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Scientists / Our Scientists

"We all know friends and family members that have suffered with serious illness. It can be devastating. My goal, alongside my colleagues, is to discover agents that will treat these patients. The motto "patients are waiting" really hits home with everyone."

Years at Genentech

Publications

Awards & Honors

I was drawn to join Genentech, in 2006, because of its reputation for doing excellent science and employing strong teamwork. At Genentech, any team member with a compelling idea gets a chance to be heard and access to the resources to move their idea forward. The organization is also very nimble and open-minded to incorporate processes to accelerate discovery and development.

Today, I am Senior Vice President of Small Molecule Drug Discovery. In this role I oversee a highly talented and experienced group of multidisciplinary scientists working to generate the next generation of new medicines for patients in need.

What excites me the most is that, at Genentech, we have the brightest people, newest tools, and lots of know-how to continue to make huge strides in solving complex biological and medical issues. It is a huge opportunity and responsibility to shape the future treatments for patients in need.

Featured Publication

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Journal of Medicinal Chemistry, ISSN: 00222623

James J. Crawford; Adam Johnson; Misner; Lisa Belmont; Georgette Castanedo; Regina Choy; Melis Coraggio; Liming Dong; Charles Eigenbrot; Rebecca Erickson; Nico Ghilardi; Jonathan Hau; Arna Katewa; Pawan Bir Kohli; Wendy Lee; Joe Lubach; Brent McKenzie; Dan Ortwine; Leah Schutt; Suzanne Brown; Binqing Wei; Karin Reif; Lichuan Liu; Harvey Wong; Wendy Young

View Abstract

Ensuring that we have a culture that supports innovation and provides access to the most cutting-edge approaches and tools is key. Just as important is that we continue to recruit and retain the brightest scientists on the planet.

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: A new treatment strategy for ibrutinib-resistant CLL

Blood, ISSN: 15280020 00064971

Sean D. Reiff; Elizabeth M. Muhowski; Daphne Guinn; Amy Lehman; Catherine A. Fabian; Carolyn Cheney; Rose Mantel; Lisa Smith; Amy J. Johnson; Wendy Young; Adam Johnson; Lichuan Liu; John C. Byrd; Jennifer A. Woyach

View on Scopus

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Journal of Medicinal Chemistry, ISSN: 00222623

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

ACS Medicinal Chemistry Letters, ISSN: 19485875

Gina Wang; Jim Barbosa; Peter Blomgren; Meire Bremer; Jacob Chen; James Crawford; Wei Deng; Liming Dong; Charles Eigenbrot; Steven L. Gallion; Jonathon Hau; Huiyong Hu; Adam Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Dipaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy Young

View on Scopus

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis

JCI insight, ISSN: 23793708

Arna Katewa; Yugang Wang; Jason Hackney; Tao Huang; Eric Suto; Nandhini Ramamoorthi; Cary Austin; Meire Bremer; Jacob Chen; James Crawford; Kevin S. Currie; Peter Blomgren; Jason DeVoss; Julie Dipaolo; Jonathan Hau; Adam Johnson; Justin Lesch; Laura DeForge; Zhonghua Lin; Marya Liimatta; Joe Lubach; Sami McVay; Zora Modrusan; Allen Nguyen; Chungkee Poon; Jianyong Wang; Lichuan Liu; Wyne Lee; Harvey Wong; Wendy Young; Michael Townsend; Karin Reif

View on Scopus

Bruton's tyrosine kinase small molecule inhibitors induce a distinct pancreatic toxicity in rats

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103

Rebecca Erickson; Leah Schutt; Jacqueline Tarrant; Michelle McDowell; Lichuan Liu; Adam Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Jed Ross; Rick Carano; Karin Staflin; Fiona Zhong; James Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy Young; Donna Dambach; Misner

View on Scopus

Battling Btk Mutants with Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

ACS Chemical Biology, ISSN: 15548937

Adam Johnson; Pawan Bir Kohli; Arna Katewa; Emily Gogol; Lisa Belmont; Regina Choy; Elicia Penuel; Luciana Burton; Charles Eigenbrot; Christine Yu; Dan Ortwine; Krista Bowman; Yvonne Franke; Christine Tam; Alberto Estevez; Kyle Mortara; Jiansheng Wu; Hong Li; May Lin; Philippe Bergeron; James Crawford; Wendy Young

