/ Scientists


Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

937 results

Baculovirus Display for Discovery of Low-Affinity Extracellular Receptor-ligand Interactions using Protein Microarrays Analytical biochemistry, 2015, ISSN: 0003-2697

Tom, Irene; Estevez, Alberto; Bowman, Krista; Gonzalez, Lino C

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Regulation of the oncoprotein Smoothened by small molecules Nature chemical biology, 2015, ISSN: 1552-4450

Sharpe, Hayley J; Wang, Weiru; Hannoush, Rami N; de Sauvage, Frederic J

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GPU-Accelerated Compartmental Modeling Analysis of DCE-MRI Data from Glioblastoma Patients Treated with Bevacizumab PloS one, 2015, ISSN: 1932-6203

Hsu, Yu-Han H; Huang, Ziyin; Ferl, Gregory Z; Ng, Chee M

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy Science translational medicine, 2015, ISSN: 1946-6234

Leverson, Joel D; Phillips, Darren C; Mitten, Michael J; Boghaert, Erwin R; Diaz, Dolores; Tahir, Stephen K; Belmont, Lisa D; Nimmer, Paul; Xiao, Yu; Ma, Xiaoju Max; Lowes, Kym N; Kovar, Peter; Chen, Jun; Jin, Sha; Smith, Morey; Xue, John; Zhang, Haichao; Oleksijew, Anatol; Magoc, Terrance J; Vaidya, Kedar S; Albert, Daniel H; Tarrant, Jacqueline M; La, Nghi; Wang, Le; Tao, Zhi-Fu; Wendt, Michael D; Sampath, Deepak; Rosenberg, Saul H; Tse, Chris; S Huang, David C; Fairbrother, Wayne J; Elmore, Steven W; Souers, Andrew J

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MAP4K4 regulates integrin-FERM binding to control endothelial cell motility Nature, 2015, ISSN: 0028-0836

Vitorino, Philip; Yeung, Stacey; Crow, Ailey; Bakke, Jesse; Smyczek, Tanya; West, Kristina; McNamara, Erin; Eastham-Anderson, Jeffrey; Gould, Stephen; Harris, Seth F; Ndubaku, Chudi; Ye, Weilan

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Antibody Positron Emission Tomography Imaging in Anticancer Drug Development Journal of clinical oncology, 2015, ISSN: 0732-183X

Lamberts, Laetitia E; Williams, Simon P; Terwisscha van Scheltinga, Anton G T; Lub-de Hooge, Marjolijn N; Schröder, Carolien P; Gietema, Jourik A; Brouwers, Adrienne H; de Vries, Elisabeth G E

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Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway Pharmaceutical research, 2015, ISSN: 0724-8741

Saggu, Miguel; Liu, Jun; Patel, Ankit

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Obinutuzumab (G) plus fludarabine/cyclophosphamide (G-FC) or bendamustine (G-B) in the initial therapy of CLL patients: the phase 1b GALTON trial Blood, 2015, ISSN: 0006-4971

Brown, Jennifer R; O'Brien, Susan; Kingsley, C Daniel; Eradat, Herbert; Pagel, John M; Lymp, James; Hirata, Jamie; Kipps, Thomas J

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Development of orthogonally protected hypusine for solid-phase Peptide synthesis Journal of organic chemistry, 2015, ISSN: 0022-3263

Song, Aimin; Tom, Jeffrey; Yu, Zhiyong; Pham, Victoria; Tan, Dajin; Zhang, Dengxiong; Fang, Guoyong; Yu, Tao; Deshayes, Kurt

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Genomic analysis of smoothened inhibitor resistance in Basal cell carcinoma Cancer cell, 2015, ISSN: 1535-6108

Sharpe, Hayley J; Pau, Gregoire; Dijkgraaf, Gerrit J; Basset-Seguin, Nicole; Modrusan, Zora; Januario, Thomas; Tsui, Vickie; Durham, Alison B; Dlugosz, Andrzej A; Haverty, Peter M; Bourgon, Richard; Tang, Jean Y; Sarin, Kavita Y; Dirix, Luc; Fisher, David C; Rudin, Charles M; Sofen, Howard; Migden, Michael R; Yauch, Robert L; de Sauvage, Frederic J

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Structural Analysis of Bacterial ABC Transporter Inhibition by an Antibody Fragment Structure, 2015, ISSN: 0969-2126

Ahuja, Shivani; Rougé, Lionel; Swem, Danielle L; Sudhamsu, Jawahar; Wu, Ping; Russell, Stephen J; Alexander, Mary Kate; Tam, Christine; Nishiyama, Mireille; Starovasnik, Melissa A; Koth, Christopher M

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Human Biosample Authentication Using the High-Throughput, Cost-Effective SNPtraceTM System PloS one, 2015, ISSN: 1932-6203

Liang-Chu, May M Y; Yu, Mamie; Haverty, Peter M; Koeman, Julie; Ziegle, Janet; Lee, Marie; Bourgon, Richard; Neve, Richard M

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Challenges and considerations for development of therapeutic proteins in pediatric patients Journal of clinical pharmacology, 2015, ISSN: 0091-2700

Zhang, Yi; Wei, Xiaohui; Bajaj, Gaurav; Barrett, Jeffrey S; Meibohm, Bernd; Joshi, Amita; Gupta, Manish

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Feasibility and Cardiac Safety of Trastuzumab Emtansine After Anthracycline-Based Chemotherapy As (neo)Adjuvant Therapy for Human Epidermal Growth Factor Receptor 2-Positive Early-Stage Breast Cancer Journal of clinical oncology, 2015, ISSN: 0732-183X

Krop, Ian E; Suter, Thomas M; Dang, Chau T; Dirix, Luc; Romieu, Gilles; Zamagni, Claudio; Citron, Marc L; Campone, Mario; Xu, Na; Smitt, Melanie; Gianni, Luca

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Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer New England Journal of Medicine, 2015, ISSN:

Swain, Sandra M.; Baselga, José; Kim, Sung-Bae; Ro, Jungsil; Semiglazov, Vladimir; Campone, Mario; Ciruelos, Eva; Ferrero, Jean-Marc; Schneeweiss, Andreas; Heeson, Sarah; Clark, Emma; Ross, Graham; Benyunes, Mark C.; Cortés, Javier

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Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection Immunity, 2015, ISSN: 1074-7613

Muñoz, Melba; Eidenschenk, Celine; Ota, Naruhisa; Wong, Kit; Lohmann, Uwe; Kühl, Anja A; Wang, Xiaoting; Manzanillo, Paolo; Li, Yun; Rutz, Sascha; Zheng, Yan; Diehl, Lauri; Kayagaki, Nobuhiko; van Lookeren-Campagne, Menno; Liesenfeld, Oliver; Heimesaat, Markus; Ouyang, Wenjun

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Contribution of Metabolites to P450 Inhibition-Based Drug-Drug Interactions: Scholarship from the IQ DMLG Metabolite Group Drug metabolism and disposition, 2015, ISSN: 0090-9556

Yu, Hongbin; Balani, Suresh K; Chen, Weichao; Cui, Donghui; He, Ling; Humphreys, William Griffith; Mao, Jialin; Lai, W George; Lee, Anthony J; Lim, Heng-Keang; MacLauchlin, Christopher; Prakash, Chandra; Surapaneni, Sekhar; Tse, Susanna; Upthagrove, Alana; Walsky, Robert L; Wen, Bo; Zeng, Zhaopie

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung Science Translational Medicine, 2015, ISSN: 1946-6234

R. N. Fuji; M. Flagella; M. Baca; M. A. S. Baptista; J. Brodbeck; B. K. Chan; B. K. Fiske; L. Honigberg; A. M. Jubb; P. Katavolos; D. W. Lee; S.-C. Lewin-Koh; T. Lin; X. Liu; S. Liu; J. P. Lyssikatos; J. O’Mahony; M. Reichelt; M. Roose-Girma; Z. Sheng; T. Sherer; A. Smith; M. Solon; Z. K. Sweeney; J. Tarrant; A. Urkowitz; S. Warming; M. Yaylaoglu; S. Zhang; H. Zhu; A. A. Estrada; R. J. Watts,

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Targeting the extrinsic apoptotic pathway in cancer: Lessons learned and future directions Journal of Clinical Investigation, 2015, ISSN:

Ashkenazi, Avi

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Orchestrating high-throughput genomic analysis with Bioconductor Nature methods, 2015, ISSN: 1548-7091

Huber, Wolfgang; Carey, Vincent J; Gentleman, Robert; Anders, Simon; Carlson, Marc; Carvalho, Benilton S; Bravo, Hector Corrada; Davis, Sean; Gatto, Laurent; Girke, Thomas; Gottardo, Raphael; Hahne, Florian; Hansen, Kasper D; Irizarry, Rafael A; Lawrence, Michael; Love, Michael I; MacDonald, James; Obenchain, Valerie; Oleś, Andrzej K; Pagès, Hervé; Reyes, Alejandro; Shannon, Paul; Smyth, Gordon K; Tenenbaum, Dan; Waldron, Levi; Morgan, Martin

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β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10 Proceedings of the National Academy of Sciences, 2015, ISSN: 0027-8424

Fu, Chunmei; Liang, Xinjun; Cui, Weiguo; Ober-Blöbaum, Julia L; Vazzana, Joseph; Shrikant, Protul A; Lee, Kelvin P; Clausen, Björn E; Mellman, Ira; Jiang, Aimin

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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria Nature cell biology, 2015, ISSN: 1465-7392

Cunningham, Christian N; Baughman, Joshua M; Phu, Lilian; Tea, Joy S; Yu, Christine; Coons, Mary; Kirkpatrick, Donald S; Bingol, Baris; Corn, Jacob E

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Systematic Mapping of WNT-Frizzled Interactions Reveals Functional Selectivity by Distinct WNT-Frizzled Pairs Journal of biological chemistry, 2015, ISSN: 0021-9258

Dijksterhuis, Jacomijn Petronella; Baljinnyam, Bolormaa; Stanger, Karen; Sercan, Hakki Ogun; Ji, Yun; Andres, Osler; Rubin, Jeffrey S; Hannoush, Rami N; Schulte, Gunnar

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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2 Journal of Medicinal Chemistry, 2015, ISSN:

Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B.

