Valerie Quarmby
Senior Fellow, BioAnalytical Sciences
Fellow
"Genentech is a tremendously exciting place to work. Biotherapeutic development is constantly evolving, so I am always on a learning curve, building on experience and continuing to gather new information about the field. I really enjoy working in a cross-functional environment with terrific colleagues who are subject matter experts in a wide range of scientific disciplines."
29
Years at Genentech
46
Publications at Genentech
7
Awards & Honors
I joined Genentech as a Scientist in 1994 after a PhD and postdoctoral training in molecular and cellular endocrinology and in the clinical diagnostics industry. I initially generated bioanalytical methods and data to support molecules in our endocrine portfolio. Since then, I have had the opportunity to develop bioanalytical methods and/or strategies to enable IND, BLA, NDA and related filings for most of the approved biotherapeutics in our portfolio. I also learned a tremendous amount about drug development during my time as Pharmacology Team Leader for a particular medicine. I think that the most rewarding aspect of my job is developing medicines that make it into the clinic for the treatment and management of life-threatening diseases.
Featured Publication
Generation and Characterization of a Unique Reagent that Recognizes a Panel of Recombinant Human Monoclonal Antibody Therapeutics in the Presence of Endogenous Human IgG.
MAbs 2013, 5:540-554
Wang X, Quarmby V, Ng C, Chuntharapai A, Shek T, Eigenbrot C, Kelley R F, Shia S, McCutcheon K, Lowe J, Leddy C, Coachman K, Cain G, Chu F, Hotzel I, Maia M, Wakshull E, and Yang J.
My Focus
I currently run the Core Biophysical Characterization & Reagent Facility in BioAnalytical Sciences (BAS), and I also lead the BAS review group that endorses bioanalytical strategies for all protein therapeutics in the gRED drug development pipeline.
Development Sciences (DevSci), does translational drug development work for gRED. Within DevSci, BAS generates bioanalytical methods and data to characterize pharmacokinetics and pharmacodynamics of our molecules along with any immune responses. DevSci is a highly collaborative work environment, and I interact with colleagues who are experts in a wide range of drug development disciplines In addition I consult, and actively participate with teams across the Roche/Genentech organization and interact with Health Authorities on strategic and technical aspects of bioanalysis.
Externally, I am a member of the United States Pharmacopeia Immunogenicity Testing Expert Panel, and I also chaired the American Association of Pharmaceutical Scientists Therapeutic Protein Immunogenicity Focus Group from 2012-2014.
Genentech Publications
Cancer Reports, ISSN: 25738348
Cristina Julian; Robson J. M. Machado; Sandhya Girish; Pascal Chanu; Dominik Heinzmann; Chris Harbron; Anda Gershon; Shannon M. Pfeiffer; Wei Zou; Quarmby; Qing Zhang; Ya-Chi Chen
Clinical and Translational Science, ISSN: 17528062 17528054
Christian Hammer; Jane Ruppel; Lynn Kamen; Julie Hunkapiller; Ira Mellman; Quarmby
Clinical and Translational Science, ISSN: 17528062 17528054
Christian Hammer; Jane Ruppel; Lynn Kamen; Julie Hunkapiller; Ira Mellman; Quarmby
Clinical and Translational Science, ISSN: 17528054
Christian Hammer; Jane Ruppel; Lynn Kamen; Julie Hunkapiller; Ira Mellman; Quarmby
Cancer Reports, ISSN: 25738348
Cristina Julian; Robson J. M. Machado; Sandhya Girish; Pascal Chanu; Dominik Heinzmann; Chris Harbron; Anda Gershon; Shannon M. Pfeiffer; Wei Zou; Quarmby; Qing Zhang; Ya-Chi Chen
Clinical and Translational Science, ISSN: 17528062 17528054
Solange Peters; Peter R. Galle; Coen A. Bernaards; Ballinger; Rene Bruno; Quarmby; Jane Ruppel; Alexandr Vilimovskij; Benjamin Wu; Nitzan Sternheim; Martin Reck
Clinical and Translational Science, ISSN: 17528062 17528054
Benjamin Wu; Nitzan Sternheim; Priya Agarwal; Julia Suchomel; Shweta Vadhavkar; Rene Bruno; Ballinger; Coen A. Bernaards; Phyllis Chan; Jane Ruppel; Jin Jin; Sandhya Girish; Amita Joshi; Quarmby
