Scientists / Our Scientists

Tangsheng Yi

Principal Scientist, Immunology Discovery

Postdoc Mentor

"We translate immunology discoveries to therapeutic molecule. The impact it makes on human biology and disease intervention makes it an extremely fulfilling career."

Years at Genentech

Publications at Genentech

Awards & Honors

I joined Genentech in 2014 as a scientist in Immunology Discovery after finishing my postdoctoral training at HHMI/UCSF, where I studied how immune cell trafficking and positioning shapes adaptive immune responses. I am drawn to Genentech because of its supportive and multidisciplinary environment that allows my curiosity in human physiology prosper, and fulfills my eager to translate immunology knowledge to medicine discovery.

Postdoctoral Mentor

Genentech offers the best postdoctoral training. Not only we conduct high quality basic research revealing cellular and molecular mechanism of human disease. What makes us unique is the opportunity to witness how scientific discoveries impact drug discovery and human medicine.

My current research aims to understand how defective mucosal barriers allows microbial translocations, dysbiosis, and subsequent inflammatory responses, which are often seen at serious inflammatory disorders of inflammatory bowel disease, asthma, and atopic dermatitis. The ultimate goal is to discover and develop new therapeutic agents to treat patients.

Mast cell tryptases in allergic inflammation and immediate hypersensitivity

Current Opinion in Immunology, ISSN: 18790372 09527915

Jonathan J. Lyons; Tangsheng Yi

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Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease

Cell Reports Medicine, ISSN: 26663791

Bingbing Dai; Jason A. Hackney; Ryan Ichikawa; Allen Nguyen; Justin Elstrott; Luz D. Orozco; Kai-Hui Sun; Zora Modrusan; Alvin Gogineni; Alexis Scherl; John Gubatan; Aida Habtezion; Monika Deswal; Ma Somsouk; William A. Faubion Jr.; Akiko Chai; Zaineb Sharafali; Azra Hassanali; Young S. Oh; Swati Tole; Jacqueline McBride; Mary E. Keir; Tangsheng Yi

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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

Nature Communications, ISSN: 20411723

Henry R. Maun; Rajesh Vij; Benjamin T. Walters; Ashley Morando; Janet Jackman; Ping Wu; Alberto Estevez; Xiaocheng Chen; Yvonne Franke; Michael T. Lipari; Dennis; Daniel Kirchhofer; Claudio Ciferri; Kelly M. Loyet; Tangsheng Yi; Eigenbrot; Lazarus; James T. Koerber

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Development of a specific immunoassay to selectively measure active tryptase in airway samples

Bioanalysis, ISSN: 17576199 17576180

Gizette Sperinde; Meire C. Bremer; Henry R. Maun; Amos Baruch; Lazarus; James T. Koerber; Rajesh Vij; Tangsheng Yi; Saloumeh Kadkhodayan Fischer; Tracy Staton

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The role of IL-22 in intestinal health and disease

Journal of Experimental Medicine, ISSN: 15409538 00221007

Mary E. Keir; Tangsheng Yi; Timothy T. Lu; Nico Ghilardi

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Cell, ISSN: 10974172 00928674

Henry R. Maun; Janet Jackman; David F. Choy; Kelly M. Loyet; Tracy Staton; Guiquan Jia; Amy Dressen; Jason A. Hackney; Meire C. Bremer; Benjamin T. Walters; Rajesh Vij; Xiaocheng Chen; Neil N. Trivedi; Ashley Morando; Michael T. Lipari; Yvonne Franke; Xiumin Wu; Juan Zhang; John Liu; Ping Wu; Diana Chang; Luz D. Orozco; Erin Christensen; Manda Wong; Corpuz; Julie Qi Hang; Jeff Lutman; Siddharth Sukumaran; Yan Wu; Savita Ubhayakar; Xiaorong Liang; Lawrence B. Schwartz; Magda Babina; Prescott G. Woodruff; John V. Fahy; Rahul Ahuja; George H. Caughey; Aija Kusi; Dennis; Eigenbrot; Daniel Kirchhofer; Cary D. Austin; Lawren C. Wu; James T. Koerber; Wyne P. Lee; Brian L. Yaspan; Kathila R. Alatsis; Joseph R. Arron; Lazarus; Tangsheng Yi

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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

Nature, ISSN: 14764687 00280836

Jianhua Li; Erick Lu; Tangsheng Yi; Jason G. Cyster

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Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses

Immunity, ISSN: 10974180 10747613

Tangsheng Yi; Jianhua Li; Hsin Chen; Jiaxi Wu; Jinping An; Ying Xu; Yongmei Hu; Clifford Lowell; Jason G. Cyster

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25-Hydroxycholesterols in innate and adaptive immunity

Nature Reviews Immunology, ISSN: 14741741 14741733

Jason G. Cyster; Eric V. Dang; Andrea Reboldi; Tangsheng Yi

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University of California, San Francisco/Howard Hughes Medical Institute, Postdoctoral Fellow – 2014
City of Hope National Medical Center, Ph.D. in Immunology – 2009
Nanjing University, China, B.S. in Molecular Biology and Biochemistry – 2005

Cancer Research Institute Irvington Postdoctoral Fellowship Award – 2011 - 2014

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Tangsheng Yi

Principal Scientist, Immunology Discovery