/ Scientists

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

988 results

Title
IMMUNOTHERAPY. Outsourcing the immune response to cancer Science, 2016, ISSN: 0036-8075

Yadav, Mahesh; Delamarre, Lélia

Isolation and Characterization of Monoclonal Antibody Charge Variants by Free Flow Isoelectric Focusing Analytical chemistry, 2016, ISSN: 0003-2700

Hosken, Brian D; Li, Charlene; Mullappally, Berny; Co, Carl; Zhang, Boyan

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model. Drug Metabolism and Disposition, 2016,

Almond, Lisa M.; Mukadam, Sophie; Gardner, Iain; Okialda, Krystle; Wong, Susan; Hatley, Oliver; Tay, Suzanne; Rowland-Yeo, Karen; Jamei, Masoud; Rostami-Hodjegan, Amin; Kenny, Jane R.

Does caspase-12 suppress inflammasome activation? Nature, 2016, ISSN: 0028-0836

Vande Walle, Lieselotte; Jiménez Fernández, Daniel; Demon, Dieter; Van Laethem, Naomi; Van Hauwermeiren, Filip; Van Gorp, Hanne; Van Opdenbosch, Nina; Kayagaki, Nobuhiko; Lamkanfi, Mohamed

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells Nature chemical biology, 2016, ISSN: 1552-4450

Vinogradova, Maia; Gehling, Victor S; Gustafson, Amy; Arora, Shilpi; Tindell, Charles A; Wilson, Catherine; Williamson, Kaylyn E; Guler, Gulfem D; Gangurde, Pranoti; Manieri, Wanda; Busby, Jennifer; Flynn, E Megan; Lan, Fei; Kim, Hyo-Jin; Odate, Shobu; Cochran, Andrea G; Liu, Yichin; Wongchenko, Matthew; Yang, Yibin; Cheung, Tommy K; Maile, Tobias M; Lau, Ted; Costa, Michael; Hegde, Ganapati V; Jackson, Erica; Pitti, Robert; Arnott, David; Bailey, Christopher; Bellon, Steve; Cummings, Richard T; Albrecht, Brian K; Harmange, Jean-Christophe; Kiefer, James R; Trojer, Patrick; Classon, Marie

Prediction and Quantification of Splice Events from RNA-Seq Data PloS one, 2016, ISSN: 1932-6203

Goldstein, Leonard D; Cao, Yi; Pau, Gregoire; Lawrence, Michael; Wu, Thomas D; Seshagiri, Somasekar; Gentleman, Robert

Reproducible pharmacogenomic profiling of cancer cell line panels Nature, 2016, ISSN: 0028-0836

Haverty, Peter M; Lin, Eva; Tan, Jenille; Yu, Yihong; Lam, Billy; Lianoglou, Steve; Neve, Richard M; Martin, Scott; Settleman, Jeff; Yauch, Robert L; Bourgon, Richard

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling Blood, 2016, ISSN: 0006-4971

Le Gall, Sylvain M; Szabo, Roman; Lee, Melody; Kirchhofer, Daniel; Craik, Charles S; Bugge, Thomas H; Camerer, Eric

A Sensitive Mutation Screening Method Supporting Cell Line Development for Biotherapeutics Analytical biochemistry, 2016, ISSN: 0003-2697

Valisheva, Ildana; Harris, Reed J; Zhu-Shimoni, Judith

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making Chemical research in toxicology, 2016, ISSN: 0893-228X

Dambach, Donna M; Misner, Dinah; Brock, Mathew; Fullerton, Aaron; Proctor, William; Maher, Jonathan; Lee, Dong; Ford, Kevin; Diaz, Dolores

The Complexity of Translating Anti-angiogenesis Therapy from Basic Science to the Clinic Developmental cell, 2016, ISSN: 1534-5807

Ye, Weilan

The Human Vaccines Project: A roadmap for cancer vaccine development Science Translational Medicine, 2016, ISSN: 1946-6234

Romero, Pedro; Banchereau, Jacques; Bhardwaj, Nina; Cockett, Mark; Disis, Mary L; Dranoff, Glenn; Gilboa, Eli; Hammond, Scott A; Hershberg, Robert; Korman, Alan J; Kvistborg, Pia; Melief, Cornelis; Mellman, Ira; Palucka, A Karolina; Redchenko, Irina; Robins, Harlan; Sallusto, Federica; Schenkelberg, Theodore; Schoenberger, Stephen; Sosman, Jeffrey; Türeci, Özlem; Van den Eynde, Benoît; Koff, Wayne; Coukos, George

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells Cancer cell, 2016, ISSN: 1535-6108

Pusapati, Raju V; Daemen, Anneleen; Wilson, Catherine; Sandoval, Wendy; Gao, Min; Haley, Benjamin; Baudy, Andreas R; Hatzivassiliou, Georgia; Evangelista, Marie; Settleman, Jeff

Immunoglobulin isotype knowledge and application to Fc engineering Current opinion in immunology, 2016, ISSN: 0952-7915

Brezski, Randall J; Georgiou, George

Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer Journal of clinical oncology, 2016, ISSN: 0732-183X

Schmid, Peter; Pinder, Sarah E; Wheatley, Duncan; Macaskill, Jane; Zammit, Charles; Hu, Jennifer; Price, Robert; Bundred, Nigel; Hadad, Sirwan; Shia, Alice; Sarker, Shah-Jalal; Lim, Louise; Gazinska, Patrycja; Woodman, Natalie; Korbie, Darren; Trau, Matt; Mainwaring, Paul; Gendreau, Steven; Lackner, Mark R; Derynck, Mika; Wilson, Timothy R; Butler, Hannah; Earl, Gemma; Parker, Peter; Purushotham, Arnie; Thompson, Alastair

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade Immunity, 2016, ISSN: 1074-7613

Ebert, Peter J R; Cheung, Jeanne; Yang, Yagai; McNamara, Erin; Hong, Rebecca; Moskalenko, Marina; Gould, Stephen E; Maecker, Heather; Irving, Bryan A; Kim, Jeong M; Belvin, Marcia; Mellman, Ira

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 Cancer cell, 2016, ISSN: 1535-6108

Foster, Scott A; Whalen, Daniel M; Özen, Ayşegül; Wongchenko, Matthew J; Yin, JianPing; Yen, Ivana; Schaefer, Gabriele; Mayfield, John D; Chmielecki, Juliann; Stephens, Philip J; Albacker, Lee A; Yan, Yibing; Song, Kyung; Hatzivassiliou, Georgia; Eigenbrot, Charles; Yu, Christine; Shaw, Andrey S; Manning, Gerard; Skelton, Nicholas J; Hymowitz, Sarah G; Malek, Shiva

A call for industry to embrace green biopharma Nature biotechnology, 2016, ISSN: 1087-0156

Budzinski, Kristi L; Koenig, Stefan G; O'Connor, Deborah A; Wu, Tse-Sung

Voices of biotech Nature biotechnology, 2016, ISSN: 1087-0156

Amit, Ido; Baker, David; Barker, Roger; Berger, Bonnie; Bertozzi, Carolyn; Bhatia, Sangeeta; Biffi, Alessandra; Demichelis, Francesca; Doudna, Jennifer; Dowdy, Steven F; Endy, Drew; Helmstaedter, Moritz; Junca, Howard; June, Carl; Kamb, Sasha; Khvorova, Anastasia; Kim, Dae-Hyeong; Kim, Jin-Soo; Krishnan, Yamuna; Lakadamyali, Melike; Lappalainen, Tuuli; Lewin, Sharon; Liao, James; Loman, Nick; Lundberg, Emma; Lynd, Lee; Martin, Cathie; Mellman, Ira; Miyawaki, Atsushi; Mummery, Christine; Nelson, Karen; Paz, Jeanne; Peralta-Yahya, Pamela; Picotti, Paola; Polyak, Kornelia; Prather, Kristala; Qin, Jun; Quake, Stephen; Regev, Aviv; Rogers, John A; Shetty, Reshma; Sommer, Morten; Stevens, Molly; Stolovitzky, Gustavo; Takahashi, Masayo; Tang, Fuchou; Teichmann, Sarah; Torres-Padilla, Maria-Elena; Tripathi, Leena; Vemula, Praveen; Verdine, Greg; Vollmer, Frank; Wang, Jun; Ying, Jackie Y; Zhang, Feng; Zhang, Tian

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma Nature genetics, 2016, ISSN: 1061-4036

Bonilla, Ximena; Parmentier, Laurent; King, Bryan; Bezrukov, Fedor; Kaya, Gürkan; Zoete, Vincent; Seplyarskiy, Vladimir B; Sharpe, Hayley J; McKee, Thomas; Letourneau, Audrey; Ribaux, Pascale G; Popadin, Konstantin; Basset-Seguin, Nicole; Chaabene, Rouaa Ben; Santoni, Federico A; Andrianova, Maria A; Guipponi, Michel; Garieri, Marco; Verdan, Carole; Grosdemange, Kerstin; Sumara, Olga; Eilers, Martin; Aifantis, Iannis; Michielin, Olivier; de Sauvage, Frederic J; Antonarakis, Stylianos E; Nikolaev, Sergey I

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma Journal of clinical oncology, 2016, ISSN: 0732-183X

Powles, Thomas; Lackner, Mark R; Oudard, Stéphane; Escudier, Bernard; Ralph, Christy; Brown, Janet E; Hawkins, Robert E; Castellano, Daniel; Rini, Brian I; Staehler, Michael D; Ravaud, Alain; Lin, Wei; O'Keeffe, Bridget; Wang, Yulei; Lu, Shan; Spoerke, Jill M; Huw, Ling-Yuh; Byrtek, Michelle; Zhu, Rui; Ware, Joseph A; Motzer, Robert J

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations Nature genetics, 2016, ISSN: 1061-4036

Bueno, Raphael; Stawiski, Eric W; Goldstein, Leonard D; Durinck, Steffen; De Rienzo, Assunta; Modrusan, Zora; Gnad, Florian; Nguyen, Thong T; Jaiswal, Bijay S; Chirieac, Lucian R; Sciaranghella, Daniele; Dao, Nhien; Gustafson, Corinne E; Munir, Kiara J; Hackney, Jason A; Chaudhuri, Amitabha; Gupta, Ravi; Guillory, Joseph; Toy, Karen; Ha, Connie; Chen, Ying-Jiun; Stinson, Jeremy; Chaudhuri, Subhra; Zhang, Na; Wu, Thomas D; Sugarbaker, David J; de Sauvage, Frederic J; Richards, William G; Seshagiri, Somasekar

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma Pharmaceutical Research, 2016, ISSN: 0724-8741

Mao, Jialin; Tay, Suzanne; Khojasteh, Cyrus S; Chen, Yuan; Hop, Cornelis E C A; Kenny, Jane R

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function Neuron, 2016, ISSN: 0896-6273

Hackos, David H; Lupardus, Patrick J; Grand, Teddy; Chen, Yelin; Wang, Tzu-Ming; Reynen, Paul; Gustafson, Amy; Wallweber, Heidi J A; Volgraf, Matthew; Sellers, Benjamin D; Schwarz, Jacob B; Paoletti, Pierre; Sheng, Morgan; Zhou, Qiang; Hanson, Jesse E

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters Cell stem cell, 2016,

Tetteh, Paul W; Basak, Onur; Farin, Henner F; Wiebrands, Kay; Kretzschmar, Kai; Begthel, Harry; van den Born, Maaike; Korving, Jeroen; de Sauvage, Frederic; van Es, Johan H; van Oudenaarden, Alexander; Clevers, Hans

Fatty acylation of Wnt proteins Nature chemical biology, 2016, ISSN: 1552-4450

Nile, Aaron H; Hannoush, Rami N

Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease Cell, 2016, ISSN: 0092-8674

Yang, Chiao-Wen; Hojer, Caroline D; Zhou, Meijuan; Wu, Xiumin; Wuster, Arthur; Lee, Wyne P; Yaspan, Brian L; Chan, Andrew C

Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies PloS one, 2016, ISSN: 1932-6203

Wedemeyer, Heiner; Forns, Xavier; Hézode, Christophe; Lee, Samuel S; Scalori, Astrid; Voulgari, Athina; Le Pogam, Sophie; Nájera, Isabel; Thommes, James A

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function Nature, 2016, ISSN: 0028-0836

Storm, Elaine E; Durinck, Steffen; de Sousa e Melo, Felipe; Tremayne, Jarrod; Kljavin, Noelyn; Tan, Christine; Ye, Xiaofen; Chiu, Cecilia; Pham, Thinh; Hongo, Jo-Anne; Bainbridge, Travis; Firestein, Ron; Blackwood, Elizabeth; Metcalfe, Ciara; Stawiski, Eric W; Yauch, Robert L; Wu, Yan; de Sauvage, Frederic J

Ubiquitin in the activation and attenuation of innate antiviral immunity Journal of experimental medicine, 2015, ISSN: 0022-1007

Heaton, Steven M; Borg, Natalie A; Dixit, Vishva M

Attitudes and Stereotypes in Lung Cancer versus Breast Cancer PloS one, 2015, ISSN: 1932-6203

Sriram, N; Mills, Jennifer; Lang, Edward; Dickson, Holli K; Hamann, Heidi A; Nosek, Brian A; Schiller, Joan H

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Science, 2015, ISSN: 0036-8075

Ahuja, Shivani; Mukund, Susmith; Deng, Lunbin; Khakh, Kuldip; Chang, Elaine; Ho, Hoangdung; Shriver, Stephanie; Young, Clint; Lin, Sophia; Johnson, J P, Jr; Wu, Ping; Li, Jun; Coons, Mary; Tam, Christine; Brillantes, Bobby; Sampang, Honorio; Mortara, Kyle; Bowman, Krista K; Clark, Kevin R; Estevez, Alberto; Xie, Zhiwei; Verschoof, Henry; Grimwood, Michael; Dehnhardt, Christoph; Andrez, Jean-Christophe; Focken, Thilo; Sutherlin, Daniel P; Safina, Brian S; Starovasnik, Melissa A; Ortwine, Daniel F; Franke, Yvonne; Cohen, Charles J; Hackos, David H; Koth, Christopher M; Payandeh, Jian

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation Nature, 2015, ISSN: 0028-0836

Wertz, Ingrid E; Newton, Kim; Seshasayee, Dhaya; Kusam, Saritha; Lam, Cynthia; Zhang, Juan; Popovych, Nataliya; Helgason, Elizabeth; Schoeffler, Allyn; Jeet, Surinder; Ramamoorthi, Nandhini; Kategaya, Lorna; Newman, Robert J; Horikawa, Keisuke; Dugger, Debra; Sandoval, Wendy; Mukund, Susmith; Zindal, Anuradha; Martin, Flavius; Quan, Clifford; Tom, Jeffrey; Fairbrother, Wayne J; Townsend, Michael; Warming, Søren; DeVoss, Jason; Liu, Jinfeng; Dueber, Erin; Caplazi, Patrick; Lee, Wyne P; Goodnow, Christopher C; Balazs, Mercedesz; Yu, Kebing; Kolumam, Ganesh; Dixit, Vishva M

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation Immunity, 2015, ISSN: 1074-7613

Pikor, Natalia B; Astarita, Jillian L; Summers-Deluca, Leslie; Galicia, Georgina; Qu, Joy; Ward, Lesley A; Armstrong, Susan; Dominguez, Claudia X; Malhotra, Deepali; Heiden, Brendan; Kay, Robert; Castanov, Valera; Touil, Hanane; Boon, Louis; O'Connor, Paul; Bar-Or, Amit; Prat, Alexandre; Ramaglia, Valeria; Ludwin, Samuel; Turley, Shannon J; Gommerman, Jennifer L

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies Neuron, 2015,

Y. Joy Yu Zuchero; Xiaocheng Chen; Nga Bien-Ly; Daniela Bumbaca; Raymond K. Tong; Xiaoying Gao; Shuo Zhang; Kwame Hoyte; Wilman Luk; Melanie A. Huntley; Lilian Phu; Christine Tan; Dara Kallop; Robby M. Weimer; Yanmei Lu; Donald S. Kirkpatrick; James A. Ernst; Ben Chih; Mark S. Dennis; Ryan J. Watts

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Nature genetics, 2015, ISSN: 1061-4036

Zhou, Qing; Wang, Hongying; Schwartz, Daniella M; Stoffels, Monique; Park, Yong Hwan; Zhang, Yuan; Yang, Dan; Demirkaya, Erkan; Takeuchi, Masaki; Tsai, Wanxia Li; Layons, Jonathan J; Yu, Xiaomin; Ouyang, Claudia; Chen, Celeste; Chin, David T; Zaal, Kristien; Chandrasekharappa, Settara C; P Hanson, Eric; Yu, Zhen; Mullikin, James C; Hasni, Sarfaraz A; Wertz, Ingrid E; Ombrello, Amanda K; Stone, Deborah L; Hoffmann, Patrycja; Jones, Anne; Barham, Beverly K; Leavis, Helen L; van Royen-Kerkof, Annet; Sibley, Cailin; Batu, Ezgi D; Gül, Ahmet; Siegel, Richard M; Boehm, Manfred; Milner, Joshua D; Ozen, Seza; Gadina, Massimo; Chae, JaeJin; Laxer, Ronald M; Kastner, Daniel L; Aksentijevich, Ivona

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1 Cell, 2015, ISSN: 0092-8674

Suriben, Rowena; Kaihara, Kelly A.; Paolino, Magdalena; Reichelt, Mike; Kummerfeld, Sarah K.; Modrusan, Zora; Dugger, Debra L.; Newton, Kim; Sagolla, Meredith; Webster, Joshua; Liu , Jinfeng; Hebrok, Matthias; Dixit, Vishva M.

Primary results of the health-related quality of life assessment from the phase III gadolin study of obinutuzumab plus bendamustine compared with bendamustine alone in patients with rituximab-refractory, indolent non-hodgkin lymphoma Blood, 2015, ISSN: 0006-4971

Cheson, Bruce D.; Trask, Peter C.; Gribben, John; Dimier, Natalie; Kimby, Eva; Lugtenburg, Pieternella J.; Thieblemont, Catherine; Fritsch, Elisabeth Wassner; Sehn, Laurie H.; Cheson, B.D.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response Science signaling, 2015,

Sun, Yonglian; Peng, Ivan; Webster, Joshua D; Suto, Eric; Lesch, Justin; Wu, Xiumin; Senger, Kate; Francis, George; Barrett, Kathy; Collier, Jenna L; Burch, Jason D; Zhou, Meijuan; Chen, Yuan; Chan, Connie; Eastham-Anderson, Jeff; Ngu, Hai; Li, Olga; Staton, Tracy; Havnar, Charles; Jaochico, Allan; Jackman, Janet; Jeet, Surinder; Riol-Blanco, Lorena; Wu, Lawren C; Choy, David F; Arron, Joseph R; McKenzie, Brent S; Ghilardi, Nico; Ismaili, Moulay Hicham Alaoui; Pei, Zhonghua; DeVoss, Jason; Austin, Cary D; Lee, Wyne P; Zarrin, Ali A

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets Journal of Clinical Investigation, 2015,

Hitchcock, Jessica R.; Cook, Charlotte N.; Bobat, Saeeda; Ross, Ewan A.; Flores-Langarica, Adriana; Lowe, Kate L.; Khan, Mahmood; Coral Dominguez-Medina, C.; Lax, Sian; Carvalho-Gaspar, Manuela; Hubscher, Stefan; Ed Rainger, G.; Cobbold, Mark; Buckley, Christopher D.; Mitchell, Tim J.; Mitchell, Andrea; Jones, Nick D.; Van Rooijen, N.; Kirchhofer, Daniel; Henderson, Ian R.; Adams, David H.; Watson, Steve P.; Cunningham, Adam F.

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2 Science, 2015,

Alexander Jaworski; Irene Tom; Raymond K. Tong; Holly K. Gildea; Alexander W. Koch; Lino C. Gonzalez; Marc Tessier-Lavigne

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung. Nature, 2015, ISSN: 0028-0836

Lafkas, Daniel; Shelton, Amy; Chiu, Cecilia; de Leon Boenig, Gladys; Chen, Yongmei; Stawicki, Scott S; Siltanen, Christian; Reichelt, Mike; Zhou, Meijuan; Wu, Xiumin; Eastham-Anderson, Jeffrey; Moore, Heather; Roose-Girma, Meron; Chinn, Yvonne; Hang, Julie Q; Warming, Søren; Egen, Jackson; Lee, Wyne P; Austin, Cary; Wu, Yan; Payandeh, Jian; Lowe, John B; Siebel, Christian W

Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer Science translational medicine, 2015, ISSN: 1946-6234

Junttila, Melissa R; Mao, Weiguang; Wang, Xi; Wang, Bu-Er; Pham, Thinh; Flygare, John; Yu, Shang-Fan; Yee, Sharon; Goldenberg, David; Fields, Carter; Eastham-Anderson, Jeffrey; Singh, Mallika; Vij, Rajesh; Hongo, Jo-Anne; Firestein, Ron; Schutten, Melissa; Flagella, Kelly; Polakis, Paul; Polson, Andrew G

Outcome-Driven Cluster Analysis with Application to Microarray Data PloS one, 2015, ISSN: 1932-6203

Hsu, Jessie J; Finkelstein, Dianne M; Schoenfeld, David A

The Hedgehog Hold on Homeostasis Cell stem cell, 2015,

Metcalfe, Ciara; Siebel, Christian W

Novel antibody-antibiotic conjugate eliminates intracellular S. aureus Nature, 2015, ISSN: 0028-0836

Lehar, Sophie M; Pillow, Thomas; Xu, Min; Staben, Leanna; Kajihara, Kimberly K; Vandlen, Richard; DePalatis, Laura; Raab, Helga; Hazenbos, Wouter L; Hiroshi Morisaki, J; Kim, Janice; Park, Summer; Darwish, Martine; Lee, Byoung-Chul; Hernandez, Hilda; Loyet, Kelly M; Lupardus, Patrick; Fong, Rina; Yan, Donghong; Chalouni, Cecile; Luis, Elizabeth; Khalfin, Yana; Plise, Emile; Cheong, Jonathan; Lyssikatos, Joseph P; Strandh, Magnus; Koefoed, Klaus; Andersen, Peter S; Flygare, John A; Wah Tan, Man; Brown, Eric J; Mariathasan, Sanjeev

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus Nature Genetics, 2015, ISSN: 1061-4036

Bentham, James; Morris, David L; Cunninghame Graham, Deborah S; Pinder, Christopher L; Tombleson, Philip; Behrens, Timothy W; Martín, Javier; Fairfax, Benjamin P; Knight, Julian C; Chen, Lingyan; Replogle, Joseph; Syvänen, Ann-Christine; Rönnblom, Lars; Graham, Robert R; Wither, Joan E; Rioux, John D; Alarcón-Riquelme, Marta E; Vyse, Timothy J

Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies Neuron, 2015, ISSN: 0896-6273

Bien-Ly, Nga; Boswell, C Andrew; Jeet, Surinder; Beach, Thomas G; Hoyte, Kwame; Luk, Wilman; Shihadeh, Vera; Ulufatu, Sheila; Foreman, Oded; Lu, Yanmei; DeVoss, Jason; van der Brug, Marcel; Watts, Ryan J

Absolute Quantitation of Intact Recombinant Antibody Product Variants Using Mass Spectrometry Analytical chemistry, 2015, ISSN: 0003-2700

Macchi, Frank D; Yang, Feng; Li, Charlene; Wang, Chenchen; Dang, Anh Nguyen; Marhoul, Joseph C; Zhang, Hui-Min; Tully, Timothy; Liu, Hongbin; Yu, X Christopher; Michels, David A

Randomized phase II study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia (CLL) Blood, 2015, ISSN: 0006-4971

Byrd, John C; Flynn, Joseph; Kipps, Thomas J; Boxer, Michael; Kolibaba, Kathryn S; Carlile, David J; Fingerle-Rowson, Guenter; Tyson, Nicola; Hirata, Jamie; Sharman, Jeff P

Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program PloS one, 2015, ISSN: 1932-6203

Morley, Roland; Cardenas, Alison; Hawkins, Peter; Suzuki, Yasuyo; Paton, Virginia; Phan, See-Chun; Merchant, Mark; Hsu, Jessie; Yu, Wei; Xia, Qi; Koralek, Daniel; Luhn, Patricia; Aldairy, Wassim

Assessment of disease related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis Journal of clinical pharmacology, 2015, ISSN: 0091-2700

Wei, Xiaohui; Kenny, Jane R; Dickmann, Leslie; Maciuca, Romeo; Looney, Carrie; Tang, Meina T

The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst PloS one, 2015, ISSN: 1932-6203

Coady, Alison; Xu, Min; Phung, Qui; Cheung, Tommy K; Bakalarski, Corey; Alexander, Mary Kate; Lehar, Sophie M; Kim, Janice; Park, Summer; Tan, Man-Wah; Nishiyama, Mireille

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression Science, 2015, ISSN: 0036-8075

Hung, T; Pratt, G; Sundararaman, B; Townsend, M J; Chaivorapol, C; Bhangale, T; Graham, R R; Ortmann, W; Criswell, L A; Yeo, G; Behrens, T W

Caspase-11 cleaves Gasdermin-D for non-canonical inflammasome signaling Nature, 2015,

Nobuhiko Kayagaki; Irma B. Stowe; Bettina L. Lee; Karen O’Rourke; Keith Anderson; Soren Warming; Trinna Cuellar; Benjamin Haley; Merone Roose-Girma; Qui T. Phung; Peter S. Liu; Jennie R. Lill; Hong Li; Jiansheng Wu; Sarah Kummerfeld; Juan Zhang; Wyne P. Lee; Scott J. Snipas; Guy S. Salvesen; Lucy X. Morris; Linda Fitzgerald; Yafei Zhang; Edward M. Bertram; Christopher C. Goodnow; Vishva M. Dixit

Parkinson's disease: From human genetics to clinical trials Science translational medicine, 2015, ISSN: 1946-6234

van der Brug, Marcel P; Singleton, Andrew; Gasser, Thomas; Lewis, Patrick A

Bevacizumab dosing strategy in pediatric cancer patients based on population pharmacokinetic analysis with external validation British journal of clinical pharmacology, 2015, ISSN: 0306-5251

Han, Kelong; Peyret, Thomas; Quartino, Angelica; Gosselin, Nathalie H; Gururangan, Sridharan; Daw, Najat C; Navid, Fariba; Jin, Jin; Allison, David E

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma Science translational medicine, 2015, ISSN: 1946-6234

Choy, David F; Hart, Kevin M; Borthwick, Lee A; Shikotra, Aarti; Nagarkar, Deepti R; Siddiqui, Salman; Jia, Guiquan; Ohri, Chandra M; Doran, Emma; Vannella, Kevin M; Butler, Claire A; Hargadon, Beverley; Sciurba, Joshua C; Gieseck, Richard L; Thompson, Robert W; White, Sandra; Abbas, Alexander R; Jackman, Janet; Wu, Lawren C; Egen, Jackson G; Heaney, Liam G; Ramalingam, Thirumalai R; Arron, Joseph R; Wynn, Thomas A; Bradding, Peter

Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-Independent Dimers Journal of Biological Chemistry, 2015, ISSN: 0021-9258

Comps-Agrar, Laëtitia; Dunshee, Diana Ronai; Eaton, Dan L; Sonoda, Junichiro

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4 PloS one, 2015, ISSN: 1932-6203

Kasperkiewicz, Paulina; Poreba, Marcin; Snipas, Scott J; Lin, S Jack; Kirchhofer, Daniel; Salvesen, Guy S; Drag, Marcin

Early Relapse of Follicular Lymphoma After Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Defines Patients at High Risk for Death: An Analysis From the National LymphoCare Study Journal of clinical oncology, 2015, ISSN: 0732-183X

Casulo, Carla; Byrtek, Michelle; Dawson, Keith L; Zhou, Xiaolei; Farber, Charles M; Flowers, Christopher R; Hainsworth, John D; Maurer, Matthew J; Cerhan, James R; Link, Brian K; Zelenetz, Andrew D; Friedberg, Jonathan W

Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial Journal of clinical oncology, 2015, ISSN: 0732-183X

Sandmann, Thomas; Bourgon, Richard; Garcia, Josep; Li, Congfen; Cloughesy, Timothy; Chinot, Olivier L; Wick, Wolfgang; Nishikawa, Ryo; Mason, Warren; Henriksson, Roger; Saran, Frank; Lai, Albert; Moore, Nicola; Kharbanda, Samir; Peale, Franklin; Hegde, Priti; Abrey, Lauren E; Phillips, Heidi S; Bais, Carlos

Outcomes of transformed follicular lymphoma in the modern era: a report from the National LymphoCare Study (NLCS) Blood, 2015, ISSN: 0006-4971

Wagner-Johnston, Nina D; Link, Brian K; Byrtek, Michelle; Dawson, Keith L; Hainsworth, John; Flowers, Christopher R; Friedberg, Jonathan W; Bartlett, Nancy L

Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress PloS one, 2015, ISSN: 1932-6203

D'Osualdo, Andrea; Anania, Veronica G; Yu, Kebing; Lill, Jennie R; Kaufman, Randal J; Matsuzawa, Shu-Ichi; Reed, John C

Deep sequencing-guided design of a high affinity dual-specific antibody to target two angiogenic factors in neovascular age-related macular degeneration Journal of biological chemistry, 2015, ISSN: 0021-9258

Koenig, Patrick; Lee, Chingwei V; Sanowar, Sarah; Wu, Ping; Stinson, Jeremy; Harris, Seth F; Fuh, Germaine

SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML Science signaling, 2015,

Fasci, Domenico; Anania, Veronica G; Lill, Jennie R; Salvesen, Guy S

Synthetic protein lipidation Current opinion in chemical biology, 2015, ISSN: 1367-5931

Hannoush, Rami N

Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women British journal of clinical pharmacology, 2015, ISSN: 0306-5251

Pillai, Venkateswaran C; Han, Kelong; Beigi, Richard H; Hankins, Gary D; Clark, Shannon; Hebert, Mary F; Easterling, Thomas R; Zajicek, Anne; Ren, Zhaoxia; Caritis, Steve N; Venkataramanan, Raman

MEK inhibitors beyond monotherapy: current and future development Current opinion in pharmacology, 2015, ISSN: 1471-4892

E Templeton, Ian; Musib, Luna

Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors Journal of Medicinal Chemistry, 2015,

Crawford, James J.; Lee, Wendy; Aliagas, Ignacio; Mathieu, Simon; Hoeflich, Klaus P.; Zhou, Wei; Wang, Weiru; Rouge, Lionel; Murray, Lesley; La, Hank; Liu, Ning; Fan, Peter W.; Cheong, Jonathan; Heise, Christopher E.; Ramaswamy, Sreemathy; Mintzer, Robert; Liu, Yanzhou; Chao, Qi; Rudolph, Joachim

Reproducibility: changing the policies and culture of cell line authentication Nature methods, 2015, ISSN: 1548-7091

Freedman, Leonard P; Gibson, Mark C; Ethier, Stephen P; Soule, Howard R; Neve, Richard M; Reid, Yvonne A

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies Journal of clinical pharmacology, 2015, ISSN: 0091-2700

Liu, Lichuan; Bello, Akintunde; Dresser, Mark J; Heald, Donald; Komjathy, Steven Ferenc; O'Mara, Edward; Rogge, Mark; Stoch, S Aubrey; Robertson, Sarah M

Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology Toxicological sciences, 2015, ISSN: 1096-0929

Kaplan, Barbara L F; Li, Jinze; LaPres, John J; Pruett, Stephen B; Karmaus, Peer W F

Clinical Pharmacology, creating current and future success in Drug Development Journal of clinical pharmacology, 2015, ISSN: 0091-2700

Rogge, Mark C; Dresser, Mark; Fossler, Michael; Heald, Donald; Stoch, S Aubrey; Vanevski, Konstantina M; Bello, Akintunde

Cancer immunotherapy. Neo approaches to cancer vaccines Science, 2015, ISSN: 0036-8075

Delamarre, Lélia; Mellman, Ira; Yadav, Mahesh

Neo approaches to cancer vaccines Science, 2015, ISSN: 0036-8075

Delamarre, Lelia; Mellman, Ira; Yadav, Mahesh

Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies Science translational medicine, 2015, ISSN: 1946-6234

Sun, Liping L; Ellerman, Diego; Mathieu, Mary; Hristopoulos, Maria; Chen, Xiaocheng; Li, Yijin; Yan, Xiaojie; Clark, Robyn; Reyes, Arthur; Stefanich, Eric; Mai, Elaine; Young, Judy; Johnson, Clarissa; Huseni, Mahrukh; Wang, Xinhua; Chen, Yvonne; Wang, Peiyin; Wang, Hong; Dybdal, Noel; Chu, Yu-Waye; Chiorazzi, Nicholas; Scheer, Justin M; Junttila, Teemu; Totpal, Klara; Dennis, Mark S; Ebens, Allen J

Translational value of mouse models in oncology drug development Nature medicine, 2015, ISSN: 1078-8956

Gould, Stephen E; Junttila, Melissa R; de Sauvage, Frederic J

Interactions Between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency In Aqueous Multi-Dose Formulations Pharmaceutical research, 2015, ISSN: 0724-8741

Heljo, P; Ross, A; Zarraga, I E; Pappenberger, A; Mahler, H-C

A resource for cell line authentication, annotation and quality control Nature, 2015, ISSN: 0028-0836

Yu, Mamie; Selvaraj, Suresh K; Liang-Chu, May M Y; Aghajani, Sahar; Busse, Matthew; Yuan, Jean; Lee, Genee; Peale, Franklin; Klijn, Christiaan; Bourgon, Richard; Kaminker, Joshua S; Neve, Richard M

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits PloS one, 2015, ISSN: 1932-6203

Diogo, Dorothée; Bastarache, Lisa; Liao, Katherine P; Graham, Robert R; Fulton, Robert S; Greenberg, Jeffrey D; Eyre, Steve; Bowes, John; Cui, Jing; Lee, Annette; Pappas, Dimitrios A; Kremer, Joel M; Barton, Anne; Coenen, Marieke J H; Franke, Barbara; Kiemeney, Lambertus A; Mariette, Xavier; Richard-Miceli, Corrine; Canhão, Helena; Fonseca, João E; de Vries, Niek; Tak, Paul P; Crusius, J Bart A; Nurmohamed, Michael T; Kurreeman, Fina; Mikuls, Ted R; Okada, Yukinori; Stahl, Eli A; Larson, David E; Deluca, Tracie L; O'Laughlin, Michelle; Fronick, Catrina C; Fulton, Lucinda L; Kosoy, Roman; Ransom, Michael; Bhangale, Tushar R; Ortmann, Ward; Cagan, Andrew; Gainer, Vivian; Karlson, Elizabeth W; Kohane, Isaac; Murphy, Shawn N; Martin, Javier; Zhernakova, Alexandra; Klareskog, Lars; Padyukov, Leonid; Worthington, Jane; Mardis, Elaine R; Seldin, Michael F; Gregersen, Peter K; Behrens, Timothy; Raychaudhuri, Soumya; Denny, Joshua C; Plenge, Robert M

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas PloS one, 2015, ISSN: 1932-6203

Schmitz, Katja; Koeppen, Hartmut; Binot, Elke; Fassunke, Jana; Künstlinger, Helen; Ihle, Michaela A; Heydt, Carina; Wardelmann, Eva; Büttner, Reinhard; Merkelbach-Bruse, Sabine; Rüschoff, Josef; Schildhaus, Hans-Ulrich

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo Journal of medicinal chemistry, 2015, ISSN: 0022-2623

Burch, Jason D; Barrett, Kathy; Chen, Yuan; DeVoss, Jason; Eigenbrot, Charles; Goldsmith, Richard; Ismaili, M Hicham A; Lau, Kevin; Lin, Zhonghua; Ortwine, Daniel F; Zarrin, Ali A; McEwan, Paul A; Barker, John J; Ellebrandt, Claire; Kordt, Daniel; Stein, Daniel B; Wang, Xiaolu; Chen, Yong; Hu, Baihua; Xu, Xiaofeng; Yuen, Po-Wai; Zhang, Yamin; Pei, Zhonghua

Baculovirus Display for Discovery of Low-Affinity Extracellular Receptor-ligand Interactions using Protein Microarrays Analytical biochemistry, 2015, ISSN: 0003-2697

Tom, Irene; Estevez, Alberto; Bowman, Krista; Gonzalez, Lino C

Regulation of the oncoprotein Smoothened by small molecules Nature chemical biology, 2015, ISSN: 1552-4450

Sharpe, Hayley J; Wang, Weiru; Hannoush, Rami N; de Sauvage, Frederic J

GPU-Accelerated Compartmental Modeling Analysis of DCE-MRI Data from Glioblastoma Patients Treated with Bevacizumab PloS one, 2015, ISSN: 1932-6203

Hsu, Yu-Han H; Huang, Ziyin; Ferl, Gregory Z; Ng, Chee M

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy Science translational medicine, 2015, ISSN: 1946-6234

Leverson, Joel D; Phillips, Darren C; Mitten, Michael J; Boghaert, Erwin R; Diaz, Dolores; Tahir, Stephen K; Belmont, Lisa D; Nimmer, Paul; Xiao, Yu; Ma, Xiaoju Max; Lowes, Kym N; Kovar, Peter; Chen, Jun; Jin, Sha; Smith, Morey; Xue, John; Zhang, Haichao; Oleksijew, Anatol; Magoc, Terrance J; Vaidya, Kedar S; Albert, Daniel H; Tarrant, Jacqueline M; La, Nghi; Wang, Le; Tao, Zhi-Fu; Wendt, Michael D; Sampath, Deepak; Rosenberg, Saul H; Tse, Chris; S Huang, David C; Fairbrother, Wayne J; Elmore, Steven W; Souers, Andrew J

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility Nature, 2015, ISSN: 0028-0836

Vitorino, Philip; Yeung, Stacey; Crow, Ailey; Bakke, Jesse; Smyczek, Tanya; West, Kristina; McNamara, Erin; Eastham-Anderson, Jeffrey; Gould, Stephen; Harris, Seth F; Ndubaku, Chudi; Ye, Weilan

Antibody Positron Emission Tomography Imaging in Anticancer Drug Development Journal of clinical oncology, 2015, ISSN: 0732-183X

