Genentech - A Member of the Roche Group

/ Scientists

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

839 results

Title
In Search of Magic Bullets: The Golden Age of Immunotherapeutics Cell, 2014, ISSN: 0092-8674

O'Shea, John J; Kanno, Yuka; Chan, Andrew C

View on PubMed
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling Nature, 2014, ISSN: 0028-0836

Nakamura, Norihiro; Lill, Jennie R; Phung, Qui; Jiang, Zhaoshi; Bakalarski, Corey; de Mazière, Ann; Klumperman, Judith; Schlatter, Megan; Delamarre, Lélia; Mellman, Ira

View on PubMed
Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice Drug Metabolism and Disposition, 2014, ISSN: 0090-9556

Chang, Jae H; Ly, Justin; Plise, Emile; Zhang, Xiaolin; Messick, Kirsten; Wright, Matthew; Cheong, Jonathan

View on PubMed
Next Generation MUT-MAP, a High-Sensitivity High-Throughput Microfluidics Chip-Based Mutation Analysis Panel PloS one, 2014, ISSN: 1932-6203

Schleifman, Erica B; Tam, Rachel; Patel, Rajesh; Tsan, Alison; Sumiyoshi, Teiko; Fu, Ling; Desai, Rupal; Schoenbrunner, Nancy; Myers, Thomas W; Bauer, Keith; Smith, Edward; Raja, Rajiv

View on PubMed
SERPINs shelter the endowed migrants in a hostile land EMBO Journal, 2014, ISSN: 0261-4189

Ye, Weilan

View on PubMed
Elucidating the Mechanism of Cytochrome P450-Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats Drug Metabolism and Disposition, 2014, ISSN: 0090-9556

Takahashi, Ryan H; Ma, Shuguang; Deese, Alan; Yue, Qin; Kim-Kang, Heasook; Yi, Yijun; Siu, Mike; Hunt, Kevin W; Kallan, Nicholas C; Hop, Cornelis E; Liu, Xingrong; Khojasteh, Siamak Cyrus

View on PubMed
Multiplexed ion beam imaging of human breast tumors Nature Medicine, 2014, ISSN: 1078-8956

Angelo, Michael; Bendall, Sean C; Finck, Rachel; Hale, Matthew B; Hitzman, Chuck; Borowsky, Alexander D; Levenson, Richard M; Lowe, John B; Liu, Scot D; Zhao, Shuchun; Natkunam, Yasodha; Nolan, Garry P

View on PubMed
Method for cellular imaging of palmitoylated proteins with clickable probes and proximity ligation applied to hedgehog, tubulin, and ras Journal of the American Chemical Society, 2014, ISSN: 0002-7863

Gao, Xinxin; Hannoush, Rami N

View on PubMed
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4 + T cells Proceedings of the National Academy of Sciences, 2014, ISSN: 0027-8424

Altin, John A.; Daley, Stephen R.; Howitt, Jason; Rickards, Helen J.; Batkin, Alison K.; Horikawa, Keisuke; Prasad, Simon J.; Nelms, Keats A.; Kumar, Sharad; Wu, Lawren C.; Tan, Seong-Seng; Cook, Matthew C.; Goodnow, Christopher C.

View on PubMed
Is SIRT2 required for necroptosis? Nature, 2014, ISSN: 0028-0836

Newton, Kim; Hildebrand, Joanne M; Shen, Zhirong; Rodriguez, Diego; Alvarez-Diaz, Silvia; Petersen, Sean; Shah, Saumil; Dugger, Debra L; Huang, Chunzi; Auwerx, Johan; Vandenabeele, Peter; Green, Douglas R; Ashkenazi, Avi; Dixit, Vishva M; Kaiser, William J; Strasser, Andreas; Degterev, Alexei; Silke, John

View on PubMed
Clinical Validation of a PCR Assay for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer: Retrospective Testing of Specimens from the EURTAC Trial PLoS ONE, 2014, ISSN: 1932-6203

Benlloch, Susana; Botero, Maria Luisa; Beltran-Alamillo, Jordi; Mayo, Clara; Gimenez-Capitán, Ana; de Aguirre, Itziar; Queralt, Cristina; Ramirez, Jose Luis; Cajal, Santiago Ramón Y; Klughammer, Barbara; Schlegel, Mariette; Bordogna, Walter; Chen, David; Zhang, Guili; Kovach, Barbara; Shieh, Felice; Palma, John F; Wu, Lin; Lawrence, H Jeffrey; Taron, Miquel

View on PubMed
Activity of Protein Kinase RIPK3 Determines whether Cells Die by Necroptosis or Apoptosis Science, 2014, ISSN: 0036-8075

Newton, Kim; Dugger, Debra L; Wickliffe, Katherine E; Kapoor, Neeraj; Cristina de-Almagro, M; Vucic, Domagoj; Komuves, Laszlo; Ferrando, Ronald E; French, Dorothy M; Webster, Joshua; Roose-Girma, Merone; Warming, Søren; Dixit, Vishva M

View on PubMed
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3 Nature, 2014, ISSN: 0028-0836

Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; Devoss, Jason; Diehl, Lauri; Graham, Robert R; van Lookeren Campagne, Menno

View on PubMed
1-Aminobenzotriazole (ABT) Co-Incubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9 Drug Metabolism and Disposition, 2014, ISSN: 0090-9556

Sodhi, Jasleen K; Ford, Kevin A; Mukadam, Sophie; Wong, Susan; Hop, Cornelis E C A; Khojasteh, S Cyrus; Halladay, Jason S

View on PubMed
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging Nature, 2014, ISSN: 1476-4687

Ritsma, Laila; Ellenbroek, Saskia I J; Zomer, Anoek; Snippert, Hugo J; de Sauvage, Frederic J; Simons, Benjamin D; Clevers, Hans; van Rheenen, Jacco

View on PubMed
Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors Cell, 2014, ISSN: 0092-8674

Croci, Diego O; Cerliani, Juan P; Dalotto-Moreno, Tomas; Méndez-Huergo, Santiago P; Mascanfroni, Ivan D; Dergan-Dylon, Sebastián; Toscano, Marta A; Caramelo, Julio J; García-Vallejo, Juan J; Ouyang, Jing; Mesri, Enrique A; Junttila, Melissa R; Bais, Carlos; Shipp, Margaret A; Salatino, Mariana; Rabinovich, Gabriel A

View on PubMed
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study The lancet oncology, 2014, ISSN: 1470-2045

McArthur, Grant A; Chapman, Paul B; Robert, Caroline; Larkin, James; Haanen, John B; Dummer, Reinhard; Ribas, Antoni; Hogg, David; Hamid, Omid; Ascierto, Paolo A; Garbe, Claus; Testori, Alessandro; Maio, Michele; Lorigan, Paul; Lebbé, Celeste; Jouary, Thomas; Schadendorf, Dirk; O'Day, Stephen J; Kirkwood, John M; Eggermont, Alexander M; Dréno, Brigitte; Sosman, Jeffrey A; Flaherty, Keith T; Yin, Ming; Caro, Ivor; Cheng, Suzanne; Trunzer, Kerstin; Hauschild, Axel

View on PubMed
The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria Immunity, 2014, ISSN: 1074-7613

Behnsen, Judith; Jellbauer, Stefan; Wong, Christina P; Edwards, Robert A; George, Michael D; Ouyang, Wenjun; Raffatellu, Manuela

View on PubMed
Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis Science Translational Medicine, 2014, ISSN: 1946-6234

Perera, Gayathri K.; Ainali, Chrysanthi; Semenova, Ekaterina; Hundhausen, Christian; Barinaga, Guillermo; Kassen, Deepika; Williams, Andrew E.; Mirza, Muddassar M.; Balazs, Mercedesz; Wang, Xiaoting; Rodriguez, Robert Sanchez; Alendar, Andrej; Barker, Jonathan; Tsoka, Sophia; Ouyang, Wenjun; Nestle, Frank O.

View on PubMed
Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers PLoS ONE, 2014, ISSN: 1932-6203

Schleifman, Erica B; Desai, Rupal; Spoerke, Jill M; Xiao, Yuanyuan; Wong, Cheryl; Abbas, Ilma; O'Brien, Carol; Patel, Rajesh; Sumiyoshi, Teiko; Fu, Ling; Tam, Rachel N; Koeppen, Hartmut; Wilson, Timothy R; Raja, Rajiv; Hampton, Garret M; Lackner, Mark R

View on PubMed
Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication PLoS ONE, 2014, ISSN: 1932-6203

Degtyarev, Michael; Reichelt, Mike; Lin, Kui

View on PubMed
Th17 cells at the crossroads of autoimmunity, inflammation, and atherosclerosis Immunity, 2014, ISSN: 1097-4180

van Bruggen, Nicholas; Ouyang, Wenjun

View on PubMed
Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Staben, Steven T; Feng, Jianwen A; Lyle, Karen; Belvin, Marcia; Boggs, Jason; Burch, Jason D; Chua, Ching-Ching; Cui, Haifeng; Dipasquale, Antonio G; Friedman, Lori S; Heise, Christopher; Koeppen, Hartmut; Kotey, Adrian; Mintzer, Robert; Oh, Angela; Roberts, David Allen; Rouge, Lionel; Rudolph, Joachim; Tam, Christine; Wang, Weiru; Xiao, Yisong; Young, Amy; Zhang, Yamin; Hoeflich, Klaus P

View on PubMed
Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Giannetti, Anthony M; Zheng, Xiaozhang; Skelton, Nicholas J; Wang, Weiru; Bravo, Brandon J; Bair, Kenneth W; Baumeister, Timm; Cheng, Eric; Crocker, Lisa; Feng, Yezhen; Gunzner-Toste, Janet; Ho, Yen-Ching; Hua, Rongbao; Liederer, Bianca M; Liu, Yongbo; Ma, Xiaolei; O'Brien, Thomas; Oeh, Jason; Sampath, Deepak; Shen, Youming; Wang, Chengcheng; Wang, Leslie; Wu, Hongxing; Xiao, Yang; Yuen, Po-Wai; Zak, Mark; Zhao, Guiling; Zhao, Qiang; Dragovich, Peter S

View on PubMed
Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions New England Journal of Medicine, 2014, ISSN: 1533-4406

Goede, Valentin; Fischer, Kirsten; Busch, Raymonde; Engelke, Anja; Eichhorst, Barbara; Wendtner, Clemens M; Chagorova, Tatiana; de la Serna, Javier; Dilhuydy, Marie-Sarah; Illmer, Thomas; Opat, Stephen; Owen, Carolyn J; Samoylova, Olga; Kreuzer, Karl-Anton; Stilgenbauer, Stephan; Döhner, Hartmut; Langerak, Anton W; Ritgen, Matthias; Kneba, Michael; Asikanius, Elina; Humphrey, Kathryn; Wenger, Michael; Hallek, Michael

View on PubMed
Discovery of 7-Tetrahydropyran-2-yl Chromans: beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) inhibitors That Reduce Amyloid beta-Protein (A beta) in the Central Nervous System Journal of Medicinal Chemistry, 2014, ISSN: 0022-2623

Thomas, Allen A.; Hunt, Kevin W.; Volgraf, Matthew; Watts, Ryan J.; Liu, Xingrong; Vigers, Guy; Smith, Darin; Sammond, Douglas; Tang, Tony P.; Rhodes, Susan P.; Metcalf, Andrew T.; Brown, Karin D.; Otten, Jennifer N.; Burkard, Michael; Cox, April A.; Do, Mary K. Geck; Dutcher, Darrin; Rana, Sumeet; DeLisle, Robert K.; Regal, Kelly; Wright, Albion D.; Groneberg, Robert; Scearce-Levie, Kimberly; Siu, Michael; Purkey, Hans E.; Lyssikatos, Joseph P.; Gunawardana, Indrani W.

View on PubMed
Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor PLoS ONE, 2014, ISSN: 1932-6203

Haddick, Patrick C G; Tom, Irene; Luis, Elizabeth; Quiñones, Gabriel; Wranik, Bernd J; Ramani, Sree R; Stephan, Jean-Philippe; Tessier-Lavigne, Marc; Gonzalez, Lino C

View on PubMed
Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib Drug Metabolism and Disposition, 2014, ISSN: 0090-9556

Khojasteh, Siamak Cyrus; Yue, Qin; Ma, Shuguang; Castanedo, Georgette; Chen, Jacob Z; Lyssikatos, Joseph; Mulder, Teresa; Takahashi, Ryan; Ly, Justin; Messick, Kirsten; Jia, Wei; Liu, Lichuan; Hop, Cornelis E C A; Wong, Harvey

View on PubMed
Therapeutic opportunities of the IL-22-IL-22R1 system Nature Reviews, 2013, ISSN: 1474-1776

Sabat, Robert; Ouyang, Wenjun; Wolk, Kerstin

View on PubMed
EBI2 Is a Negative Regulator of Type I Interferons in Plasmacytoid and Myeloid Dendritic Cells PLoS ONE, 2013, ISSN: 1932-6203

Chiang, Eugene Y; Johnston, Robert J; Grogan, Jane L

View on PubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery Nature, 2013, ISSN: 0028-0836

Okada, Yukinori; Wu, Di; Trynka, Gosia; Raj, Towfique; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Yoshida, Shinji; Graham, Robert R; Manoharan, Arun; Ortmann, Ward; Bhangale, Tushar; Denny, Joshua C; Carroll, Robert J; Eyler, Anne E; Greenberg, Jeffrey D; Kremer, Joel M; Pappas, Dimitrios A; Jiang, Lei; Yin, Jian; Ye, Lingying; Su, Ding-Feng; Yang, Jian; Xie, Gang; Keystone, Ed; Westra, Harm-Jan; Esko, Tõnu; Metspalu, Andres; Zhou, Xuezhong; Gupta, Namrata; Mirel, Daniel; Stahl, Eli A; Diogo, Dorothée; Cui, Jing; Liao, Katherine; Guo, Michael H; Myouzen, Keiko; Kawaguchi, Takahisa; Coenen, Marieke J H; van Riel, Piet L C M; van de Laar, Mart A F J; Guchelaar, Henk-Jan; Huizinga, Tom W J; Dieudé, Philippe; Mariette, Xavier; Louis Bridges Jr, S; Zhernakova, Alexandra; Toes, Rene E M; Tak, Paul P; Miceli-Richard, Corinne; Bang, So-Young; Lee, Hye-Soon; Martin, Javier; Gonzalez-Gay, Miguel A; Rodriguez-Rodriguez, Luis; Rantapää-Dahlqvist, Solbritt; Arl

View on PubMed
Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele PLoS ONE, 2013, ISSN: 1932-6203

Kauder, Steven E.; Santell, Lydia; Mai, Elaine; Wright, Lilyan Y.; Luis, Elizabeth; N'Diaye, Elsa N; Lutman, Jeff; Ratti, Navneet; Sa, Susan M.; Maun, Henry R.; Stefanich, Eric; Gonzalez, Lino C.; Graham, Robert R.; Diehl, Lauri; Faubion Jr., William A.; Keir, Mary E.; Young, Judy; Chaudhuri, Amitabha; Lazarus, Robert A.; Egen, Jackson G.

View on PubMed
Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation Nature Immunology, 2013, ISSN: 1529-2908

Vander Lugt, Bryan; Khan, Aly A; Hackney, Jason A; Agrawal, Smita; Lesch, Justin; Zhou, Meijuan; Lee, Wyne P; Park, Summer; Xu, Min; Devoss, Jason; Spooner, Chauncey J; Chalouni, Cecile; Delamarre, Lelia; Mellman, Ira; Singh, Harinder

View on PubMed
Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors Journal of medicinal chemistry, 2014, ISSN: 0022-2623

Estrada, Anthony A; Chan, Bryan K; Baker-Glenn, Charles; Beresford, Alan; Burdick, Daniel J; Chambers, Mark; Chen, Huifen; Dominguez, Sara L; Dotson, Jennafer; Drummond, Jason; Flagella, Michael; Fuji, Reina; Gill, Andrew; Halladay, Jason; Harris, Seth F; Heffron, Timothy P; Kleinheinz, Tracy; Lee, Donna W; Pichon, Claire E Le; Liu, Xingrong; Lyssikatos, Joseph P; Medhurst, Andrew D; Moffat, John G; Nash, Kevin; Scearce-Levie, Kimberly; Sheng, Zejuan; Shore, Daniel G; Wong, Susan; Zhang, Shuo; Zhang, Xiaolin; Zhu, Haitao; Sweeney, Zachary K

View on PubMed
Lgr5(+) Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration Cell stem cell, 2013, ISSN: 1934-5909

Metcalfe, Ciara; Kljavin, Noelyn M; Ybarra, Ryan; de Sauvage, Frederic J

View on PubMed
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Simonetti, Giorgia; Carette, Amanda; Silva, Kathryn; Wang, Haowei; De Silva, Nilushi S.; Heise, Nicole; Siebel, Christian W.; Shlomchik, Mark J.; Klein, Ulf

View on PubMed
PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic kras Science Signaling, 2013, ISSN: 1945-0877

Diaz-Flores, Ernesto; Goldschmidt, Hana; Depeille, Philippe; Ng, Victor; Akutagawa, Jon; Krisman, Kimberly; Crone, Michael; Burgess, Michael R.; Williams, Olusegun; Houseman, Benjamin; Shokat, Kevan; Sampath, Deepak; Bollag, Gideon; Roose, Jeroen P.; Braun, Benjamin S.; Shannon, Kevin

View on PubMed
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine Nature Chemical Biology, 2013, ISSN: 1552-4450

Gao, Xinxin; Hannoush, Rami

View on PubMed
Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Sudhamsu, Jawahar; Yin, Jianping; Chiang, Eugene Y; Starovasnik, Melissa A; Grogan, Jane L; Hymowitz, Sarah G

View on PubMed
Dimerization of LT beta R by LT alpha(1)beta(2) is necessary and sufficient for signal transduction Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Sudhamsu, Jawahar; Yin, JianPing; Chiang, Eugene Y.; Starovasnik, Melissa A.; Grogan, Jane L.; Hymowitz, Sarah G.

View on PubMed
Identification of a small peptide that inhibits PCSK9 binding to the low density lipoprotein receptor Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Zhang, Yingnan; Eigenbrot, Charles; Zhou, Lijuan; Shia, Steven; Li, Wei; Quan, Clifford; Tom, Jeffrey; Moran, Paul; Di Lello, Paola; Skelton, Nicholas; Beltran, Monica; Peterson, Andrew; Kirchhofer, Daniel

View on PubMed
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Kirkpatrick, Donald S; Bustos, Daisy J; Dogan, Taner; Chan, Jocelyn; Phu, Lilian; Young, Amy; Friedman, Lori S; Belvin, Marcia; Song, Qinghua; Bakalarski, Corey E; Hoeflich, Klaus P

View on PubMed
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo Journal of Experimental Medicine, 2013, ISSN:

Abdel-Wahab O; Gao J; Adli M; Dey A; Trimarchi T; Chung YR; Kuscu C; Hricik T; Ndiaye-Lobry D; Lafave LM; Koche R; Shih AH; Guryanova OA; Kim E; Li S; Pandey S; Shin JY; Telis L; Liu J; Bhatt PK; Monette S; Zhao X; Mason CE; Park CY; Bernstein BE; Aifantis I; Levine RL.

View on PubMed
The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199 Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Choo, Edna F; Boggs, Jason; Zhu, Chunqiang; Lubach, Joseph W; Catron, Nathaniel D; Jenkins, Gary; Souers, Andrew; Voorman, Richard

View on PubMed
A Nobel Prize for membrane traffic: Vesicles find their journey's end Journal of Cell Biology, 2013, ISSN: 0021-9525

Mellman, Ira; Emr, Scott D

View on PubMed
Modulating caspase activity: beyond the active site Current Opinion in Structural Biology, 2013, ISSN: 0959-440X

Murray, Jeremy; Renslo, Adam R

View on PubMed
Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin Neuron, 2013, ISSN: 0896-6273

Yang, Jing; Weimer, Robby M; Kallop, Dara; Olsen, Olav; Wu, Zhuhao; Renier, Nicolas; Uryu, Kunihiro; Tessier-Lavigne, Marc

View on PubMed
Improved Crystallographic Structures Using Extensive Combinatorial Refinement Structure, 2013, ISSN:

Nwachukwu, Jerome; Southern, Mark; Kiefer, James; Afonine, Pavel; Adams, Paul; Terwilliger, Thomas; Nettles, Kendall

View on PubMed
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Susmith Mukund; Yonglei Shang; Holly J Clarke; Azadeh Madjidi; Jacob E Corn; Lance Kates; Ganesh Kolumam; Vicki Chiang; Elizabeth Luis; Jeremy Murray; Yingnan Zhang; Isidro Hötzel; Christopher M Koth; Bernard B Allan

View on PubMed
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Pozniak, Christine; Sengupta Ghosh, Arundhati; Gogineni, Alvin; Hanson, Jesse; Lee, Seung-Hye; Larson, Jessica; Solanoy, Hilda; Bustos, Daisy; Li, Hong; Ngu, Hai; Jubb, Adrian; Ayalon, Gai; Wu, Jiansheng; Scearce-Levie, Kimberly; Zhou, Qiang; Weimer, Robby; Kirkpatrick, Donald; Lewcock, Joseph

View on PubMed
Inhibition of the p110 alpha isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Soler, Adriana; Serra, Helena; Pearce, Wayne; Angulo, Ana; Guillermet-Guibert, Julie; Friedman, Lori S.; Vinals, Francesc; Gerhardt, Holger; Casanovas, Oriol; Graupera, Mariona; Vanhaesebroeck, Bart

View on PubMed
Delta-like notch ligands expressed by host non-hematopoietic radioresistant cells regulate graft-versus-host disease and extrathymic T cell development after bone marrow transplantation Blood, 2013, ISSN: 0006-4971

Ebens, Christen L.; Chung, Jooho; Koch, Ute; Tran, Ivy T.; Sandy-Sloat, Ashley R.; Friedman, Ann; Blazar, Bruce R.; Reddy, Pavan; Yan, Minhong; Siebel, Christian W.; Radtke, Freddy; Maillard, Ivan

Early relapse of follicular lymphoma after R-CHOP uniquely defines patients at high risk for death: An analysis from the national lymphocare study Blood, 2013, ISSN: 0006-4971

Casulo, Carla; Byrtek, Michelle; Dawson, Keith L.; Zhou, Xiaolei; Farber, Charles; Flowers, Christopher R.; Hainsworth, John D.; Link, Brian K.; Zelenetz, Andrew D.; Friedberg, Jonathan W.

Differences in treatment patterns and costs among diffuse large B-cell lymphoma patients treated in the clinic Vs. the hospital outpatient setting Blood, 2013, ISSN: 0006-4971

Reyes, Carolina; Dacosta Byfield, Stacey; Becker, Laura K.; Small, Art

Characterizing the CPG methylation of epstein-barr virus DNA in the plasma of patients with hodgkin lymphoma and HIV-associated burkitt lymphoma Blood, 2013, ISSN: 0006-4971

Kanakry, Jennifer A.; Shamay, Meir; Kasamon, Yvette L.; Li, Hailun; Gascoyne, Randy D.; Gordon, Leo I.; Noy, Ariela; Cesarman, Ethel; Lee, Jeannette Y.; Horning, Sandra J.; Ambinder, Richard F.

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1 Nature Immunology, 2013, ISSN: 1529-2908

Spooner, Chauncey J; Lesch, Justin; Yan, Donghong; Khan, Aly A; Abbas, Alex; Ramirez-Carrozzi, Vladimir; Zhou, Meijuan; Soriano, Robert; Eastham-Anderson, Jeffrey; Diehl, Lauri; Lee, Wyne P; Modrusan, Zora; Pappu, Rajita; Xu, Min; Devoss, Jason; Singh, Harinder

View on PubMed
Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Boswell, C. Andrew; Marik, Jan; Elowson, Michael J.; Reyes, Noe A.; Ulufatu, Sheila; Bumbaca, Daniela; Yip, Victor; Mundo, Eduardo E.; Majidy, Nicholas; Van Hoy, Marjie; Goriparthi, Saritha N.; Trias, Anthony; Gill, Herman S.; Williams, Simon P.; Junutula, Jagath R.; Fielder, Paul J.; Khawli, Leslie A.

View on PubMed
Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins PLoS Pathogens, 2013, ISSN: 1553-7366

Hazenbos, Wouter L W; Kajihara, Kimberly K; Vandlen, Richard; Morisaki, J Hiroshi; Lehar, Sophie M; Kwakkenbos, Mark J; Beaumont, Tim; Bakker, Arjen Q; Phung, Qui; Swem, Lee R; Ramakrishnan, Satish; Kim, Janice; Xu, Min; Shah, Ishita M; Diep, Binh An; Sai, Tao; Sebrell, Andrew; Khalfin, Yana; Oh, Angela; Koth, Chris; Lin, S Jack; Lee, Byoung-Chul; Strandh, Magnus; Koefoed, Klaus; Andersen, Peter S; Spits, Hergen; Brown, Eric J; Tan, Man-Wah; Mariathasan, Sanjeev

View on PubMed
The anatomy of successful computational biology software Nature Biotechnology, 2013, ISSN: 1087-0156

Altschul, Stephen; Demchak, Barry; Durbin, Richard; Gentleman, Robert; Krzywinski, Martin; Li, Heng; Nekrutenko, Anton; Robinson, James; Rasband, Wayne; Taylor, James; Trapnell, Cole

View on PubMed
ATLAS: Randomized, Double-Blind, Placebo-Controlled, Phase IIIB Trial Comparing Bevacizumab Therapy With or Without Erlotinib, After Completion of Chemotherapy, With Bevacizumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Johnson, Bruce E; Kabbinavar, Fairooz; Fehrenbacher, Louis; Hainsworth, John; Kasubhai, Saifuddin; Kressel, Bruce; Lin, Chin-Yu; Marsland, Thomas; Patel, Taral; Polikoff, Jonathan; Rubin, Mark; White, Leonard; Yang, James Chih-Hsin; Bowden, Chris; Miller, Vincent

View on PubMed
Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non-Small-Cell Lung Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Spigel, David R; Ervin, Thomas J; Ramlau, Rodryg A; Daniel, Davey B; Goldschmidt, Jerome H, Jr; Blumenschein, George R, Jr; Krzakowski, Maciej J; Robinet, Gilles; Godbert, Benoit; Barlesi, Fabrice; Govindan, Ramaswamy; Patel, Taral; Orlov, Sergey V; Wertheim, Michael S; Yu, Wei; Zha, Jiping; Yauch, Robert L; Patel, Premal H; Phan, See-Chun; Peterson, Amy C

View on PubMed
In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release Nature Medicine, 2013, ISSN: 1078-8956

Scheller, Richard

View on PubMed
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Lobsiger, Christian S.; Boillée, Severine; Pozniake, Christine; Khan, Amir M.; McAlonis-Downes, Melissa; Lewcock, Joseph W.; Cleveland, Don W.