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Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors Journal of Medicinal Chemistry, 2014, ISSN:

Cervi, Giovanni; Magnaghi, Paola; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Borghi, Daniela; Caruso, Michele; Cirla, Alessandra; Cozzi, Liviana; Felder, Eduard; Galvani, Arturo; Gasparri, Fabio; Lomolino, Antonio; Magnuson, Steven; Malgesini, Beatrice; Motto, Ilaria; Pasi, Maurizio; Rizzi, Simona; Salom, Barbara; Sorrentino, Graziella; Troiani, Sonia; Valsasina, Barbara; O'Brien, Thomas; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto

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Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design Drug metabolism and disposition, 2015, ISSN: 0090-9556

Lee, Caroline A; O'Connor, Meeghan A; Ritchie, Tasha K; Galetin, Aleksandra; Cook, Jack A; Ragueneau-Majlessi, Isabelle; Ellens, Harma; Feng, Bo; Taub, Mitchell E; Paine, Mary F; Polli, Joseph W; Ware, Joseph A; Zamek-Gliszczynski, Maciej J

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Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior Proceedings of the National Academy of Sciences, 2015, ISSN: 0027-8424

Yamazaki, Maya; Le Pichon, Claire E; Jackson, Alexander C; Cerpas, Manuel; Sakimura, Kenji; Scearce-Levie, Kimberly; Nicoll, Roger A

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Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey and Rat as Determined by Quantitative Proteomics Drug metabolism and disposition, 2014, ISSN: 0090-9556

Wang, Li; Prasad, Bhagwat; Salphati, Laurent; Chu, Xiaoyan; Gupta, Anshul; Hop, Cornelis E C A; Evers, Raymond; Unadkat, Jash D

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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Sharma, Vikas K; Patapoff, Thomas W; Kabakoff, Bruce; Pai, Satyan; Hilario, Eric; Zhang, Boyan; Li, Charlene; Borisov, Oleg; Kelley, Robert F; Chorny, Ilya; Zhou, Joe Z; Dill, Ken A; Swartz, Trevor E

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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase Toxicological sciences, 2014, ISSN: 1096-0929

Zabka, T S; Singh, J T; Dhawan, P; Liederer, B M; Oeh, J; Kauss, M A; Xiao, Y; Zak, M; Lin, T; McCray, B; La, N; Beyer, J; Farman, C; Uppal, H; Dragovich, P S; O'Brien, T; Sampath, D; Misner, D L

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A comprehensive transcriptional portrait of human cancer cell lines Nature biotechnology, 2014, ISSN: 1087-0156

Klijn, Christiaan; Durinck, Steffen; Stawiski, Eric W; Haverty, Peter M; Jiang, Zhaoshi; Liu, Hanbin; Degenhardt, Jeremiah; Mayba, Oleg; Gnad, Florian; Liu, Jinfeng; Pau, Gregoire; Reeder, Jens; Cao, Yi; Mukhyala, Kiran; Selvaraj, Suresh K; Yu, Mamie; Zynda, Gregory J; Brauer, Matthew J; Wu, Thomas D; Gentleman, Robert C; Manning, Gerard; Yauch, Robert L; Bourgon, Richard; Stokoe, David; Modrusan, Zora; Neve, Richard M; de Sauvage, Frederic J; Settleman, Jeffrey; Seshagiri, Somasekar; Zhang, Zemin

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Quantitative Transporter Proteomics by LC-MS/MS: Addressing Methodological Issues of Plasma Membrane Isolation and Expression-activity Relationship Drug metabolism and disposition, 2014, ISSN: 0090-9556

Kumar, Vineet; Prasad, Bhagwat; Patilea, Gabriela; Gupta, Anshul; Salphati, Laurent; Evers, Raymond; Hop, Cornelis E C A; Unadkat, Jashvant D

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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells Nature, 2014, ISSN: 0028-0836

Rutz, Sascha; Kayagaki, Nobuhiko; Phung, Qui T; Eidenschenk, Celine; Noubade, Rajkumar; Wang, Xiaoting; Lesch, Justin; Lu, Rongze; Newton, Kim; Huang, Oscar W; Cochran, Andrea G; Vasser, Mark; Fauber, Benjamin P; DeVoss, Jason; Webster, Joshua; Diehl, Lauri; Modrusan, Zora; Kirkpatrick, Donald S; Lill, Jennie R; Ouyang, Wenjun; Dixit, Vishva M

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Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys Pharmaceutical research, 2014, ISSN: 0724-8741

Lu, Dan; Jin, Jin Yan; Girish, Sandhya; Agarwal, Priya; Li, Dongwei; Prabhu, Saileta; Dere, Randall C; Saad, Ola M; Nazzal, Denise; Koppada, Neelima; Ramanujan, Saroja; Ng, Chee M

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Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates Pharmaceutical research, 2014, ISSN: 0724-8741

Sukumaran, Siddharth; Gadkar, Kapil; Zhang, Crystal; Bhakta, Sunil; Liu, Luna; Xu, Keyang; Raab, Helga; Yu, Shang-Fan; Mai, Elaine; Fourie-O'Donohue, Aimee; Kozak, Katherine R; Ramanujan, Saroja; Junutula, Jagath R; Lin, Kedan

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Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates Pharmaceutical research, 2014, ISSN: 0724-8741

Kamath, Amrita V; Iyer, Suhasini

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Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams. Journal of Organic Chemistry, 2014, ISSN:

Fauber, B. P.; Clagg, K.; Gibbons, P.; René, O.

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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer Nature, 2014, ISSN: 0028-0836

Powles, Thomas; Eder, Joseph Paul; Fine, Gregg D; Braiteh, Fadi S; Loriot, Yohann; Cruz, Cristina; Bellmunt, Joaquim; Burris, Howard A; Petrylak, Daniel P; Teng, Siew-Leng; Shen, Xiaodong; Boyd, Zachary; Hegde, Priti S; Chen, Daniel S; Vogelzang, Nicholas J

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature, 2014, ISSN: 0028-0836

Herbst, Roy S; Soria, Jean-Charles; Kowanetz, Marcin; Fine, Gregg D; Hamid, Omid; Gordon, Michael S; Sosman, Jeffery A; McDermott, David F; Powderly, John D; Gettinger, Scott N; Kohrt, Holbrook E K; Horn, Leora; Lawrence, Donald P; Rost, Sandra; Leabman, Maya; Xiao, Yuanyuan; Mokatrin, Ahmad; Koeppen, Hartmut; Hegde, Priti S; Mellman, Ira; Chen, Daniel S; Hodi, F Stephen

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Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing Nature, 2014, ISSN: 0028-0836

Yadav, Mahesh; Jhunjhunwala, Suchit; Phung, Qui T; Lupardus, Patrick; Tanguay, Joshua; Bumbaca, Stephanie; Franci, Christian; Cheung, Tommy K; Fritsche, Jens; Weinschenk, Toni; Modrusan, Zora; Mellman, Ira; Lill, Jennie R; Delamarre, Lélia

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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function Cancer cell, 2014, ISSN: 1535-6108

Johnston, Robert J; Comps-Agrar, Laetitia; Hackney, Jason; Yu, Xin; Huseni, Mahrukh; Yang, Yagai; Park, Summer; Javinal, Vincent; Chiu, Henry; Irving, Bryan; Eaton, Dan L; Grogan, Jane L

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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death Nature medicine, 2014, ISSN: 1078-8956

Wetzel-Smith, Monica K; Hunkapiller, Julie; Bhangale, Tushar R; Srinivasan, Karpagam; Maloney, Janice A; Atwal, Jasvinder K; Sa, Susan M; B Yaylaoglu, Murat; Foreman, Oded; Ortmann, Ward; Rathore, Nisha; Hansen, David V; Tessier-Lavigne, Marc; Mayeux, Richard; Pericak-Vance, Margaret; Haines, Jonathan; Farrer, Lindsay A; Schellenberg, Gerard D; Goate, Alison; Behrens, Timothy W; Cruchaga, Carlos; Watts, Ryan J; Graham, Robert R

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Inhibitors of p21-Activated Kinases (PAKs) Journal of Medicinal Chemistry, 2015, ISSN:

Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Weiru Wang

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8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors Journal of Medicinal Chemistry, 2014, ISSN:

Thomas, Allen A.; Hunt, Kevin W.; Newhouse, Brad; Watts, Ryan J.; Liu, Xingrong; Vigers, Guy; Smith, Darin; Rhodes, Susan P.; Brown, Karin D.; Otten, Jennifer N.; Burkard, Michael; Cox, April A.; Geck Do, Mary K.; Dutcher, Darrin; Rana, Sumeet; Delisle, Robert K.; Regal, Kelly; Wright, Albion D.; Groneberg, Robert; Liao, Jiangpeng; Scearce-Levie, Kimberly; Siu, Michael; Purkey, Hans E.; Lyssikatos, Joseph P.

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The Blood-Brain Barrier's Gut Check Science translational medicine, 2014, ISSN: 1946-6234

Bien-Ly, Nga; Watts, Ryan J

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Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes Nature genetics, 2014, ISSN: 1061-4036

Durinck, Steffen; Stawiski, Eric W; Pavía-Jiménez, Andrea; Modrusan, Zora; Kapur, Payal; Jaiswal, Bijay S; Zhang, Na; Toffessi-Tcheuyap, Vanina; Nguyen, Thong T; Pahuja, Kanika Bajaj; Chen, Ying-Jiun; Saleem, Sadia; Chaudhuri, Subhra; Heldens, Sherry; Jackson, Marlena; Peña-Llopis, Samuel; Guillory, Joseph; Toy, Karen; Ha, Connie; Harris, Corissa J; Holloman, Eboni; Hill, Haley M; Stinson, Jeremy; Rivers, Celina Sanchez; Janakiraman, Vasantharajan; Wang, Weiru; Kinch, Lisa N; Grishin, Nick V; Haverty, Peter M; Chow, Bernard; Gehring, Julian S; Reeder, Jens; Pau, Gregoire; Wu, Thomas D; Margulis, Vitaly; Lotan, Yair; Sagalowsky, Arthur; Pedrosa, Ivan; de Sauvage, Frederic J; Brugarolas, James; Seshagiri, Somasekar

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Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18 Science, 2014, ISSN: 0036-8075

Zhang, Benyue; Chassaing, Benoit; Shi, Zhenda; Uchiyama, Robin; Zhang, Zhan; Denning, Timothy L; Crawford, Sue E; Pruijssers, Andrea J; Iskarpatyoti, Jason A; Estes, Mary K; Dermody, Terence S; Ouyang, Wenjun; Williams, Ifor R; Vijay-Kumar, Matam; Gewirtz, Andrew T

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Dusp5 negatively regulates IL-33-mediated eosinophil survival and function EMBO journal, 2014, ISSN: 0261-4189

Holmes, Derek A; Yeh, Jung-Hua; Yan, Donghong; Xu, Min; Chan, Andrew C

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TNFR1-activated NF-κB signal transduction: Regulation by the ubiquitin/proteasome system Current Opinion in Chemical Biology, 2014, ISSN: 1367-5931

Wertz, Ingrid E

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Internal motions prime cIAP1 for rapid activation Nature structural & molecular biology, 2014, ISSN: 1545-9985

Phillips, Aaron H; Schoeffler, Allyn J; Matsui, Tsutomu; Weiss, Thomas M; Blankenship, John W; Zobel, Kerry; Giannetti, Anthony M; Dueber, Erin C; Fairbrother, Wayne J

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HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme Developmental Cell, 2014, ISSN: 1534-5807

Osterwalder, Marco; Speziale, Dario; Shoukry, Malak; Mohan, Rajiv; Ivanek, Robert; Kohler, Manuel; Beisel, Christian; Wen, Xiaohui; Scales, Suzie J.; Christoffels, Vincent M.; Visel, Axel; Lopez-Rios, Javier; Zeller, Rolf; Lopez-Rios, J

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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Hanan, Emily J; Eigenbrot, Charles; Bryan, Marian C; Burdick, Daniel J; Chan, Bryan K; Chen, Yuan; Dotson, Jennafer; Heald, Robert A; Jackson, Philip S; La, Hank; Lainchbury, Michael D; Malek, Shiva; Purkey, Hans E; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M; Sideris, Steve; Tam, Christine; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yin, Jianping; Yu, Christine; Zilberleyb, Inna; Heffron, Timothy P

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Ubiquitination in disease pathogenesis and treatment Nature medicine, 2014, ISSN: 1078-8956

Popovic, Doris; Vucic, Domagoj; Dikic, Ivan

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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates Science translational medicine, 2014, ISSN: 1946-6234

Yu, Y Joy; Atwal, Jasvinder K; Zhang, Yin; Tong, Raymond K; Wildsmith, Kristin R; Tan, Christine; Bien-Ly, Nga; Hersom, Maria; Maloney, Janice A; Meilandt, William J; Bumbaca, Daniela; Gadkar, Kapil; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Ernst, James A; Scearce-Levie, Kimberly; Couch, Jessica A; Dennis, Mark S; Watts, Ryan J

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Inhibiting the Deubiquitinating Enzymes (DUBs) Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Ndubaku, Chudi; Tsui, Vickie

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A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production Nature immunology, 2014, ISSN: 1529-2908

Simpson, Laura J; Patel, Sana; Bhakta, Nirav R; Choy, David F; Brightbill, Hans D; Ren, Xin; Wang, Yanli; Pua, Heather H; Baumjohann, Dirk; Montoya, Misty M; Panduro, Marisella; Remedios, Kelly A; Huang, Xiaozhu; Fahy, John V; Arron, Joseph R; Woodruff, Prescott G; Ansel, K Mark