Lamberts, Laetitia E; Williams, Simon P; Terwisscha van Scheltinga, Anton G T; Lub-de Hooge, Marjolijn N; Schröder, Carolien P; Gietema, Jourik A; Brouwers, Adrienne H; de Vries, Elisabeth G E

Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway Pharmaceutical research, 2015, ISSN: 0724-8741

Saggu, Miguel; Liu, Jun; Patel, Ankit

Obinutuzumab (G) plus fludarabine/cyclophosphamide (G-FC) or bendamustine (G-B) in the initial therapy of CLL patients: the phase 1b GALTON trial Blood, 2015, ISSN: 0006-4971

Brown, Jennifer R; O'Brien, Susan; Kingsley, C Daniel; Eradat, Herbert; Pagel, John M; Lymp, James; Hirata, Jamie; Kipps, Thomas J

Development of orthogonally protected hypusine for solid-phase Peptide synthesis Journal of organic chemistry, 2015, ISSN: 0022-3263

Song, Aimin; Tom, Jeffrey; Yu, Zhiyong; Pham, Victoria; Tan, Dajin; Zhang, Dengxiong; Fang, Guoyong; Yu, Tao; Deshayes, Kurt

Genomic analysis of smoothened inhibitor resistance in Basal cell carcinoma Cancer cell, 2015, ISSN: 1535-6108

Sharpe, Hayley J; Pau, Gregoire; Dijkgraaf, Gerrit J; Basset-Seguin, Nicole; Modrusan, Zora; Januario, Thomas; Tsui, Vickie; Durham, Alison B; Dlugosz, Andrzej A; Haverty, Peter M; Bourgon, Richard; Tang, Jean Y; Sarin, Kavita Y; Dirix, Luc; Fisher, David C; Rudin, Charles M; Sofen, Howard; Migden, Michael R; Yauch, Robert L; de Sauvage, Frederic J

Structural Analysis of Bacterial ABC Transporter Inhibition by an Antibody Fragment Structure, 2015, ISSN: 0969-2126

Ahuja, Shivani; Rougé, Lionel; Swem, Danielle L; Sudhamsu, Jawahar; Wu, Ping; Russell, Stephen J; Alexander, Mary Kate; Tam, Christine; Nishiyama, Mireille; Starovasnik, Melissa A; Koth, Christopher M

Human Biosample Authentication Using the High-Throughput, Cost-Effective SNPtraceTM System PloS one, 2015, ISSN: 1932-6203

Liang-Chu, May M Y; Yu, Mamie; Haverty, Peter M; Koeman, Julie; Ziegle, Janet; Lee, Marie; Bourgon, Richard; Neve, Richard M

Challenges and considerations for development of therapeutic proteins in pediatric patients Journal of clinical pharmacology, 2015, ISSN: 0091-2700

Zhang, Yi; Wei, Xiaohui; Bajaj, Gaurav; Barrett, Jeffrey S; Meibohm, Bernd; Joshi, Amita; Gupta, Manish

Feasibility and Cardiac Safety of Trastuzumab Emtansine After Anthracycline-Based Chemotherapy As (neo)Adjuvant Therapy for Human Epidermal Growth Factor Receptor 2-Positive Early-Stage Breast Cancer Journal of clinical oncology, 2015, ISSN: 0732-183X

Krop, Ian E; Suter, Thomas M; Dang, Chau T; Dirix, Luc; Romieu, Gilles; Zamagni, Claudio; Citron, Marc L; Campone, Mario; Xu, Na; Smitt, Melanie; Gianni, Luca

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells Nature, 2015, ISSN: 0028-0836

Rutz, Sascha; Kayagaki, Nobuhiko; Phung, Qui T; Eidenschenk, Celine; Noubade, Rajkumar; Wang, Xiaoting; Lesch, Justin; Lu, Rongze; Newton, Kim; Huang, Oscar W; Cochran, Andrea G; Vasser, Mark; Fauber, Benjamin P; DeVoss, Jason; Webster, Joshua; Diehl, Lauri; Modrusan, Zora; Kirkpatrick, Donald S; Lill, Jennie R; Ouyang, Wenjun; Dixit, Vishva M

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer New England Journal of Medicine, 2015,

Swain, Sandra M.; Baselga, José; Kim, Sung-Bae; Ro, Jungsil; Semiglazov, Vladimir; Campone, Mario; Ciruelos, Eva; Ferrero, Jean-Marc; Schneeweiss, Andreas; Heeson, Sarah; Clark, Emma; Ross, Graham; Benyunes, Mark C.; Cortés, Javier

Hepatic immune regulation by stromal cells Current Opinion in Immunology, 2015, ISSN: 0952-7915

Schildberg, Frank A; Sharpe, Arlene H; Turley, Shannon J

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection Immunity, 2015, ISSN: 1074-7613

Muñoz, Melba; Eidenschenk, Celine; Ota, Naruhisa; Wong, Kit; Lohmann, Uwe; Kühl, Anja A; Wang, Xiaoting; Manzanillo, Paolo; Li, Yun; Rutz, Sascha; Zheng, Yan; Diehl, Lauri; Kayagaki, Nobuhiko; van Lookeren-Campagne, Menno; Liesenfeld, Oliver; Heimesaat, Markus; Ouyang, Wenjun

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung Science Translational Medicine, 2015, ISSN: 1946-6234

R. N. Fuji; M. Flagella; M. Baca; M. A. S. Baptista; J. Brodbeck; B. K. Chan; B. K. Fiske; L. Honigberg; A. M. Jubb; P. Katavolos; D. W. Lee; S.-C. Lewin-Koh; T. Lin; X. Liu; S. Liu; J. P. Lyssikatos; J. O’Mahony; M. Reichelt; M. Roose-Girma; Z. Sheng; T. Sherer; A. Smith; M. Solon; Z. K. Sweeney; J. Tarrant; A. Urkowitz; S. Warming; M. Yaylaoglu; S. Zhang; H. Zhu; A. A. Estrada; R. J. Watts,

Targeting the extrinsic apoptotic pathway in cancer: Lessons learned and future directions Journal of Clinical Investigation, 2015,

Ashkenazi, Avi

Orchestrating high-throughput genomic analysis with Bioconductor Nature methods, 2015, ISSN: 1548-7091

Huber, Wolfgang; Carey, Vincent J; Gentleman, Robert; Anders, Simon; Carlson, Marc; Carvalho, Benilton S; Bravo, Hector Corrada; Davis, Sean; Gatto, Laurent; Girke, Thomas; Gottardo, Raphael; Hahne, Florian; Hansen, Kasper D; Irizarry, Rafael A; Lawrence, Michael; Love, Michael I; MacDonald, James; Obenchain, Valerie; Oleś, Andrzej K; Pagès, Hervé; Reyes, Alejandro; Shannon, Paul; Smyth, Gordon K; Tenenbaum, Dan; Waldron, Levi; Morgan, Martin

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10 Proceedings of the National Academy of Sciences, 2015, ISSN: 0027-8424

Fu, Chunmei; Liang, Xinjun; Cui, Weiguo; Ober-Blöbaum, Julia L; Vazzana, Joseph; Shrikant, Protul A; Lee, Kelvin P; Clausen, Björn E; Mellman, Ira; Jiang, Aimin

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria Nature cell biology, 2015, ISSN: 1465-7392

Cunningham, Christian N; Baughman, Joshua M; Phu, Lilian; Tea, Joy S; Yu, Christine; Coons, Mary; Kirkpatrick, Donald S; Bingol, Baris; Corn, Jacob E

Systematic Mapping of WNT-Frizzled Interactions Reveals Functional Selectivity by Distinct WNT-Frizzled Pairs Journal of biological chemistry, 2015, ISSN: 0021-9258

Dijksterhuis, Jacomijn Petronella; Baljinnyam, Bolormaa; Stanger, Karen; Sercan, Hakki Ogun; Ji, Yun; Andres, Osler; Rubin, Jeffrey S; Hannoush, Rami N; Schulte, Gunnar

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2 Journal of Medicinal Chemistry, 2015,

Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B.

Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior Proceedings of the National Academy of Sciences, 2015, ISSN: 0027-8424

Yamazaki, Maya; Le Pichon, Claire E; Jackson, Alexander C; Cerpas, Manuel; Sakimura, Kenji; Scearce-Levie, Kimberly; Nicoll, Roger A

Inhibitors of p21-Activated Kinases (PAKs) Journal of Medicinal Chemistry, 2015,

Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Weiru Wang

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Sharma, Vikas K; Patapoff, Thomas W; Kabakoff, Bruce; Pai, Satyan; Hilario, Eric; Zhang, Boyan; Li, Charlene; Borisov, Oleg; Kelley, Robert F; Chorny, Ilya; Zhou, Joe Z; Dill, Ken A; Swartz, Trevor E

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase Toxicological sciences, 2014, ISSN: 1096-0929

Zabka, T S; Singh, J T; Dhawan, P; Liederer, B M; Oeh, J; Kauss, M A; Xiao, Y; Zak, M; Lin, T; McCray, B; La, N; Beyer, J; Farman, C; Uppal, H; Dragovich, P S; O'Brien, T; Sampath, D; Misner, D L

A comprehensive transcriptional portrait of human cancer cell lines Nature biotechnology, 2014, ISSN: 1087-0156

Klijn, Christiaan; Durinck, Steffen; Stawiski, Eric W; Haverty, Peter M; Jiang, Zhaoshi; Liu, Hanbin; Degenhardt, Jeremiah; Mayba, Oleg; Gnad, Florian; Liu, Jinfeng; Pau, Gregoire; Reeder, Jens; Cao, Yi; Mukhyala, Kiran; Selvaraj, Suresh K; Yu, Mamie; Zynda, Gregory J; Brauer, Matthew J; Wu, Thomas D; Gentleman, Robert C; Manning, Gerard; Yauch, Robert L; Bourgon, Richard; Stokoe, David; Modrusan, Zora; Neve, Richard M; de Sauvage, Frederic J; Settleman, Jeffrey; Seshagiri, Somasekar; Zhang, Zemin

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors Journal of Medicinal Chemistry, 2014,

Cervi, Giovanni; Magnaghi, Paola; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Borghi, Daniela; Caruso, Michele; Cirla, Alessandra; Cozzi, Liviana; Felder, Eduard; Galvani, Arturo; Gasparri, Fabio; Lomolino, Antonio; Magnuson, Steven; Malgesini, Beatrice; Motto, Ilaria; Pasi, Maurizio; Rizzi, Simona; Salom, Barbara; Sorrentino, Graziella; Troiani, Sonia; Valsasina, Barbara; O'Brien, Thomas; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys Pharmaceutical research, 2014, ISSN: 0724-8741

Lu, Dan; Jin, Jin Yan; Girish, Sandhya; Agarwal, Priya; Li, Dongwei; Prabhu, Saileta; Dere, Randall C; Saad, Ola M; Nazzal, Denise; Koppada, Neelima; Ramanujan, Saroja; Ng, Chee M

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates Pharmaceutical research, 2014, ISSN: 0724-8741

Sukumaran, Siddharth; Gadkar, Kapil; Zhang, Crystal; Bhakta, Sunil; Liu, Luna; Xu, Keyang; Raab, Helga; Yu, Shang-Fan; Mai, Elaine; Fourie-O'Donohue, Aimee; Kozak, Katherine R; Ramanujan, Saroja; Junutula, Jagath R; Lin, Kedan

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates Pharmaceutical research, 2014, ISSN: 0724-8741

Kamath, Amrita V; Iyer, Suhasini

Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams. Journal of Organic Chemistry, 2014,

Fauber, B. P.; Clagg, K.; Gibbons, P.; René, O.

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer Nature, 2014, ISSN: 0028-0836

Powles, Thomas; Eder, Joseph Paul; Fine, Gregg D; Braiteh, Fadi S; Loriot, Yohann; Cruz, Cristina; Bellmunt, Joaquim; Burris, Howard A; Petrylak, Daniel P; Teng, Siew-Leng; Shen, Xiaodong; Boyd, Zachary; Hegde, Priti S; Chen, Daniel S; Vogelzang, Nicholas J

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature, 2014, ISSN: 0028-0836

Herbst, Roy S; Soria, Jean-Charles; Kowanetz, Marcin; Fine, Gregg D; Hamid, Omid; Gordon, Michael S; Sosman, Jeffery A; McDermott, David F; Powderly, John D; Gettinger, Scott N; Kohrt, Holbrook E K; Horn, Leora; Lawrence, Donald P; Rost, Sandra; Leabman, Maya; Xiao, Yuanyuan; Mokatrin, Ahmad; Koeppen, Hartmut; Hegde, Priti S; Mellman, Ira; Chen, Daniel S; Hodi, F Stephen

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing Nature, 2014, ISSN: 0028-0836

Yadav, Mahesh; Jhunjhunwala, Suchit; Phung, Qui T; Lupardus, Patrick; Tanguay, Joshua; Bumbaca, Stephanie; Franci, Christian; Cheung, Tommy K; Fritsche, Jens; Weinschenk, Toni; Modrusan, Zora; Mellman, Ira; Lill, Jennie R; Delamarre, Lélia

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function Cancer cell, 2014, ISSN: 1535-6108

Johnston, Robert J; Comps-Agrar, Laetitia; Hackney, Jason; Yu, Xin; Huseni, Mahrukh; Yang, Yagai; Park, Summer; Javinal, Vincent; Chiu, Henry; Irving, Bryan; Eaton, Dan L; Grogan, Jane L

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death Nature medicine, 2014, ISSN: 1078-8956

Wetzel-Smith, Monica K; Hunkapiller, Julie; Bhangale, Tushar R; Srinivasan, Karpagam; Maloney, Janice A; Atwal, Jasvinder K; Sa, Susan M; B Yaylaoglu, Murat; Foreman, Oded; Ortmann, Ward; Rathore, Nisha; Hansen, David V; Tessier-Lavigne, Marc; Mayeux, Richard; Pericak-Vance, Margaret; Haines, Jonathan; Farrer, Lindsay A; Schellenberg, Gerard D; Goate, Alison; Behrens, Timothy W; Cruchaga, Carlos; Watts, Ryan J; Graham, Robert R

8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors Journal of Medicinal Chemistry, 2014,

Thomas, Allen A.; Hunt, Kevin W.; Newhouse, Brad; Watts, Ryan J.; Liu, Xingrong; Vigers, Guy; Smith, Darin; Rhodes, Susan P.; Brown, Karin D.; Otten, Jennifer N.; Burkard, Michael; Cox, April A.; Geck Do, Mary K.; Dutcher, Darrin; Rana, Sumeet; Delisle, Robert K.; Regal, Kelly; Wright, Albion D.; Groneberg, Robert; Liao, Jiangpeng; Scearce-Levie, Kimberly; Siu, Michael; Purkey, Hans E.; Lyssikatos, Joseph P.

The Blood-Brain Barrier's Gut Check Science translational medicine, 2014, ISSN: 1946-6234

Bien-Ly, Nga; Watts, Ryan J

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes Nature genetics, 2014, ISSN: 1061-4036

Durinck, Steffen; Stawiski, Eric W; Pavía-Jiménez, Andrea; Modrusan, Zora; Kapur, Payal; Jaiswal, Bijay S; Zhang, Na; Toffessi-Tcheuyap, Vanina; Nguyen, Thong T; Pahuja, Kanika Bajaj; Chen, Ying-Jiun; Saleem, Sadia; Chaudhuri, Subhra; Heldens, Sherry; Jackson, Marlena; Peña-Llopis, Samuel; Guillory, Joseph; Toy, Karen; Ha, Connie; Harris, Corissa J; Holloman, Eboni; Hill, Haley M; Stinson, Jeremy; Rivers, Celina Sanchez; Janakiraman, Vasantharajan; Wang, Weiru; Kinch, Lisa N; Grishin, Nick V; Haverty, Peter M; Chow, Bernard; Gehring, Julian S; Reeder, Jens; Pau, Gregoire; Wu, Thomas D; Margulis, Vitaly; Lotan, Yair; Sagalowsky, Arthur; Pedrosa, Ivan; de Sauvage, Frederic J; Brugarolas, James; Seshagiri, Somasekar

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18 Science, 2014, ISSN: 0036-8075

Zhang, Benyue; Chassaing, Benoit; Shi, Zhenda; Uchiyama, Robin; Zhang, Zhan; Denning, Timothy L; Crawford, Sue E; Pruijssers, Andrea J; Iskarpatyoti, Jason A; Estes, Mary K; Dermody, Terence S; Ouyang, Wenjun; Williams, Ifor R; Vijay-Kumar, Matam; Gewirtz, Andrew T

Dusp5 negatively regulates IL-33-mediated eosinophil survival and function EMBO journal, 2014, ISSN: 0261-4189

Holmes, Derek A; Yeh, Jung-Hua; Yan, Donghong; Xu, Min; Chan, Andrew C

TNFR1-activated NF-κB signal transduction: Regulation by the ubiquitin/proteasome system Current Opinion in Chemical Biology, 2014, ISSN: 1367-5931

Wertz, Ingrid E

Internal motions prime cIAP1 for rapid activation Nature structural & molecular biology, 2014, ISSN: 1545-9985

Phillips, Aaron H; Schoeffler, Allyn J; Matsui, Tsutomu; Weiss, Thomas M; Blankenship, John W; Zobel, Kerry; Giannetti, Anthony M; Dueber, Erin C; Fairbrother, Wayne J

HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme Developmental Cell, 2014, ISSN: 1534-5807

Osterwalder, Marco; Speziale, Dario; Shoukry, Malak; Mohan, Rajiv; Ivanek, Robert; Kohler, Manuel; Beisel, Christian; Wen, Xiaohui; Scales, Suzie J.; Christoffels, Vincent M.; Visel, Axel; Lopez-Rios, Javier; Zeller, Rolf; Lopez-Rios, J

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Hanan, Emily J; Eigenbrot, Charles; Bryan, Marian C; Burdick, Daniel J; Chan, Bryan K; Chen, Yuan; Dotson, Jennafer; Heald, Robert A; Jackson, Philip S; La, Hank; Lainchbury, Michael D; Malek, Shiva; Purkey, Hans E; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M; Sideris, Steve; Tam, Christine; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yin, Jianping; Yu, Christine; Zilberleyb, Inna; Heffron, Timothy P

Ubiquitination in disease pathogenesis and treatment Nature medicine, 2014, ISSN: 1078-8956

Popovic, Doris; Vucic, Domagoj; Dikic, Ivan

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates Science translational medicine, 2014, ISSN: 1946-6234

Yu, Y Joy; Atwal, Jasvinder K; Zhang, Yin; Tong, Raymond K; Wildsmith, Kristin R; Tan, Christine; Bien-Ly, Nga; Hersom, Maria; Maloney, Janice A; Meilandt, William J; Bumbaca, Daniela; Gadkar, Kapil; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Ernst, James A; Scearce-Levie, Kimberly; Couch, Jessica A; Dennis, Mark S; Watts, Ryan J

Inhibiting the Deubiquitinating Enzymes (DUBs) Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Ndubaku, Chudi; Tsui, Vickie

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production Nature immunology, 2014, ISSN: 1529-2908

Simpson, Laura J; Patel, Sana; Bhakta, Nirav R; Choy, David F; Brightbill, Hans D; Ren, Xin; Wang, Yanli; Pua, Heather H; Baumjohann, Dirk; Montoya, Misty M; Panduro, Marisella; Remedios, Kelly A; Huang, Xiaozhu; Fahy, John V; Arron, Joseph R; Woodruff, Prescott G; Ansel, K Mark

Preclinical efficacy of MEK inhibition in Nras mutant acute myeloid leukemia Blood, 2014, ISSN: 0006-4971

Burgess, Michael R; Hwang, Eugene; Firestone, Ari J; Huang, Tannie; Xu, Jin; Zuber, Johannes; Bohin, Natacha; Wen, Tiffany; Kogan, Scott C; Haigis, Kevin M; Sampath, Deepak; Lowe, Scott; Shannon, Kevin; Li, Qing

Depletion of the central metabolite NAD leads to oncosis mediated cell death Journal of biological chemistry, 2014, ISSN: 0021-9258

Del Nagro, Christopher; Xiao, Yang; Rangell, Linda; Reichelt, Mike; O'Brien, Thomas

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture Nature immunology, 2014, ISSN: 1529-2908

Astarita, Jillian L; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C; Peck, James R; Nieves-Bonilla, Janice M; Song, Kai; Kondo, Yuji; Woodruff, Matthew C; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M; Carroll, Michael C; Mooney, David J; Xia, Lijun; Turley, Shannon J

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Patel, Snahel; Cohen, Frederick; Dean, Brian J; De La Torre, Kelly; Deshmukh, Gauri; Estrada, Anthony A; Ghosh, Arundhati Sengupta; Gibbons, Paul; Gustafson, Amy; Huestis, Malcolm P; Le Pichon, Claire E; Lin, Han; Liu, Wendy; Liu, Xingrong; Liu, Yichin; Ly, Cuong Q; Lyssikatos, Joseph P; Ma, Changyou; Scearce-Levie, Kimberly; Shin, Young G; Solanoy, Hilda; Stark, Kimberly L; Wang, Jian; Wang, Bei; Zhao, Xianrui; Lewcock, Joseph W; Siu, Michael

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors PloS one, 2014, ISSN: 1932-6203

Wang, Weiru; Elkins, Kristi; Oh, Angela; Ho, Yen-Ching; Wu, Jiansheng; Li, Hong; Xiao, Yang; Kwong, Mandy; Coons, Mary; Brillantes, Bobby; Cheng, Eric; Crocker, Lisa; Dragovich, Peter S; Sampath, Deepak; Zheng, Xiaozhang; Bair, Kenneth W; O'Brien, Thomas; Belmont, Lisa D

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Wang, Shan-Shan; Gu, Yi-Feng; Wolff, Nicholas; Stefanius, Karoliina; Christie, Alana; Dey, Anwesha; Hammer, Robert E; Xie, Xian-Jin; Rakheja, Dinesh; Pedrosa, Ivan; Carroll, Thomas; McKay, Renée M; Kapur, Payal; Brugarolas, James

Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma New England Journal of Medicine, 2014, ISSN: 0028-4793

Larkin, James; Ascierto, Paolo A; Dréno, Brigitte; Atkinson, Victoria; Liszkay, Gabriella; Maio, Michele; Mandalà, Mario; Demidov, Lev; Stroyakovskiy, Daniil; Thomas, Luc; Merino, Luis de la Cruz; Dutriaux, Caroline; Garbe, Claus; Sovak, Mika A; Chang, Ilsung; Choong, Nicholas; Hack, Stephen P; McArthur, Grant A; Ribas, Antoni

Molecular Mechanisms of Alzheimer's Disease Protection by the A673T Allele of Amyloid Precursor Protein Journal of Biological Chemistry, 2014, ISSN: 0021-9258

Maloney, Janice A; Bainbridge, Travis; Gustafson, Amy; Zhang, Shuo; Kyauk, Roxanne; Steiner, Pascal; van der Brug, Marcel; Liu, Yichin; Ernst, James A; Watts, Ryan J; Atwal, Jasvinder K

Complement Inhibition in Cynomolgus Monkey by Anti-Factor D Antigen-Binding Fragment for the Treatment of an Advanced Form of Dry Age-Related Macular Degeneration Journal of Pharmacology and Experimental Therapeutics, 2014, ISSN: 0022-3565

Loyet, Kelly M; Good, Jeremy; Davancaze, Teresa; Sturgeon, Lizette; Wang, Xiangdan; Yang, Jihong; Le, Kha; Wong, Maureen; Hass, Philip E; van Lookeren Campagne, Menno; Haughney, Peter; Morimoto, Alyssa; Damico-Beyer, Lisa A; DeForge, Laura E

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Chen, Ruihuan; Nishimura, Merry C; Kharbanda, Samir; Peale, Frank; Deng, Yuzhong; Daemen, Anneleen; Forrest, William F; Kwong, Mandy; Hedehus, Maj; Hatzivassiliou, Georgia; Friedman, Lori S; Phillips, Heidi S

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiota Proceedings of the National Academy of Sciences, 2014, ISSN: 1091-6490

Vincent Feng-Sheng Shih;Jennifer Cox;Noelyn M. Kljavin;Hart S. Dengler;Mike Reichelt;Pawan Kumar;Linda Rangell;Jay K. Kolls;Lauri Diehl;Wenjun Ouyang;Nico Ghilardi;

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X Journal of Experimental Medicine, 2014, ISSN: 0022-1007

Naik, Edwina; Webster, Joshua D; DeVoss, Jason; Liu, Jinfeng; Suriben, Rowena; Dixit, Vishva M

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections Journal of Experimental Medicine, 2014, ISSN: 0022-1007

Conti, Heather R.; Peterson, Alanna C.; Brane, Lucas; Huppler, Anna R.; Hernández-Santos, Nydiaris; Whibley, Natasha; Garg, Abhishek V.; Simpson-Abelson, Michelle R.; Gibson, Gregory A.; Mamo, Anna J.; Osborne, Lisa C.; Bishu, Shrinivas;Ghilardi, Nico; Siebenlist, Ulrich; Watkins, Simon C.; Artis, David; McGeachy , Mandy J.; Gaffen, Sarah L.

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering Journal of Medicinal Chemistry, 2014,

Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O’Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; D. Leipold, Douglas; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Lewis Phillips, Gail D.; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R.

Shining LIGHT on Functional Promiscuity in the TNF and TNFR Superfamilies Structure, 2014, ISSN: 0969-2126

Whalen, Daniel M; Hymowitz, Sarah G

Recombinant antibody color resulting from advanced glycation end product modifications Analytical chemistry, 2014, ISSN: 0003-2700

Butko, Margaret; Pallat, Hilary; Cordoba, Armando; Yu, X Christopher

Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration Pharmaceutical Research, 2014, ISSN: 0724-8741

Singh, Shubhadra N.; Yadav, Sandeep; Shire, Steven J.; Kalonia, Devendra S.; Kalonia, D S

Targeting IgE production in mice and humans Current opinion in immunology, 2014, ISSN: 0952-7915

Wu, Lawren C; Scheerens, Heleen

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling Cancer Cell, 2014, ISSN: 1535-6108

Haling, Jacob R; Sudhamsu, Jawahar; Yen, Ivana; Sideris, Steve; Sandoval, Wendy; Phung, Wilson; Bravo, Brandon J; Giannetti, Anthony M; Peck, Ariana; Masselot, Alexandre; Morales, Tony; Smith, Darin; Brandhuber, Barbara J; Hymowitz, Sarah G; Malek, Shiva

Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease Structure, 2014, ISSN: 0969-2126

Lin, S Jack; Dong, Ken C; Eigenbrot, Charles; van Lookeren Campagne, Menno; Kirchhofer, Daniel

Understanding the effect of the HCV polymerase inhibitor mericitabine on early viral kinetics in the phase 2 JUMP-C and PROPEL studies British Journal of Clinical Pharmacology, 2014, ISSN: 03065251

Chen, Ya-Chi; Bernaards, Coen; Kulkarni, Rohit; Moreira, Sebastian; Zhu, Yonghong; Chan, Anna; Badman, Ethan; Ackrill, Andrew; Thommes, James; Smith, Patrick F.; Chen, Y.-C.

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes Nature, 2014, ISSN: 0028-0836

Wang, Xiaoting; Ota, Naruhisa; Manzanillo, Paolo; Kates, Lance; Zavala-Solorio, Jose; Eidenschenk, Celine; Zhang, Juan; Lesch, Justin; Lee, Wyne P; Ross, Jed; Diehl, Lauri; van Bruggen, Nicholas; Kolumam, Ganesh; Ouyang, Wenjun

Rational Use of Plasma Protein and Tissue Binding Data in Drug Design Journal of Medicinal Chemistry, 2014, ISSN: 0022-2623

Liu, Xingrong; Wright, Matthew; Hop, Cornelis E C A

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia Nature, 2014, ISSN: 0028-0836

Dail, Monique; Wong, Jason; Lawrence, Jessica; O'Connor, Daniel; Nakitandwe, Joy; Chen, Shann-Ching; Xu, Jin; Lee, Leslie B; Akagi, Keiko; Li, Qing; Aster, Jon C; Pear, Warren S; Downing, James R; Sampath, Deepak; Shannon, Kevin

Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity Blood, 2014, ISSN: 0006-4971

Lee-Chang, Catalina; Bodogai, Monica; Moritoh, Kanako; Olkhanud, Purevdorj B; Chan, Andrew C; Croft, Michael; Mattison, Julie A; Holst, Peter Johannes; Gress, Ronald E; Ferrucci, Luigi; Hakim, Fran; Biragyn, Arya

Human CD68 promoter directs GFP transgene expression in mouse myeloid cells, allowing analysis of monocyte to macrophage differentiation in vivo Blood, 2014, ISSN: 0006-4971

Iqbal, Asif J; McNeill, Eileen; Kapellos, Theodore S; Regan-Komito, Daniel; Norman, Sophie; Burd, Sarah; Smart, Nicola; Machemer, Daniel E W; Stylianou, Elena; McShane, Helen; Channon, Keith M; Chawla, Ajay; Greaves, David R

Evolutionary Divergence in the Catalytic Activity of the CAM-1, ROR1 and ROR2 Kinase Domains PLoS ONE, 2014, ISSN: 1932-6203

Bainbridge, Travis W; DeAlmeida, Venita I; Izrael-Tomasevic, Anita; Chalouni, Cécile; Pan, Borlan; Goldsmith, Joshua; Schoen, Alia P; Quiñones, Gabriel A; Kelly, Ryan; Lill, Jennie R; Sandoval, Wendy; Costa, Mike; Polakis, Paul; Arnott, David; Rubinfeld, Bonnee; Ernst, James A

Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: An Integrated Safety Analysis Journal of clinical oncology, 2014, ISSN: 0732-183X

Diéras, Véronique; Harbeck, Nadia; Budd, G Thomas; Greenson, Joel K; Guardino, Alice E; Samant, Meghna; Chernyukhin, Nataliya; Smitt, Melanie C; Krop, Ian E

Real-time immuno-polymerase chain reaction in a 384-well format: Detection of vascular endothelial growth factor and epidermal growth factor-like domain 7 Analytical Biochemistry, 2014, ISSN: 0003-2697

Zhang, Jianhuan; Vernes, Jean-Michel; Ni, Jennifer; Nelson, Christopher; Wong, Anne; Chen, Steven T.; Asundi, Aarati; Vandlen, Richard; Meng, Y. Gloria;

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis Science, 2014, ISSN: 0036-8075

Lu, Min; Lawrence, David A; Marsters, Scot; Acosta-Alvear, Diego; Kimmig, Philipp; Mendez, Aaron S; Paton, Adrienne W; Paton, James C; Walter, Peter; Ashkenazi, Avi

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium Development, 2014, ISSN: 0950-1991

Castillo, David; Seidel, Kerstin; Salcedo, Ernesto; Ahn, Christina; de Sauvage, Frederic J; Klein, Ophir D; Barlow, Linda A

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production Science translational medicine, 2014, ISSN: 1946-6234

Gauvreau, Gail M; Harris, Jeffrey M; Boulet, Louis-Philippe; Scheerens, Heleen; Fitzgerald, J Mark; Putnam, Wendy S; Cockcroft, Donald W; Davis, Beth E; Leigh, Richard; Zheng, Yanan; Dahlén, Barbro; Wang, Yehong; Maciuca, Romeo; Mayers, Irvin; Liao, X Charlene; Wu, Lawren C; Matthews, John G; O'Byrne, Paul M

Activity-Induced Nr4a1 Regulates Spine Density and Distribution Pattern of Excitatory Synapses in Pyramidal Neurons Neuron, 2014, ISSN: 0896-6273

Chen, Yelin; Wang, Yuanyuan; Ertürk, Ali; Kallop, Dara; Jiang, Zhiyu; Weimer, Robby M; Kaminker, Joshua; Sheng, Morgan

Designer proteins to trigger cell death Cell, 2014, ISSN: 0092-8674

Fairbrother, Wayne J; Ashkenazi, Avi;

From Cancer Genomics to Precision Oncology-Tissue's Still an Issue Cell, 2014, ISSN: 0092-8674

Cohen, Robert L; Settleman, Jeff;

Parallel Discovery of Alzheimer’s Therapeutics Science translational medicine, 2014, ISSN: 1946-6234

Lo, Andrew W; Lo, Andrew W; Ho, Carole; Cummings, Jayna; Kosik, Kenneth S; NLM

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer Nature, 2014, ISSN: 0028-0836

Ali, Khaled; Soond, Dalya R; Piñeiro, Roberto; Hagemann, Thorsten; Pearce, Wayne; Lim, Ee Lyn; Bouabe, Hicham; Scudamore, Cheryl L; Hancox, Timothy; Maecker, Heather; Friedman, Lori; Turner, Martin; Okkenhaug, Klaus; Vanhaesebroeck, Bart;

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Burch, Jason D; Lau, Kevin; Barker, John J; Brookfield, Fred; Chen, Yong; Chen, Yuan; Eigenbrot, Charles; Ellebrandt, Claire; Ismaili, M Hicham A; Johnson, Adam; Kordt, Daniel; MacKinnon, Colin H; McEwan, Paul A; Ortwine, Daniel F; Stein, Daniel B; Wang, Xiaolu; Winkler, Dirk; Yuen, Po-Wai; Zhang, Yamin; Zarrin, Ali A; Pei, Zhonghua

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia Blood, 2014, ISSN: 0006-4971

Weisser, Martin; Yeh, Ru-Fang; Duchateau-Nguyen, Guillemette; Palermo, Giuseppe; Nguyen, Tri Quang; Shi, Xiaoyan; Stinson, Susanna Y; Yu, Nancy; Dufour, Annika; Robak, Tadeusz; Salogub, Galina N; Dmoszynska, Anna; Solal-Celigny, Philippe; Warzocha, Krzysztof; Loscertales, Javier; Catalano, John; Larratt, Loree; Rossiev, Victor A; Bence-Bruckler, Isabelle; Geisler, Christian H; Montillo, Marco; Fischer, Kirsten; Fink, Anna-Maria; Hallek, Michael; Bloehdorn, Johannes; Busch, Raymonde; Benner, Axel; Döhner, Hartmut; Valente, Nancy; Wenger, Michael K; Stilgenbauer, Stephan; Dornan, David;

Pannexin-1 Is Blocked by Its C-Terminus through a Delocalized Non-Specific Interaction Surface PLoS ONE, 2014, ISSN: 1932-6203

Dourado, Michelle; Wong, Evera; Hackos, David H;

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas Cancer cell, 2014, ISSN: 1535-6108

Affara, Nesrine I; Ruffell, Brian; Medler, Terry R; Gunderson, Andrew J; Johansson, Magnus; Bornstein, Sophia; Bergsland, Emily; Steinhoff, Martin; Li, Yijin; Gong, Qian; Ma, Yan; Wiesen, Jane F; Wong, Melissa H; Kulesz-Martin, Molly; Irving, Bryan; Coussens, Lisa M;

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy Nature, 2014, ISSN: 0028-0836

Bingol, Baris; Tea, Joy S; Phu, Lilian; Reichelt, Mike; Bakalarski, Corey E; Song, Qinghua; Foreman, Oded; Kirkpatrick, Donald S; Sheng, Morgan; NLM

Mechanisms and Functions of Inflammasomes Cell, 2014, ISSN: 0092-8674

Lamkanfi, Mohamed; Lamkanfi, Mohamed; Dixit, Vishva M; NLM

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis Molecular Cell, 2014, ISSN: 1097-2765

Lu, Min; Marsters, Scot; Ye, Xiaofen; Luis, Elizabeth; Gonzalez, Lino; Ashkenazi, Avi;

Characterization of oxidative carbonylation on recombinant monoclonal antibodies Analytical chemistry, 2014, ISSN: 0003-2700

Yang, Yi; Yang, Yi; Stella, Cinzia; Wang, Weiru; Schöneich, Christian; Gennaro, Lynn; NLM

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides Nature Chemical Biology, 2014, ISSN: 1552-4450

Landgraf, Kyle E; Steffek, Micah; Quan, Clifford; Tom, Jeffrey; Yu, Christine; Santell, Lydia; Maun, Henry R; Eigenbrot, Charles; Lazarus, Robert A

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration Science signaling, 2014, ISSN: 1525-8882

Mooz, Juliane; Oberoi-Khanuja, Tripat Kaur; Harms, Gregory S; Wang, Weiru; Jaiswal, Bijay S; Seshagiri, Somasekar; Tikkanen, Ritva; Rajalingam, Krishnaraj

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription American journal of human genetics, 2014, ISSN: 0002-9297

Guthridge, Joel M; Guthridge, Joel M; Lu, Rufei; Sun, Harry; Sun, Celi; Wiley, Graham B; Dominguez, Nicolas; Macwana, Susan R; Lessard, Christopher J; Kim-Howard, Xana; Cobb, Beth L; Kaufman, Kenneth M; Kelly, Jennifer A; Langefeld, Carl D; Adler, Adam J; Harley, Isaac T W; Merrill, Joan T; Gilkeson, Gary S; Kamen, Diane L; Niewold, Timothy B; Brown, Elizabeth E; Edberg, Jeffery C; Petri, Michelle A; Ramsey-Goldman, Rosalind; Reveille, John D; Vilá, Luis M; Kimberly, Robert P; Freedman, Barry I; Stevens, Anne M; Boackle, Susan A; Criswell, Lindsey A; Vyse, Tim J; Behrens, Timothy W; Jacob, Chaim O; Alarcón-Riquelme, Marta E; Sivils, Kathy L; Choi, Jiyoung; Joo, Young Bin; Bang, So-Young; Lee, Hye-Soon; Bae, Sang-Cheol; Shen, Nan; Qian, Xiaoxia; Tsao, Betty P; Scofield, R Hal; Harley, John B; Webb, Carol F; Wakeland, Edward K; James, Judith A; Nath, Swapan K; Graham, Robert R; Gaffney, Patrick M; NLM

The Effects of a High-Fat Meal on Single-Dose Vemurafenib Pharmacokinetics Journal of Clinical Pharmacology, 2014, ISSN: 1552-4604

Ribas, Antoni; Zhang, Weijiang; Chang, Ilsung; Shirai, Keisuke; Ernstoff, Marc S.; Daud, Adil; Cowey, C. Lance; Daniels, Gregory; Seja, Elizabeth; O'Laco, Elizabeth; Glaspy, John A.; Chmielowski, Bartosz; Hill, Todd; Joe, Andrew K.; Grippo, Joseph F.

