Simon G. Wong - Senior Scientist, Drug Metabolism and Pharmacokinetics

Simon G. Wong

Senior Scientist, Drug Metabolism and Pharmacokinetics

"Having the resources and freedom to satisfy scientific curiosity becomes exponentially more rewarding when you see it translate to the discovery of new medicines."
3
Years at Genentech

I completed my doctoral thesis under the guidance of Dr Gerald S. Marks in the department of Pharmacology and Toxicology at Queen’s University in Kingston, Ontario Canada. As young, somewhat skeptical, and naive scientist, I felt my research on inhibitors of drug metabolizing enzymes was not particularly applicable, useful, or, most disconcerting at the time – marketable.

It was therefore very surprising for me to find myself recruited to join the department of Pharmacokinetics and Drug Metabolism at Sugen, with my first task to figure out why the exposure of a lead compound was decreasing after repeat dosing in dogs.

Not long after, I began to appreciate the link between alterations in drug metabolism and the overall exposure of a drug, and, more importantly, how understanding this process is a critical component to the development of new medicines.

I joined Genentech in 2015 and was immediately immersed in a community of passionate scientists that were clearly at the forefront of their respective fields. As a member of the Department of Drug Metabolism and Pharmacokinetics, I am responsible for understanding the potential for drug-drug interactions and advancing our ability to translate preclinical in vitro data to the clinic.

Featured Publication

Prediction of drug-drug interactions arising from mechanism-based inactivation: key input parameters and impact on risk assessment.

Curr Drug Metab. 2011 Nov;12(9):871-90./p>

Wong SG.