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Mathilde Marchand; Rong Zhang; Phyllis Chan; Quarmby; Ballinger; Nitzan Sternheim; Benjamin Wu; Jin Yan Jin; Rene Bruno
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Vanderlaan; Aristides Maniatis; Robert Olney; Abdelkader Rahmaoui; Linda Yau; Quarmby; Craig Azzolino; Cynthia Woods; Dalia Moawad
Antibodies, ISSN: 20734468
Xiangdan Wang; Minh Michael Phan; Ji Li; Herman S. Gill; Simon P. Williams; Nidhi Gupta; Quarmby; Yang
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Andrzej M. Kierzek; Timothy P. Hickling; Isabel Figueroa; Kalvass; Marjoleen JMA Nijsen; Krithika Mohan; Geertruida M. Veldman; Akihiro Yamada; Hiroyuki Sayama; Sachiko Yokoo; Abhishek Gulati; Renu S. Dhanikula; Jochem Gokemeijer; Tarek A. Leil; Craig J. Thalhauser; Mario Giorgi; Maciej J. Swat; Vijayalakshmi Chelliah; Ben G. Small; Neil Benson; Michael Walker; Kapil Gadkar; Quarmby; Rong Deng; Andrea Ferrante; Gemma L. Dickinson; Jan-Stefan Van Der Walt; Lian Zhou; Xiaoying Chen; Hannah M. Jones; Jatin Narula; Sophie Tourdot; Thierry Lavé; Ribba; Van Der Graaf
Expert Review of Proteomics, ISSN: 17448387 14789450
Quarmby; Qui Phung; Jennie R. Lill
AAPS Journal, ISSN: 15507416
Eric Wakshull; Quarmby; Hanns-Christian Mahler; Hongwen Rivers; Dhananjay Jere; Meg Ramos; Piotr Szczesny; Karoline Bechtold-Peters; Sharmila Masli; Swati Gupta
mAbs, ISSN: 19420870 19420862
Xiangdan Wang; McKay; Liliana T. Yee; George Dutina; Hass; Ihsan Nijem; David E. Allison; Kyra J. Cowan; Kevin Lin; Quarmby; Yang
Biologicals, ISSN: 10958320 10451056
Nadja Alt; Taylor Zhang; Paul Motchnik; Ron Taticek; Quarmby; Tilman Schlothauer; Hermann Beck; Thomas Emrich; Reed J. Harris
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Christina de Zafra; Quarmby; Kathleen Francissen; Vanderlaan; Judith Zhu-Shimoni
Bioanalysis, ISSN: 17576199 17576180
Zhihua Julia Qiu; Yong Ying; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Suzanne Brignoli; Robert Hendricks; Patricia Siguenza; Quarmby; Saloumeh Kadkhodayan Fischer; An Song
Nature Biotechnology, ISSN: 15461696 10870156
Gopi Shankar; Arkin; Viswanath Devanarayan; Kromminga; Quarmby; Richards; Subramanyam; Steven J. Swanson
BioProcess International, ISSN: 15426319
Vanderlaan; Wendy N. Sandoval; Peter S. Liu; Julie C. Nishihara; George Tsui; Margaret Lin; Feny Gunawan; Sara Parker; Robert Ming Wong; Justin Low; Xiangdan Wang; Yang; Karthik Veeravalli; McKay; X. Christopher Yu; O'Connell; Benjamin Tran; Rajesh Vij; Chris Fong; Kathleen Francissen; Judith Zhu-Shimoni; Quarmby; Denise C. Krawitz
AAPS Journal, ISSN: 15507416
Gopi Shankar; Arkin; Cocea; Viswanath Devanarayan; Susan Kirshner; Kromminga; Quarmby; Richards; Schneider; Subramanyam; Steven J. Swanson; Verthelyi; Yim
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Chae Reed; Carl Ng; Zhijie Jey Cheng; Fabio Malavasi; Yang; Quarmby; An Song
AAPS Journal, ISSN: 15507416
Ashwin Parenky; Heather Myler; Lakshmi Amaravadi; Karoline Bechtold-Peters; Amy Rosenberg; Susan Kirshner; Quarmby
mAbs, ISSN: 19420862 19420870
Xiangdan Wang; Quarmby; Carl Ng; Anan Chuntharapai; Theresa Shek; Eigenbrot; Robert F. Kelley; Steven Shia; Krista McCutcheon; John Lowe; Cecilia Leddy; Kyle Coachman; Cain; Felix Chu; Isidro Hötzel; Mauricio Maia; Eric Wakshull; Yang
mAbs, ISSN: 19420862 19420870
Shan Chung; Quarmby; Xiaoying Gao; Yong Ying; Yuwen L. Lin; Chae Reed; Chris Fong; Wendy Lau; Zhihua Julia Qiu; Amy Shen; Vanderlaan; An Song
Arthritis and Rheumatism, ISSN: 00043591 15290131
Alyssa M. Morimoto; Donna Thibault Flesher; Yang; Kristen Wolslegel; Xiangdan Wang; Ann Brady; Abbas Alexander; Quarmby; Eric Wakshull; Bruce C. Richardson; Michael J. Townsend; Timothy W. Behrens
Bioanalysis, ISSN: 17576180 17576199
Yang; Quarmby
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Kun Peng; Ketevan A. Siradze; Quarmby; Saloumeh Kadkhodayan Fischer
Journal of Immunological Methods, ISSN: 00221759