Characterization and stability study of polysorbate 20 in therapeutic monoclonal antibody formulation by multidimensional ultrahigh-performance liquid chromatography-charged aerosol detection-mass spectrometry Analytical chemistry, 2014, ISSN: 0003-2700

Li, Yi; Li, Yi; Hewitt, Daniel; Lentz, Yvonne K; Ji, Junyan A; Zhang, Taylor Y; Zhang, Kelly; NLM

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases Nature, 2014, ISSN: 0028-0836

Meunier, Etienne; Meunier, Etienne; Dick, Mathias S; Dreier, Roland F; Schürmann, Nura; Broz, Daniela Kenzelmann; Warming, Søren; Roose-Girma, Merone; Bumann, Dirk; Kayagaki, Nobuhiko; Takeda, Kiyoshi; Yamamoto, Masahiro; Broz, Petr; NLM

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity Nature, 2014, ISSN: 0028-0836

Noubade, Rajkumar; Wong, Kit; Ota, Naruhisa; Rutz, Sascha; Eidenschenk, Celine; Valdez, Patricia A; Ding, Jiabing; Peng, Ivan; Sebrell, Andrew; Caplazi, Patrick; Devoss, Jason; Soriano, Robert H; Sai, Tao; Lu, Rongze; Modrusan, Zora; Hackney, Jason; Ouyang, Wenjun; NLM

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection PLoS pathogens, 2014, ISSN: 1553-7366

Auerbach, Marcy R; Auerbach, Marcy R; Yan, Donghong; Vij, Rajesh; Hongo, Jo-Anne; Nakamura, Gerald; Vernes, Jean-Michel; Meng, Y Gloria; Lein, Samantha; Chan, Pamela; Ross, Jed; Carano, Richard; Deng, Rong; Lewin-Koh, Nicholas; Xu, Min; Feierbach, Becket; NLM

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2 Nature Structural & Molecular Biology, 2014, ISSN: 1545-9993

Wallweber, Heidi J A; Wallweber, Heidi J A; Tam, Christine; Franke, Yvonne; Starovasnik, Melissa A; Lupardus, Patrick J; NLM

Ubiquitin in inflammation: the right linkage makes all the difference Nature Structural & Molecular Biology, 2014, ISSN: 1545-9993

Corn, Jacob E; Vucic, Domagoj

In Search of Magic Bullets: The Golden Age of Immunotherapeutics Cell, 2014, ISSN: 0092-8674

O'Shea, John J; Kanno, Yuka; Chan, Andrew C

Characterization of in vitro Antibody-dependent Cell-mediated Cytotoxicity Activity of Therapeutic Antibodies - Impact of Effector Cells Journal of Immunological Methods, 2014, ISSN: 1872-7905

Chung S; Lin Y; Reed C; Ng C; Cheng CJ; Malavasi F; Yang J; Quarmby V; Song A

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling Nature, 2014, ISSN: 0028-0836

Nakamura, Norihiro; Lill, Jennie R; Phung, Qui; Jiang, Zhaoshi; Bakalarski, Corey; de Mazière, Ann; Klumperman, Judith; Schlatter, Megan; Delamarre, Lélia; Mellman, Ira

Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Crawford, Terry D; Crawford, Terry D; Ndubaku, Chudi O; Chen, Huifen; Boggs, Jason W; Bravo, Brandon J; Delatorre, Kelly; Giannetti, Anthony M; Gould, Stephen E; Harris, Seth F; Magnuson, Steven R; McNamara, Erin; Murray, Lesley J; Nonomiya, Jim; Sambrone, Amy; Schmidt, Stephen; Smyczek, Tanya; Stanley, Mark; Vitorino, Philip; Wang, Lan; West, Kristina; Wu, Ping; Ye, Weilan; NLM

Next Generation MUT-MAP, a High-Sensitivity High-Throughput Microfluidics Chip-Based Mutation Analysis Panel PloS one, 2014, ISSN: 1932-6203

Schleifman, Erica B; Tam, Rachel; Patel, Rajesh; Tsan, Alison; Sumiyoshi, Teiko; Fu, Ling; Desai, Rupal; Schoenbrunner, Nancy; Myers, Thomas W; Bauer, Keith; Smith, Edward; Raja, Rajiv

SERPINs shelter the endowed migrants in a hostile land EMBO Journal, 2014, ISSN: 0261-4189

Ye, Weilan

Multiplexed ion beam imaging of human breast tumors Nature Medicine, 2014, ISSN: 1078-8956

Angelo, Michael; Bendall, Sean C; Finck, Rachel; Hale, Matthew B; Hitzman, Chuck; Borowsky, Alexander D; Levenson, Richard M; Lowe, John B; Liu, Scot D; Zhao, Shuchun; Natkunam, Yasodha; Nolan, Garry P

Method for cellular imaging of palmitoylated proteins with clickable probes and proximity ligation applied to hedgehog, tubulin, and ras Journal of the American Chemical Society, 2014, ISSN: 0002-7863

Gao, Xinxin; Hannoush, Rami N

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4 + T cells Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Altin, John A.; Daley, Stephen R.; Howitt, Jason; Rickards, Helen J.; Batkin, Alison K.; Horikawa, Keisuke; Prasad, Simon J.; Nelms, Keats A.; Kumar, Sharad; Wu, Lawren C.; Tan, Seong-Seng; Cook, Matthew C.; Goodnow, Christopher C.

Is SIRT2 required for necroptosis? Nature, 2014, ISSN: 0028-0836

Newton, Kim; Hildebrand, Joanne M; Shen, Zhirong; Rodriguez, Diego; Alvarez-Diaz, Silvia; Petersen, Sean; Shah, Saumil; Dugger, Debra L; Huang, Chunzi; Auwerx, Johan; Vandenabeele, Peter; Green, Douglas R; Ashkenazi, Avi; Dixit, Vishva M; Kaiser, William J; Strasser, Andreas; Degterev, Alexei; Silke, John

Clinical Validation of a PCR Assay for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer: Retrospective Testing of Specimens from the EURTAC Trial PLoS ONE, 2014, ISSN: 1932-6203

Benlloch, Susana; Botero, Maria Luisa; Beltran-Alamillo, Jordi; Mayo, Clara; Gimenez-Capitán, Ana; de Aguirre, Itziar; Queralt, Cristina; Ramirez, Jose Luis; Cajal, Santiago Ramón Y; Klughammer, Barbara; Schlegel, Mariette; Bordogna, Walter; Chen, David; Zhang, Guili; Kovach, Barbara; Shieh, Felice; Palma, John F; Wu, Lin; Lawrence, H Jeffrey; Taron, Miquel

Activity of Protein Kinase RIPK3 Determines whether Cells Die by Necroptosis or Apoptosis Science, 2014, ISSN: 0036-8075

Newton, Kim; Dugger, Debra L; Wickliffe, Katherine E; Kapoor, Neeraj; Cristina de-Almagro, M; Vucic, Domagoj; Komuves, Laszlo; Ferrando, Ronald E; French, Dorothy M; Webster, Joshua; Roose-Girma, Merone; Warming, Søren; Dixit, Vishva M

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3 Nature, 2014, ISSN: 0028-0836

Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; Devoss, Jason; Diehl, Lauri; Graham, Robert R; van Lookeren Campagne, Menno

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging Nature, 2014, ISSN: 1476-4687

Ritsma, Laila; Ellenbroek, Saskia I J; Zomer, Anoek; Snippert, Hugo J; de Sauvage, Frederic J; Simons, Benjamin D; Clevers, Hans; van Rheenen, Jacco

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors Cell, 2014, ISSN: 0092-8674

Croci, Diego O; Cerliani, Juan P; Dalotto-Moreno, Tomas; Méndez-Huergo, Santiago P; Mascanfroni, Ivan D; Dergan-Dylon, Sebastián; Toscano, Marta A; Caramelo, Julio J; García-Vallejo, Juan J; Ouyang, Jing; Mesri, Enrique A; Junttila, Melissa R; Bais, Carlos; Shipp, Margaret A; Salatino, Mariana; Rabinovich, Gabriel A

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study The lancet oncology, 2014, ISSN: 1470-2045

McArthur, Grant A; Chapman, Paul B; Robert, Caroline; Larkin, James; Haanen, John B; Dummer, Reinhard; Ribas, Antoni; Hogg, David; Hamid, Omid; Ascierto, Paolo A; Garbe, Claus; Testori, Alessandro; Maio, Michele; Lorigan, Paul; Lebbé, Celeste; Jouary, Thomas; Schadendorf, Dirk; O'Day, Stephen J; Kirkwood, John M; Eggermont, Alexander M; Dréno, Brigitte; Sosman, Jeffrey A; Flaherty, Keith T; Yin, Ming; Caro, Ivor; Cheng, Suzanne; Trunzer, Kerstin; Hauschild, Axel

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria Immunity, 2014, ISSN: 1074-7613

Behnsen, Judith; Jellbauer, Stefan; Wong, Christina P; Edwards, Robert A; George, Michael D; Ouyang, Wenjun; Raffatellu, Manuela

Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis Science Translational Medicine, 2014, ISSN: 1946-6234

Perera, Gayathri K.; Ainali, Chrysanthi; Semenova, Ekaterina; Hundhausen, Christian; Barinaga, Guillermo; Kassen, Deepika; Williams, Andrew E.; Mirza, Muddassar M.; Balazs, Mercedesz; Wang, Xiaoting; Rodriguez, Robert Sanchez; Alendar, Andrej; Barker, Jonathan; Tsoka, Sophia; Ouyang, Wenjun; Nestle, Frank O.

Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers PLoS ONE, 2014, ISSN: 1932-6203

Schleifman, Erica B; Desai, Rupal; Spoerke, Jill M; Xiao, Yuanyuan; Wong, Cheryl; Abbas, Ilma; O'Brien, Carol; Patel, Rajesh; Sumiyoshi, Teiko; Fu, Ling; Tam, Rachel N; Koeppen, Hartmut; Wilson, Timothy R; Raja, Rajiv; Hampton, Garret M; Lackner, Mark R

Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Fauber, Benjamin P; Magnuson, Steven

Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication PLoS ONE, 2014, ISSN: 1932-6203

Degtyarev, Michael; Reichelt, Mike; Lin, Kui

Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: An Eastern Cooperative Oncology Group study (E1405) Blood, 2014, ISSN: 00064971

Chang, Julie E.; Li, Hailun; Smith, Mitchell R.; Gascoyne, Randy D.; Paietta, Elisabeth M.; Yang, David T.; Advani, Ranjana H.; Horning, Sandra J.; Kahl, Brad S.

Th17 cells at the crossroads of autoimmunity, inflammation, and atherosclerosis Immunity, 2014, ISSN: 1097-4180

van Bruggen, Nicholas; Ouyang, Wenjun

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Staben, Steven T; Feng, Jianwen A; Lyle, Karen; Belvin, Marcia; Boggs, Jason; Burch, Jason D; Chua, Ching-Ching; Cui, Haifeng; Dipasquale, Antonio G; Friedman, Lori S; Heise, Christopher; Koeppen, Hartmut; Kotey, Adrian; Mintzer, Robert; Oh, Angela; Roberts, David Allen; Rouge, Lionel; Rudolph, Joachim; Tam, Christine; Wang, Weiru; Xiao, Yisong; Young, Amy; Zhang, Yamin; Hoeflich, Klaus P

Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Journal of Medicinal Chemistry, 2014, ISSN: 0022-2623

Giannetti, Anthony M; Zheng, Xiaozhang; Skelton, Nicholas J; Wang, Weiru; Bravo, Brandon J; Bair, Kenneth W; Baumeister, Timm; Cheng, Eric; Crocker, Lisa; Feng, Yezhen; Gunzner-Toste, Janet; Ho, Yen-Ching; Hua, Rongbao; Liederer, Bianca M; Liu, Yongbo; Ma, Xiaolei; O'Brien, Thomas; Oeh, Jason; Sampath, Deepak; Shen, Youming; Wang, Chengcheng; Wang, Leslie; Wu, Hongxing; Xiao, Yang; Yuen, Po-Wai; Zak, Mark; Zhao, Guiling; Zhao, Qiang; Dragovich, Peter S

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions New England Journal of Medicine, 2014, ISSN: 1533-4406

Goede, Valentin; Fischer, Kirsten; Busch, Raymonde; Engelke, Anja; Eichhorst, Barbara; Wendtner, Clemens M; Chagorova, Tatiana; de la Serna, Javier; Dilhuydy, Marie-Sarah; Illmer, Thomas; Opat, Stephen; Owen, Carolyn J; Samoylova, Olga; Kreuzer, Karl-Anton; Stilgenbauer, Stephan; Döhner, Hartmut; Langerak, Anton W; Ritgen, Matthias; Kneba, Michael; Asikanius, Elina; Humphrey, Kathryn; Wenger, Michael; Hallek, Michael

Discovery of 7-Tetrahydropyran-2-yl Chromans: beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) inhibitors That Reduce Amyloid beta-Protein (A beta) in the Central Nervous System Journal of Medicinal Chemistry, 2014, ISSN: 0022-2623

Thomas, Allen A.; Hunt, Kevin W.; Volgraf, Matthew; Watts, Ryan J.; Liu, Xingrong; Vigers, Guy; Smith, Darin; Sammond, Douglas; Tang, Tony P.; Rhodes, Susan P.; Metcalf, Andrew T.; Brown, Karin D.; Otten, Jennifer N.; Burkard, Michael; Cox, April A.; Do, Mary K. Geck; Dutcher, Darrin; Rana, Sumeet; DeLisle, Robert K.; Regal, Kelly; Wright, Albion D.; Groneberg, Robert; Scearce-Levie, Kimberly; Siu, Michael; Purkey, Hans E.; Lyssikatos, Joseph P.; Gunawardana, Indrani W.

Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor PLoS ONE, 2014, ISSN: 1932-6203

Haddick, Patrick C G; Tom, Irene; Luis, Elizabeth; Quiñones, Gabriel; Wranik, Bernd J; Ramani, Sree R; Stephan, Jean-Philippe; Tessier-Lavigne, Marc; Gonzalez, Lino C

Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib Drug Metabolism and Disposition, 2014, ISSN: 0090-9556

Khojasteh, Siamak Cyrus; Yue, Qin; Ma, Shuguang; Castanedo, Georgette; Chen, Jacob Z; Lyssikatos, Joseph; Mulder, Teresa; Takahashi, Ryan; Ly, Justin; Messick, Kirsten; Jia, Wei; Liu, Lichuan; Hop, Cornelis E C A; Wong, Harvey

Therapeutic opportunities of the IL-22-IL-22R1 system Nature Reviews, 2013, ISSN: 1474-1776

Sabat, Robert; Ouyang, Wenjun; Wolk, Kerstin

EBI2 Is a Negative Regulator of Type I Interferons in Plasmacytoid and Myeloid Dendritic Cells PLoS ONE, 2013, ISSN: 1932-6203

Chiang, Eugene Y; Johnston, Robert J; Grogan, Jane L

Genetics of rheumatoid arthritis contributes to biology and drug discovery Nature, 2013, ISSN: 0028-0836

Okada, Yukinori; Wu, Di; Trynka, Gosia; Raj, Towfique; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Yoshida, Shinji; Graham, Robert R; Manoharan, Arun; Ortmann, Ward; Bhangale, Tushar; Denny, Joshua C; Carroll, Robert J; Eyler, Anne E; Greenberg, Jeffrey D; Kremer, Joel M; Pappas, Dimitrios A; Jiang, Lei; Yin, Jian; Ye, Lingying; Su, Ding-Feng; Yang, Jian; Xie, Gang; Keystone, Ed; Westra, Harm-Jan; Esko, Tõnu; Metspalu, Andres; Zhou, Xuezhong; Gupta, Namrata; Mirel, Daniel; Stahl, Eli A; Diogo, Dorothée; Cui, Jing; Liao, Katherine; Guo, Michael H; Myouzen, Keiko; Kawaguchi, Takahisa; Coenen, Marieke J H; van Riel, Piet L C M; van de Laar, Mart A F J; Guchelaar, Henk-Jan; Huizinga, Tom W J; Dieudé, Philippe; Mariette, Xavier; Louis Bridges Jr, S; Zhernakova, Alexandra; Toes, Rene E M; Tak, Paul P; Miceli-Richard, Corinne; Bang, So-Young; Lee, Hye-Soon; Martin, Javier; Gonzalez-Gay, Miguel A; Rodriguez-Rodriguez, Luis; Rantapää-Dahlqvist, Solbritt; Arl

Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele PLoS ONE, 2013, ISSN: 1932-6203

Kauder, Steven E.; Santell, Lydia; Mai, Elaine; Wright, Lilyan Y.; Luis, Elizabeth; N'Diaye, Elsa N; Lutman, Jeff; Ratti, Navneet; Sa, Susan M.; Maun, Henry R.; Stefanich, Eric; Gonzalez, Lino C.; Graham, Robert R.; Diehl, Lauri; Faubion Jr., William A.; Keir, Mary E.; Young, Judy; Chaudhuri, Amitabha; Lazarus, Robert A.; Egen, Jackson G.

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation Nature Immunology, 2013, ISSN: 1529-2908

Vander Lugt, Bryan; Khan, Aly A; Hackney, Jason A; Agrawal, Smita; Lesch, Justin; Zhou, Meijuan; Lee, Wyne P; Park, Summer; Xu, Min; Devoss, Jason; Spooner, Chauncey J; Chalouni, Cecile; Delamarre, Lelia; Mellman, Ira; Singh, Harinder

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors Journal of medicinal chemistry, 2013, ISSN: 0022-2623

Estrada, Anthony A; Chan, Bryan K; Baker-Glenn, Charles; Beresford, Alan; Burdick, Daniel J; Chambers, Mark; Chen, Huifen; Dominguez, Sara L; Dotson, Jennafer; Drummond, Jason; Flagella, Michael; Fuji, Reina; Gill, Andrew; Halladay, Jason; Harris, Seth F; Heffron, Timothy P; Kleinheinz, Tracy; Lee, Donna W; Pichon, Claire E Le; Liu, Xingrong; Lyssikatos, Joseph P; Medhurst, Andrew D; Moffat, John G; Nash, Kevin; Scearce-Levie, Kimberly; Sheng, Zejuan; Shore, Daniel G; Wong, Susan; Zhang, Shuo; Zhang, Xiaolin; Zhu, Haitao; Sweeney, Zachary K

Lgr5(+) Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration Cell stem cell, 2013, ISSN: 1934-5909

Metcalfe, Ciara; Kljavin, Noelyn M; Ybarra, Ryan; de Sauvage, Frederic J

IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Simonetti, Giorgia; Carette, Amanda; Silva, Kathryn; Wang, Haowei; De Silva, Nilushi S.; Heise, Nicole; Siebel, Christian W.; Shlomchik, Mark J.; Klein, Ulf

PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic kras Science Signaling, 2013, ISSN: 1945-0877

Diaz-Flores, Ernesto; Goldschmidt, Hana; Depeille, Philippe; Ng, Victor; Akutagawa, Jon; Krisman, Kimberly; Crone, Michael; Burgess, Michael R.; Williams, Olusegun; Houseman, Benjamin; Shokat, Kevan; Sampath, Deepak; Bollag, Gideon; Roose, Jeroen P.; Braun, Benjamin S.; Shannon, Kevin

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine Nature Chemical Biology, 2013, ISSN: 1552-4450

Gao, Xinxin; Hannoush, Rami

Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Sudhamsu, Jawahar; Yin, Jianping; Chiang, Eugene Y; Starovasnik, Melissa A; Grogan, Jane L; Hymowitz, Sarah G

Dimerization of LT beta R by LT alpha(1)beta(2) is necessary and sufficient for signal transduction Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Sudhamsu, Jawahar; Yin, JianPing; Chiang, Eugene Y.; Starovasnik, Melissa A.; Grogan, Jane L.; Hymowitz, Sarah G.

Identification of a small peptide that inhibits PCSK9 binding to the low density lipoprotein receptor Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Zhang, Yingnan; Eigenbrot, Charles; Zhou, Lijuan; Shia, Steven; Li, Wei; Quan, Clifford; Tom, Jeffrey; Moran, Paul; Di Lello, Paola; Skelton, Nicholas; Beltran, Monica; Peterson, Andrew; Kirchhofer, Daniel

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Kirkpatrick, Donald S; Bustos, Daisy J; Dogan, Taner; Chan, Jocelyn; Phu, Lilian; Young, Amy; Friedman, Lori S; Belvin, Marcia; Song, Qinghua; Bakalarski, Corey E; Hoeflich, Klaus P

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo Journal of Experimental Medicine, 2013,

Abdel-Wahab O; Gao J; Adli M; Dey A; Trimarchi T; Chung YR; Kuscu C; Hricik T; Ndiaye-Lobry D; Lafave LM; Koche R; Shih AH; Guryanova OA; Kim E; Li S; Pandey S; Shin JY; Telis L; Liu J; Bhatt PK; Monette S; Zhao X; Mason CE; Park CY; Bernstein BE; Aifantis I; Levine RL.

The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199 Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Choo, Edna F; Boggs, Jason; Zhu, Chunqiang; Lubach, Joseph W; Catron, Nathaniel D; Jenkins, Gary; Souers, Andrew; Voorman, Richard

A Nobel Prize for membrane traffic: Vesicles find their journey's end Journal of Cell Biology, 2013, ISSN: 0021-9525

Mellman, Ira; Emr, Scott D

Modulating caspase activity: beyond the active site Current Opinion in Structural Biology, 2013, ISSN: 0959-440X

Murray, Jeremy; Renslo, Adam R

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin Neuron, 2013, ISSN: 0896-6273

Yang, Jing; Weimer, Robby M; Kallop, Dara; Olsen, Olav; Wu, Zhuhao; Renier, Nicolas; Uryu, Kunihiro; Tessier-Lavigne, Marc

Improved Crystallographic Structures Using Extensive Combinatorial Refinement Structure, 2013,

Nwachukwu, Jerome; Southern, Mark; Kiefer, James; Afonine, Pavel; Adams, Paul; Terwilliger, Thomas; Nettles, Kendall

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Susmith Mukund; Yonglei Shang; Holly J Clarke; Azadeh Madjidi; Jacob E Corn; Lance Kates; Ganesh Kolumam; Vicki Chiang; Elizabeth Luis; Jeremy Murray; Yingnan Zhang; Isidro Hötzel; Christopher M Koth; Bernard B Allan

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Pozniak, Christine; Sengupta Ghosh, Arundhati; Gogineni, Alvin; Hanson, Jesse; Lee, Seung-Hye; Larson, Jessica; Solanoy, Hilda; Bustos, Daisy; Li, Hong; Ngu, Hai; Jubb, Adrian; Ayalon, Gai; Wu, Jiansheng; Scearce-Levie, Kimberly; Zhou, Qiang; Weimer, Robby; Kirkpatrick, Donald; Lewcock, Joseph

Inhibition of the p110 alpha isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Soler, Adriana; Serra, Helena; Pearce, Wayne; Angulo, Ana; Guillermet-Guibert, Julie; Friedman, Lori S.; Vinals, Francesc; Gerhardt, Holger; Casanovas, Oriol; Graupera, Mariona; Vanhaesebroeck, Bart

Delta-like notch ligands expressed by host non-hematopoietic radioresistant cells regulate graft-versus-host disease and extrathymic T cell development after bone marrow transplantation Blood, 2013, ISSN: 0006-4971

Ebens, Christen L.; Chung, Jooho; Koch, Ute; Tran, Ivy T.; Sandy-Sloat, Ashley R.; Friedman, Ann; Blazar, Bruce R.; Reddy, Pavan; Yan, Minhong; Siebel, Christian W.; Radtke, Freddy; Maillard, Ivan

Early relapse of follicular lymphoma after R-CHOP uniquely defines patients at high risk for death: An analysis from the national lymphocare study Blood, 2013, ISSN: 0006-4971

Casulo, Carla; Byrtek, Michelle; Dawson, Keith L.; Zhou, Xiaolei; Farber, Charles; Flowers, Christopher R.; Hainsworth, John D.; Link, Brian K.; Zelenetz, Andrew D.; Friedberg, Jonathan W.

Differences in treatment patterns and costs among diffuse large B-cell lymphoma patients treated in the clinic Vs. the hospital outpatient setting Blood, 2013, ISSN: 0006-4971

Reyes, Carolina; Dacosta Byfield, Stacey; Becker, Laura K.; Small, Art

Characterizing the CPG methylation of epstein-barr virus DNA in the plasma of patients with hodgkin lymphoma and HIV-associated burkitt lymphoma Blood, 2013, ISSN: 0006-4971

Kanakry, Jennifer A.; Shamay, Meir; Kasamon, Yvette L.; Li, Hailun; Gascoyne, Randy D.; Gordon, Leo I.; Noy, Ariela; Cesarman, Ethel; Lee, Jeannette Y.; Horning, Sandra J.; Ambinder, Richard F.

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1 Nature Immunology, 2013, ISSN: 1529-2908

Spooner, Chauncey J; Lesch, Justin; Yan, Donghong; Khan, Aly A; Abbas, Alex; Ramirez-Carrozzi, Vladimir; Zhou, Meijuan; Soriano, Robert; Eastham-Anderson, Jeffrey; Diehl, Lauri; Lee, Wyne P; Modrusan, Zora; Pappu, Rajita; Xu, Min; Devoss, Jason; Singh, Harinder

Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Boswell, C. Andrew; Marik, Jan; Elowson, Michael J.; Reyes, Noe A.; Ulufatu, Sheila; Bumbaca, Daniela; Yip, Victor; Mundo, Eduardo E.; Majidy, Nicholas; Van Hoy, Marjie; Goriparthi, Saritha N.; Trias, Anthony; Gill, Herman S.; Williams, Simon P.; Junutula, Jagath R.; Fielder, Paul J.; Khawli, Leslie A.

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins PLoS Pathogens, 2013, ISSN: 1553-7366

Hazenbos, Wouter L W; Kajihara, Kimberly K; Vandlen, Richard; Morisaki, J Hiroshi; Lehar, Sophie M; Kwakkenbos, Mark J; Beaumont, Tim; Bakker, Arjen Q; Phung, Qui; Swem, Lee R; Ramakrishnan, Satish; Kim, Janice; Xu, Min; Shah, Ishita M; Diep, Binh An; Sai, Tao; Sebrell, Andrew; Khalfin, Yana; Oh, Angela; Koth, Chris; Lin, S Jack; Lee, Byoung-Chul; Strandh, Magnus; Koefoed, Klaus; Andersen, Peter S; Spits, Hergen; Brown, Eric J; Tan, Man-Wah; Mariathasan, Sanjeev

The anatomy of successful computational biology software Nature Biotechnology, 2013, ISSN: 1087-0156

Altschul, Stephen; Demchak, Barry; Durbin, Richard; Gentleman, Robert; Krzywinski, Martin; Li, Heng; Nekrutenko, Anton; Robinson, James; Rasband, Wayne; Taylor, James; Trapnell, Cole

ATLAS: Randomized, Double-Blind, Placebo-Controlled, Phase IIIB Trial Comparing Bevacizumab Therapy With or Without Erlotinib, After Completion of Chemotherapy, With Bevacizumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Johnson, Bruce E; Kabbinavar, Fairooz; Fehrenbacher, Louis; Hainsworth, John; Kasubhai, Saifuddin; Kressel, Bruce; Lin, Chin-Yu; Marsland, Thomas; Patel, Taral; Polikoff, Jonathan; Rubin, Mark; White, Leonard; Yang, James Chih-Hsin; Bowden, Chris; Miller, Vincent

Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non-Small-Cell Lung Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Spigel, David R; Ervin, Thomas J; Ramlau, Rodryg A; Daniel, Davey B; Goldschmidt, Jerome H, Jr; Blumenschein, George R, Jr; Krzakowski, Maciej J; Robinet, Gilles; Godbert, Benoit; Barlesi, Fabrice; Govindan, Ramaswamy; Patel, Taral; Orlov, Sergey V; Wertheim, Michael S; Yu, Wei; Zha, Jiping; Yauch, Robert L; Patel, Premal H; Phan, See-Chun; Peterson, Amy C

In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release Nature Medicine, 2013, ISSN: 1078-8956

Scheller, Richard

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Lobsiger, Christian S.; Boillée, Severine; Pozniake, Christine; Khan, Amir M.; McAlonis-Downes, Melissa; Lewcock, Joseph W.; Cleveland, Don W.

The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone PLoS ONE, 2013,

André, Ingemar; Corn, Jacob

Influence of tumour micro-environment heterogeneity on therapeutic response Nature, 2013, ISSN: 0028-0836

Junttila, Melissa; de Sauvage, Frederic

Association of cyp2c9*2 with bosentan-induced liver injury Clinical Pharmacology and Therapeutics, 2013, ISSN: 0009-9236

Jason Halladay

Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an IAP Antagonist Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Wong, Harvey; Gould, Stephen E; Budha, Nageshwar; Darbonne, Walter C; Kadel, Edward E, 3rd; La, Hank; Alicke, Bruno; Halladay, Jason S; Erickson, Rebecca; Portera, Chia; Tolcher, Anthony W; Infante, Jeffrey R; Mamounas, Michael; Flygare, John A; Hop, Cornelis Eca; Fairbrother, Wayne J

Antibody Therapeutics in Cancer Science, 2013, ISSN: 0036-8075

Sliwkowski, Mark X; Mellman, Ira

Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells Nature Immunology, 2013, ISSN: 1529-2908

Rajasekaran, Kamalakannan; Kumar, Pawan; Schuldt, Kristina M.; Peterson, Erik J.; Vanhaesebroeck, Bart; Dixit, Vishva; Thakar, Monica S.; Malarkannan, Subramaniam

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Misaghi, Shahram; Senger, Kate; Sai, Tao; Qu, Yan; Sun, Yonglian; Hamidzadeh, Kajal; Nguyen, Allen; Jin, Zhaoyu; Zhou, Meijuan; Yan, Donghong; Lin, Wei Yu; Lin, Zhonghua; Lorenzo, Maria N; Sebrell, Andrew; Ding, Jiabing; Xu, Min; Caplazi, Patrick; Austin, Cary D; Balazs, Mercedesz; Roose-Girma, Merone; Deforge, Laura; Warming, Søren; Lee, Wyne P; Dixit, Vishva M; Zarrin, Ali A

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2 PLoS ONE, 2013, ISSN: 1932-6203

Nelson, Christopher D; Sheng, Morgan

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma Cancer Cell, 2013, ISSN: 1535-6108

Bhat, Krishna P.L.; Balasubramaniyan, Veerakumar; Vaillant, Brian; Ezhilarasan, Ravesanker; Hummelink, Karlijn; Hollingsworth, Faith; Wani, Khalida; Heathcock, Lindsey; James, Johanna D.; Goodman, Lindsey D.; Conroy, Siobhan; Long, Lihong; Lelic, Nina; Wang, Suzhen; Gumin, Joy; Raj, Divya; Kodama, Yoshinori; Raghunathan, Aditya; Olar, Adriana; Joshi, Kaushal; Pelloski, Christopher E.; Heimberger, Amy; Kim, SeHoon; Cahill, Daniel P.; Rao, Ganesh; DenDunnen, Wilfred F. A.; Boddeke, Hendrikus W.G.M.; Phillips, Heidi S.; Nakano, Ichiro; Lang, Frederick F.; Colman, Howard; Sulman, Erik P.; Aldape, Kenneth

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Welty, Nathan E.; Staley, Christopher; Ghilardi, Nico; Sadowsky, Michael J.; Igyarto, Botond Z.; Kaplan, Daniel H.

Allosteric inhibition of BACE1 by an exosite-binding antibody Current Opinion in Structural Biology, 2013, ISSN: 1879-033X

Wang, Weiru; Liu, Yichin; Lazarus, Robert A

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis Journal of Cell Biology, 2013, ISSN: 0021-9525

Huntwork-Rodriguez, Sarah; Wang, Bei; Watkins, Trent; Ghosh, Arundhati Sengupta; Pozniak, Christine D; Bustos, Daisy; Newton, Kim; Kirkpatrick, Donald S; Lewcock, Joseph W

Fcy receptors enable anticancer action of proapoptotic and immune-modulatory antibodies Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Kim, Jeong; Ashkenazi, Avi

Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results From a Randomized, Double-Blind, Phase III Study Arthritis & Rheumatism, 2013,

Mysler, Eduardo F.; Spindler, Alberto J.; Guzman, Renato; Bijl, Marc; Jayne, David; Furie, Richard A.; Houssiau, Frederic A.; Drappa, Jorn; Close, David; Maciuca, Romeo; Rao, Kajal; Shahdad, Saba; Brunetta, Paul

Regulation of deubiquitinase proteolytic activity Current Opinion in Structural Biology, 2013, ISSN: 0959-440X

Huang, Oscar W; Cochran, Andrea G

Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Johnson, Leisa; Huseni, Mahrukh; Smyczek, Tanya; Lima, Anthony; Yeung, Stacey; Cheng, Jason; Molina, Rafael; Kan, David; De Mazier̀e, Ann; Klumperman, Judith; Kasman, Ian; Zhang, Yin; Dennis, Mark; Eastham-Anderson, Jeffrey; Jubb, Adrian; Hwang, Olivia; Desai, Rupal; Schmidt, Maike; Nannini, Michelle A.; Barck, Kai H.; Carano, Richard A. D.; Forrest, William F.; Song, Qinghua; Chen, Daniel S.; Naumovski, Louie; Singh, Mallika; Ye, Weilan; Hegde, Priti S.

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism Cancer Cell, 2013, ISSN: 1535-6108

Pribluda, Ariel; Elyada, Ela; Wiener, Zoltan; Hamza, Haya; Goldstein, RobertE.; Biton, Moshe; Burstain, Ido; Morgenstern, Yael; Brachya, Guy; Billauer, Hana; Biton, Sharon; Snir-Alkalay, Irit; Vucic, Domagoj; Schlereth, Katharina; Mernberger, Marco; Stiewe, Thorsten; Oren, Moshe; Alitalo, Kari; Pikarsky, Eli; Ben-Neriah, Yinon

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers Nature, 2013, ISSN: 0028-0836

Hatzivassiliou, Georgia; Haling, Jacob R; Chen, Huifen; Song, Kyung; Price, Steve; Heald, Robert; Hewitt, Joanne F M; Zak, Mark; Peck, Ariana; Orr, Christine; Merchant, Mark; Hoeflich, Klaus P; Chan, Jocelyn; Luoh, Shiuh-Ming; Anderson, Daniel J; Ludlam, Mary J C; Wiesmann, Christian; Ultsch, Mark; Friedman, Lori S; Malek, Shiva; Belvin, Marcia

Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors Journal of Clinical Pharmacology, 2013, ISSN: 0091-2700

Xin, Yan; Jin, Denise; Eppler, Stephen; Damico-Beyer, Lisa A; Joshi, Amita; Davis, John D; Kaur, Surinder; Nijem, Ihsan; Bothos, John; Peterson, Amy; Patel, Premal; Bai, Shuang

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy Nature Medicine, 2013,

Chung, Alicia; Xiumin Wu; Zhuang, Guanglei; Ngu, Hai; Kasman, Ian; Zhang, Jianhuan; Vernes, Jean-Michel; Jiang, Zhaoshi; Meng, Gloria; Peale, Franklin; Ouyang, Wenjun; Ferrara, Napoleone

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens Nature Immunology, 2013, ISSN: 1529-2916

Satpathy, Ansuman; Briseno, Carlos; Lee, Jacob; Ng, Dennis; Manieri, Nicholas; KC, Wumesh; Wu, Xiaodi; Thomas, Stephanie; Lee, Wan-Ling; Turkoz, Mustafa; McDonald, Keely; Meredith, Matthew; Song, Christina; Guidos, Cynthia; Newberry, Rodney; Ouyang, Wenjun; Murphy, Theresa; Stappenbeck, Thaddeus; Gommerman, Jennifer; Nussenzweig, Michel; Colonna, Marco; Kopan, Raphael; Murphy, Kenneth

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma Science Translational Medicine, 2013, ISSN: 1946-6234

Corcoran, Ryan B.; Rothenberg, Stephen Michael; Hata, Aaron N.; Faber, Anthony C.; Piris, Adriano; Nazarian, Rosalynn M.; Brown, Ronald D.; Godfrey, Jason T.; Winokur, Daniel; Walsh, John; Mino-Kenudson, Mari; Maheswaran, Shyamala; Settleman, Jeffrey; Wargo, Jennifer A.; Flaherty, Keith T.; Haber, Daniel A.; Engelman, Jeffrey A.

Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Lauffer, Benjamin E L; Mintzer, Robert; Fong, Rina; Mukund, Susmith; Tam, Christine; Zilberleyb, Inna; Flicke, Birgit; Ritscher, Allegra; Fedorowicz, Grazyna; Vallero, Roxanne; Ortwine, Daniel F; Gunzner, Janet; Modrusan, Zora; Neumann, Lars; Koth, Christopher M; Lupardus, Patrick J; Kaminker, Joshua S; Heise, Christopher E; Steiner, Pascal

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death Nature Chemical Biology, 2013, ISSN: 1552-4450

Magnaghi, Paola; D'Alessio, Roberto; Valsasina, Barbara; Avanzi, Nilla; Rizzi, Simona; Asa, Daniela; Gasparri, Fabio; Cozzi, Liviana; Cucchi, Ulisse; Orrenius, Christian; Polucci, Paolo; Ballinari, Dario; Perrera, Claudia; Leone, Antonella; Cervi, Giovanni; Casale, Elena; Xiao, Yang; Wong, Chihunt; Anderson, Daniel J.; Galvani, Arturo; Donati, Daniele; O'Brien, Tom; Jackson, Peter K.; Isacchi, Antonella

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition PLoS ONE, 2013, ISSN: 1932-6203

Hanson, Jesse E; La, Hank; Plise, Emile; Chen, Yung-Hsiang; Ding, Xiao; Hanania, Taleen; Sabath, Emily V; Alexandrov, Vadim; Brunner, Dani; Leahy, Emer; Steiner, Pascal; Liu, Lichuan; Scearce-Levie, Kimberly; Zhou, Qiang

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 Science, 2013, ISSN: 0036-8075

Kayagaki, Nobuhiko; Wong, Michael T; Stowe, Irma B; Ramani, Sree Ranjani; Gonzalez, Lino C; Akashi-Takamura, Sachiko; Miyake, Kensuke; Zhang, Juan; Lee, Wyne P; Muszynski, Artur; Forsberg, Lennart S; Carlson, Russell W; Dixit, Vishva M

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity Immunity, 2013, ISSN: 1097-4180

Wang, Yaya; Shaked, Iftach; Stanford, StephanieM.; Zhou, Wenbo; Curtsinger, JulieM.; Mikulski, Zbigniew; Shaheen, ZacharyR.; Cheng, Genhong; Sawatzke, Kristy; Campbell, AmandaM.; Auger, JenniferL.; Bilgic, Hatice; Shoyama, FernandaM.; Schmeling, DavidO.; Balfour, HenryH.; Hasegawa, Kiminori; Chan, Andrew C.; Corbett, JohnA.; Binstadt, BryceA.; Mescher, MatthewF.; Ley, Klaus; Bottini, Nunzio; Peterson, ErikJ.