View on PubMed
The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone PLoS ONE, 2013, ISSN:

André, Ingemar; Corn, Jacob

View on PubMed
Influence of tumour micro-environment heterogeneity on therapeutic response Nature, 2013, ISSN: 0028-0836

Junttila, Melissa; de Sauvage, Frederic

View on PubMed
Association of cyp2c9*2 with bosentan-induced liver injury Clinical Pharmacology and Therapeutics, 2013, ISSN: 0009-9236

Jason Halladay

View on PubMed
Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an IAP Antagonist Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Wong, Harvey; Gould, Stephen E; Budha, Nageshwar; Darbonne, Walter C; Kadel, Edward E, 3rd; La, Hank; Alicke, Bruno; Halladay, Jason S; Erickson, Rebecca; Portera, Chia; Tolcher, Anthony W; Infante, Jeffrey R; Mamounas, Michael; Flygare, John A; Hop, Cornelis Eca; Fairbrother, Wayne J

View on PubMed
Antibody Therapeutics in Cancer Science, 2013, ISSN: 0036-8075

Sliwkowski, Mark X; Mellman, Ira

View on PubMed
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells Nature Immunology, 2013, ISSN: 1529-2908

Rajasekaran, Kamalakannan; Kumar, Pawan; Schuldt, Kristina M.; Peterson, Erik J.; Vanhaesebroeck, Bart; Dixit, Vishva; Thakar, Monica S.; Malarkannan, Subramaniam

View on PubMed
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Misaghi, Shahram; Senger, Kate; Sai, Tao; Qu, Yan; Sun, Yonglian; Hamidzadeh, Kajal; Nguyen, Allen; Jin, Zhaoyu; Zhou, Meijuan; Yan, Donghong; Lin, Wei Yu; Lin, Zhonghua; Lorenzo, Maria N; Sebrell, Andrew; Ding, Jiabing; Xu, Min; Caplazi, Patrick; Austin, Cary D; Balazs, Mercedesz; Roose-Girma, Merone; Deforge, Laura; Warming, Søren; Lee, Wyne P; Dixit, Vishva M; Zarrin, Ali A

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2 PLoS ONE, 2013, ISSN: 1932-6203

Nelson, Christopher D; Sheng, Morgan

View on PubMed
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma Cancer Cell, 2013, ISSN: 1535-6108

Bhat, Krishna P.L.; Balasubramaniyan, Veerakumar; Vaillant, Brian; Ezhilarasan, Ravesanker; Hummelink, Karlijn; Hollingsworth, Faith; Wani, Khalida; Heathcock, Lindsey; James, Johanna D.; Goodman, Lindsey D.; Conroy, Siobhan; Long, Lihong; Lelic, Nina; Wang, Suzhen; Gumin, Joy; Raj, Divya; Kodama, Yoshinori; Raghunathan, Aditya; Olar, Adriana; Joshi, Kaushal; Pelloski, Christopher E.; Heimberger, Amy; Kim, SeHoon; Cahill, Daniel P.; Rao, Ganesh; DenDunnen, Wilfred F. A.; Boddeke, Hendrikus W.G.M.; Phillips, Heidi S.; Nakano, Ichiro; Lang, Frederick F.; Colman, Howard; Sulman, Erik P.; Aldape, Kenneth

View on PubMed
Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Welty, Nathan E.; Staley, Christopher; Ghilardi, Nico; Sadowsky, Michael J.; Igyarto, Botond Z.; Kaplan, Daniel H.

View on PubMed
Allosteric inhibition of BACE1 by an exosite-binding antibody Current Opinion in Structural Biology, 2013, ISSN: 1879-033X

Wang, Weiru; Liu, Yichin; Lazarus, Robert A

View on PubMed
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis Journal of Cell Biology, 2013, ISSN: 0021-9525

Huntwork-Rodriguez, Sarah; Wang, Bei; Watkins, Trent; Ghosh, Arundhati Sengupta; Pozniak, Christine D; Bustos, Daisy; Newton, Kim; Kirkpatrick, Donald S; Lewcock, Joseph W

View on PubMed
Fcy receptors enable anticancer action of proapoptotic and immune-modulatory antibodies Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Kim, Jeong; Ashkenazi, Avi

View on PubMed
Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results From a Randomized, Double-Blind, Phase III Study Arthritis & Rheumatism, 2013, ISSN:

Mysler, Eduardo F.; Spindler, Alberto J.; Guzman, Renato; Bijl, Marc; Jayne, David; Furie, Richard A.; Houssiau, Frederic A.; Drappa, Jorn; Close, David; Maciuca, Romeo; Rao, Kajal; Shahdad, Saba; Brunetta, Paul

View on PubMed
Regulation of deubiquitinase proteolytic activity Current Opinion in Structural Biology, 2013, ISSN: 0959-440X

Huang, Oscar W; Cochran, Andrea G

View on PubMed
Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Johnson, Leisa; Huseni, Mahrukh; Smyczek, Tanya; Lima, Anthony; Yeung, Stacey; Cheng, Jason; Molina, Rafael; Kan, David; De Mazier̀e, Ann; Klumperman, Judith; Kasman, Ian; Zhang, Yin; Dennis, Mark; Eastham-Anderson, Jeffrey; Jubb, Adrian; Hwang, Olivia; Desai, Rupal; Schmidt, Maike; Nannini, Michelle A.; Barck, Kai H.; Carano, Richard A. D.; Forrest, William F.; Song, Qinghua; Chen, Daniel S.; Naumovski, Louie; Singh, Mallika; Ye, Weilan; Hegde, Priti S.

View on PubMed
A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism Cancer Cell, 2013, ISSN: 1535-6108

Pribluda, Ariel; Elyada, Ela; Wiener, Zoltan; Hamza, Haya; Goldstein, RobertE.; Biton, Moshe; Burstain, Ido; Morgenstern, Yael; Brachya, Guy; Billauer, Hana; Biton, Sharon; Snir-Alkalay, Irit; Vucic, Domagoj; Schlereth, Katharina; Mernberger, Marco; Stiewe, Thorsten; Oren, Moshe; Alitalo, Kari; Pikarsky, Eli; Ben-Neriah, Yinon

View on PubMed
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers Nature, 2013, ISSN: 0028-0836

Hatzivassiliou, Georgia; Haling, Jacob R; Chen, Huifen; Song, Kyung; Price, Steve; Heald, Robert; Hewitt, Joanne F M; Zak, Mark; Peck, Ariana; Orr, Christine; Merchant, Mark; Hoeflich, Klaus P; Chan, Jocelyn; Luoh, Shiuh-Ming; Anderson, Daniel J; Ludlam, Mary J C; Wiesmann, Christian; Ultsch, Mark; Friedman, Lori S; Malek, Shiva; Belvin, Marcia

View on PubMed
Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors Journal of Clinical Pharmacology, 2013, ISSN: 0091-2700

Xin, Yan; Jin, Denise; Eppler, Stephen; Damico-Beyer, Lisa A; Joshi, Amita; Davis, John D; Kaur, Surinder; Nijem, Ihsan; Bothos, John; Peterson, Amy; Patel, Premal; Bai, Shuang

View on PubMed
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy Nature Medicine, 2013, ISSN:

Chung, Alicia; Xiumin Wu; Zhuang, Guanglei; Ngu, Hai; Kasman, Ian; Zhang, Jianhuan; Vernes, Jean-Michel; Jiang, Zhaoshi; Meng, Gloria; Peale, Franklin; Ouyang, Wenjun; Ferrara, Napoleone

View on PubMed
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens Nature Immunology, 2013, ISSN: 1529-2916

Satpathy, Ansuman; Briseno, Carlos; Lee, Jacob; Ng, Dennis; Manieri, Nicholas; KC, Wumesh; Wu, Xiaodi; Thomas, Stephanie; Lee, Wan-Ling; Turkoz, Mustafa; McDonald, Keely; Meredith, Matthew; Song, Christina; Guidos, Cynthia; Newberry, Rodney; Ouyang, Wenjun; Murphy, Theresa; Stappenbeck, Thaddeus; Gommerman, Jennifer; Nussenzweig, Michel; Colonna, Marco; Kopan, Raphael; Murphy, Kenneth

View on PubMed
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma Science Translational Medicine, 2013, ISSN: 1946-6234

Corcoran, Ryan B.; Rothenberg, Stephen Michael; Hata, Aaron N.; Faber, Anthony C.; Piris, Adriano; Nazarian, Rosalynn M.; Brown, Ronald D.; Godfrey, Jason T.; Winokur, Daniel; Walsh, John; Mino-Kenudson, Mari; Maheswaran, Shyamala; Settleman, Jeffrey; Wargo, Jennifer A.; Flaherty, Keith T.; Haber, Daniel A.; Engelman, Jeffrey A.

View on PubMed
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Lauffer, Benjamin E L; Mintzer, Robert; Fong, Rina; Mukund, Susmith; Tam, Christine; Zilberleyb, Inna; Flicke, Birgit; Ritscher, Allegra; Fedorowicz, Grazyna; Vallero, Roxanne; Ortwine, Daniel F; Gunzner, Janet; Modrusan, Zora; Neumann, Lars; Koth, Christopher M; Lupardus, Patrick J; Kaminker, Joshua S; Heise, Christopher E; Steiner, Pascal

View on PubMed
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death Nature Chemical Biology, 2013, ISSN: 1552-4450

Magnaghi, Paola; D'Alessio, Roberto; Valsasina, Barbara; Avanzi, Nilla; Rizzi, Simona; Asa, Daniela; Gasparri, Fabio; Cozzi, Liviana; Cucchi, Ulisse; Orrenius, Christian; Polucci, Paolo; Ballinari, Dario; Perrera, Claudia; Leone, Antonella; Cervi, Giovanni; Casale, Elena; Xiao, Yang; Wong, Chihunt; Anderson, Daniel J.; Galvani, Arturo; Donati, Daniele; O'Brien, Tom; Jackson, Peter K.; Isacchi, Antonella

View on PubMed
SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition PLoS ONE, 2013, ISSN: 1932-6203

Hanson, Jesse E; La, Hank; Plise, Emile; Chen, Yung-Hsiang; Ding, Xiao; Hanania, Taleen; Sabath, Emily V; Alexandrov, Vadim; Brunner, Dani; Leahy, Emer; Steiner, Pascal; Liu, Lichuan; Scearce-Levie, Kimberly; Zhou, Qiang

View on PubMed
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 Science, 2013, ISSN: 0036-8075

Kayagaki, Nobuhiko; Wong, Michael T; Stowe, Irma B; Ramani, Sree Ranjani; Gonzalez, Lino C; Akashi-Takamura, Sachiko; Miyake, Kensuke; Zhang, Juan; Lee, Wyne P; Muszynski, Artur; Forsberg, Lennart S; Carlson, Russell W; Dixit, Vishva M

View on PubMed
The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity Immunity, 2013, ISSN: 1097-4180

Wang, Yaya; Shaked, Iftach; Stanford, StephanieM.; Zhou, Wenbo; Curtsinger, JulieM.; Mikulski, Zbigniew; Shaheen, ZacharyR.; Cheng, Genhong; Sawatzke, Kristy; Campbell, AmandaM.; Auger, JenniferL.; Bilgic, Hatice; Shoyama, FernandaM.; Schmeling, DavidO.; Balfour, HenryH.; Hasegawa, Kiminori; Chan, Andrew C.; Corbett, JohnA.; Binstadt, BryceA.; Mescher, MatthewF.; Ley, Klaus; Bottini, Nunzio; Peterson, ErikJ.

View on PubMed
Label-Free High Throughput Assays to Screen and Characterize Novel Lactate Dehydrogenase Inhibitors Analytical Biochemistry, 2013, ISSN: 1096-0309

Vanderporten, Erica; Frick, Lauren; Turincio, Rebecca; Thana, Peter; Lamarr, William; Liu, Yichin

View on PubMed
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Merchant, Mark; Ma, Xiaolei; Maun, Henry R; Zheng, Zhong; Peng, Jing; Romero, Mally; Huang, Arthur; Yang, Nai-Ying; Nishimura, Merry; Greve, Joan; Santell, Lydia; Zhang, Yu-Wen; Su, Yanli; Kaufman, Dafna W; Billeci, Karen L; Mai, Elaine; Moffat, Barbara; Lim, Amy; Duenas, Eileen T; Phillips, Heidi S; Xiang, Hong; Young, Judy C; Vande Woude, George F; Dennis, Mark S; Reilly, Dorothea E; Schwall, Ralph H; Starovasnik, Melissa A; Lazarus, Robert A; Yansura, Daniel G

View on PubMed
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Spiess, Christoph; Bevers, Jack, 3rd; Jackman, Janet; Chiang, Nancy; Nakamura, Gerald; Dillon, Michael; Liu, Hongbin; Molina, Patricia; Elliott, J Michael; Shatz, Whitney; Scheer, Justin M; Giese, Glen; Persson, Josefine; Zhang, Yin; Dennis, Mark S; Giulianotti, James; Gupta, Prateek; Reilly, Dorothea; Palma, Enzo; Wang, Jianyong; Stefanich, Eric; Scheerens, Heleen; Fuh, Germaine; Wu, Lawren C

View on PubMed
An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza a antibodies Cell Host & Microbe, 2013, ISSN: 1931-3128

Nakamura, Gerald; Chai, Ning; Park, Summer; Chiang, Nancy; Lin, Zhonghua; Chiu, Henry; Fong, Rina; Yan, Donghong; Kim, Janice; Zhang, Juan; Lee, Wyne P; Estevez, Alberto; Coons, Mary; Xu, Min; Lupardus, Patrick; Balazs, Mercedesz; Swem, Lee R

View on PubMed
Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis PLoS ONE, 2013, ISSN: 1932-6203

Gogineni, Alvin; Caunt, Maresa; Crow, Ailey; Lee, Chingwei V; Fuh, Germaine; van Bruggen, Nicholas; Ye, Weilan; Weimer, Robby M

View on PubMed
Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling Blood, 2013, ISSN: 0006-4971

Wilson, Christopher; Parker, Leon; Hall, Christopher; Smyczek, Tanya; Mak, Judy; Crow, Ailey; Posthuma, George; De Mazière, Ann; Sagolla, Meredith; Chalouni, Cecile; Vitorino, Philip; Roose-Girma, Merone; Warming, Søren; Klumperman, Judith; Crosier, Philip; Ye, Weilan

View on PubMed
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Zheng, Xiaozhang; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Lin, Jian; Reynolds, Dominic J.; Sharma, Geeta; Smith, Chase C.; Wang, Zhongguo; Dragovich, Peter S.; Oh, Angela; Wang, Weiru; Zak, Mark; Gunzner-Toste, Janet; Zhao, Guiling; Yuen, Po-Wai; Bair, Kenneth W.

View on PubMed
B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response - art. no. e1003472 PLoS Pathogens, 2013, ISSN: 1553-7374

Kozakiewicz, Lee; Chen, Yong; Xu, Jiayong; Wang, Yanhua; Dunussi-Joannopoulos, Kyri; Ou, Qinglin; Flynn, Joanne L.; Porcelli, Steven A.; Jacobs, William R., Jr.; Chan, John

View on PubMed
A Rare Population of CD24+ITGB4+Notch hi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal Cancer Cell, 2013, ISSN: 1535-6108

Zheng, Yanyan; de la Cruz, Cecile C.; Sayles, Leanne C.; Alleyne-Chin, Chris; Vaka, Dedeepya; Knaak, Tim D.; Bigos, Marty; Xu, Yue; Hoang, Chuong D.; Shrager, Joseph B.; Fehling, HansJoerg; French, Dorothy; Forrest, William; Jiang, Zhaoshi; Carano, Richard A.D.; Barck, Kai H.; Jackson, Erica L.; Sweet-Cordero, E. Alejandro

View on PubMed
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies Nature Biotechnology, 2013, ISSN: 1087-0156

Christoph Spiess; Mark Merchant; Arthur Huang; Zhong Zheng; Nai-Ying Yang; Jing Peng; Diego Ellerman; Whitney Shatz; Dorothea Reilly; Daniel G Yansura; Justin M Scheer

View on PubMed
Decoding a Chain Letter for Degradation Structure, 2013, ISSN: 0969-2126

Cunningham, Christian N; Corn, Jacob E

View on PubMed
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development Proceedings of the National Academy of Sciences, 2013, ISSN:

Chen, Hao; Brady Ridgway, John; Sai, Tao; Lai, Joyce; Warming, Søren; Chen, Hanying; Roose-Girma, Merone; Zhang, Gu; Shou, Weinian; Yan, Minhong

View on PubMed
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes Nature, 2013, ISSN: 1476-4687

Kumar, Ritu; DiMenna, Lauren; Schrode, Nadine; Liu, Ting-Chun; Franck, Philipp; Munoz-Descalzo, Silvia; Hadjantonakis, Anna-Katerina; Zarrin, Ali A.; Chaudhuri, Jayanta; Elemento, Olivier; Evans, Todd

View on PubMed
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1 beta and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus Nature Immunology, 2013, ISSN: 1529-2908

Myles, Ian A.; Fontecilla, Natalia M.; Valdez, Patricia A.; Vithayathil, Paul J.; Naik, Shruti; Belkaid, Yasmine; Ouyang, Wenjun; Datta, Sandip K.

View on PubMed
Critical Review of Preclinical Approaches to Investigate Cytochrome P450-Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper Drug Metabolism and Disposition, 2013, ISSN:

Evers, Raymond; Dallas, Shannon; Dickmann, Leslie J.; Fahmi, Odette A.; Kenny, Jane R.; Kraynov, Eugenia; Theresa Nguyen; Patel, Aarti H.; Slatter, J. Greg; Zhang, Lei

View on PubMed
miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer PLoS ONE, 2013, ISSN:

Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan

View on PubMed
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Oh, Jaehak; Wu, Nan; Baravalle, Guenther; Cohn, Benjamin; Ma, Jessica; Lo, Bryan; Mellman, Ira; Ishido, Satoshi; Anderson, Mark; Shin, Jeoung-Sook

View on PubMed
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study The Lancet Oncology, 2013, ISSN: 1470-2045

Swain, Sandra M.; Kim, Sung-Bae; Cortés, Javier; Ro, Jungsil; Semiglazov, Vladimir; Campone, Mario; Ciruelos, Eva; Ferrero, Jean-Marc; Schneeweiss, Andreas; Knott, Adam; Clark, Emma; Ross, Graham; Benyunes, Mark C.; Baselga, José

View on PubMed
A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: Suppression of CYP3A by IL-6 Clinical Pharmacology and Therapeutics, 2013, ISSN: 0009-9236

MacHavaram, K.K.; Almond, L.M.; Rostami-Hodjegan, A.; Gardner, I.; Jamei, M.; Tay, S.; Wong, S.; Joshi, A.; Kenny, J.R.

View on PubMed
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Zindl, Carlene L.; Lai, Jen-Feng; Lee, Yun Kyung; Maynard, Craig L.; Harbour, Stacey N.; Ouyang, Wenjun; Chaplin, David D.; Weaver, Casey T.

View on PubMed
A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays PLoS ONE, 2013, ISSN: 1932-6203

Chan, Grace Ka Yan; Kleinheinz, Tracy L; Peterson, David; Moffat, John G

View on PubMed
Two-in-One antibodies with dual action Fabs Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931

Eigenbrot, Charles; Fuh, Germaine

View on PubMed
Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Liang, Jun; van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade; Chang, Christine; Delarosa, Donnie; Devoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Halladay, Jason; Johnson, Adam; Kohli, Pawan Bir; Lai, Yingjie; Liu, Yanzhou; Lyssikatos, Joseph; Mantik, Priscilla; Menghrajani, Kapil; Murray, Jeremy; Peng, Ivan; Sambrone, Amy; Shia, Steven; Shin, Young; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Wu, Lawren C; Xiao, Yisong; Yang, Wenqian; Young, Judy; Zhang, Birong; Zhu, Bing-Yan; Magnuson, Steven

View on PubMed
Discovery of 2-{3-2-(1-Isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzofimidazo1,2-d1,4oxazepin-9-yl-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Ndubaku, Chudi O; Heffron, Timothy P; Staben, Steven T; Baumgardner, Matthew; Blaquiere, Nicole; Bradley, Erin; Bull, Richard; Do, Steven; Dotson, Jennafer; Dudley, Danette; Edgar, Kyle A; Friedman, Lori S; Goldsmith, Richard; Heald, Robert A; Kolesnikov, Aleksandr; Lee, Leslie; Lewis, Cristina; Nannini, Michelle; Nonomiya, Jim; Pang, Jodie; Price, Steve; Prior, Wei Wei; Salphati, Laurent; Sideris, Steve; Wallin, Jeffery J; Wang, Lan; Wei, Binqing; Sampath, Deepak; Olivero, Alan G

View on PubMed
Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Zak, Mark; Hurley, Christopher A; Ward, Stuart I; Bergeron, Philippe; Barrett, Kathy; Balazs, Mercedesz; Blair, Wade S; Bull, Richard; Chakravarty, Paroma; Chang, Christine; Crackett, Peter; Deshmukh, Gauri; Devoss, Jason; Dragovich, Peter S; Eigenbrot, Charles; Ellwood, Charles; Gaines, Simon; Ghilardi, Nico; Gibbons, Paul; Gradl, Stefan; Gribling, Peter; Hamman, Chris; Harstad, Eric; Hewitt, Peter; Johnson, Adam; Johnson, Tony; Kenny, Jane R; Koehler, Michael F T; Bir Kohli, Pawan; Labadie, Sharada; Lee, Wyne P; Liao, Jiangpeng; Liimatta, Marya; Mendonca, Rohan; Narukulla, Raman; Pulk, Rebecca; Reeve, Austin; Savage, Scott; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; van Abbema, Anne; Aliagas, Ignacio; Avitabile-Woo, Barbara; Xiao, Yisong; Yang, Jing; Kulagowski, Janusz J

View on PubMed
Recapitulating human cancer in a mouse Nature Biotechnology, 2013, ISSN: 1087-0156

Chin, Lynda; De Sauvage, Frederic; Egeblad, Mikala; Olive, Kenneth P.; Tuveson, David; Weiss, William

View on PubMed
Evaluation of Tumor-Size Response Metrics to Predict Overall Survival in Western and Chinese Patients With First-Line Metastatic Colorectal Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Claret, Laurent; Gupta, Manish; Han, Kelong; Joshi, Amita; Sarapa, Nenad; He, Jing; Powell, Bob; Bruno, René

View on PubMed
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier Science Translational Medicine, 2013, ISSN: 1946-6234

Couch, Jessica A; Yu, Y Joy; Zhang, Yin; Tarrant, Jacqueline M; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Tong, Raymond K; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Gadkar, Kapil; Prabhu, Saileta; Ordonia, Benjamin A; Nguyen, Quyen; Lin, Yuwen; Lin, Zhonghua; Balazs, Mercedesz; Scearce-Levie, Kimberly; Ernst, James A; Dennis, Mark S; Watts, Ryan J

View on PubMed
EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS PLoS ONE, 2013, ISSN: 1932-6203

Le Pichon, Claire E; Dominguez, Sara L; Solanoy, Hilda; Ngu, Hai; Lewin-Koh, Nicholas; Chen, Mark; Eastham-Anderson, Jeffrey; Watts, Ryan; Scearce-Levie, Kimberly

View on PubMed
Optimization of drug-drug interaction study design: Comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Han, Bing; Mao, Jialin; Chien, Jenny Y.; Hall, Stephen D.

View on PubMed
Variability in P-Glycoprotein Inhibitory Potency (IC 50 ) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug- Drug Interaction Risk Assessment Decision Criterias Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Bentz, Joe; O'Connor, Michael P.; Bednarczyk, Dallas; Coleman, Joann; Lee, Caroline; Palm, Johan; Pak, Y. Anne; Perloff, Elke S.; Reyner, Eric; Balimane, Praveen; Brännström, Marie; Chu, Xiaoyan; Funk, Christoph; Guo, Ailan; Hanna, Imad; Herédi-Szabó, Krisztina; Hillgren, Kate; Li, Libin; Hollnack-Pusch, Evelyn; Jamei, Masoud; Lin, Xuena; Mason, Andrew K.; Neuhoff, Sibylle; Patel, Aarti; Podila, Lalitha; Plise, Emile; Rajaraman, Ganesh; Salphati, Laurent; Sands, Eric; Taub, Mitchell E.; Taur, Jan-Shiang; Weitz, Dietmar; Wortelboer, Heleen M.; Xia, Cindy Q.; Xiao, Guangqing; Yabut, Jocelyn; Yamagata, Tetsuo; Zhang, Lei; Ellens, Harma

View on PubMed
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactionss Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Ellens, Harma; Deng, Shibing; Coleman, Joann; Bentz, Joe; Taub, Mitchell E.; Ragueneau-Majlessi, Isabelle; Chung, Sophie P.; Herédi-Szabó, Krisztina; Neuhoff, Sibylle; Palm, Johan; Balimane, Praveen; Zhang, Lei; Jamei, Masoud; Hanna, Imad; O'connor, Michael; Bednarczyk, Dallas; Forsgard, Malin; Chu, Xiaoyan; Funk, Christoph; Guo, Ailan; Hillgren, Kathleen M.; Li, Libin; Pak, Anne Y.; Perloff, Elke S.; Rajaraman, Ganesh; Salphati, Laurent; Taur, Jan-Shiang; Weitz, Dietmar; Wortelboer, Heleen M.; Xia, Cindy Q.; Xiao, Guangqing; Yamagata, Tetsuo; Lee, Caroline A.

View on PubMed
Structure-guided design of a selective BCL-X-L inhibitor Nature Chemical Biology, 2013, ISSN: 1552-4450

Lessene, Guillaume; Czabotar, Peter E.; Sleebs, Brad E.; Zobel, Kerry; Lowes, Kym N.; Adams, Jerry M.; Baell, Jonathan B.; Colman, Peter M.; Deshayes, Kurt; Fairbrother, Wayne J.; Flygare, John A.; Gibbons, Paul; Kersten, Wilhelmus J. A.; Kulasegaram, Sanji; Moss, Rebecca M.; Parisot, John P.; Smith, Brian J.; Street, Ian P.; Yang, Hong; Huang, David C. S.; Watson, Keith G.

