Medicine, ISSN: 20770383
Victor Yip; M. Violet Lee; Ola M. Saad; Shuguang Ma; S. Cyrus Khojasteh; Shen
Xenobiotica, ISSN: 13665928 00498254
Qin Yue; S. Cyrus Khojasteh; Sungjoon Cho; Shuguang Ma; Teresa Mulder; John Chen; Jodie Pang; Xiao Ding; Alan Deese; Jackson D. Pellet; Nicholas Siebers; Lori Joas; Laurent Salphati; Joseph A. Ware
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hao Cai; Victor Yip; M. Violet Lee; Sylvia Wong; Ola M. Saad; Shuguang Ma; Nina Ljumanovic; S. Cyrus Khojasteh; Amrita Kamath; Shen
Chemical Research in Toxicology, ISSN: 15205010 0893228X
Chenghong Zhang; James J. Crawford; Matthew L. Landry; Huifen Chen; Jane R. Kenny; S. Cyrus Khojasteh; Wendy Lee; Shuguang Ma; Wendy B. Young
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jessica M. Grandner; Sudheer Bobba; Yanzhou Liu; Paul Beroza; Donglu Zhang; Shuguang Ma
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shuguang Ma; Julia Suchomel; Evelyn Yanez; Edward Yost; Xiaorong Liang; Rui Zhu; Hoa Le; Nicholas Siebers; Lori Joas; Roland Morley; Stephanie Royer-Joo; Andrea Pirzkall; Laurent Salphati; Joseph A. Ware; Kari M. Morrissey
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jason S Halladay; Michael Siu; Yuan Chen; Cornelis E. Hop; S. Cyrus Khojasteh; Shuguang Ma
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; S. Cyrus Khojasteh; Matthew Wright; Cornelis E. Hop; Shuguang Ma
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Xiaojing Wang; Nathaniel Segraves; Jing Wang; Jae H. Chang; S. Cyrus Khojasteh; Shuguang Ma
Xenobiotica, ISSN: 13665928 00498254
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo
ACS Medicinal Chemistry Letters, ISSN: 19485875
Hans E. Purkey; Kirk D. Robarge; Jinhua Chen; Zhongguo Chen; Laura B. Corson; Charles Z. Ding; Antonio G. DiPasquale; Peter Dragovich; Eigenbrot; Marie Evangelista; Benjamin P. Fauber; Zhenting Gao; Hongxiu Ge; Anna Hitz; Qunh Ho; Sharada Labadie; Kwong Wah Lai; Wenfeng Liu; Yajing Liu; Chiho Li; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Huihui Zhang; Aihe Zhou
Drug Metabolism Reviews, ISSN: 10979883 03602532
Jinping Gan; Shuguang Ma; Donglu Zhang
Nature Chemical Biology, ISSN: 15524469 15524450
Aaron Boudreau; Hans E. Purkey; Anna Hitz; Kirk D. Robarge; David Peterson; Sharada Labadie; Mandy Kwong; Rebecca Hong; Min Gao; Christopher J. Del Nagro; Raju V. Pusapati; Shuguang Ma; Laurent Salphati; Jodie Pang; Aihe Zhou; Tommy Lai; Yingjie Li; Zhongguo Chen; Binqing Wei; Ivana Yen; Steve Sideris; Mark L. McCleland; Ron Firestein; Laura B. Corson; Alexander N. Vanderbilt; Simon P. Williams; Anneleen Daemen; Marcia Belvin; Eigenbrot; Peter K Jackson; Shiva Malek; Georgia Hatzivassiliou; Deepak Sampath; Marie Evangelista; Thomas O'Brien
Drug Metabolism Letters, ISSN: 18723128
Hoa Le; Peter W. Fan; Susan C. Wong; Shuguang Ma; James Driscoll; Cornelis E. Hop; S. Cyrus Khojasteh
Bioanalysis, ISSN: 17576199 17576180
Shuguang Ma; Swapan K. Chowdhury
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Edna F. Choo; Shuguang Ma; Susan C. Wong; Jason S Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Cornelis E. Hop; S. Cyrus Khojasteh; Mark J. Dresser; Luna Musib
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Sarah J. Robinson; Qin Yue; Edna F. Choo; S. Cyrus Khojasteh
European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 21070180 03787966
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Joseph P. Lyssikatos; Kelly Regal; Kevin W. Hunt; Nicholas C. Kallan; Michael Siu; Cornelis E. Hop; Xingrong Liu; S. Cyrus Khojasteh
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Peter Dragovich; Benjamin P. Fauber; Jason Boggs; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Chiho Li; Yichin Liu; Yingchun Liu; Shuguang Ma; Shiva Malek; David Peterson; Keith Pitts; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
S. Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette M. Castanedo; Jacob Z. Chen; Joseph P. Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Cornelis E. Hop; Harvey Wong
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Alan Deese; Qin Yue; Heasook Kim-Kang; Yijun Yi; Michael Siu; Kevin W. Hunt; Nicholas C. Kallan; Cornelis E. Hop; Xingrong Liu; S. Cyrus Khojasteh
Toxicology Research, ISSN: 20454538 2045452X
Chenghong Zhang; Shuguang Ma; Erlie Marie Delarosa; Suzanne Tay; Jasleen K. Sodhi; Vivek Musinipally; Patricia Chang; Rama Pai; Jason S Halladay; Misner; Jane R. Kenny; Cornelis E. Hop; S. Cyrus Khojasteh
Bioanalysis, ISSN: 17576199 17576180
Shuguang Ma; Swapan K. Chowdhury
Bioanalysis, ISSN: 17576199 17576180
Xiaorong Liang; Lulu Yang; Ann R. Qin; Justin Ly; Bianca M. Liederer; Kirsten Messick; Shuguang Ma; Mark Zak; Peter Dragovich; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
Bioanalysis, ISSN: 17576180 17576199
Shuguang Ma; Swapan K. Chowdhury
Mass Spectrometry for Drug Discovery and Drug Development,
Shuguang Ma; Swapan K. Chowdhury
Bioanalysis, ISSN: 17576180 17576199
Shuguang Ma; Swapan K. Chowdhury
Education
- Purdue University, Ph.D in Analytical Chemistry – 1998
- University of Minnesota, MS in Chemistry – 1994
- Donghua University, BS in Environmental Engineering – 1991