Publications
Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.
731 results
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| Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study The Lancet Oncology, 2013, ISSN: 1470-2045 View on PubMed |
| A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays PLoS ONE, 2013, ISSN: 1932-6203 View on PubMed |
| Two-in-One antibodies with dual action Fabs Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931 View on PubMed |
| Recapitulating human cancer in a mouse Nature Biotechnology, 2013, ISSN: 1087-0156 View on PubMed |
| Evaluation of Tumor-Size Response Metrics to Predict Overall Survival in Western and Chinese Patients With First-Line Metastatic Colorectal Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X View on PubMed |
| Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier Science Translational Medicine, 2013, ISSN: 1946-6234 View on PubMed |
| EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS PLoS ONE, 2013, ISSN: 1932-6203 View on PubMed |
| Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases Science Signaling, 2013, ISSN: 1945-0877 View on PubMed |
| Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing Drug Metabolism and Disposition, 2013, ISSN: 0090-9556 View on PubMed |
| Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation Journal of Experimental Medicine, 2013, ISSN: 0022-1007 View on PubMed |
| Bispecific antibodies for delivery into the brain Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931 View on PubMed |
| Blockade of individual notch ligands and receptors controls graft-versus-host disease Journal of Clinical Investigation, 2013, ISSN: 0021-9738 View on PubMed |
| OTUB1 modulates c-IAP1 stability to regulate signalling pathways EMBO Journal, 2013, ISSN: 0261-4189 View on PubMed |
| Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623 View on PubMed |
| Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung PLOS GENETICS, 2013, ISSN: 1553-7404 View on PubMed |
| Rer1p maintains ciliary length and signaling by regulating gamma-secretase activity and Foxj1a levels Journal of Cell Biology, 2013, ISSN: 0021-9525 View on PubMed |
| Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR) Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623 View on PubMed |
| Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study Journal of Clinical Pharmacology, 2013, ISSN: 0091-2700 View on PubMed |
| PAR-1 contributes to the innate immune response during viral infection Journal of Clinical Investigation, 2013, ISSN: 0021-9738 View on PubMed |
| Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma Cell, 2013, ISSN: 0092-8674 View on PubMed |
| Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type i serine proteases Fromtransmembrane anchors Journal of Biological Chemistry, 2013, ISSN: 0021-9258 View on PubMed |
| Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia PLoS ONE, 2013, ISSN: 1932-6203 View on PubMed |
| DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424 View on PubMed |
| Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production Journal of Biological Chemistry, 2013, ISSN: 0021-9258 View on PubMed |
| Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery EMBO Reports, 2013, ISSN: 1469-221X View on PubMed |
| Personalizing medicine for autoimmune and inflammatory diseases Nature Immunology, 2013, ISSN: 1529-2908 View on PubMed |
| LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance Blood, 2013, ISSN: 0006-4971 View on PubMed |
| Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer Science Translational Medicine, 2013, ISSN: 1946-6234 View on PubMed |
| Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice PLoS ONE, 2013, ISSN: View on PubMed |
| Phase II Randomized Study of Trastuzumab Emtansine Versus Trastuzumab Plus Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Postive Metastatic Breast Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X View on PubMed |
| Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling Science, 2013, ISSN: 0036-8075 View on PubMed |
| The burden of faulty proofreading in colon cancer Nature Genetics, 2013, ISSN: 1061-4036 View on PubMed |
| Neuroscience: Strength in numbers Nature, 2013, ISSN: 0028-0836 View on PubMed |
| The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling Cell, 2013, ISSN: 0092-8674 View on PubMed |
| Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial The Lancet Oncology, 2013, ISSN: 1470-2045 View on PubMed |
| Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models Cancer Cell, 2013, ISSN: 1535-6108 View on PubMed |
| The Akt DUBbed InAktive Science Signaling, 2013, ISSN: View on PubMed |
| ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Nature Medicine, 2013, ISSN: 1078-8956 View on PubMed |
| Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody-Drug Conjugates Analytical Chemistry, 2013, ISSN: 0003-2700 View on PubMed |
| A tumor-specific stem cell Nature Genetics, 2012, ISSN: 1061-4036 View on PubMed |
| Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways Journal of Cell Biology, 2012, ISSN: 0021-9525 View on PubMed |
| Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Application of a new wall-less plate technology to complex multi-step cell-based investigations using suspension cells Blood, 2012, ISSN: 0006-4971 View on PubMed |
| Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel PLoS ONE, 2012, ISSN: View on PubMed |
| Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Cyanide Anion as a Leaving Group in Nucleophilic Aromatic Substitution: Synthesis of Quaternary Centers at Azine Heterocycles Journal of Organic Chemistry, 2012, ISSN: 0022-3263 View on PubMed |
| Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations Science Translational Medicine, 2012, ISSN: 1946-6234 View on PubMed |
| The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-like Superfamily Biochemistry, 2012, ISSN: View on PubMed |
| Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-amino-1,2,3-thiadiazole Drug Metabolism and Disposition, 2012, ISSN: 0090-9556 View on PubMed |
| The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 Nature Immunology, 2012, ISSN: 1529-2908 View on PubMed |
| Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Potent, selective, and orally bioavailable inhibitors of the Mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Identification of mutant KRas-dependent phenotypes using a panel of isogenic cell lines Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7 Nature Chemical Biology, 2012, ISSN: 1552-4450 View on PubMed |
| Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700 View on PubMed |
| The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletss Journal of Pharmacology and Experimental Therapeutics, 2012, ISSN: 0022-3565 View on PubMed |
| Pharmacokinetics and pharmacodynamics of anti-BR3 monoclonal antibody in mice Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias Cell, 2012, ISSN: 0092-8674 View on PubMed |
| Improving risk assessment Science Translational Medicine, 2012, ISSN: 1946-6234 View on PubMed |
| Furin-cleaved PCSK9 is active and modulates LDL receptor and serum cholesterol levels Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer Molecular Cell, 2012, ISSN: View on PubMed |
| Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci American Journal of Human Genetics, 2012, ISSN: 0002-9297 View on PubMed |
| Characterization of rat liver proteins adducted by reactive metabolites of menthofuran Chemical Research in Toxicology, 2012, ISSN: 0893-228X View on PubMed |
| Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity PloS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function Cell, 2012, ISSN: 0092-8674 View on PubMed |
| Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Evaluation of semi-homogeneous assay formats for dual-specificity antibodies Journal of Immunological Methods, 2012, ISSN: 1872-7905 View on PubMed |
| Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial Nature Reviews, 2012, ISSN: 1474-1733 View on PubMed |
| Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer New England Journal of Medicine, 2012, ISSN: 0028-4793 View on PubMed |
| Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification Cell, 2012, ISSN: 0092-8674 View on PubMed |
| Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT Blood, 2012, ISSN: 0006-4971 View on PubMed |
| Development of an ELISA based bridging assay as a surrogate measure of ADCC Journal of Immunological Methods, 2012, ISSN: 0022-1759 View on PubMed |
| Genomic landscape of liver cancer Nature Genetics, 2012, ISSN: 1061-4036 View on PubMed |
| Pharmacokinetic Considerations for Antibody Drug Conjugates Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial The Lancet Oncology, 2012, ISSN: 1470-2045 View on PubMed |
| Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human Drug Metabolism and Disposition, 2012, ISSN: 0090-9556 View on PubMed |
| Childhood disorders of the synapse: Challenges and opportunities Science Translational Medicine, 2012, ISSN: 1946-6234 View on PubMed |
| Compensatory dendritic cell development mediated by BATF-IRF interactions Nature, 2012, ISSN: 0028-0836 View on PubMed |
| Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1-IRF Complexes Science, 2012, ISSN: 0036-8075 View on PubMed |
| Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236 View on PubMed |
| Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 is Linked to TNF-ALPHA Pharmacology Toxicological Sciences, 2012, ISSN: 1096-0929 View on PubMed |
| S1P1 inhibits sprouting angiogenesis during vascular development Development, 2012, ISSN: 0950-1991 View on PubMed |
| Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation Journal of Clinical Investigation, 2012, ISSN: 0021-9738 View on PubMed |
| The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer Nature Genetics, 2012, ISSN: 1061-4036 View on PubMed |
| Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Recurrent R-spondin fusions in colon cancer Nature, 2012, ISSN: 0028-0836 View on PubMed |
| Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Blood, 2012, ISSN: 0006-4971 View on PubMed |
| Real-time quantification of antibody-siRNA conjugate in serum by antigen-capture RT-PCR Analytical Biochemistry, 2012, ISSN: 0003-2697 View on PubMed |
| The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site Structure, 2012, ISSN: 0969-2126 View on PubMed |
| Profiling Antibody Drug Conjugate Positional Isomers: A System-of-Equations Approach Analytical Chemistry, 2012, ISSN: 0003-2700 View on PubMed |
| Molecular basis for negative regulation of the glucagon receptor Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| Effectiveness of First-Line Management Strategies for Stage I Follicular Lymphoma: Analysis of the National LymphoCare Study Journal of Clinical Oncology, 2012, ISSN: 0732-183X View on PubMed |
| Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 Nature, 2012, ISSN: 0028-0836 View on PubMed |
| Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700 View on PubMed |
| Phosphorylation of NLRC4 is critical for inflammasome activation Nature, 2012, ISSN: 0028-0836 View on PubMed |
| The genetics of type I interferon in systemic lupus erythematosus Current Opinion in Immunology, 2012, ISSN: View on PubMed |
| Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation Science, 2012, ISSN: 0036-8075 View on PubMed |
| Potent and highly selective benzimidazole inhibitors of PI3-kinase delta Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature, 2012, ISSN: View on PubMed |
| Pari passu dimers of dimers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors Nature, 2012, ISSN: View on PubMed |
| Evaluation of an Accurate Mass Approach for the Simultaneous Detection of Drug and Metabolite Distributions via Whole-Body Mass Spectrometric Imaging Analytical Chemistry, 2012, ISSN: 0003-2700 View on PubMed |
| CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair Blood, 2012, ISSN: 0006-4971 View on PubMed |
| Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease Blood, 2012, ISSN: 0006-4971 View on PubMed |
| Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach Journal of Organic Chemistry, 2012, ISSN: 0022-3263 View on PubMed |
| Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Quantification and Characterization of Micrometer and Submicrometer Subvisible Particles in Protein Therapeutics by Use of a Suspended Microchannel Resonator. Analytical Chemistry, 2012, ISSN: 0003-2700 |
| Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells Blood, 2012, ISSN: View on PubMed |
| Identification and Characterization of Buried Unpaired Cysteines in a Recombinant Monoclonal IgG1 Antibody Analytical Chemistry, 2012, ISSN: 0003-2700 View on PubMed |
| Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth. Cancer cell, 2012, ISSN: 1535-6108 |
| The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients British Journal of Clinical Pharmacology, 2012, ISSN: 0007-1188 View on PubMed |
| Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO journal, 2012, ISSN: 0261-4189 View on PubMed |
| Reversible modification of APC with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease Journal of Clinical Investigation, 2012, ISSN: 0021-9738 View on PubMed |
| Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236 View on PubMed |
| Reply to "On the differentiation of mouse IgE(+) cells" Nature Immunology, 2012, ISSN: 1529-2908 View on PubMed |
| Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection Analytical Chemistry, 2012, ISSN: 0003-2700 View on PubMed |
| Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nature Chemical Biology, 2012, ISSN: 1552-4450 View on PubMed |
| Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma New England Journal of Medicine, 2012, ISSN: 1533-4406 |
| FOXO3a and β-catenin co-localization: double trouble in colon cancer? Nature Medicine, 2012, ISSN: 1078-8956 View on PubMed |
| Structural and Functional Analysis of HtrA1 and Its Subdomains Structure, 2012, ISSN: 0969-2126 View on PubMed |
| Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b + Gr1 + cells: Key role of Stat3 signaling Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2 -Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine Journal of Clinical Oncology, 2012, ISSN: 0732-183X View on PubMed |
| Origin of Immunoglobulin Isotype Switching Current Biology, 2012, ISSN: 0960-9822 View on PubMed |
| Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery Drug Metabolism and Disposition, 2012, ISSN: View on PubMed |
| Clinical Implications of Pathophysiological and Demographic Covariates on the Population Pharmacokinetics of Trastuzumab Emtansine, a HER2-Targeted Antibody-Drug Conjugate, in Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700 View on PubMed |
| Quantification of Antiangiogenic and Antivascular Drug Activity by Kinetic Analysis of DCE-MRI Data Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236 View on PubMed |
| Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling. Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 |
| Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models PLoS One, 2012, ISSN: 1932-6203 View on PubMed |
| An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt Science Signaling, 2012, ISSN: 1937-9145 View on PubMed |
| Bevacizumab in Combination With Chemotherapy as First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial Journal of Clinical Oncology, 2012, ISSN: 0732-183X View on PubMed |
| Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis Current Opinion in Genetics & Development, 2012, ISSN: 0959-437X View on PubMed |
| Translation levels control multi-spanning membrane protein expression PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Journal of Clinical Oncology, 2012, ISSN: 0732-183X View on PubMed |
| Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis Developmental Cell, 2012, ISSN: 1534-5807 View on PubMed |
| Inhibiting alternative pathway complement activation by targeting the factor D exosite Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R Structure, 2012, ISSN: 0969-2126 View on PubMed |
| Cancer: Clinical trials unite mice and humans Nature, 2012, ISSN: 0028-0836 View on PubMed |
| Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors Science Signaling, 2012, ISSN: 1945-0877 View on PubMed |
| Small-Molecule Ligands Bind to a Distinct Pocket in Ras and Inhibit SOS-Mediated Nucleotide Exchange Activity Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424 View on PubMed |
| Drug-Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug-Drug Interaction Prediction Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| In Vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease PLoS ONE, 2012, ISSN: View on PubMed |
| Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses Pharmaceutical Research, 2012, ISSN: 0724-8741 View on PubMed |
| Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells PLoS Pathogens, 2012, ISSN: 1553-7366 View on PubMed |
| An evolutionary conserved PILRα domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| Engineering upper hinge improves stability and effector function of a human IgG1 Journal of Biological Chemistry, 2012, ISSN: 0021-9258 View on PubMed |
| An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo PloS ONE, 2012, ISSN: View on PubMed |
| IgE(+) memory B cells and plasma cells generated through a germinal-center pathway Nature Immunology, 2012, ISSN: 1529-2908 View on PubMed |
| Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623 View on PubMed |
| Death Receptors DR6 and TROY Regulate Brain Vascular Development Developmental cell, 2012, ISSN: 1534-5807 |
| Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling Nature Immunology, 2012, ISSN: 1529-2908 View on PubMed |
| Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells Development, 2012, ISSN: 0950-1991 View on PubMed |
| Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin Journal of Clinical Investigation, 2012, ISSN: 0021-9738 View on PubMed |
| High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency PLoS Genetics, 2012, ISSN: 1553-7390 View on PubMed |
| Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates Nature Biotechnology, 2012, ISSN: 1087-0156 View on PubMed |
| Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer Nature Medicine, 2012, ISSN: 1078-8956 View on PubMed |
| A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation Nature Immunology, 2012, ISSN: 1529-2908 View on PubMed |
| Antibody-mediated Inhibition of Fibroblast Growth Factor-19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys Toxicological Sciences, 2012, ISSN: 1096-0929 View on PubMed |
| Protecting Group Free, Stereocontrolled Synthesis of beta-Halo-enamides Journal of Organic Chemistry, 2012, ISSN: 0022-3263 View on PubMed |
| Signaling: An oxysterol ligand for Smoothened Nature Chemical Biology, 2012, ISSN: 1552-4450 View on PubMed |
| DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy Developmental Cell, 2012, ISSN: 1534-5807 View on PubMed |
| Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural & Molecular Biology, 2012, ISSN: 1545-9985 View on PubMed |
| A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C PLoS ONE, 2012, ISSN: 1932-6203 View on PubMed |
| Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis Science, 6 Jan 2012, v335(6064), p89-92, ISSN: 0036-8075, eISSN: 1095-9203 View on PubMed |
| A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain Nature Cell Biology, 2012, ISSN: 1465-7392 View on PubMed |
| Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury Nature Medicine, 2012, ISSN: 1078-8956 View on PubMed |
| The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly Cell, 26 Dec 2011, v147(6), p1309-23, ISSN: 0092-8674 View on PubMed |
| The A-MYSM Power of Deubiquitinases Immunity, 23 Dec 2011, v35(6), p847-849, ISSN: 1074-7613 View on PubMed |
| Cancer immunotherapy comes of age Nature, 21 Dec 2011, v480, p480-489, ISSN: 1476-4687 View on PubMed |
| Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 Science Translational Medicine, 2011, ISSN: 1946-6234 View on PubMed |
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