View on PubMed
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases Science Signaling, 2013, ISSN: 1945-0877

Zhuang, Guanglei; Yu, Kebing; Jiang, Zhaoshi; Chung, Alicia; Yao, Jenny; Ha, Connie; Toy, Karen; Soriano, Robert; Haley, Benjamin; Blackwood, Elizabeth; Sampath, Deepak; Bais, Carlos; Lill, Jennie R; Ferrara, Napoleone

View on PubMed
Sustainable practices in medicinal chemistry: current state and future directions Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Bryan, Marian C; Dillon, Barry; Hamann, Lawrence G; Hughes, Gregory J; Kopach, Michael E; Peterson, Emily A; Pourashraf, Mehrnaz; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen F

View on PubMed
Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing Drug Metabolism and Disposition, 2013, ISSN: 0090-9556

Liu, Xingrong; Wong, Harvey; Scearce-Levie, Kimberly; Watts, Ryan; Coraggio, Melis; Shin, Young; Peng, Kun; Wildsmith, Kristin; Atwal, Jasvinder; Mango, Jason; Schauer, Stephen; Regal, Kelly; Hunt, Kevin; Thomas, Allen; Siu, Mike; Lyssikatos, Joseph; Deshmukh, Gauri; Hop, Cornelis

View on PubMed
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation Journal of Experimental Medicine, 2013, ISSN: 0022-1007

Cohn, Lillian; Chatterjee, Bithi; Esselborn, Filipp; Smed-Sörensen, Anna; Nakamura, Norihiro; Chalouni, Cécile; Lee, Byoung-Chul; Vandlen, Richard; Keler, Tibor; Lauer, Peter; Brockstedt, Dirk; Mellman, Ira; Delamarre, Lélia

View on PubMed
Bispecific antibodies for delivery into the brain Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931

Watts, Ryan J; Dennis, Mark S

View on PubMed
Blockade of individual notch ligands and receptors controls graft-versus-host disease Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Tran, Ivy T.; Sandy, Ashley R.; Carulli, Alexis J.; Ebens, Christen; Chung, Jooho; Shan, Gloria T.; Radojcic, Vedran; Friedman, Ann; Gridley, Thomas; Shelton, Amy; Reddy, Pavan; Samuelson, Linda C.; Yan, Minhong; Siebel, Christian W.; Maillard, Ivan

View on PubMed
Blockade of individual Notch ligands and receptors to control graft-versus-host disease Journal of Clinical Investigation, 2013, ISSN:

Ivy T Tran; Ashley R Sandy; Alexis J Carulli; Christen Ebens; Jooho Chung; Gloria T Shan; Vedran Radojcic; Ann Friedman; Thomas Gridley; Amy Shelton; Pavan Reddy; Linda C Samuelson; Minhong Yan; Christian W Siebel; Ivan Maillard

View on PubMed
OTUB1 modulates c-IAP1 stability to regulate signalling pathways EMBO Journal, 2013, ISSN: 0261-4189

Goncharov, Tatiana; Niessen, Kyle; de Almagro, Maria Cristina; Izrael-Tomasevic, Anita; Fedorova, Anna V; Varfolomeev, Eugene; Arnott, David; Deshayes, Kurt; Kirkpatrick, Donald S; Vucic, Domagoj

View on PubMed
Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Hunt, Kevin W.; Cook, Adam W.; Watts, Ryan J.; Clark, Christopher T.; Vigers, Guy; Smith, Darin; Metcalf, Andrew T.; Gunawardana, Indrani W.; Burkard, Michael; Cox, April A.; Geck Do, Mary K.; Dutcher, Darrin; Thomas, Allen A.; Rana, Sumeet; Kallan, Nicholas C.; Delisle, Robert K.; Rizzi, James P.; Regal, Kelly; Sammond, Douglas; Groneberg, Robert; Siu, Michael; Purkey, Hans; Lyssikatos, Joseph P.; Marlow, Allison; Liu, Xingrong; Tang, Tony P.

View on PubMed
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Phan, Vernon; Wu, Xiumin; Cheng, Jason; Sheng, Rebecca; Chung, Alicia; Zhuang, Guanglei; Tran, Christopher; Song, Qinghua; Kowanetz, Marcin; Sambrone, Amy; Tan, Martha; Meng, Gloria; Jackson, Erica; Peale, Franklin; Junttila, Melissa; Ferrara, Napoleone

View on PubMed
Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung PLOS GENETICS, 2013, ISSN: 1553-7404

Calvi, Carla; Podowski, Megan; Lopez-Mercado, Armando; Metzger, Shana; Misono, Kaori; Malinina, Alla; Dikeman, Dustin; Poonyagariyon, Hataya; Ynalvez, Leslie; Derakhshandeh, Roshanak; Le, Anne; Merchant, Mark; Schwall, Ralph; Neptune, Enid R.

View on PubMed
Rer1p maintains ciliary length and signaling by regulating gamma-secretase activity and Foxj1a levels Journal of Cell Biology, 2013, ISSN: 0021-9525

Jurisch-Yaksi, Nathalie; Rose, Applonia J.; Lu, Huiqi; Raemaekers, Tim; Munck, Sebastian; Baatsen, Pieter; Baert, Veerle; Vermeire, Wendy; Scales, Suzie J.; Verleyen, Daphne; Vandepoel, Roel; Tylzanowski, Przemko; Yaksi, Emre; de Ravel, Thomy; Yost, H. Joseph; Froyen, Guy; Arrington, Cammon B.; Annaert, Wim

View on PubMed
Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR) Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

Estrada, Anthony A; Shore, Daniel G; Blackwood, Elizabeth; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Dipasquale, Antonio G; Epler, Jennifer A; Friedman, Lori S; Koehler, Michael F T; Liu, Lichuan; Malek, Shiva; Nonomiya, Jim; Ortwine, Daniel F; Pei, Zhonghua; Sideris, Steve; St-Jean, Frederic; Trinh, Lan; Truong, Tom; Lyssikatos, Joseph P

View on PubMed
Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study Journal of Clinical Pharmacology, 2013, ISSN: 0091-2700

George, Samuel; Rodriguez, Ignacio; Ipe, David; Sager, Philip T.; Gussak, Ihor; Vajdic, Branislav

View on PubMed
PAR-1 contributes to the innate immune response during viral infection Journal of Clinical Investigation, 2013, ISSN: 0021-9738

Antoniak, Silvio; Owens III, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, Jo Ann; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

View on PubMed
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma Cell, 2013, ISSN: 0092-8674

Snuderl, Matija; Batista, Ana; Kirkpatrick, Nathaniel D.; De Almodovar, Carmen Ruiz; Riedemann, Lars; Walsh, Elisa C.; Anolik, Rachel; Huang, Yuhui; Martin, John D.; Kamoun, Walid; Knevels, Ellen; Schmidt, Thomas; Farrar, Christian T.; Vakoc, Benjamin J.; Mohan, Nishant; Chung, Euiheon; Roberge, Sylvie; Peterson, Teresa; Bais, Carlos; Zhelyazkova, Boryana H.; Yip, Stephen; Hasselblatt, Martin; Rossig, Claudia; Niemeyer, Elisabeth; Ferrara, Napoleone; Klagsbrun, Michael; Duda, Dan G.; Fukumura, Dai; Xu, Lei; Carmeliet, Peter; Jain, Rakesh K.

View on PubMed
Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type i serine proteases Fromtransmembrane anchors Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Raman, Kavita; Trivedi, Neil N.; Raymond, Wilfred W.; Ganesan, Rajkumar; Kirchhofer, Daniel; Verghese, George M.; Craik, Charles S.; Schneider, Eric L.; Nimishakavi, Shilpa; Caughey, George H.

View on PubMed
Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia PLoS ONE, 2013, ISSN: 1932-6203

Wu, Ai-Luen; Feng, Bo; Chen, Mark Z; Kolumam, Ganesh; Zavala-Solorio, Jose; Wyatt, Shelby K; Gandham, Vineela D; Carano, Richard A D; Sonoda, Junichiro

View on PubMed
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury Proceedings of the National Academy of Sciences, 2013, ISSN: 0027-8424

Watkins, Trent A; Wang, Bei; Huntwork-Rodriguez, Sarah; Yang, Jing; Jiang, Zhiyu; Eastham-Anderson, Jeffrey; Modrusan, Zora; Kaminker, Joshua S; Tessier-Lavigne, Marc; Lewcock, Joseph W

View on PubMed
Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production Journal of Biological Chemistry, 2013, ISSN: 0021-9258

Kearney, Conor J.; Sheridan, Clare; Cullen, Sean P.; Tynan, Graham A.; Logue, Susan E.; Afonina, Inna S.; Vucic, Domagoj; Lavelle, Ed C.; Martin, Seamus J.

View on PubMed
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery EMBO Reports, 2013, ISSN: 1469-221X

Lee, Dong Yun; Arnott, David; Brown, Eric J.

View on PubMed
Personalizing medicine for autoimmune and inflammatory diseases Nature Immunology, 2013, ISSN: 1529-2908

Chan, Andrew C.; Behrens, Timothy W.

View on PubMed
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance Blood, 2013, ISSN: 0006-4971

Lee, Sung-Uk; Maeda, Manami; Ishikawa, Yuichi; Li, Sierra Min; Wilson, Anne; Jubb, Adrian M.; Sakurai, Nagisa; Weng, Lihong; Fiorini, Emma; Radtke, Freddy; Yan, Minhong; MacDonald, H. Robson; Chen, Ching-Cheng; Maeda, Takahiro

View on PubMed
Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer Science Translational Medicine, 2013, ISSN: 1946-6234

Hegde, Ganapati V; de la Cruz, Cecile C; Chiu, Cecilia; Alag, Navneet; Schaefer, Gabriele; Crocker, Lisa; Ross, Sarajane; Goldenberg, David; Merchant, Mark; Tien, Janet; Shao, Lily; Roth, Leslie; Tsai, Siao-Ping; Stawicki, Scott; Jin, Zhaoyu; Wyatt, Shelby K; Carano, Richard A D; Zheng, Yanyan; Sweet-Cordero, E Alejandro; Wu, Yan; Jackson, Erica L

View on PubMed
Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice PLoS ONE, 2013, ISSN:

Sarikonda, Ghanashyam; Sachithanantham, Sowbarnika; Manenkova, Yulia; Kupfer, Tinalyn; Posgai, Amanda; Wasserfall, Clive; Bernstein, Philip; Straub, Laura; Pagni, Philippe P.; Schneider, Darius; Calvo, Teresa Rodriguez; Coulombe, Marilyne; Herold, Kevan; Gill, Ronald G.; Atkinson, Mark; Nepom, Gerald; Ehlers, Mario; Staeva, Teodora; Garren, Hideki; Steinman, Lawrence; Chan, Andrew C.; von Herrath, Matthias

View on PubMed
Phase II Randomized Study of Trastuzumab Emtansine Versus Trastuzumab Plus Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Postive Metastatic Breast Cancer Journal of Clinical Oncology, 2013, ISSN: 0732-183X

Hurvitz, Sara A; Dirix, Luc; Kocsis, Judit; Bianchi, Giulia V; Lu, Janice; Vinholes, Jeferson; Guardino, Ellie; Song, Chunyan; Tong, Barbara; Ng, Vivian; Chu, Yu-Waye; Perez, Edith A

View on PubMed
Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling Science, 2013, ISSN: 0036-8075

Huang, Xiaodong; McGann, James C; Liu, Bob Y; Hannoush, Rami N; Lill, Jennie R; Pham, Victoria; Newton, Kim; Kakunda, Michael; Liu, Jinfeng; Yu, Christine; Hymowitz, Sarah G; Hongo, Jo-Anne; Wynshaw-Boris, Anthony; Polakis, Paul; Harland, Richard M; Dixit, Vishva M

View on PubMed
The burden of faulty proofreading in colon cancer Nature Genetics, 2013, ISSN: 1061-4036

Seshagiri, Somasekar

View on PubMed
Neuroscience: Strength in numbers Nature, 2013, ISSN: 0028-0836

Sheng, Morgan; Malinow, Roberto; Huganir, Richard

View on PubMed
The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling Cell, 2013, ISSN: 0092-8674

Mukhopadhyay, Saikat; Wen, Xiaohui; Ratti, Navneet; Loktev, Alexander; Rangell, Linda; Scales, Suzie J; Jackson, Peter K

View on PubMed
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial The Lancet Oncology, 2013, ISSN: 1470-2045

Bennouna, Jaafar; Sastre, Javier; Arnold, Dirk; Österlund, Pia; Greil, Richard; Van Cutsem, Eric; von Moos, Roger; Viéitez, Jose Maria; Bouché, Olivier; Borg, Christophe; Steffens, Claus-Christoph; Alonso-Orduña, Vicente; Schlichting, Christoph; Reyes-Rivera, Irmarie; Bendahmane, Belguendouz; André, Thierry; Kubicka, Stefan

View on PubMed
Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models Cancer Cell, 2013, ISSN: 1535-6108

Corcoran, Ryan B.; Cheng, Katherine A.; Hata, Aaron N.; Faber, Anthony C.; Ebi, Hiromichi; Coffee, Erin M.; Greninger, Patricia; Brown, Ronald D.; Godfrey, Jason T.; Cohoon, Travis J.; Song, Youngchul; Lifshits, Eugene; Hung, Kenneth E.; Shioda, Toshi; Dias-Santagata, Dora; Singh, Anurag; Settleman, Jeffrey; Benes, Cyril H.; Mino-Kenudson, Mari; Wong, Kwok-Kin; Engelman, Jeffrey A.

View on PubMed
The Akt DUBbed InAktive Science Signaling, 2013, ISSN:

Lin, Kui

View on PubMed
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Nature Medicine, 2013, ISSN: 1078-8956

Souers, Andrew J.; Leverson, Joel D.; Boghaert, Erwin R.; Ackler, Scott L.; Catron, Nathaniel D.; Chen, Jun; Dayton, Brian D.; Ding, Hong; Enschede, Sari H.; Fairbrother, Wayne J.; Huang, David C. S.; Hymowitz, Sarah G.; Jin, Sha; Khaw, Seong Lin; Kovar, Peter J.; Lam, Lloyd T.; Lee, Jackie; Maecker, Heather L.; Marsh, Kennan C.; Mason, Kylie D.; Mitten, Michael J.; Nimmer, Paul M.; Oleksijew, Anatol; Park, Chang H.; Park, Cheol-Min; Phillips, Darren C.; Roberts, Andrew W.; Sampath, Deepak; Seymour, John F.; Smith, Morey L.; Sullivan, Gerard M.; Tahir, Stephen K.; Tse, Chris; Wendt, Michael D.; Xiao, Yu; Xue, John C.; Zhang, Haichao; Humerickhouse, Rod A.; Rosenberg, Saul H.; Elmore, Steven W.

View on PubMed
Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody-Drug Conjugates Analytical Chemistry, 2013, ISSN: 0003-2700

Chen, Jia; Yin, Sheng; Wu, Yongjian; Ouyang, Jun

View on PubMed
A tumor-specific stem cell Nature Genetics, 2012, ISSN: 1061-4036

Metcalfe, Ciara; de Sauvage, Frederic J

View on PubMed
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways Journal of Cell Biology, 2012, ISSN: 0021-9525

Lo, Bryan; Strasser, Geraldine; Sagolla, Meredith; Austin, Cary D.; Junttila, Melissa; Mellman, Ira

View on PubMed
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators PLoS ONE, 2012, ISSN: 1932-6203

Scheer, Justin M; Sandoval, Wendy; Elliott, J Michael; Shao, Lily; Luis, Elizabeth; Lewin-Koh, Sock-Cheng; Schaefer, Gabriele; Vandlen, Richard

View on PubMed
Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genetics, 2012, ISSN:

Bendesky, Andres; Pitts, Jason; Rockman, Matthew; Chen, William; Tan, Man-Wah; Kruglyak, Leonid; Bargmann, Cornelia

View on PubMed
Application of a new wall-less plate technology to complex multi-step cell-based investigations using suspension cells Blood, 2012, ISSN: 0006-4971

Quiñones, Gabriel A; Moore, Travis I; Nicholes, Katrina; Lee, Hyunjae; Kim, Sudong; Sun, Laura; Jeon, Noo Li; Stephan, Jean-Philippe

View on PubMed
Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel PLoS ONE, 2012, ISSN:

Patel, Rajesh; Tsan, Alison; Tam, Rachel; Desai, Rupal; Schoenbrunner, Nancy; Myers, Thomas W.; Bauer, Keith; Smith, Edward; Raja, Rajiv

View on PubMed
Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Polucci, Paolo; Magnaghi, Paola; Angiolini, Mauro; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Bertrand, Jay; Casale, Elena; Cauteruccio, Silvia; Cirla, Alessandra; Cozzi, Liviana; Galvani, Arturo; Jackson, Peter K.; Liu, Yichin; Magnuson, Steven; Malgesini, Beatrice; Nuvoloni, Stefano; Orrenius, Christian; Sirtori, Federico Riccardi; Riceputi, Laura; Rizzi, Simona; Trucchi, Beatrice; O'Brien, Tom; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto

View on PubMed
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria Immunity, 2012, ISSN:

Basu, Rajatava; O’Quinn, Darrell; Silberger, Daniel; Schoeb, Trenton; Fouser, Lynette; Ouyang, Wenjun; Hatton, Robin; Weaver, Casey

View on PubMed
Cyanide Anion as a Leaving Group in Nucleophilic Aromatic Substitution: Synthesis of Quaternary Centers at Azine Heterocycles Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Thompson, Alexander D; Huestis, Malcolm P

View on PubMed
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations Science Translational Medicine, 2012, ISSN: 1946-6234

Sheng, Zejuan; Zhang, Shuo; Bustos, Daisy; Kleinheinz, Tracy; Le Pichon, Claire E; Dominguez, Sara L; Solanoy, Hilda O; Drummond, Jason; Zhang, Xiaolin; Ding, Xiao; Cai, Fang; Song, Qinghua; Li, Xianting; Yue, Zhenyu; van der Brug, Marcel P; Burdick, Daniel J; Gunzner-Toste, Janet; Chen, Huifen; Liu, Xingrong; Estrada, Anthony A; Sweeney, Zachary K; Scearce-Levie, Kimberly; Moffat, John G; Kirkpatrick, Donald S; Zhu, Haitao

View on PubMed
The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-like Superfamily Biochemistry, 2012, ISSN: 1520-4995

Parsiegla, Goetz; Noguere, Christophe; Santell, Lydia; Lazarus, Robert A.; Bourne, Yves

View on PubMed
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 PLoS ONE, 2012, ISSN: 1932-6203

Heise, Christopher E; Murray, Jeremy; Augustyn, Katherine E; Bravo, Brandon; Chugha, Preeti; Cohen, Frederick; Giannetti, Anthony M; Gibbons, Paul; Hannoush, Rami N; Hearn, Brian R; Jaishankar, Priyadarshini; Ly, Cuong Q; Shah, Kinjalkumar; Stanger, Karen; Steffek, Micah; Tang, Yinyan; Zhao, Xianrui; Lewcock, Joseph W; Renslo, Adam R; Flygare, John; Arkin, Michelle R

View on PubMed
Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-amino-1,2,3-thiadiazole Drug Metabolism and Disposition, 2012, ISSN: 0090-9556

Yue, Qin; Mulder, Teresa; Rudewicz, Patrick J; Solon, Eric; Budha, Nageshwar; Ware, Joseph A; Lyssikatos, Joseph; Hop, Cornelis E C A; Wong, Harvey; Khojasteh, S Cyrus

View on PubMed
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 Nature Immunology, 2012, ISSN: 1529-2908

Wang, Chenhui; Wu, Ling; Bulek, Katarzyna; Martin, Bradley N.; Zepp, Jarod A.; Kang, Zizhen; Liu, Caini; Herjan, Tomasz; Misra, Saurav; Carman, Julie A.; Gao, Ji; Dongre, Ashok; Han, Shujie; Bunting, Kevin D.; Ko, Jennifer S.; Xiao, Hui; Kuchroo, Vijay K.; Ouyang, Wenjun; Li, Xiaoxia

View on PubMed
Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase Journal of Biological Chemistry, 2012, ISSN: 0021-9258

King, Gordon J.; Stöckli, Jacqueline; Hu, Shu-Hong; Winnen, Brit; Duprez, Wilko G. A.; Meoli, Christopher C.; Junutula, Jagath R.; Jarrott, Russell J.; James, David E.; Whitten, Andrew E.; Martin, Jennifer L.

View on PubMed
Potent, selective, and orally bioavailable inhibitors of the Mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Koehler, Michael F T; Bergeron, Philippe; Blackwood, Elizabeth; Bowman, Krista K; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Epler, Jennifer; Lau, Kevin; Lee, Leslie; Liu, Lichuan; Ly, Cuong; Malek, Shiva; Nonomiya, Jim; Oeh, Jason; Ortwine, Daniel F; Sampath, Deepak; Sideris, Steve; Trinh, Lan; Truong, Tom; Wu, Jiansheng; Pei, Zhonghua; Lyssikatos, Joseph P

View on PubMed
Identification of mutant KRas-dependent phenotypes using a panel of isogenic cell lines Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Vartanian, Steffan; Bentley, Carolyn; Brauer, Matthew J; Li, Li; Shirasawa, Senji; Sasazuki, Takehiko; Kim, Jun-Sik; Haverty, Pete; Stawiski, Eric; Modrusan, Zora; Waldman, Todd; Stokoe, David

View on PubMed
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7 Nature Chemical Biology, 2012, ISSN: 1552-4450

Zhang, Yingnan; Zhou, Lijuan; Rouge, Lionel; Phillips, Aaron H; Lam, Cynthia; Liu, Peter; Sandoval, Wendy; Helgason, Elizabeth; Murray, Jeremy M; Wertz, Ingrid E; Corn, Jacob E

View on PubMed
Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Li, Jing; Zhi, Jianguo; Wenger, Michael; Valente, Nancy; Dmoszynska, Anna; Robak, Tadeusz; Mangat, Ranvir; Joshi, Amita; Visich, Jennifer

View on PubMed
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletss Journal of Pharmacology and Experimental Therapeutics, 2012, ISSN: 0022-3565

Li, Xiaoyan Nina; Herrington, James; Petrov, Aleksandr; Ge, Lan; Eiermann, George; Xiong, Yusheng; Jensen, Mette V.; Hohmeier, Hans E.; Newgard, Christopher B.; Garcia, Maria L.; Wagner, Michael; Zhang, Bei B.; Thornberry, Nancy A.; Howard, Andrew D.; Kaczorowski, Gregory J.; Zhou, Yun-Ping

View on PubMed
Pharmacokinetics and pharmacodynamics of anti-BR3 monoclonal antibody in mice Pharmaceutical Research, 2012, ISSN: 0724-8741

Marathe, Anshu; Iyer, Suhasini; Qiu, Zhihua Julia; Visich, Jennifer; Mager, Donald E.

View on PubMed
TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias Cell, 2012, ISSN: 0092-8674

Jackson, Peter;

View on PubMed
Improving risk assessment Science Translational Medicine, 2012, ISSN: 1946-6234

Dambach, Donna M; Uppal, Hirdesh

View on PubMed
Furin-cleaved PCSK9 is active and modulates LDL receptor and serum cholesterol levels Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Lipari, Michael T; Li, Wei; Moran, Paul; Kong-Beltran, Monica; Sai, Tao; Lai, Joyce; Lin, S Jack; Kolumam, Ganesh; Zavala-Solorio, Jose; Izrael-Tomasevic, Anita; Arnott, David; Wang, Jianyong; Peterson, Andrew S; Kirchhofer, Daniel

View on PubMed
TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer Molecular Cell, 2012, ISSN:

Gonzalvez, Francois; Lawrence, David; Yang, Becky; Yee, Sharon; Pitti, Robert; Marsters, Scot; Pham, Victoria C; Stephan, Jean-Philippe; Lill, Jennie; Ashkenazi, Avi

View on PubMed
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci American Journal of Human Genetics, 2012, ISSN: 0002-9297

Asselbergs, Folkert W.; Guo, Yiran; Van Iperen, Erik P.A.; Sivapalaratnam, Suthesh; Tragante, Vinicius; Lanktree, Matthew B.; Lange, Leslie A.; Almoguera, Berta; Appelman, Yolande E.; Barnard, John; Baumert, Jens; Beitelshees, Amber L.; Bhangale, Tushar R.; Chen, Yii-Der Ida; Gaunt, Tom R.; Gong, Yan; Hopewell, Jemma C.; Johnson, Toby; Kleber, Marcus E.; Langaee, Taimour Y.; Li, Mingyao; Li, Yun R.; Liu, Kiang; McDonough, Caitrin W.; Meijs, Matthijs F.L.; Middelberg, Rita P.S.; Musunuru, Kiran; Nelson, Christopher P.; O'Connell, Jeffery R.; Padmanabhan, Sandosh; Pankow, James S.; Pankratz, Nathan; Rafelt, Suzanne; Rajagopalan, Ramakrishnan; Romaine, Simon P.R.; Schork, Nicholas J.; Shaffer, Jonathan; Shen, Haiqing; Smith, Erin N.; Tischfield, Sam E.; Van Der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Verweij, Niek; Volcik, Kelly A.; Zhang, Li; Bailey, Kent R.; Bailey, Kristian M.; Bauer, Florianne; Boer, Jolanda M.A.; Braund, Peter S.; Burt, Amber; Burton, Paul R.; Buxbaum, Sarah

View on PubMed
Characterization of rat liver proteins adducted by reactive metabolites of menthofuran Chemical Research in Toxicology, 2012, ISSN: 0893-228X

Khojasteh, S. Cyrus; Hartley, Dylan P.; Ford, Kevin A.; Uppal, Hirdesh; Oishi, Shimako; Nelson, Sidney D.

View on PubMed
Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity PloS ONE, 2012, ISSN: 1932-6203

Hegde, Ganapati V; de la Cruz, Cecile; Eastham-Anderson, Jeffrey; Zheng, Yanyan; Sweet-Cordero, E Alejandro; Jackson, Erica L

View on PubMed
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine Nature, 2012, ISSN:

Huber, Samuel; Gagliani, Nicola; Zenewicz, Lauren; Huber Francis; Bosurgi, Lidia; Hu, Bo; Hedl Matija; Zhang, Wei; O’Connor, William; Murphy, Andrew; Valenzuela, David; Yancopoulos, George; Booth, Carmen; Cho, Judy; Ouyang, Wenjun; Abraham, Clara; Flavell, Richard

View on PubMed
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function Cell, 2012, ISSN: 0092-8674

Jin, Jing; Sison, Karen; Li, Chengjin; Tian, Ruijun; Wnuk, Monika; Sung, Hoon-Ki; Jeansson, Marie; Zhang, Cunjie; Tucholska, Monika; Jones, Nina; Kerjaschki, Dontscho; Shibuya, Masabumi; Fantus, I. George; Nagy, Andras; Gerber, Hans-Peter; Ferrara, Napoleone; Pawson, Tony; Quaggin, Susan E.

View on PubMed
Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P.

View on PubMed
Evaluation of semi-homogeneous assay formats for dual-specificity antibodies Journal of Immunological Methods, 2012, ISSN: 1872-7905

Jiang, Guoying; Lee, Chung W; Wong, Pin Yee; Gazzano-Santoro, Hélène

View on PubMed
Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial Nature Reviews, 2012, ISSN: 1474-1733

Horvath, Christopher; Andrews, Laura; Baumann, Andreas; Black, Lauren; Blanset, Diann; Cavagnaro, Joy; Hastings, Kenneth; Hutto, David; MacLachlan, Timothy; Milton, Mark; Reynolds, Theresa; Roberts, Stan; Rogge, Mark; Sims, Jennifer; Treacy, George; Warner, Garvin; Green, James;

View on PubMed
Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer New England Journal of Medicine, 2012, ISSN: 0028-4793

Verma, Sunil; Miles, David; Gianni, Luca; Krop, Ian E; Welslau, Manfred; Baselga, José; Pegram, Mark; Oh, Do-Youn; Diéras, Véronique; Guardino, Ellie; Fang, Liang; Lu, Michael W; Olsen, Steven; Blackwell, Kim

View on PubMed
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification Cell, 2012, ISSN: 0092-8674

Samstein, Robert M.; Arvey, Aaron; Josefowicz, Steven Z.; Peng, Xiao; Reynolds, Alex; Sandstrom, Richard; Neph, Shane; Sabo, Peter; Kim, Jeong M.; Liao, Will; Li, Ming O.; Leslie, Christina; Stamatoyannopoulos, John A.; Rudensky, Alexander Y.

