Tom Patapoff - Technical Development Staff Scientist, Early Stage Pharmaceutical Development

Tom Patapoff

Technical Development Staff Scientist, Early Stage Pharmaceutical Development

Postdoc Mentor
Staff Scientist
"Times are changing… We are changing them."
26
Years at Genentech
55
Publications

I graduated with a Ph.D. in Chemistry from the University of Oregon. I worked two years at a large defense firm as a “rocket scientist”, working on fiber optic gyroscopes and other things I still can’t talk about. I then worked two years at a small start-up formulating insulin for intra-nasal delivery. Then I came to Genentech in 1991 as a scientist in Pharmaceutical Research and Development (Pharm R&D). This is the group that figures out the best pH and excipients that make our proteins (our drugs) suitable enough to withstand manufacturing, storage, shipping, compounding, and whatever other conditions to which it may be exposed before it is administered to the patient. This requires a significant understanding of biochemistry and biophysics.

I became Director of Pharm R&D in 2001 and led the group until I stepped down from directorship in 2006 to get back in the lab. I never looked back.

Postdoctoral Mentor

I run the postdoc program in PTDU. Being the Post Doc coordinator is great! I get to learn from all these really smart and focused postdocs. They have really good ideas and while at Genentech, lots of resources… like a kid in a candy store… In the PTD postdoc program, postdocs interact and learn from other postdoc in other departments spanning Cell Culture, Purification, Analytical Chemistry, Drug Delivery, Formulation, and Biophysics. It’s hard to keep up with it all!

Featured Publication

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations.

MAbs. 2013 Mar-Apr;5(2):306-22. Epub 2013 Feb 8.

Kortkhonjia E, Brandman R, Zhou JZ, Voelz VA, Chorny I, Kabakoff B, Patapoff TW, Dill KA, Swartz TE.