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Preclinical efficacy of MEK inhibition in Nras mutant acute myeloid leukemia Blood, 2014, ISSN: 0006-4971

Burgess, Michael R; Hwang, Eugene; Firestone, Ari J; Huang, Tannie; Xu, Jin; Zuber, Johannes; Bohin, Natacha; Wen, Tiffany; Kogan, Scott C; Haigis, Kevin M; Sampath, Deepak; Lowe, Scott; Shannon, Kevin; Li, Qing

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Depletion of the central metabolite NAD leads to oncosis mediated cell death Journal of biological chemistry, 2014, ISSN: 0021-9258

Del Nagro, Christopher; Xiao, Yang; Rangell, Linda; Reichelt, Mike; O'Brien, Thomas

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Hepatic immune regulation by stromal cells Current Opinion in Immunology, 2015, ISSN: 0952-7915

Schildberg, Frank A; Sharpe, Arlene H; Turley, Shannon J

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The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture Nature immunology, 2014, ISSN: 1529-2908

Astarita, Jillian L; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C; Peck, James R; Nieves-Bonilla, Janice M; Song, Kai; Kondo, Yuji; Woodruff, Matthew C; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M; Carroll, Michael C; Mooney, David J; Xia, Lijun; Turley, Shannon J

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Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Patel, Snahel; Cohen, Frederick; Dean, Brian J; De La Torre, Kelly; Deshmukh, Gauri; Estrada, Anthony A; Ghosh, Arundhati Sengupta; Gibbons, Paul; Gustafson, Amy; Huestis, Malcolm P; Le Pichon, Claire E; Lin, Han; Liu, Wendy; Liu, Xingrong; Liu, Yichin; Ly, Cuong Q; Lyssikatos, Joseph P; Ma, Changyou; Scearce-Levie, Kimberly; Shin, Young G; Solanoy, Hilda; Stark, Kimberly L; Wang, Jian; Wang, Bei; Zhao, Xianrui; Lewcock, Joseph W; Siu, Michael

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Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite - A Case Study of Amiodarone Drug metabolism and disposition, 2014, ISSN: 0090-9556

Chen, Yuan; Mao, Jialin; Hop, Cornelis E C A

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Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors PloS one, 2014, ISSN: 1932-6203

Wang, Weiru; Elkins, Kristi; Oh, Angela; Ho, Yen-Ching; Wu, Jiansheng; Li, Hong; Xiao, Yang; Kwong, Mandy; Coons, Mary; Brillantes, Bobby; Cheng, Eric; Crocker, Lisa; Dragovich, Peter S; Sampath, Deepak; Zheng, Xiaozhang; Bair, Kenneth W; O'Brien, Thomas; Belmont, Lisa D

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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

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A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap PLoS Genetics, 2011, ISSN: 1553-7390

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A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis. Science Translational Medicine, 21 Sep 2011, vol. 3, no. 101, p. 101ra92, ISSN: 1946-6234, eISSN: 1946-6242.

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miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer Science signaling, 16 Aug 2011, vol. 4, no. 186, p. pt5, ISSN: 1937-9145.

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Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

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Genetic Analyses of Interferon Pathway-Related Genes Reveal Multiple New Loci Associated With Systemic Lupus Erythematosus. Arthritis & Rheumatism, 2011, V63, N7, JUL, pp 2049-2057. ISSN: 0004-3591.

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Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling PLoS ONE, {PLoS-ONE}, 2011, vol. 6, no. 7, article number: e22595, 35 refs, eISSN: 1932-6203. Publisher: Public Library of Science, 185 Berry Street, Suite 1300, San Francisco, CA 94107, USA.

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Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N21, MAY 27, pp 18969-18981. ISSN: 0021-9258.

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AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3 beta (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N19, MAY 13, pp 16879-16890. ISSN: 0021-9258.

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Rituximab's New Therapeutic Target: The Podocyte Actin Cytoskeleton. Science translational medicine, {Sci-Transl-Med}, 1 Jun 2011, vol. 3, no. 85, p. 85ps21, ISSN: 1946-6242.

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Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation. Pharmaceutical research, {Pharm-Res}, 8 Jun 2011 (epub: 8 6 2011), ISSN: 1573-904X.

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TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma PLoS ONE, 2011, ISSN: 1932-6203

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High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin is Entropy-Driven in Spite of Structural Plasticity. PloS One, 2011, ISSN: 1932-6203

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Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. BLOOD, 2011, V117, N21, MAY 26, pp 5652-5662. ISSN: 0006-4971.

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Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target. Science Translational Medicine, 2011, ISSN: 1946-6234

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COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature, 2011, ISSN: 0028-0836

Vitari, A.C.; Leong, K.G.; Newton, K.; Yee, C.; O'Rourke, K.; Liu, J.; Phu, L.; Vij, R.; Ferrando, R.; Couto, S.S.; Mohan, S.; Pandita, A.; Hongo, J.A.; Arnott, D.; Wertz, I.E.; Gao, W.Q.; French, D.M.; Dixit, V.M.

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Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Cell, 2011, ISSN: 1097-4172

Sang, L.; Miller, J.J.; Corbit, K.C.; Giles, R.H.; Brauer, M.J.; Otto, E.A.; Baye, L.M.; Wen, X.; Scales, S.J.; Kwong, M.; Huntzicker, E.G.; Sfakianos, M.K.; Sandoval, W.; Bazan, J.F.; Kulkarni, P.; Garcia-Gonzalo, F.R.; Seol, A.D.; O'Toole, J.F.; Held, S.; Reutter, H.M.; Lane, W.S.; Rafiq, M.A.; Noor, A.; Ansar, M.; Devi, A.R.; Sheffield, V.C.; Slusarski, D.C.; Vincent, J.B.; Doherty, D.A.; Hilde

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Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Journal of Clinical Investigation, 2011, ISSN: 0021-9738

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A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. Journal of Cell Biology, 2011, ISSN: 0021-9525

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An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia. Blood, 2011, ISSN: 0006-4971

Danese, M.D.; Griffiths, R.I.; Gleeson, M.; Satram-Hoang, S.; Knopf, K.; Joseph, M.; Reyes, C.

Slit2 Activity in the Migration of Guidepost Neurons Shapes Thalamic Projections during Development and Evolution. Neuron, 2011, ISSN: 0896-6273

Bielle, F.; Marcos-Mondejar, P.; Keita, M.; Mailhes, C.; Verney, C.; Ba-Charvet, K.M.; Tessier-Lavigne, M.; Lopez-Bendito, G.; Garel, S.

Do cilia put brakes on the cell cycle? Nature Cell Biology, 2011, ISSN: 1476-4679

Jackson, P.K.

Randomized Phase II Study of Bevacizumab in Combination With Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer: Results From the SALUTE Trial. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Spigel, D.R.; Townley, P.M.; Waterhouse, D.M.; Fang, L.; Adiguzel, I.; Huang, J.E.; Karlin, D.A.; Faoro, L.; Scappaticci, F.A.; Socinski, M.A.

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Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine. Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Cohen, F.; Bergeron, P.; Blackwood, E.; Bowman, K.K.; Chen, H.; DiPasquale, A.G.; Epler, J.A.; Koehler, M.F.T.; Lau, K.; Lewis, C.; Liu, L.; Ly, C.Q.; Malek, S.; Nonomiya, J.; Ortwine, D.F.; Pei, Z.; Robarge, K.D.; Sideris, S.; Trinh, L.; Truong, T.; Wu, J.; Zhao, X.; Lyssikatos, J.P.

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences, 2011, ISSN: 1091-6490

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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Sleebs, B.E.; Czabotar, P.E.; Fairbrother, W.J.; Fairlie, W.D.; Flygare, J.A.; Huang, D.C.S.; Kersten, W.J.A.; Koehler, M.F.T.; Lessene, G.; Lowes, K.; Parisot, J.P.; Smith, B.J.; Smith, M.L.; Souers, A.J.; Street, I.P.; Yang, H.; Baell, J.B.

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Stanford, S.M.; Krishnamurthy, D.; Falk, M.D.; Messina, R.; Debnath, B.; Li, S.; Liu, T.; Kazemi, R.; Dahl, R.; He, Y.; Yu, X.; Chan, A.C.; Zhang, Z.Y.; Barrios, A.M.; Woods, V.L.; Neamati, N.; Bottini, N.

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 2011, ISSN: 1535-6108

Sawey, E.T.; Chanrion, M.; Cai, C.; Wu, G.; Zhang, J.; Zender, L.; Zhao, A.; Busutti, R.W.; Yee, H.; Stein, L.; French, D.M.; Finn, R.S.; Lowe, S.W.; Powers, S.

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2011, ISSN: 0022-1759

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.L.; Meng, Y.G.

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies. PHARMACEUTICAL RESEARCH, 2011, V28, N7, JUL, pp 1750-1764. ISSN: 0724-8741.

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NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-alpha Feedforward Signaling Cell, 2011, ISSN: 1097-4172

Biton, Sharon; Ashkenazi, Avi

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime. Analytical Biochemistry, 2011, ISSN: 0003-2697

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FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways. PloS One, 2011, ISSN: 1932-6203

Wu, A.L.; Coulter, S.; Liddle, C.; Wong, A.; Eastham-Anderson, J.; French, D.M.; Peterson, A.S.; Sonoda, J.

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow. PloS One, 2011, ISSN: 1932-6203

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Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449). Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Giannetti, Anthony; Wong, Harvey; Dijkgraaf, Gerrit; Dueber, Erin; Bravo, Brandon; Gould, Stephen; Plise, Emile; Lum, Bert; Malhi, Vikram; Graham, Richard; Ortwine, Daniel

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RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Robert, N.J.; Dieras, V.; Glaspy, J.; Brufsky, A.M.; Bondarenko, I.; Lipatov, O.N.; Perez, E.A.; Yardley, D.A.; Chan, S.Y.T.; Zhou, X.; Phan, S.C.; O'Shaughnessy, J.

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration. Neuron, 2011, ISSN: 0896-6273

Wang, Y.; Li, G.; Stanco, A.; Long, J.E.; Crawford, D.; Potter, G.B.; Pleasure, S.J.; Behrens, T.; Rubenstein, J.L.R.

Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies. Journal of Immunological Methods, 2011, ISSN: 0022-1759

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CD40 Pathway Activation Status Predicts Response to CD40 Therapy in Diffuse Large B Cell Lymphoma. Science Translational Medicine, 2011, ISSN: 1946-6242

Burington, B.; Yue, P.; Shi, X.; Advani, R.; Lau, J.T.; Tan, J.; Stinson, S.; Stinson, J.; Januario, T.; de Vos, S.; Ansell, S.; Forero-Torres, A.; Fedorowicz, G.; Yang, T.T.C.; Elkins, K.; Du, C.; Mohan, S.; Yu, N.; Modrusan, Z.; Seshagiri, S.; Yu, S.F.; Pandita, A.; Koeppen, H.; French, D.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.; Dornan, D.

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes PLoS Genetics, 2011, ISSN: 1553-7390

Taylor, K.E.; Chung, S.A.; Graham, R.R.; Ortmann, W.A.; Lee, A.T.; Langefeld, C.D.; Jacob, C.O.; Kamboh, M.I.; Alarc&oacuten;-Riquelme, M.E., Tsao, B.P.; Moser, K.L.; Gaffney, P.M.; Harley, J.B.; Petri, M.; Manzi, S.; Gregersen, P.K.; Behrens, T.W.; Criswell, L.A.

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 2011, ISSN: 0002-9297

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HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells. Blood, 2011, ISSN: 0006-4971

Favre, D.; Stoddart, C.A.; Emu, B.;Hoh, R.; Martin, J.N.; Hecht, F.M.; Deeks, S.G.; McCune, J.M.