View on PubMed
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Parikh, Chaitali; Janakiraman, Vasantharajan; Wu, Wen-I; Foo, Catherine K; Kljavin, Noelyn M; Chaudhuri, Subhra; Stawiski, Eric; Lee, Brian; Lin, Jie; Li, Hong; Lorenzo, Maria N; Yuan, Wenlin; Guillory, Joseph; Jackson, Marlena; Rondon, Jesus; Franke, Yvonne; Bowman, Krista K; Sagolla, Meredith; Stinson, Jeremy; Wu, Thomas D; Wu, Jiansheng; Stokoe, David; Stern, Howard M; Brandhuber, Barbara J; Lin, Kui; Skelton, Nicholas J; Seshagiri, Somasekar

View on PubMed
Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans Pharmaceutical Research, 2012, ISSN: 0724-8741

Xin, Yan; Bai, Shuang; Damico-Beyer, Lisa A.; Jin, Denise; Liang, Wei-Ching; Wu, Yan; Theil, Frank-Peter; Joshi, Amita; Lu, Yanmei; Lowe, John; Maia, Mauricio; Brachmann, Rainer K.; Xiang, Hong

View on PubMed
Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT Blood, 2012, ISSN: 0006-4971

Mali, Raghuveer Singh; Ma, Peilin; Zeng, Li-Fan; Martin, Holly; Ramdas, Baskar; He, Yantao; Sims, Emily; Nabinger, Sarah; Ghosh, Joydeep; Sharma, Namit; Munugalavadla, Veerendra; Chatterjee, Anindya; Li, Shuo; Sandusky, George; Craig, Andrew W.; Bunting, Kevin D.; Feng, Gen-Sheng; Chan, Rebecca J.; Zhang, Zhong-Yin; Kapur, Reuben

View on PubMed
Development of an ELISA based bridging assay as a surrogate measure of ADCC Journal of Immunological Methods, 2012, ISSN: 0022-1759

Miller, Aaron S; Tejada, Max L; Gazzano-Santoro, Hélène

View on PubMed
Genomic landscape of liver cancer Nature Genetics, 2012, ISSN: 1061-4036

Zhang, Zemin;

View on PubMed
Pharmacokinetic Considerations for Antibody Drug Conjugates Pharmaceutical Research, 2012, ISSN: 0724-8741

Lin, Kedan; Tibbitts, Jay

View on PubMed
Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial The Lancet Oncology, 2012, ISSN: 1470-2045

Ismael, Gustavo; Hegg, Roberto; Muehlbauer, Susanne; Heinzmann, Dominik; Lum, Bert; Kim, Sung-Bae; Pienkowski, Tadeusz; Lichinitser, Mikhail; Semiglazov, Vladimir; Melichar, Bohuslav; Jackisch, Christian

View on PubMed
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human Drug Metabolism and Disposition, 2012, ISSN: 0090-9556

Salphati, Laurent; Pang, Jodie; Plise, Emile G.; Lee, Leslie B.; Olivero, Alan G.; Prior, Wei Wei; Sampath, Deepak; Wong, Susan; Zhang, Xiaolin

View on PubMed
Childhood disorders of the synapse: Challenges and opportunities Science Translational Medicine, 2012, ISSN: 1946-6234

Hughes, Virginia; Sheng, Morgan; Zoghbi, Huda

View on PubMed
Compensatory dendritic cell development mediated by BATF-IRF interactions Nature, 2012, ISSN: 0028-0836

Tussiwand, Roxane; Lee, Wan-Ling; Murphy, Theresa L.; Mashayekhi, Mona; Kc, Wumesh; Albring, Jörn C.; Satpathy, Ansuman T.; Rotondo, Jeffrey A.; Edelson, Brian T.; Kretzer, Nicole M.; Wu, Xiaodi; Weiss, Leslie A.; Glasmacher, Elke; Li, Peng; Liao, Wei; Behnke, Michael; Lam, Samuel S. K.; Aurthur, Cora T.; Leonard, Warren J.; Singh, Harinder; Stallings, Christina L.; David Sibley, L.; Schreiber, Robert D.; Murphy, Kenneth M.

View on PubMed
Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging PLoS ONE, 2012, ISSN: 1932-6203

Kamath, Amrita V; Williams, Simon P; Bullens, Sherry; Cowan, Kyra J; Stenberg, Yvonne; Cherry, Simon R; Rendig, Stephen; Kukis, David L; Griesemer, Chris; Damico-Beyer, Lisa A; Bunting, Stuart

View on PubMed
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Estrada, Anthony A.; Liu, Xingrong; Baker-Glenn, Charles; Beresford, Alan; Burdick, Daniel J.; Chambers, Mark; Chan, Bryan K.; Chen, Huifen; Ding, Xiao; Dipasquale, Antonio G.; Dominguez, Sara L.; Dotson, Jennafer; Drummond, Jason; Flagella, Michael; Flynn, Sean; Fuji, Reina; Gill, Andrew; Gunzner-Toste, Janet; Harris, Seth F.; Heffron, Timothy P.; Kleinheinz, Tracy; Lee, Donna W.; Le Pichon, Claire E.; Lyssikatos, Joseph P.; Medhurst, Andrew D.; Moffat, John G.; Mukund, Susmith; Nash, Kevin; Scearce-Levie, Kimberly; Sheng, Zejuan; Shore, Daniel G.; Tran, Thuy; Trivedi, Naimisha; Wang, Shumei; Zhang, Shuo; Zhang, Xiaolin; Zhao, Guiling; Zhu, Haitao; Sweeney, Zachary K.

View on PubMed
A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1-IRF Complexes Science, 2012, ISSN: 0036-8075

Glasmacher, Elke; Agrawal, Smita; Chang, Abraham B; Murphy, Theresa L; Zeng, Wenwen; Vander Lugt, Bryan; Khan, Aly A; Ciofani, Maria; Spooner, Chauncey; Rutz, Sascha; Hackney, Jason; Nurieva, Roza; Escalante, Carlos R; Ouyang, Wenjun; Littman, Dan R; Murphy, Kenneth M; Singh, Harinder

View on PubMed
Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Chudasama, V.L.; Schaedeli Stark, F.; Harrold, J.M.; Tibbitts, J.; Girish, S.R.; Gupta, M.; Frey, N.; Mager, D.E.

View on PubMed
Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies Pharmaceutical Research, 2012, ISSN: 0724-8741

Yin, Sheng; Pastuskovas, Cinthia V; Khawli, Leslie A; Stults, John T

View on PubMed
Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 is Linked to TNF-ALPHA Pharmacology Toxicological Sciences, 2012, ISSN: 1096-0929

Erickson, Rebecca Ida; Tarrant, Jacqueline; Cain, Gary; Lewin-Koh, Sock-Cheng; Dybdal, Noel; Wong, Harvey; Blackwood, Elizabeth; West, Kristina; Steigerwalt, Ronald; Mamounas, Michael; Flygare, John A; Amemiya, Kenjie; Dambach, Donna; Fairbrother, Wayne J; Diaz, Dolores

View on PubMed
S1P1 inhibits sprouting angiogenesis during vascular development Development, 2012, ISSN: 0950-1991

Shoham, Adi Ben; Malkinson, Guy; Krief, Sharon; Shwartz, Yulia; Ely, Yona; Ferrara, Napoleone; Yaniv, Karina; Zelzer, Elazar

View on PubMed
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Liu, Yanqiu; Berendsen, Agnes D.; Jia, Shidong; Lotinun, Sutada; Baron, Roland; Ferrara, Napoleone; Olsen, Bjorn R.

View on PubMed
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Heffron, Timothy P.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Dotson, Jennafer; Edgar, Kyle; Goldsmith, Richard; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Ndubaku, Chudi; Nonomiya, Jim; Olivero, Alan G.; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Trapp, Sean; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin

View on PubMed
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer Nature Genetics, 2012, ISSN: 1061-4036

Rudin, Charles M.; Durinck, Steffen; Stawiski, Eric W.; Poirier, John T.; Modrusan, Zora; Shames, David S.; Bergbower, Emily A.; Guan, Yinghui; Shin, James; Guillory, Joseph; Rivers, Celina Sanchez; Foo, Catherine K.; Bhatt, Deepali; Stinson, Jeremy; Gnad, Florian; Haverty, Peter M.; Gentleman, Robert; Chaudhuri, Subhra; Janakiraman, Vasantharajan; Jaiswal, Bijay S.; Parikh, Chaitali; Yuan, Wenlin; Zhang, Zemin; Koeppen, Hartmut; Wu, Thomas D.; Stern, Howard M.; Yauch, Robert L.; Huffman, Kenneth E.; Paskulin, Diego D.; Illei, Peter B.; Varella-Garcia, Marileila; Gazdar, Adi F.; De Sauvage, Frederic J.; Bourgon, Richard; Minna, John D.; Brock, Malcolm V.; Seshagiri, Somasekar

View on PubMed
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Blake, James F.; Xu, Rui; Bencsik, Josef R.; Xiao, Dengming; Kallan, Nicholas C.; Schlachter, Stephen; Mitchell, Ian S.; Spencer, Keith L.; Banka, Anna L.; Wallace, Eli M.; Gloor, Susan L.; Martinson, Matthew; Woessner, Richard D.; Vigers, Guy P.A.; Brandhuber, Barbara J.; Liang, Jun; Safina, Brian S.; Li, Jun; Zhang, Birong; Chabot, Christine; Do, Steven; Lee, Leslie; Oeh, Jason; Sampath, Deepak; Lee, Brian B.; Lin, Kui; Liederer, Bianca M.; Skelton, Nicholas J.

View on PubMed
Recurrent R-spondin fusions in colon cancer Nature, 2012, ISSN: 0028-0836

Seshagiri, Somasekar; Stawiski, Eric W. ; Durinck, Steffen; Modrusan, Zora; Storm, Elaine E.; Conboy, Caitlin B.; Chaudhuri, Subhra; Guan, Yinghui; Janakiraman, Vasantharajan; Jaiswal, Bijay S.; Guillory, Joseph; Ha, Connie; Dijkgraaf, Gerrit J. P. ;Stinson, Jeremy; Gnad, Florian; Huntley, Melanie A.; Degenhardt, Jeremiah D.; Haverty, Peter M.; Bourgon, Richard; Wang, Weiru ; Koeppen, Hartmut; Gentleman, Robert; Starr, Timothy K.; Zhang, Zemin; Largaespada, David A.; Wu, Thomas D. ; de Sauvage, Frederic J.

View on PubMed
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Blood, 2012, ISSN: 0006-4971

Merino, Delphine; Khaw, Seong L.; Glaser, Stefan P.; Anderson, Daniel J.; Belmont, Lisa D.; Wong, Chihunt; Yue, Peng; Robati, Mikara; Phipson, Belinda; Fairlie, Walter D.; Lee, Erinna F.; Campbell, Kirsteen J.; Vandenberg, Cassandra J.; Cory, Suzanne; Roberts, Andrew W.; Ludlam, Mary J. C.; Huang, David C. S.; Bouillet, Philippe

View on PubMed
Real-time quantification of antibody-siRNA conjugate in serum by antigen-capture RT-PCR Analytical Biochemistry, 2012, ISSN: 0003-2697

Tan, Martha; Vernes, Jean-Michel; Chan, Joyce; Cuellar, Trinna L; Asundi, Aarati; Nelson, Christopher; Yip, Victor; Shen, Ben; Vandlen, Richard; Siebel, Christian; Gloria Meng, Y

View on PubMed
The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site Structure, 2012, ISSN: 0969-2126

de Leon-Boenig, Gladys; Bowman, Krista K; Feng, Jianwen A; Crawford, Terry; Everett, Christine; Franke, Yvonne; Oh, Angela; Stanley, Mark; Staben, Steven T; Starovasnik, Melissa A; Wallweber, Heidi J A; Wu, Jiansheng; Wu, Lawren C; Johnson, Adam R; Hymowitz, Sarah G

View on PubMed
Profiling Antibody Drug Conjugate Positional Isomers: A System-of-Equations Approach Analytical Chemistry, 2012, ISSN: 0003-2700

Le, Lan N; Moore, Jamie M R; Ouyang, Jun; Chen, Xiaoying; Nguyen, Mary D H; Galush, William J

View on PubMed
Molecular basis for negative regulation of the glucagon receptor Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Koth, Christopher M; Murray, Jeremy M; Mukund, Susmith; Madjidi, Azadeh; Minn, Alexandra; Clarke, Holly J; Wong, Terence; Chiang, Vicki; Luis, Elizabeth; Estevez, Alberto; Rondon, Jesus; Zhang, Yingnan; Hötzel, Isidro; Allan, Bernard B

View on PubMed
Effectiveness of First-Line Management Strategies for Stage I Follicular Lymphoma: Analysis of the National LymphoCare Study Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Friedberg, Jonathan W; Byrtek, Michelle; Link, Brian K; Flowers, Christopher; Taylor, Michael; Hainsworth, John; Cerhan, James R; Zelenetz, Andrew D; Hirata, Jamie; Miller, Thomas P

View on PubMed
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 Nature, 2012, ISSN: 0028-0836

Broz, Petr; Ruby, Thomas; Belhocine, Kamila; Bouley, Donna M.; Kayagaki, Nobuhiko; Dixit, Vishva M.; Monack, Denise M.

View on PubMed
Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Cirrincione-Dall, Georgina; Brennan, Barbara J.; Ballester-Sanchis, Rosa M.; Navarro, Mercidita T.; Davies, Brian E.

View on PubMed
Phosphorylation of NLRC4 is critical for inflammasome activation Nature, 2012, ISSN: 0028-0836

Qu, Yan; Misaghi, Shahram; Izrael-Tomasevic, Anita; Newton, Kim; Gilmour, Laurie L; Lamkanfi, Mohamed; Louie, Salina; Kayagaki, Nobuhiko; Liu, Jinfeng; Kömüves, László; Cupp, James E; Arnott, David; Monack, Denise; Dixit, Vishva M

View on PubMed
The genetics of type I interferon in systemic lupus erythematosus Current Opinion in Immunology, 2012, ISSN:

Bronson, Paola; Chaivorapol, Christina; Ortmann, Ward; Behrens, Timothy; Graham, Robert;

View on PubMed
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation Science, 2012, ISSN: 0036-8075

Dey, Anwesha; Seshasayee, Dhaya; Noubade, Rajkumar; French, Dorothy M; Liu, Jinfeng; Chaurushiya, Mira S; Kirkpatrick, Donald S; Pham, Victoria C; Lill, Jennie R; Bakalarski, Corey E; Wu, Jiansheng; Phu, Lilian; Katavolos, Paula; Lafave, Lindsay M; Abdel-Wahab, Omar; Modrusan, Zora; Seshagiri, Somasekar; Dong, Ken; Lin, Zhonghua; Balazs, Mercedesz; Suriben, Rowena; Newton, Kim; Hymowitz, Sarah; Garcia-Manero, Guillermo; Martin, Flavius; Levine, Ross L; Dixit, Vishva M

View on PubMed
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Murray, Jeremy M.; Sweeney, Zachary K.; Chan, Bryan K.; Balazs, Mercedesz; Bradley, Erin; Castanedo, Georgette; Chabot, Christine; Chantry, David; Flagella, Michael; Goldstein, David M.; Kondru, Rama; Lesnick, John; Li, Jun; Lucas, Matthew C.; Nonomiya, Jim; Pang, Jodie; Price, Stephen; Salphati, Laurent; Safina, Brian; Savy, Pascal P. A.; Seward, Eileen M.; Ultsch, Mark; Sutherlin, Daniel P.

View on PubMed
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature, 2012, ISSN:

Jonsson T; Atwal JK; Steinberg S; Snaedal J; Jonsson PV; Bjornsson S; Stefansson H; Sulem P; Gudbjartsson D; Maloney J; Hoyte K; Gustafson A; Liu Y; Lu Y; Bhangale T; Graham RR; Huttenlocher J; Bjornsdottir G; Andreassen OA; Jönsson EG; Palotie A; Behrens TW; Magnusson OT; Kong A; Thorsteinsdottir U; Watts RJ; Stefansson K.

View on PubMed
Pari passu dimers of dimers Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Sliwkowski, Mark;

View on PubMed
Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis Toxicological Sciences, 2012, ISSN:

Wong, Harvey; Budha, Nageshwar; West, Kristina; Blackwood, Elizabeth; Ware, Joseph; Yu, Ron; Darbonne, Walter; Gould, Stephen; Steigerwalt, Ronald; Erickson, Rebecca; Hop, Cornelis; LoRusso, Patricia; Eckhardt, Gail; Wagner, Andrew;Chan, Iris; Mamounas, Michael; Flygare, John; Fairbrother, Wayne

View on PubMed
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors Nature, 2012, ISSN:

Wilson, Timothy; Fridlyand, Jane; Yan, Yibing; Penuel, Elicia; Burton, Luciana; Chan, Emily; Peng, Jing; Lin, Eva; Wang, Yulei; Sosman, Jeff; Ribas, Antoni; Li, Jiang; Moffat, John; Sutherlin, Daniel; Koeppen, Hartmut; Merchant, Mark; Neve, Richard; Settleman, Jeff;

View on PubMed
Evaluation of an Accurate Mass Approach for the Simultaneous Detection of Drug and Metabolite Distributions via Whole-Body Mass Spectrometric Imaging Analytical Chemistry, 2012, ISSN: 0003-2700

Shahidi-Latham, Sheerin K.; Dutta, Sucharita M.; Conaway, Maria C. Prieto; Rudewicz, Patrick J.

View on PubMed
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair Blood, 2012, ISSN: 0006-4971

Willenborg, Sebastian; Lucas, Tina; Van Loo, Geert; Knipper, Johanna A.; Krieg, Thomas; Haase, Ingo; Brachvogel, Bent; Hammerschmidt, Matthias; Nagy, Andras; Ferrara, Napoleone; Pasparakis, Manolis; Eming, Sabine A.

View on PubMed
Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease Blood, 2012, ISSN: 0006-4971

Chantrathammachart, Pichika; Mackman, Nigel; Sparkenbaugh, Erica; Wang, Jian-Guo; Parise, Leslie V.; Kirchhofer, Daniel; Key, Nigel S.; Pawlinski, Rafal

View on PubMed
Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Pasqua, Adele E.; Ferrari, Frank D.; Hamman, Chris; Liu, Yanzhou; Crawford, James J.; Marquez, Rodolfo

View on PubMed
Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Zak, Mark; Mendonca, Rohan; Balazs, Mercedesz; Barrett, Kathy; Bergeron, Philippe; Blair, Wade S; Chang, Christine; Deshmukh, Gauri; Devoss, Jason; Dragovich, Peter S; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Gradl, Stefan; Hamman, Chris; Hanan, Emily J; Harstad, Eric; Hewitt, Peter R; Hurley, Christopher A; Jin, Tian; Johnson, Adam; Johnson, Tony; Kenny, Jane R; Koehler, Michael F T; Bir Kohli, Pawan; Kulagowski, Janusz J; Labadie, Sharada; Liao, Jiangpeng; Liimatta, Marya; Lin, Zhonghua; Lupardus, Patrick J; Maxey, Robert J; Murray, Jeremy M; Pulk, Rebecca; Rodriguez, Madeleine; Savage, Scott; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; Ultsch, Mark; van Abbema, Anne; Ward, Stuart I; Xiao, Ling; Xiao, Yisong

View on PubMed
Quantification and Characterization of Micrometer and Submicrometer Subvisible Particles in Protein Therapeutics by Use of a Suspended Microchannel Resonator. Analytical Chemistry, 2012, ISSN: 0003-2700

Patel, Ankit R; Lau, Doris; Liu, Jun

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells Blood, 2012, ISSN:

Chatterjee, Bithi; Smed-Sörensen, Anna; Cohn, Lillian; Chalouni, Cécile; Vandlen, Richard; Lee, Byoung-Chul; Widger, Jenifer; Keler, Tibor; Delamarre, Lélia; Mellman, Ira

View on PubMed
Identification and Characterization of Buried Unpaired Cysteines in a Recombinant Monoclonal IgG1 Antibody Analytical Chemistry, 2012, ISSN: 0003-2700

Zhang, Taylor; Zhang, Jennifer; Hewitt, Daniel; Ben Tran; Gao, Xiaoying; Qiu, Zhihua Julia; Tejada, Max; Gazzano-Santoro, Helene; Kao, Yung-Hsiang

View on PubMed
Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth. Cancer cell, 2012, ISSN: 1535-6108

Wilson, Nicholas S; Yang, Annie; Yang, Becky; Couto, Suzana; Stern, Howard; Gogineni, Alvin; Pitti, Robert; Marsters, Scot; Weimer, Robby M; Singh, Mallika; Ashkenazi, Avi

The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients British Journal of Clinical Pharmacology, 2012, ISSN: 0007-1188

Polson, Andrew G.; Fuji, Reina N.

View on PubMed
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway EMBO Journal, 2012, ISSN: 0261-4189

Zhuang, Guanglei; Wu, Xiumin; Jiang, Zhaoshi; Kasman, Ian; Yao, Jenny; Guan, Yinghui; Oeh, Jason; Modrusan, Zora; Bais, Carlos; Sampath, Deepak; Ferrara, Napoleone

View on PubMed
Reversible modification of APC with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Tran, Hoanh; Polakis, Paul

View on PubMed
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Argaw, Azeb Tadesse; Asp, Linnea; Zhang, Jingya; Navrazhina, Kristina; Pham, Trinh; Mariani, John N.; Mahase, Sean; Dutta, Dipankar J.; Seto, Jeremy; Kramer, Elisabeth G.; Ferrara, Napoleone; Sofroniew, Michael V.; John, Gareth R.

View on PubMed
Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Budha, N R; Frymoyer, A; Smelick, G S; Jin, J Y; Yago, M R; Dresser, M J; Holden, S N; Benet, L Z; Ware, J A

View on PubMed
Reply to "On the differentiation of mouse IgE(+) cells" Nature Immunology, 2012, ISSN: 1529-2908

Talay, Oezcan; Yan, Donghong; Brightbill, Hans D; Straney, Elizabeth E M; Zhou, Meijuan; Ladi, Ena; Lee, Wyne P; Egen, Jackson G; Austin, Cary D; Xu, Min; Wu, Lawren C

View on PubMed
Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection Analytical Chemistry, 2012, ISSN: 0003-2700

Michels, David A; Tu, Andrea W; McElroy, Will; Voehringer, David; Salas-Solano, Oscar

View on PubMed
Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding PLoS ONE, 2012, ISSN: 1932-6203

Nakamura, Gerald R; Fonseca, Dora P A J; O'Rourke, Sara M; Vollrath, Aaron L; Berman, Phillip W

View on PubMed
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nature Chemical Biology, 2012, ISSN: 1552-4450

Stanger, Karen; Steffek, Micah; Zhou, Lijuan; Pozniak, Christine D; Quan, Clifford; Franke, Yvonne; Tom, Jeff; Tam, Christine; Elliott, J Michael; Lewcock, Joseph W; Zhang, Yingnan; Murray, Jeremy; Hannoush, Rami N

View on PubMed
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Heald, Robert A.; Jackson, Philip; Savy, Pascal; Jones, Mark; Gancia, Emanuela; Burton, Brenda; Newman, Richard; Boggs, Jason; Chan, Emily; Chan, Jocelyn; Choo, Edna; Merchant, Mark; Rudewicz, Patrick; Ultsch, Mark; Wiesmann, Christian; Yue, Qin; Belvin, Marcia; Price, Steve

View on PubMed
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma New England Journal of Medicine, 2012, ISSN: 1533-4406

Sekulic, Aleksandar; Migden, Michael R.; Oro, Anthony E.; Dirix, Luc; Lewis, Karl D.; Hainsworth, John D.; Solomon, James A.; Yoo, Simon; Arron, Sarah T.; Friedlander, Philip A.; Marmur, Ellen; Rudin, Charles M.; Chang, Anne Lynn S.; Low, Jennifer A.; Mackey, Howard M.; Yauch, Robert L.; Graham, Richard A.; Reddy, Josina C.; Hauschild, Axel

FOXO3a and β-catenin co-localization: double trouble in colon cancer? Nature Medicine, 2012, ISSN: 1078-8956

Yan, Yibing; Lackner, Mark R

View on PubMed
Structural and Functional Analysis of HtrA1 and Its Subdomains Structure, 2012, ISSN: 0969-2126

Eigenbrot, Charles; Ultsch, Mark; Lipari, Michael T.; Moran, Paul; Lin, S. Jack; Ganesan, Rajkumar; Quan, Clifford; Tom, Jeffrey; Sandoval, Wendy; Campagne, Menno van Lookeren; Kirchhofer, Daniel

View on PubMed
Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b + Gr1 + cells: Key role of Stat3 signaling Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Qu, Xueping; Zhuang, Guanglei; Yu, Lanlan; Meng, Gloria; Ferrara, Napoleone

View on PubMed
A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2 -Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Krop, Ian E; Lorusso, Patricia; Miller, Kathy D; Modi, Shanu; Yardley, Denise; Rodriguez, Gladys; Guardino, Ellie; Lu, Michael; Zheng, Maoxia; Girish, Sandhya; Amler, Lukas; Winer, Eric P; Rugo, Hope S

View on PubMed
Origin of Immunoglobulin Isotype Switching Current Biology, 2012, ISSN: 0960-9822

Zhu, Catherine; Lee, Victor; Finn, Alyssa; Senger, Kate; Zarrin, Ali A.; Du Pasquier, Louis; Hsu, Ellen

View on PubMed
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Ma, Xiaolei; Helgason, Elizabeth; Phung, Qui T.; Quan, Clifford L.; Iyer, Rekha S.; Lee, Michelle W.; Bowman, Krista K.; Starovasnik, Melissa A.; Dueber, Erin C.