Zhihua Julia Qiu; Yong Ying; Michael Fox; Kun Peng; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Jeremy Good; John Lowe; Amena Rahman; Yang; Jenny Jiang; Quarmby; An Song
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
John Lowe; Mauricio Maia; Eric Wakshull; Patricia Siguenza; Patrick Liu; Saleem Lakhani; Jeriza Rusit; Rebecca Elliott; Quarmby
Journal of Immunological Methods, ISSN: 00221759
Krista McCutcheon; Quarmby; An Song
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Gopi Shankar; Viswanath Devanarayan; Lakshmi Amaravadi; Yu Chen Barrett; Ronald Bowsher; Deborah Finco-Kent; Michele Fiscella; Boris Gorovits; Susan Kirschner; Michael Moxness; Thomas Parish; Quarmby; Holly W. Smith; Wendell Smith; Linda A. Zuckerman; Koren
Journal of Immunological Methods, ISSN: 00221759
Yang; Carl Ng; Henry B. Lowman; Chestnut; Cheryl A. Schofield; Bryan Sandlund; James A. Ernst; Bennett; Quarmby
Journal of Immunological Methods, ISSN: 00221759
Koren; Holly W. Smith; Elizabeth Shores; Gopi Shankar; Deborah Finco-Kent; Bonita Rup; Yu Chen Barrett; Viswanath Devanarayan; Boris Gorovits; Shalini Gupta; Thomas Parish; Quarmby; Michael Moxness; Steven J. Swanson; Gary Taniguchi; Linda A. Zuckerman; Christopher C. Stebbins; Mire-Sluis
Experimental Eye Research, ISSN: 00144835
John Lowe; James Araujo; Yang; Mike Reich; Amy Oldendorp; Vanessa Shiu; Quarmby; Henry B. Lowman; Samantha Lien; Jacques Gaudreault; Mauricio Maia
Pharmaceutical Research, ISSN: 07248741 1573904X
JoMarie Smolec; Binodh DeSilva; Wendell Smith; Russell Weiner; Marian Kelly; Ben Lee; Masood Khan; Richard Tacey; Howard Hill; Abbie Celniker; Vinod Shah; Ronald Bowsher; Mire-Sluis; John W. A. Findlay; Mary Saltarelli; Quarmby; David Lansky; Robert Dillard; Martin Ullmann; Steve Keller; H. Thomas Karnes
Pharmaceutical Research, ISSN: 07248741
Jean W. Lee; Russell Weiner; Jeff M. Sailstad; Ronald Bowsher; Dean W. Knuth; Peter J. O'Brien; Jean L. Fourcroy; Rakesh Dixit; Lini Pandite; Robert G. Pietrusko; Holly D. Soares; Quarmby; Ole L. Vesterqvist; David M. Potter; James L. Witliff; Herbert A. Fritche; Timothy O'Leary; Lorah Perlee; Sunil Kadam; John A. Wagner
Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics,
Victor Ling; Bao-Jen Shyong; Bryan Sandlund; Quarmby; Gary Tanuguchi; Jonathan McNally; Van Chen
Journal of Immunological Methods, ISSN: 00221759
Chestnut; Quarmby
Journal of Endocrinology, ISSN: 00220795
Baxter; Svejkar; Khosravi; Bennett; Hardman; Senese; Mistry; Walton; Quarmby
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Michael D Sadick; Anthony Intintoli; Quarmby; April McCoy; Eleanor Canova-Davis; Victor Ling
Developments in biological standardization, ISSN: 03015149
Quarmby; Quan
American Journal of Physiology - Endocrinology and Metabolism, ISSN: 01931849
Nelly Mauras; Quarmby; Duane C. Bloedow
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Quarmby; Quan; Victor Ling; Peter G. Compton; Eleanor Canova-Davis
Journal of Controlled Release, ISSN: 01683659
Cleland; Duenas; Daugherty; Marian; Yang; Wilson; Abbie Celniker; Shahzamani; Quarmby; Chu; Mukku; Mac; Roussakis; Nancy Gillette; Brooks Boyd; Yeung; Brooks; Maa; Chung C. Hsu; Andrew J.S. Jones
Endocrinology and Metabolism, Supplement, ISSN: 1074939X
Nelly Mauras; Paul M. Martha Jr.; Quarmby; Haymond
American Journal of Physiology - Endocrinology and Metabolism, ISSN: 01931849
Nelly Mauras; Paul M. Martha Jr.; Quarmby; Haymond
Education
- Imperial Cancer Research Fund & University of London, Ph.D. –
- Royal Holloway College, University of London, B.Sc. in Zoology with Botany –
Awards & Honors
- AAPS Fellow Status – 2014
- Elected Member of Endocrine Society –
- Royal Holloway College, University of London, 1st Year Undergraduate Award –
- Royal Holloway College, University of London, 3rd Year Undergraduate Award –
- Royal Holloway College, University of London, 2nd Year Undergraduate Award –
- Imperial Cancer Research Fund Research Bursary –
- NIH Fogarty International Postdoctoral Fellowship –