Sensitivity to Anti-Tubulin Chemotherapeutics is regulated by Mcl-1 and FBW7 Nature, 2011, ISSN: 0028-0836

Wertz, Ingrid; Kusam, Saritha; Lam, Cynthia; Okamoto, T.; Sandoval, Wendy; Anderson, D.J.; Helgason, E.; Ernst, James; Eby, M.; Liu, Jinfeng; Belmont, L.D.; Kaminker, Joshua; O'Rourke, Karen; Pujara, Kanan; Kohli, Pawan; Johnson, Adam; Chiu, M.L.; Lill, Jennie; Jackson, P.K.; Fairbrother, Wayne; Seshagiri, Somasekar; Ludlam, M.J.C.; Leong, K.G.; Dueber, E.C.; Maecker, H.; Huang, D.C.S.; Dixit, Vishva

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Benzo[a]pyrene Increases the Nrf2 Content by Downregulating the Keap1 Message. Toxicological Sciences, 2010, ISSN: 1096-6080

Nguyen, P.M.; Park, M.S.; Chow, M.; Chang, J.H.; Wrischnik, L.; Chan, W.K.

Pregnancy outcomes after maternal exposure to rituximab. Blood, 2011, ISSN: 0006-4971

Chakravarty, E.F.; Murray, E.R.; Kelman, A.; Farmer, P.

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening. Drug Metabolism and Disposition, {Drug-Metab-Dispos}, June 2011, vol. 39, no. 6, p. 952-965, 22 refs, CODEN: DMDSA, eISSN: 1521-009X, ISSN: 0090-9556. Publisher: American Society for Pharmacology and Experimental Therapy, 9650 Rockville Pike, Bethesda, MD 20814, USA.

Yue, Qin; Chen, Yung Hsiang; Mulder, Teresa; Deese, Alan; Takahashi, Ryan; Rudewicz, Patrick J; Reynolds, Mark; Solon, Eric; Hop, Cornelis ECA; Wong, Harvey; Khojasteh, S Cyrus

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Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes p450. Drug Metabolism and Disposition, 2011, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PLoS One, 2011, ISSN: 1932-6203

Lee, G.; Origanti, S.; White, L.; Sun, J.; Stappenbeck, T.; Piwnica-Worms, H.

TRAPing a new gene for autoimmunity. Nature Genetics, 2011, ISSN: 1546-1718

Behrens, T.; Graham, R.

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells. Cancer Cell, 2011, ISSN: 1535-6108

Wilson, N.; Yang, B.; Yang, A.; Loeser, S.; Marsters, S.; Lawrence, D.; Li, Y.; Pitti, R.; Totpal, K.; Yee, S.; Ross, S.; Vernes, J.; Lu, Y.; Adams, C.; Offringa, R.; Kelley, B.; Hymowitz, S.; Daniel, D.; Meng, G.; Ashkenazi, A.

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease. Neuron, 2011, ISSN: 1097-4199

Bingol, B.; Sheng, M.

Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary LC-MS. Analytical Biochemistry, 2011, ISSN: 1096-0309

Xu, K.; Liu, L.; Saad, O.; Baudys, J.; Williams, L.; Leipold, D.; Shen, B.; Raab, H.; Junutula, J.; Kim, A.; Kaur, S.

Glucocorticoid-induced Leucine Zipper 1 Stimulates the Epithelial Sodium Channel by Regulating Serum- and Glucocorticoid-induced Kinase 1 Stability and Subcellular Localization. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, ISSN: 0021-9258

Soundararajan, R.; Wang, J.; Melters, D.; Pearce, D.

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Batten, M.; Ramamoorthi, N.; Kljavin, N.; Ma, C.; Cox, J.; Dengler, H.; Danilenko, D.; Caplazi, P.; Wong, M.; Fulcher, D.; Cook, M.; King, C.; Tangye, S.; de Sauvage, F.; Ghilardi, N.

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell, 2011, ISSN: 1878-1551

Koch, A.; Mathivet, T.; Larrivee, B.; Tong, R.; Kowalski, J.; Pibouin-Fragner, L.; Bouvree, K.; Stawicki, S.; Nicholes, K.; Rathore, N.; Scales, S.; Luis, E.; Del, T.; Freitas, C.; Breant, C.; Michaud, A.; Corvol, P.; Thomas, J.; Wu, Y.; Peale, F.; Watts, R.; Tessier-Lavigne, M.; Bagri, A.; Eichmann, A.

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UNCovering the Molecular Machinery of Dependence Receptor Signaling. Molecular Cell, 2010, ISSN: 1097-4164

Bagri, A.; Ashkenazi, A.

Translational Pharmacokinetics and Pharmacodynamics of an FcRn-Variant Anti-CD4 Monoclonal Antibody From Preclinical Model to Phase I Study. Clinical Pharmacology and Therapeutics, 2010, ISSN: 1532-6535

Zheng, Y.; Scheerens, H.; Davis, J.C.; Deng, R.; Fischer, S.K.; Woods, C.; Fielder, P.J.; Stefanich, E.G.

Identification of IgG(1) variants with increased affinity to Fcγ RIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.; Meng, Y.G.

Utility of inter-system extrapolation factors (ISEFs) in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochrome P450s. Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

NFKBIA Deletion in Glioblastomas. New England Journal of Medicine, 2010, ISSN: 1533-4406

Bredel, M.; Scholtens, D.M.; Yadav, A.K.; Alvarez, A.A.; Renfrow, J.J,; Chandler, J.P.; Yu, I.L.; Carro, M.S.; Dai, F.; Tagge, M.J.; Ferrarese, R.; Bredel, C.; Phillips, H.S.; Lukac, P.J.; Robe, P.A.; Weyerbrock, A.; Vogel, H.; Dubner, S.; Mobley, B.; He, X.; Scheck, A.C.; Sikic, B.I.; Aldape, K.D.; Chakravarti, A.; Harsh, G.R.

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After Prior HER2-Directed Therapy. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Burris, H.A.; Rugo, H.S.; Vukelja, S.J.; Vogel, C.L.; Borson, R.A.; Limentani, S.; Tan, C.E.; Krop, I.E.; Michaelson, R.A.; Girish, S.; Amler, L.; Zheng, M.; Chu, Y.W.; Klencke, B.; O'Shaughnessy, J.A.

IL-27 promotes T cell-dependent colitis through multiple mechanisms. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Cox, J.H.; Kljavin, N.M.; Ramamoorthi, N.; Diehl, L.; Batten, M.; Ghilardi, N.

Identification of Isomerization and Racemization of Aspartate in the Asp-Asp Motifs of a Therapeutic Protein. Analytical Biochemistry, 2010, ISSN: 1096-0309

Zhang, J.; Yip, H.; Katta, V.

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets. Immunity, 2010, ISSN: 1074-7613

Palucka, K.; Banchereau, J.; Mellman, I.

Reply to Talloen et al.: Independent filtering is a generic approach that needs domain specific adaptation. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Bourgon, R.; Gentleman, R.; Huber, W.

Identification and functional analysis of endothelial tip cell-enriched genes. Blood, 2010, ISSN: 0006-4971

del Toro, R.; Prahst, C.; Mathivet, T.; Siegfried, G.; Kaminker, J.S.; Larrivee, B,; Breant, C.; Duarte, A.; Takakura, N.; Fukamizu, A.; Penninger, J.; Eichmann, A.

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO Journal, 2010, ISSN: 1460-2075

Dynek, J.N.; Goncharov, T.; Dueber, E.C.; Fedorova, A.V.; Izrael-Tomasevic, A.; Phu, L.; Helgason, E.; Fairbrother, W.J.; Deshayes, K.; Kirkpatrick, D.S.; Vucic, D.

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling. Molecular Cell, 2010, ISSN: 1097-2765

Bosanac, I.; Wertz, I.E.; Pan, B.; Yu, C.; Kusam, S.; Lam, C.; Phu, L.; Phung, Q.; Maurer, B.; Arnott, D.; Kirkpatrick, D.S.; Dixit, V.M.; Hymowitz, S.G.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis Nature Chemical Biology, 2010, ISSN: 1552-4469

Di Paolo, Julie; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai; Bravo, Brandon; Carano, Richard; Darrow, James; Davies, Douglas; DeForge, Laura; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven; Giannetti, Anthony; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah; Jones, Randall; Kropf, Jeffrey; Lee, Wyne; Maciejewski, Patricia; Mitchell, Scott; Rong, Hong; Staker, Bart; Whitney, Andrew; Yeh, Sherry; Young, Wendy; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin

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Unleashing cell death: the Fas-FADD complex. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Hymowitz, S.G.; Dixit, V.M.

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development, 2010, ISSN: 0950-1991

Seidel, K.; Ahn, C.; Lyons, D.; Nee, A.; Ting, K.; Brownell, I.; Cao, T.; Carano, R.; Curran, T.; Schober, M.; Fuchs, E.; Joyner, A.; Martin, G.; de Sauvage, F.; Klein, O.

Regulation of Cytokine Secretion in Human CD127(+) LTi-like Innate Lymphoid Cells by Toll-like Receptor 2. Immunity, 2010, ISSN: 1074-7613

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Satoh, T.N.; DiSanto, J.P.; Spits, H.

Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood, 2010, ISSN: 0006-4971

Jo, S.H.; Schatz, J.H.; Acquaviva, J.; Singh, H.; Ren, R.

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes. Developmental Cell, 2010, ISSN: 1534-5807

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; Baron, R.

Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying. Pharmaceutical Research, 2010, ISSN: 0724-8741

Sundaramurthi, P.; Patapoff, T.W.; Suryanarayanan, R.

Clinical Experience With Hedgehog Pathway Inhibitors. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Low, J.A.; de Sauvage, F.J.

Electrostatic Docking of a Supramolecular Host-Guest Assembly to Cytochrome c Probed by Bidirectional Photoinduced Electron Transfer. Journal of the American Chemical Society, 2010, ISSN: 1520-5126

Jankowska, K.I.; Pagba, C.V.; Piatnitski Chekler, E.L.; Deshayes, K.; Piotrowiak, P.

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genetics, 2010, ISSN: 1061-4036

Otto, E.; Hurd, T.; Airik, R.; Chaki, M.; Zhou, W.; Stoetzel, C.; Patil, S.; Levy, S.; Ghosh, A.; Murga- Zamalloa, C.; van Reeuwijk, J.; Letteboer, S.; Sang, L.; Giles, R.; Liu, Q.; Coene, K.; Estrada-Cuzcano, A.; Collin, R.; McLaughlin, H.; Held, S.; Kasanuki, J.; Ramaswami, G.; Conte, J.; Lopez, I.; Washburn, J.; MacDonald, J.; Hu, J.; Yamashita, Y.; Maher, E.; Guay-Woodford, L.; Neumann, H.; O

Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Khojasteh, S.C.; Oishi, S.; Nelson, S.

Developmental Immunotoxicology Assessment of Rituximab in Cynomolgus Monkeys. Toxicological Sciences, 2010, ISSN: 1096-0929

Vaidyanathan, A.; McKeever, K.; Anand, B.; Eppler, S.; Weinbauer, G.; Beyer, J.

Vegf regulates embryonic erythroid development through Gata1 modulation. Blood, 2010, ISSN: 0006-4971

Drogat, B.; Kalucka, J.; Gutierrez, L.; Hammad, H.; Goossens, S.; Ghahremani, M.F.; Bartunkova, S.; Haigh, K.; Deswarte, K.; Nyabi, O.; Naessens, M.; Ferrara, N.; Klingmueller, U.; Lambrecht, B.; Nagy, A.; Philipsen, S.; Haigh, J.

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood, 2010, ISSN: 0006-4971

Moll, M.; Andersson, S.; Smed-Soerensen, A.; Sandberg, J.

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nature Medicine, 2010, ISSN: 1546-170X

Ferrara, N.

Optimizing Collection of Adverse Event Data in Cancer Clinical Trials Supporting Supplemental Indications. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Kaiser, L.; Melemed, A.; Preston, A.; Chaudri, R.; Hilary, A.; Niedzwiecki, D.; Fyfe, G.; Gough, J.; Bushnell, W.; Stephens, C.; Mace, M.K.; Abrams, J.; Schilsky, R.

