Jennie Lill

Associate Director, Protein Chemistry

POSTDOC MENTOR

"My inspiration comes from the enthusiasm and dedication of my team and collaborators. I am extremely proud to be part of this rewarding endeavor and excited to see our current early stage drug discovery research & technology development projects come to fruition."

• 12
  years at Genentech
• 19
  publications (2010-12)
• 2
  awards & honors

I decided to pursue a career at Genentech as it presented the opportunity to join a world-leading research environment.

As a member of the Protein Chemistry department, I have become involved in many projects encompassing a variety of disciplines and cutting-edge drug discovery research topics. In addition to these collaborations, I have also had the opportunity to initiate novel biochemical and mass spectrometric technology development projects.

• My Focus

  My lab is focused on developing methods for the high throughput and sensitive characterization of proteins, and the isolation and characterization of post translational modifications to aid in the elucidation of novel intracellular signaling mechanisms and drug discovery efforts.

  Our current technological development projects include high throughput antibody de novo sequencing, SUMOylation site mapping protocols and the development of bioinformatic tools too allow us to stream line our data analysis. We are also involved with developing methods using the PTMscan technology licensed from Cell Signaling Technologies to unravel low level signaling pathways to aid in understand cellular signaling events.

• Publications

  • Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases

    Science Signaling, 2013, ISSN: 1945-0877

    Zhuang, Guanglei; Yu, Kebing; Jiang, Zhaoshi; Chung, Alicia; Yao, Jenny; Ha, Connie; Toy, Karen; Soriano, Robert; Haley, Benjamin; Blackwood, Elizabeth; Sampath, Deepak; Bais, Carlos; Lill, Jennie R; Ferrara, Napoleone

     View on PubMed

  • A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway

    International Journal of Proteomics, 2013, ISSN: 2090-2166

    Anania, Veronica; Bustos, Daisy; Lill, Jennie; Kirkpatrick, Donald; Coscoy, Laurent

     View on PubMed

  • Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

    Science, 2013, ISSN: 0036-8075

    Huang, Xiaodong; McGann, James C; Liu, Bob Y; Hannoush, Rami N; Lill, Jennie R; Pham, Victoria; Newton, Kim; Kakunda, Michael; Liu, Jinfeng; Yu, Christine; Hymowitz, Sarah G; Hongo, Jo-Anne; Wynshaw-Boris, Anthony; Polakis, Paul; Harland, Richard M; Dixit, Vishva M

     View on PubMed

  • The Chromosome-Centric Human Proteome Project: A Call to Action

    Journal of Proteome Research, 2012, ISSN: 1535-3893

    Huehmer, Andreas F. R.; Paulus, Aran; Martin, LeRoy B.; Millis, Kevin; Agreste, Tasha; Saba, Julian; Lill, Jennie R.; Fischer, Steven M.; Dracup, William; Laver, Paddy

     View on PubMed

  • TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

    Molecular Cell, 2012, ISSN:

    Gonzalvez, Francois; Lawrence, David; Yang, Becky; Yee, Sharon; Pitti, Robert; Marsters, Scot; Pham, Victoria C; Stephan, Jean-Philippe; Lill, Jennie; Ashkenazi, Avi

     View on PubMed

  • Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

    Science, 2012, ISSN: 0036-8075

    Dey, Anwesha; Seshasayee, Dhaya; Noubade, Rajkumar; French, Dorothy M; Liu, Jinfeng; Chaurushiya, Mira S; Kirkpatrick, Donald S; Pham, Victoria C; Lill, Jennie R; Bakalarski, Corey E; Wu, Jiansheng; Phu, Lilian; Katavolos, Paula; Lafave, Lindsay M; Abdel-Wahab, Omar; Modrusan, Zora; Seshagiri, Somasekar; Dong, Ken; Lin, Zhonghua; Balazs, Mercedesz; Suriben, Rowena; Newton, Kim; Hymowitz, Sarah; Garcia-Manero, Guillermo; Martin, Flavius; Levine, Ross L; Dixit, Vishva M

     View on PubMed

  • Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins

    Methods in Molecular Biology, 2012, ISSN: 1064-3745

    Lill, Jennie R; Nesatyy, Victor J;

     View on PubMed

  • Complementary Proteomic Tools for the Dissection of Apoptotic Proteolysis Events

    Journal of Proteome Research, 2012, ISSN: 1535-3893

    Pham, Victoria C.; Pitti, Robert; Anania, Veronica G.; Bakalarski, Corey E.; Bustos, Daisy; Jhunjhunwala, Suchit; Phung, Qui T.; Yu, Kebing; Forrest, William F.; Kirkpatrick, Donald S.; Ashkenazi, Avi; Lill, Jennie R.