View on PubMed
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Chen, Youjun; Chalouni, Cecile; Tan, Christine; Clark, Robyn; Venook, Rayna; Ohri, Rachana; Raab, Helga; Firestein, Ron; Mallet, William; Polakis, Paul;

View on PubMed
Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery Drug Metabolism and Disposition, 2012, ISSN:

Liu, Xingrong; Ding, Xiao; Deshmukh, Gauri; Liederer, Bianca M; Hop, Cornelis;

View on PubMed
Clinical Implications of Pathophysiological and Demographic Covariates on the Population Pharmacokinetics of Trastuzumab Emtansine, a HER2-Targeted Antibody-Drug Conjugate, in Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Pharmacology, 2012, ISSN: 0091-2700

Gupta, Manish; LoRusso, Patricia M; Wang, Bei; Yi, Joo-Hee; Burris, Howard A; Beeram, Muralidhar; Modi, Shanu; Chu, Yu-Waye; Agresta, Samuel; Klencke, Barbara; Joshi, Amita; Girish, Sandhya;

View on PubMed
Quantification of Antiangiogenic and Antivascular Drug Activity by Kinetic Analysis of DCE-MRI Data Clinical Pharmacology and Therapeutics, 2012, ISSN: 0009-9236

Ferl, Greg; Port, Ruediger;

View on PubMed
Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling. Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Chen, Huifen; Chan, Bryan K; Drummond, Jason; Estrada, Anthony A; Gunzner-Toste, Janet; Liu, Xingrong; Liu, Yichin; Moffat, John; Shore, Daniel; Sweeney, Zachary K; Tran, Thuy; Wang, Shumei; Zhao, Guiling; Zhu, Haitao; Burdick, Daniel J

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models PLoS One, 2012, ISSN: 1932-6203

French, Dorothy M; Lin, Benjamin C; Wang, Manping; Adams, Camellia; Shek, Theresa; Hotzel, Kathy; Bolon, Brad; Ferrando, Ronald; Blackmore, Craig; Schroeder, Kurt; Rodriguez, Luis A; Hristopoulos, Maria; Venook, Rayna; Ashkenazi, Avi; Desnoyers, Luc R

View on PubMed
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt Science Signaling, 2012, ISSN: 1937-9145

Lin, Kui; Lin, Jie; Wu, Wen-I; Ballard, Joshua; Lee, Brian B.; Gloor, Susan L.; Vigers, Guy P. A.; Morales, Tony H.; Friedman, Lori S.; Skelton, Nicholas; Brandhuber, Barbara J. ;

View on PubMed
Bevacizumab in Combination With Chemotherapy as First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Cutsem, Eric Van; Haas, Sanne de; Kang, Yoon-Koo; Ohtsu, Atsushi; Tebbutt, Niall C; Xu, Jian Ming; Yong, Wei Peng; Langer, Bernd; Delmar, Paul; Scherer, Stefan J; Shah, Manish A;

View on PubMed
Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Sun, Yonglian; Senger, Kate; Baginski, Tomasz K; Mazloom, Anita; Chinn, Yvonne; Pantua, Homer; Hamidzadeh, Kajal; Ramani, Sree Ranjani; Luis, Elizabeth; Tom, Irene; Sebrell, Andrew; Quinones, Gabriel; Ma, Yan; Mukhyala, Kiran; Sai, Tao; Ding, Jiabing; Haley, Benjamin; Shadnia, Hooman; Kapadia, Sharookh B; Gonzalez, Lino C; Hass, Philip E; Zarrin, Ali A

View on PubMed
Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes PLoS ONE, 2012, ISSN: 1932-6203

Wallin, Jeffrey J; Guan, Jane; Edgar, Kyle A; Zhou, Wei; Francis, Ross; Torres, Anthony C; Haverty, Peter M; Eastham-Anderson, Jeffrey; Arena, Sabrina; Bardelli, Alberto; Griffin, Sue; Goodall, John E; Grimshaw, Kyla M; Hoeflich, Klaus P; Torrance, Christopher; Belvin, Marcia; Friedman, Lori S

View on PubMed
Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis Current Opinion in Genetics & Development, 2012, ISSN: 0959-437X

Yauch, Robert L; Settleman, Jeff

View on PubMed
Translation levels control multi-spanning membrane protein expression PLoS ONE, 2012, ISSN: 1932-6203

Kim, Hok Seon; Ernst, James A; Brown, Cecilia; Bostrom, Jenny; Fuh, Germaine; Lee, Chingwei V; Huang, Arthur; Vandlen, Richard L; Yansura, Daniel G

View on PubMed
OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Journal of Clinical Oncology, 2012, ISSN: 0732-183X

Aghajanian, Carol; Blank, Stephanie V; Goff, Barbara A; Judson, Patricia L; Teneriello, Michael G; Husain, Amreen; Sovak, Mika A; Yi, Jing; Nycum, Lawrence R;

View on PubMed
Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis Developmental Cell, 2012, ISSN: 1534-5807

Fong, Abraham P; Yao, Zizhen; Zhong, Jun Wen; Cao, Yi; Ruzzo, Walter L; Gentleman, Robert C; Tapscott, Stephen J;

View on PubMed
Inhibiting alternative pathway complement activation by targeting the factor D exosite Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Katschke Jr, Kenneth J; Wu, Ping; Ganesan, Rajkumar; Kelley, Robert F; Mathieu, Mary A; Hass, Philip E; Murray, Jeremy; Kirchhofer, Daniel; Wiesmann, Christian; Campagne, Menno van Lookeren;

View on PubMed
Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R Structure, 2012, ISSN: 0969-2126

Ma, Xiaolei; Lin, Wei Yu; Chen, Yongmei; Stawicki, Scott; Mukhyala, Kiran; Wu, Yan; Martin, Flavius; Bazan, J. Fernando; Starovasnik, Melissa A;

View on PubMed
Cancer: Clinical trials unite mice and humans Nature, 2012, ISSN: 0028-0836

Johnson, Leisa;

View on PubMed
Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors Science Signaling, 2012, ISSN: 1945-0877

Varfolomeev, Eugene; Goncharov, Tatiana; Maecker, Heather; Zobel, Kerry; Kömüves, László G; Deshayes, Kurt; Vucic, Domagoj;

View on PubMed
Small-Molecule Ligands Bind to a Distinct Pocket in Ras and Inhibit SOS-Mediated Nucleotide Exchange Activity Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Fang, Guowei; Wang, Weiru; Rudolph, Joachim; Jackson, Peter K.; Mellman, Ira; Starovasnik, Melissa A.; Giannetti, Anthony M.; Wu, Jiansheng; Bowman, Krista K.; Ludlam, Mary J. C.; Stokoe, David; Malek, Shiva; Pan, Borlan; Fauber, Benjamin P.; Skelton, Nicholas J.; Anderson, Daniel J.; Pitts, Keith; Oh, Angela; Garrenton, Lindsay S.; Maurer, Till

View on PubMed
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

Grogan, Jane L.; Eaton, Dan L.; Bazan, J. Fernando; Wiesmann, Christian; Comps-Agrar, Laëtitia; Yin, Jianping; Rouge, Lionel; Yu, Xin; Harden-Bowles, Kristin; Stengel, Katharina F.

View on PubMed
Drug-Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug-Drug Interaction Prediction Pharmaceutical Research, 2012, ISSN: 0724-8741

Kenny, Jane R; Mukadam, Sophie; Zhang, Chenghong; Tay, Suzanne; Collins, Carol; Galetin, Aleksandra; Khojasteh, S. Cyrus;

View on PubMed
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Flygare, John A; Beresini, Maureen; Budha, Nageshwar; Chan, Helen; Chan, Iris T; Cheeti, Sravanthi; Cohen, Frederick; Deshayes, Kurt; Doerner, Karl; Eckhardt, S. Gail; Elliott, Linda O; Feng, Bainian; Franklin, Matthew C; Reisner, Stacy Frankovitz; Gazzard, Lewis; Halladay, Jason; Hymowitz, Sarah G; La, Hank; LoRusso, Patricia; Maurer, Brigitte; Murray, Lesley; Plise, Emile; Quan, Clifford; Stephan, Jean-Philippe; Young, Shin G; Tom, Jeffrey; Tsui, Vickie; Um, Joanne; Varfolomeev, Eugene; Vucic, Domagoj; Wagner, Andrew J; Wallweber, Heidi J. A; Wang, Lan; Ware, Joseph; Wen, Zhaoyang; Wong, Harvey; Wong, Jonathan M; Wong, Melisa; Wong, Susan; Yu, Ron; Zobel, Kerry; Fairbrother, Wayne J;

View on PubMed
In Vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease PLoS ONE, 2012, ISSN:

Chiang, Eugene Y; Kolumam, Ganesh; McCutcheon, Krista M; Young, Judy; Lin, Zhonghua; Balazs, Mercedesz; Grogan, Jane L;

View on PubMed
Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses Pharmaceutical Research, 2012, ISSN: 0724-8741

Abbas, Shermeen A; Sharma, Vikas K; Patapoff, Thomas W; Kalonia, Devendra S;

View on PubMed
Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells PLoS Pathogens, 2012, ISSN: 1553-7366

Smed-Sörensen, Anna; Chalouni, Cécile; Chatterjee, Bithi; Cohn, Lillian; Blattmann, Peter; Nakamura, Norihiro; Delamarre, Lélia; Mellman, Ira;

View on PubMed
An evolutionary conserved PILRα domain mediates its interaction with diverse sialylated ligands Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Sun, Yonglian; Senger, Kate; Baginski, Tomasz K; Mazloom, Anita; Chinn, Yvonne; Pantua, Homer; Hamidzadeh , Kajal; Ramani, Sree Ranjani; Luis, Elizabeth; Tom, Irene; Sebrell, Andrew; Quinones, Gabriel; Ma, Yan; Mukhyala, Kiran; Sai, Tao; Ding, Jiabing; Haley, Benjamin; Shadnia, Hooman; Kapadia, Sharookh B; Gonzalez, Lino C; Hass, Philip E; Zarrin, Ali A;

View on PubMed
Engineering upper hinge improves stability and effector function of a human IgG1 Journal of Biological Chemistry, 2012, ISSN: 0021-9258

Yan, Boxu; Boyd, Daniel; Kaschak, Timothy; Tsukuda, Joni; Shen, Amy; Lin, Yuwen; Chung, Shan; Gupta, Priyanka; Kamath, Amrita; Wong, Anne; Vernes, Jean-Michel; Meng, Gloria Y.; Totpal, Klara; Schaefer, Gabriele; Jiang, Guoying; Nogal, Bartek; Emery, Craig; Vanderlaan, Martin; Carter, Paul; Harris, Reed; Amanullah, Ashraf

View on PubMed
An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo PloS ONE, 2012, ISSN:

Cleopatra Kozlowski ; Robby M Weimer

View on PubMed
IgE(+) memory B cells and plasma cells generated through a germinal-center pathway Nature Immunology, 2012, ISSN: 1529-2908

Talay, Oezcan; Yan, Donghong; Brightbill, Hans D; Straney, Elizabeth E M; Zhou, Meijuan; Ladi, Ena; Lee, Wyne P; Egen, Jackson G; Austin, Cary D; Xu, Min; Wu, Lawren C

View on PubMed
Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

Mathieu, Simon; Gradl, Stefan N; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W; Buckmelter, Alex J; Choo, Edna F; Dinkel, Victoria; Gloor, Susan L; Gould, Stephen E; Hansen, Joshua D; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R; Moreno, David; Ran, Yingqing; Voegtli, Walter C; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim;

View on PubMed
Death Receptors DR6 and TROY Regulate Brain Vascular Development Developmental cell, 2012, ISSN: 1534-5807

Tam, Stephen J; Richmond, David L; Kaminker, Joshua S; Modrusan, Zora; Martin-McNulty, Baby; Cao, Tim C; Weimer, Robby M; Carano, Richard A D; van Bruggen, Nick; Watts, Ryan J

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling Nature Immunology, 2012, ISSN: 1529-2908

Seiler, Michael P.; Mathew, Rebecca; Liszewski, Megan K.; Spooner, Chauncey; Barr, Kenneth; Meng, Fanyong; Singh, Harinder; Bendelac, Albert

View on PubMed
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells Development, 2012, ISSN: 0950-1991

VanDussen, Kelli L.; Carulli, Alexis J.; Keeley, Theresa M.; Dempsey, Peter J.; Samuelson, Linda C.; Patel, Sanjeevkumar R.; Maillard, Ivan; Puthoff, Brent J.; Magness, Scott T.; Tran, Ivy T.; Kolterud, Åsa; Grosse, Ann S.; Gumucio, Deborah L.; Ernst, Stephen A.; Siebel, Christian; Tsai, Yu-Hwai

View on PubMed
Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin Journal of Clinical Investigation, 2012, ISSN: 0021-9738

Owens III, A. Phillip; Antoniak, Silvio; Williams, Julie C.; Wang, Jianguo; Mackman, Nigel; Passam, Freda H.; Furie, Barbara C.; Furie, Bruce; Marshall, Stephanie M.; McDaniel, Allison L.; Rudel, Lawrence; Temel, Ryan E.; Hubbard, Brian K.; Johns, Douglas G.; Dutton, Julie-Ann; Moriarty, Patrick M.; Tobias, Peter S.; Curtiss, Linda K.; Daugherty, Alan; Kirchhofer, Daniel; Luyendyk, James P.; Nagarajan, Shanmugam

View on PubMed
High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency PLoS Genetics, 2012, ISSN: 1553-7390

Ferreira, Ricardo C; Pan-Hammarström, Qiang; Graham, Robert R; Fontán, Gumersindo; Lee, Annette T; Ortmann, Ward; Wang, Ning; Urcelay, Elena; Fernández-Arquero, Miguel; Núñez, Concepción; Jorgensen, Gudmundur; Ludviksson, Björn R; Koskinen, Sinikka; Haimila, Katri; Padyukov, Leonid; Gregersen, Peter K; Hammarström, Lennart; Behrens, Timothy W

View on PubMed
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates Nature Biotechnology, 2012, ISSN: 1087-0156

Shen, Ben-Quan; Xu, Keyang; Liu, Luna; Raab, Helga; Bhakta, Sunil; Kenrick, Margaret; Parsons-Reponte, Kathryn L; Tien, Janet; Yu, Shang-Fan; Mai, Elaine; Li, Dongwei; Tibbitts, Jay; Baudys, Jakub; Saad, Ola M; Scales, Suzie J; McDonald, Paul J; Hass, Philip E; Eigenbrot, Charles; Nguyen, Trung; Solis, Willy A; Fuji, Reina N; Flagella, Kelly M; Patel, Darshana; Spencer, Susan D; Khawli, Leslie A; Ebens, Allen; Wong, Wai Lee; Vandlen, Richard; Kaur, Surinder; Sliwkowski, Mark X; Scheller, Richard H; Polakis, Paul; Junutula, Jagath R

View on PubMed
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer Nature Medicine, 2012, ISSN: 1078-8956

Montagut, Clara; Dalmases, Alba; Gallen, Manuel; Bellmunt, Joaquim; Rovira, Ana; Albanell, Joan; Bellosillo, Beatriz; Pairet, Silvia; Serrano, Sergi; Iglesias, Mar; Salido, Marta; Crespo, Marta; Bosch, Francesc; Marsters, Scot; Tsai, Siao Ping; Somasekar, Seshagiri; Settleman, Jeff; Minoche, André; Himmelbauer, Heinz

View on PubMed
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation Nature Immunology, 2012, ISSN: 1529-2908

Ochiai, Kyoko; Maienschein-Cline, Mark; Mandal, Malay; Triggs, Joseph R.; Bertolino, Eric; Sciammas, Roger; Dinner, Aaron R.; Clark, Marcus R.; Singh, Harinder

View on PubMed
Antibody-mediated Inhibition of Fibroblast Growth Factor-19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys Toxicological Sciences, 2012, ISSN: 1096-0929

Pai, Rama; French, Dorothy; Ma, Ning; Hotzel, Kathy; Plise, Emile; Salphati, Laurent; Setchell, Kenneth D R; Ware, Joseph; Lauriault, Veronique; Leah, Schutt; Hartley, Dylan; Dambach, Donna

View on PubMed
Protecting Group Free, Stereocontrolled Synthesis of beta-Halo-enamides Journal of Organic Chemistry, 2012, ISSN: 0022-3263

Pasqua, Adele E; Crawford, James J; Long, De-Liang; Marquez, Rodolfo;

View on PubMed
Signaling: An oxysterol ligand for Smoothened Nature Chemical Biology, 2012, ISSN: 1552-4450

Sharpe, Hayley J.; De Sauvage, Frederic J.

View on PubMed
DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy Developmental Cell, 2012, ISSN: 1534-5807

Geng, Linda N.; Snider, Lauren; Fong, Abraham P.; Cech, Jennifer N.; Young, Janet M.; Tapscott, Stephen J.; Yao, Zizhen; vanderMaarel, Silvere M.; Ruzzo, Walter L.; Gentleman, Robert C.; Tawil, Rabi

View on PubMed
Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural & Molecular Biology, 2012, ISSN: 1545-9985

Huang, Oscar W; Ma, Xiaolei; Yin, Jianping; Flinders, Jeremy; Maurer, Till; Kayagaki, Nobuhiko; Phung, Qui; Bosanac, Ivan; Arnott, David; Dixit, Vishva M; Hymowitz, Sarah G; Starovasnik, Melissa A; Cochran, Andrea G

View on PubMed
A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C PLoS ONE, 2012, ISSN: 1932-6203

Mintzer, Robert; Ramaswamy, Sreemathy; Shah, Kinjalkumar; Hannoush, Rami N; Pozniak, Christine D; Cohen, Frederick; Zhao, Xianrui; Plise, Emile; Lewcock, Joseph W; Heise, Christopher E

View on PubMed
Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis Science, 6 Jan 2012, v335(6064), p89-92, ISSN: 0036-8075, eISSN: 1095-9203

Hsu, Chia-Lin; Lin, Weiyu; Seshasayee, Dhaya; Chen, Yung-Hsiang; Ding, Xiao; Lin, Zhonghua; Suto, Eric; Huang, Zhiyu; Lee, Wyne P; Park, Hyunjoo; Xu, Min; Sun, Mei; Rangell, Linda; Lutman, Jeff L; Ulufatu, Sheila; Stefanich, Eric; Chalouni, Cecile; Sagolla, Meredith; Diehl, Lauri; Fielder, Paul; Dean, Brian; Balazs, Mercedesz; Martin, Flavius

View on PubMed
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain Nature Cell Biology, 2012, ISSN: 1465-7392

Chih, Ben; Peterson, Andrew S.; Liu, Peter; Chinn, Yvonne; Hass, Philip E.; Sandoval, Wendy; Chalouni, Cecile; Komuves, Laszlo G.

View on PubMed
Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury Nature Medicine, 2012, ISSN: 1078-8956

Ertürk, Ali

View on PubMed
The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly Cell, 26 Dec 2011, v147(6), p1309-23, ISSN: 0092-8674

Torres, Jorge Z; Summers, Matthew K; Peterson, David; Brauer, Matthew J; Lee, James; Senese, Silvia; Gholkar, Ankur A; Lo, Yu-Chen; Lei, Xingye; Jung, Kenneth; Anderson, David C; Davis, David P; Belmont, Lisa; Jackson, Peter K

View on PubMed
The A-MYSM Power of Deubiquitinases Immunity, 23 Dec 2011, v35(6), p847-849, ISSN: 1074-7613

Demarco, Ignacio A.; Singh, Harinder

View on PubMed
Cancer immunotherapy comes of age Nature, 21 Dec 2011, v480, p480-489, ISSN: 1476-4687

Mellman, Ira; Coukos, George; Dranoff, Glenn

View on PubMed
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 Science Translational Medicine, 2011, ISSN: 1946-6234

Wu AL; Kolumam G; Stawicki S; Chen Y; Li J; Zavala-Solorio J; Phamluong K; Feng B; Li L; Marsters S; Kates L; van Bruggen N; Leabman M; Wong A; West D; Stern H; Luis E; Kim HS; Yansura D; Peterson AS; Filvaroff E; Wu Y; Sonoda J

View on PubMed
Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition PLoS ONE, 2011, ISSN: 1932-6203

Shankar, Jata; Clemons, Karl V.; Monteiro, Jomar P.; Mirels, Laurence F.; Stevens, David A.; Wu, Thomas D.

View on PubMed
Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 Science Translational Medicine, 2011, ISSN: 1946-6234

Wu, Ai-Luen; Phamluong, Khanhky; Feng, Bo; Peterson, Andrew S.; Sonoda, Junichiro; Kolumam, Ganesh; Zavala-Solorio, Jose; Kates, Lance; Van Bruggen, Nicholas; Stawicki, Scott; Chen, Yongmei; Kim, Hok Seon; Yansura, Daniel; Wu, Yan; Li, Jun; Marsters, Scot; Filvaroff, Ellen; Li, Li; Leabman, Maya; West, David; Wong, Anne; Stern, Howard; Luis, Elizabeth

View on PubMed
Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 Cancer Cell, 2011, ISSN: 1535-6108

Junttila, Teemu T.; Akita, Robert W.; Parsons, Kathryn; Fields, Carter; Lewis Phillips, Gail D.; Friedman, Lori S.; Sampath, Deepak; Sliwkowski, Mark X.

View on PubMed
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap PLoS Genetics, 2011, ISSN: 1553-7390

Ramos, Paula S.; Criswell, Lindsey A.; Chung, Sharon A.; Moser, Kathy L.; Kelly, Jennifer A.; Gaffney, Patrick M.; Alarcón-Riquelme, Marta E.; Comeau, Mary E.; Williams, Adrienne H.; Pajewski, Nicholas M.; Langefeld, Carl D.; Graham, Robert R.; Zidovetzki, Raphael; Kaufman, Kenneth M.; Harley, John B.; Jacob, Chaim O.; Vyse, Timothy J.; Tsao, Betty P.; Kimberly, Robert P.

View on PubMed
Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation Journal of Biological Chemistry, v286(48), p41852-41861, ISSN: 0021-9258

Mao, Yifan; Shang, Yonglei; Zha, Jiping; Pham, Victoria C.; Ernst, James A.; Lill, Jennie R.; Scales, Suzie J.

View on PubMed
BEAM: A Randomized Phase II Study Evaluating the Activity of Bevacizumab in Combination With Carboplatin Plus Paclitaxel in Patients With Previously Untreated Advanced Melanoma Journal of Clinical Oncology, 28 Nov 2011, ISSN: 1527-7755.

Kim, Kevin B; Sosman, Jeffrey A; Fruehauf, John P; Linette, Gerald P; Markovic, Svetomir N; McDermott, David F; Weber, Jeffrey S; Nguyen, Hoa; Cheverton, Peter; Chen, Daniel; Peterson, Amy C; Carson, William E 3rd; O, Day Steven J

View on PubMed
Rational Design of Phosphoinositide 3-Kinase alpha Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase beta Isoform Journal of Medicinal Chemistry, 24 Nov 2011, vol. 54, no. 22, p. 7815-33, ISSN: 1520-4804

Heffron, Timothy P; Wei, Binqing; Olivero, Alan; Staben, Steven T; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing Yan

View on PubMed
Lymphangiogenesis is required for pancreatic islet inflammation and diabetes PLoS One, 23 Nov 2011, v6(11), pe28023, ISSN: 1932-6203

Yin, Na; Lal, Girdhari; Xu, Jiangnan; Ding, Yaozhong; Bromberg, Jonathan S.; Zhang, Nan; Yan, Minhong

View on PubMed
Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial The Lancet, 19 Nov 2011, V378, N9805, pp 1779-1787, ISSN: 0140-6736

Kappos, Ludwig; Li, David; Calabresi, Peter A; O, Connor Paul; Bar, Or Amit; Barkhof, Frederik; Yin, Ming; Leppert, David; Glanzman, Robert; Tinbergen, Jeroen; Hauser, Stephen L

View on PubMed
It takes two to tango: a new couple in the family of ubiquitin-editing complexes Nature Immunology, 16 Nov 2011, vol.12, no.12, p.1133-5, ISSN: 1529-2916

Wertz, Ingrid E

View on PubMed
The heart endocardium is derived from vascular endothelial progenitors. Development, 1 Nov 2011, V138, N21, pp 4777-4787. ISSN: 0950-1991.

Milgrom, Hoffman Michal; Harrelson, Zachary; Ferrara, Napoleone; Zelzer, Elazar; Evans, Sylvia M; Tzahor, Eldad

View on PubMed
Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q. PloS one, {PLoS-ONE}, 2011 (epub: 12 Oct 2011), vol. 6, no. 10, p. e25038, ISSN: 1932-6203.

Pidasheva, Svetlana; Trifari, Sara; Phillips, Anne; Hackney, Jason A; Ma, Yan; Smith, Ashley; Sohn, Sue J; Spits, Hergen; Little, Randall D; Behrens, Timothy W; Honigberg, Lee; Ghilardi, Nico; Clark, Hilary F

View on PubMed
Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin. Journal of Clinical Oncology, 24 Oct 2011, ISSN: 1527-7755.

Lai, Albert; Kharbanda, Samir; Pope, Whitney B; Tran, Anh; Solis, Orestes E; Peale, Franklin; Forrest, William F; Pujara, Kanan; Carrillo, Jose A; Pandita, Ajay; Ellingson, Benjamin M; Bowers, Chauncey W; Soriano, Robert H; Schmidt, Nils O; Mohan, Sankar; Yong, William H; Seshagiri, Somasekar; Modrusan, Zora; Jiang, Zhaoshi; Aldape, Kenneth D; Mischel, Paul S; Liau, Linda M; Escovedo, Cameron J; Chen, Weidong; Nghiemphu, Phioanh Leia; James, C David; Prados, Michael D; Westphal, Manfred; Lamszus, Katrin; Cloughesy, Timothy; Phillips, Heidi S

View on PubMed
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 21 Oct 2011, vol. 334, no. 6054, p. 376-80, ISSN: 1095-9203.

Dueber, Erin C; Schoeffler, Allyn J; Lingel, Andreas; Elliott, J Michael; Fedorova, Anna V; Giannetti, Anthony M; Zobel, Kerry; Maurer, Brigitte; Varfolomeev, Eugene; Wu, Ping; Wallweber, Heidi J A; Hymowitz, Sarah G; Deshayes, Kurt; Vucic, Domagoj; Fairbrother, Wayne J

View on PubMed
Impaired FcepsilonRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins Blood, 20 October 2011, vol. 118, no. 16, p. 4377-4383, eISSN: 1528-0020, ISSN: 0006-4971.

Hazenbos, Wouter L W; Wu, Ping; Eastham, Anderson Jeffrey; Kinoshita, Taroh; Brown, Eric J

View on PubMed
A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies Cancer Cell, 18 Oct 2011, v20(4), p.472-86, ISSN: 1878-3686

Gabriele Schaefer; Lauric Haber; Lisa M. Crocker; Steven Shia; Lily Shao; Donald Dowbenko; Klara Totpal; Anne Wong; Chingwwei V. Lee; Scott Stawicki; Robyn Clark; Carter Fields; Gail D. Lewis Phillips; Rodney A. Prell; Dimitry M. Danilenko; Yvonne Franke; Jean-Philippe Stephan; Jiyoung Hwang; Yan Wu; Jenny Bostrom, Mark X. Sliwkowski; Germaine Fuh; Charles Eigenbrot

View on PubMed
Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non-Small-Cell Lung Cancer. Journal of Clinical Oncology, 17 Oct 2011, ISSN: 1527-7755.

Soria, Jean Charles; Mark, Zsuzsanna; Zatloukal, Petr; Szima, Barna; Albert, Istvan; Juhasz, Erzsebet; Pujol, Jean Louis; Kozielski, Jerzy; Baker, Nigel; Smethurst, Dominic; Hei, Yong Jiang; Ashkenazi, Avi; Stern, Howard; Amler, Lukas; Pan, Yang; Blackhall, Fiona

View on PubMed
Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry Analytical Chemistry, Oct 17, 2011, vol. 83, no. 22, p. 8501-8, ISSN: 1520-6882.

Zhang, Liangyi; Lilyestrom, Wayne; Li, Charlene; Scherer, Thomas; van, Reis Robert; Zhang, Boyan

View on PubMed
Non-canonical inflammasome activation targets caspase-11. Nature, 16 Oct 2011, ISSN: 1476-4687.

Kayagaki, Nobuhiko; Warming, Soeren; Lamkanfi, Mohamed; Walle, Lieselotte Vande; Louie, Salina; Dong, Jennifer; Newton, Kim; Qu, Yan; Liu, Jinfeng; Heldens, Sherry; Zhang, Juan; Lee, Wyne P; Roose, Girma Merone; Dixit, Vishva M

View on PubMed
Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. Nature immunology, 16 Oct 2011, ISSN: 1529-2916.

Rutz, Sascha; Noubade, Rajkumar; Eidenschenk, Celine; Ota, Naruhisa; Zeng, Wenwen; Zheng, Yan; Hackney, Jason; Ding, Jiabing; Singh, Harinder; Ouyang, Wenjun

View on PubMed
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells Nature Immunology, 2011, ISSN: 0022-1767

Rutz, Sascha; Noubade, Rajkumar; Eidenschenk, Celine; Singh, Harinder; Ouyang, Wenjun

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL. Cancer Cell, 2011, V20, N3, SEP 13, pp 357-369. ISSN: 1535-6108.

Mali, Raghuveer Singh; Ramdas, Baskar; Ma, Peilin; Shi, Jianjian; Munugalavadla, Veerendra; Sims, Emily; Wei, Lei; Vemula, Sasidhar; Nabinger, Sarah C; Goodwin, Charles B; Chan, Rebecca J; Traina, Fabiola; Visconte, Valeria; Tiu, Ramon V; Lewis, Timothy A; Stern, Andrew M; Wen, Qiang; Crispino, John D; Boswell, H Scott; Kapur, Reuben

View on PubMed
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nature Immunology, 12 Oct 2011, ISSN: 1529-2916.