Label-Free High Throughput Assays to Screen and Characterize Novel Lactate Dehydrogenase Inhibitors Analytical Biochemistry, 2013, ISSN: 1096-0309

Vanderporten, Erica; Frick, Lauren; Turincio, Rebecca; Thana, Peter; Lamarr, William; Liu, Yichin

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Merchant, Mark; Ma, Xiaolei; Maun, Henry R; Zheng, Zhong; Peng, Jing; Romero, Mally; Huang, Arthur; Yang, Nai-Ying; Nishimura, Merry; Greve, Joan; Santell, Lydia; Zhang, Yu-Wen; Su, Yanli; Kaufman, Dafna W; Billeci, Karen L; Mai, Elaine; Moffat, Barbara; Lim, Amy; Duenas, Eileen T; Phillips, Heidi S; Xiang, Hong; Young, Judy C; Vande Woude, George F; Dennis, Mark S; Reilly, Dorothea E; Schwall, Ralph H; Starovasnik, Melissa A; Lazarus, Robert A; Yansura, Daniel G

Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Spiess, Christoph; Bevers, Jack, 3rd; Jackman, Janet; Chiang, Nancy; Nakamura, Gerald; Dillon, Michael; Liu, Hongbin; Molina, Patricia; Elliott, J Michael; Shatz, Whitney; Scheer, Justin M; Giese, Glen; Persson, Josefine; Zhang, Yin; Dennis, Mark S; Giulianotti, James; Gupta, Prateek; Reilly, Dorothea; Palma, Enzo; Wang, Jianyong; Stefanich, Eric; Scheerens, Heleen; Fuh, Germaine; Wu, Lawren C

An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza a antibodies Cell Host & Microbe, 2013, ISSN: 1931-3128

Nakamura, Gerald; Chai, Ning; Park, Summer; Chiang, Nancy; Lin, Zhonghua; Chiu, Henry; Fong, Rina; Yan, Donghong; Kim, Janice; Zhang, Juan; Lee, Wyne P; Estevez, Alberto; Coons, Mary; Xu, Min; Lupardus, Patrick; Balazs, Mercedesz; Swem, Lee R

Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis PLoS ONE, 2013, ISSN: 1932-6203

Gogineni, Alvin; Caunt, Maresa; Crow, Ailey; Lee, Chingwei V; Fuh, Germaine; van Bruggen, Nicholas; Ye, Weilan; Weimer, Robby M

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling Blood, 2013, ISSN: 0006-4971

Wilson, Christopher; Parker, Leon; Hall, Christopher; Smyczek, Tanya; Mak, Judy; Crow, Ailey; Posthuma, George; De Mazière, Ann; Sagolla, Meredith; Chalouni, Cecile; Vitorino, Philip; Roose-Girma, Merone; Warming, Søren; Klumperman, Judith; Crosier, Philip; Ye, Weilan

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Zheng, Xiaozhang; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Lin, Jian; Reynolds, Dominic J.; Sharma, Geeta; Smith, Chase C.; Wang, Zhongguo; Dragovich, Peter S.; Oh, Angela; Wang, Weiru; Zak, Mark; Gunzner-Toste, Janet; Zhao, Guiling; Yuen, Po-Wai; Bair, Kenneth W.

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response - art. no. e1003472 PLoS Pathogens, 2013, ISSN: 1553-7374

Kozakiewicz, Lee; Chen, Yong; Xu, Jiayong; Wang, Yanhua; Dunussi-Joannopoulos, Kyri; Ou, Qinglin; Flynn, Joanne L.; Porcelli, Steven A.; Jacobs, William R., Jr.; Chan, John

A Rare Population of CD24+ITGB4+Notch hi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal Cancer Cell, 2013, ISSN: 1535-6108

Zheng, Yanyan; de la Cruz, Cecile C.; Sayles, Leanne C.; Alleyne-Chin, Chris; Vaka, Dedeepya; Knaak, Tim D.; Bigos, Marty; Xu, Yue; Hoang, Chuong D.; Shrager, Joseph B.; Fehling, HansJoerg; French, Dorothy; Forrest, William; Jiang, Zhaoshi; Carano, Richard A.D.; Barck, Kai H.; Jackson, Erica L.; Sweet-Cordero, E. Alejandro

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies Nature Biotechnology, 2013, ISSN: 1087-0156

Christoph Spiess; Mark Merchant; Arthur Huang; Zhong Zheng; Nai-Ying Yang; Jing Peng; Diego Ellerman; Whitney Shatz; Dorothea Reilly; Daniel G Yansura; Justin M Scheer

Decoding a Chain Letter for Degradation Structure, 2013, ISSN: 0969-2126

Cunningham, Christian N; Corn, Jacob E

Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development Proceedings of the National Academy of Sciences, 2013,

Chen, Hao; Brady Ridgway, John; Sai, Tao; Lai, Joyce; Warming, Søren; Chen, Hanying; Roose-Girma, Merone; Zhang, Gu; Shou, Weinian; Yan, Minhong

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes Nature, 2013, ISSN: 1476-4687

Kumar, Ritu; DiMenna, Lauren; Schrode, Nadine; Liu, Ting-Chun; Franck, Philipp; Munoz-Descalzo, Silvia; Hadjantonakis, Anna-Katerina; Zarrin, Ali A.; Chaudhuri, Jayanta; Elemento, Olivier; Evans, Todd

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling Proceedings of the National Academy of Sciences, 2013, ISSN: 1091-6490

Phillips, Aaron H.; Zhang, Yingnan; Cunningham, Christian N.; Zhou, Lijuan; Forrest, William F.; Liu, Peter S.; Steffek, Micah; Lee, James; Tam, Christine; Helgason, Elizabeth; Murray, Jeremy M.; Kirkpatrick, Donald S.; Fairbrother, Wayne J.; Corn, Jacob E.

Signaling via the IL-20 receptor inhibits cutaneous production of IL-1 beta and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus Nature Immunology, 2013, ISSN: 1529-2908

Myles, Ian A.; Fontecilla, Natalia M.; Valdez, Patricia A.; Vithayathil, Paul J.; Naik, Shruti; Belkaid, Yasmine; Ouyang, Wenjun; Datta, Sandip K.

Critical Review of Preclinical Approaches to Investigate Cytochrome P450-Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper Drug Metabolism and Disposition, 2013,

Evers, Raymond; Dallas, Shannon; Dickmann, Leslie J.; Fahmi, Odette A.; Kenny, Jane R.; Kraynov, Eugenia; Theresa Nguyen; Patel, Aarti H.; Slatter, J. Greg; Zhang, Lei

miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer PLoS ONE, 2013,

Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Oh, Jaehak; Wu, Nan; Baravalle, Guenther; Cohn, Benjamin; Ma, Jessica; Lo, Bryan; Mellman, Ira; Ishido, Satoshi; Anderson, Mark; Shin, Jeoung-Sook

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study The Lancet Oncology, 2013, ISSN: 1470-2045

Swain, Sandra M.; Kim, Sung-Bae; Cortés, Javier; Ro, Jungsil; Semiglazov, Vladimir; Campone, Mario; Ciruelos, Eva; Ferrero, Jean-Marc; Schneeweiss, Andreas; Knott, Adam; Clark, Emma; Ross, Graham; Benyunes, Mark C.; Baselga, José

A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: Suppression of CYP3A by IL-6 Clinical Pharmacology and Therapeutics, 2013, ISSN: 0009-9236

MacHavaram, K.K.; Almond, L.M.; Rostami-Hodjegan, A.; Gardner, I.; Jamei, M.; Tay, S.; Wong, S.; Joshi, A.; Kenny, J.R.

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Zindl, Carlene L.; Lai, Jen-Feng; Lee, Yun Kyung; Maynard, Craig L.; Harbour, Stacey N.; Ouyang, Wenjun; Chaplin, David D.; Weaver, Casey T.

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays PLoS ONE, 2013, ISSN: 1932-6203

Chan, Grace Ka Yan; Kleinheinz, Tracy L; Peterson, David; Moffat, John G

Two-in-One antibodies with dual action Fabs Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931

Eigenbrot, Charles; Fuh, Germaine

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Liang, Jun; van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade; Chang, Christine; Delarosa, Donnie; Devoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Halladay, Jason; Johnson, Adam; Kohli, Pawan Bir; Lai, Yingjie; Liu, Yanzhou; Lyssikatos, Joseph; Mantik, Priscilla; Menghrajani, Kapil; Murray, Jeremy; Peng, Ivan; Sambrone, Amy; Shia, Steven; Shin, Young; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Wu, Lawren C; Xiao, Yisong; Yang, Wenqian; Young, Judy; Zhang, Birong; Zhu, Bing-Yan; Magnuson, Steven

Discovery of 2-{3-2-(1-Isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzofimidazo1,2-d1,4oxazepin-9-yl-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Ndubaku, Chudi O; Heffron, Timothy P; Staben, Steven T; Baumgardner, Matthew; Blaquiere, Nicole; Bradley, Erin; Bull, Richard; Do, Steven; Dotson, Jennafer; Dudley, Danette; Edgar, Kyle A; Friedman, Lori S; Goldsmith, Richard; Heald, Robert A; Kolesnikov, Aleksandr; Lee, Leslie; Lewis, Cristina; Nannini, Michelle; Nonomiya, Jim; Pang, Jodie; Price, Steve; Prior, Wei Wei; Salphati, Laurent; Sideris, Steve; Wallin, Jeffery J; Wang, Lan; Wei, Binqing; Sampath, Deepak; Olivero, Alan G

Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Zak, Mark; Hurley, Christopher A; Ward, Stuart I; Bergeron, Philippe; Barrett, Kathy; Balazs, Mercedesz; Blair, Wade S; Bull, Richard; Chakravarty, Paroma; Chang, Christine; Crackett, Peter; Deshmukh, Gauri; Devoss, Jason; Dragovich, Peter S; Eigenbrot, Charles; Ellwood, Charles; Gaines, Simon; Ghilardi, Nico; Gibbons, Paul; Gradl, Stefan; Gribling, Peter; Hamman, Chris; Harstad, Eric; Hewitt, Peter; Johnson, Adam; Johnson, Tony; Kenny, Jane R; Koehler, Michael F T; Bir Kohli, Pawan; Labadie, Sharada; Lee, Wyne P; Liao, Jiangpeng; Liimatta, Marya; Mendonca, Rohan; Narukulla, Raman; Pulk, Rebecca; Reeve, Austin; Savage, Scott; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; van Abbema, Anne; Aliagas, Ignacio; Avitabile-Woo, Barbara; Xiao, Yisong; Yang, Jing; Kulagowski, Janusz J

Recapitulating human cancer in a mouse Nature Biotechnology, 2013, ISSN: 1087-0156

Chin, Lynda; De Sauvage, Frederic; Egeblad, Mikala; Olive, Kenneth P.; Tuveson, David; Weiss, William

Evaluation of Tumor-Size Response Metrics to Predict Overall Survival in Western and Chinese Patients With First-Line Metastatic Colorectal Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Claret, Laurent; Gupta, Manish; Han, Kelong; Joshi, Amita; Sarapa, Nenad; He, Jing; Powell, Bob; Bruno, René

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier Science Translational Medicine, 2013, ISSN: 1946-6234

Couch, Jessica A; Yu, Y Joy; Zhang, Yin; Tarrant, Jacqueline M; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Tong, Raymond K; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Gadkar, Kapil; Prabhu, Saileta; Ordonia, Benjamin A; Nguyen, Quyen; Lin, Yuwen; Lin, Zhonghua; Balazs, Mercedesz; Scearce-Levie, Kimberly; Ernst, James A; Dennis, Mark S; Watts, Ryan J

EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS PLoS ONE, 2013, ISSN: 1932-6203

Le Pichon, Claire E; Dominguez, Sara L; Solanoy, Hilda; Ngu, Hai; Lewin-Koh, Nicholas; Chen, Mark; Eastham-Anderson, Jeffrey; Watts, Ryan; Scearce-Levie, Kimberly

Optimization of drug-drug interaction study design: Comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Han, Bing; Mao, Jialin; Chien, Jenny Y.; Hall, Stephen D.

Variability in P-Glycoprotein Inhibitory Potency (IC 50 ) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug- Drug Interaction Risk Assessment Decision Criterias Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Bentz, Joe; O'Connor, Michael P.; Bednarczyk, Dallas; Coleman, Joann; Lee, Caroline; Palm, Johan; Pak, Y. Anne; Perloff, Elke S.; Reyner, Eric; Balimane, Praveen; Brännström, Marie; Chu, Xiaoyan; Funk, Christoph; Guo, Ailan; Hanna, Imad; Herédi-Szabó, Krisztina; Hillgren, Kate; Li, Libin; Hollnack-Pusch, Evelyn; Jamei, Masoud; Lin, Xuena; Mason, Andrew K.; Neuhoff, Sibylle; Patel, Aarti; Podila, Lalitha; Plise, Emile; Rajaraman, Ganesh; Salphati, Laurent; Sands, Eric; Taub, Mitchell E.; Taur, Jan-Shiang; Weitz, Dietmar; Wortelboer, Heleen M.; Xia, Cindy Q.; Xiao, Guangqing; Yabut, Jocelyn; Yamagata, Tetsuo; Zhang, Lei; Ellens, Harma

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactionss Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Ellens, Harma; Deng, Shibing; Coleman, Joann; Bentz, Joe; Taub, Mitchell E.; Ragueneau-Majlessi, Isabelle; Chung, Sophie P.; Herédi-Szabó, Krisztina; Neuhoff, Sibylle; Palm, Johan; Balimane, Praveen; Zhang, Lei; Jamei, Masoud; Hanna, Imad; O'connor, Michael; Bednarczyk, Dallas; Forsgard, Malin; Chu, Xiaoyan; Funk, Christoph; Guo, Ailan; Hillgren, Kathleen M.; Li, Libin; Pak, Anne Y.; Perloff, Elke S.; Rajaraman, Ganesh; Salphati, Laurent; Taur, Jan-Shiang; Weitz, Dietmar; Wortelboer, Heleen M.; Xia, Cindy Q.; Xiao, Guangqing; Yamagata, Tetsuo; Lee, Caroline A.

Structure-guided design of a selective BCL-X-L inhibitor Nature Chemical Biology, 2013, ISSN: 1552-4450

Lessene, Guillaume; Czabotar, Peter E.; Sleebs, Brad E.; Zobel, Kerry; Lowes, Kym N.; Adams, Jerry M.; Baell, Jonathan B.; Colman, Peter M.; Deshayes, Kurt; Fairbrother, Wayne J.; Flygare, John A.; Gibbons, Paul; Kersten, Wilhelmus J. A.; Kulasegaram, Sanji; Moss, Rebecca M.; Parisot, John P.; Smith, Brian J.; Street, Ian P.; Yang, Hong; Huang, David C. S.; Watson, Keith G.

Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases Science Signaling, 2013, ISSN: 1945-0877

Zhuang, Guanglei; Yu, Kebing; Jiang, Zhaoshi; Chung, Alicia; Yao, Jenny; Ha, Connie; Toy, Karen; Soriano, Robert; Haley, Benjamin; Blackwood, Elizabeth; Sampath, Deepak; Bais, Carlos; Lill, Jennie R; Ferrara, Napoleone

Sustainable practices in medicinal chemistry: current state and future directions Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Bryan, Marian C; Dillon, Barry; Hamann, Lawrence G; Hughes, Gregory J; Kopach, Michael E; Peterson, Emily A; Pourashraf, Mehrnaz; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen F

Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Liu, Xingrong; Wong, Harvey; Scearce-Levie, Kimberly; Watts, Ryan; Coraggio, Melis; Shin, Young; Peng, Kun; Wildsmith, Kristin; Atwal, Jasvinder; Mango, Jason; Schauer, Stephen; Regal, Kelly; Hunt, Kevin; Thomas, Allen; Siu, Mike; Lyssikatos, Joseph; Deshmukh, Gauri; Hop, Cornelis

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Cohn, Lillian; Chatterjee, Bithi; Esselborn, Filipp; Smed-Sörensen, Anna; Nakamura, Norihiro; Chalouni, Cécile; Lee, Byoung-Chul; Vandlen, Richard; Keler, Tibor; Lauer, Peter; Brockstedt, Dirk; Mellman, Ira; Delamarre, Lélia

Bispecific antibodies for delivery into the brain Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931

Watts, Ryan J; Dennis, Mark S

Blockade of individual notch ligands and receptors controls graft-versus-host disease Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Tran, Ivy T.; Sandy, Ashley R.; Carulli, Alexis J.; Ebens, Christen; Chung, Jooho; Shan, Gloria T.; Radojcic, Vedran; Friedman, Ann; Gridley, Thomas; Shelton, Amy; Reddy, Pavan; Samuelson, Linda C.; Yan, Minhong; Siebel, Christian W.; Maillard, Ivan

Blockade of individual Notch ligands and receptors to control graft-versus-host disease Journal of Clinical Investigation, 2013,

Ivy T Tran; Ashley R Sandy; Alexis J Carulli; Christen Ebens; Jooho Chung; Gloria T Shan; Vedran Radojcic; Ann Friedman; Thomas Gridley; Amy Shelton; Pavan Reddy; Linda C Samuelson; Minhong Yan; Christian W Siebel; Ivan Maillard

OTUB1 modulates c-IAP1 stability to regulate signalling pathways EMBO Journal, 2013, ISSN: 0261-4189

Goncharov, Tatiana; Niessen, Kyle; de Almagro, Maria Cristina; Izrael-Tomasevic, Anita; Fedorova, Anna V; Varfolomeev, Eugene; Arnott, David; Deshayes, Kurt; Kirkpatrick, Donald S; Vucic, Domagoj

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Hunt, Kevin W.; Cook, Adam W.; Watts, Ryan J.; Clark, Christopher T.; Vigers, Guy; Smith, Darin; Metcalf, Andrew T.; Gunawardana, Indrani W.; Burkard, Michael; Cox, April A.; Geck Do, Mary K.; Dutcher, Darrin; Thomas, Allen A.; Rana, Sumeet; Kallan, Nicholas C.; Delisle, Robert K.; Rizzi, James P.; Regal, Kelly; Sammond, Douglas; Groneberg, Robert; Siu, Michael; Purkey, Hans; Lyssikatos, Joseph P.; Marlow, Allison; Liu, Xingrong; Tang, Tony P.

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Phan, Vernon; Wu, Xiumin; Cheng, Jason; Sheng, Rebecca; Chung, Alicia; Zhuang, Guanglei; Tran, Christopher; Song, Qinghua; Kowanetz, Marcin; Sambrone, Amy; Tan, Martha; Meng, Gloria; Jackson, Erica; Peale, Franklin; Junttila, Melissa; Ferrara, Napoleone

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung PLOS GENETICS, 2013, ISSN: 1553-7404

Calvi, Carla; Podowski, Megan; Lopez-Mercado, Armando; Metzger, Shana; Misono, Kaori; Malinina, Alla; Dikeman, Dustin; Poonyagariyon, Hataya; Ynalvez, Leslie; Derakhshandeh, Roshanak; Le, Anne; Merchant, Mark; Schwall, Ralph; Neptune, Enid R.

Rer1p maintains ciliary length and signaling by regulating gamma-secretase activity and Foxj1a levels Journal of Cell Biology, 2013, ISSN: 0021-9525

Jurisch-Yaksi, Nathalie; Rose, Applonia J.; Lu, Huiqi; Raemaekers, Tim; Munck, Sebastian; Baatsen, Pieter; Baert, Veerle; Vermeire, Wendy; Scales, Suzie J.; Verleyen, Daphne; Vandepoel, Roel; Tylzanowski, Przemko; Yaksi, Emre; de Ravel, Thomy; Yost, H. Joseph; Froyen, Guy; Arrington, Cammon B.; Annaert, Wim

Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR) Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Estrada, Anthony A; Shore, Daniel G; Blackwood, Elizabeth; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Dipasquale, Antonio G; Epler, Jennifer A; Friedman, Lori S; Koehler, Michael F T; Liu, Lichuan; Malek, Shiva; Nonomiya, Jim; Ortwine, Daniel F; Pei, Zhonghua; Sideris, Steve; St-Jean, Frederic; Trinh, Lan; Truong, Tom; Lyssikatos, Joseph P

Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study Journal of Clinical Pharmacology, 2013, ISSN: 0091-2700

George, Samuel; Rodriguez, Ignacio; Ipe, David; Sager, Philip T.; Gussak, Ihor; Vajdic, Branislav

PAR-1 contributes to the innate immune response during viral infection Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Antoniak, Silvio; Owens III, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, Jo Ann; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma Cell, 2013, ISSN: 0092-8674

Snuderl, Matija; Batista, Ana; Kirkpatrick, Nathaniel D.; De Almodovar, Carmen Ruiz; Riedemann, Lars; Walsh, Elisa C.; Anolik, Rachel; Huang, Yuhui; Martin, John D.; Kamoun, Walid; Knevels, Ellen; Schmidt, Thomas; Farrar, Christian T.; Vakoc, Benjamin J.; Mohan, Nishant; Chung, Euiheon; Roberge, Sylvie; Peterson, Teresa; Bais, Carlos; Zhelyazkova, Boryana H.; Yip, Stephen; Hasselblatt, Martin; Rossig, Claudia; Niemeyer, Elisabeth; Ferrara, Napoleone; Klagsbrun, Michael; Duda, Dan G.; Fukumura, Dai; Xu, Lei; Carmeliet, Peter; Jain, Rakesh K.

Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type i serine proteases Fromtransmembrane anchors Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Raman, Kavita; Trivedi, Neil N.; Raymond, Wilfred W.; Ganesan, Rajkumar; Kirchhofer, Daniel; Verghese, George M.; Craik, Charles S.; Schneider, Eric L.; Nimishakavi, Shilpa; Caughey, George H.

Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia PLoS ONE, 2013, ISSN: 1932-6203

Wu, Ai-Luen; Feng, Bo; Chen, Mark Z; Kolumam, Ganesh; Zavala-Solorio, Jose; Wyatt, Shelby K; Gandham, Vineela D; Carano, Richard A D; Sonoda, Junichiro

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Watkins, Trent A; Wang, Bei; Huntwork-Rodriguez, Sarah; Yang, Jing; Jiang, Zhiyu; Eastham-Anderson, Jeffrey; Modrusan, Zora; Kaminker, Joshua S; Tessier-Lavigne, Marc; Lewcock, Joseph W

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Kearney, Conor J.; Sheridan, Clare; Cullen, Sean P.; Tynan, Graham A.; Logue, Susan E.; Afonina, Inna S.; Vucic, Domagoj; Lavelle, Ed C.; Martin, Seamus J.

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery EMBO Reports, 2013, ISSN: 1469-221X

Lee, Dong Yun; Arnott, David; Brown, Eric J.

Personalizing medicine for autoimmune and inflammatory diseases Nature Immunology, 2013, ISSN: 1529-2908

Chan, Andrew C.; Behrens, Timothy W.

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance Blood, 2013, ISSN: 0006-4971

Lee, Sung-Uk; Maeda, Manami; Ishikawa, Yuichi; Li, Sierra Min; Wilson, Anne; Jubb, Adrian M.; Sakurai, Nagisa; Weng, Lihong; Fiorini, Emma; Radtke, Freddy; Yan, Minhong; MacDonald, H. Robson; Chen, Ching-Cheng; Maeda, Takahiro

Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer Science Translational Medicine, 2013, ISSN: 1946-6234

Hegde, Ganapati V; de la Cruz, Cecile C; Chiu, Cecilia; Alag, Navneet; Schaefer, Gabriele; Crocker, Lisa; Ross, Sarajane; Goldenberg, David; Merchant, Mark; Tien, Janet; Shao, Lily; Roth, Leslie; Tsai, Siao-Ping; Stawicki, Scott; Jin, Zhaoyu; Wyatt, Shelby K; Carano, Richard A D; Zheng, Yanyan; Sweet-Cordero, E Alejandro; Wu, Yan; Jackson, Erica L

Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice PLoS ONE, 2013,

Sarikonda, Ghanashyam; Sachithanantham, Sowbarnika; Manenkova, Yulia; Kupfer, Tinalyn; Posgai, Amanda; Wasserfall, Clive; Bernstein, Philip; Straub, Laura; Pagni, Philippe P.; Schneider, Darius; Calvo, Teresa Rodriguez; Coulombe, Marilyne; Herold, Kevan; Gill, Ronald G.; Atkinson, Mark; Nepom, Gerald; Ehlers, Mario; Staeva, Teodora; Garren, Hideki; Steinman, Lawrence; Chan, Andrew C.; von Herrath, Matthias

Phase II Randomized Study of Trastuzumab Emtansine Versus Trastuzumab Plus Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Postive Metastatic Breast Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Hurvitz, Sara A; Dirix, Luc; Kocsis, Judit; Bianchi, Giulia V; Lu, Janice; Vinholes, Jeferson; Guardino, Ellie; Song, Chunyan; Tong, Barbara; Ng, Vivian; Chu, Yu-Waye; Perez, Edith A

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling Science, 2013, ISSN: 0036-8075

Huang, Xiaodong; McGann, James C; Liu, Bob Y; Hannoush, Rami N; Lill, Jennie R; Pham, Victoria; Newton, Kim; Kakunda, Michael; Liu, Jinfeng; Yu, Christine; Hymowitz, Sarah G; Hongo, Jo-Anne; Wynshaw-Boris, Anthony; Polakis, Paul; Harland, Richard M; Dixit, Vishva M

The burden of faulty proofreading in colon cancer Nature Genetics, 2013, ISSN: 1061-4036

Seshagiri, Somasekar

Neuroscience: Strength in numbers Nature, 2013, ISSN: 0028-0836

Sheng, Morgan; Malinow, Roberto; Huganir, Richard

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling Cell, 2013, ISSN: 0092-8674

Mukhopadhyay, Saikat; Wen, Xiaohui; Ratti, Navneet; Loktev, Alexander; Rangell, Linda; Scales, Suzie J; Jackson, Peter K

Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial The Lancet Oncology, 2013, ISSN: 1470-2045

Bennouna, Jaafar; Sastre, Javier; Arnold, Dirk; Österlund, Pia; Greil, Richard; Van Cutsem, Eric; von Moos, Roger; Viéitez, Jose Maria; Bouché, Olivier; Borg, Christophe; Steffens, Claus-Christoph; Alonso-Orduña, Vicente; Schlichting, Christoph; Reyes-Rivera, Irmarie; Bendahmane, Belguendouz; André, Thierry; Kubicka, Stefan

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models Cancer Cell, 2013, ISSN: 1535-6108

Corcoran, Ryan B.; Cheng, Katherine A.; Hata, Aaron N.; Faber, Anthony C.; Ebi, Hiromichi; Coffee, Erin M.; Greninger, Patricia; Brown, Ronald D.; Godfrey, Jason T.; Cohoon, Travis J.; Song, Youngchul; Lifshits, Eugene; Hung, Kenneth E.; Shioda, Toshi; Dias-Santagata, Dora; Singh, Anurag; Settleman, Jeffrey; Benes, Cyril H.; Mino-Kenudson, Mari; Wong, Kwok-Kin; Engelman, Jeffrey A.

The Akt DUBbed InAktive Science Signaling, 2013,

Lin, Kui

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Nature Medicine, 2013, ISSN: 1078-8956

Souers, Andrew J.; Leverson, Joel D.; Boghaert, Erwin R.; Ackler, Scott L.; Catron, Nathaniel D.; Chen, Jun; Dayton, Brian D.; Ding, Hong; Enschede, Sari H.; Fairbrother, Wayne J.; Huang, David C. S.; Hymowitz, Sarah G.; Jin, Sha; Khaw, Seong Lin; Kovar, Peter J.; Lam, Lloyd T.; Lee, Jackie; Maecker, Heather L.; Marsh, Kennan C.; Mason, Kylie D.; Mitten, Michael J.; Nimmer, Paul M.; Oleksijew, Anatol; Park, Chang H.; Park, Cheol-Min; Phillips, Darren C.; Roberts, Andrew W.; Sampath, Deepak; Seymour, John F.; Smith, Morey L.; Sullivan, Gerard M.; Tahir, Stephen K.; Tse, Chris; Wendt, Michael D.; Xiao, Yu; Xue, John C.; Zhang, Haichao; Humerickhouse, Rod A.; Rosenberg, Saul H.; Elmore, Steven W.

Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody-Drug Conjugates Analytical Chemistry, 2013, ISSN: 0003-2700

Chen, Jia; Yin, Sheng; Wu, Yongjian; Ouyang, Jun

A tumor-specific stem cell Nature Genetics, 2012, ISSN: 1061-4036

Metcalfe, Ciara; de Sauvage, Frederic J

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways Journal of Cell Biology, 2012, ISSN: 0021-9525

Lo, Bryan; Strasser, Geraldine; Sagolla, Meredith; Austin, Cary D.; Junttila, Melissa; Mellman, Ira

Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators PLoS ONE, 2012, ISSN: 1932-6203

Scheer, Justin M; Sandoval, Wendy; Elliott, J Michael; Shao, Lily; Luis, Elizabeth; Lewin-Koh, Sock-Cheng; Schaefer, Gabriele; Vandlen, Richard

Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genetics, 2012,

Bendesky, Andres; Pitts, Jason; Rockman, Matthew; Chen, William; Tan, Man-Wah; Kruglyak, Leonid; Bargmann, Cornelia

Application of a new wall-less plate technology to complex multi-step cell-based investigations using suspension cells Blood, 2012, ISSN: 0006-4971

Quiñones, Gabriel A; Moore, Travis I; Nicholes, Katrina; Lee, Hyunjae; Kim, Sudong; Sun, Laura; Jeon, Noo Li; Stephan, Jean-Philippe

Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel PLoS ONE, 2012,

Patel, Rajesh; Tsan, Alison; Tam, Rachel; Desai, Rupal; Schoenbrunner, Nancy; Myers, Thomas W.; Bauer, Keith; Smith, Edward; Raja, Rajiv

Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Polucci, Paolo; Magnaghi, Paola; Angiolini, Mauro; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Bertrand, Jay; Casale, Elena; Cauteruccio, Silvia; Cirla, Alessandra; Cozzi, Liviana; Galvani, Arturo; Jackson, Peter K.; Liu, Yichin; Magnuson, Steven; Malgesini, Beatrice; Nuvoloni, Stefano; Orrenius, Christian; Sirtori, Federico Riccardi; Riceputi, Laura; Rizzi, Simona; Trucchi, Beatrice; O'Brien, Tom; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto

Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria Immunity, 2012,

Basu, Rajatava; O’Quinn, Darrell; Silberger, Daniel; Schoeb, Trenton; Fouser, Lynette; Ouyang, Wenjun; Hatton, Robin; Weaver, Casey

Cyanide Anion as a Leaving Group in Nucleophilic Aromatic Substitution: Synthesis of Quaternary Centers at Azine Heterocycles Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Thompson, Alexander D; Huestis, Malcolm P

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations Science Translational Medicine, 2012, ISSN: 1946-6234

Sheng, Zejuan; Zhang, Shuo; Bustos, Daisy; Kleinheinz, Tracy; Le Pichon, Claire E; Dominguez, Sara L; Solanoy, Hilda O; Drummond, Jason; Zhang, Xiaolin; Ding, Xiao; Cai, Fang; Song, Qinghua; Li, Xianting; Yue, Zhenyu; van der Brug, Marcel P; Burdick, Daniel J; Gunzner-Toste, Janet; Chen, Huifen; Liu, Xingrong; Estrada, Anthony A; Sweeney, Zachary K; Scearce-Levie, Kimberly; Moffat, John G; Kirkpatrick, Donald S; Zhu, Haitao

The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-like Superfamily Biochemistry, 2012, ISSN: 1520-4995

Parsiegla, Goetz; Noguere, Christophe; Santell, Lydia; Lazarus, Robert A.; Bourne, Yves

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 PLoS ONE, 2012, ISSN: 1932-6203

Heise, Christopher E; Murray, Jeremy; Augustyn, Katherine E; Bravo, Brandon; Chugha, Preeti; Cohen, Frederick; Giannetti, Anthony M; Gibbons, Paul; Hannoush, Rami N; Hearn, Brian R; Jaishankar, Priyadarshini; Ly, Cuong Q; Shah, Kinjalkumar; Stanger, Karen; Steffek, Micah; Tang, Yinyan; Zhao, Xianrui; Lewcock, Joseph W; Renslo, Adam R; Flygare, John; Arkin, Michelle R

Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-amino-1,2,3-thiadiazole Drug Metabolism and Disposition, 2012, ISSN: 0090-9556

Yue, Qin; Mulder, Teresa; Rudewicz, Patrick J; Solon, Eric; Budha, Nageshwar; Ware, Joseph A; Lyssikatos, Joseph; Hop, Cornelis E C A; Wong, Harvey; Khojasteh, S Cyrus

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 Nature Immunology, 2012, ISSN: 1529-2908

Wang, Chenhui; Wu, Ling; Bulek, Katarzyna; Martin, Bradley N.; Zepp, Jarod A.; Kang, Zizhen; Liu, Caini; Herjan, Tomasz; Misra, Saurav; Carman, Julie A.; Gao, Ji; Dongre, Ashok; Han, Shujie; Bunting, Kevin D.; Ko, Jennifer S.; Xiao, Hui; Kuchroo, Vijay K.; Ouyang, Wenjun; Li, Xiaoxia

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase Journal of Biological Chemistry, 2012, ISSN: 0021-9258

King, Gordon J.; Stöckli, Jacqueline; Hu, Shu-Hong; Winnen, Brit; Duprez, Wilko G. A.; Meoli, Christopher C.; Junutula, Jagath R.; Jarrott, Russell J.; James, David E.; Whitten, Andrew E.; Martin, Jennifer L.

Potent, selective, and orally bioavailable inhibitors of the Mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Koehler, Michael F T; Bergeron, Philippe; Blackwood, Elizabeth; Bowman, Krista K; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Epler, Jennifer; Lau, Kevin; Lee, Leslie; Liu, Lichuan; Ly, Cuong; Malek, Shiva; Nonomiya, Jim; Oeh, Jason; Ortwine, Daniel F; Sampath, Deepak; Sideris, Steve; Trinh, Lan; Truong, Tom; Wu, Jiansheng; Pei, Zhonghua; Lyssikatos, Joseph P

Identification of mutant KRas-dependent phenotypes using a panel of isogenic cell lines Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Vartanian, Steffan; Bentley, Carolyn; Brauer, Matthew J; Li, Li; Shirasawa, Senji; Sasazuki, Takehiko; Kim, Jun-Sik; Haverty, Pete; Stawiski, Eric; Modrusan, Zora; Waldman, Todd; Stokoe, David

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7 Nature Chemical Biology, 2012, ISSN: 1552-4450

Zhang, Yingnan; Zhou, Lijuan; Rouge, Lionel; Phillips, Aaron H; Lam, Cynthia; Liu, Peter; Sandoval, Wendy; Helgason, Elizabeth; Murray, Jeremy M; Wertz, Ingrid E; Corn, Jacob E

Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Li, Jing; Zhi, Jianguo; Wenger, Michael; Valente, Nancy; Dmoszynska, Anna; Robak, Tadeusz; Mangat, Ranvir; Joshi, Amita; Visich, Jennifer

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletss Journal of Pharmacology and Experimental Therapeutics, 2012, ISSN: 0022-3565

Li, Xiaoyan Nina; Herrington, James; Petrov, Aleksandr; Ge, Lan; Eiermann, George; Xiong, Yusheng; Jensen, Mette V.; Hohmeier, Hans E.; Newgard, Christopher B.; Garcia, Maria L.; Wagner, Michael; Zhang, Bei B.; Thornberry, Nancy A.; Howard, Andrew D.; Kaczorowski, Gregory J.; Zhou, Yun-Ping

Pharmacokinetics and pharmacodynamics of anti-BR3 monoclonal antibody in mice Pharmaceutical Research, 2012, ISSN: 0724-8741

Marathe, Anshu; Iyer, Suhasini; Qiu, Zhihua Julia; Visich, Jennifer; Mager, Donald E.

TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias Cell, 2012, ISSN: 0092-8674

Jackson, Peter;

Improving risk assessment Science Translational Medicine, 2012, ISSN: 1946-6234

Dambach, Donna M; Uppal, Hirdesh

Furin-cleaved PCSK9 is active and modulates LDL receptor and serum cholesterol levels Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Lipari, Michael T; Li, Wei; Moran, Paul; Kong-Beltran, Monica; Sai, Tao; Lai, Joyce; Lin, S Jack; Kolumam, Ganesh; Zavala-Solorio, Jose; Izrael-Tomasevic, Anita; Arnott, David; Wang, Jianyong; Peterson, Andrew S; Kirchhofer, Daniel

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer Molecular Cell, 2012,

Gonzalvez, Francois; Lawrence, David; Yang, Becky; Yee, Sharon; Pitti, Robert; Marsters, Scot; Pham, Victoria C; Stephan, Jean-Philippe; Lill, Jennie; Ashkenazi, Avi

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci American Journal of Human Genetics, 2012, ISSN: 0002-9297

Asselbergs, Folkert W.; Guo, Yiran; Van Iperen, Erik P.A.; Sivapalaratnam, Suthesh; Tragante, Vinicius; Lanktree, Matthew B.; Lange, Leslie A.; Almoguera, Berta; Appelman, Yolande E.; Barnard, John; Baumert, Jens; Beitelshees, Amber L.; Bhangale, Tushar R.; Chen, Yii-Der Ida; Gaunt, Tom R.; Gong, Yan; Hopewell, Jemma C.; Johnson, Toby; Kleber, Marcus E.; Langaee, Taimour Y.; Li, Mingyao; Li, Yun R.; Liu, Kiang; McDonough, Caitrin W.; Meijs, Matthijs F.L.; Middelberg, Rita P.S.; Musunuru, Kiran; Nelson, Christopher P.; O'Connell, Jeffery R.; Padmanabhan, Sandosh; Pankow, James S.; Pankratz, Nathan; Rafelt, Suzanne; Rajagopalan, Ramakrishnan; Romaine, Simon P.R.; Schork, Nicholas J.; Shaffer, Jonathan; Shen, Haiqing; Smith, Erin N.; Tischfield, Sam E.; Van Der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Verweij, Niek; Volcik, Kelly A.; Zhang, Li; Bailey, Kent R.; Bailey, Kristian M.; Bauer, Florianne; Boer, Jolanda M.A.; Braund, Peter S.; Burt, Amber; Burton, Paul R.; Buxbaum, Sarah

Characterization of rat liver proteins adducted by reactive metabolites of menthofuran Chemical Research in Toxicology, 2012, ISSN: 0893-228X

Khojasteh, S. Cyrus; Hartley, Dylan P.; Ford, Kevin A.; Uppal, Hirdesh; Oishi, Shimako; Nelson, Sidney D.

Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity PloS ONE, 2012, ISSN: 1932-6203

Hegde, Ganapati V; de la Cruz, Cecile; Eastham-Anderson, Jeffrey; Zheng, Yanyan; Sweet-Cordero, E Alejandro; Jackson, Erica L

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine Nature, 2012,

Huber, Samuel; Gagliani, Nicola; Zenewicz, Lauren; Huber Francis; Bosurgi, Lidia; Hu, Bo; Hedl Matija; Zhang, Wei; O’Connor, William; Murphy, Andrew; Valenzuela, David; Yancopoulos, George; Booth, Carmen; Cho, Judy; Ouyang, Wenjun; Abraham, Clara; Flavell, Richard

Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function Cell, 2012, ISSN: 0092-8674

Jin, Jing; Sison, Karen; Li, Chengjin; Tian, Ruijun; Wnuk, Monika; Sung, Hoon-Ki; Jeansson, Marie; Zhang, Cunjie; Tucholska, Monika; Jones, Nina; Kerjaschki, Dontscho; Shibuya, Masabumi; Fantus, I. George; Nagy, Andras; Gerber, Hans-Peter; Ferrara, Napoleone; Pawson, Tony; Quaggin, Susan E.

Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P.

Evaluation of semi-homogeneous assay formats for dual-specificity antibodies Journal of Immunological Methods, 2012, ISSN: 1872-7905

Jiang, Guoying; Lee, Chung W; Wong, Pin Yee; Gazzano-Santoro, Hélène

Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial Nature Reviews, 2012, ISSN: 1474-1733

Horvath, Christopher; Andrews, Laura; Baumann, Andreas; Black, Lauren; Blanset, Diann; Cavagnaro, Joy; Hastings, Kenneth; Hutto, David; MacLachlan, Timothy; Milton, Mark; Reynolds, Theresa; Roberts, Stan; Rogge, Mark; Sims, Jennifer; Treacy, George; Warner, Garvin; Green, James;

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer New England Journal of Medicine, 2012, ISSN: 0028-4793

Verma, Sunil; Miles, David; Gianni, Luca; Krop, Ian E; Welslau, Manfred; Baselga, José; Pegram, Mark; Oh, Do-Youn; Diéras, Véronique; Guardino, Ellie; Fang, Liang; Lu, Michael W; Olsen, Steven; Blackwell, Kim

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification Cell, 2012, ISSN: 0092-8674

Samstein, Robert M.; Arvey, Aaron; Josefowicz, Steven Z.; Peng, Xiao; Reynolds, Alex; Sandstrom, Richard; Neph, Shane; Sabo, Peter; Kim, Jeong M.; Liao, Will; Li, Ming O.; Leslie, Christina; Stamatoyannopoulos, John A.; Rudensky, Alexander Y.

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Parikh, Chaitali; Janakiraman, Vasantharajan; Wu, Wen-I; Foo, Catherine K; Kljavin, Noelyn M; Chaudhuri, Subhra; Stawiski, Eric; Lee, Brian; Lin, Jie; Li, Hong; Lorenzo, Maria N; Yuan, Wenlin; Guillory, Joseph; Jackson, Marlena; Rondon, Jesus; Franke, Yvonne; Bowman, Krista K; Sagolla, Meredith; Stinson, Jeremy; Wu, Thomas D; Wu, Jiansheng; Stokoe, David; Stern, Howard M; Brandhuber, Barbara J; Lin, Kui; Skelton, Nicholas J; Seshagiri, Somasekar

Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans Pharmaceutical Research, 2012, ISSN: 0724-8741

Xin, Yan; Bai, Shuang; Damico-Beyer, Lisa A.; Jin, Denise; Liang, Wei-Ching; Wu, Yan; Theil, Frank-Peter; Joshi, Amita; Lu, Yanmei; Lowe, John; Maia, Mauricio; Brachmann, Rainer K.; Xiang, Hong

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT Blood, 2012, ISSN: 0006-4971

Mali, Raghuveer Singh; Ma, Peilin; Zeng, Li-Fan; Martin, Holly; Ramdas, Baskar; He, Yantao; Sims, Emily; Nabinger, Sarah; Ghosh, Joydeep; Sharma, Namit; Munugalavadla, Veerendra; Chatterjee, Anindya; Li, Shuo; Sandusky, George; Craig, Andrew W.; Bunting, Kevin D.; Feng, Gen-Sheng; Chan, Rebecca J.; Zhang, Zhong-Yin; Kapur, Reuben

Development of an ELISA based bridging assay as a surrogate measure of ADCC Journal of Immunological Methods, 2012, ISSN: 0022-1759

Miller, Aaron S; Tejada, Max L; Gazzano-Santoro, Hélène

Genomic landscape of liver cancer Nature Genetics, 2012, ISSN: 1061-4036

Zhang, Zemin;

Pharmacokinetic Considerations for Antibody Drug Conjugates Pharmaceutical Research, 2012, ISSN: 0724-8741

Lin, Kedan; Tibbitts, Jay

Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial The Lancet Oncology, 2012, ISSN: 1470-2045

Ismael, Gustavo; Hegg, Roberto; Muehlbauer, Susanne; Heinzmann, Dominik; Lum, Bert; Kim, Sung-Bae; Pienkowski, Tadeusz; Lichinitser, Mikhail; Semiglazov, Vladimir; Melichar, Bohuslav; Jackisch, Christian

Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human Drug Metabolism and Disposition, 2012, ISSN: 0090-9556

Salphati, Laurent; Pang, Jodie; Plise, Emile G.; Lee, Leslie B.; Olivero, Alan G.; Prior, Wei Wei; Sampath, Deepak; Wong, Susan; Zhang, Xiaolin

Childhood disorders of the synapse: Challenges and opportunities Science Translational Medicine, 2012, ISSN: 1946-6234

Hughes, Virginia; Sheng, Morgan; Zoghbi, Huda

Compensatory dendritic cell development mediated by BATF-IRF interactions Nature, 2012, ISSN: 0028-0836

Tussiwand, Roxane; Lee, Wan-Ling; Murphy, Theresa L.; Mashayekhi, Mona; Kc, Wumesh; Albring, Jörn C.; Satpathy, Ansuman T.; Rotondo, Jeffrey A.; Edelson, Brian T.; Kretzer, Nicole M.; Wu, Xiaodi; Weiss, Leslie A.; Glasmacher, Elke; Li, Peng; Liao, Wei; Behnke, Michael; Lam, Samuel S. K.; Aurthur, Cora T.; Leonard, Warren J.; Singh, Harinder; Stallings, Christina L.; David Sibley, L.; Schreiber, Robert D.; Murphy, Kenneth M.

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging PLoS ONE, 2012, ISSN: 1932-6203

Kamath, Amrita V; Williams, Simon P; Bullens, Sherry; Cowan, Kyra J; Stenberg, Yvonne; Cherry, Simon R; Rendig, Stephen; Kukis, David L; Griesemer, Chris; Damico-Beyer, Lisa A; Bunting, Stuart

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Estrada, Anthony A.; Liu, Xingrong; Baker-Glenn, Charles; Beresford, Alan; Burdick, Daniel J.; Chambers, Mark; Chan, Bryan K.; Chen, Huifen; Ding, Xiao; Dipasquale, Antonio G.; Dominguez, Sara L.; Dotson, Jennafer; Drummond, Jason; Flagella, Michael; Flynn, Sean; Fuji, Reina; Gill, Andrew; Gunzner-Toste, Janet; Harris, Seth F.; Heffron, Timothy P.; Kleinheinz, Tracy; Lee, Donna W.; Le Pichon, Claire E.; Lyssikatos, Joseph P.; Medhurst, Andrew D.; Moffat, John G.; Mukund, Susmith; Nash, Kevin; Scearce-Levie, Kimberly; Sheng, Zejuan; Shore, Daniel G.; Tran, Thuy; Trivedi, Naimisha; Wang, Shumei; Zhang, Shuo; Zhang, Xiaolin; Zhao, Guiling; Zhu, Haitao; Sweeney, Zachary K.

A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1-IRF Complexes Science, 2012, ISSN: 0036-8075

Glasmacher, Elke; Agrawal, Smita; Chang, Abraham B; Murphy, Theresa L; Zeng, Wenwen; Vander Lugt, Bryan; Khan, Aly A; Ciofani, Maria; Spooner, Chauncey; Rutz, Sascha; Hackney, Jason; Nurieva, Roza; Escalante, Carlos R; Ouyang, Wenjun; Littman, Dan R; Murphy, Kenneth M; Singh, Harinder

Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Chudasama, V.L.; Schaedeli Stark, F.; Harrold, J.M.; Tibbitts, J.; Girish, S.R.; Gupta, M.; Frey, N.; Mager, D.E.

Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies Pharmaceutical Research, 2012, ISSN: 0724-8741

Yin, Sheng; Pastuskovas, Cinthia V; Khawli, Leslie A; Stults, John T

Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 is Linked to TNF-ALPHA Pharmacology Toxicological Sciences, 2012, ISSN: 1096-0929

Erickson, Rebecca Ida; Tarrant, Jacqueline; Cain, Gary; Lewin-Koh, Sock-Cheng; Dybdal, Noel; Wong, Harvey; Blackwood, Elizabeth; West, Kristina; Steigerwalt, Ronald; Mamounas, Michael; Flygare, John A; Amemiya, Kenjie; Dambach, Donna; Fairbrother, Wayne J; Diaz, Dolores

S1P1 inhibits sprouting angiogenesis during vascular development Development, 2012, ISSN: 0950-1991

Shoham, Adi Ben; Malkinson, Guy; Krief, Sharon; Shwartz, Yulia; Ely, Yona; Ferrara, Napoleone; Yaniv, Karina; Zelzer, Elazar

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Liu, Yanqiu; Berendsen, Agnes D.; Jia, Shidong; Lotinun, Sutada; Baron, Roland; Ferrara, Napoleone; Olsen, Bjorn R.

The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Heffron, Timothy P.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Dotson, Jennafer; Edgar, Kyle; Goldsmith, Richard; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Ndubaku, Chudi; Nonomiya, Jim; Olivero, Alan G.; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Trapp, Sean; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer Nature Genetics, 2012, ISSN: 1061-4036

Rudin, Charles M.; Durinck, Steffen; Stawiski, Eric W.; Poirier, John T.; Modrusan, Zora; Shames, David S.; Bergbower, Emily A.; Guan, Yinghui; Shin, James; Guillory, Joseph; Rivers, Celina Sanchez; Foo, Catherine K.; Bhatt, Deepali; Stinson, Jeremy; Gnad, Florian; Haverty, Peter M.; Gentleman, Robert; Chaudhuri, Subhra; Janakiraman, Vasantharajan; Jaiswal, Bijay S.; Parikh, Chaitali; Yuan, Wenlin; Zhang, Zemin; Koeppen, Hartmut; Wu, Thomas D.; Stern, Howard M.; Yauch, Robert L.; Huffman, Kenneth E.; Paskulin, Diego D.; Illei, Peter B.; Varella-Garcia, Marileila; Gazdar, Adi F.; De Sauvage, Frederic J.; Bourgon, Richard; Minna, John D.; Brock, Malcolm V.; Seshagiri, Somasekar

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Blake, James F.; Xu, Rui; Bencsik, Josef R.; Xiao, Dengming; Kallan, Nicholas C.; Schlachter, Stephen; Mitchell, Ian S.; Spencer, Keith L.; Banka, Anna L.; Wallace, Eli M.; Gloor, Susan L.; Martinson, Matthew; Woessner, Richard D.; Vigers, Guy P.A.; Brandhuber, Barbara J.; Liang, Jun; Safina, Brian S.; Li, Jun; Zhang, Birong; Chabot, Christine; Do, Steven; Lee, Leslie; Oeh, Jason; Sampath, Deepak; Lee, Brian B.; Lin, Kui; Liederer, Bianca M.; Skelton, Nicholas J.

Recurrent R-spondin fusions in colon cancer Nature, 2012, ISSN: 0028-0836

Seshagiri, Somasekar; Stawiski, Eric W. ; Durinck, Steffen; Modrusan, Zora; Storm, Elaine E.; Conboy, Caitlin B.; Chaudhuri, Subhra; Guan, Yinghui; Janakiraman, Vasantharajan; Jaiswal, Bijay S.; Guillory, Joseph; Ha, Connie; Dijkgraaf, Gerrit J. P. ;Stinson, Jeremy; Gnad, Florian; Huntley, Melanie A.; Degenhardt, Jeremiah D.; Haverty, Peter M.; Bourgon, Richard; Wang, Weiru ; Koeppen, Hartmut; Gentleman, Robert; Starr, Timothy K.; Zhang, Zemin; Largaespada, David A.; Wu, Thomas D. ; de Sauvage, Frederic J.

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Blood, 2012, ISSN: 0006-4971

Merino, Delphine; Khaw, Seong L.; Glaser, Stefan P.; Anderson, Daniel J.; Belmont, Lisa D.; Wong, Chihunt; Yue, Peng; Robati, Mikara; Phipson, Belinda; Fairlie, Walter D.; Lee, Erinna F.; Campbell, Kirsteen J.; Vandenberg, Cassandra J.; Cory, Suzanne; Roberts, Andrew W.; Ludlam, Mary J. C.; Huang, David C. S.; Bouillet, Philippe

Real-time quantification of antibody-siRNA conjugate in serum by antigen-capture RT-PCR Analytical Biochemistry, 2012, ISSN: 0003-2697

Tan, Martha; Vernes, Jean-Michel; Chan, Joyce; Cuellar, Trinna L; Asundi, Aarati; Nelson, Christopher; Yip, Victor; Shen, Ben; Vandlen, Richard; Siebel, Christian; Gloria Meng, Y

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site Structure, 2012, ISSN: 0969-2126

de Leon-Boenig, Gladys; Bowman, Krista K; Feng, Jianwen A; Crawford, Terry; Everett, Christine; Franke, Yvonne; Oh, Angela; Stanley, Mark; Staben, Steven T; Starovasnik, Melissa A; Wallweber, Heidi J A; Wu, Jiansheng; Wu, Lawren C; Johnson, Adam R; Hymowitz, Sarah G

Profiling Antibody Drug Conjugate Positional Isomers: A System-of-Equations Approach Analytical Chemistry, 2012, ISSN: 0003-2700

Le, Lan N; Moore, Jamie M R; Ouyang, Jun; Chen, Xiaoying; Nguyen, Mary D H; Galush, William J

Molecular basis for negative regulation of the glucagon receptor Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Koth, Christopher M; Murray, Jeremy M; Mukund, Susmith; Madjidi, Azadeh; Minn, Alexandra; Clarke, Holly J; Wong, Terence; Chiang, Vicki; Luis, Elizabeth; Estevez, Alberto; Rondon, Jesus; Zhang, Yingnan; Hötzel, Isidro; Allan, Bernard B

Effectiveness of First-Line Management Strategies for Stage I Follicular Lymphoma: Analysis of the National LymphoCare Study Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Friedberg, Jonathan W; Byrtek, Michelle; Link, Brian K; Flowers, Christopher; Taylor, Michael; Hainsworth, John; Cerhan, James R; Zelenetz, Andrew D; Hirata, Jamie; Miller, Thomas P

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 Nature, 2012, ISSN: 0028-0836

Broz, Petr; Ruby, Thomas; Belhocine, Kamila; Bouley, Donna M.; Kayagaki, Nobuhiko; Dixit, Vishva M.; Monack, Denise M.

Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Cirrincione-Dall, Georgina; Brennan, Barbara J.; Ballester-Sanchis, Rosa M.; Navarro, Mercidita T.; Davies, Brian E.

Phosphorylation of NLRC4 is critical for inflammasome activation Nature, 2012, ISSN: 0028-0836

Qu, Yan; Misaghi, Shahram; Izrael-Tomasevic, Anita; Newton, Kim; Gilmour, Laurie L; Lamkanfi, Mohamed; Louie, Salina; Kayagaki, Nobuhiko; Liu, Jinfeng; Kömüves, László; Cupp, James E; Arnott, David; Monack, Denise; Dixit, Vishva M

The genetics of type I interferon in systemic lupus erythematosus Current Opinion in Immunology, 2012,

Bronson, Paola; Chaivorapol, Christina; Ortmann, Ward; Behrens, Timothy; Graham, Robert;

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation Science, 2012, ISSN: 0036-8075

Dey, Anwesha; Seshasayee, Dhaya; Noubade, Rajkumar; French, Dorothy M; Liu, Jinfeng; Chaurushiya, Mira S; Kirkpatrick, Donald S; Pham, Victoria C; Lill, Jennie R; Bakalarski, Corey E; Wu, Jiansheng; Phu, Lilian; Katavolos, Paula; Lafave, Lindsay M; Abdel-Wahab, Omar; Modrusan, Zora; Seshagiri, Somasekar; Dong, Ken; Lin, Zhonghua; Balazs, Mercedesz; Suriben, Rowena; Newton, Kim; Hymowitz, Sarah; Garcia-Manero, Guillermo; Martin, Flavius; Levine, Ross L; Dixit, Vishva M

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Murray, Jeremy M.; Sweeney, Zachary K.; Chan, Bryan K.; Balazs, Mercedesz; Bradley, Erin; Castanedo, Georgette; Chabot, Christine; Chantry, David; Flagella, Michael; Goldstein, David M.; Kondru, Rama; Lesnick, John; Li, Jun; Lucas, Matthew C.; Nonomiya, Jim; Pang, Jodie; Price, Stephen; Salphati, Laurent; Safina, Brian; Savy, Pascal P. A.; Seward, Eileen M.; Ultsch, Mark; Sutherlin, Daniel P.

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature, 2012,

Jonsson T; Atwal JK; Steinberg S; Snaedal J; Jonsson PV; Bjornsson S; Stefansson H; Sulem P; Gudbjartsson D; Maloney J; Hoyte K; Gustafson A; Liu Y; Lu Y; Bhangale T; Graham RR; Huttenlocher J; Bjornsdottir G; Andreassen OA; Jönsson EG; Palotie A; Behrens TW; Magnusson OT; Kong A; Thorsteinsdottir U; Watts RJ; Stefansson K.

Pari passu dimers of dimers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Sliwkowski, Mark;

Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis Toxicological Sciences, 2012,

Wong, Harvey; Budha, Nageshwar; West, Kristina; Blackwood, Elizabeth; Ware, Joseph; Yu, Ron; Darbonne, Walter; Gould, Stephen; Steigerwalt, Ronald; Erickson, Rebecca; Hop, Cornelis; LoRusso, Patricia; Eckhardt, Gail; Wagner, Andrew;Chan, Iris; Mamounas, Michael; Flygare, John; Fairbrother, Wayne

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors Nature, 2012,

Wilson, Timothy; Fridlyand, Jane; Yan, Yibing; Penuel, Elicia; Burton, Luciana; Chan, Emily; Peng, Jing; Lin, Eva; Wang, Yulei; Sosman, Jeff; Ribas, Antoni; Li, Jiang; Moffat, John; Sutherlin, Daniel; Koeppen, Hartmut; Merchant, Mark; Neve, Richard; Settleman, Jeff;

Evaluation of an Accurate Mass Approach for the Simultaneous Detection of Drug and Metabolite Distributions via Whole-Body Mass Spectrometric Imaging Analytical Chemistry, 2012, ISSN: 0003-2700

Shahidi-Latham, Sheerin K.; Dutta, Sucharita M.; Conaway, Maria C. Prieto; Rudewicz, Patrick J.

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair Blood, 2012, ISSN: 0006-4971

Willenborg, Sebastian; Lucas, Tina; Van Loo, Geert; Knipper, Johanna A.; Krieg, Thomas; Haase, Ingo; Brachvogel, Bent; Hammerschmidt, Matthias; Nagy, Andras; Ferrara, Napoleone; Pasparakis, Manolis; Eming, Sabine A.

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease Blood, 2012, ISSN: 0006-4971

Chantrathammachart, Pichika; Mackman, Nigel; Sparkenbaugh, Erica; Wang, Jian-Guo; Parise, Leslie V.; Kirchhofer, Daniel; Key, Nigel S.; Pawlinski, Rafal

Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Pasqua, Adele E.; Ferrari, Frank D.; Hamman, Chris; Liu, Yanzhou; Crawford, James J.; Marquez, Rodolfo

Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Zak, Mark; Mendonca, Rohan; Balazs, Mercedesz; Barrett, Kathy; Bergeron, Philippe; Blair, Wade S; Chang, Christine; Deshmukh, Gauri; Devoss, Jason; Dragovich, Peter S; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Gradl, Stefan; Hamman, Chris; Hanan, Emily J; Harstad, Eric; Hewitt, Peter R; Hurley, Christopher A; Jin, Tian; Johnson, Adam; Johnson, Tony; Kenny, Jane R; Koehler, Michael F T; Bir Kohli, Pawan; Kulagowski, Janusz J; Labadie, Sharada; Liao, Jiangpeng; Liimatta, Marya; Lin, Zhonghua; Lupardus, Patrick J; Maxey, Robert J; Murray, Jeremy M; Pulk, Rebecca; Rodriguez, Madeleine; Savage, Scott; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; Ultsch, Mark; van Abbema, Anne; Ward, Stuart I; Xiao, Ling; Xiao, Yisong

Quantification and Characterization of Micrometer and Submicrometer Subvisible Particles in Protein Therapeutics by Use of a Suspended Microchannel Resonator. Analytical Chemistry, 2012, ISSN: 0003-2700

Patel, Ankit R; Lau, Doris; Liu, Jun

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells Blood, 2012,

Chatterjee, Bithi; Smed-Sörensen, Anna; Cohn, Lillian; Chalouni, Cécile; Vandlen, Richard; Lee, Byoung-Chul; Widger, Jenifer; Keler, Tibor; Delamarre, Lélia; Mellman, Ira

Identification and Characterization of Buried Unpaired Cysteines in a Recombinant Monoclonal IgG1 Antibody Analytical Chemistry, 2012, ISSN: 0003-2700

Zhang, Taylor; Zhang, Jennifer; Hewitt, Daniel; Ben Tran; Gao, Xiaoying; Qiu, Zhihua Julia; Tejada, Max; Gazzano-Santoro, Helene; Kao, Yung-Hsiang

Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth. Cancer cell, 2012, ISSN: 1535-6108

Wilson, Nicholas S; Yang, Annie; Yang, Becky; Couto, Suzana; Stern, Howard; Gogineni, Alvin; Pitti, Robert; Marsters, Scot; Weimer, Robby M; Singh, Mallika; Ashkenazi, Avi

The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients British Journal of Clinical Pharmacology, 2012, ISSN: 0007-1188

Polson, Andrew G.; Fuji, Reina N.

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway EMBO Journal, 2012, ISSN: 0261-4189

Zhuang, Guanglei; Wu, Xiumin; Jiang, Zhaoshi; Kasman, Ian; Yao, Jenny; Guan, Yinghui; Oeh, Jason; Modrusan, Zora; Bais, Carlos; Sampath, Deepak; Ferrara, Napoleone

Reversible modification of APC with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Tran, Hoanh; Polakis, Paul

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Argaw, Azeb Tadesse; Asp, Linnea; Zhang, Jingya; Navrazhina, Kristina; Pham, Trinh; Mariani, John N.; Mahase, Sean; Dutta, Dipankar J.; Seto, Jeremy; Kramer, Elisabeth G.; Ferrara, Napoleone; Sofroniew, Michael V.; John, Gareth R.

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Budha, N R; Frymoyer, A; Smelick, G S; Jin, J Y; Yago, M R; Dresser, M J; Holden, S N; Benet, L Z; Ware, J A

Reply to "On the differentiation of mouse IgE(+) cells" Nature Immunology, 2012, ISSN: 1529-2908

Talay, Oezcan; Yan, Donghong; Brightbill, Hans D; Straney, Elizabeth E M; Zhou, Meijuan; Ladi, Ena; Lee, Wyne P; Egen, Jackson G; Austin, Cary D; Xu, Min; Wu, Lawren C

Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection Analytical Chemistry, 2012, ISSN: 0003-2700

Michels, David A; Tu, Andrea W; McElroy, Will; Voehringer, David; Salas-Solano, Oscar

Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding PLoS ONE, 2012, ISSN: 1932-6203

Nakamura, Gerald R; Fonseca, Dora P A J; O'Rourke, Sara M; Vollrath, Aaron L; Berman, Phillip W

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nature Chemical Biology, 2012, ISSN: 1552-4450

Stanger, Karen; Steffek, Micah; Zhou, Lijuan; Pozniak, Christine D; Quan, Clifford; Franke, Yvonne; Tom, Jeff; Tam, Christine; Elliott, J Michael; Lewcock, Joseph W; Zhang, Yingnan; Murray, Jeremy; Hannoush, Rami N

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Heald, Robert A.; Jackson, Philip; Savy, Pascal; Jones, Mark; Gancia, Emanuela; Burton, Brenda; Newman, Richard; Boggs, Jason; Chan, Emily; Chan, Jocelyn; Choo, Edna; Merchant, Mark; Rudewicz, Patrick; Ultsch, Mark; Wiesmann, Christian; Yue, Qin; Belvin, Marcia; Price, Steve

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma New England Journal of Medicine, 2012, ISSN: 1533-4406

Sekulic, Aleksandar; Migden, Michael R.; Oro, Anthony E.; Dirix, Luc; Lewis, Karl D.; Hainsworth, John D.; Solomon, James A.; Yoo, Simon; Arron, Sarah T.; Friedlander, Philip A.; Marmur, Ellen; Rudin, Charles M.; Chang, Anne Lynn S.; Low, Jennifer A.; Mackey, Howard M.; Yauch, Robert L.; Graham, Richard A.; Reddy, Josina C.; Hauschild, Axel

FOXO3a and β-catenin co-localization: double trouble in colon cancer? Nature Medicine, 2012, ISSN: 1078-8956

Yan, Yibing; Lackner, Mark R

Structural and Functional Analysis of HtrA1 and Its Subdomains Structure, 2012, ISSN: 0969-2126

Eigenbrot, Charles; Ultsch, Mark; Lipari, Michael T.; Moran, Paul; Lin, S. Jack; Ganesan, Rajkumar; Quan, Clifford; Tom, Jeffrey; Sandoval, Wendy; Campagne, Menno van Lookeren; Kirchhofer, Daniel

Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b + Gr1 + cells: Key role of Stat3 signaling Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Qu, Xueping; Zhuang, Guanglei; Yu, Lanlan; Meng, Gloria; Ferrara, Napoleone

A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2 -Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Krop, Ian E; Lorusso, Patricia; Miller, Kathy D; Modi, Shanu; Yardley, Denise; Rodriguez, Gladys; Guardino, Ellie; Lu, Michael; Zheng, Maoxia; Girish, Sandhya; Amler, Lukas; Winer, Eric P; Rugo, Hope S

Origin of Immunoglobulin Isotype Switching Current Biology, 2012, ISSN: 0960-9822

Zhu, Catherine; Lee, Victor; Finn, Alyssa; Senger, Kate; Zarrin, Ali A.; Du Pasquier, Louis; Hsu, Ellen

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Ma, Xiaolei; Helgason, Elizabeth; Phung, Qui T.; Quan, Clifford L.; Iyer, Rekha S.; Lee, Michelle W.; Bowman, Krista K.; Starovasnik, Melissa A.; Dueber, Erin C.

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Chen, Youjun; Chalouni, Cecile; Tan, Christine; Clark, Robyn; Venook, Rayna; Ohri, Rachana; Raab, Helga; Firestein, Ron; Mallet, William; Polakis, Paul;

Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery Drug Metabolism and Disposition, 2012,

Liu, Xingrong; Ding, Xiao; Deshmukh, Gauri; Liederer, Bianca M; Hop, Cornelis;

Clinical Implications of Pathophysiological and Demographic Covariates on the Population Pharmacokinetics of Trastuzumab Emtansine, a HER2-Targeted Antibody-Drug Conjugate, in Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Gupta, Manish; LoRusso, Patricia M; Wang, Bei; Yi, Joo-Hee; Burris, Howard A; Beeram, Muralidhar; Modi, Shanu; Chu, Yu-Waye; Agresta, Samuel; Klencke, Barbara; Joshi, Amita; Girish, Sandhya;

Quantification of Antiangiogenic and Antivascular Drug Activity by Kinetic Analysis of DCE-MRI Data Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Ferl, Greg; Port, Ruediger;

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling. Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Chen, Huifen; Chan, Bryan K; Drummond, Jason; Estrada, Anthony A; Gunzner-Toste, Janet; Liu, Xingrong; Liu, Yichin; Moffat, John; Shore, Daniel; Sweeney, Zachary K; Tran, Thuy; Wang, Shumei; Zhao, Guiling; Zhu, Haitao; Burdick, Daniel J

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models PLoS One, 2012, ISSN: 1932-6203

French, Dorothy M; Lin, Benjamin C; Wang, Manping; Adams, Camellia; Shek, Theresa; Hotzel, Kathy; Bolon, Brad; Ferrando, Ronald; Blackmore, Craig; Schroeder, Kurt; Rodriguez, Luis A; Hristopoulos, Maria; Venook, Rayna; Ashkenazi, Avi; Desnoyers, Luc R

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt Science Signaling, 2012, ISSN: 1937-9145

Lin, Kui; Lin, Jie; Wu, Wen-I; Ballard, Joshua; Lee, Brian B.; Gloor, Susan L.; Vigers, Guy P. A.; Morales, Tony H.; Friedman, Lori S.; Skelton, Nicholas; Brandhuber, Barbara J. ;

Bevacizumab in Combination With Chemotherapy as First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Cutsem, Eric Van; Haas, Sanne de; Kang, Yoon-Koo; Ohtsu, Atsushi; Tebbutt, Niall C; Xu, Jian Ming; Yong, Wei Peng; Langer, Bernd; Delmar, Paul; Scherer, Stefan J; Shah, Manish A;

Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Sun, Yonglian; Senger, Kate; Baginski, Tomasz K; Mazloom, Anita; Chinn, Yvonne; Pantua, Homer; Hamidzadeh, Kajal; Ramani, Sree Ranjani; Luis, Elizabeth; Tom, Irene; Sebrell, Andrew; Quinones, Gabriel; Ma, Yan; Mukhyala, Kiran; Sai, Tao; Ding, Jiabing; Haley, Benjamin; Shadnia, Hooman; Kapadia, Sharookh B; Gonzalez, Lino C; Hass, Philip E; Zarrin, Ali A

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes PLoS ONE, 2012, ISSN: 1932-6203

Wallin, Jeffrey J; Guan, Jane; Edgar, Kyle A; Zhou, Wei; Francis, Ross; Torres, Anthony C; Haverty, Peter M; Eastham-Anderson, Jeffrey; Arena, Sabrina; Bardelli, Alberto; Griffin, Sue; Goodall, John E; Grimshaw, Kyla M; Hoeflich, Klaus P; Torrance, Christopher; Belvin, Marcia; Friedman, Lori S

Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis Current Opinion in Genetics & Development, 2012, ISSN: 0959-437X

Yauch, Robert L; Settleman, Jeff

Translation levels control multi-spanning membrane protein expression PLoS ONE, 2012, ISSN: 1932-6203

Kim, Hok Seon; Ernst, James A; Brown, Cecilia; Bostrom, Jenny; Fuh, Germaine; Lee, Chingwei V; Huang, Arthur; Vandlen, Richard L; Yansura, Daniel G

OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Aghajanian, Carol; Blank, Stephanie V; Goff, Barbara A; Judson, Patricia L; Teneriello, Michael G; Husain, Amreen; Sovak, Mika A; Yi, Jing; Nycum, Lawrence R;

Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis Developmental Cell, 2012, ISSN: 1534-5807

Fong, Abraham P; Yao, Zizhen; Zhong, Jun Wen; Cao, Yi; Ruzzo, Walter L; Gentleman, Robert C; Tapscott, Stephen J;

Inhibiting alternative pathway complement activation by targeting the factor D exosite Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Katschke Jr, Kenneth J; Wu, Ping; Ganesan, Rajkumar; Kelley, Robert F; Mathieu, Mary A; Hass, Philip E; Murray, Jeremy; Kirchhofer, Daniel; Wiesmann, Christian; Campagne, Menno van Lookeren;

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R Structure, 2012, ISSN: 0969-2126

Ma, Xiaolei; Lin, Wei Yu; Chen, Yongmei; Stawicki, Scott; Mukhyala, Kiran; Wu, Yan; Martin, Flavius; Bazan, J. Fernando; Starovasnik, Melissa A;

Cancer: Clinical trials unite mice and humans Nature, 2012, ISSN: 0028-0836

Johnson, Leisa;

Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors Science Signaling, 2012, ISSN: 1945-0877

Varfolomeev, Eugene; Goncharov, Tatiana; Maecker, Heather; Zobel, Kerry; Kömüves, László G; Deshayes, Kurt; Vucic, Domagoj;

Small-Molecule Ligands Bind to a Distinct Pocket in Ras and Inhibit SOS-Mediated Nucleotide Exchange Activity Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Fang, Guowei; Wang, Weiru; Rudolph, Joachim; Jackson, Peter K.; Mellman, Ira; Starovasnik, Melissa A.; Giannetti, Anthony M.; Wu, Jiansheng; Bowman, Krista K.; Ludlam, Mary J. C.; Stokoe, David; Malek, Shiva; Pan, Borlan; Fauber, Benjamin P.; Skelton, Nicholas J.; Anderson, Daniel J.; Pitts, Keith; Oh, Angela; Garrenton, Lindsay S.; Maurer, Till

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Grogan, Jane L.; Eaton, Dan L.; Bazan, J. Fernando; Wiesmann, Christian; Comps-Agrar, Laëtitia; Yin, Jianping; Rouge, Lionel; Yu, Xin; Harden-Bowles, Kristin; Stengel, Katharina F.