Even Neurons Are Excited by Th17 Cells. Immunity, 2010, ISSN: 1097-4180

Egen, J.; Ouyang, W.

Cancer: miRNA Addiction - Depending On Life's Little Things. Current Biology, 2010, ISSN: 1879-0445

Dornan, D.; Settleman, J.

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Zhihua, J.Q.; Ying, Y.; Fox, M.; Peng, K.; Lewin-Koh, S.-C.; Coleman, D.; Good, J.; Lowe, J.; Rahman, A.; Yang, J.; Jiang, J.; Quarmby, V.; Song, A.

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Landgraf, K.E.; Santell, L.; Billeci, K.L.; Quan, C.; Young, J.C.; Maun, H.R.; Kirchhofer, D.; Lazarus, R.A.

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Molecular Biomarker Analyses Using Circulating Tumor Cells PLoS ONE, 2010, ISSN: 1932-6203

Punnoose, E.; Atwal, S.; Spoerke, J.; Savage, H.; Pandita, A.; Yeh, R.-F.; Pirzkall, A.; Fine, B.; Amler, L.; Chen, D.; Lackner, M.

Evaluation of Heterophilic Antibody Blocking Agents in Reducing False Positive Interference in Immunoassays for IL-17AA, IL-17FF, and IL-17AF. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Deforge, L.; Loyet, K.; Delarosa, D.; Chinn, J.; Zamanian, F.; Chuntharapai, A.; Lee, J.; Hass, P.; Wei, N.; Townsend, M.; Wang, J.; Wong, W.L.

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation. Current Opinion in Cell Biology, 2010, ISSN: 1879-0410

Yang, A.; Wilson, N.; Ashkenazi, A.

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies PloS ONE, 2010, ISSN: 1932-6203

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Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer Science Translational Medicine, 2010, ISSN: 1946-6242

Wallin, J.; Guan, J.; Prior, W.-W.; Edgar, K.; Kassees, R.; Sampath, D.; Belvin, M.; Friedman, L.

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Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression. Neuron, 2010, ISSN: 0896-6273

Kuwako, K.; Kakumoto, K.; Imai, T.; Igarashi, M.; Hamakubo, T.; Sakakibara, S.; Tessier-Lavigne, M.; Okano, H.J.; Okano, H.

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

He, Y.; Wortmann, A.; Burke, L.; Reid, J.; Adams, M.; Abdul-Jabbar, I.; Quigley, J.; Leduc, R.; Kirchhofer, D.; Hooper, J.

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Fiorillo, E.; Orru, V.; Stanford, S.; Liu, Y.; Salek, M.; Rapini, N.; Schenone, A.; Saccucci, P.; Delogu, L.; Angelini, F.; Bitti, M.L.M.; Schmedt, C.; Chan, A.C.; Acuto, O.; Bottini, N.

Double TIP-ping. Science, 2010, ISSN: 1095-9203

Singh, H.; Demarco, I.

Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations. PLoS ONE, 2010, ISSN: 1932-6203

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Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature. PLoS ONE, 2010, ISSN: 1932-6203

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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. Journal of Experimental Medicine, 2010, ISSN: 0022-1007

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New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain. Neuron, 2010, ISSN: 0896-6273

Kaneko, N.; Marin, O.; Koike, M.; Hirota, Y.; Uchiyama, Y.; Wu, J.; Lu, Q.; Tessier-Lavigne, M.; Alvarez-Buylla, A.; Okano, H.; Rubenstein, J.; Sawamoto, K.

Manipulation of Host Cell Death Pathways during Microbial Infections. Cell Host & Microbe, 2010, ISSN: 1931-3128

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β-catenin balances immunity. Science, 2010, ISSN: 1095-9203

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Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood, 2010, ISSN: 1528-0020

Dornan, D.; Spleiss, O.; Yeh, R.; Duchateau-Nguyen, G.; Dufour, A.; Zhi, J.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 2010, ISSN: 1476-4687

Kan, Z.; Jaiswal, B.; Stinson, J.; Janakiraman, V.; Bhatt, D.; Stern, H.; Yue, P.; Haverty, P.; Bourgon, R.; Zheng, J.; Moorhead, M.; Chaudhuri, S.; Tomsho, L.; Peters, B.; Pujara, K.; Cordes, S.; Davis, D.; Carlton, V.; Yuan, W.; Li, L.; Wang, W.; Eigenbrot, C.; Kaminker, J.; Eberhard, D.; Waring, P.; Schuster, S.; Modrusan, Z.; Zhang, Z.; Stokoe, D.; de Sauvage, F.; Faham, M.; Seshagiri, S.

Structural basis for high-affinity HER2 receptor binding by an engineered protein. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Eigenbrot, C.; Ultsch, M.; Dubnovitsky, A.; Abrahmsen, L.; Haerd, T.

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nature Genetics, 2010, ISSN: 1546-1718

Ferreira, R.; Pan-Hammarstroem, Q.; Graham, R.; Gateva, V.; Fontan, G.; Lee, A.; Ortmann, W.; Urcelay, E.; Fernandez-Arquero, M.; Nunez, C.; Jorgensen, G.; Ludviksson, B.; Koskinen, S.; Haimila, K.; Clark, H.; Klareskog, L.; Gregersen, P.; Behrens, T.; Hammarstroem, L.

Long live science! Long live the hedgehog! (Vive la science! Vive le herisson!) EMBO Reports, 2010, ISSN: 1469-221X

Reiter, J.; de Sauvage, F.

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nature Immunology, 2010, ISSN: 1529-2908

Hodson, D.; Janas, M.; Galloway, A.; Bell, S.; Andrews, S.; Li, C.; Pannell, R.; Siebel, C.; Mac Donald, H.R.; De Keersmaecker, K.; Ferrando, A.; Grutz, G.; Turner, M.

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody. Molecular Cell, 2010, ISSN: 1097-4164

Matsumoto, M.; Wickliffe, K.; Dong, K.; Yu, C.; Bosanac, I.; Bustos, D.; Phu, L.; Kirkpatrick, D.; Hymowitz, S.; Rape, M.; Kelley, R.; Dixit, V.

Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature Biotechnology, 2010, ISSN: 1087-0156

Domann, P.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusuess, C.; Perrett, D.; Quaglia, M.; Rapp, E.; Smallshaw, L.; Smith, N.; Smyth, W.F.; Taylor, C.

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. New England Journal of Medicine, 2010, ISSN: 0028-4793

Stone, J.; Merkel, P.; Spiera, R.; Seo, P.; Langford, Carol, A.; Hoffman, G.; Kallenberg, C.; St. Clair, E.W.; Turkiewicz, A.; Tchao, N.; Webber, L.; Ding, L.; Sejismundo, L.; Mieras, K.; Weitzenkamp, D.; Ikle, D.; Seyfert-Margolis, V.; Mueller, M.; Brunetta, P.; Allen, N.; Fervenza, F.; Geetha, D.; Keogh, K.; Kissin, E.; Monach, P.; Peikert, T.; Stegeman, C.; Ytterberg, S.; Specks, U.

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

Cao, S.; Yaqoob, U.; Das, A.; Shergill, U.; Jagavelu, K.; Huebert, R.; Routray, C.; Abdelmoneim, S.; Vasdev, M.; Leof, E.; Charlton, M.; Watts, R.; Mukhopadhyay, D.; Shah, V.

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature, 2010, ISSN: 0028-0836

Surolia, I.; Pirnie, S.; Chellappa, V.; Taylor, K.; Cariappa, A.; Moya, J.; Liu, H.; Bell, D.; Driscoll, D.; Diederichs, S.; Haider, K.; Netravali, I.; Le, S.; Elia, R.; Dow, E.; Lee, A.; Freudenberg, J.; De Jager, P.; Chretien, Y.; Varki, A.; MacDonald, M.; Gillis, T.; Behrens, T.; Bloch, D.; Collier, D.; Korzenik, J.; Podolsky, D.; Hafler, D.; Murali, M.; Sands, B.; Stone, J.; Gregersen, P.; Pi

The Tripartite Motif Protein MADD-2 Functions with the Receptor UNC-40 (DCC) in Netrin-Mediated Axon Attraction and Branching. Developmental Cell, 2010, ISSN: 1534-5807

Hao, J.; Adler, C.; Mebane, L.; Gertler, F.; Bargmann, C.; Tessier-Lavigne, M.

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia Cell, 2010, ISSN: 0092-8674

Jin, H.; White, S.R.; Shida, T.; Schulz, S.; Aguiar, M.; Gygi, S.P.; Bazan, J.F.; Nachury, M.V.

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nature Immunology, 2010, ISSN: 1529-2908

Takamatsu, H.; Takegahara, N.; Nakagawa, Y.; Tomura, M.; Taniguchi, M.; Friedel, R.; Rayburn, H.; Tessier-Lavigne, M.; Yoshida, Y.; Okuno, T.; Mizui, M.; Kang, S.; Nojima, S.; Tsujimura, T.; Nakatsuji, Y.; Katayama, I.; Toyofuku, T.; Kikutani, H.; Kumanogoh, A.

Leachables from Saline-Containing IV Bags Can Alter Therapeutic Protein Properties. Pharmaceutical Research, 2010, ISSN: 1573-904X

Chang, J.; Xiao, N.; Zhu, M.; Zhang, J.; Hoff, E.; Russell, S.; Katta, V.; Shire, S.

Role of Myeloid and Other Stromal Cell Types in Tumor Angiogenesis. Blood, 2009, ISSN: 0006-4971


FcRL5 as a Target of Antibody-Drug Conjugates for the Treatment of Multiple Myeloma. Blood, 2009, ISSN: 0006-4971

Polson, A.G.; Zheng, B.; Elkins, K.; Lau, J.; Go, M.A.; Scales, S.J.; Yu, S.F.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

FC-Gamma Receptor (FCGR) 2A and 3A Polymorphisms Do Not Influence the Outcome of Relapsed or Refractory CLL Patients Treated with Rituximab, Fludarabine, and Cyclophosphamide (R-FC) or Fludarabine, and Cyclophosphamide (FC) Alone. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Spleiss, O.; Yeh, R.F.; Duchateau-Nguyen, G.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

The PI3K Inhibitor GDC-0941 Induces Growth Arrest and Apoptosis of Acute Myeloid Leukemia Cells. Blood, 2009, ISSN: 0006-4971

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CD40 Pathway Activation Status Predicts Response to CD40 Targeted Therapy in Diffuse Large b-Cell Lymphoma. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Burington, B.; Yue, P.; Shi, X.; Advani, R.; Yu, N.; Lau, J.T.; Yu, S.F.; De Vos, S.; Ansell, S.M.; Forero-Torres, A.; Modrusan, Z.; Koeppen, H.; Yang, T.; Du, C.; Elkins, K.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.J.

Higher Doses of Rituximab May Be Required for Patients with CLL as Compared to NHL Based On Population Pharmacokinetic (PK) Modeling. Blood, 2009, ISSN: 0006-4971

Li, J.; Zhi, J.; Wenger, M.K.; Valente, N.; Visich, J.

The PI3K Inhibitor GDC-0941 Synergizes with Standard of Care Therapies to Induce Growth Inhibition and Apoptosis of Multiple Myeloma Cells. Blood, 2009, ISSN: 0006-4971

Munugalavadla, V.; Berry, L.; Du, C.; Mariathasan, S.; Slaga, D.; Sun, L.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

O-Fucose Modulates Notch-Controlled Blood Lineage Commitment. American Journal of Pathology, 2010, ISSN: 0002-9440

Yan, Q.; Yao, D.; Wei, L.; Huang, Y.; Myers, J.; Zhang, L.; Xin, W.; Shim, J.; Man, Y.; Petryniak, B.; Gerson, S.; Lowe, J.; Zhou, L.