     View on PubMed

  • Complementary Proteomic Tools for the Dissection of Apoptotic Proteolysis Events.

    Journal of Proteome Research, 2012, ISSN:

    Pham VC; Pitti R; Anania VG; Bakalarski CE; Bustos D; Jhunjhunwala S; Phung QT; Yu K; Forrest WF; Kirkpatrick DS; Ashkenazi A; Lill JR.

     View on PubMed

  • Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

    PLoS ONE, {PLoS-ONE}, 2011, vol. 6, no. 7, article number: e22595, 35 refs, eISSN: 1932-6203. Publisher: Public Library of Science, 185 Berry Street, Suite 1300, San Francisco, CA 94107, USA.

    Callow, Marinella G; Tran, Hoanh; Phu, Lilian; Lau, Ted; Lee, James; Sandoval, Wendy N; Liu, Peter S; Bheddah, Sheila; Tao, Janet; Lill, Jennie R; Hongo, Jo Anne; Davis, David; Kirkpatrick, Donald S; Polakis, Paul; Costa, Mike

     View on PubMed

  • Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry.

    Molecular Cell, 2011, ISSN: 1097-4164

    Huang, X.; Summers, M.K.; Pham, V.; Lill, J.R.; Liu, J.; Lee, G.; Kirkpatrick, D.S.; Jackson, P.K.; Fang, G.; Dixit, V.M.

  • Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody.

    Proteomics, 2011, ISSN: 1615-9853

    Castellana, N.; McCutcheon, K.; Pham, V.; Harden, K.; Nguyen, A.; Young, J.; Adams, C.; Schroeder, K.; Arnott, D.; Bafna, V.; Grogan, J.; Lill, J.

  • Template Proteogenomics: Sequencing Whole Proteins Using an Imperfect Database.

    Molecular and Cellular Proteomics, 2010, ISSN: 1535-9476

    Castellana, N.; Pham, V.; Arnott, D.; Lill, J.; Bafna, V.

  • Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.

    Nature, 2010, ISSN: 1476-4687

    Schwickart, M.; Huang, X.; Lill, J.R.; Liu, J.; Ferrando, R.; French, D.M.; Maecker, H.; O'Rourke, K.; Bazan, F.; Eastham-Anderson, J.; Yue, P.; Dornan, D.; Huang, D.C.; Dixit, V.M.

  • Evolution of microwave irradiation and Its introduction to the biosciences.

    , 2009, ISSN:

    Lill, J.R.

  • Targeting interferon alpha subtypes in serum: a comparison of analytical approaches to the detection and quantitation of proteins in complex biological matrices.

    Journal of Proteome Research, 2009, ISSN: 1535-3893

    Izrael-Tomasevic, A.; Phu, L.; Phung, Q.T.; Lill, J.R.; Arnott, D.

  • Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.

    Cell, 2009, ISSN: 1097-4172

    Jin, Z.; Li, Y.; Pitti, R.; Lawrence, D.; Pham, V.C.; Lill, J.R.; Ashkenazi, A.

  • The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

    Molecular & Cellular Biology, 2009, ISSN: 1098-5549

    Guelman, S.; Kozuka, K.; Mao, Y.; Pham, V.; Solloway, M.J.; Wang, J.; Wu, J.; Lill, J.R.; Zha, J.

  • Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.

    Cell, 2008, ISSN: 1097-4172

    Newton, K; Matsumoto, M.L.; Wertz, I.E.; Kirkpatrick, D.S.; Lill, J.R.; Tan, J.; Dugger, D.; Gordon, N.; Sidhu, S.S,; Fellouse, F.A.; Komuves, L.; French, D.M.; Ferrando, R.E.; Lam, C.; Compaan, D.; Yu, C.; Bosanac, I.; Hymowitz, S.G.; Kelley, R.F.; Dixit, V.M.

• Education
  • Nottingham Trent University, Nottingham, U.K., Ph.D. – 2000
  • European Masters in Biotechnology, Nottingham, U.K., M.Sc. – 1997
  • University of Warwick, U.K., Biological Sciences, B.Sc. – 1996
• Awards & Honors
  • Awarded the Proteometrics Student Travel Award at the 48th American Society of Mass Spectrometry Ann – 2000
  • Awarded the Michael Barber Prize at the 24th Annual meeting of the British Mass Spectrometry Society – 1999