View on Scopus

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Charles Eigenbrot; Steven L. Gallion; Adam Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie

View on Scopus

Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Steven L. Gallion; Sarah Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Greg Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie

View on Scopus

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug Metabolism and Disposition, ISSN: 00909556

Lichuan Liu; Jason Halladay; Young Shin; Susan Wong; Melis Coraggio; Hank La; Matt Baumgardner; Hoa Le; Sashi Gopaul; Jason Boggs; Peter Kuebler; John Davis; Charlene Liao; Joe Lubach; Alan Deese; Greg Sowell; Kevin S. Currie; Wendy Young; Cyrus Khojasteh; Marcel Hop; Harvey Wong

View on Scopus

Pyrazolopyridine inhibitors of B-RafV600E. Part 1: The development of selective, orally bioavailable, and efficacious inhibitors

ACS Medicinal Chemistry Letters, ISSN: 19485875

Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner-Toste; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kimberly Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Kobe Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy Young; Jonas Grina

View on Scopus

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis

Nature Chemical Biology, ISSN: 15524450

Julie Di Paolo; Tao Huang; Mercedesz Balazs; Jim Barbosa; Kai Barck; Brandon Bravo; Rick Carano; James Darrow; Douglas R. Davies; Laura DeForge; Lauri Diehl; Ronald Ferrando; Steven L. Gallion; Tony Giannetti; Peter Gribling; Vincent Hurez; Sarah Hymowitz; Randall Jones; Jeffrey E. Kropf; Wyne Lee; Patricia M. MacIejewski; Scott A. Mitchell; Hong Rong; Bart L. Staker; J. Andrew Whitney; Sherry Yeh; Wendy Young; Christine Yu; Juan Zhang; Karin Reif; Kevin S. Currie

View on Scopus

Sloan Kettering Cancer Center, American Cancer Society, Postdoctoral Fellow – 1995
Princeton University, Ph.D. Chemistry – 1993
Wake Forest University, B.A./M.S. Chemistry, cum laude – 1988

Bachman Lectureship Award, University of Michigan – 2020
ACS National Earle B. Barnes Award in Research and Chemical Management – 2020
Schneller Legacy Lecture Award, University South Florida – 2019
Featured in “Twenty Extraordinary Women in BioPharma”, Endpoints – 2019
American Chemical Society Fellow – 2018
Genentech Inventor’s Award – 2018
Distinguished Lectureship Award, University of Kentucky – 2018
Elected Chair of National ACS MEDI – 2017
Elected Program Chair of National ACS MEDI – 2015-2016
Awarded “Most Influential Women of 2015” by San Francisco Business Times – 2015
American Cancer Society Postdoctoral Fellowship – 1993-1995
H. W. Dodds - Princeton University Honorific Fellowship, Top Thesis Award – 1993
Josephine de Karman Fellowship – 1992
ACS Graduate Fellowship sponsored by Lilly Research Laboratories – 1991-1992
Department of Education Graduate Fellowship – 1990
BA/MS Chemistry Scholarship, Wake Forest University – 1988

Portraits in Science

The Molecule Maker

The thrill of building medicines from scratch fuels Wendy Young’s chemistry career.

Drugging the Undruggable

Explore how we’re addressing long-standing challenges in drug discovery.

What’s in a Pill?

Featuring Wendy Young, Vice President of Discovery Chemistry at Genentech.

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Genentech takes the health and safety of our patients, customers, employees and local communities very seriously, and we are actively responding to the global COVID-19 pandemic. For more, please visit our COVID-19 response page.

Wendy Young

Senior Vice President, Small Molecule Drug Discovery

Featured Publication

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Portraits in Science

The Molecule Maker

Drugging the Undruggable

What’s in a Pill?

Attention: This page may not render properly. The browser you are using, Internet Explorer 10, is no longer supported.

Genentech takes the health and safety of our patients, customers, employees and local communities very seriously, and we are actively responding to the global COVID-19 pandemic. For more, please visit our COVID-19 response page.

A link to this page has been copied to your clipboard.

Wendy Young

Senior Vice President, Small Molecule Drug Discovery

Featured Publication

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

Portraits in Science

The Molecule Maker

Drugging the Undruggable

What’s in a Pill?