Drug-Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug-Drug Interaction Prediction Pharmaceutical Research, 2012, ISSN: 0724-8741

Kenny, Jane R; Mukadam, Sophie; Zhang, Chenghong; Tay, Suzanne; Collins, Carol; Galetin, Aleksandra; Khojasteh, S. Cyrus;

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Flygare, John A; Beresini, Maureen; Budha, Nageshwar; Chan, Helen; Chan, Iris T; Cheeti, Sravanthi; Cohen, Frederick; Deshayes, Kurt; Doerner, Karl; Eckhardt, S. Gail; Elliott, Linda O; Feng, Bainian; Franklin, Matthew C; Reisner, Stacy Frankovitz; Gazzard, Lewis; Halladay, Jason; Hymowitz, Sarah G; La, Hank; LoRusso, Patricia; Maurer, Brigitte; Murray, Lesley; Plise, Emile; Quan, Clifford; Stephan, Jean-Philippe; Young, Shin G; Tom, Jeffrey; Tsui, Vickie; Um, Joanne; Varfolomeev, Eugene; Vucic, Domagoj; Wagner, Andrew J; Wallweber, Heidi J. A; Wang, Lan; Ware, Joseph; Wen, Zhaoyang; Wong, Harvey; Wong, Jonathan M; Wong, Melisa; Wong, Susan; Yu, Ron; Zobel, Kerry; Fairbrother, Wayne J;

In Vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease PLoS ONE, 2012,

Chiang, Eugene Y; Kolumam, Ganesh; McCutcheon, Krista M; Young, Judy; Lin, Zhonghua; Balazs, Mercedesz; Grogan, Jane L;

Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses Pharmaceutical Research, 2012, ISSN: 0724-8741

Abbas, Shermeen A; Sharma, Vikas K; Patapoff, Thomas W; Kalonia, Devendra S;

Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells PLoS Pathogens, 2012, ISSN: 1553-7366

Smed-Sörensen, Anna; Chalouni, Cécile; Chatterjee, Bithi; Cohn, Lillian; Blattmann, Peter; Nakamura, Norihiro; Delamarre, Lélia; Mellman, Ira;

An evolutionary conserved PILRα domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Sun, Yonglian; Senger, Kate; Baginski, Tomasz K; Mazloom, Anita; Chinn, Yvonne; Pantua, Homer; Hamidzadeh , Kajal; Ramani, Sree Ranjani; Luis, Elizabeth; Tom, Irene; Sebrell, Andrew; Quinones, Gabriel; Ma, Yan; Mukhyala, Kiran; Sai, Tao; Ding, Jiabing; Haley, Benjamin; Shadnia, Hooman; Kapadia, Sharookh B; Gonzalez, Lino C; Hass, Philip E; Zarrin, Ali A;

Engineering upper hinge improves stability and effector function of a human IgG1 Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Yan, Boxu; Boyd, Daniel; Kaschak, Timothy; Tsukuda, Joni; Shen, Amy; Lin, Yuwen; Chung, Shan; Gupta, Priyanka; Kamath, Amrita; Wong, Anne; Vernes, Jean-Michel; Meng, Gloria Y.; Totpal, Klara; Schaefer, Gabriele; Jiang, Guoying; Nogal, Bartek; Emery, Craig; Vanderlaan, Martin; Carter, Paul; Harris, Reed; Amanullah, Ashraf

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo PloS ONE, 2012,

Cleopatra Kozlowski ; Robby M Weimer

IgE(+) memory B cells and plasma cells generated through a germinal-center pathway Nature Immunology, 2012, ISSN: 1529-2908

Talay, Oezcan; Yan, Donghong; Brightbill, Hans D; Straney, Elizabeth E M; Zhou, Meijuan; Ladi, Ena; Lee, Wyne P; Egen, Jackson G; Austin, Cary D; Xu, Min; Wu, Lawren C

Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Mathieu, Simon; Gradl, Stefan N; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W; Buckmelter, Alex J; Choo, Edna F; Dinkel, Victoria; Gloor, Susan L; Gould, Stephen E; Hansen, Joshua D; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R; Moreno, David; Ran, Yingqing; Voegtli, Walter C; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim;

Death Receptors DR6 and TROY Regulate Brain Vascular Development Developmental cell, 2012, ISSN: 1534-5807

Tam, Stephen J; Richmond, David L; Kaminker, Joshua S; Modrusan, Zora; Martin-McNulty, Baby; Cao, Tim C; Weimer, Robby M; Carano, Richard A D; van Bruggen, Nick; Watts, Ryan J

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling Nature Immunology, 2012, ISSN: 1529-2908

Seiler, Michael P.; Mathew, Rebecca; Liszewski, Megan K.; Spooner, Chauncey; Barr, Kenneth; Meng, Fanyong; Singh, Harinder; Bendelac, Albert

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells Development, 2012, ISSN: 0950-1991

VanDussen, Kelli L.; Carulli, Alexis J.; Keeley, Theresa M.; Dempsey, Peter J.; Samuelson, Linda C.; Patel, Sanjeevkumar R.; Maillard, Ivan; Puthoff, Brent J.; Magness, Scott T.; Tran, Ivy T.; Kolterud, Åsa; Grosse, Ann S.; Gumucio, Deborah L.; Ernst, Stephen A.; Siebel, Christian; Tsai, Yu-Hwai

Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Owens III, A. Phillip; Antoniak, Silvio; Williams, Julie C.; Wang, Jianguo; Mackman, Nigel; Passam, Freda H.; Furie, Barbara C.; Furie, Bruce; Marshall, Stephanie M.; McDaniel, Allison L.; Rudel, Lawrence; Temel, Ryan E.; Hubbard, Brian K.; Johns, Douglas G.; Dutton, Julie-Ann; Moriarty, Patrick M.; Tobias, Peter S.; Curtiss, Linda K.; Daugherty, Alan; Kirchhofer, Daniel; Luyendyk, James P.; Nagarajan, Shanmugam

High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency PLoS Genetics, 2012, ISSN: 1553-7390

Ferreira, Ricardo C; Pan-Hammarström, Qiang; Graham, Robert R; Fontán, Gumersindo; Lee, Annette T; Ortmann, Ward; Wang, Ning; Urcelay, Elena; Fernández-Arquero, Miguel; Núñez, Concepción; Jorgensen, Gudmundur; Ludviksson, Björn R; Koskinen, Sinikka; Haimila, Katri; Padyukov, Leonid; Gregersen, Peter K; Hammarström, Lennart; Behrens, Timothy W

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates Nature Biotechnology, 2012, ISSN: 1087-0156

Shen, Ben-Quan; Xu, Keyang; Liu, Luna; Raab, Helga; Bhakta, Sunil; Kenrick, Margaret; Parsons-Reponte, Kathryn L; Tien, Janet; Yu, Shang-Fan; Mai, Elaine; Li, Dongwei; Tibbitts, Jay; Baudys, Jakub; Saad, Ola M; Scales, Suzie J; McDonald, Paul J; Hass, Philip E; Eigenbrot, Charles; Nguyen, Trung; Solis, Willy A; Fuji, Reina N; Flagella, Kelly M; Patel, Darshana; Spencer, Susan D; Khawli, Leslie A; Ebens, Allen; Wong, Wai Lee; Vandlen, Richard; Kaur, Surinder; Sliwkowski, Mark X; Scheller, Richard H; Polakis, Paul; Junutula, Jagath R

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer Nature Medicine, 2012, ISSN: 1078-8956

Montagut, Clara; Dalmases, Alba; Gallen, Manuel; Bellmunt, Joaquim; Rovira, Ana; Albanell, Joan; Bellosillo, Beatriz; Pairet, Silvia; Serrano, Sergi; Iglesias, Mar; Salido, Marta; Crespo, Marta; Bosch, Francesc; Marsters, Scot; Tsai, Siao Ping; Somasekar, Seshagiri; Settleman, Jeff; Minoche, André; Himmelbauer, Heinz

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation Nature Immunology, 2012, ISSN: 1529-2908

Ochiai, Kyoko; Maienschein-Cline, Mark; Mandal, Malay; Triggs, Joseph R.; Bertolino, Eric; Sciammas, Roger; Dinner, Aaron R.; Clark, Marcus R.; Singh, Harinder

Antibody-mediated Inhibition of Fibroblast Growth Factor-19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys Toxicological Sciences, 2012, ISSN: 1096-0929

Pai, Rama; French, Dorothy; Ma, Ning; Hotzel, Kathy; Plise, Emile; Salphati, Laurent; Setchell, Kenneth D R; Ware, Joseph; Lauriault, Veronique; Leah, Schutt; Hartley, Dylan; Dambach, Donna

Protecting Group Free, Stereocontrolled Synthesis of beta-Halo-enamides Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Pasqua, Adele E; Crawford, James J; Long, De-Liang; Marquez, Rodolfo;

Signaling: An oxysterol ligand for Smoothened Nature Chemical Biology, 2012, ISSN: 1552-4450

Sharpe, Hayley J.; De Sauvage, Frederic J.

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy Developmental Cell, 2012, ISSN: 1534-5807

Geng, Linda N.; Snider, Lauren; Fong, Abraham P.; Cech, Jennifer N.; Young, Janet M.; Tapscott, Stephen J.; Yao, Zizhen; vanderMaarel, Silvere M.; Ruzzo, Walter L.; Gentleman, Robert C.; Tawil, Rabi

Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural & Molecular Biology, 2012, ISSN: 1545-9985

Huang, Oscar W; Ma, Xiaolei; Yin, Jianping; Flinders, Jeremy; Maurer, Till; Kayagaki, Nobuhiko; Phung, Qui; Bosanac, Ivan; Arnott, David; Dixit, Vishva M; Hymowitz, Sarah G; Starovasnik, Melissa A; Cochran, Andrea G

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C PLoS ONE, 2012, ISSN: 1932-6203

Mintzer, Robert; Ramaswamy, Sreemathy; Shah, Kinjalkumar; Hannoush, Rami N; Pozniak, Christine D; Cohen, Frederick; Zhao, Xianrui; Plise, Emile; Lewcock, Joseph W; Heise, Christopher E

Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis Science, 6 Jan 2012, v335(6064), p89-92, ISSN: 0036-8075, eISSN: 1095-9203

Hsu, Chia-Lin; Lin, Weiyu; Seshasayee, Dhaya; Chen, Yung-Hsiang; Ding, Xiao; Lin, Zhonghua; Suto, Eric; Huang, Zhiyu; Lee, Wyne P; Park, Hyunjoo; Xu, Min; Sun, Mei; Rangell, Linda; Lutman, Jeff L; Ulufatu, Sheila; Stefanich, Eric; Chalouni, Cecile; Sagolla, Meredith; Diehl, Lauri; Fielder, Paul; Dean, Brian; Balazs, Mercedesz; Martin, Flavius

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain Nature Cell Biology, 2012, ISSN: 1465-7392

Chih, Ben; Peterson, Andrew S.; Liu, Peter; Chinn, Yvonne; Hass, Philip E.; Sandoval, Wendy; Chalouni, Cecile; Komuves, Laszlo G.

Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury Nature Medicine, 2012, ISSN: 1078-8956

Ertürk, Ali

The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly Cell, 26 Dec 2011, v147(6), p1309-23, ISSN: 0092-8674

Torres, Jorge Z; Summers, Matthew K; Peterson, David; Brauer, Matthew J; Lee, James; Senese, Silvia; Gholkar, Ankur A; Lo, Yu-Chen; Lei, Xingye; Jung, Kenneth; Anderson, David C; Davis, David P; Belmont, Lisa; Jackson, Peter K

The A-MYSM Power of Deubiquitinases Immunity, 23 Dec 2011, v35(6), p847-849, ISSN: 1074-7613

Demarco, Ignacio A.; Singh, Harinder

Cancer immunotherapy comes of age Nature, 21 Dec 2011, v480, p480-489, ISSN: 1476-4687

Mellman, Ira; Coukos, George; Dranoff, Glenn

Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 Science Translational Medicine, 2011, ISSN: 1946-6234

Wu AL; Kolumam G; Stawicki S; Chen Y; Li J; Zavala-Solorio J; Phamluong K; Feng B; Li L; Marsters S; Kates L; van Bruggen N; Leabman M; Wong A; West D; Stern H; Luis E; Kim HS; Yansura D; Peterson AS; Filvaroff E; Wu Y; Sonoda J

Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition PLoS ONE, 2011, ISSN: 1932-6203

Shankar, Jata; Clemons, Karl V.; Monteiro, Jomar P.; Mirels, Laurence F.; Stevens, David A.; Wu, Thomas D.

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 Cancer Cell, 2011, ISSN: 1535-6108

Junttila, Teemu T.; Akita, Robert W.; Parsons, Kathryn; Fields, Carter; Lewis Phillips, Gail D.; Friedman, Lori S.; Sampath, Deepak; Sliwkowski, Mark X.

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap PLoS Genetics, 2011, ISSN: 1553-7390

Ramos, Paula S.; Criswell, Lindsey A.; Chung, Sharon A.; Moser, Kathy L.; Kelly, Jennifer A.; Gaffney, Patrick M.; Alarcón-Riquelme, Marta E.; Comeau, Mary E.; Williams, Adrienne H.; Pajewski, Nicholas M.; Langefeld, Carl D.; Graham, Robert R.; Zidovetzki, Raphael; Kaufman, Kenneth M.; Harley, John B.; Jacob, Chaim O.; Vyse, Timothy J.; Tsao, Betty P.; Kimberly, Robert P.

Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation Journal of Biological Chemistry, v286(48), p41852-41861, ISSN: 0021-9258

Mao, Yifan; Shang, Yonglei; Zha, Jiping; Pham, Victoria C.; Ernst, James A.; Lill, Jennie R.; Scales, Suzie J.

BEAM: A Randomized Phase II Study Evaluating the Activity of Bevacizumab in Combination With Carboplatin Plus Paclitaxel in Patients With Previously Untreated Advanced Melanoma Journal of Clinical Oncology, 28 Nov 2011, ISSN: 1527-7755.

Kim, Kevin B; Sosman, Jeffrey A; Fruehauf, John P; Linette, Gerald P; Markovic, Svetomir N; McDermott, David F; Weber, Jeffrey S; Nguyen, Hoa; Cheverton, Peter; Chen, Daniel; Peterson, Amy C; Carson, William E 3rd; O, Day Steven J

Rational Design of Phosphoinositide 3-Kinase alpha Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase beta Isoform Journal of Medicinal Chemistry, 24 Nov 2011, vol. 54, no. 22, p. 7815-33, ISSN: 1520-4804

Heffron, Timothy P; Wei, Binqing; Olivero, Alan; Staben, Steven T; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing Yan

Lymphangiogenesis is required for pancreatic islet inflammation and diabetes PLoS One, 23 Nov 2011, v6(11), pe28023, ISSN: 1932-6203

Yin, Na; Lal, Girdhari; Xu, Jiangnan; Ding, Yaozhong; Bromberg, Jonathan S.; Zhang, Nan; Yan, Minhong

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial The Lancet, 19 Nov 2011, V378, N9805, pp 1779-1787, ISSN: 0140-6736

Kappos, Ludwig; Li, David; Calabresi, Peter A; O, Connor Paul; Bar, Or Amit; Barkhof, Frederik; Yin, Ming; Leppert, David; Glanzman, Robert; Tinbergen, Jeroen; Hauser, Stephen L

It takes two to tango: a new couple in the family of ubiquitin-editing complexes Nature Immunology, 16 Nov 2011, vol.12, no.12, p.1133-5, ISSN: 1529-2916

Wertz, Ingrid E

The heart endocardium is derived from vascular endothelial progenitors. Development, 1 Nov 2011, V138, N21, pp 4777-4787. ISSN: 0950-1991.

Milgrom, Hoffman Michal; Harrelson, Zachary; Ferrara, Napoleone; Zelzer, Elazar; Evans, Sylvia M; Tzahor, Eldad

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q. PloS one, {PLoS-ONE}, 2011 (epub: 12 Oct 2011), vol. 6, no. 10, p. e25038, ISSN: 1932-6203.

Pidasheva, Svetlana; Trifari, Sara; Phillips, Anne; Hackney, Jason A; Ma, Yan; Smith, Ashley; Sohn, Sue J; Spits, Hergen; Little, Randall D; Behrens, Timothy W; Honigberg, Lee; Ghilardi, Nico; Clark, Hilary F

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin. Journal of Clinical Oncology, 24 Oct 2011, ISSN: 1527-7755.

Lai, Albert; Kharbanda, Samir; Pope, Whitney B; Tran, Anh; Solis, Orestes E; Peale, Franklin; Forrest, William F; Pujara, Kanan; Carrillo, Jose A; Pandita, Ajay; Ellingson, Benjamin M; Bowers, Chauncey W; Soriano, Robert H; Schmidt, Nils O; Mohan, Sankar; Yong, William H; Seshagiri, Somasekar; Modrusan, Zora; Jiang, Zhaoshi; Aldape, Kenneth D; Mischel, Paul S; Liau, Linda M; Escovedo, Cameron J; Chen, Weidong; Nghiemphu, Phioanh Leia; James, C David; Prados, Michael D; Westphal, Manfred; Lamszus, Katrin; Cloughesy, Timothy; Phillips, Heidi S

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 21 Oct 2011, vol. 334, no. 6054, p. 376-80, ISSN: 1095-9203.

Dueber, Erin C; Schoeffler, Allyn J; Lingel, Andreas; Elliott, J Michael; Fedorova, Anna V; Giannetti, Anthony M; Zobel, Kerry; Maurer, Brigitte; Varfolomeev, Eugene; Wu, Ping; Wallweber, Heidi J A; Hymowitz, Sarah G; Deshayes, Kurt; Vucic, Domagoj; Fairbrother, Wayne J

Impaired FcepsilonRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins Blood, 20 October 2011, vol. 118, no. 16, p. 4377-4383, eISSN: 1528-0020, ISSN: 0006-4971.

Hazenbos, Wouter L W; Wu, Ping; Eastham, Anderson Jeffrey; Kinoshita, Taroh; Brown, Eric J

A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies Cancer Cell, 18 Oct 2011, v20(4), p.472-86, ISSN: 1878-3686

Gabriele Schaefer; Lauric Haber; Lisa M. Crocker; Steven Shia; Lily Shao; Donald Dowbenko; Klara Totpal; Anne Wong; Chingwwei V. Lee; Scott Stawicki; Robyn Clark; Carter Fields; Gail D. Lewis Phillips; Rodney A. Prell; Dimitry M. Danilenko; Yvonne Franke; Jean-Philippe Stephan; Jiyoung Hwang; Yan Wu; Jenny Bostrom, Mark X. Sliwkowski; Germaine Fuh; Charles Eigenbrot

Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non-Small-Cell Lung Cancer. Journal of Clinical Oncology, 17 Oct 2011, ISSN: 1527-7755.

Soria, Jean Charles; Mark, Zsuzsanna; Zatloukal, Petr; Szima, Barna; Albert, Istvan; Juhasz, Erzsebet; Pujol, Jean Louis; Kozielski, Jerzy; Baker, Nigel; Smethurst, Dominic; Hei, Yong Jiang; Ashkenazi, Avi; Stern, Howard; Amler, Lukas; Pan, Yang; Blackhall, Fiona

Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry Analytical Chemistry, Oct 17, 2011, vol. 83, no. 22, p. 8501-8, ISSN: 1520-6882.

Zhang, Liangyi; Lilyestrom, Wayne; Li, Charlene; Scherer, Thomas; van, Reis Robert; Zhang, Boyan

Non-canonical inflammasome activation targets caspase-11. Nature, 16 Oct 2011, ISSN: 1476-4687.

Kayagaki, Nobuhiko; Warming, Soeren; Lamkanfi, Mohamed; Walle, Lieselotte Vande; Louie, Salina; Dong, Jennifer; Newton, Kim; Qu, Yan; Liu, Jinfeng; Heldens, Sherry; Zhang, Juan; Lee, Wyne P; Roose, Girma Merone; Dixit, Vishva M

Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. Nature immunology, 16 Oct 2011, ISSN: 1529-2916.

Rutz, Sascha; Noubade, Rajkumar; Eidenschenk, Celine; Ota, Naruhisa; Zeng, Wenwen; Zheng, Yan; Hackney, Jason; Ding, Jiabing; Singh, Harinder; Ouyang, Wenjun

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells Nature Immunology, 2011, ISSN: 0022-1767

Rutz, Sascha; Noubade, Rajkumar; Eidenschenk, Celine; Singh, Harinder; Ouyang, Wenjun

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL. Cancer Cell, 2011, V20, N3, SEP 13, pp 357-369. ISSN: 1535-6108.

Mali, Raghuveer Singh; Ramdas, Baskar; Ma, Peilin; Shi, Jianjian; Munugalavadla, Veerendra; Sims, Emily; Wei, Lei; Vemula, Sasidhar; Nabinger, Sarah C; Goodwin, Charles B; Chan, Rebecca J; Traina, Fabiola; Visconte, Valeria; Tiu, Ramon V; Lewis, Timothy A; Stern, Andrew M; Wen, Qiang; Crispino, John D; Boswell, H Scott; Kapur, Reuben

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nature Immunology, 12 Oct 2011, ISSN: 1529-2916.

Ramirez, Carrozzi Vladimir; Sambandam, Arivazhagan; Luis, Elizabeth; Lin, Zhongua; Jeet, Surinder; Lesch, Justin; Hackney, Jason; Kim, Janice; Zhou, Meijuan; Lai, Joyce; Modrusan, Zora; Sai, Tao; Lee, Wyne; Xu, Min; Caplazi, Patrick; Diehl, Lauri; de Voss, Jason; Balazs, Mercedesz; Gonzalez, Lino Jr; Singh, Harinder; Ouyang, Wenjun; Pappu, Rajita

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (m TOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer Journal of Medicinal Chemistry, 7 Oct 2011, ISSN: 1520-4804.

Sutherlin, Daniel P; Bao, Linda; Berry, Megan; Castanedo, Georgette; Chuckowree, Irina; Dotson, Jenna; Folks, Adrian; Friedman, Lori; Goldsmith, Richard; Gunzner, Janet; Heffron, Timothy; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Murray, Jeremy; Nonomiya, Jim; Pang, Jodie; Pegg, Niel; Prior, Wei Wei; Rouge, Lionel; Salphati, Laurent; Sampath, Deepak; Tian, Qingping; Tsui, Vickie; Wan, Nan Chi; Wang, Shumei; Wei, Binqing; Wiesmann, Christian; Wu, Ping; Zhu, Bing Yan; Olivero, Alan

Phosphorous Dysregulation Induced by MEK Small Molecule Inhibitors in the Rat Involves Blockade of FGF-23 Signaling in the Kidney. Toxicological Sciences, 5 Oct 2011, ISSN: 1096-0929.

Diaz, Dolores; Allamneni, Krishna; Tarrant, Jaqueline M; Lewin, Koh Sock C; Pai, Rama; Dhawan, Preeti; Cain, Gary R; Kozlowski, Cleopatra; Hiraragi, Hajime; La, Nghi; Hartley, Dylan P; Ding, Xiao; Dean, Brian J; Bheddah, Sheila; Dambach, Donna M

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood, 2011, V118, N13, SEP 29, pp 3459-3469. ISSN: 0006-4971.

Ma, Peilin; Mali, Raghuveer Singh; Munugalavadla, Veerendra; Krishnan, Subha; Ramdas, Baskar; Sims, Emily; Martin, Holly; Ghosh, Joydeep; Li, Shuo; Chan, Rebecca J; Krystal, Gerald; Craig, Andrew W; Takemoto, Clifford; Kapur, Reuben

A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proceedings of the National Academy of Sciences, 26 Sep 2011, ISSN: 1091-6490.

Dompe, Nicholas; Rivers, Celina Sanchez; Li, Li; Cordes, Shaun; Schwickart, Martin; Punnoose, Elizabeth A; Amler, Lukas; Seshagiri, Somasekar; Tang, Jerry; Modrusan, Zora; Davis, David P

A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis. Science Translational Medicine, 21 Sep 2011, vol. 3, no. 101, p. 101ra92, ISSN: 1946-6234, eISSN: 1946-6242.

Owczarczyk, Kasia; Lal, Preeti; Abbas, Alexander R; Wolslegel, Kristen; Holweg, Cecile T J; Dummer, Wolfgang; Kelman, Ariella; Brunetta, Paul; Lewin, Koh Nicholas; Sorani, Marco; Leong, Diane; Fielder, Paul; Yocum, David; Ho, Carole; Ortmann, Ward; Townsend, Michael J; Behrens, Timothy W

Wnt Antagonists Bind through a Short Peptide to the First beta-Propeller Domain of LRP5/6. Structure, 21 Sep 2011, ISSN: 1878-4186.

Bourhis, Eric; Wang, Weiru; Tam, Christine; Hwang, Jiyoung; Zhang, Yingnan; Spittler, Didier; Huang, Oscar W; Gong, Yan; Estevez, Alberto; Zilberleyb, Inna; Rouge, Lionel; Chiu, Cecilia; Wu, Yan; Costa, Mike; Hannoush, Rami N; Franke, Yvonne; Cochran, Andrea G

A secreted protein microarray platform for extracellular protein interaction discovery. Analytical Biochemistry, 21 Sep 2011, ISSN: 1096-0309.

Ramani, Sree R; Tom, Irene; Lewin, Koh Nicholas; Wranik, Bernd; Depalatis, Laura; Zhang, Jianjun; Eaton, Dan; Gonzalez, Lino C

A reserve stem cell population in small intestine renders Lgr5- positive cells dispensable. Nature, 18 Sep 2011, ISSN: 1476-4687.

Tian, Hua; Biehs, Brian; Warming, Soeren; Leong, Kevin G; Rangell, Linda; Klein, Ophir D; de Sauvage, Frederic J

USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma. Cell, 16 Sep 2011, vol. 146, no. 6, p. 918-30, ISSN: 1097-4172.

Williams, Samuel A; Maecker, Heather L; French, Dorothy M; Liu, Jinfeng; Gregg, Andrew; Silverstein, Leah B; Cao, Tim C; Carano, Richard A D; Dixit, Vishva M

Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition. Chemical Research in Toxicology, 9 Sep 2011, ISSN: 1520-5010.

Zhang, Chenghong; Kenny, Jane R; Le, Hoa; Deese, Alan; Ford, Kevin A; Lightning, Luke K; Fan, Peter W; Driscoll, James P; Halladay, Jason S; Hop, Cornelis E C A; Khojasteh, S Cyrus

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. Journal of Cell Biology, 5 Sep 2011, v194, n5, p751-64, ISSN: 1540-8140.

Sengupta, Ghosh Arundhati; Wang, Bei; Pozniak, Christine D; Chen, Mark; Watts, Ryan J; Lewcock, Joseph W

A20 edits ubiquitin and autoimmune paradigms. Nature genetics, 1 August 2011, vol. 43, no. 9, p. 822-3, ISSN: 1546-1718.

Martin, Flavius; Dixit, Vishva M

Lyp breakdown and autoimmunity Nature Genetics, 29 August 2011, vol. 43, no. 9, p. 821-2, ISSN: 1546-1718.

Behrens, Timothy W

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium Nature Immunology, 28 Aug 2011 (epub: 28 8 2011), ISSN: 1529-2916.

Ota, Naruhisa; Wong, Kit; Valdez, Patricia A; Zheng, Yan; Crellin, Natasha K; Diehl, Lauri; Ouyang, Wenjun

Regulation of interleukin-10 and interleukin-22 expression in T helper cells Current Opinion in Immunology, 20 Aug 2011, ISSN: 1879-0372.

Rutz, Sascha; Ouyang, Wenjun

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers Cancer Cell, 16 Aug 2011, vol. 20, no. 2, p. 158-72, ISSN: 1878-3686.

Wilson, Timothy R; Lee, Diana Y; Berry, Leanne; Shames, David S; Settleman, Jeff

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. Journal of Experimental Medicine, 2011, V208, 9, pp 1777-1787. ISSN: 0022-1007, eISSN: 1540-9538

Foger, Niko; Jencke, André; Orinska, Zane; Lee, Kyeong-Hee; Chan, Andrew; Bulfone-Paus, Silvia

Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield Structure, 10 Aug 2011, vol. 19, no. 8, p. 1053-63, ISSN: 1878-4186.

Dong, Ken C; Helgason, Elizabeth; Yu, Christine; Phu, Lilian; Arnott, David P; Bosanac, Ivan; Compaan, Deanne M; Huang, Oscar W; Fedorova, Anna V; Kirkpatrick, Donald S; Hymowitz, Sarah G; Dueber, Erin C

Pervasive Sharing of Genetic Effects in Autoimmune Disease. PLoS Genetics, 10 AUG 2011, V7, N8, ISSN: 1553-7390.

Cotsapas, Chris; Voight, Benjamin F; Rossin, Elizabeth; Lage, Kasper; Neale, Benjamin M; Wallace, Chris; Abecasis, Goncalo R; Barrett, Jeffrey C; Behrens, Timothy; Cho, Judy; De Jager, Philip L; Elder, James T; Graham, Robert R; Gregersen, Peter; Klareskog, Lars; Siminovitch, Katherine A; van, Heel David A; Wijmenga, Cisca; Worthington, Jane; Todd, John A; Hafler, David A; Rich, Stephen S; Daly, Mark J

miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer Science signaling, 16 Aug 2011, vol. 4, no. 186, p. pt5, ISSN: 1937-9145.

Stinson, Susanna; Lackner, Mark R; Adai, Alex T; Yu, Nancy; Kim, Hyo Jin; O, Brien Carol; Spoerke, Jill; Jhunjhunwala, Suchit; Boyd, Zachary; Januario, Thomas; Newman, Robert J; Yue, Peng; Bourgon, Richard; Modrusan, Zora; Stern, Howard M; Warming, Soeren; de Sauvage, Frederic J; Amler, Lukas; Yeh, Ru Fang; Dornan, David

Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics PloS One, 2011 (epub: 04 Aug 2011), vol. 6, no. 8, p. e22607, ISSN: 1932-6203.

Anderson, Daniel J; Durieux, Jenni K; Song, Kyung; Alvarado, Ryan; Jackson, Peter K; Hatzivassiliou, Georgia; Ludlam, Mary J C

Lebrikizumab Treatment in Adults with Asthma The New England journal of medicine, {N-Engl-J-Med}, 3 Aug 2011 (epub: 3 8 2011), ISSN: 1533-4406.

Corren, Jonathan; Lemanske, Robert F; Hanania, Nicola A; Korenblat, Phillip E; Parsey, Merdad V; Arron, Joseph R; Harris, Jeffrey M; Scheerens, Heleen; Wu, Lawren C; Su, Zheng; Mosesova, Sofia; Eisner, Mark D; Bohen, Sean P; Matthews, John G

Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

Abbas, Alexander R; Jackman, Janet K; Bullens, Sherron L; Davis, Sarah M; Choy, David F; Fedorowicz, Grazyna; Tan, Martha; Truong, Bao Tran; Gloria, Meng Y; Diehl, Lauri; Miller, Lisa A; Schelegle, Edward S; Hyde, Dallas M; Clark, Hilary F; Modrusan, Zora; Arron, Joseph R; Wu, Lawren C

Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody Pharmaceutical Research, {Pharm-Res}, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1573-904X.

Sreedhara, Alavattam; Cordoba, Armando; Zhu, Qing; Kwong, Jeanne; Liu, Jun

On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format. Analytical Biochemistry, 2 Aug 2011, ISSN: 1096-0309.

Alvarez, Melissa; Tremintin, Guillaume; Wang, Jennifer; Eng, Marian; Kao, Yung Hsiang; Jeong, Justin; Ling, Victor T; Borisov, Oleg V

Genetic Analyses of Interferon Pathway-Related Genes Reveal Multiple New Loci Associated With Systemic Lupus Erythematosus. Arthritis & Rheumatism, 2011, V63, N7, JUL, pp 2049-2057. ISSN: 0004-3591.

Ramos, Paula S; Williams, Adrienne H; Ziegler, Julie T; Comeau, Mary E; Guy, Richard T; Lessard, Christopher J; Li, He; Edberg, Jeffrey C; Zidovetzki, Raphael; Criswell, Lindsey A; Gaffney, Patrick M; Graham, Deborah Cunninghame; Graham, Robert R; Kelly, Jennifer A; Kaufman, Kenneth M; Brown, Elizabeth E; Alarcon, Graciela S; Petri, Michelle A; Reveille, John D; McGwin, Gerald; Vila, Luis M; Ramsey, Goldman Rosalind; Jacob, Chaim O; Vyse, Timothy J; Tsao, Betty P; Harley, John B; Kimberly, Robert P; Alarcon, Riquelme Marta E; Langefeld, Carl D; Moser, Kathy L

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex The EMBO journal, {EMBO-J}, 19 Jul 2011 (epub: 19 7 2011), ISSN: 1460-2075.

Bentley, Matthew L; Corn, Jacob E; Dong, Ken C; Phung, Qui; Cheung, Tommy K; Cochran, Andrea G

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling PLoS ONE, {PLoS-ONE}, 2011, vol. 6, no. 7, article number: e22595, 35 refs, eISSN: 1932-6203. Publisher: Public Library of Science, 185 Berry Street, Suite 1300, San Francisco, CA 94107, USA.

Callow, Marinella G; Tran, Hoanh; Phu, Lilian; Lau, Ted; Lee, James; Sandoval, Wendy N; Liu, Peter S; Bheddah, Sheila; Tao, Janet; Lill, Jennie R; Hongo, Jo Anne; Davis, David; Kirkpatrick, Donald S; Polakis, Paul; Costa, Mike

Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination BLOOD, 2011, V118, N3, JUL 21, pp 598-608. ISSN: 0006-4971.

Nguyen, Xuan Hung; Lang, Philipp A; Lang, Karl S; Adam, Dieter; Fattakhova, Gulnar; Foeger, Niko; Kamal, Mohammad Azhar; Prilla, Patricia; Mathieu, Sabine; Wagner, Christina; Mak, Tak; Chan, Andrew C; Lee, Kyeong Hee

Preview: A Program for Surveying Shotgun Proteomics Tandem Mass Spectrometry Data. ANALYTICAL CHEMISTRY, 2011, V83, N13, JUL 1, pp 5259-5267. ISSN: 0003-2700.

Kil, Yong J; Becker, Christopher; Sandoval, Wendy; Godberg, David; Bern, Marshall

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Drug metabolism and disposition: the biological fate of chemicals, {Drug-Metab-Dispos}, 8 Jul 2011 (epub: 8 7 2011), ISSN: 1521-009X.

Liu, Lichuan; Halladay, Jason; Shin, Young; Wong, Susan; Coraggio, Melis; La, Hank; Baumgardner, Matthew; Le, Hoa; Gopaul, Sashi; Boggs, Jason; Kuebler, Peter; Davis, John; Liao, Charlene; Lubach, Joseph; Deese, Alan; Sowell, Gregory; Currie, Kevin; Young, Wendy; Khojasteh, Cyrus; Hop, Cornelis; Wong, Harvey

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. NEW ENGLAND JOURNAL OF MEDICINE, 2011, V364, N26, JUN 30, pp 2507-2516. ISSN: 0028-4793.

Chapman, PB; Hauschild, A; Robert, C; Haanen, JB; Ascierto, P; Larkin, J; Dummer, R; Garbe, C; Testori, A; Maio, M; Hogg, D; Lorigan, P; Lebbe, C; Jouary, T; Schadendorf, D; Ribas, A; O'Day, SJ; Sosman, JA; Kirkwood, JM; Eggermont, AM; Dreno, B; Nolop, K; Li, J; Nelson, B; Hou, J; Lee, RJ; Flaherty, KT; McArthur, AG; BRIM-3 Study Group

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development Blood, 2011,

Kyle Niessen; Gu Zhang; John Brady Ridgway; Hao Chen; Ganesh Kolumam; Christian W Siebel; Minhong Yan

Innate immunity: unfolding the neuro-immuno connections. Current biology : CB, {Curr-Biol}, 21 Jun 2011, vol. 21, no. 12, p. R474-6, ISSN: 1879-0445.

Tan, Man Wah

Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map Analysis Analytical Chemistry, 2011, V83, N15, AUG 1, pp 5912-5919. ISSN: 0003-2700.

Yu, X Christopher; Joe, Koman; Zhang, Yu; Adriano, Andrea; Wang, Yaning; Gazzano, Santoro Helene; Keck, Rodney G; Deperalta, Galahad; Ling, Victor

Innate immunity: Unfolding the neuro-immuno connections in resistance and tolerance Current Biology, 2011,

Tan, Man-Wah

TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer. Science Signaling, 2011, ISSN: 1945-0877

Stinson, Susanna; Lackner, Mark R; Adai, Alex T; Yu, Nancy; Kim, Hyo-Jin; O’Brien, Carol; Spoerke, Jill; Jhunjhunwala, Suchit; Boyd, Zachary; Januario, Thomas; Newman, Robert J; Yue, Peng; Bourgon, Richard; Modrusan, Zora; Stern, Howard M; Warming, Søren; de Sauvage, Frederic J; Amler, Lukas; Yeh, Ru-Fang; Dornan, David

VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1. NEURON, 2011, V70, N5, JUN 9, pp 966-978. ISSN: 0896-6273.

de Almodovar, Carmen Ruiz; Fabre, Pierre J; Knevels, Ellen; Coulon, Cathy; Segura, Inmaculada; Haddick, Patrick C G; Aerts, Liesbeth; Delattin, Nicolas; Strasser, Geraldine; Oh, Won Jong; Lange, Christian; Vinckier, Stefan; Haigh, Jody; Fouquet, Coralie; Gu, Chengua; Alitalo, Kari; Castellani, Valerie; Tessier-Lavigne, Marc; Chedotal, Alain; Charron, Frederic; Carmeliet, Peter

Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N21, MAY 27, pp 18969-18981. ISSN: 0021-9258.

Lobito, Adrian A; Ramani, Sree R; Tom, Irene; Bazan, J Fernando; Luis, Elizabeth; Fairbrother, Wayne J; Ouyang, Wenjun; Gonzalez, Lino C

AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3 beta (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N19, MAY 13, pp 16879-16890. ISSN: 0021-9258.

Zhang, Li; Jouret, Francois; Rinehart, Jesse; Sfakianos, Jeff; Mellman, Ira; Lifton, Richard P; Young, Lawrence H; Caplan, Michael J

Rituximab's New Therapeutic Target: The Podocyte Actin Cytoskeleton. Science translational medicine, {Sci-Transl-Med}, 1 Jun 2011, vol. 3, no. 85, p. 85ps21, ISSN: 1946-6242.

Chan, Andrew C

Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation. Pharmaceutical research, {Pharm-Res}, 8 Jun 2011 (epub: 8 6 2011), ISSN: 1573-904X.

Lam, Xanthe M; Lai, William G; Chan, Edwin K; Ling, Victor; Hsu, Chung C

Immunology: In command of commensals. NATURE, 2011, V474, N7349, JUN 2, pp 43-44. ISSN: 0028-0836.

van Lookeren Campagne, Menno; Dixit, Vishva M

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma PLoS ONE, 2011, ISSN: 1932-6203

Lin, K.; Taylor, J.R.; Wu, T.D.; Gutierrez, J.; Elliott, J.M.; Vernes, J.M.; Koeppen, H.; Phillips, H.S.; de Sauvage, F.J.; Meng, Y.G.

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. NATURE, 2011, V474, N7352, JUN 23, pp 511-NIL_141. ISSN: 0028-0836.

Stefater, James A III; Lewkowich, Ian; Rao, Sujata; Mariggi, Giovanni; Carpenter, April C; Burr, Adam R; Fan, Jieqing; Ajima, Rieko; Molkentin, Jeffery D; Williams, Bart O; Wills-Karp, Marsha; Pollard, Jeffrey W; Yamaguchi, Terry; Ferrara, Napoleone; Gerhardt, Holger; Lang, Richard A

Multiple Effects of Angiopoietin-2 Blockade on Tumors. Cancer Cell, 2011, ISSN: 1535-6108

Lewis, C.E.; Ferrara, N.

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. Blood, 2011, ISSN: 0006-4971

Gavins, F.N.E.; Russell, J.; Senchenkova, E.L.; Paula, L.D.A.; Damazo, A.S.; Esmon, C.T.; Kirchhofer, D.; Hebbel, R.P.; Granger, D.N.

High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin is Entropy-Driven in Spite of Structural Plasticity. PloS One, 2011, ISSN: 1932-6203

Bostrom, J.; Haber, L.; Koenig, P.; Kelley, R.F.; Fuh, G.

1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nature Neuroscience, 2011, ISSN: 1097-6256

Jo, J.; Whitcomb, D.J.; Olsen, K.M.; Kerrigan, T.L.; Lo, S.C.; Bru-Mercier, G.; Dickinson, B.; Scullion, S.; Sheng, M.; Collingridge, G.; Cho, K.

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production. PLoS Genetics, 2011, ISSN: 1553-7390

Chung, S.A.; Taylor, K.E.; Graham, R.R.; Nititham, J.; Lee, A.T. Ortmann, W.A.; Jacob, C.O.; Alarcón-Riquelme, M.E.; Tsao, B.P.; Harley, J.B.; Gaffney, P.M.; Moser, K.L.; Petri, M.; Demirci, F.Y.; Kamboh, M.I.; Manzi, S.; Gregersen, P.K.; Langefeld, C.D.; Behrens, T.W.; Criswell, L.A.

Toward Understanding Molecular Heterogeneity of Polysorbates by Application of Liquid Chromatography-Mass Spectrometry with Computer-Aided Data Analysis. Analytical Chemistry, 2011, ISSN: 1520-6882

Borisov, O.V.; Ji, J.A.; Wang, Y.J.; Vega, F.; Ling, V.T.

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry. Molecular Cell, 2011, ISSN: 1097-4164

Huang, X.; Summers, M.K.; Pham, V.; Lill, J.R.; Liu, J.; Lee, G.; Kirkpatrick, D.S.; Jackson, P.K.; Fang, G.; Dixit, V.M.

