"Genentech's scientists and team spirit inspire me to go beyond my boundaries, this and the wish to apply my knowledge to ultimately help patients makes me come to work with a feeling of pride and purpose."
I felt attracted to Genentech because of its excellent scientific reputation. My experience had been about half and half academic and industrial, I gained expertise on protein NMR methods by determining multiple protein structures in solution in academia. I then moved to developing small molecule NMR methods in pharmaceutical drug discovery. At Genentech I strive to apply the two together to get the best of both approaches. I have not regretted my decision to come here for a single day.
Proc Natl Acad Sci USA 109, 5299–5304 (2012).
The NMR group strives to play a driving role in the process of making novel drugs. Our perception of what make proteins work often does not consider changes in structure and dynamics that take place upon interaction with other molecules such as drugs or other proteins and during catalysis.
The work we do in the NMR lab opens the window for looking at dynamic changes in target proteins upon binding interaction with drugs or functionally important protein interaction partners in the solution state. This adds the information on how compounds do their work such as:
Given a set of possible candidates for development into a drug, NMR can observe on an atomic level how these molecules interact with the target. We can thus add important information to the selection process so that in the end we get the appropriate candidates for clinical testing by the most clear and direct path.