Ramirez, Carrozzi Vladimir; Sambandam, Arivazhagan; Luis, Elizabeth; Lin, Zhongua; Jeet, Surinder; Lesch, Justin; Hackney, Jason; Kim, Janice; Zhou, Meijuan; Lai, Joyce; Modrusan, Zora; Sai, Tao; Lee, Wyne; Xu, Min; Caplazi, Patrick; Diehl, Lauri; de Voss, Jason; Balazs, Mercedesz; Gonzalez, Lino Jr; Singh, Harinder; Ouyang, Wenjun; Pappu, Rajita

View on PubMed
Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (m TOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer Journal of Medicinal Chemistry, 7 Oct 2011, ISSN: 1520-4804.

Sutherlin, Daniel P; Bao, Linda; Berry, Megan; Castanedo, Georgette; Chuckowree, Irina; Dotson, Jenna; Folks, Adrian; Friedman, Lori; Goldsmith, Richard; Gunzner, Janet; Heffron, Timothy; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Murray, Jeremy; Nonomiya, Jim; Pang, Jodie; Pegg, Niel; Prior, Wei Wei; Rouge, Lionel; Salphati, Laurent; Sampath, Deepak; Tian, Qingping; Tsui, Vickie; Wan, Nan Chi; Wang, Shumei; Wei, Binqing; Wiesmann, Christian; Wu, Ping; Zhu, Bing Yan; Olivero, Alan

View on PubMed
Phosphorous Dysregulation Induced by MEK Small Molecule Inhibitors in the Rat Involves Blockade of FGF-23 Signaling in the Kidney. Toxicological Sciences, 5 Oct 2011, ISSN: 1096-0929.

Diaz, Dolores; Allamneni, Krishna; Tarrant, Jaqueline M; Lewin, Koh Sock C; Pai, Rama; Dhawan, Preeti; Cain, Gary R; Kozlowski, Cleopatra; Hiraragi, Hajime; La, Nghi; Hartley, Dylan P; Ding, Xiao; Dean, Brian J; Bheddah, Sheila; Dambach, Donna M

View on PubMed
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood, 2011, V118, N13, SEP 29, pp 3459-3469. ISSN: 0006-4971.

Ma, Peilin; Mali, Raghuveer Singh; Munugalavadla, Veerendra; Krishnan, Subha; Ramdas, Baskar; Sims, Emily; Martin, Holly; Ghosh, Joydeep; Li, Shuo; Chan, Rebecca J; Krystal, Gerald; Craig, Andrew W; Takemoto, Clifford; Kapur, Reuben

View on PubMed
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proceedings of the National Academy of Sciences, 26 Sep 2011, ISSN: 1091-6490.

Dompe, Nicholas; Rivers, Celina Sanchez; Li, Li; Cordes, Shaun; Schwickart, Martin; Punnoose, Elizabeth A; Amler, Lukas; Seshagiri, Somasekar; Tang, Jerry; Modrusan, Zora; Davis, David P

View on PubMed
A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis. Science Translational Medicine, 21 Sep 2011, vol. 3, no. 101, p. 101ra92, ISSN: 1946-6234, eISSN: 1946-6242.

Owczarczyk, Kasia; Lal, Preeti; Abbas, Alexander R; Wolslegel, Kristen; Holweg, Cecile T J; Dummer, Wolfgang; Kelman, Ariella; Brunetta, Paul; Lewin, Koh Nicholas; Sorani, Marco; Leong, Diane; Fielder, Paul; Yocum, David; Ho, Carole; Ortmann, Ward; Townsend, Michael J; Behrens, Timothy W

View on PubMed
Wnt Antagonists Bind through a Short Peptide to the First beta-Propeller Domain of LRP5/6. Structure, 21 Sep 2011, ISSN: 1878-4186.

Bourhis, Eric; Wang, Weiru; Tam, Christine; Hwang, Jiyoung; Zhang, Yingnan; Spittler, Didier; Huang, Oscar W; Gong, Yan; Estevez, Alberto; Zilberleyb, Inna; Rouge, Lionel; Chiu, Cecilia; Wu, Yan; Costa, Mike; Hannoush, Rami N; Franke, Yvonne; Cochran, Andrea G

View on PubMed
A secreted protein microarray platform for extracellular protein interaction discovery. Analytical Biochemistry, 21 Sep 2011, ISSN: 1096-0309.

Ramani, Sree R; Tom, Irene; Lewin, Koh Nicholas; Wranik, Bernd; Depalatis, Laura; Zhang, Jianjun; Eaton, Dan; Gonzalez, Lino C

View on PubMed
A reserve stem cell population in small intestine renders Lgr5- positive cells dispensable. Nature, 18 Sep 2011, ISSN: 1476-4687.

Tian, Hua; Biehs, Brian; Warming, Soeren; Leong, Kevin G; Rangell, Linda; Klein, Ophir D; de Sauvage, Frederic J

View on PubMed
USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma. Cell, 16 Sep 2011, vol. 146, no. 6, p. 918-30, ISSN: 1097-4172.

Williams, Samuel A; Maecker, Heather L; French, Dorothy M; Liu, Jinfeng; Gregg, Andrew; Silverstein, Leah B; Cao, Tim C; Carano, Richard A D; Dixit, Vishva M

View on PubMed
Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition. Chemical Research in Toxicology, 9 Sep 2011, ISSN: 1520-5010.

Zhang, Chenghong; Kenny, Jane R; Le, Hoa; Deese, Alan; Ford, Kevin A; Lightning, Luke K; Fan, Peter W; Driscoll, James P; Halladay, Jason S; Hop, Cornelis E C A; Khojasteh, S Cyrus

View on PubMed
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. Journal of Cell Biology, 5 Sep 2011, v194, n5, p751-64, ISSN: 1540-8140.

Sengupta, Ghosh Arundhati; Wang, Bei; Pozniak, Christine D; Chen, Mark; Watts, Ryan J; Lewcock, Joseph W

View on PubMed
A20 edits ubiquitin and autoimmune paradigms. Nature genetics, 1 August 2011, vol. 43, no. 9, p. 822-3, ISSN: 1546-1718.

Martin, Flavius; Dixit, Vishva M

View on PubMed
Lyp breakdown and autoimmunity Nature Genetics, 29 August 2011, vol. 43, no. 9, p. 821-2, ISSN: 1546-1718.

Behrens, Timothy W

View on PubMed
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium Nature Immunology, 28 Aug 2011 (epub: 28 8 2011), ISSN: 1529-2916.

Ota, Naruhisa; Wong, Kit; Valdez, Patricia A; Zheng, Yan; Crellin, Natasha K; Diehl, Lauri; Ouyang, Wenjun

View on PubMed
Regulation of interleukin-10 and interleukin-22 expression in T helper cells Current Opinion in Immunology, 20 Aug 2011, ISSN: 1879-0372.

Rutz, Sascha; Ouyang, Wenjun

View on PubMed
Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers Cancer Cell, 16 Aug 2011, vol. 20, no. 2, p. 158-72, ISSN: 1878-3686.

Wilson, Timothy R; Lee, Diana Y; Berry, Leanne; Shames, David S; Settleman, Jeff

View on PubMed
Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. Journal of Experimental Medicine, 2011, V208, 9, pp 1777-1787. ISSN: 0022-1007, eISSN: 1540-9538

Niko Föger; André Jencke; Zane Orinska; Kyeong-Hee Lee; Andrew C. Chan; Silvia Bulfone-Paus;

View on PubMed
Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield Structure, 10 Aug 2011, vol. 19, no. 8, p. 1053-63, ISSN: 1878-4186.

Dong, Ken C; Helgason, Elizabeth; Yu, Christine; Phu, Lilian; Arnott, David P; Bosanac, Ivan; Compaan, Deanne M; Huang, Oscar W; Fedorova, Anna V; Kirkpatrick, Donald S; Hymowitz, Sarah G; Dueber, Erin C

View on PubMed
Pervasive Sharing of Genetic Effects in Autoimmune Disease. PLoS Genetics, 10 AUG 2011, V7, N8, ISSN: 1553-7390.

Cotsapas, Chris; Voight, Benjamin F; Rossin, Elizabeth; Lage, Kasper; Neale, Benjamin M; Wallace, Chris; Abecasis, Goncalo R; Barrett, Jeffrey C; Behrens, Timothy; Cho, Judy; De Jager, Philip L; Elder, James T; Graham, Robert R; Gregersen, Peter; Klareskog, Lars; Siminovitch, Katherine A; van, Heel David A; Wijmenga, Cisca; Worthington, Jane; Todd, John A; Hafler, David A; Rich, Stephen S; Daly, Mark J

View on PubMed
miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer Science signaling, 16 Aug 2011, vol. 4, no. 186, p. pt5, ISSN: 1937-9145.

Stinson, Susanna; Lackner, Mark R; Adai, Alex T; Yu, Nancy; Kim, Hyo Jin; O, Brien Carol; Spoerke, Jill; Jhunjhunwala, Suchit; Boyd, Zachary; Januario, Thomas; Newman, Robert J; Yue, Peng; Bourgon, Richard; Modrusan, Zora; Stern, Howard M; Warming, Soeren; de Sauvage, Frederic J; Amler, Lukas; Yeh, Ru Fang; Dornan, David

View on PubMed
Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics PloS One, 2011 (epub: 04 Aug 2011), vol. 6, no. 8, p. e22607, ISSN: 1932-6203.

Anderson, Daniel J; Durieux, Jenni K; Song, Kyung; Alvarado, Ryan; Jackson, Peter K; Hatzivassiliou, Georgia; Ludlam, Mary J C

View on PubMed
Lebrikizumab Treatment in Adults with Asthma The New England journal of medicine, {N-Engl-J-Med}, 3 Aug 2011 (epub: 3 8 2011), ISSN: 1533-4406.

Corren, Jonathan; Lemanske, Robert F; Hanania, Nicola A; Korenblat, Phillip E; Parsey, Merdad V; Arron, Joseph R; Harris, Jeffrey M; Scheerens, Heleen; Wu, Lawren C; Su, Zheng; Mosesova, Sofia; Eisner, Mark D; Bohen, Sean P; Matthews, John G

View on PubMed
Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

Abbas, Alexander R; Jackman, Janet K; Bullens, Sherron L; Davis, Sarah M; Choy, David F; Fedorowicz, Grazyna; Tan, Martha; Truong, Bao Tran; Gloria, Meng Y; Diehl, Lauri; Miller, Lisa A; Schelegle, Edward S; Hyde, Dallas M; Clark, Hilary F; Modrusan, Zora; Arron, Joseph R; Wu, Lawren C

View on PubMed
Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody Pharmaceutical Research, {Pharm-Res}, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1573-904X.

Sreedhara, Alavattam; Cordoba, Armando; Zhu, Qing; Kwong, Jeanne; Liu, Jun

View on PubMed
On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format. Analytical Biochemistry, 2 Aug 2011, ISSN: 1096-0309.

Alvarez, Melissa; Tremintin, Guillaume; Wang, Jennifer; Eng, Marian; Kao, Yung Hsiang; Jeong, Justin; Ling, Victor T; Borisov, Oleg V

View on PubMed
Genetic Analyses of Interferon Pathway-Related Genes Reveal Multiple New Loci Associated With Systemic Lupus Erythematosus. Arthritis & Rheumatism, 2011, V63, N7, JUL, pp 2049-2057. ISSN: 0004-3591.

Ramos, Paula S; Williams, Adrienne H; Ziegler, Julie T; Comeau, Mary E; Guy, Richard T; Lessard, Christopher J; Li, He; Edberg, Jeffrey C; Zidovetzki, Raphael; Criswell, Lindsey A; Gaffney, Patrick M; Graham, Deborah Cunninghame; Graham, Robert R; Kelly, Jennifer A; Kaufman, Kenneth M; Brown, Elizabeth E; Alarcon, Graciela S; Petri, Michelle A; Reveille, John D; McGwin, Gerald; Vila, Luis M; Ramsey, Goldman Rosalind; Jacob, Chaim O; Vyse, Timothy J; Tsao, Betty P; Harley, John B; Kimberly, Robert P; Alarcon, Riquelme Marta E; Langefeld, Carl D; Moser, Kathy L

View on PubMed
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex The EMBO journal, {EMBO-J}, 19 Jul 2011 (epub: 19 7 2011), ISSN: 1460-2075.

Bentley, Matthew L; Corn, Jacob E; Dong, Ken C; Phung, Qui; Cheung, Tommy K; Cochran, Andrea G

View on PubMed
Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling PLoS ONE, {PLoS-ONE}, 2011, vol. 6, no. 7, article number: e22595, 35 refs, eISSN: 1932-6203. Publisher: Public Library of Science, 185 Berry Street, Suite 1300, San Francisco, CA 94107, USA.

Callow, Marinella G; Tran, Hoanh; Phu, Lilian; Lau, Ted; Lee, James; Sandoval, Wendy N; Liu, Peter S; Bheddah, Sheila; Tao, Janet; Lill, Jennie R; Hongo, Jo Anne; Davis, David; Kirkpatrick, Donald S; Polakis, Paul; Costa, Mike

View on PubMed
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination BLOOD, 2011, V118, N3, JUL 21, pp 598-608. ISSN: 0006-4971.

Nguyen, Xuan Hung; Lang, Philipp A; Lang, Karl S; Adam, Dieter; Fattakhova, Gulnar; Foeger, Niko; Kamal, Mohammad Azhar; Prilla, Patricia; Mathieu, Sabine; Wagner, Christina; Mak, Tak; Chan, Andrew C; Lee, Kyeong Hee

View on PubMed
Preview: A Program for Surveying Shotgun Proteomics Tandem Mass Spectrometry Data. ANALYTICAL CHEMISTRY, 2011, V83, N13, JUL 1, pp 5259-5267. ISSN: 0003-2700.

Kil, Yong J; Becker, Christopher; Sandoval, Wendy; Godberg, David; Bern, Marshall

View on PubMed
Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Drug metabolism and disposition: the biological fate of chemicals, {Drug-Metab-Dispos}, 8 Jul 2011 (epub: 8 7 2011), ISSN: 1521-009X.

Liu, Lichuan; Halladay, Jason; Shin, Young; Wong, Susan; Coraggio, Melis; La, Hank; Baumgardner, Matthew; Le, Hoa; Gopaul, Sashi; Boggs, Jason; Kuebler, Peter; Davis, John; Liao, Charlene; Lubach, Joseph; Deese, Alan; Sowell, Gregory; Currie, Kevin; Young, Wendy; Khojasteh, Cyrus; Hop, Cornelis; Wong, Harvey

View on PubMed
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. NEW ENGLAND JOURNAL OF MEDICINE, 2011, V364, N26, JUN 30, pp 2507-2516. ISSN: 0028-4793.

Chapman, PB; Hauschild, A; Robert, C; Haanen, JB; Ascierto, P; Larkin, J; Dummer, R; Garbe, C; Testori, A; Maio, M; Hogg, D; Lorigan, P; Lebbe, C; Jouary, T; Schadendorf, D; Ribas, A; O'Day, SJ; Sosman, JA; Kirkwood, JM; Eggermont, AM; Dreno, B; Nolop, K; Li, J; Nelson, B; Hou, J; Lee, RJ; Flaherty, KT; McArthur, AG; BRIM-3 Study Group

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development Blood, 2011, ISSN:

Kyle Niessen; Gu Zhang; John Brady Ridgway; Hao Chen; Ganesh Kolumam; Christian W Siebel; Minhong Yan

View on PubMed
Innate immunity: unfolding the neuro-immuno connections. Current biology : CB, {Curr-Biol}, 21 Jun 2011, vol. 21, no. 12, p. R474-6, ISSN: 1879-0445.

Tan, Man Wah

View on PubMed
Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map Analysis Analytical Chemistry, 2011, V83, N15, AUG 1, pp 5912-5919. ISSN: 0003-2700.

Yu, X Christopher; Joe, Koman; Zhang, Yu; Adriano, Andrea; Wang, Yaning; Gazzano, Santoro Helene; Keck, Rodney G; Deperalta, Galahad; Ling, Victor

View on PubMed
Innate immunity: Unfolding the neuro-immuno connections in resistance and tolerance Current Biology, 2011, ISSN:

Tan, Man-Wah

View on PubMed
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer. Science Signaling, 2011, ISSN: 1945-0877

Stinson, Susanna; Lackner, Mark R; Adai, Alex T; Yu, Nancy; Kim, Hyo-Jin; O’Brien, Carol; Spoerke, Jill; Jhunjhunwala, Suchit; Boyd, Zachary; Januario, Thomas; Newman, Robert J; Yue, Peng; Bourgon, Richard; Modrusan, Zora; Stern, Howard M; Warming, Søren; de Sauvage, Frederic J; Amler, Lukas; Yeh, Ru-Fang; Dornan, David

View on PubMed
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1. NEURON, 2011, V70, N5, JUN 9, pp 966-978. ISSN: 0896-6273.

de Almodovar, Carmen Ruiz; Fabre, Pierre J; Knevels, Ellen; Coulon, Cathy; Segura, Inmaculada; Haddick, Patrick C G; Aerts, Liesbeth; Delattin, Nicolas; Strasser, Geraldine; Oh, Won Jong; Lange, Christian; Vinckier, Stefan; Haigh, Jody; Fouquet, Coralie; Gu, Chengua; Alitalo, Kari; Castellani, Valerie; Tessier-Lavigne, Marc; Chedotal, Alain; Charron, Frederic; Carmeliet, Peter

View on PubMed
Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N21, MAY 27, pp 18969-18981. ISSN: 0021-9258.

Lobito, Adrian A; Ramani, Sree R; Tom, Irene; Bazan, J Fernando; Luis, Elizabeth; Fairbrother, Wayne J; Ouyang, Wenjun; Gonzalez, Lino C

AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3 beta (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, V286, N19, MAY 13, pp 16879-16890. ISSN: 0021-9258.

Zhang, Li; Jouret, Francois; Rinehart, Jesse; Sfakianos, Jeff; Mellman, Ira; Lifton, Richard P; Young, Lawrence H; Caplan, Michael J

View on PubMed
Rituximab's New Therapeutic Target: The Podocyte Actin Cytoskeleton. Science translational medicine, {Sci-Transl-Med}, 1 Jun 2011, vol. 3, no. 85, p. 85ps21, ISSN: 1946-6242.

Chan, Andrew C

Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation. Pharmaceutical research, {Pharm-Res}, 8 Jun 2011 (epub: 8 6 2011), ISSN: 1573-904X.

Lam, Xanthe M; Lai, William G; Chan, Edwin K; Ling, Victor; Hsu, Chung C

View on PubMed
Immunology: In command of commensals. NATURE, 2011, V474, N7349, JUN 2, pp 43-44. ISSN: 0028-0836.

van Lookeren Campagne, Menno; Dixit, Vishva M

View on PubMed
TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma PLoS ONE, 2011, ISSN: 1932-6203

Lin, K.; Taylor, J.R.; Wu, T.D.; Gutierrez, J.; Elliott, J.M.; Vernes, J.M.; Koeppen, H.; Phillips, H.S.; de Sauvage, F.J.; Meng, Y.G.

View on PubMed
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. NATURE, 2011, V474, N7352, JUN 23, pp 511-NIL_141. ISSN: 0028-0836.

Stefater, James A III; Lewkowich, Ian; Rao, Sujata; Mariggi, Giovanni; Carpenter, April C; Burr, Adam R; Fan, Jieqing; Ajima, Rieko; Molkentin, Jeffery D; Williams, Bart O; Wills-Karp, Marsha; Pollard, Jeffrey W; Yamaguchi, Terry; Ferrara, Napoleone; Gerhardt, Holger; Lang, Richard A

View on PubMed
Multiple Effects of Angiopoietin-2 Blockade on Tumors. Cancer Cell, 2011, ISSN: 1535-6108

Lewis, C.E.; Ferrara, N.

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. Blood, 2011, ISSN: 0006-4971

Gavins, F.N.E.; Russell, J.; Senchenkova, E.L.; Paula, L.D.A.; Damazo, A.S.; Esmon, C.T.; Kirchhofer, D.; Hebbel, R.P.; Granger, D.N.

High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin is Entropy-Driven in Spite of Structural Plasticity. PloS One, 2011, ISSN: 1932-6203

Bostrom, J.; Haber, L.; Koenig, P.; Kelley, R.F.; Fuh, G.

1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nature Neuroscience, 2011, ISSN: 1097-6256

Jo, J.; Whitcomb, D.J.; Olsen, K.M.; Kerrigan, T.L.; Lo, S.C.; Bru-Mercier, G.; Dickinson, B.; Scullion, S.; Sheng, M.; Collingridge, G.; Cho, K.

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production. PLoS Genetics, 2011, ISSN: 1553-7390

Chung, S.A.; Taylor, K.E.; Graham, R.R.; Nititham, J.; Lee, A.T. Ortmann, W.A.; Jacob, C.O.; Alarcón-Riquelme, M.E.; Tsao, B.P.; Harley, J.B.; Gaffney, P.M.; Moser, K.L.; Petri, M.; Demirci, F.Y.; Kamboh, M.I.; Manzi, S.; Gregersen, P.K.; Langefeld, C.D.; Behrens, T.W.; Criswell, L.A.

Toward Understanding Molecular Heterogeneity of Polysorbates by Application of Liquid Chromatography-Mass Spectrometry with Computer-Aided Data Analysis. Analytical Chemistry, 2011, ISSN: 1520-6882

Borisov, O.V.; Ji, J.A.; Wang, Y.J.; Vega, F.; Ling, V.T.

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry. Molecular Cell, 2011, ISSN: 1097-4164

Huang, X.; Summers, M.K.; Pham, V.; Lill, J.R.; Liu, J.; Lee, G.; Kirkpatrick, D.S.; Jackson, P.K.; Fang, G.; Dixit, V.M.

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons Proceedings Of The National Academy Of Sciences, 2011, ISSN: 0027-8424

Parikh, P.; Hao, Y.; Hosseinkhani, M.; Patil, S.B.; Huntley, G.W.; Tessier-Lavigne, M.; Zou, H.

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells Proceedings of the National Academy of Sciences, 2011, ISSN: 1091-6490

Eastham Anderson, Jeff; Dunlap, Debra; Alicke, Bruno; Nannini, Michelle; Gould, Stephen; Yauch, Robert; Modrusan, Zora; Dupree, Kelly; Darbonne, Walter; de Sauvage, Frederic

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. BLOOD, 2011, V117, N21, MAY 26, pp 5652-5662. ISSN: 0006-4971.

Yao, David; Huang, Yuanshuai; Huang, Xiaoran; Wang, Weihuan; Yan, Quanjian; Wei, Lebing; Xin, Wei; Gerson, Stanton; Stanley, Pamela; Lowe, John B; Zhou, Lan

View on PubMed
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target. Science Translational Medicine, 2011, ISSN: 1946-6234

Yu, Y.J.; Zhang, Y.; Kenrick, M.; Hoyte, K.; Luk, W.; Lu, Y.; Atwal, J.; Elliott, J.M.; Prabhu, S.; Watts, R.J.; Dennis, M.S.

View on PubMed
A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo Science Translational Medicine, 2011, ISSN: 1946-6234

Atwal, J.K.; Chen, Y.; Chiu, C.; Mortensen, D.L.; Meilandt, W.J.; Liu, Y.; Heise, C.E.; Hoyte, K.; Luk, W.; Lu, Y.; Peng, K.; Wu, P.; Rouge, L.; Zhang, Y.; Lazarus, R.A.; Scearce-Levie, K.; Wang, W.; Wu, Y.; Tessier-Lavigne, M.; Watts, R.J.

View on PubMed
A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry. Drug Metabolism and Disposition, 2011, ISSN: 1521-009X

Graham, R.A.; Lum, B.L.; Morrison, G.; Chang, I.; Jorga, K.; Dean, B.J.;Shin, Y.; Yue, Q.; Mulder, T.; Malhi, V.; Xie, M.; Low, J.; Hop, C.E.

View on PubMed
COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature, 2011, ISSN: 0028-0836

Vitari, A.C.; Leong, K.G.; Newton, K.; Yee, C.; O'Rourke, K.; Liu, J.; Phu, L.; Vij, R.; Ferrando, R.; Couto, S.S.; Mohan, S.; Pandita, A.; Hongo, J.A.; Arnott, D.; Wertz, I.E.; Gao, W.Q.; French, D.M.; Dixit, V.M.

View on PubMed
Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Cell, 2011, ISSN: 1097-4172

Sang, L.; Miller, J.J.; Corbit, K.C.; Giles, R.H.; Brauer, M.J.; Otto, E.A.; Baye, L.M.; Wen, X.; Scales, S.J.; Kwong, M.; Huntzicker, E.G.; Sfakianos, M.K.; Sandoval, W.; Bazan, J.F.; Kulkarni, P.; Garcia-Gonzalo, F.R.; Seol, A.D.; O'Toole, J.F.; Held, S.; Reutter, H.M.; Lane, W.S.; Rafiq, M.A.; Noor, A.; Ansar, M.; Devi, A.R.; Sheffield, V.C.; Slusarski, D.C.; Vincent, J.B.; Doherty, D.A.; Hilde

View on PubMed
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Journal of Clinical Investigation, 2011, ISSN: 0021-9738

Sos, B.C.; Harris, C.; Nordstrom, S.M.; Tran, J.L.; Balazs, M.; Caplazi, P.; Febbraio, M.; Applegate, M.A.B.; Wagner, K.U.; Weiss, E.J.

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. Journal of Cell Biology, 2011, ISSN: 0021-9525

Francis, S.S.; Sfakianos, J.; Lo, B.; Mellman, I.

An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia. Blood, 2011, ISSN: 0006-4971

Danese, M.D.; Griffiths, R.I.; Gleeson, M.; Satram-Hoang, S.; Knopf, K.; Joseph, M.; Reyes, C.

Slit2 Activity in the Migration of Guidepost Neurons Shapes Thalamic Projections during Development and Evolution. Neuron, 2011, ISSN: 0896-6273

Bielle, F.; Marcos-Mondejar, P.; Keita, M.; Mailhes, C.; Verney, C.; Ba-Charvet, K.M.; Tessier-Lavigne, M.; Lopez-Bendito, G.; Garel, S.

Do cilia put brakes on the cell cycle? Nature Cell Biology, 2011, ISSN: 1476-4679

Jackson, P.K.

Randomized Phase II Study of Bevacizumab in Combination With Chemotherapy in Previously Untreated Extensive-Stage Small-Cell Lung Cancer: Results From the SALUTE Trial. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Spigel, D.R.; Townley, P.M.; Waterhouse, D.M.; Fang, L.; Adiguzel, I.; Huang, J.E.; Karlin, D.A.; Faoro, L.; Scappaticci, F.A.; Socinski, M.A.

View on PubMed
Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine. Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Cohen, F.; Bergeron, P.; Blackwood, E.; Bowman, K.K.; Chen, H.; DiPasquale, A.G.; Epler, J.A.; Koehler, M.F.T.; Lau, K.; Lewis, C.; Liu, L.; Ly, C.Q.; Malek, S.; Nonomiya, J.; Ortwine, D.F.; Pei, Z.; Robarge, K.D.; Sideris, S.; Trinh, L.; Truong, T.; Wu, J.; Zhao, X.; Lyssikatos, J.P.

View on PubMed
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences, 2011, ISSN: 1091-6490

Ong, C.C.; Jubb, A.M.; Haverty, P.M.; Zhou, W.; Tran, V.; Truong, T.; Turley, H.; O'Brien, T.; Vucic, D.; Harris, A.L.; Belvin, M.; Friedman, L.S.; Blackwood, E.M.; Koeppen, H.; Hoeflich, K.P.