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons Proceedings Of The National Academy Of Sciences, 2011, ISSN: 0027-8424

Parikh, P.; Hao, Y.; Hosseinkhani, M.; Patil, S.B.; Huntley, G.W.; Tessier-Lavigne, M.; Zou, H.

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells Proceedings of the National Academy of Sciences, 2011, ISSN: 1091-6490

Eastham Anderson, Jeff; Dunlap, Debra; Alicke, Bruno; Nannini, Michelle; Gould, Stephen; Yauch, Robert; Modrusan, Zora; Dupree, Kelly; Darbonne, Walter; de Sauvage, Frederic

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. BLOOD, 2011, V117, N21, MAY 26, pp 5652-5662. ISSN: 0006-4971.

Yao, David; Huang, Yuanshuai; Huang, Xiaoran; Wang, Weihuan; Yan, Quanjian; Wei, Lebing; Xin, Wei; Gerson, Stanton; Stanley, Pamela; Lowe, John B; Zhou, Lan

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target. Science Translational Medicine, 2011, ISSN: 1946-6234

Yu, Y.J.; Zhang, Y.; Kenrick, M.; Hoyte, K.; Luk, W.; Lu, Y.; Atwal, J.; Elliott, J.M.; Prabhu, S.; Watts, R.J.; Dennis, M.S.

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo Science Translational Medicine, 2011, ISSN: 1946-6234

Atwal, J.K.; Chen, Y.; Chiu, C.; Mortensen, D.L.; Meilandt, W.J.; Liu, Y.; Heise, C.E.; Hoyte, K.; Luk, W.; Lu, Y.; Peng, K.; Wu, P.; Rouge, L.; Zhang, Y.; Lazarus, R.A.; Scearce-Levie, K.; Wang, W.; Wu, Y.; Tessier-Lavigne, M.; Watts, R.J.

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry. Drug Metabolism and Disposition, 2011, ISSN: 1521-009X

Graham, R.A.; Lum, B.L.; Morrison, G.; Chang, I.; Jorga, K.; Dean, B.J.;Shin, Y.; Yue, Q.; Mulder, T.; Malhi, V.; Xie, M.; Low, J.; Hop, C.E.

COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature, 2011, ISSN: 0028-0836

Vitari, A.C.; Leong, K.G.; Newton, K.; Yee, C.; O'Rourke, K.; Liu, J.; Phu, L.; Vij, R.; Ferrando, R.; Couto, S.S.; Mohan, S.; Pandita, A.; Hongo, J.A.; Arnott, D.; Wertz, I.E.; Gao, W.Q.; French, D.M.; Dixit, V.M.

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Cell, 2011, ISSN: 1097-4172

Sang, L.; Miller, J.J.; Corbit, K.C.; Giles, R.H.; Brauer, M.J.; Otto, E.A.; Baye, L.M.; Wen, X.; Scales, S.J.; Kwong, M.; Huntzicker, E.G.; Sfakianos, M.K.; Sandoval, W.; Bazan, J.F.; Kulkarni, P.; Garcia-Gonzalo, F.R.; Seol, A.D.; O'Toole, J.F.; Held, S.; Reutter, H.M.; Lane, W.S.; Rafiq, M.A.; Noor, A.; Ansar, M.; Devi, A.R.; Sheffield, V.C.; Slusarski, D.C.; Vincent, J.B.; Doherty, D.A.; Hilde

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Journal of Clinical Investigation, 2011, ISSN: 0021-9738

Sos, B.C.; Harris, C.; Nordstrom, S.M.; Tran, J.L.; Balazs, M.; Caplazi, P.; Febbraio, M.; Applegate, M.A.B.; Wagner, K.U.; Weiss, E.J.

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. Journal of Cell Biology, 2011, ISSN: 0021-9525

Francis, S.S.; Sfakianos, J.; Lo, B.; Mellman, I.

An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia. Blood, 2011, ISSN: 0006-4971

Danese, M.D.; Griffiths, R.I.; Gleeson, M.; Satram-Hoang, S.; Knopf, K.; Joseph, M.; Reyes, C.

Slit2 Activity in the Migration of Guidepost Neurons Shapes Thalamic Projections during Development and Evolution. Neuron, 2011, ISSN: 0896-6273

Bielle, F.; Marcos-Mondejar, P.; Keita, M.; Mailhes, C.; Verney, C.; Ba-Charvet, K.M.; Tessier-Lavigne, M.; Lopez-Bendito, G.; Garel, S.

Do cilia put brakes on the cell cycle? Nature Cell Biology, 2011, ISSN: 1476-4679

Jackson, P.K.

Randomized Phase II Study of Bevacizumab in Combination With Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer: Results From the SALUTE Trial. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Spigel, D.R.; Townley, P.M.; Waterhouse, D.M.; Fang, L.; Adiguzel, I.; Huang, J.E.; Karlin, D.A.; Faoro, L.; Scappaticci, F.A.; Socinski, M.A.

Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine. Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Cohen, F.; Bergeron, P.; Blackwood, E.; Bowman, K.K.; Chen, H.; DiPasquale, A.G.; Epler, J.A.; Koehler, M.F.T.; Lau, K.; Lewis, C.; Liu, L.; Ly, C.Q.; Malek, S.; Nonomiya, J.; Ortwine, D.F.; Pei, Z.; Robarge, K.D.; Sideris, S.; Trinh, L.; Truong, T.; Wu, J.; Zhao, X.; Lyssikatos, J.P.

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences, 2011, ISSN: 1091-6490

Ong, C.C.; Jubb, A.M.; Haverty, P.M.; Zhou, W.; Tran, V.; Truong, T.; Turley, H.; O'Brien, T.; Vucic, D.; Harris, A.L.; Belvin, M.; Friedman, L.S.; Blackwood, E.M.; Koeppen, H.; Hoeflich, K.P.

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Sleebs, B.E.; Czabotar, P.E.; Fairbrother, W.J.; Fairlie, W.D.; Flygare, J.A.; Huang, D.C.S.; Kersten, W.J.A.; Koehler, M.F.T.; Lessene, G.; Lowes, K.; Parisot, J.P.; Smith, B.J.; Smith, M.L.; Souers, A.J.; Street, I.P.; Yang, H.; Baell, J.B.

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Stanford, S.M.; Krishnamurthy, D.; Falk, M.D.; Messina, R.; Debnath, B.; Li, S.; Liu, T.; Kazemi, R.; Dahl, R.; He, Y.; Yu, X.; Chan, A.C.; Zhang, Z.Y.; Barrios, A.M.; Woods, V.L.; Neamati, N.; Bottini, N.

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 2011, ISSN: 1535-6108

Sawey, E.T.; Chanrion, M.; Cai, C.; Wu, G.; Zhang, J.; Zender, L.; Zhao, A.; Busutti, R.W.; Yee, H.; Stein, L.; French, D.M.; Finn, R.S.; Lowe, S.W.; Powers, S.

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2011, ISSN: 0022-1759

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.L.; Meng, Y.G.

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies. PHARMACEUTICAL RESEARCH, 2011, V28, N7, JUL, pp 1750-1764. ISSN: 0724-8741.

Yadav, Sandeep; Sreedhara, Alavattam; Kanai, Sonoko; Liu, Jun; Lien, Samantha; Lowman, Henry; Kalonia, Devendra S; Shire, Steven J

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-alpha Feedforward Signaling Cell, 2011, ISSN: 1097-4172

Biton, Sharon; Ashkenazi, Avi

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime. Analytical Biochemistry, 2011, ISSN: 0003-2697

Yadav, S.; Scherer, T.M.; Shire, S.J.; Kalonia, D.S.

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow. PloS One, 2011, ISSN: 1932-6203

Boswell, C.A.; Ferl, G.Z.; Mundo, E.E.; Bumbaca, D.; Schweiger, M.G.; Theil, F.P.; Fielder, P.J.; Khawli, L.A.

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449). Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Giannetti, Anthony; Wong, Harvey; Dijkgraaf, Gerrit; Dueber, Erin; Bravo, Brandon; Gould, Stephen; Plise, Emile; Lum, Bert; Malhi, Vikram; Graham, Richard; Ortwine, Daniel

RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Robert, N.J.; Dieras, V.; Glaspy, J.; Brufsky, A.M.; Bondarenko, I.; Lipatov, O.N.; Perez, E.A.; Yardley, D.A.; Chan, S.Y.T.; Zhou, X.; Phan, S.C.; O'Shaughnessy, J.

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration. Neuron, 2011, ISSN: 0896-6273

Wang, Y.; Li, G.; Stanco, A.; Long, J.E.; Crawford, D.; Potter, G.B.; Pleasure, S.J.; Behrens, T.; Rubenstein, J.L.R.

Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies. Journal of Immunological Methods, 2011, ISSN: 0022-1759

Ren, D.; Darlucio, M.R.; Chou, J.H.

CD40 Pathway Activation Status Predicts Response to CD40 Therapy in Diffuse Large B Cell Lymphoma. Science Translational Medicine, 2011, ISSN: 1946-6242

Burington, B.; Yue, P.; Shi, X.; Advani, R.; Lau, J.T.; Tan, J.; Stinson, S.; Stinson, J.; Januario, T.; de Vos, S.; Ansell, S.; Forero-Torres, A.; Fedorowicz, G.; Yang, T.T.C.; Elkins, K.; Du, C.; Mohan, S.; Yu, N.; Modrusan, Z.; Seshagiri, S.; Yu, S.F.; Pandita, A.; Koeppen, H.; French, D.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.; Dornan, D.

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways. PloS One, 2011, ISSN: 1932-6203

Wu, A.L.; Coulter, S.; Liddle, C.; Wong, A.; Eastham-Anderson, J.; French, D.M.; Peterson, A.S.; Sonoda, J.

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes PLoS Genetics, 2011, ISSN: 1553-7390

Taylor, K.E.; Chung, S.A.; Graham, R.R.; Ortmann, W.A.; Lee, A.T.; Langefeld, C.D.; Jacob, C.O.; Kamboh, M.I.; Alarc&oacuten;-Riquelme, M.E., Tsao, B.P.; Moser, K.L.; Gaffney, P.M.; Harley, J.B.; Petri, M.; Manzi, S.; Gregersen, P.K.; Behrens, T.W.; Criswell, L.A.

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 2011, ISSN: 0002-9297

Lanktree, M.B.; Keating, B.J.; et al. (Bhangale, T.)

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells. Blood, 2011, ISSN: 0006-4971

Favre, D.; Stoddart, C.A.; Emu, B.;Hoh, R.; Martin, J.N.; Hecht, F.M.; Deeks, S.G.; McCune, J.M.

Sensitivity to Anti-Tubulin Chemotherapeutics is regulated by Mcl-1 and FBW7 Nature, 2011, ISSN: 0028-0836

Wertz, Ingrid; Kusam, Saritha; Lam, Cynthia; Okamoto, T.; Sandoval, Wendy; Anderson, D.J.; Helgason, E.; Ernst, James; Eby, M.; Liu, Jinfeng; Belmont, L.D.; Kaminker, Joshua; O'Rourke, Karen; Pujara, Kanan; Kohli, Pawan; Johnson, Adam; Chiu, M.L.; Lill, Jennie; Jackson, P.K.; Fairbrother, Wayne; Seshagiri, Somasekar; Ludlam, M.J.C.; Leong, K.G.; Dueber, E.C.; Maecker, H.; Huang, D.C.S.; Dixit, Vishva

Benzo[a]pyrene Increases the Nrf2 Content by Downregulating the Keap1 Message. Toxicological Sciences, 2010, ISSN: 1096-6080

Nguyen, P.M.; Park, M.S.; Chow, M.; Chang, J.H.; Wrischnik, L.; Chan, W.K.

Pregnancy outcomes after maternal exposure to rituximab. Blood, 2011, ISSN: 0006-4971

Chakravarty, E.F.; Murray, E.R.; Kelman, A.; Farmer, P.

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening. Drug Metabolism and Disposition, {Drug-Metab-Dispos}, June 2011, vol. 39, no. 6, p. 952-965, 22 refs, CODEN: DMDSA, eISSN: 1521-009X, ISSN: 0090-9556. Publisher: American Society for Pharmacology and Experimental Therapy, 9650 Rockville Pike, Bethesda, MD 20814, USA.

Yue, Qin; Chen, Yung Hsiang; Mulder, Teresa; Deese, Alan; Takahashi, Ryan; Rudewicz, Patrick J; Reynolds, Mark; Solon, Eric; Hop, Cornelis ECA; Wong, Harvey; Khojasteh, S Cyrus

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes p450. Drug Metabolism and Disposition, 2011, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PLoS One, 2011, ISSN: 1932-6203

Lee, G.; Origanti, S.; White, L.; Sun, J.; Stappenbeck, T.; Piwnica-Worms, H.

TRAPing a new gene for autoimmunity. Nature Genetics, 2011, ISSN: 1546-1718

Behrens, T.; Graham, R.

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells. Cancer Cell, 2011, ISSN: 1535-6108

Wilson, N.; Yang, B.; Yang, A.; Loeser, S.; Marsters, S.; Lawrence, D.; Li, Y.; Pitti, R.; Totpal, K.; Yee, S.; Ross, S.; Vernes, J.; Lu, Y.; Adams, C.; Offringa, R.; Kelley, B.; Hymowitz, S.; Daniel, D.; Meng, G.; Ashkenazi, A.

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease. Neuron, 2011, ISSN: 1097-4199

Bingol, B.; Sheng, M.

Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary LC-MS. Analytical Biochemistry, 2011, ISSN: 1096-0309

Xu, K.; Liu, L.; Saad, O.; Baudys, J.; Williams, L.; Leipold, D.; Shen, B.; Raab, H.; Junutula, J.; Kim, A.; Kaur, S.

Glucocorticoid-induced Leucine Zipper 1 Stimulates the Epithelial Sodium Channel by Regulating Serum- and Glucocorticoid-induced Kinase 1 Stability and Subcellular Localization. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, ISSN: 0021-9258

Soundararajan, R.; Wang, J.; Melters, D.; Pearce, D.

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Batten, M.; Ramamoorthi, N.; Kljavin, N.; Ma, C.; Cox, J.; Dengler, H.; Danilenko, D.; Caplazi, P.; Wong, M.; Fulcher, D.; Cook, M.; King, C.; Tangye, S.; de Sauvage, F.; Ghilardi, N.

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell, 2011, ISSN: 1878-1551

Koch, A.; Mathivet, T.; Larrivee, B.; Tong, R.; Kowalski, J.; Pibouin-Fragner, L.; Bouvree, K.; Stawicki, S.; Nicholes, K.; Rathore, N.; Scales, S.; Luis, E.; Del, T.; Freitas, C.; Breant, C.; Michaud, A.; Corvol, P.; Thomas, J.; Wu, Y.; Peale, F.; Watts, R.; Tessier-Lavigne, M.; Bagri, A.; Eichmann, A.

UNCovering the Molecular Machinery of Dependence Receptor Signaling. Molecular Cell, 2010, ISSN: 1097-4164

Bagri, A.; Ashkenazi, A.

Translational Pharmacokinetics and Pharmacodynamics of an FcRn-Variant Anti-CD4 Monoclonal Antibody From Preclinical Model to Phase I Study. Clinical Pharmacology and Therapeutics, 2010, ISSN: 1532-6535

Zheng, Y.; Scheerens, H.; Davis, J.C.; Deng, R.; Fischer, S.K.; Woods, C.; Fielder, P.J.; Stefanich, E.G.

Identification of IgG(1) variants with increased affinity to Fcγ RIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.; Meng, Y.G.

Utility of inter-system extrapolation factors (ISEFs) in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochrome P450s. Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

NFKBIA Deletion in Glioblastomas. New England Journal of Medicine, 2010, ISSN: 1533-4406

Bredel, M.; Scholtens, D.M.; Yadav, A.K.; Alvarez, A.A.; Renfrow, J.J,; Chandler, J.P.; Yu, I.L.; Carro, M.S.; Dai, F.; Tagge, M.J.; Ferrarese, R.; Bredel, C.; Phillips, H.S.; Lukac, P.J.; Robe, P.A.; Weyerbrock, A.; Vogel, H.; Dubner, S.; Mobley, B.; He, X.; Scheck, A.C.; Sikic, B.I.; Aldape, K.D.; Chakravarti, A.; Harsh, G.R.

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After Prior HER2-Directed Therapy. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Burris, H.A.; Rugo, H.S.; Vukelja, S.J.; Vogel, C.L.; Borson, R.A.; Limentani, S.; Tan, C.E.; Krop, I.E.; Michaelson, R.A.; Girish, S.; Amler, L.; Zheng, M.; Chu, Y.W.; Klencke, B.; O'Shaughnessy, J.A.

IL-27 promotes T cell-dependent colitis through multiple mechanisms. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Cox, J.H.; Kljavin, N.M.; Ramamoorthi, N.; Diehl, L.; Batten, M.; Ghilardi, N.

Identification of Isomerization and Racemization of Aspartate in the Asp-Asp Motifs of a Therapeutic Protein. Analytical Biochemistry, 2010, ISSN: 1096-0309

Zhang, J.; Yip, H.; Katta, V.

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets. Immunity, 2010, ISSN: 1074-7613

Palucka, K.; Banchereau, J.; Mellman, I.

Reply to Talloen et al.: Independent filtering is a generic approach that needs domain specific adaptation. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Bourgon, R.; Gentleman, R.; Huber, W.

Identification and functional analysis of endothelial tip cell-enriched genes. Blood, 2010, ISSN: 0006-4971

del Toro, R.; Prahst, C.; Mathivet, T.; Siegfried, G.; Kaminker, J.S.; Larrivee, B,; Breant, C.; Duarte, A.; Takakura, N.; Fukamizu, A.; Penninger, J.; Eichmann, A.

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO Journal, 2010, ISSN: 1460-2075

Dynek, J.N.; Goncharov, T.; Dueber, E.C.; Fedorova, A.V.; Izrael-Tomasevic, A.; Phu, L.; Helgason, E.; Fairbrother, W.J.; Deshayes, K.; Kirkpatrick, D.S.; Vucic, D.

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling. Molecular Cell, 2010, ISSN: 1097-2765

Bosanac, I.; Wertz, I.E.; Pan, B.; Yu, C.; Kusam, S.; Lam, C.; Phu, L.; Phung, Q.; Maurer, B.; Arnott, D.; Kirkpatrick, D.S.; Dixit, V.M.; Hymowitz, S.G.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis Nature Chemical Biology, 2010, ISSN: 1552-4469

Di Paolo, Julie; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai; Bravo, Brandon; Carano, Richard; Darrow, James; Davies, Douglas; DeForge, Laura; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven; Giannetti, Anthony; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah; Jones, Randall; Kropf, Jeffrey; Lee, Wyne; Maciejewski, Patricia; Mitchell, Scott; Rong, Hong; Staker, Bart; Whitney, Andrew; Yeh, Sherry; Young, Wendy; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin

Unleashing cell death: the Fas-FADD complex. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Hymowitz, S.G.; Dixit, V.M.

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development, 2010, ISSN: 0950-1991

Seidel, K.; Ahn, C.; Lyons, D.; Nee, A.; Ting, K.; Brownell, I.; Cao, T.; Carano, R.; Curran, T.; Schober, M.; Fuchs, E.; Joyner, A.; Martin, G.; de Sauvage, F.; Klein, O.

Regulation of Cytokine Secretion in Human CD127(+) LTi-like Innate Lymphoid Cells by Toll-like Receptor 2. Immunity, 2010, ISSN: 1074-7613

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Satoh, T.N.; DiSanto, J.P.; Spits, H.

Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood, 2010, ISSN: 0006-4971

Jo, S.H.; Schatz, J.H.; Acquaviva, J.; Singh, H.; Ren, R.

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes. Developmental Cell, 2010, ISSN: 1534-5807

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; Baron, R.

Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying. Pharmaceutical Research, 2010, ISSN: 0724-8741

Sundaramurthi, P.; Patapoff, T.W.; Suryanarayanan, R.

Clinical Experience With Hedgehog Pathway Inhibitors. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Low, J.A.; de Sauvage, F.J.

Electrostatic Docking of a Supramolecular Host-Guest Assembly to Cytochrome c Probed by Bidirectional Photoinduced Electron Transfer. Journal of the American Chemical Society, 2010, ISSN: 1520-5126

Jankowska, K.I.; Pagba, C.V.; Piatnitski Chekler, E.L.; Deshayes, K.; Piotrowiak, P.

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genetics, 2010, ISSN: 1061-4036

Otto, E.; Hurd, T.; Airik, R.; Chaki, M.; Zhou, W.; Stoetzel, C.; Patil, S.; Levy, S.; Ghosh, A.; Murga- Zamalloa, C.; van Reeuwijk, J.; Letteboer, S.; Sang, L.; Giles, R.; Liu, Q.; Coene, K.; Estrada-Cuzcano, A.; Collin, R.; McLaughlin, H.; Held, S.; Kasanuki, J.; Ramaswami, G.; Conte, J.; Lopez, I.; Washburn, J.; MacDonald, J.; Hu, J.; Yamashita, Y.; Maher, E.; Guay-Woodford, L.; Neumann, H.; O

Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Khojasteh, S.C.; Oishi, S.; Nelson, S.

Developmental Immunotoxicology Assessment of Rituximab in Cynomolgus Monkeys. Toxicological Sciences, 2010, ISSN: 1096-0929

Vaidyanathan, A.; McKeever, K.; Anand, B.; Eppler, S.; Weinbauer, G.; Beyer, J.

Vegf regulates embryonic erythroid development through Gata1 modulation. Blood, 2010, ISSN: 0006-4971

Drogat, B.; Kalucka, J.; Gutierrez, L.; Hammad, H.; Goossens, S.; Ghahremani, M.F.; Bartunkova, S.; Haigh, K.; Deswarte, K.; Nyabi, O.; Naessens, M.; Ferrara, N.; Klingmueller, U.; Lambrecht, B.; Nagy, A.; Philipsen, S.; Haigh, J.

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood, 2010, ISSN: 0006-4971

Moll, M.; Andersson, S.; Smed-Soerensen, A.; Sandberg, J.

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nature Medicine, 2010, ISSN: 1546-170X

Ferrara, N.

Optimizing Collection of Adverse Event Data in Cancer Clinical Trials Supporting Supplemental Indications. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Kaiser, L.; Melemed, A.; Preston, A.; Chaudri, R.; Hilary, A.; Niedzwiecki, D.; Fyfe, G.; Gough, J.; Bushnell, W.; Stephens, C.; Mace, M.K.; Abrams, J.; Schilsky, R.

Even Neurons Are Excited by Th17 Cells. Immunity, 2010, ISSN: 1097-4180

Egen, J.; Ouyang, W.

Cancer: miRNA Addiction - Depending On Life's Little Things. Current Biology, 2010, ISSN: 1879-0445

Dornan, D.; Settleman, J.

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Zhihua, J.Q.; Ying, Y.; Fox, M.; Peng, K.; Lewin-Koh, S.-C.; Coleman, D.; Good, J.; Lowe, J.; Rahman, A.; Yang, J.; Jiang, J.; Quarmby, V.; Song, A.

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Landgraf, K.E.; Santell, L.; Billeci, K.L.; Quan, C.; Young, J.C.; Maun, H.R.; Kirchhofer, D.; Lazarus, R.A.

Molecular Biomarker Analyses Using Circulating Tumor Cells PLoS ONE, 2010, ISSN: 1932-6203

Punnoose, E.; Atwal, S.; Spoerke, J.; Savage, H.; Pandita, A.; Yeh, R.-F.; Pirzkall, A.; Fine, B.; Amler, L.; Chen, D.; Lackner, M.

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation. Current Opinion in Cell Biology, 2010, ISSN: 1879-0410

Yang, A.; Wilson, N.; Ashkenazi, A.

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies PloS ONE, 2010, ISSN: 1932-6203

Gong, Y.; Bourhis, E.; Chiu, C.; Stawicki, S.; DeAlmeida, V.; Liu, B.; Phamluong, K.; Cao, T.; Carano, R.; Ernst, J.; Solloway, M.; Rubinfeld, B.; Hannoush, R.; Wu, Y.; Polakis, P.; Costa, M.

Evaluation of Heterophilic Antibody Blocking Agents in Reducing False Positive Interference in Immunoassays for IL-17AA, IL-17FF, and IL-17AF. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Deforge, L.; Loyet, K.; Delarosa, D.; Chinn, J.; Zamanian, F.; Chuntharapai, A.; Lee, J.; Hass, P.; Wei, N.; Townsend, M.; Wang, J.; Wong, W.L.

Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer Science Translational Medicine, 2010, ISSN: 1946-6242

Wallin, J.; Guan, J.; Prior, W.-W.; Edgar, K.; Kassees, R.; Sampath, D.; Belvin, M.; Friedman, L.

Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression. Neuron, 2010, ISSN: 0896-6273

Kuwako, K.; Kakumoto, K.; Imai, T.; Igarashi, M.; Hamakubo, T.; Sakakibara, S.; Tessier-Lavigne, M.; Okano, H.J.; Okano, H.

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

He, Y.; Wortmann, A.; Burke, L.; Reid, J.; Adams, M.; Abdul-Jabbar, I.; Quigley, J.; Leduc, R.; Kirchhofer, D.; Hooper, J.

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Fiorillo, E.; Orru, V.; Stanford, S.; Liu, Y.; Salek, M.; Rapini, N.; Schenone, A.; Saccucci, P.; Delogu, L.; Angelini, F.; Bitti, M.L.M.; Schmedt, C.; Chan, A.C.; Acuto, O.; Bottini, N.

Double TIP-ping. Science, 2010, ISSN: 1095-9203

Singh, H.; Demarco, I.

Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations. PLoS ONE, 2010, ISSN: 1932-6203

McCurley, N.; Mellman, I.

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature. PLoS ONE, 2010, ISSN: 1932-6203

Scott, A.; Powner, M.; Gandhi, P.; Clarkin, C.; Gutmann, D.; Johnson, R.; Ferrara, N.; Fruttiger, M.

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. Journal of Experimental Medicine, 2010, ISSN: 0022-1007

Broz, P.; Newton, K.;Lamkanfi, M.; Mariathasan, S.; Dixit, V.; Monack, D.

New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain. Neuron, 2010, ISSN: 0896-6273

Kaneko, N.; Marin, O.; Koike, M.; Hirota, Y.; Uchiyama, Y.; Wu, J.; Lu, Q.; Tessier-Lavigne, M.; Alvarez-Buylla, A.; Okano, H.; Rubenstein, J.; Sawamoto, K.

Manipulation of Host Cell Death Pathways during Microbial Infections. Cell Host & Microbe, 2010, ISSN: 1931-3128

Lamkanfi, M.; Dixit, V.

β-catenin balances immunity. Science, 2010, ISSN: 1095-9203

Mellman, I.; Clausen, B.

Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood, 2010, ISSN: 1528-0020

Dornan, D.; Spleiss, O.; Yeh, R.; Duchateau-Nguyen, G.; Dufour, A.; Zhi, J.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 2010, ISSN: 1476-4687

Kan, Z.; Jaiswal, B.; Stinson, J.; Janakiraman, V.; Bhatt, D.; Stern, H.; Yue, P.; Haverty, P.; Bourgon, R.; Zheng, J.; Moorhead, M.; Chaudhuri, S.; Tomsho, L.; Peters, B.; Pujara, K.; Cordes, S.; Davis, D.; Carlton, V.; Yuan, W.; Li, L.; Wang, W.; Eigenbrot, C.; Kaminker, J.; Eberhard, D.; Waring, P.; Schuster, S.; Modrusan, Z.; Zhang, Z.; Stokoe, D.; de Sauvage, F.; Faham, M.; Seshagiri, S.

Structural basis for high-affinity HER2 receptor binding by an engineered protein. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Eigenbrot, C.; Ultsch, M.; Dubnovitsky, A.; Abrahmsen, L.; Haerd, T.

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nature Genetics, 2010, ISSN: 1546-1718

Ferreira, R.; Pan-Hammarstroem, Q.; Graham, R.; Gateva, V.; Fontan, G.; Lee, A.; Ortmann, W.; Urcelay, E.; Fernandez-Arquero, M.; Nunez, C.; Jorgensen, G.; Ludviksson, B.; Koskinen, S.; Haimila, K.; Clark, H.; Klareskog, L.; Gregersen, P.; Behrens, T.; Hammarstroem, L.

Long live science! Long live the hedgehog! (Vive la science! Vive le herisson!) EMBO Reports, 2010, ISSN: 1469-221X

Reiter, J.; de Sauvage, F.

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nature Immunology, 2010, ISSN: 1529-2908

Hodson, D.; Janas, M.; Galloway, A.; Bell, S.; Andrews, S.; Li, C.; Pannell, R.; Siebel, C.; Mac Donald, H.R.; De Keersmaecker, K.; Ferrando, A.; Grutz, G.; Turner, M.

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody. Molecular Cell, 2010, ISSN: 1097-4164

Matsumoto, M.; Wickliffe, K.; Dong, K.; Yu, C.; Bosanac, I.; Bustos, D.; Phu, L.; Kirkpatrick, D.; Hymowitz, S.; Rape, M.; Kelley, R.; Dixit, V.

Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature Biotechnology, 2010, ISSN: 1087-0156

Domann, P.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusuess, C.; Perrett, D.; Quaglia, M.; Rapp, E.; Smallshaw, L.; Smith, N.; Smyth, W.F.; Taylor, C.

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. New England Journal of Medicine, 2010, ISSN: 0028-4793

Stone, J.; Merkel, P.; Spiera, R.; Seo, P.; Langford, Carol, A.; Hoffman, G.; Kallenberg, C.; St. Clair, E.W.; Turkiewicz, A.; Tchao, N.; Webber, L.; Ding, L.; Sejismundo, L.; Mieras, K.; Weitzenkamp, D.; Ikle, D.; Seyfert-Margolis, V.; Mueller, M.; Brunetta, P.; Allen, N.; Fervenza, F.; Geetha, D.; Keogh, K.; Kissin, E.; Monach, P.; Peikert, T.; Stegeman, C.; Ytterberg, S.; Specks, U.

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

Cao, S.; Yaqoob, U.; Das, A.; Shergill, U.; Jagavelu, K.; Huebert, R.; Routray, C.; Abdelmoneim, S.; Vasdev, M.; Leof, E.; Charlton, M.; Watts, R.; Mukhopadhyay, D.; Shah, V.

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature, 2010, ISSN: 0028-0836

Surolia, I.; Pirnie, S.; Chellappa, V.; Taylor, K.; Cariappa, A.; Moya, J.; Liu, H.; Bell, D.; Driscoll, D.; Diederichs, S.; Haider, K.; Netravali, I.; Le, S.; Elia, R.; Dow, E.; Lee, A.; Freudenberg, J.; De Jager, P.; Chretien, Y.; Varki, A.; MacDonald, M.; Gillis, T.; Behrens, T.; Bloch, D.; Collier, D.; Korzenik, J.; Podolsky, D.; Hafler, D.; Murali, M.; Sands, B.; Stone, J.; Gregersen, P.; Pi

The Tripartite Motif Protein MADD-2 Functions with the Receptor UNC-40 (DCC) in Netrin-Mediated Axon Attraction and Branching. Developmental Cell, 2010, ISSN: 1534-5807

Hao, J.; Adler, C.; Mebane, L.; Gertler, F.; Bargmann, C.; Tessier-Lavigne, M.

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia Cell, 2010, ISSN: 0092-8674

Jin, H.; White, S.R.; Shida, T.; Schulz, S.; Aguiar, M.; Gygi, S.P.; Bazan, J.F.; Nachury, M.V.

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nature Immunology, 2010, ISSN: 1529-2908

Takamatsu, H.; Takegahara, N.; Nakagawa, Y.; Tomura, M.; Taniguchi, M.; Friedel, R.; Rayburn, H.; Tessier-Lavigne, M.; Yoshida, Y.; Okuno, T.; Mizui, M.; Kang, S.; Nojima, S.; Tsujimura, T.; Nakatsuji, Y.; Katayama, I.; Toyofuku, T.; Kikutani, H.; Kumanogoh, A.

Leachables from Saline-Containing IV Bags Can Alter Therapeutic Protein Properties. Pharmaceutical Research, 2010, ISSN: 1573-904X

Chang, J.; Xiao, N.; Zhu, M.; Zhang, J.; Hoff, E.; Russell, S.; Katta, V.; Shire, S.

Role of Myeloid and Other Stromal Cell Types in Tumor Angiogenesis. Blood, 2009, ISSN: 0006-4971

Ferrara-Napoleone.;

FcRL5 as a Target of Antibody-Drug Conjugates for the Treatment of Multiple Myeloma. Blood, 2009, ISSN: 0006-4971

Polson, A.G.; Zheng, B.; Elkins, K.; Lau, J.; Go, M.A.; Scales, S.J.; Yu, S.F.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

FC-Gamma Receptor (FCGR) 2A and 3A Polymorphisms Do Not Influence the Outcome of Relapsed or Refractory CLL Patients Treated with Rituximab, Fludarabine, and Cyclophosphamide (R-FC) or Fludarabine, and Cyclophosphamide (FC) Alone. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Spleiss, O.; Yeh, R.F.; Duchateau-Nguyen, G.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

The PI3K Inhibitor GDC-0941 Induces Growth Arrest and Apoptosis of Acute Myeloid Leukemia Cells. Blood, 2009, ISSN: 0006-4971

Sun-Laura; Berry-Leanne, Du-Changchun, Ma-Xiaoju-Max, Shi-Lily, Medeiros-Bruno-C, Ebens-Allen-J.;

CD40 Pathway Activation Status Predicts Response to CD40 Targeted Therapy in Diffuse Large b-Cell Lymphoma. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Burington, B.; Yue, P.; Shi, X.; Advani, R.; Yu, N.; Lau, J.T.; Yu, S.F.; De Vos, S.; Ansell, S.M.; Forero-Torres, A.; Modrusan, Z.; Koeppen, H.; Yang, T.; Du, C.; Elkins, K.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.J.

Higher Doses of Rituximab May Be Required for Patients with CLL as Compared to NHL Based On Population Pharmacokinetic (PK) Modeling. Blood, 2009, ISSN: 0006-4971

Li, J.; Zhi, J.; Wenger, M.K.; Valente, N.; Visich, J.

The PI3K Inhibitor GDC-0941 Synergizes with Standard of Care Therapies to Induce Growth Inhibition and Apoptosis of Multiple Myeloma Cells. Blood, 2009, ISSN: 0006-4971

Munugalavadla, V.; Berry, L.; Du, C.; Mariathasan, S.; Slaga, D.; Sun, L.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

O-Fucose Modulates Notch-Controlled Blood Lineage Commitment. American Journal of Pathology, 2010, ISSN: 0002-9440

Yan, Q.; Yao, D.; Wei, L.; Huang, Y.; Myers, J.; Zhang, L.; Xin, W.; Shim, J.; Man, Y.; Petryniak, B.; Gerson, S.; Lowe, J.; Zhou, L.

A mouse knockout library for secreted and transmembrane proteins. Nature Biotechnology, 2010, ISSN: 1546-1696

Tang, T.; Li, L.; Tang, J.; Li, Y.; Lin, W.Y.; Martin, F.; Grant, D.; Solloway, M.; Parker, L.; Ye, W.; Forrest, W.; Ghilardi, N.; Oravecz, T.; Platt, K.; Rice, D.; Hansen, G.; Abuin, A.; Eberhart, D.; Godowski, P.; Holt, K.; Peterson, A.; Zambrowicz, B.; de Sauvage, F.

Caspase-3 Activation via Mitochondria is Required for Long-Term Depression and AMPA Receptor Internalization. Cell, 2010, ISSN: 0092-8674

Li, Z.; Jo, J.; Jia, J.M.; Lo, S.C.; Whitcomb, D.J.; Jiao, S.; Cho, K.; Sheng, M.

The chemical toolbox for monitoring protein fatty acylation and prenylation. Nature Chemical Biology, 2010, ISSN: 1552-4469

Hannoush, R,; Sun, J.

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood, 2010, ISSN: 1528-0020

Strasser, G.; Kaminker, J.; Tessier-Lavigne, M.

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. Journal of Clinical Investigation, 2010, ISSN: 1558-8238

Brightbill, H.; Jeet, S.; Lin, Z.; Yan, D.; Zhou, M.; Tan, M.; Nguyen, A.; Yeh, S.; Delarosa, D.; Leong, S.; Wong, T.; Chen, Y.; Ultsch, M.; Luis, E.; Ramani, S.; Jackman, J.; Gonzalez, L.; Dennis, M.; Chuntharapai, A.; DeForge, L.; Meng, Y.; Xu, M.; Eigenbrot, C.; Lee, W.; Refino, C.; Balazs, M.; Wu, L.

Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum interference. Journal of Immunological Methods, 2010, ISSN: 0022-1759

McCutcheon, K.; Quarmby, V.; Song, A.

Independent Adjudication of Symptomatic Heart Failure With the Use of Doxorubicin and Cyclophosphamide Followed by Trastuzumab Adjuvant Therapy: A Combined Review of Cardiac Data From the National Surgical Adjuvant Breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Russell, S.; Blackwell, K.; Lawrence, J.; Pippen, J. E. Jr.; Roe, M.; Wood, F.; Paton, V.; Holmgren, E; Mahaffey, K.

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Jones, J.; Kayagaki, N.; Broz, P.; Henry, T.; Newton, K. O'Rourke, K.; Chan, S.; Dong, J.; Qu, Y.; Roose-Girma, M.; Dixit, V.; Monack, D.

Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941 Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Salphati, L.; Wong, H.; Belvin, M.; Bradford, D.; Edgar, K.; Prior, W.; Sampath, D.; Wallin, J.

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell, 2010, ISSN: 1535-6108

Noushmehr, H.; Weisenberger, D.J.; Diefes, K.; Phillips, H.S.; Pujara, K.; Berman, B.P.; Pan, F.; Pelloski, C.E.; Sulman, E.P.; Bhat, K.P.; Verhaak, R.G.W.; Hoadley, K.A.; Hayes, D.N.; Perou, C.M.; Schmidt, H.K.; Ding, L.; Wilson, R.K.; Van Den Berg, D.; Shen, H.; Bengtsson, H.; Neuvial, P.; Cope, L.M.; Buckley, J.; Herman, J.G.; Baylin, S.B.; Laird, P.W.; Aldape, K.