A mouse knockout library for secreted and transmembrane proteins. Nature Biotechnology, 2010, ISSN: 1546-1696

Tang, T.; Li, L.; Tang, J.; Li, Y.; Lin, W.Y.; Martin, F.; Grant, D.; Solloway, M.; Parker, L.; Ye, W.; Forrest, W.; Ghilardi, N.; Oravecz, T.; Platt, K.; Rice, D.; Hansen, G.; Abuin, A.; Eberhart, D.; Godowski, P.; Holt, K.; Peterson, A.; Zambrowicz, B.; de Sauvage, F.

Caspase-3 Activation via Mitochondria is Required for Long-Term Depression and AMPA Receptor Internalization. Cell, 2010, ISSN: 0092-8674

Li, Z.; Jo, J.; Jia, J.M.; Lo, S.C.; Whitcomb, D.J.; Jiao, S.; Cho, K.; Sheng, M.

The chemical toolbox for monitoring protein fatty acylation and prenylation. Nature Chemical Biology, 2010, ISSN: 1552-4469

Hannoush, R,; Sun, J.

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood, 2010, ISSN: 1528-0020

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Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. Journal of Clinical Investigation, 2010, ISSN: 1558-8238

Brightbill, H.; Jeet, S.; Lin, Z.; Yan, D.; Zhou, M.; Tan, M.; Nguyen, A.; Yeh, S.; Delarosa, D.; Leong, S.; Wong, T.; Chen, Y.; Ultsch, M.; Luis, E.; Ramani, S.; Jackman, J.; Gonzalez, L.; Dennis, M.; Chuntharapai, A.; DeForge, L.; Meng, Y.; Xu, M.; Eigenbrot, C.; Lee, W.; Refino, C.; Balazs, M.; Wu, L.

Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum interference. Journal of Immunological Methods, 2010, ISSN: 0022-1759

McCutcheon, K.; Quarmby, V.; Song, A.

Independent Adjudication of Symptomatic Heart Failure With the Use of Doxorubicin and Cyclophosphamide Followed by Trastuzumab Adjuvant Therapy: A Combined Review of Cardiac Data From the National Surgical Adjuvant Breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Russell, S.; Blackwell, K.; Lawrence, J.; Pippen, J. E. Jr.; Roe, M.; Wood, F.; Paton, V.; Holmgren, E; Mahaffey, K.

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Jones, J.; Kayagaki, N.; Broz, P.; Henry, T.; Newton, K. O'Rourke, K.; Chan, S.; Dong, J.; Qu, Y.; Roose-Girma, M.; Dixit, V.; Monack, D.

Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941 Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Salphati, L.; Wong, H.; Belvin, M.; Bradford, D.; Edgar, K.; Prior, W.; Sampath, D.; Wallin, J.

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Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell, 2010, ISSN: 1535-6108

Noushmehr, H.; Weisenberger, D.J.; Diefes, K.; Phillips, H.S.; Pujara, K.; Berman, B.P.; Pan, F.; Pelloski, C.E.; Sulman, E.P.; Bhat, K.P.; Verhaak, R.G.W.; Hoadley, K.A.; Hayes, D.N.; Perou, C.M.; Schmidt, H.K.; Ding, L.; Wilson, R.K.; Van Den Berg, D.; Shen, H.; Bengtsson, H.; Neuvial, P.; Cope, L.M.; Buckley, J.; Herman, J.G.; Baylin, S.B.; Laird, P.W.; Aldape, K.

The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature, 2010, ISSN: 1476-4687

Lee, W.; Jiang, Z.; Liu, J.; Haverty, P.; Guan, Y.; Stinson, J.; Yue, P.; Zhang, Y.; Pant, K.; Bhatt, D.; Ha, C.; Johnson, S.; Kennemer ,M.; Mohan, S.; Nazarenko, I.; Watanabe, C.; Sparks, A.; Shames, D.; Gentleman, R.; de Sauvage, F.; Stern, H.; Pandita, A.; Ballinger, D.; Drmanac, R.; Modrusan, Z.; Seshagiri, S.; Zhang, Z.

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site Journal of Biological Chemistry, 2010, ISSN: 1083-351X

Maun, H.R.; Wen, X.; Lingel, A.; de Sauvage, F.J.; Lazarus, R.A.; Scales, S.J.; Hymowitz, S.G.

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Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature, 2010, ISSN: 0028-0836

Baranzini, S.; Mudge, J.; van Velkinburgh, J.; Khankhanian, P.; Khrebtukova, I.; Miller, N.; Zhang, L.; Farmer, A.; Bell, C.; Kim, R.; May, G.; Woodward, J.; Caillier, S.; McElroy, J.; Gomez, R.; Pando, M.; Clendenen, L.; Ganusova, E.; Schilkey, F.; Ramaraj, T.; Khan, O.; Huntley, J.; Luo, S.; Kwok, P.; Wu, T.; Schroth, G.; Oksenberg, J.; Hauser, S.; Kingsmore, S.

Signalling lessons from death receptors: the importance of cleavage. Nature Cell Biology, 2010, ISSN: 1476-4679

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Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathogens, 2010, ISSN: 1553-7374

Carlsson, F.; Kim, J.; Dumitru, C.; Barck, K.; Carano, R.; Sun, M.; Diehl, L.; Brown, E.

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Herbst, R.; Eckhardt, S.; Kurzrock, R.; Ebbinghaus, S.; O'Dwyer, P.; Gordon, M.; Novotny, W.; Goldwasser, M.; Tohnya, T.; Lum, B.; Ashkenazi, A. Jubb, A.; Mendelson, D.

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nature Biotechnology, 2010, ISSN: 1546-1696

Singh, M.; Lima, A.; Molina, R.; Hamilton, P.; Clermont, A.; Devasthali, V.; Thompson, J.; Cheng, J.H.; Bou-Reslan, H.; Ho, C.C.K.; Cao, T., Lee, C., Nannini, M.; Fuh, G.; Carano, R.; Koeppen, H.; Yu, R.; Forrest, W.; Plowman, G.; Johnson, Leisa

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Phase I Study of Trastuzumab-DM1, a HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Krop, I.; Beeram, M.; Modi, S.; Jones, S.; Holden, S.; Yu, W.; Girish, S.; Tibbitts, J.; Yi, J.-H.; Sliwkowski, M.; Jacobson, F.; Lutzker, S.; Burris, H.

Bevacizumab and Recurrent Malignant Gliomas: A European Perspective: Reply to W. Wick et al. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Friedman, H.; Prados, M.; Wen, P.; Mikkelsen, T.; Schiff, D.; Abrey, L.; Yung, W.; Paleologos, N.; Nicholas, M.; Jensen, R.; Vredenburgh, J.; Huang, J.; Zheng, M.; Cloughesy, T.

Development of a Two-Part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Jackman, J.; Chen, Y.; Huang, A.; Moffat, B.; Scheer, J.; Leong, S.; Lee, W.; Zhang, J.; Sharma, N.; Lu, Y.; Iyer, S.; Shields, R.; Chiang, N.; Bauer, M.; Waley, D.; Roose-Girma, M.; Vandlen, R.; Yansura, D.; Wu, Y.; Wu, L.

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Functions of Type II Pneumocyte-Derived Vascular Endothelial Growth Factor in Alveolar Structure, Acute Inflammation, and Vascular Permeability. American Journal of Pathology, 2010, ISSN: 0002-9440

Mura, M.; Binnie, M.; Han, B.; Li, C; Andrade, C.; Shiozaki, A.; Zhang, Y.; Ferrara, N.; Hwang, D.; Waddell, T.; Keshavjee, S.; Liu, M.

Genetic Dissection of the Function of Hindbrain Axonal Commissures. PLoS Biology, 2010, ISSN: 1544-9173

Renier, N.; Schonewille, M.; Giraudet, F.; Badura, A.; Tessier-Lavigne, M.; Avan, P.; de Zeeuw, C.; Chedotal, A.

Interplay of Dissolution, Solubility and Non-Sink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor, GDC-0449, in Dogs: An Investigation using Preclinical Studies and Physiologically- Based Pharmacokinetic Modeling Drug Metabolism and Disposition, 2010, ISSN: 0090-9556

Wong, H.; Theil, F.-P; Cui, Y; Marsters, J.; Khojasteh S.C.; Vernillet, L.; La, H.; Song, X.; Wang, H.; Morinello, E.; Deng, Y.; Hop, C.

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Cancer Therapy Reform Science, 2010, ISSN: 0036-8075

Levinson, A.D.

Utility of Influenza Vaccination for Oncology Patients. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Pollyea, D.A.; Brown, J.M.Y.; Horning, S.J.

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Cliogenesis. Science Signaling, 2009, ISSN: 1937-9145

Ashique, A.M.; Choe, Y.; Karlen, M.; May, S.R.; Phamluong, K.; Solloway, M.J.; Ericson, J.; Peterson, S.A.

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma. Cancer Cell, 2010, ISSN: 1878-3686

Chen, R.; Nishimura, M.C.; Bumbaca, S.M.; Kharbanda, S.; Forrest, W.F.; Kasman, I.M.; Greve, J.M.; Soriano, R.H.; Gilmour, L.L.; Rivers, C.S.; Modrusan, Z.; Nacu, S.; Guerrero, S.; Edgar, K.A.; Wallin, J.J.; Lamszus, K.; Westphal, M.; Heim, S.; James, C.D.; VandenBerg, S.R.; Costello, J.F.; Moorefield, S.; Cowdrey, C.J.; Prados, M.; Phillips, H.S.

Rituximab Plus Fludarabine and Cyclophosphamide Prolongs Progression-Free Survival Compared With Fludarabine and Cyclophosphamide Alone in Previously Treated Chronic Lymphocytic Leukemia. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Robak, T.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Geisler, C.H.; Montillo, M.; Zyuzgin, I.; Ganly, P.S.; Dartigeas, C.; Rosta, A.; Maurer, J.; Mendila, M.; Saville, M.W.; Valente, N.; Wenger, M.K.; Moiseev, S.I.

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nature Cell Biology, 2010, ISSN: 1465-7392

Pereg, Y.; Liu, B.; O'Rourke, K.; Sagolla, M.; Dey, A.; Komuves, L.; French, D.; Dixit, V.

Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluroination. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Driscoll, J.P.; Aliagas, I.; Harris, J.J.; Halladay, J.S.; Khatib-Shahidi, S.; Deese, A.; Segraves, N.; Khojasteh-Bakht, S.C.

Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Wong, K.; Valdez, P.; Tan, C.; Yeh, S.; Hongo, J.; Ouyang, W.

Therapeutic antibody targeting of individual Notch receptors. Nature, 2010, ISSN: 1476-4687

Wu, Y.; Cain-Hom, C.; Choy, L.; Hagenbeek, T.J.; de Leon, G.P.; Chen, Y.; Finkle, D.; Venook, R.; Wu, X.; Ridgway, J.; Schahin-Reed, D.; Dow, G.J.; Shelton, A.; Stawicki, S.; Watts, R.J.; Zhang, J.; Choy, R.; Howard, P.; Kadyk, L.; Yan, M.; Zha, J.; Callahan, C.A.; Hymowitz, S.G.; Siebel, C.W.

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Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2). Biochemistry, 2010, ISSN: 1520-4995

Lovitt, B.; Vanderporten, E.C.; Sheng, Z.; Zhu, H.; Drummond, J.; Liu, Y.

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth. Cell, 2010, ISSN: 1097-4172

Bais, C.; Wu, X.; Yao, J.; Yang, S.; Crawford, Y.; McCutcheon, K.; Tan, C.; Kolumam, G.; Vernes, J.M.; Eastham-Anderson, J.; Haughney, P.; Kowanetz, M.; Hagenbeek, T.; Kasman, I.; Reslan, H.B.; Ross, J.; Van Bruggen, N.; Carano, R.A.; Meng, Y.J.; Hongo, J.A.; Stephan, J.P.; Shibuya, M.; Ferrara, N.

