Wendy Sandoval - Director & Distinguished Scientist, Microchemistry, Proteomics & lipidomics

Wendy Sandoval

Director & Distinguished Scientist, Microchemistry, Proteomics & lipidomics

Postdoc Mentor
"get ‘er done!"
Years at Genentech
Publications at Genentech

I grew up at Genentech. Although my department name hasn’t changed in years, I am inspired every day by new analytical puzzles that need solving. Each day there is a challenge delivered, an intriguing biological question, a need for technological advancement, or the reward of providing data that contributes to understanding an MOA or binding preference. Although my group does proteomics and lipidomics, for the past ten years I have been largely focused on bringing native mass spectrometry into an industrial setting.

Postdoctoral Mentor

I am excited to mentor younger scientists. I feel like I have a lot to offer from my experiences both scientifically and career-wise, and have super exciting scientific areas to co-explore! Currently my main technological foci relate to improving methods for investigating membrane proteins and their ligands by native MS and developing top down methods for de novo sequencing of antibodies for biological matrices.

Featured Publication

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

Anal Chem. 2019 Jan 2;91(1):903-911. doi: 10.1021/acs.analchem.8b03829. Epub 2018 Dec 12.

Chengfeng Ren, Aaron O Bailey 1, Erica VanderPorten, Angela Oh, Wilson Phung, Melinda M Mulvihill, Seth F Harris, Yichin Liu, Guanghui Han, Wendy Sandoval

Denaturing and Native Mass Spectrometric Analytics for Biotherapeutic Drug Discovery Research: Historical, Current, and Future Personal Perspectives

J Am Soc Mass Spectrom. 2021 Aug 4;32(8):1861-1885. doi: 10.1021/jasms.1c00036. Epub 2021 Apr 22.

CIain D G Campuzano, Wendy Sandoval

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

MAbs. 2018 Nov-Dec;10(8):1214-1225. doi: 10.1080/19420862.2018.1521131. Epub 2018 Oct 19.

Aaron O Bailey, Guanghui Han, Wilson Phung, Paul Gazis, Jennifer Sutton, Jonathan L Josephs, Wendy Sandoval

Rapid, Semi-Automated Protein Terminal Characterization by Mass Spectrometry

Nat Biotechnol. 2016 Aug 9;34(8):811-3. doi: 10.1038/nbt.3621.

Corey E Bakalarski, Yutian Gan, Ingrid Wertz, Jennie R Lill, Wendy Sandoval