The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature, 2010, ISSN: 1476-4687

Lee, W.; Jiang, Z.; Liu, J.; Haverty, P.; Guan, Y.; Stinson, J.; Yue, P.; Zhang, Y.; Pant, K.; Bhatt, D.; Ha, C.; Johnson, S.; Kennemer ,M.; Mohan, S.; Nazarenko, I.; Watanabe, C.; Sparks, A.; Shames, D.; Gentleman, R.; de Sauvage, F.; Stern, H.; Pandita, A.; Ballinger, D.; Drmanac, R.; Modrusan, Z.; Seshagiri, S.; Zhang, Z.

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site Journal of Biological Chemistry, 2010, ISSN: 1083-351X

Maun, H.R.; Wen, X.; Lingel, A.; de Sauvage, F.J.; Lazarus, R.A.; Scales, S.J.; Hymowitz, S.G.

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature, 2010, ISSN: 0028-0836

Baranzini, S.; Mudge, J.; van Velkinburgh, J.; Khankhanian, P.; Khrebtukova, I.; Miller, N.; Zhang, L.; Farmer, A.; Bell, C.; Kim, R.; May, G.; Woodward, J.; Caillier, S.; McElroy, J.; Gomez, R.; Pando, M.; Clendenen, L.; Ganusova, E.; Schilkey, F.; Ramaraj, T.; Khan, O.; Huntley, J.; Luo, S.; Kwok, P.; Wu, T.; Schroth, G.; Oksenberg, J.; Hauser, S.; Kingsmore, S.

Signalling lessons from death receptors: the importance of cleavage. Nature Cell Biology, 2010, ISSN: 1476-4679

Dixit, V.

Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathogens, 2010, ISSN: 1553-7374

Carlsson, F.; Kim, J.; Dumitru, C.; Barck, K.; Carano, R.; Sun, M.; Diehl, L.; Brown, E.

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Herbst, R.; Eckhardt, S.; Kurzrock, R.; Ebbinghaus, S.; O'Dwyer, P.; Gordon, M.; Novotny, W.; Goldwasser, M.; Tohnya, T.; Lum, B.; Ashkenazi, A. Jubb, A.; Mendelson, D.

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nature Biotechnology, 2010, ISSN: 1546-1696

Singh, M.; Lima, A.; Molina, R.; Hamilton, P.; Clermont, A.; Devasthali, V.; Thompson, J.; Cheng, J.H.; Bou-Reslan, H.; Ho, C.C.K.; Cao, T., Lee, C., Nannini, M.; Fuh, G.; Carano, R.; Koeppen, H.; Yu, R.; Forrest, W.; Plowman, G.; Johnson, Leisa

Phase I Study of Trastuzumab-DM1, a HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Krop, I.; Beeram, M.; Modi, S.; Jones, S.; Holden, S.; Yu, W.; Girish, S.; Tibbitts, J.; Yi, J.-H.; Sliwkowski, M.; Jacobson, F.; Lutzker, S.; Burris, H.

Bevacizumab and Recurrent Malignant Gliomas: A European Perspective: Reply to W. Wick et al. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Friedman, H.; Prados, M.; Wen, P.; Mikkelsen, T.; Schiff, D.; Abrey, L.; Yung, W.; Paleologos, N.; Nicholas, M.; Jensen, R.; Vredenburgh, J.; Huang, J.; Zheng, M.; Cloughesy, T.

Development of a Two-Part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Jackman, J.; Chen, Y.; Huang, A.; Moffat, B.; Scheer, J.; Leong, S.; Lee, W.; Zhang, J.; Sharma, N.; Lu, Y.; Iyer, S.; Shields, R.; Chiang, N.; Bauer, M.; Waley, D.; Roose-Girma, M.; Vandlen, R.; Yansura, D.; Wu, Y.; Wu, L.

Functions of Type II Pneumocyte-Derived Vascular Endothelial Growth Factor in Alveolar Structure, Acute Inflammation, and Vascular Permeability. American Journal of Pathology, 2010, ISSN: 0002-9440

Mura, M.; Binnie, M.; Han, B.; Li, C; Andrade, C.; Shiozaki, A.; Zhang, Y.; Ferrara, N.; Hwang, D.; Waddell, T.; Keshavjee, S.; Liu, M.

Genetic Dissection of the Function of Hindbrain Axonal Commissures. PLoS Biology, 2010, ISSN: 1544-9173

Renier, N.; Schonewille, M.; Giraudet, F.; Badura, A.; Tessier-Lavigne, M.; Avan, P.; de Zeeuw, C.; Chedotal, A.

Interplay of Dissolution, Solubility and Non-Sink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor, GDC-0449, in Dogs: An Investigation using Preclinical Studies and Physiologically- Based Pharmacokinetic Modeling Drug Metabolism and Disposition, 2010, ISSN: 0090-9556

Wong, H.; Theil, F.-P; Cui, Y; Marsters, J.; Khojasteh S.C.; Vernillet, L.; La, H.; Song, X.; Wang, H.; Morinello, E.; Deng, Y.; Hop, C.

Cancer Therapy Reform Science, 2010, ISSN: 0036-8075

Levinson, A.D.

Utility of influenza vaccination for oncology patients Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Pollyea, D.A.; Brown, J.M.Y.; Horning, S.J.

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Cliogenesis. Science Signaling, 2009, ISSN: 1937-9145

Ashique, A.M.; Choe, Y.; Karlen, M.; May, S.R.; Phamluong, K.; Solloway, M.J.; Ericson, J.; Peterson, S.A.

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma. Cancer Cell, 2010, ISSN: 1878-3686

Chen, R.; Nishimura, M.C.; Bumbaca, S.M.; Kharbanda, S.; Forrest, W.F.; Kasman, I.M.; Greve, J.M.; Soriano, R.H.; Gilmour, L.L.; Rivers, C.S.; Modrusan, Z.; Nacu, S.; Guerrero, S.; Edgar, K.A.; Wallin, J.J.; Lamszus, K.; Westphal, M.; Heim, S.; James, C.D.; VandenBerg, S.R.; Costello, J.F.; Moorefield, S.; Cowdrey, C.J.; Prados, M.; Phillips, H.S.

Rituximab Plus Fludarabine and Cyclophosphamide Prolongs Progression-Free Survival Compared With Fludarabine and Cyclophosphamide Alone in Previously Treated Chronic Lymphocytic Leukemia. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Robak, T.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Geisler, C.H.; Montillo, M.; Zyuzgin, I.; Ganly, P.S.; Dartigeas, C.; Rosta, A.; Maurer, J.; Mendila, M.; Saville, M.W.; Valente, N.; Wenger, M.K.; Moiseev, S.I.

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nature Cell Biology, 2010, ISSN: 1465-7392

Pereg, Y.; Liu, B.; O'Rourke, K.; Sagolla, M.; Dey, A.; Komuves, L.; French, D.; Dixit, V.

Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluroination. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Driscoll, J.P.; Aliagas, I.; Harris, J.J.; Halladay, J.S.; Khatib-Shahidi, S.; Deese, A.; Segraves, N.; Khojasteh-Bakht, S.C.

Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Wong, K.; Valdez, P.; Tan, C.; Yeh, S.; Hongo, J.; Ouyang, W.

Therapeutic antibody targeting of individual Notch receptors. Nature, 2010, ISSN: 1476-4687

Wu, Y.; Cain-Hom, C.; Choy, L.; Hagenbeek, T.J.; de Leon, G.P.; Chen, Y.; Finkle, D.; Venook, R.; Wu, X.; Ridgway, J.; Schahin-Reed, D.; Dow, G.J.; Shelton, A.; Stawicki, S.; Watts, R.J.; Zhang, J.; Choy, R.; Howard, P.; Kadyk, L.; Yan, M.; Zha, J.; Callahan, C.A.; Hymowitz, S.G.; Siebel, C.W.

Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2). Biochemistry, 2010, ISSN: 1520-4995

Lovitt, B.; Vanderporten, E.C.; Sheng, Z.; Zhu, H.; Drummond, J.; Liu, Y.

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth. Cell, 2010, ISSN: 1097-4172

Bais, C.; Wu, X.; Yao, J.; Yang, S.; Crawford, Y.; McCutcheon, K.; Tan, C.; Kolumam, G.; Vernes, J.M.; Eastham-Anderson, J.; Haughney, P.; Kowanetz, M.; Hagenbeek, T.; Kasman, I.; Reslan, H.B.; Ross, J.; Van Bruggen, N.; Carano, R.A.; Meng, Y.J.; Hongo, J.A.; Stephan, J.P.; Shibuya, M.; Ferrara, N.

An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G. Current Opinion in Structural Biology, 2010, ISSN: 1879-033X

Tesar, D.B.; Bjorkman, P.J.

IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathogens, 2010, ISSN: 1553-7366

Stoddart, C.A.; Keir, M.E.; McCune, J.M.

Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature, 2010, ISSN: 1476-4687

Chung, I.; Akita, R.; Vandlen, R.; Toomre, D.; Schlessinger, J.; Mellman, I.

Characteristics of rhVEGF Release from Topical Hydrogel Formulations. Pharmaceutical Research, 2010, ISSN: 0724-8741

Ji, J.Y.A.; Liu, J.; Shire, S.J.; Kamerzell, T.J.; Hong, S.; Billeci, K.; Shen, Y.; Wang, Y.J.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

O'Toole, J.F.; Liu, Y.J.; Davis, E.E.; Westlake, C.J.; Attanasio, M.; Otto, E.A.; Seelow, D.; Nurnberg, G.; Becker, C.; Nuutinen, M.; Karppa, M.; Ignatius, J.; Uusimaa, J.; Pakanen, S.; Jaakkola, E.; van den Heuvel, L.P.; Fehrenbach, H.; Wiggins, R.; Goyal, M.; Zhou, W.B.; Wolf, M.T.F.; Wise, E.; Helou, J.; Allen, S.J.; Murga-Zamalloa, C.A.; Hildebrandt, F.; et al.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 2010, ISSN: 1476-4687

Hatzivassiliou, G.; Song, K.; Yen, I.; Brandhuber, B.J.; Anderson, D.J.; Alvarado, R.; Ludlam, M.J.; Stokoe, D.; Gloor, S.L.; Vigers, G.; Morales, T.; Aliagas, I.; Liu, B.; Sideris, S.; Hoeflich, K.P.; Jaiswal, B.S.; Seshagiri, S.; Koeppen, H.; Belvin, M.; Friedman, L.S.; Malek, S.

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Vrljic, M.; Strop, P.; Ernst, J.A.; Sutton, R.B.; Chu, S.; Brunger, A.T.

Mature dendritic cells use endocytic receptors to capture and present antigens. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Platt, C.D.; Ma, J.K.; Chalouni, C.; Ebersold, M.; Bou-Reslan, H.; Carano, R.A.D.; Mellman, I.; Delamarre, L.

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Makhija, S.; Amler, L.; Glenn, D.; Ueland, F.; Gold, M.; Dizon, D.; Paton, V.; Lin, C.; Januario, T.; Ng, K.; Strauss, A.; Kelsey, S.; Sliwkowski, M.; Matulonis, U.

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood, 2010, ISSN: 0006-4971

Priceman, S.; Sung, J.; Shaposhnik, Z.; Burton, J.; Torres, C.; Moughon, D.; Johnson, M.; Lusis, A.; Cohen, D.; Iruela-Arispe, M.; Wu, L.

Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines Cell, 2010, ISSN: 0092-8674

Bingol, B.; Wang, C.F.; Arnott, D.; Cheng, D.M.; Peng, J.M.; Sheng, M.

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature, 2010, ISSN: 0028-0836

Tran., T.S.; Rubio, M.E.; Clem, R.L.; Johnson, D.; Case, L.; Tessier-Lavigne, M.; Huganir, R.L.; Ginty, D.D.; Kolodkin, A.L.

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature, 2010, ISSN: 1476-4687

Schwickart, M.; Huang, X.; Lill, J.R.; Liu, J.; Ferrando, R.; French, D.M.; Maecker, H.; O'Rourke, K.; Bazan, F.; Eastham-Anderson, J.; Yue, P.; Dornan, D.; Huang, D.C.; Dixit, V.M.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathlology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Munoz, M.; Heimesaat, M.M.; Danker, K.; Struck, D.; Lohmann, U.; Plickert, R.; Bereswill, S.; Fischer, A.; Dunay, I.R.; Wolk, K.; Loddenkemper, C.; Krell, H.W.; Libert, C.; Lund, L.R.; Frey, O.; Holscher, C.; Iwakura, Y.; Ghilardi, N.; Ouyang, W.J.; Kamradt, T.; Sabat, R.; Liesenfeld, O.

Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization. Analytical Biochemistry, 2010, ISSN: 1096-0309

Connolly, B.; Patapoff, T.W.; Wang, Y.J.; Moore, J.M.; Kamerzell, T.J.

ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2010, ISSN: 1528-0020

Niessen, K.; Zhangm, G.; Ridgway, J.B.; Chen, H.; Yan, M.

Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2+ and possible function in short-term synaptic plasticity. EMBO Journal, 2010, ISSN: 0261-4189

Rodriguez-Castaeda, F.; Maestre-Martinez, M.; Coudevylle, N.; Dimova, K.; Junge, H.; Lipstein, N.; Lee, D.; Becker, S.; Brose, N.; Jahn, O.; Carlomagno, T.; Griesinger, C.

Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 2009, ISSN: 1553-7366

Bitter, W.; Houben, E.N.G.; Bottai, D.; Brodin, P.; Brown, E..J.; Cox, J.S.; Derbyshire, K.; Fortune, S.M.; Gao, L.-Y.; Liu, J.; Van Pittius, N.C.G.; Pym, A.S.; Rubin, E.J.; Sherman, D.R.; Cole, S.T.; Brosch, R.

The inflammasomes - art. no. e1000510 PLoS Pathogens, 2009, ISSN: 1553-7366

Lamkanfi, M.; Dixit, V.

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. Journal of Cell Biology, 2010, ISSN: 0021-9525

Xu, Y.L.; Yuan, L.; Mak, J.; Pardanaud, L.; Caunt, M.; Kasman, I.; Larrivee, B.; del Toro, R.; Suchting, S.; Medvinsky, A.; Silva, J.; Yang, J.; Thomas, J.L.; Koch, A,W.; Alitalo, K.; Eichmann, A.; Bagri A.

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Xi, H.; Katschke, K.J. Jr.; Helmy, K.Y.; Wark, P.A.; Kljavin, N.; Clark, H.; Eastham-Anderson, J.; Shek, T.; Roose-Girma, M.; Ghilardi, N.; van Lookeren Campagne, M.

Stromal Cell-Derived Factor-1/CXCL12 Contributes to MMTV-Wnt1 Tumor Growth Involving Gr1+CD11b+ Cells PLoS ONE, 2010, ISSN: 1932-6203

Liu, B.Y.; Soloviev, I.; Chang, P.; Lee, J.; Huang, X.; Zhong, C.; Ferrara, N.; Polakis, P.; Sakanaka, C.

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development. Cell, 2010, ISSN: 0092-8674

Lichtenberger, B.M.; Tan, P.K.; Niederleithner, H.; Ferrara, N.; Petzelbauer, P.; Sibilia, M.

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo. Developmental Cell, 2010, ISSN: 1534-5807

Camerer, E.; Barker, A.; Duong, D.N.; Ganesan, R.; Kataoka, H.; Cornelissen, I.; Darragh, M.R.; Hussain, A.; Zheng, Y.W.; Srinivasan, Y.; Brown, C.; Xu, S.M.; Regard, J.B.; Lin, C.Y.; Craik, C.S.; Kirchhofer, D.; Coughlin, S.R.

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer Journal of Medicinal Chemistry, 2010, ISSN: 1520-4804

Sutherlin, D.P.; Sampath, D.; Berry, M.; Castanedo, G.; Chang, Z.; Chuckowree, I.; Dotson, J.; Folkes, A.; Friedman, L.; Goldsmith, R.; Heffron, T.; Lee, L.; Lesnick, J.; Lewis, C.; Mathieu, S.; Nonomiya, J.; Olivero, A.; Pang, J.; Prior, W.W.; Salphati, L.; Sideris. S.; Tian, Q.; Tsui, V.; Wan, N.C.; Wang, S.; Wiesmann, C.; Wong, S.; Zhu, B.Y.

Chronic DLL4 blockade induces vascular neoplasms. Nature, 2010, ISSN: 1476-4687

Yan, M.; Callahan, C.A.; Beyer, J.C.; Allamneni, K.P.; Zhang, G.; Ridgway, J.B.; Niessen, K.; Plowman, G.D.

Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo. PLoS ONE, 2010, ISSN: 1932-6203

Esue, O.; Rupprecht, L.; Sun, S.X.; Wirtz, D.

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Cupedo, T.; Spits, H.

Reconstitution of a Frizzled8.Wnt3a.LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6. Journal of Biological Chemistry, 2010, ISSN: 1083-351X

Bourhis, E.; Tam, C.; Franke, Y.; Bazan, J.F.; Ernst, J.; Hwang, J.; Costa, M.; Cochran, A.G.; Hannoush, R.N.

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity. A Validation Study. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Bauer, J.W.; Petri, M.; Batliwalla, F.M.; Koeuth, T.; Wilson, J.; Slattery, C.; Panoskaltsis-Mortari, A.; Gregersen, P.K.; Behrens, T.W.; Baechler EC

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Li, B.; Xi, H.K.; Diehl, L.; Lee, W.P.; Sturgeon, L.; Chinn, J.; DeForge, L.; Kelley, R.F.; Wiesmann, C.; Campagne, M.V.; Sidhu, S.S.

Characterization of oligosaccharides in recombinant tissue plasminogen activator produced in Chinese Hamster Ovary Cells: two decades of analytical technology development. Analytical Chemistry, 2009, ISSN: 0003-2700

Borisov, O.V.; Field, M.; Ling, V.T.; Harris, R.J.

Somatic mutations in p85alpha promote tumorigenesis through Class IA PI3K activation. Cancer Cell, 2009, ISSN: 1878-3686

Jaiswal, B.S.; Janakiraman, V.; Kljavin, N.M.; Chaudhuri, S.; Stern, H.M.; Wang, W.; Kan, Z.; Dbouk, H.A.; Peters, B.A.; Waring, P.; Dela Vega, T.; Kenski, D.M.; Bowman, K.K.; Lorenzo, M.; Li, H.; Wu, J.; Modrusan, Z.; Stinson, J.; Eby, M.; Yue, P.; Kaminker, J.S.; de Sauvage, F.J.; Backer, J.M.; Seshagiri, S.

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins - art. no. e1000218. Plos Biology, 2009, ISSN: 1544-9173

Tonikian, R.; Xin, X.F.; Toret, C.P.; Gfeller, D.; Landgraf, C.; Panni, S.; Paoluzi, S.; Castagnoli, L.; Currell, B.; Seshagiri, S.; Yu, H.Y.; Winsor, B.; Vidal, M.; Gerstein, M.B.; Bader, G.D.; Volkmer, R.; Cesareni, G.; Drubin, D.G.; Kim, P.M.; Sidhu, S.S.; Boone, C.

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions PLoS Genetics, 2009, ISSN: 1553-7390

Barcellos, L.F.; May, S.L.; Ramsay, P.P.; Quach, H.L.; Lane, J.A.; Nititham, J.; Noble, J.A.; Taylor, K.E.; Quach, D.L.; Chung, S.A.; Kelly, J.A.; Moser, K.L.; Behrens, T.W.; Seldin, M.F.; Thomson, G.; Harley, J.B.; Gaffney, P.M.; Criswell, L.A.

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors: insight into heterotrimeric IL-1 signaling complexes. Structure, 2009, ISSN: 1878-4186

Lingel, A.; Weiss, T.M.; Niebuhr, M.; Pan, B.; Appleton, B.A.; Wiesmann, C.; Bazan, J.F.; Fairbrother, W.J.

Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides. Pharmaceutical Research, 2009, ISSN: 0724-8741

Kosky, A.A.; Dharmavaram, V.; Ratnaswamy, G.; Manning, M.C.

Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography. Analytical Chemistry, 2009, ISSN: 1520-6882

Farnan, D.; Moreno, G.T.

Carboxylate-dependent gelation of a monoclonal antibody. Pharmaceutical Research, 2009, ISSN: 0724-8741

Esue, O.; Kanai, S.; Liu, J.; Patapoff, T.W.; Shire, S.J.

Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science, 2009, ISSN: 0036-8075

Yauch, R.L.; Dijkgraaf, G.J.P.; Alicke, B.; Januario,T.; Ahn, C.P.; Holcomb, T.; Pujara, K.; Stinson, J.; Callahan, C.A.; Tang, T.; Bazan, J.F.; Kan, Z.; Seshagiri, S.; Hann, C.L.; Gould, S.E.; Low, J.A.; Rudin, C.M.; de Sauvage, F.J.

Masking MALT1: the paracaspase's potential for cancer therapy. Journal of Experimental Medicine, 2009, ISSN: 1540-9538

Vucic, D.; Dixit, V.M.

Formulation and manufacturability of biologics. Current Opinion in Biotechnology, 2009, ISSN: 1879-0429

Shire, S.J.

Retinoic acid from the meninges regulates cortical neuron generation. Cell, 2009, ISSN: 0092-8674

Siegenthaler, J.A.; Ashique, A.M.; Zarbalis, K.; Patterson, K.P.; Hecht, J.H.; Kane, M.A.; Folias, A.E.; Choe, Y.; May, S.R.; Kume, T.; Napoli, J.L.; Peterson, A.S.; Pleasure, S.J.

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. Journal of Biological Chemistry, 2009, ISSN: 1083-351X

Varfolomeev, E.; Alicke, B.; Elliott, J.M.; Zobel, K.; West, K.; Wong, H.; Scheer, J.M.; Ashkenazi, A.; Gould, S.E.; Fairbrother, W.J.; Vucic, D.

Role of sensitivity analyses in assessing progression-free survival in late-stage oncology trials. Journal of Clinical Oncology, 2009, ISSN: 1527-7755

Bhattacharya, S.; Fyfe, G.; Gray, R.J.; Sargent, D.J.

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110 alpha and are disrupted in oncogenic p85 mutants. Proceedings of the National Academy of Sciences, 2009, ISSN: 0027-8424

Wu, H.Y.; Shekar, S.C.; Flinn, R.J.; El-Sibai, M.; Jaiswal, B.S.; Sen, K.I.; Janakiraman, V.; Seshagiri, S.; Gerfen, G.J.; Girvin, M.E.; Backer, J.M.

Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry. Analytical Chemistry, 2009, ISSN: 1520-6882

Yu, X.C.; Borisov, O.V.; Alvarez, M.; Michels, D.A.; Wang, Y.J.; Ling, V.

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Lee, E.F.; Fedorova, A.; Zobel, K.; Boyle, M.J.; Yang, H.; Perugini, M.A.; Colman, P.M.; Huang, D.C.S.; Deshayes, K.; Fairlie, W.D.

Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Socinski, M.A.; Langer, C.J.; Huang, J.E.; Kolb, M.M.; Compton, P.; Wang, L.; Akerley, W.

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nature Genetics, 2009, ISSN: 1061-4036

Gateva, V.; Sandling, J.K.; Hom, G.; Taylor, K.E.; Chung, S.A.; Sun, X.; Ortmann, W.; Kosoy, R.; Ferreira, R.C.; Nordmark, G.; Gunnarsson, I.; Svenungsson, E.; Padyukov, L.; Sturfelt, G.; Jonsen, A.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Baechler, E.C.; Brown, E.E.; Alarcon, G.S.; Edberg, J.C.; Ramsey-Goldman, R.; McGwin, G.; Reveille, J.D.; Vila, L.M.; Graham, R.R.; et al.

Bi-directional SIFT predicts a subset of activating mutations PLoS ONE, 2009, ISSN: 1932-6203

Lee, W.; Zhang, Y.; Mukhyala, K.; Lazarus, R.A.; Zhang, Z.

Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 2009, ISSN: 1878-4186

Ganesan, R.; Eigenbrot, C.; Wu, Y.; Liang, W.C.; Shia, S.; Lipari, M.T.; Kirchhofer, D.

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. Journal of Cell Biology, 2009, ISSN: 1540-8140

Lamkanfi, M.; Mueller, J.L.; Vitari, A.C.; Misaghi, S.; Fedorova. A.; Deshayes, K.; Lee, W.P.; Hoffman, H.M.; Dixit, V.M.

Antigen choice in adoptive T-cell therapy of cancer. Current Opinion in Immunology, 2009, ISSN: 0952-7915

Offringa, R.

Local guidance of emerging vessel sprouts requires soluble Flt-1 Developmental Cell, 2009, ISSN: 1534-5807

Chappell, J.C.; Taylor, S.M.; Ferrara, N.; Bautch, V.L.

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

Gill, H.S.; Tinianow, J.N.; Ogasawara, A.; Flores, J.E.; Vanderbilt, A.N.; Raab, H.; Scheer, J.M.; Vandlen, R.; Williams, S.P.; Marik, J.

Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity. Journal of Immunological Methods, 2009, ISSN: 0022-1759

Bond, E.; Adams, W.C.; Smed-Sorensen, A.; Sandgren, K.J.; Perbeck, L.; Hofmann, A.; Andersson, J.; Lore, K.

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. New England Journal of Medicine, 2009, ISSN: 0028-4793

Von Hoff, D.D.; LoRusso, P.M.; Rudin, C.M.; Reddy, J.C.; Yauch, R.L.; Tibes, R.; Weiss, G.J.; Borad, M.J.; Hann, C.L.; Brahmer, J.R.; Mackey, H.M.; Lum, B.L.; Darbonne, W.C.; Marsters, J.C.; de Sauvage, F.J.; Low J.A.

Brief Report: treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. New England Journal of Medicine, 2009, ISSN: 0028-4793

Rudin, C.M.; Hann, C.L.; Laterra, J.; Yauch, R.L.; Callahan, C.A.; Fu, L.; Holcomb, T.; Stinson, J.; Gould, S.E.; Coleman, B.; LoRusso, P.M.; Von Hoff, D.D.; de Sauvage, F.J.; Low, J.A.

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. PLoS ONE, 2009,

Blum, G.; Weimer, R.M.; Edgington, L.E.; Adams, W.; Bogyo, M.

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin's lymphoma. Blood, 2009, ISSN: 1528-0020

Dornan, D.; Bennett, F.; Chen, Y.; Dennis, M.; Eaton D.; Elkins, K.; French, D.; Go, M.A.T.; Jack, A.; Junutula, J.R.; Koeppen, H.; Lau, J.; McBride, J.; Rawstron, A.; Shi, X.; Yu, N.; Yu, S.-F.; Yue, P.; Zheng, B.; Ebens, A.; Polson, A.G.

Structural ties between cholesterol transport and morphogen signaling. Cell, 2009, ISSN: 1097-4172

Bazan, J.F.; de Sauvage, F.J.

A highly annotated whole-genome sequence of a Korean individual. Nature, 2009, ISSN: 0028-0836

Kim, J.I.; Ju, Y.S.; Park, H.; Kim, S.; Lee, S.; Yi, J.H.; Mudge, J.; Miller, N.A.; Hong, D.; Bell, C.J.; Kim, H.S.; Chung, I.S.; Lee, W.C.; Lee, J.S.; Seo, S.H.; Yun, J.Y.; Woo, H.N.; Lee, H.; Suh, D.; Lee, S.; Kim, H.J.; Yavartanoo, M.; Kwak, M.; Zheng, Y.; Lee, M.K.; Park, H.; Kim, J.Y.; ... Wu, T.D.; Kim, H.; Yang, K.-S.; ...Kingsmore, S.F.; Seo, J.-S.

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Chung, S.A.; Tian, C.; Taylor, K.E.; Lee, A.T.; Ortmann, W.A.; Hom, G.; Graham, R.R.; Nititham, J.; Kelly, J.A.; Morrisey, J.; Wu, H.; Yin, H.; Alarcon-Riquelme, M.E.; Tsao, B.P.; Harley, J.B.; Gaffney, P.M.; Moser, K.L.; Manzi, S.; Petri, M.; Gregersen, P.K.; Langefeld, C.D.; Behrens, T.W.; Seldin, M.F.; Criswell, L.A.

Investigation of sample preparation artifacts formed during the enzymatic release of N-Linked glycans prior to analysis by capillary electrophoresis. Analytical Chemistry, 2009, ISSN: 0003-2700

Liu, Y.; Salas-Solano, O.; Gennaro, L.A.

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. Journal of Cell Biology, 2009, ISSN: 0021-9525

Farr, G.A.; Hull, M.; Mellman, I.; Caplan, M.J.

FAM29A promotes microtubule amplification via recruitment of the NEDD1-γ-tubulin complex to the mitotic spindle. Journal of Cell Biology, 2008,

Zhu, H.; Coppinger, J.A.; Jang, C.Y.; Yates J.R.III; Fang, G.

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Zheng, M.; Huang, J.E.; Friedman, H.S.; Prados, M.; Wen, P.Y.; Mikkelsen, T.; Schiff, D.; Abrey, L.E.; Yung, W.K.; Paleologos, N.; Nicholas, M.K.; Jensen, R.; Vrdenburgh, J.; Cloughesy, T.

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Current Biology, 2009, ISSN: 1879-0445

Endoh-Yamagami, S.; Evangelista, M.; Wilson, D.; Wen, X.; Theunissen, J.-W.; Phamluong, K.; Davis, M.; Scales, S.J.; Solloway, M.J.; de Sauvage, F.J.; Peterson, A.S.

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Leow, C.C.; Wang, B.; Ross, J.; Chan, S.M.; Zha, J.; Carano, R.A.D.; Frantz, G.; Shen, M.M.; deSauvage, F.J.; Gao, W.-Q.

Breaking into bone biology Nature Medicine, 2009,

Choi, Y.; Walsh, M.C.; Arron, J.R.

Navigating the deubiquitinating proteome with a CompPASS.[comment]. Cell, 2009, ISSN: 1097-4172

Jackson, P.K.

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nature Immunology, 2009, ISSN: 1529-2916

Trifari, S.; Kaplan, C.D.; Tran, E.H.; Crellin, N.K.; Spits, H.

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry, 2009, ISSN: 1520-4995

Bourhis, E.; Lingel, A.; Phung, Q.; Fairbrother, W.J.; Cochran, A.G.

Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. Journal of the American Chemical Society, 2009, ISSN: 0002-7863

Burns, N.Z.; Krylova, I.N.; Hannoush, R.N.; Baran, P.S.

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Pickert, G.; Neufert, C.; Leppkes, M.; Zheng, Y.; Wittkopf, N.; Warntjen, M.; Lehr, H.A.; Hirth, S.; Weigmann, B.; Wirtz, S.; Ouyang, W.; Neurath, M.F.; Becker, C.

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Nojiri, M.; Loyet, K.M.; Klenchin, V.A.; Kabachinski, G.; Martin, T.F.J.

IL-33 raises alarm. Immunity, 2009, ISSN: 1097-4180

Lamkanfi, M.; Dixit, V.M.

TSPAN12 regulates retinal vascular development by promoting Norrin but not Wnt-induced FZD4/β-catenin signaling. Cell, 2009, ISSN: 1097-4172

Junge, H.J.; Yang, S.; Burton, J.B.; Paes, K.; Shu, X.; French, D.M.; Costa, M.; Rice, D.S.; Ye, W.

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study. Journal of Immunological Methods, 2009, ISSN: 1872-7905

Loyet, K.M.; Deng, R.; Liang, W.C.; Wu, Y.; Lowman, H.B.; DeForge, L.E.

The structure of SHH in complex with HHIP reveals a recognition role for the SHH pseudo-active site in signaling Nature Structural & Molecular Biology, 2009, ISSN: 1545-9985

Bosanac, I.; Maun, H.R.; Scales, S.J.; Wen, X.; Lingel, A.; Bazan, J.F.; de Sauvage, F.J.; Hymowitz, S.G.; Lazarus, R.A.

Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects. Journal of Clinical Pharmacology, 2009, ISSN: 0091-2700

Eley, T.; Luo, F.R.; Agrawal, S.; Sanil, A.; Manning, J.; Li, T.; Blackwood-Chirchir, A.; Bertz, R.

Follicular lymphoma in the United States: First report of the National LymphoCare Study. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Friedberg, J.W.; Taylor, M.D.; Cerhan, J.R.; Flowers, C.R.; Dillon, H.; Farber, C.M.; Rogers, E.S.; Hainsworth, J.D.; Wong, E.K.; Vose, J.M.; Zelenetz, A.D.; Link, B.K.

Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Sandler, A.B.; Schiller, J.H.; Gray, R.; Dimery, I.; Brahmer, J.; Samant, M.; Wang, L.I.; Johnson, D.H.

The PRL-1149 G/T polymorphism and rheumatoid arthritis susceptibility. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Lee, Y.C.; Raychaudhuri, S.; Cui, J.; De Vivo, I.; Ding, B.; Alfredsson, L.; Padyukov, L.; Costenbader, K.H.; Selelstad, M.; Graham, R.R.; Klareskog, L.; Gregersen, P.K.; Plenge, R.M.; Karlson, E.W.

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell, 2009, ISSN: 1934-5909

Hofmann, I.; Stover, E.H.; Cullen, D.E.; Mao, J.; Morgan, K.J.; Lee, B.H.; Kharas, M.G.; Miller, P.G.; Cornejo, M.G.; Okabe, R.; Armstrong, S.A.; Ghilardi, N.; Gould, S.; de Sauvage, F.J.; McMahon, A.P.; Ghilliland, D.G.

Targeted depletion of lymphotoxin-α-expressing TH1 and TH17 cells inhibits autoimmune disease. Nature Medicine, 2009, ISSN: 1078-8956

Chiang, E.Y.; Kolumam, G.A.; Yu, X.; Francesco, M.; Ivelja, S.; Peng, I.; Gribling, P.; Shu, J.; Lee, W.P.; Refino, C.J.; Balazs, M.; Paler-Martinez, A.; Nguyen, A.; Young, J.; Barck, K.H.; Carano, R.A.D.; Ferrando, R.; Diehl, L.; Chatterjea, D.; Grogan, J.L.

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

Aliagas-Martin, I.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Huang, O.W.; Hunsaker. T.; Kleinheinz, T.; Krueger, E.; Liang, J.; Moffat, J.; Phillips, G.; Pulk, R.; Rawson, T.E.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhu, B.Y.; Cochran, A.G.

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell, 2009, ISSN: 1097-4172

Jin, Z.; Li, Y.; Pitti, R.; Lawrence, D.; Pham, V.C.; Lill, J.R.; Ashkenazi, A.

Combined targeting of BRAF and CRAF or BRAF and P13K effector pathways is required for efficacy in NRAS mutant tumors. PloS ONE, 2009, ISSN: 1932-6203

Jaiswal, B.S.; Janakiraman, V.; Klavin, N.M.; Eastham-Anderson, J.; Cupp, J.E.; Liang, Y.; Davis, D.P.; Hoeflich, K.P.; Seshagiri, S.

Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathogens, 2009, ISSN: 1553-7374

Collins, C.A.; De Maziere, A.; van Dijk, S.; Carlsson, F.; Klumperman, J.; Brown, E.J.

Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Haines, C.J.; Giffon, T.D.; Lu, L.-S.; Lu, X.; Tessier-Lavigne, M.; Ross, D.T.; Lewis, D.B.

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell, 2009, ISSN: 1535-6108

Junttila, T.T.; Akita, R.W.; Parsons, K.; Fields, C.; Lewis Phillips, G.D.; Friedman, L.S.; Sampath, D.; Sliwkowski, M.X.

An analytical system for the characterization of highly heterogeneous mixtures of N-linked oligosaccharides. Analytical Biochemistry, 2009, ISSN: 1096-0309

Briggs, J.B.; Keck, R.G.; Ma, S.; Lau, W.; Jones, A.J.

How can we improve the translational landscape for a faster cure of type 1 diabetes? Journal of Clinical Investigation, 2009, ISSN: 0021-9738

vonHerrath, M.; Chan, A.C.

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice Journal of Clinical Investigation, 2009, ISSN: 1558-8238

Qing, J.; Du, X.; Chen, Y.M.; Chan, P.; Li, H.; Wu, P.; Marsters, S.; Stawicki, S.; Tien, J.; Totpal, K.; Ross, S.; Stinson, S.; Dornan, D.; French, D.; Wang, Q.; Stephan, J.P.; Wu, Y.; Wiesmann, C.; Ashkenazi, A.

The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development, 2009, ISSN: 0950-1991

Eshkar-Oren, I.; Viukov, S.V.; Salameh, S.; Krief, S.; Oh, C.D.; Akiyama, H.; Gerber, H.P.; Ferrara, N.; Zelzer, E.

The art of making an exit. Science, 2009, ISSN: 1095-9203

Carlsson, F.; Brown, E.J.

Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as a first-line treatment of metastatic colorectal cancer: results of the TREE study Journal of Clinical Oncology, 2008, ISSN: 0732-183X

Hochster, H.S.; Hart, L.L.; Ramanathan, R.K.; Childs, B.H.; Hainsworth, J.D.; Cohn, A.L.; Wong, L.; Fehrenbacher, L.; Abubakr, Y.; Saif, M.W.; Schwartzberg, L.; Hedrick, E.

Role of P-glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents. Drug Metabolism and Disposition, 2008, ISSN: 0090-9556

Garner, C.E.; Solon, E.; Lai, C.-M.; Lin, J.; Luo, G.; Jones, K.; Duan, J.; Decicco, C.P.; Maduskuie, T.; Mercer, S.E.; Gan, L.-S.; Qian, M.; Prakash, S.; Shen, H.-S.; Lee, F.W.

Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chemical Biology, 2009, ISSN: 1552-4469

Zhang, Y.; Appleton, B.A.; Wiesmann, C.; Lau, T.; Costa, M.; Hannoush, R.N.; Sidhu, S.S.

Death receptor signal transducers: nodes of coordination in immune signaling networks Nature Immunology, 2009, ISSN: 1529-2916

Wilson, N.S.; Dixit, V.; Ashkenazi, A.

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis Journal of Cell Biology, 2009, ISSN: 0021-9525

Mao, Y.S.; Yamaga, M.; Zhu, X.; Wei, Y.J.; Sun, H.Q.; Wang, J.; Yun, M.; Wang, Y.F.; Di Paolo, G.; Bennett, M.; Mellman, I.; Abrams, C.S.; De Camilli, P.; Lu, C.Y.; Yin, H.L.

Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population Arthritis & Rheumatism, 2009, ISSN: 0004-3591