View on PubMed
Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Sleebs, B.E.; Czabotar, P.E.; Fairbrother, W.J.; Fairlie, W.D.; Flygare, J.A.; Huang, D.C.S.; Kersten, W.J.A.; Koehler, M.F.T.; Lessene, G.; Lowes, K.; Parisot, J.P.; Smith, B.J.; Smith, M.L.; Souers, A.J.; Street, I.P.; Yang, H.; Baell, J.B.

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells. Journal of Medicinal Chemistry, 2011, ISSN: 0022-2623

Stanford, S.M.; Krishnamurthy, D.; Falk, M.D.; Messina, R.; Debnath, B.; Li, S.; Liu, T.; Kazemi, R.; Dahl, R.; He, Y.; Yu, X.; Chan, A.C.; Zhang, Z.Y.; Barrios, A.M.; Woods, V.L.; Neamati, N.; Bottini, N.

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 2011, ISSN: 1535-6108

Sawey, E.T.; Chanrion, M.; Cai, C.; Wu, G.; Zhang, J.; Zender, L.; Zhao, A.; Busutti, R.W.; Yee, H.; Stein, L.; French, D.M.; Finn, R.S.; Lowe, S.W.; Powers, S.

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2011, ISSN: 0022-1759

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.L.; Meng, Y.G.

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies. PHARMACEUTICAL RESEARCH, 2011, V28, N7, JUL, pp 1750-1764. ISSN: 0724-8741.

Yadav, Sandeep; Sreedhara, Alavattam; Kanai, Sonoko; Liu, Jun; Lien, Samantha; Lowman, Henry; Kalonia, Devendra S; Shire, Steven J

View on PubMed
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-alpha Feedforward Signaling Cell, 2011, ISSN: 1097-4172

Biton, Sharon; Ashkenazi, Avi

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime. Analytical Biochemistry, 2011, ISSN: 0003-2697

Yadav, S.; Scherer, T.M.; Shire, S.J.; Kalonia, D.S.

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways. PloS One, 2011, ISSN: 1932-6203

Wu, A.L.; Coulter, S.; Liddle, C.; Wong, A.; Eastham-Anderson, J.; French, D.M.; Peterson, A.S.; Sonoda, J.

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow. PloS One, 2011, ISSN: 1932-6203

Boswell, C.A.; Ferl, G.Z.; Mundo, E.E.; Bumbaca, D.; Schweiger, M.G.; Theil, F.P.; Fielder, P.J.; Khawli, L.A.

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449). Journal of Medicinal Chemistry, 2011, ISSN: 1520-4804

Giannetti, Anthony; Wong, Harvey; Dijkgraaf, Gerrit; Dueber, Erin; Bravo, Brandon; Gould, Stephen; Plise, Emile; Lum, Bert; Malhi, Vikram; Graham, Richard; Ortwine, Daniel

View on PubMed
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer. Journal of Clinical Oncology, 2011, ISSN: 1527-7755

Robert, N.J.; Dieras, V.; Glaspy, J.; Brufsky, A.M.; Bondarenko, I.; Lipatov, O.N.; Perez, E.A.; Yardley, D.A.; Chan, S.Y.T.; Zhou, X.; Phan, S.C.; O'Shaughnessy, J.

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration. Neuron, 2011, ISSN: 0896-6273

Wang, Y.; Li, G.; Stanco, A.; Long, J.E.; Crawford, D.; Potter, G.B.; Pleasure, S.J.; Behrens, T.; Rubenstein, J.L.R.

Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies. Journal of Immunological Methods, 2011, ISSN: 0022-1759

Ren, D.; Darlucio, M.R.; Chou, J.H.

CD40 Pathway Activation Status Predicts Response to CD40 Therapy in Diffuse Large B Cell Lymphoma. Science Translational Medicine, 2011, ISSN: 1946-6242

Burington, B.; Yue, P.; Shi, X.; Advani, R.; Lau, J.T.; Tan, J.; Stinson, S.; Stinson, J.; Januario, T.; de Vos, S.; Ansell, S.; Forero-Torres, A.; Fedorowicz, G.; Yang, T.T.C.; Elkins, K.; Du, C.; Mohan, S.; Yu, N.; Modrusan, Z.; Seshagiri, S.; Yu, S.F.; Pandita, A.; Koeppen, H.; French, D.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.; Dornan, D.

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes PLoS Genetics, 2011, ISSN: 1553-7390

Taylor, K.E.; Chung, S.A.; Graham, R.R.; Ortmann, W.A.; Lee, A.T.; Langefeld, C.D.; Jacob, C.O.; Kamboh, M.I.; Alarcón;-Riquelme, M.E., Tsao, B.P.; Moser, K.L.; Gaffney, P.M.; Harley, J.B.; Petri, M.; Manzi, S.; Gregersen, P.K.; Behrens, T.W.; Criswell, L.A.

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 2011, ISSN: 0002-9297

Lanktree, M.B.; Keating, B.J.; et al. (Bhangale, T.)

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells. Blood, 2011, ISSN: 0006-4971

Favre, D.; Stoddart, C.A.; Emu, B.;Hoh, R.; Martin, J.N.; Hecht, F.M.; Deeks, S.G.; McCune, J.M.

Sensitivity to Anti-Tubulin Chemotherapeutics is regulated by Mcl-1 and FBW7 Nature, 2011, ISSN: 0028-0836

Wertz, Ingrid; Kusam, Saritha; Lam, Cynthia; Okamoto, T.; Sandoval, Wendy; Anderson, D.J.; Helgason, E.; Ernst, James; Eby, M.; Liu, Jinfeng; Belmont, L.D.; Kaminker, Joshua; O'Rourke, Karen; Pujara, Kanan; Kohli, Pawan; Johnson, Adam; Chiu, M.L.; Lill, Jennie; Jackson, P.K.; Fairbrother, Wayne; Seshagiri, Somasekar; Ludlam, M.J.C.; Leong, K.G.; Dueber, E.C.; Maecker, H.; Huang, D.C.S.; Dixit, Vishva

View on PubMed
Benzo[a]pyrene Increases the Nrf2 Content by Downregulating the Keap1 Message. Toxicological Sciences, 2010, ISSN: 1096-6080

Nguyen, P.M.; Park, M.S.; Chow, M.; Chang, J.H.; Wrischnik, L.; Chan, W.K.

Pregnancy outcomes after maternal exposure to rituximab. Blood, 2011, ISSN: 0006-4971

Chakravarty, E.F.; Murray, E.R.; Kelman, A.; Farmer, P.

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening. Drug Metabolism and Disposition, {Drug-Metab-Dispos}, June 2011, vol. 39, no. 6, p. 952-965, 22 refs, CODEN: DMDSA, eISSN: 1521-009X, ISSN: 0090-9556. Publisher: American Society for Pharmacology and Experimental Therapy, 9650 Rockville Pike, Bethesda, MD 20814, USA.

Yue, Qin; Chen, Yung Hsiang; Mulder, Teresa; Deese, Alan; Takahashi, Ryan; Rudewicz, Patrick J; Reynolds, Mark; Solon, Eric; Hop, Cornelis ECA; Wong, Harvey; Khojasteh, S Cyrus

View on PubMed
Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes p450. Drug Metabolism and Disposition, 2011, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PLoS One, 2011, ISSN: 1932-6203

Lee, G.; Origanti, S.; White, L.; Sun, J.; Stappenbeck, T.; Piwnica-Worms, H.

TRAPing a new gene for autoimmunity. Nature Genetics, 2011, ISSN: 1546-1718

Behrens, T.; Graham, R.

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells. Cancer Cell, 2011, ISSN: 1535-6108

Wilson, N.; Yang, B.; Yang, A.; Loeser, S.; Marsters, S.; Lawrence, D.; Li, Y.; Pitti, R.; Totpal, K.; Yee, S.; Ross, S.; Vernes, J.; Lu, Y.; Adams, C.; Offringa, R.; Kelley, B.; Hymowitz, S.; Daniel, D.; Meng, G.; Ashkenazi, A.

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease. Neuron, 2011, ISSN: 1097-4199

Bingol, B.; Sheng, M.

Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary LC-MS. Analytical Biochemistry, 2011, ISSN: 1096-0309

Xu, K.; Liu, L.; Saad, O.; Baudys, J.; Williams, L.; Leipold, D.; Shen, B.; Raab, H.; Junutula, J.; Kim, A.; Kaur, S.

Glucocorticoid-induced Leucine Zipper 1 Stimulates the Epithelial Sodium Channel by Regulating Serum- and Glucocorticoid-induced Kinase 1 Stability and Subcellular Localization. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, ISSN: 0021-9258

Soundararajan, R.; Wang, J.; Melters, D.; Pearce, D.

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Batten, M.; Ramamoorthi, N.; Kljavin, N.; Ma, C.; Cox, J.; Dengler, H.; Danilenko, D.; Caplazi, P.; Wong, M.; Fulcher, D.; Cook, M.; King, C.; Tangye, S.; de Sauvage, F.; Ghilardi, N.

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell, 2011, ISSN: 1878-1551

Koch, A.; Mathivet, T.; Larrivee, B.; Tong, R.; Kowalski, J.; Pibouin-Fragner, L.; Bouvree, K.; Stawicki, S.; Nicholes, K.; Rathore, N.; Scales, S.; Luis, E.; Del, T.; Freitas, C.; Breant, C.; Michaud, A.; Corvol, P.; Thomas, J.; Wu, Y.; Peale, F.; Watts, R.; Tessier-Lavigne, M.; Bagri, A.; Eichmann, A.

View on PubMed
UNCovering the Molecular Machinery of Dependence Receptor Signaling. Molecular Cell, 2010, ISSN: 1097-4164

Bagri, A.; Ashkenazi, A.

Translational Pharmacokinetics and Pharmacodynamics of an FcRn-Variant Anti-CD4 Monoclonal Antibody From Preclinical Model to Phase I Study. Clinical Pharmacology and Therapeutics, 2010, ISSN: 1532-6535

Zheng, Y.; Scheerens, H.; Davis, J.C.; Deng, R.; Fischer, S.K.; Woods, C.; Fielder, P.J.; Stefanich, E.G.

Identification of IgG(1) variants with increased affinity to Fcγ RIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.; Meng, Y.G.

Utility of inter-system extrapolation factors (ISEFs) in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochrome P450s. Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Chen, Y.; Liu, L.; Nguyen, K.; Fretland, A.J.

NFKBIA Deletion in Glioblastomas. New England Journal of Medicine, 2010, ISSN: 1533-4406

Bredel, M.; Scholtens, D.M.; Yadav, A.K.; Alvarez, A.A.; Renfrow, J.J,; Chandler, J.P.; Yu, I.L.; Carro, M.S.; Dai, F.; Tagge, M.J.; Ferrarese, R.; Bredel, C.; Phillips, H.S.; Lukac, P.J.; Robe, P.A.; Weyerbrock, A.; Vogel, H.; Dubner, S.; Mobley, B.; He, X.; Scheck, A.C.; Sikic, B.I.; Aldape, K.D.; Chakravarti, A.; Harsh, G.R.

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer After Prior HER2-Directed Therapy. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Burris, H.A.; Rugo, H.S.; Vukelja, S.J.; Vogel, C.L.; Borson, R.A.; Limentani, S.; Tan, C.E.; Krop, I.E.; Michaelson, R.A.; Girish, S.; Amler, L.; Zheng, M.; Chu, Y.W.; Klencke, B.; O'Shaughnessy, J.A.

IL-27 promotes T cell-dependent colitis through multiple mechanisms. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Cox, J.H.; Kljavin, N.M.; Ramamoorthi, N.; Diehl, L.; Batten, M.; Ghilardi, N.

Identification of Isomerization and Racemization of Aspartate in the Asp-Asp Motifs of a Therapeutic Protein. Analytical Biochemistry, 2010, ISSN: 1096-0309

Zhang, J.; Yip, H.; Katta, V.

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets. Immunity, 2010, ISSN: 1074-7613

Palucka, K.; Banchereau, J.; Mellman, I.

Reply to Talloen et al.: Independent filtering is a generic approach that needs domain specific adaptation. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Bourgon, R.; Gentleman, R.; Huber, W.

Identification and functional analysis of endothelial tip cell-enriched genes. Blood, 2010, ISSN: 0006-4971

del Toro, R.; Prahst, C.; Mathivet, T.; Siegfried, G.; Kaminker, J.S.; Larrivee, B,; Breant, C.; Duarte, A.; Takakura, N.; Fukamizu, A.; Penninger, J.; Eichmann, A.

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO Journal, 2010, ISSN: 1460-2075

Dynek, J.N.; Goncharov, T.; Dueber, E.C.; Fedorova, A.V.; Izrael-Tomasevic, A.; Phu, L.; Helgason, E.; Fairbrother, W.J.; Deshayes, K.; Kirkpatrick, D.S.; Vucic, D.

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling. Molecular Cell, 2010, ISSN: 1097-2765

Bosanac, I.; Wertz, I.E.; Pan, B.; Yu, C.; Kusam, S.; Lam, C.; Phu, L.; Phung, Q.; Maurer, B.; Arnott, D.; Kirkpatrick, D.S.; Dixit, V.M.; Hymowitz, S.G.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis Nature Chemical Biology, 2010, ISSN: 1552-4469

Di Paolo, Julie; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai; Bravo, Brandon; Carano, Richard; Darrow, James; Davies, Douglas; DeForge, Laura; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven; Giannetti, Anthony; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah; Jones, Randall; Kropf, Jeffrey; Lee, Wyne; Maciejewski, Patricia; Mitchell, Scott; Rong, Hong; Staker, Bart; Whitney, Andrew; Yeh, Sherry; Young, Wendy; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin

View on PubMed
Unleashing cell death: the Fas-FADD complex. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Hymowitz, S.G.; Dixit, V.M.

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development, 2010, ISSN: 0950-1991

Seidel, K.; Ahn, C.; Lyons, D.; Nee, A.; Ting, K.; Brownell, I.; Cao, T.; Carano, R.; Curran, T.; Schober, M.; Fuchs, E.; Joyner, A.; Martin, G.; de Sauvage, F.; Klein, O.

Regulation of Cytokine Secretion in Human CD127(+) LTi-like Innate Lymphoid Cells by Toll-like Receptor 2. Immunity, 2010, ISSN: 1074-7613

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Satoh, T.N.; DiSanto, J.P.; Spits, H.

Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood, 2010, ISSN: 0006-4971

Jo, S.H.; Schatz, J.H.; Acquaviva, J.; Singh, H.; Ren, R.

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes. Developmental Cell, 2010, ISSN: 1534-5807

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; Baron, R.

Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying. Pharmaceutical Research, 2010, ISSN: 0724-8741

Sundaramurthi, P.; Patapoff, T.W.; Suryanarayanan, R.

Clinical Experience With Hedgehog Pathway Inhibitors. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Low, J.A.; de Sauvage, F.J.

Electrostatic Docking of a Supramolecular Host-Guest Assembly to Cytochrome c Probed by Bidirectional Photoinduced Electron Transfer. Journal of the American Chemical Society, 2010, ISSN: 1520-5126

Jankowska, K.I.; Pagba, C.V.; Piatnitski Chekler, E.L.; Deshayes, K.; Piotrowiak, P.

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genetics, 2010, ISSN: 1061-4036

Otto, E.; Hurd, T.; Airik, R.; Chaki, M.; Zhou, W.; Stoetzel, C.; Patil, S.; Levy, S.; Ghosh, A.; Murga- Zamalloa, C.; van Reeuwijk, J.; Letteboer, S.; Sang, L.; Giles, R.; Liu, Q.; Coene, K.; Estrada-Cuzcano, A.; Collin, R.; McLaughlin, H.; Held, S.; Kasanuki, J.; Ramaswami, G.; Conte, J.; Lopez, I.; Washburn, J.; MacDonald, J.; Hu, J.; Yamashita, Y.; Maher, E.; Guay-Woodford, L.; Neumann, H.; O

Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Khojasteh, S.C.; Oishi, S.; Nelson, S.

Developmental Immunotoxicology Assessment of Rituximab in Cynomolgus Monkeys. Toxicological Sciences, 2010, ISSN: 1096-0929

Vaidyanathan, A.; McKeever, K.; Anand, B.; Eppler, S.; Weinbauer, G.; Beyer, J.

Vegf regulates embryonic erythroid development through Gata1 modulation. Blood, 2010, ISSN: 0006-4971

Drogat, B.; Kalucka, J.; Gutierrez, L.; Hammad, H.; Goossens, S.; Ghahremani, M.F.; Bartunkova, S.; Haigh, K.; Deswarte, K.; Nyabi, O.; Naessens, M.; Ferrara, N.; Klingmueller, U.; Lambrecht, B.; Nagy, A.; Philipsen, S.; Haigh, J.

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood, 2010, ISSN: 0006-4971

Moll, M.; Andersson, S.; Smed-Soerensen, A.; Sandberg, J.

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nature Medicine, 2010, ISSN: 1546-170X

Ferrara, N.

Optimizing Collection of Adverse Event Data in Cancer Clinical Trials Supporting Supplemental Indications. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Kaiser, L.; Melemed, A.; Preston, A.; Chaudri, R.; Hilary, A.; Niedzwiecki, D.; Fyfe, G.; Gough, J.; Bushnell, W.; Stephens, C.; Mace, M.K.; Abrams, J.; Schilsky, R.

Even Neurons Are Excited by Th17 Cells. Immunity, 2010, ISSN: 1097-4180

Egen, J.; Ouyang, W.

Cancer: miRNA Addiction - Depending On Life's Little Things. Current Biology, 2010, ISSN: 1879-0445

Dornan, D.; Settleman, J.

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Zhihua, J.Q.; Ying, Y.; Fox, M.; Peng, K.; Lewin-Koh, S.-C.; Coleman, D.; Good, J.; Lowe, J.; Rahman, A.; Yang, J.; Jiang, J.; Quarmby, V.; Song, A.

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Landgraf, K.E.; Santell, L.; Billeci, K.L.; Quan, C.; Young, J.C.; Maun, H.R.; Kirchhofer, D.; Lazarus, R.A.

View on PubMed
Molecular Biomarker Analyses Using Circulating Tumor Cells PLoS ONE, 2010, ISSN: 1932-6203

Punnoose, E.; Atwal, S.; Spoerke, J.; Savage, H.; Pandita, A.; Yeh, R.-F.; Pirzkall, A.; Fine, B.; Amler, L.; Chen, D.; Lackner, M.

Evaluation of Heterophilic Antibody Blocking Agents in Reducing False Positive Interference in Immunoassays for IL-17AA, IL-17FF, and IL-17AF. Journal of Immunological Methods, 2010, ISSN: 1872-7905

Deforge, L.; Loyet, K.; Delarosa, D.; Chinn, J.; Zamanian, F.; Chuntharapai, A.; Lee, J.; Hass, P.; Wei, N.; Townsend, M.; Wang, J.; Wong, W.L.

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation. Current Opinion in Cell Biology, 2010, ISSN: 1879-0410

Yang, A.; Wilson, N.; Ashkenazi, A.

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies PloS ONE, 2010, ISSN: 1932-6203

Gong, Y.; Bourhis, E.; Chiu, C.; Stawicki, S.; DeAlmeida, V.; Liu, B.; Phamluong, K.; Cao, T.; Carano, R.; Ernst, J.; Solloway, M.; Rubinfeld, B.; Hannoush, R.; Wu, Y.; Polakis, P.; Costa, M.

View on PubMed
Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer Science Translational Medicine, 2010, ISSN: 1946-6242

Wallin, J.; Guan, J.; Prior, W.-W.; Edgar, K.; Kassees, R.; Sampath, D.; Belvin, M.; Friedman, L.

View on PubMed
Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression. Neuron, 2010, ISSN: 0896-6273

Kuwako, K.; Kakumoto, K.; Imai, T.; Igarashi, M.; Hamakubo, T.; Sakakibara, S.; Tessier-Lavigne, M.; Okano, H.J.; Okano, H.

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

He, Y.; Wortmann, A.; Burke, L.; Reid, J.; Adams, M.; Abdul-Jabbar, I.; Quigley, J.; Leduc, R.; Kirchhofer, D.; Hooper, J.

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue. Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Fiorillo, E.; Orru, V.; Stanford, S.; Liu, Y.; Salek, M.; Rapini, N.; Schenone, A.; Saccucci, P.; Delogu, L.; Angelini, F.; Bitti, M.L.M.; Schmedt, C.; Chan, A.C.; Acuto, O.; Bottini, N.

Double TIP-ping. Science, 2010, ISSN: 1095-9203

Singh, H.; Demarco, I.

Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations. PLoS ONE, 2010, ISSN: 1932-6203

McCurley, N.; Mellman, I.

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature. PLoS ONE, 2010, ISSN: 1932-6203

Scott, A.; Powner, M.; Gandhi, P.; Clarkin, C.; Gutmann, D.; Johnson, R.; Ferrara, N.; Fruttiger, M.

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. Journal of Experimental Medicine, 2010, ISSN: 0022-1007

Broz, P.; Newton, K.;Lamkanfi, M.; Mariathasan, S.; Dixit, V.; Monack, D.

New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain. Neuron, 2010, ISSN: 0896-6273

Kaneko, N.; Marin, O.; Koike, M.; Hirota, Y.; Uchiyama, Y.; Wu, J.; Lu, Q.; Tessier-Lavigne, M.; Alvarez-Buylla, A.; Okano, H.; Rubenstein, J.; Sawamoto, K.

Manipulation of Host Cell Death Pathways during Microbial Infections. Cell Host & Microbe, 2010, ISSN: 1931-3128

Lamkanfi, M.; Dixit, V.

β-catenin balances immunity. Science, 2010, ISSN: 1095-9203

Mellman, I.; Clausen, B.

Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood, 2010, ISSN: 1528-0020

Dornan, D.; Spleiss, O.; Yeh, R.; Duchateau-Nguyen, G.; Dufour, A.; Zhi, J.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 2010, ISSN: 1476-4687

Kan, Z.; Jaiswal, B.; Stinson, J.; Janakiraman, V.; Bhatt, D.; Stern, H.; Yue, P.; Haverty, P.; Bourgon, R.; Zheng, J.; Moorhead, M.; Chaudhuri, S.; Tomsho, L.; Peters, B.; Pujara, K.; Cordes, S.; Davis, D.; Carlton, V.; Yuan, W.; Li, L.; Wang, W.; Eigenbrot, C.; Kaminker, J.; Eberhard, D.; Waring, P.; Schuster, S.; Modrusan, Z.; Zhang, Z.; Stokoe, D.; de Sauvage, F.; Faham, M.; Seshagiri, S.

Structural basis for high-affinity HER2 receptor binding by an engineered protein. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Eigenbrot, C.; Ultsch, M.; Dubnovitsky, A.; Abrahmsen, L.; Haerd, T.

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nature Genetics, 2010, ISSN: 1546-1718

Ferreira, R.; Pan-Hammarstroem, Q.; Graham, R.; Gateva, V.; Fontan, G.; Lee, A.; Ortmann, W.; Urcelay, E.; Fernandez-Arquero, M.; Nunez, C.; Jorgensen, G.; Ludviksson, B.; Koskinen, S.; Haimila, K.; Clark, H.; Klareskog, L.; Gregersen, P.; Behrens, T.; Hammarstroem, L.

Long live science! Long live the hedgehog! (Vive la science! Vive le herisson!) EMBO Reports, 2010, ISSN: 1469-221X

Reiter, J.; de Sauvage, F.

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nature Immunology, 2010, ISSN: 1529-2908

Hodson, D.; Janas, M.; Galloway, A.; Bell, S.; Andrews, S.; Li, C.; Pannell, R.; Siebel, C.; Mac Donald, H.R.; De Keersmaecker, K.; Ferrando, A.; Grutz, G.; Turner, M.

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody. Molecular Cell, 2010, ISSN: 1097-4164

Matsumoto, M.; Wickliffe, K.; Dong, K.; Yu, C.; Bosanac, I.; Bustos, D.; Phu, L.; Kirkpatrick, D.; Hymowitz, S.; Rape, M.; Kelley, R.; Dixit, V.

Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature Biotechnology, 2010, ISSN: 1087-0156

Domann, P.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusuess, C.; Perrett, D.; Quaglia, M.; Rapp, E.; Smallshaw, L.; Smith, N.; Smyth, W.F.; Taylor, C.

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. New England Journal of Medicine, 2010, ISSN: 0028-4793

Stone, J.; Merkel, P.; Spiera, R.; Seo, P.; Langford, Carol, A.; Hoffman, G.; Kallenberg, C.; St. Clair, E.W.; Turkiewicz, A.; Tchao, N.; Webber, L.; Ding, L.; Sejismundo, L.; Mieras, K.; Weitzenkamp, D.; Ikle, D.; Seyfert-Margolis, V.; Mueller, M.; Brunetta, P.; Allen, N.; Fervenza, F.; Geetha, D.; Keogh, K.; Kissin, E.; Monach, P.; Peikert, T.; Stegeman, C.; Ytterberg, S.; Specks, U.

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

Cao, S.; Yaqoob, U.; Das, A.; Shergill, U.; Jagavelu, K.; Huebert, R.; Routray, C.; Abdelmoneim, S.; Vasdev, M.; Leof, E.; Charlton, M.; Watts, R.; Mukhopadhyay, D.; Shah, V.

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature, 2010, ISSN: 0028-0836

Surolia, I.; Pirnie, S.; Chellappa, V.; Taylor, K.; Cariappa, A.; Moya, J.; Liu, H.; Bell, D.; Driscoll, D.; Diederichs, S.; Haider, K.; Netravali, I.; Le, S.; Elia, R.; Dow, E.; Lee, A.; Freudenberg, J.; De Jager, P.; Chretien, Y.; Varki, A.; MacDonald, M.; Gillis, T.; Behrens, T.; Bloch, D.; Collier, D.; Korzenik, J.; Podolsky, D.; Hafler, D.; Murali, M.; Sands, B.; Stone, J.; Gregersen, P.; Pi

The Tripartite Motif Protein MADD-2 Functions with the Receptor UNC-40 (DCC) in Netrin-Mediated Axon Attraction and Branching. Developmental Cell, 2010, ISSN: 1534-5807

Hao, J.; Adler, C.; Mebane, L.; Gertler, F.; Bargmann, C.; Tessier-Lavigne, M.

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia Cell, 2010, ISSN: 0092-8674

Jin, H.; White, S.R.; Shida, T.; Schulz, S.; Aguiar, M.; Gygi, S.P.; Bazan, J.F.; Nachury, M.V.

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nature Immunology, 2010, ISSN: 1529-2908

Takamatsu, H.; Takegahara, N.; Nakagawa, Y.; Tomura, M.; Taniguchi, M.; Friedel, R.; Rayburn, H.; Tessier-Lavigne, M.; Yoshida, Y.; Okuno, T.; Mizui, M.; Kang, S.; Nojima, S.; Tsujimura, T.; Nakatsuji, Y.; Katayama, I.; Toyofuku, T.; Kikutani, H.; Kumanogoh, A.

Leachables from Saline-Containing IV Bags Can Alter Therapeutic Protein Properties. Pharmaceutical Research, 2010, ISSN: 1573-904X

Chang, J.; Xiao, N.; Zhu, M.; Zhang, J.; Hoff, E.; Russell, S.; Katta, V.; Shire, S.

