Scientists / Our Scientists

Steffen Durinck

Bioinformatics - Senior Scientist, Oncology Bioinformatics

Postdoc Mentor

"The high-quality research environment at Genentech and collaborative work opportunities of experimental and bioinformatics scientists is truly unrivalled in our field."

Years at Genentech

Publications at Genentech

I joined Genentech in early 2011 as the company was expanding its use of NGS sequencing in research. For many years, I was part of the NGS sequencing core lab bringing in and exploring the latest sequencing technologies.

Earlier in my career, I worked at Illumina which gave me a very early insight into the potential revolution that sequencing would bring to all aspects of biology research. Joining Genentech enabled me to apply these latest sequencing technologies in cancer research resulting in several high-profile publications of genomic characterizations of cancer types. A highlight for me from these studies was our finding of recurrent RSPO fusions in colorectal cancer which we published in Nature. As a bioinformatics scientist to find these genomic aberrations in silico and then have them validate in the lab and published is a truly thrilling experience.

Postdoctoral Mentor

Guiding the next-generation of bioinformatics scientists is a true passion of mine. At Genentech we get to mentor our postdoctoral scientists with ground breaking academic basic research projects and at the same time enable them to explore the industry aspects of our scientific endeavors.

Featured Publication

Recurrent R-spondin fusions in colon cancer.

Nature. 2012 Aug 30;488(7413):660-4. doi: 10.1038/nature11282.PMID: 22895193

Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ.

View Abstract

My current research focusses largely in three areas:

Bioinformatics applications in genome engineering
Single – cell sequencing applications
Functional genomics

Determinants of renal cell carcinoma invasion and metastatic competence

Nature Communications, ISSN: 20411723

Kangsan Kim; Qinbo Zhou; Alana Christie; Christina Stevens; Yuanqing Ma; Oreoluwa Onabolu; Suneetha Chintalapati; Tiffani McKenzie; Vanina Toffessi Tcheuyap; Layton Woolford; He Zhang; Nirmish Singla; Pravat Kumar Parida; Mauricio Marquez-Palencia; Ivan Pedrosa; Vitaly Margulis; Arthur Sagalowsky; Zhiqun Xie; Tao Wang; Durinck; Zora Modrusan; Somasekar Seshagiri; Payal Kapur; James Brugarolas; Srinivas Malladi

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Steffen Durinck

Bioinformatics - Senior Scientist, Oncology Bioinformatics

Featured Publication

Recurrent R-spondin fusions in colon cancer.