An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G. Current Opinion in Structural Biology, 2010, ISSN: 1879-033X

Tesar, D.B.; Bjorkman, P.J.

IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathogens, 2010, ISSN: 1553-7366

Stoddart, C.A.; Keir, M.E.; McCune, J.M.

Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature, 2010, ISSN: 1476-4687

Chung, I.; Akita, R.; Vandlen, R.; Toomre, D.; Schlessinger, J.; Mellman, I.

Characteristics of rhVEGF Release from Topical Hydrogel Formulations. Pharmaceutical Research, 2010, ISSN: 0724-8741

Ji, J.Y.A.; Liu, J.; Shire, S.J.; Kamerzell, T.J.; Hong, S.; Billeci, K.; Shen, Y.; Wang, Y.J.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 2010, ISSN: 1476-4687

Hatzivassiliou, G.; Song, K.; Yen, I.; Brandhuber, B.J.; Anderson, D.J.; Alvarado, R.; Ludlam, M.J.; Stokoe, D.; Gloor, S.L.; Vigers, G.; Morales, T.; Aliagas, I.; Liu, B.; Sideris, S.; Hoeflich, K.P.; Jaiswal, B.S.; Seshagiri, S.; Koeppen, H.; Belvin, M.; Friedman, L.S.; Malek, S.

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Vrljic, M.; Strop, P.; Ernst, J.A.; Sutton, R.B.; Chu, S.; Brunger, A.T.

Mature dendritic cells use endocytic receptors to capture and present antigens. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Platt, C.D.; Ma, J.K.; Chalouni, C.; Ebersold, M.; Bou-Reslan, H.; Carano, R.A.D.; Mellman, I.; Delamarre, L.

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Makhija, S.; Amler, L.; Glenn, D.; Ueland, F.; Gold, M.; Dizon, D.; Paton, V.; Lin, C.; Januario, T.; Ng, K.; Strauss, A.; Kelsey, S.; Sliwkowski, M.; Matulonis, U.

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood, 2010, ISSN: 0006-4971

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Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines. Cell, 2010, ISSN: 0092-8674

Bingol, B.; Wang, C.F.; Arnott, D.; Cheng, D.M.; Peng, J.M.; Sheng, M.

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature, 2010, ISSN: 0028-0836

Tran., T.S.; Rubio, M.E.; Clem, R.L.; Johnson, D.; Case, L.; Tessier-Lavigne, M.; Huganir, R.L.; Ginty, D.D.; Kolodkin, A.L.

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature, 2010, ISSN: 1476-4687

Schwickart, M.; Huang, X.; Lill, J.R.; Liu, J.; Ferrando, R.; French, D.M.; Maecker, H.; O'Rourke, K.; Bazan, F.; Eastham-Anderson, J.; Yue, P.; Dornan, D.; Huang, D.C.; Dixit, V.M.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathlology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization. Analytical Biochemistry, 2010, ISSN: 1096-0309

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ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2010, ISSN: 1528-0020

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Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2+ and possible function in short-term synaptic plasticity. EMBO Journal, 2010, ISSN: 0261-4189

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Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 2009, ISSN: 1553-7366

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The inflammasomes - art. no. e1000510 PLoS Pathogens, 2009, ISSN: 1553-7366

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Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. Journal of Cell Biology, 2010, ISSN: 0021-9525

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Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

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Stromal Cell-Derived Factor-1/CXCL12 Contributes to MMTV-Wnt1 Tumor Growth Involving Gr1+CD11b+ Cells PLoS ONE, 2010, ISSN: 1932-6203

Liu, B.Y.; Soloviev, I.; Chang, P.; Lee, J.; Huang, X.; Zhong, C.; Ferrara, N.; Polakis, P.; Sakanaka, C.

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development. Cell, 2010, ISSN: 0092-8674

Lichtenberger, B.M.; Tan, P.K.; Niederleithner, H.; Ferrara, N.; Petzelbauer, P.; Sibilia, M.

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo. Developmental Cell, 2010, ISSN: 1534-5807

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Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer Journal of Medicinal Chemistry, 2010, ISSN: 1520-4804

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Chronic DLL4 blockade induces vascular neoplasms. Nature, 2010, ISSN: 1476-4687

Yan, M.; Callahan, C.A.; Beyer, J.C.; Allamneni, K.P.; Zhang, G.; Ridgway, J.B.; Niessen, K.; Plowman, G.D.

Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo. PLoS ONE, 2010, ISSN: 1932-6203

Esue, O.; Rupprecht, L.; Sun, S.X.; Wirtz, D.

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Cupedo, T.; Spits, H.

Reconstitution of a Frizzled8.Wnt3a.LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6. Journal of Biological Chemistry, 2010, ISSN: 1083-351X

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Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity. A Validation Study. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

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Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Li, B.; Xi, H.K.; Diehl, L.; Lee, W.P.; Sturgeon, L.; Chinn, J.; DeForge, L.; Kelley, R.F.; Wiesmann, C.; Campagne, M.V.; Sidhu, S.S.

Characterization of oligosaccharides in recombinant tissue plasminogen activator produced in Chinese Hamster Ovary Cells: two decades of analytical technology development. Analytical Chemistry, 2009, ISSN: 0003-2700

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Somatic mutations in p85alpha promote tumorigenesis through Class IA PI3K activation. Cancer Cell, 2009, ISSN: 1878-3686

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Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins - art. no. e1000218. Plos Biology, 2009, ISSN: 1544-9173

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High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions - art. no. e1000696. PLoS Genetics, 2009, ISSN: 1553-7390

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Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors: insight into heterotrimeric IL-1 signaling complexes. Structure, 2009, ISSN: 1878-4186

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Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides. Pharmaceutical Research, 2009, ISSN: 0724-8741

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Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography. Analytical Chemistry, 2009, ISSN: 1520-6882

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Carboxylate-dependent gelation of a monoclonal antibody. Pharmaceutical Research, 2009, ISSN: 0724-8741

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Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science, 2009, ISSN: 0036-8075

Yauch, R.L.; Dijkgraaf, G.J.P.; Alicke, B.; Januario,T.; Ahn, C.P.; Holcomb, T.; Pujara, K.; Stinson, J.; Callahan, C.A.; Tang, T.; Bazan, J.F.; Kan, Z.; Seshagiri, S.; Hann, C.L.; Gould, S.E.; Low, J.A.; Rudin, C.M.; de Sauvage, F.J.

Masking MALT1: the paracaspase's potential for cancer therapy. Journal of Experimental Medicine, 2009, ISSN: 1540-9538

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Formulation and manufacturability of biologics. Current Opinion in Biotechnology, 2009, ISSN: 1879-0429

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Retinoic acid from the meninges regulates cortical neuron generation. Cell, 2009, ISSN: 0092-8674

Siegenthaler, J.A.; Ashique, A.M.; Zarbalis, K.; Patterson, K.P.; Hecht, J.H.; Kane, M.A.; Folias, A.E.; Choe, Y.; May, S.R.; Kume, T.; Napoli, J.L.; Peterson, A.S.; Pleasure, S.J.

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. Journal of Biological Chemistry, 2009, ISSN: 1083-351X

Varfolomeev, E.; Alicke, B.; Elliott, J.M.; Zobel, K.; West, K.; Wong, H.; Scheer, J.M.; Ashkenazi, A.; Gould, S.E.; Fairbrother, W.J.; Vucic, D.

Role of sensitivity analyses in assessing progression-free survival in late-stage oncology trials. Journal of Clinical Oncology, 2009, ISSN: 1527-7755

Bhattacharya, S.; Fyfe, G.; Gray, R.J.; Sargent, D.J.

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110 alpha and are disrupted in oncogenic p85 mutants. Proceedings of the National Academy of Sciences, 2009, ISSN: 0027-8424

Wu, H.Y.; Shekar, S.C.; Flinn, R.J.; El-Sibai, M.; Jaiswal, B.S.; Sen, K.I.; Janakiraman, V.; Seshagiri, S.; Gerfen, G.J.; Girvin, M.E.; Backer, J.M.

Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry. Analytical Chemistry, 2009, ISSN: 1520-6882

Yu, X.C.; Borisov, O.V.; Alvarez, M.; Michels, D.A.; Wang, Y.J.; Ling, V.

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Lee, E.F.; Fedorova, A.; Zobel, K.; Boyle, M.J.; Yang, H.; Perugini, M.A.; Colman, P.M.; Huang, D.C.S.; Deshayes, K.; Fairlie, W.D.

Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Socinski, M.A.; Langer, C.J.; Huang, J.E.; Kolb, M.M.; Compton, P.; Wang, L.; Akerley, W.

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nature Genetics, 2009, ISSN: 1061-4036

Gateva, V.; Sandling, J.K.; Hom, G.; Taylor, K.E.; Chung, S.A.; Sun, X.; Ortmann, W.; Kosoy, R.; Ferreira, R.C.; Nordmark, G.; Gunnarsson, I.; Svenungsson, E.; Padyukov, L.; Sturfelt, G.; Jonsen, A.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Baechler, E.C.; Brown, E.E.; Alarcon, G.S.; Edberg, J.C.; Ramsey-Goldman, R.; McGwin, G.; Reveille, J.D.; Vila, L.M.; Graham, R.R.; et al.

Bi-directional SIFT predicts a subset of activating mutations PLoS ONE, 2009, ISSN: 1932-6203

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Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 2009, ISSN: 1878-4186

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. Journal of Cell Biology, 2009, ISSN: 1540-8140

Lamkanfi, M.; Mueller, J.L.; Vitari, A.C.; Misaghi, S.; Fedorova. A.; Deshayes, K.; Lee, W.P.; Hoffman, H.M.; Dixit, V.M.

Antigen choice in adoptive T-cell therapy of cancer. Current Opinion in Immunology, 2009, ISSN: 0952-7915

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Local guidance of emerging vessel sprouts requires soluble Flt-1 Developmental Cell, 2009, ISSN: 1534-5807

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A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

Gill, H.S.; Tinianow, J.N.; Ogasawara, A.; Flores, J.E.; Vanderbilt, A.N.; Raab, H.; Scheer, J.M.; Vandlen, R.; Williams, S.P.; Marik, J.

Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity. Journal of Immunological Methods, 2009, ISSN: 0022-1759

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. New England Journal of Medicine, 2009, ISSN: 0028-4793

Von Hoff, D.D.; LoRusso, P.M.; Rudin, C.M.; Reddy, J.C.; Yauch, R.L.; Tibes, R.; Weiss, G.J.; Borad, M.J.; Hann, C.L.; Brahmer, J.R.; Mackey, H.M.; Lum, B.L.; Darbonne, W.C.; Marsters, J.C.; de Sauvage, F.J.; Low J.A.

Brief Report: treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. New England Journal of Medicine, 2009, ISSN: 0028-4793

Rudin, C.M.; Hann, C.L.; Laterra, J.; Yauch, R.L.; Callahan, C.A.; Fu, L.; Holcomb, T.; Stinson, J.; Gould, S.E.; Coleman, B.; LoRusso, P.M.; Von Hoff, D.D.; de Sauvage, F.J.; Low, J.A.

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. PLoS ONE, 2009, ISSN:

Blum, G.; Weimer, R.M.; Edgington, L.E.; Adams, W.; Bogyo, M.

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin's lymphoma. Blood, 2009, ISSN: 1528-0020

Dornan, D.; Bennett, F.; Chen, Y.; Dennis, M.; Eaton D.; Elkins, K.; French, D.; Go, M.A.T.; Jack, A.; Junutula, J.R.; Koeppen, H.; Lau, J.; McBride, J.; Rawstron, A.; Shi, X.; Yu, N.; Yu, S.-F.; Yue, P.; Zheng, B.; Ebens, A.; Polson, A.G.

Structural ties between cholesterol transport and morphogen signaling. Cell, 2009, ISSN: 1097-4172

Bazan, J.F.; de Sauvage, F.J.

