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Scientists / Our Scientists

Suzie Scales

Principal Scientist - Technology, Molecular Biology

Postdoc Mentor

"I lead the research program for one of the antibody-drug conjugates, which gratifyingly entered the clinic."

Years at Genentech

Publications

Awards & Honors

I studied membrane trafficking for my PhD (Kreis lab) and postdoc (Scheller lab) and was recruited to Genentech in 2001 to examine the endocytosis (internalization) of antibodies to cell surface cancer targets as part of the antibody-drug conjugate team. As well as helping to establish the rules for antibody trafficking and linker-drug selection, I lead the research program for one of the antibody-drug conjugates, which gratifyingly entered the clinic. We also explored the utility of antibody-siRNA conjugates and we are currently working on methods to visualize conjugate payload release within cells to test novel linkers.

Once here, I was recruited to the Hedgehog team to better understand the cell biology and trafficking of various components of this pathway, which led to our discovery that the transcription factors of the pathway (Gli1,2,3) accumulate at the tips of primary cilia (a sort of signaling antenna on the cell surface) upon stimulation by Hedgehog ligand. This naturally led to an interest in primary cilia, which have been implicated in several disparate diseases ("ciliopathies") and has become a pet project for postdoctoral students.

Postdoctoral Mentor

The best part about being a postdoc mentor is that it helps me to stay current in my area of interest outside of my pipeline projects and to learn new perspectives or techniques from my postdocs themselves, which are often very different than those of our regular team members. There are also no restraints on which direction the project takes, provided it leads to novel, publishable findings. It is also very rewarding to watch the postdocs develop into mature scientists during their stay here and to help them on their way to a stimulating career.

Featured Publication

Functional characterization of putative cilia genes by high-content analysis.

Mol Biol Cell. 2011 Apr;22(7):1104-19.

Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ.

View Abstract

One of the good things about working at Genentech is that because we work so collaboratively such that experts in a particular technique perform those experiments (with the added bonus of having high confidence in the results), we have time to spend exploring new areas. Thus, my lab recently completely shifted focus from cancer to kidney disease. We are interested in a protein mutated in chronic kidney disease and have generated over 100 monoclonal antibodies to understand its localization, biological function, and role in disease.

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Nidhi Gupta; Grace Wang; Xiaohui Wen; Paul Moran; Maciej Paluch; Phil Hass; Amy Heidersbach; Benjamin Haley; Daniel Kirchhofer; Randall Brezski; Andy Peterson; Suzie Scales

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Suzie Scales

Principal Scientist - Technology, Molecular Biology

Featured Publication

Functional characterization of putative cilia genes by high-content analysis.