A highly annotated whole-genome sequence of a Korean individual. Nature, 2009, ISSN: 0028-0836

Kim, J.I.; Ju, Y.S.; Park, H.; Kim, S.; Lee, S.; Yi, J.H.; Mudge, J.; Miller, N.A.; Hong, D.; Bell, C.J.; Kim, H.S.; Chung, I.S.; Lee, W.C.; Lee, J.S.; Seo, S.H.; Yun, J.Y.; Woo, H.N.; Lee, H.; Suh, D.; Lee, S.; Kim, H.J.; Yavartanoo, M.; Kwak, M.; Zheng, Y.; Lee, M.K.; Park, H.; Kim, J.Y.; ... Wu, T.D.; Kim, H.; Yang, K.-S.; ...Kingsmore, S.F.; Seo, J.-S.

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Chung, S.A.; Tian, C.; Taylor, K.E.; Lee, A.T.; Ortmann, W.A.; Hom, G.; Graham, R.R.; Nititham, J.; Kelly, J.A.; Morrisey, J.; Wu, H.; Yin, H.; Alarcon-Riquelme, M.E.; Tsao, B.P.; Harley, J.B.; Gaffney, P.M.; Moser, K.L.; Manzi, S.; Petri, M.; Gregersen, P.K.; Langefeld, C.D.; Behrens, T.W.; Seldin, M.F.; Criswell, L.A.

Investigation of sample preparation artifacts formed during the enzymatic release of N-Linked glycans prior to analysis by capillary electrophoresis. Analytical Chemistry, 2009, ISSN: 0003-2700

Liu, Y.; Salas-Solano, O.; Gennaro, L.A.

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. Journal of Cell Biology, 2009, ISSN: 0021-9525

Farr, G.A.; Hull, M.; Mellman, I.; Caplan, M.J.

FAM29A promotes microtubule amplification via recruitment of the NEDD1-γ-tubulin complex to the mitotic spindle. Journal of Cell Biology, 2008, ISSN:

Zhu, H.; Coppinger, J.A.; Jang, C.Y.; Yates J.R.III; Fang, G.

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Zheng, M.; Huang, J.E.; Friedman, H.S.; Prados, M.; Wen, P.Y.; Mikkelsen, T.; Schiff, D.; Abrey, L.E.; Yung, W.K.; Paleologos, N.; Nicholas, M.K.; Jensen, R.; Vrdenburgh, J.; Cloughesy, T.

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Current Biology, 2009, ISSN: 1879-0445

Endoh-Yamagami, S.; Evangelista, M.; Wilson, D.; Wen, X.; Theunissen, J.-W.; Phamluong, K.; Davis, M.; Scales, S.J.; Solloway, M.J.; de Sauvage, F.J.; Peterson, A.S.

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Leow, C.C.; Wang, B.; Ross, J.; Chan, S.M.; Zha, J.; Carano, R.A.D.; Frantz, G.; Shen, M.M.; deSauvage, F.J.; Gao, W.-Q.

Breaking into bone biology Nature Medicine, 2009, ISSN:

Choi, Y.; Walsh, M.C.; Arron, J.R.

Navigating the deubiquitinating proteome with a CompPASS.[comment]. Cell, 2009, ISSN: 1097-4172

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Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nature Immunology, 2009, ISSN: 1529-2916

Trifari, S.; Kaplan, C.D.; Tran, E.H.; Crellin, N.K.; Spits, H.

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry, 2009, ISSN: 1520-4995

Bourhis, E.; Lingel, A.; Phung, Q.; Fairbrother, W.J.; Cochran, A.G.

Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. Journal of the American Chemical Society, 2009, ISSN: 0002-7863

Burns, N.Z.; Krylova, I.N.; Hannoush, R.N.; Baran, P.S.

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Pickert, G.; Neufert, C.; Leppkes, M.; Zheng, Y.; Wittkopf, N.; Warntjen, M.; Lehr, H.A.; Hirth, S.; Weigmann, B.; Wirtz, S.; Ouyang, W.; Neurath, M.F.; Becker, C.

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Nojiri, M.; Loyet, K.M.; Klenchin, V.A.; Kabachinski, G.; Martin, T.F.J.

IL-33 raises alarm. Immunity, 2009, ISSN: 1097-4180

Lamkanfi, M.; Dixit, V.M.

TSPAN12 regulates retinal vascular development by promoting Norrin but not Wnt-induced FZD4/β-catenin signaling. Cell, 2009, ISSN: 1097-4172

Junge, H.J.; Yang, S.; Burton, J.B.; Paes, K.; Shu, X.; French, D.M.; Costa, M.; Rice, D.S.; Ye, W.

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study. Journal of Immunological Methods, 2009, ISSN: 1872-7905

Loyet, K.M.; Deng, R.; Liang, W.C.; Wu, Y.; Lowman, H.B.; DeForge, L.E.

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The structure of SHH in complex with HHIP reveals a recognition role for the SHH pseudo-active site in signaling Nature Structural & Molecular Biology, 2009, ISSN: 1545-9985

Bosanac, I.; Maun, H.R.; Scales, S.J.; Wen, X.; Lingel, A.; Bazan, J.F.; de Sauvage, F.J.; Hymowitz, S.G.; Lazarus, R.A.

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Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects. Journal of Clinical Pharmacology, 2009, ISSN: 0091-2700

Eley, T.; Luo, F.R.; Agrawal, S.; Sanil, A.; Manning, J.; Li, T.; Blackwood-Chirchir, A.; Bertz, R.

Follicular lymphoma in the United States: First report of the National LymphoCare Study. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

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Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

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The PRL-1149 G/T polymorphism and rheumatoid arthritis susceptibility. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

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Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell, 2009, ISSN: 1934-5909

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Targeted depletion of lymphotoxin-α-expressing TH1 and TH17 cells inhibits autoimmune disease. Nature Medicine, 2009, ISSN: 1078-8956

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A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell, 2009, ISSN: 1097-4172

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Combined targeting of BRAF and CRAF or BRAF and P13K effector pathways is required for efficacy in NRAS mutant tumors. PloS ONE, 2009, ISSN: 1932-6203

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Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathogens, 2009, ISSN: 1553-7374

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Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

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Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell, 2009, ISSN: 1535-6108

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An analytical system for the characterization of highly heterogeneous mixtures of N-linked oligosaccharides. Analytical Biochemistry, 2009, ISSN: 1096-0309

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How can we improve the translational landscape for a faster cure of type 1 diabetes? Journal of Clinical Investigation, 2009, ISSN: 0021-9738

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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice Journal of Clinical Investigation, 2009, ISSN: 1558-8238

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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development, 2009, ISSN: 0950-1991

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The art of making an exit. Science, 2009, ISSN: 1095-9203

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Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as a first-line treatment of metastatic colorectal cancer: results of the TREE study Journal of Clinical Oncology, 2008, ISSN: 0732-183X

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Role of P-glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents. Drug Metabolism and Disposition, 2008, ISSN: 0090-9556

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Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chemical Biology, 2009, ISSN: 1552-4469

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Death receptor signal transducers: nodes of coordination in immune signaling networks Nature Immunology, 2009, ISSN: 1529-2916

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Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis Journal of Cell Biology, 2009, ISSN: 0021-9525

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Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population Arthritis & Rheumatism, 2009, ISSN: 0004-3591

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Genetic deletion of JAM-C reveals a role in myeloid progenitor generation. Blood, 2009, ISSN: 1528-0020

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A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation Analytical Biochemistry, 2009, ISSN: 1096-0309

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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site Science, 2009, ISSN: 0036-8075

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Fatal hepatitis mediated by tumor necrosis factor TNFα requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity, 2009, ISSN: 1074-7613

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature, 2009, ISSN: 0028-0836

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GPS navigation of the protein-stability landscape. Nature Biotechnology, 2009, ISSN: 1087-0156

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Polar localization of virulence-related Esx-1 secretion in mycobacteria. PLoS Pathogens, 2009, ISSN: 1553-7374

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Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

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Distinct thresholds govern Myc's biological output In Vivo Cancer Cell, 2008, ISSN: 1535-6108

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Trace level analysis of leached Protein A in bioprocess samples without interference from the large excess of rhMAb IgG Journal of Immunological Methods, 2009, ISSN: 0022-1759

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Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

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Automated de novo sequencing of monoclonal antibodies Nature Biotechnology, 2008, ISSN: 1087-0156

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The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

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A specificity map for the PDZ domain family. PLoS Biology, 2008, ISSN: 1544-9173

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A BBSome subunit links ciliogenesis, microtubule stability, and acetylation Developmental Cell, 2008, ISSN: 1534-5807

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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells Nature Immunology, 2009, ISSN: 1529-2908

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PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell, 2009, ISSN: 1535-6108

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Formation of the blood-brain barrier: Wnt signaling seals the deal. Journal of Cell Biology, 2008, ISSN: 1540-8140

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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells Nature Immunology, 2009, ISSN: 1529-2916

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Generation of a prostate from a single adult stem cell Nature, 2008, ISSN: 0028-0836

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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class IPI3 kinase for the treatment of cancer Journal of Medicinal Chemistry, 2008, ISSN: 0022-2623

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents Journal of Cell Biology, 2008, ISSN: 0021-9525

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The hunt for cyclin Cell, 2008, ISSN: 1097-4172

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Stopping replication, at the beginning Nature Chemical Biology, 2008, ISSN: 1552-4450

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Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression Journal of Biological Chemistry, 2008, ISSN: 0021-9258

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB Activation. Journal of Biological Chemistry, 2008, ISSN: 0021-9258

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A paracrine requirement for hedgehog signalling in cancer. Nature, 2008, ISSN: 1476-4687

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Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nature Genetics, 2008, ISSN: 1061-4036

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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus Nature Genetics, 2008, ISSN: 1061-4036

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Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg Blood, 2008, ISSN: 0006-4971

Kim, D.D.; Miwa, T.; Kimura, Y.; Schwendener, R.A.; van Lookeren Campagne, M,V.; Song, W.C.

PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science, 2008, ISSN: 1095-9203

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell, 2008, ISSN: 1097-4172

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The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC. Molecular Cell, 2008, ISSN: 1097-2765

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Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). Journal of Clinical Oncology, 2008, ISSN: 1527-7755

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The unique N-terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances spindle checkpoint regulation of the APC Molecular Cell, 2008, ISSN: 1097-4164

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to late-stage autophagy inhibition Journal of Cell Biology, 2008, ISSN: 1540-8140

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A pentacyclic Aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of Medicinal Chemistry, 2008, ISSN: 1520-4804

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Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos Development, 2008, ISSN: 0950-1991

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Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay. Journal of Immunological Methods, 2008, ISSN: 0022-1759

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Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. Journal of Immunological Methods, 2008, ISSN: 0022-1759

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Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling. PLoS ONE, 2008, ISSN: 1932-6203

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The biological functions of T helper 17 cell effector cytokines in inflammation Immunity, 2008, ISSN: 1074-7613

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Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107 Journal of Clinical Oncology, 2008, ISSN: 0732-183X

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Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody. Analytical Chemistry, 2008, ISSN: 0003-2700

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VEGF inhibition and renal thrombotic microangiopathy New England Journal of Medicine, 2008, ISSN: 0028-4793

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Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study Journal of Clinical Oncology, 2008, ISSN: 0732-183X

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Private lives: reflections and challenges in understanding the cell biology of the immune system. Science, 2007, ISSN: 1095-9203

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Probing cellular systems with chemistry. Nature Chemical Biology, 2007, ISSN: 1552-4450

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Putting transcription repression and protein destruction in pRb's pocket. Developmental Cell, 2007, ISSN: 1534-5807

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The inhibitor of apoptosis protein fusion c-IAP2-MALT1 stimulates NF-κB activation independently of TRAF1 and TRAF2. Journal of Biological Chemistry, 2006, ISSN: 0021-9258

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A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection. Journal of Immunological Methods, 2006, ISSN: 0022-1759

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Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1: Insights into determinants of PDZ domain specificity Journal of Biological Chemistry, 2006, ISSN: 0021-9258

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