Role of Myeloid and Other Stromal Cell Types in Tumor Angiogenesis. Blood, 2009, ISSN: 0006-4971

Ferrara-Napoleone.;

FcRL5 as a Target of Antibody-Drug Conjugates for the Treatment of Multiple Myeloma. Blood, 2009, ISSN: 0006-4971

Polson, A.G.; Zheng, B.; Elkins, K.; Lau, J.; Go, M.A.; Scales, S.J.; Yu, S.F.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

FC-Gamma Receptor (FCGR) 2A and 3A Polymorphisms Do Not Influence the Outcome of Relapsed or Refractory CLL Patients Treated with Rituximab, Fludarabine, and Cyclophosphamide (R-FC) or Fludarabine, and Cyclophosphamide (FC) Alone. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Spleiss, O.; Yeh, R.F.; Duchateau-Nguyen, G.; Robak, T.; Moiseev, S.I.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Rossiev, V.A.; Bence-Bruckler, I.; Geisler, C.H.; Montillo, M.; Wenger, M.K.; Weisser, M.

The PI3K Inhibitor GDC-0941 Induces Growth Arrest and Apoptosis of Acute Myeloid Leukemia Cells. Blood, 2009, ISSN: 0006-4971

Sun-Laura; Berry-Leanne, Du-Changchun, Ma-Xiaoju-Max, Shi-Lily, Medeiros-Bruno-C, Ebens-Allen-J.;

CD40 Pathway Activation Status Predicts Response to CD40 Targeted Therapy in Diffuse Large b-Cell Lymphoma. Blood, 2009, ISSN: 0006-4971

Dornan, D.; Burington, B.; Yue, P.; Shi, X.; Advani, R.; Yu, N.; Lau, J.T.; Yu, S.F.; De Vos, S.; Ansell, S.M.; Forero-Torres, A.; Modrusan, Z.; Koeppen, H.; Yang, T.; Du, C.; Elkins, K.; Polson, A.G.; Offringa, R.; Whiting, N.; Ebens, A.J.

Higher Doses of Rituximab May Be Required for Patients with CLL as Compared to NHL Based On Population Pharmacokinetic (PK) Modeling. Blood, 2009, ISSN: 0006-4971

Li, J.; Zhi, J.; Wenger, M.K.; Valente, N.; Visich, J.

The PI3K Inhibitor GDC-0941 Synergizes with Standard of Care Therapies to Induce Growth Inhibition and Apoptosis of Multiple Myeloma Cells. Blood, 2009, ISSN: 0006-4971

Munugalavadla, V.; Berry, L.; Du, C.; Mariathasan, S.; Slaga, D.; Sun, L.; Chesi, M.; Bergsagel, P.L.; Ebens, A.J.

O-Fucose Modulates Notch-Controlled Blood Lineage Commitment. American Journal of Pathology, 2010, ISSN: 0002-9440

Yan, Q.; Yao, D.; Wei, L.; Huang, Y.; Myers, J.; Zhang, L.; Xin, W.; Shim, J.; Man, Y.; Petryniak, B.; Gerson, S.; Lowe, J.; Zhou, L.

A mouse knockout library for secreted and transmembrane proteins. Nature Biotechnology, 2010, ISSN: 1546-1696

Tang, T.; Li, L.; Tang, J.; Li, Y.; Lin, W.Y.; Martin, F.; Grant, D.; Solloway, M.; Parker, L.; Ye, W.; Forrest, W.; Ghilardi, N.; Oravecz, T.; Platt, K.; Rice, D.; Hansen, G.; Abuin, A.; Eberhart, D.; Godowski, P.; Holt, K.; Peterson, A.; Zambrowicz, B.; de Sauvage, F.

Caspase-3 Activation via Mitochondria is Required for Long-Term Depression and AMPA Receptor Internalization. Cell, 2010, ISSN: 0092-8674

Li, Z.; Jo, J.; Jia, J.M.; Lo, S.C.; Whitcomb, D.J.; Jiao, S.; Cho, K.; Sheng, M.

The chemical toolbox for monitoring protein fatty acylation and prenylation. Nature Chemical Biology, 2010, ISSN: 1552-4469

Hannoush, R,; Sun, J.

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood, 2010, ISSN: 1528-0020

Strasser, G.; Kaminker, J.; Tessier-Lavigne, M.

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. Journal of Clinical Investigation, 2010, ISSN: 1558-8238

Brightbill, H.; Jeet, S.; Lin, Z.; Yan, D.; Zhou, M.; Tan, M.; Nguyen, A.; Yeh, S.; Delarosa, D.; Leong, S.; Wong, T.; Chen, Y.; Ultsch, M.; Luis, E.; Ramani, S.; Jackman, J.; Gonzalez, L.; Dennis, M.; Chuntharapai, A.; DeForge, L.; Meng, Y.; Xu, M.; Eigenbrot, C.; Lee, W.; Refino, C.; Balazs, M.; Wu, L.

Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum interference. Journal of Immunological Methods, 2010, ISSN: 0022-1759

McCutcheon, K.; Quarmby, V.; Song, A.

Independent Adjudication of Symptomatic Heart Failure With the Use of Doxorubicin and Cyclophosphamide Followed by Trastuzumab Adjuvant Therapy: A Combined Review of Cardiac Data From the National Surgical Adjuvant Breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Russell, S.; Blackwell, K.; Lawrence, J.; Pippen, J. E. Jr.; Roe, M.; Wood, F.; Paton, V.; Holmgren, E; Mahaffey, K.

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Jones, J.; Kayagaki, N.; Broz, P.; Henry, T.; Newton, K. O'Rourke, K.; Chan, S.; Dong, J.; Qu, Y.; Roose-Girma, M.; Dixit, V.; Monack, D.

Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941 Drug Metabolism and Disposition, 2010, ISSN: 1521-009X

Salphati, L.; Wong, H.; Belvin, M.; Bradford, D.; Edgar, K.; Prior, W.; Sampath, D.; Wallin, J.

View on PubMed
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell, 2010, ISSN: 1535-6108

Noushmehr, H.; Weisenberger, D.J.; Diefes, K.; Phillips, H.S.; Pujara, K.; Berman, B.P.; Pan, F.; Pelloski, C.E.; Sulman, E.P.; Bhat, K.P.; Verhaak, R.G.W.; Hoadley, K.A.; Hayes, D.N.; Perou, C.M.; Schmidt, H.K.; Ding, L.; Wilson, R.K.; Van Den Berg, D.; Shen, H.; Bengtsson, H.; Neuvial, P.; Cope, L.M.; Buckley, J.; Herman, J.G.; Baylin, S.B.; Laird, P.W.; Aldape, K.

The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature, 2010, ISSN: 1476-4687

Lee, W.; Jiang, Z.; Liu, J.; Haverty, P.; Guan, Y.; Stinson, J.; Yue, P.; Zhang, Y.; Pant, K.; Bhatt, D.; Ha, C.; Johnson, S.; Kennemer ,M.; Mohan, S.; Nazarenko, I.; Watanabe, C.; Sparks, A.; Shames, D.; Gentleman, R.; de Sauvage, F.; Stern, H.; Pandita, A.; Ballinger, D.; Drmanac, R.; Modrusan, Z.; Seshagiri, S.; Zhang, Z.

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site Journal of Biological Chemistry, 2010, ISSN: 1083-351X

Maun, H.R.; Wen, X.; Lingel, A.; de Sauvage, F.J.; Lazarus, R.A.; Scales, S.J.; Hymowitz, S.G.

View on PubMed
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature, 2010, ISSN: 0028-0836

Baranzini, S.; Mudge, J.; van Velkinburgh, J.; Khankhanian, P.; Khrebtukova, I.; Miller, N.; Zhang, L.; Farmer, A.; Bell, C.; Kim, R.; May, G.; Woodward, J.; Caillier, S.; McElroy, J.; Gomez, R.; Pando, M.; Clendenen, L.; Ganusova, E.; Schilkey, F.; Ramaraj, T.; Khan, O.; Huntley, J.; Luo, S.; Kwok, P.; Wu, T.; Schroth, G.; Oksenberg, J.; Hauser, S.; Kingsmore, S.

Signalling lessons from death receptors: the importance of cleavage. Nature Cell Biology, 2010, ISSN: 1476-4679

Dixit, V.

Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathogens, 2010, ISSN: 1553-7374

Carlsson, F.; Kim, J.; Dumitru, C.; Barck, K.; Carano, R.; Sun, M.; Diehl, L.; Brown, E.

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Herbst, R.; Eckhardt, S.; Kurzrock, R.; Ebbinghaus, S.; O'Dwyer, P.; Gordon, M.; Novotny, W.; Goldwasser, M.; Tohnya, T.; Lum, B.; Ashkenazi, A. Jubb, A.; Mendelson, D.

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nature Biotechnology, 2010, ISSN: 1546-1696

Singh, M.; Lima, A.; Molina, R.; Hamilton, P.; Clermont, A.; Devasthali, V.; Thompson, J.; Cheng, J.H.; Bou-Reslan, H.; Ho, C.C.K.; Cao, T., Lee, C., Nannini, M.; Fuh, G.; Carano, R.; Koeppen, H.; Yu, R.; Forrest, W.; Plowman, G.; Johnson, Leisa

View on PubMed
Phase I Study of Trastuzumab-DM1, a HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Krop, I.; Beeram, M.; Modi, S.; Jones, S.; Holden, S.; Yu, W.; Girish, S.; Tibbitts, J.; Yi, J.-H.; Sliwkowski, M.; Jacobson, F.; Lutzker, S.; Burris, H.

Bevacizumab and Recurrent Malignant Gliomas: A European Perspective: Reply to W. Wick et al. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Friedman, H.; Prados, M.; Wen, P.; Mikkelsen, T.; Schiff, D.; Abrey, L.; Yung, W.; Paleologos, N.; Nicholas, M.; Jensen, R.; Vredenburgh, J.; Huang, J.; Zheng, M.; Cloughesy, T.

A population pharmacokinetic model for rituximab lin rheumatoid arthritis patients during a phase II clinical study Journal of Clinical Pharmacology, 2004, ISSN: 0091-2700

Ng, C.; Bruno, R.; Combs, D.; Davies, B.

Development of a Two-Part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling Journal of Biological Chemistry, 2010, ISSN: 0021-9258

Jackman, J.; Chen, Y.; Huang, A.; Moffat, B.; Scheer, J.; Leong, S.; Lee, W.; Zhang, J.; Sharma, N.; Lu, Y.; Iyer, S.; Shields, R.; Chiang, N.; Bauer, M.; Waley, D.; Roose-Girma, M.; Vandlen, R.; Yansura, D.; Wu, Y.; Wu, L.

View on PubMed
Functions of Type II Pneumocyte-Derived Vascular Endothelial Growth Factor in Alveolar Structure, Acute Inflammation, and Vascular Permeability. American Journal of Pathology, 2010, ISSN: 0002-9440

Mura, M.; Binnie, M.; Han, B.; Li, C; Andrade, C.; Shiozaki, A.; Zhang, Y.; Ferrara, N.; Hwang, D.; Waddell, T.; Keshavjee, S.; Liu, M.

Genetic Dissection of the Function of Hindbrain Axonal Commissures. PLoS Biology, 2010, ISSN: 1544-9173

Renier, N.; Schonewille, M.; Giraudet, F.; Badura, A.; Tessier-Lavigne, M.; Avan, P.; de Zeeuw, C.; Chedotal, A.

Interplay of Dissolution, Solubility and Non-Sink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor, GDC-0449, in Dogs: An Investigation using Preclinical Studies and Physiologically- Based Pharmacokinetic Modeling Drug Metabolism and Disposition, 2010, ISSN: 0090-9556

Wong, H.; Theil, F.-P; Cui, Y; Marsters, J.; Khojasteh S.C.; Vernillet, L.; La, H.; Song, X.; Wang, H.; Morinello, E.; Deng, Y.; Hop, C.

View on PubMed
Cancer Therapy Reform Science, 2010, ISSN: 0036-8075

Levinson, A.D.

Utility of Influenza Vaccination for Oncology Patients. Journal of Clinical Oncology, 2010, ISSN: 1527-7755

Pollyea, D.A.; Brown, J.M.Y.; Horning, S.J.

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Cliogenesis. Science Signaling, 2009, ISSN: 1937-9145

Ashique, A.M.; Choe, Y.; Karlen, M.; May, S.R.; Phamluong, K.; Solloway, M.J.; Ericson, J.; Peterson, S.A.

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma. Cancer Cell, 2010, ISSN: 1878-3686

Chen, R.; Nishimura, M.C.; Bumbaca, S.M.; Kharbanda, S.; Forrest, W.F.; Kasman, I.M.; Greve, J.M.; Soriano, R.H.; Gilmour, L.L.; Rivers, C.S.; Modrusan, Z.; Nacu, S.; Guerrero, S.; Edgar, K.A.; Wallin, J.J.; Lamszus, K.; Westphal, M.; Heim, S.; James, C.D.; VandenBerg, S.R.; Costello, J.F.; Moorefield, S.; Cowdrey, C.J.; Prados, M.; Phillips, H.S.

Rituximab Plus Fludarabine and Cyclophosphamide Prolongs Progression-Free Survival Compared With Fludarabine and Cyclophosphamide Alone in Previously Treated Chronic Lymphocytic Leukemia. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Robak, T.; Dmoszynska, A.; Solal-Celigny, P.; Warzocha, K.; Loscertales, J.; Catalano, J.; Afanasiev, B.V.; Larratt, L.; Geisler, C.H.; Montillo, M.; Zyuzgin, I.; Ganly, P.S.; Dartigeas, C.; Rosta, A.; Maurer, J.; Mendila, M.; Saville, M.W.; Valente, N.; Wenger, M.K.; Moiseev, S.I.

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nature Cell Biology, 2010, ISSN: 1465-7392

Pereg, Y.; Liu, B.; O'Rourke, K.; Sagolla, M.; Dey, A.; Komuves, L.; French, D.; Dixit, V.

Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluroination. Chemical Research in Toxicology, 2010, ISSN: 1520-5010

Driscoll, J.P.; Aliagas, I.; Harris, J.J.; Halladay, J.S.; Khatib-Shahidi, S.; Deese, A.; Segraves, N.; Khojasteh-Bakht, S.C.

Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

Wong, K.; Valdez, P.; Tan, C.; Yeh, S.; Hongo, J.; Ouyang, W.

Therapeutic antibody targeting of individual Notch receptors. Nature, 2010, ISSN: 1476-4687

Wu, Y.; Cain-Hom, C.; Choy, L.; Hagenbeek, T.J.; de Leon, G.P.; Chen, Y.; Finkle, D.; Venook, R.; Wu, X.; Ridgway, J.; Schahin-Reed, D.; Dow, G.J.; Shelton, A.; Stawicki, S.; Watts, R.J.; Zhang, J.; Choy, R.; Howard, P.; Kadyk, L.; Yan, M.; Zha, J.; Callahan, C.A.; Hymowitz, S.G.; Siebel, C.W.

View on PubMed
Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2). Biochemistry, 2010, ISSN: 1520-4995

Lovitt, B.; Vanderporten, E.C.; Sheng, Z.; Zhu, H.; Drummond, J.; Liu, Y.

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth. Cell, 2010, ISSN: 1097-4172

Bais, C.; Wu, X.; Yao, J.; Yang, S.; Crawford, Y.; McCutcheon, K.; Tan, C.; Kolumam, G.; Vernes, J.M.; Eastham-Anderson, J.; Haughney, P.; Kowanetz, M.; Hagenbeek, T.; Kasman, I.; Reslan, H.B.; Ross, J.; Van Bruggen, N.; Carano, R.A.; Meng, Y.J.; Hongo, J.A.; Stephan, J.P.; Shibuya, M.; Ferrara, N.

An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G. Current Opinion in Structural Biology, 2010, ISSN: 1879-033X

Tesar, D.B.; Bjorkman, P.J.

IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathogens, 2010, ISSN: 1553-7366

Stoddart, C.A.; Keir, M.E.; McCune, J.M.

Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature, 2010, ISSN: 1476-4687

Chung, I.; Akita, R.; Vandlen, R.; Toomre, D.; Schlessinger, J.; Mellman, I.

Characteristics of rhVEGF Release from Topical Hydrogel Formulations. Pharmaceutical Research, 2010, ISSN: 0724-8741

Ji, J.Y.A.; Liu, J.; Shire, S.J.; Kamerzell, T.J.; Hong, S.; Billeci, K.; Shen, Y.; Wang, Y.J.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. Journal of Clinical Investigation, 2010, ISSN: 0021-9738

O'Toole, J.F.; Liu, Y.J.; Davis, E.E.; Westlake, C.J.; Attanasio, M.; Otto, E.A.; Seelow, D.; Nurnberg, G.; Becker, C.; Nuutinen, M.; Karppa, M.; Ignatius, J.; Uusimaa, J.; Pakanen, S.; Jaakkola, E.; van den Heuvel, L.P.; Fehrenbach, H.; Wiggins, R.; Goyal, M.; Zhou, W.B.; Wolf, M.T.F.; Wise, E.; Helou, J.; Allen, S.J.; Murga-Zamalloa, C.A.; Hildebrandt, F.; et al.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 2010, ISSN: 1476-4687

Hatzivassiliou, G.; Song, K.; Yen, I.; Brandhuber, B.J.; Anderson, D.J.; Alvarado, R.; Ludlam, M.J.; Stokoe, D.; Gloor, S.L.; Vigers, G.; Morales, T.; Aliagas, I.; Liu, B.; Sideris, S.; Hoeflich, K.P.; Jaiswal, B.S.; Seshagiri, S.; Koeppen, H.; Belvin, M.; Friedman, L.S.; Malek, S.

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nature Structural & Molecular Biology, 2010, ISSN: 1545-9985

Vrljic, M.; Strop, P.; Ernst, J.A.; Sutton, R.B.; Chu, S.; Brunger, A.T.

Mature dendritic cells use endocytic receptors to capture and present antigens. Proceedings of the National Academy of Sciences, 2010, ISSN: 0027-8424

Platt, C.D.; Ma, J.K.; Chalouni, C.; Ebersold, M.; Bou-Reslan, H.; Carano, R.A.D.; Mellman, I.; Delamarre, L.

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer. Journal of Clinical Oncology, 2010, ISSN: 0732-183X

Makhija, S.; Amler, L.; Glenn, D.; Ueland, F.; Gold, M.; Dizon, D.; Paton, V.; Lin, C.; Januario, T.; Ng, K.; Strauss, A.; Kelsey, S.; Sliwkowski, M.; Matulonis, U.

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood, 2010, ISSN: 0006-4971

Priceman, S.; Sung, J.; Shaposhnik, Z.; Burton, J.; Torres, C.; Moughon, D.; Johnson, M.; Lusis, A.; Cohen, D.; Iruela-Arispe, M.; Wu, L.

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines. Cell, 2010, ISSN: 0092-8674

Bingol, B.; Wang, C.F.; Arnott, D.; Cheng, D.M.; Peng, J.M.; Sheng, M.

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature, 2009, ISSN: 0028-0836

Tran., T.S.; Rubio, M.E.; Clem, R.L.; Johnson, D.; Case, L.; Tessier-Lavigne, M.; Huganir, R.L.; Ginty, D.D.; Kolodkin, A.L.

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature, 2010, ISSN: 1476-4687

Schwickart, M.; Huang, X.; Lill, J.R.; Liu, J.; Ferrando, R.; French, D.M.; Maecker, H.; O'Rourke, K.; Bazan, F.; Eastham-Anderson, J.; Yue, P.; Dornan, D.; Huang, D.C.; Dixit, V.M.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathlology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Munoz, M.; Heimesaat, M.M.; Danker, K.; Struck, D.; Lohmann, U.; Plickert, R.; Bereswill, S.; Fischer, A.; Dunay, I.R.; Wolk, K.; Loddenkemper, C.; Krell, H.W.; Libert, C.; Lund, L.R.; Frey, O.; Holscher, C.; Iwakura, Y.; Ghilardi, N.; Ouyang, W.J.; Kamradt, T.; Sabat, R.; Liesenfeld, O.

Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization. Analytical Biochemistry, 2010, ISSN: 1096-0309

Connolly, B.; Patapoff, T.W.; Wang, Y.J.; Moore, J.M.; Kamerzell, T.J.

ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2010, ISSN: 1528-0020

Niessen, K.; Zhangm, G.; Ridgway, J.B.; Chen, H.; Yan, M.

Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2+ and possible function in short-term synaptic plasticity. EMBO Journal, 2010, ISSN: 0261-4189

Rodriguez-Castaeda, F.; Maestre-Martinez, M.; Coudevylle, N.; Dimova, K.; Junge, H.; Lipstein, N.; Lee, D.; Becker, S.; Brose, N.; Jahn, O.; Carlomagno, T.; Griesinger, C.

Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 2009, ISSN: 1553-7366

Bitter, W.; Houben, E.N.G.; Bottai, D.; Brodin, P.; Brown, E..J.; Cox, J.S.; Derbyshire, K.; Fortune, S.M.; Gao, L.-Y.; Liu, J.; Van Pittius, N.C.G.; Pym, A.S.; Rubin, E.J.; Sherman, D.R.; Cole, S.T.; Brosch, R.

The inflammasomes - art. no. e1000510 PLoS Pathogens, 2009, ISSN: 1553-7366

Lamkanfi, M.; Dixit, V.

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. Journal of Cell Biology, 2010, ISSN: 0021-9525

Xu, Y.L.; Yuan, L.; Mak, J.; Pardanaud, L.; Caunt, M.; Kasman, I.; Larrivee, B.; del Toro, R.; Suchting, S.; Medvinsky, A.; Silva, J.; Yang, J.; Thomas, J.L.; Koch, A,W.; Alitalo, K.; Eichmann, A.; Bagri A.

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Xi, H.; Katschke, K.J. Jr.; Helmy, K.Y.; Wark, P.A.; Kljavin, N.; Clark, H.; Eastham-Anderson, J.; Shek, T.; Roose-Girma, M.; Ghilardi, N.; van Lookeren Campagne, M.

Stromal Cell-Derived Factor-1/CXCL12 Contributes to MMTV-Wnt1 Tumor Growth Involving Gr1+CD11b+ Cells PLoS ONE, 2010, ISSN: 1932-6203

Liu, B.Y.; Soloviev, I.; Chang, P.; Lee, J.; Huang, X.; Zhong, C.; Ferrara, N.; Polakis, P.; Sakanaka, C.

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development. Cell, 2010, ISSN: 0092-8674

Lichtenberger, B.M.; Tan, P.K.; Niederleithner, H.; Ferrara, N.; Petzelbauer, P.; Sibilia, M.

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo. Developmental Cell, 2010, ISSN: 1534-5807

Camerer, E.; Barker, A.; Duong, D.N.; Ganesan, R.; Kataoka, H.; Cornelissen, I.; Darragh, M.R.; Hussain, A.; Zheng, Y.W.; Srinivasan, Y.; Brown, C.; Xu, S.M.; Regard, J.B.; Lin, C.Y.; Craik, C.S.; Kirchhofer, D.; Coughlin, S.R.

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer Journal of Medicinal Chemistry, 2010, ISSN: 1520-4804

Sutherlin, D.P.; Sampath, D.; Berry, M.; Castanedo, G.; Chang, Z.; Chuckowree, I.; Dotson, J.; Folkes, A.; Friedman, L.; Goldsmith, R.; Heffron, T.; Lee, L.; Lesnick, J.; Lewis, C.; Mathieu, S.; Nonomiya, J.; Olivero, A.; Pang, J.; Prior, W.W.; Salphati, L.; Sideris. S.; Tian, Q.; Tsui, V.; Wan, N.C.; Wang, S.; Wiesmann, C.; Wong, S.; Zhu, B.Y.

View on PubMed
Chronic DLL4 blockade induces vascular neoplasms. Nature, 2010, ISSN: 1476-4687

Yan, M.; Callahan, C.A.; Beyer, J.C.; Allamneni, K.P.; Zhang, G.; Ridgway, J.B.; Niessen, K.; Plowman, G.D.

Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo. PLoS ONE, 2010, ISSN: 1932-6203

Esue, O.; Rupprecht, L.; Sun, S.X.; Wirtz, D.

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. Journal of Experimental Medicine, 2010, ISSN: 1540-9538

Crellin, N.K.; Trifari, S.; Kaplan, C.D.; Cupedo, T.; Spits, H.

Reconstitution of a Frizzled8.Wnt3a.LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6. Journal of Biological Chemistry, 2010, ISSN: 1083-351X

Bourhis, E.; Tam, C.; Franke, Y.; Bazan, J.F.; Ernst, J.; Hwang, J.; Costa, M.; Cochran, A.G.; Hannoush, R.N.

View on PubMed
Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity. A Validation Study. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Bauer, J.W.; Petri, M.; Batliwalla, F.M.; Koeuth, T.; Wilson, J.; Slattery, C.; Panoskaltsis-Mortari, A.; Gregersen, P.K.; Behrens, T.W.; Baechler EC

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Li, B.; Xi, H.K.; Diehl, L.; Lee, W.P.; Sturgeon, L.; Chinn, J.; DeForge, L.; Kelley, R.F.; Wiesmann, C.; Campagne, M.V.; Sidhu, S.S.

Characterization of oligosaccharides in recombinant tissue plasminogen activator produced in Chinese Hamster Ovary Cells: two decades of analytical technology development. Analytical Chemistry, 2009, ISSN: 0003-2700

Borisov, O.V.; Field, M.; Ling, V.T.; Harris, R.J.

Somatic mutations in p85alpha promote tumorigenesis through Class IA PI3K activation. Cancer Cell, 2009, ISSN: 1878-3686

Jaiswal, B.S.; Janakiraman, V.; Kljavin, N.M.; Chaudhuri, S.; Stern, H.M.; Wang, W.; Kan, Z.; Dbouk, H.A.; Peters, B.A.; Waring, P.; Dela Vega, T.; Kenski, D.M.; Bowman, K.K.; Lorenzo, M.; Li, H.; Wu, J.; Modrusan, Z.; Stinson, J.; Eby, M.; Yue, P.; Kaminker, J.S.; de Sauvage, F.J.; Backer, J.M.; Seshagiri, S.

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins - art. no. e1000218. Plos Biology, 2009, ISSN: 1544-9173

Tonikian, R.; Xin, X.F.; Toret, C.P.; Gfeller, D.; Landgraf, C.; Panni, S.; Paoluzi, S.; Castagnoli, L.; Currell, B.; Seshagiri, S.; Yu, H.Y.; Winsor, B.; Vidal, M.; Gerstein, M.B.; Bader, G.D.; Volkmer, R.; Cesareni, G.; Drubin, D.G.; Kim, P.M.; Sidhu, S.S.; Boone, C.

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions - art. no. e1000696. PLoS Genetics, 2009, ISSN: 1553-7390

Barcellos, L.F.; May, S.L.; Ramsay, P.P.; Quach, H.L.; Lane, J.A.; Nititham, J.; Noble, J.A.; Taylor, K.E.; Quach, D.L.; Chung, S.A.; Kelly, J.A.; Moser, K.L.; Behrens, T.W.; Seldin, M.F.; Thomson, G.; Harley, J.B.; Gaffney, P.M.; Criswell, L.A.

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors: insight into heterotrimeric IL-1 signaling complexes. Structure, 2009, ISSN: 1878-4186

Lingel, A.; Weiss, T.M.; Niebuhr, M.; Pan, B.; Appleton, B.A.; Wiesmann, C.; Bazan, J.F.; Fairbrother, W.J.

Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides. Pharmaceutical Research, 2009, ISSN: 0724-8741

Kosky, A.A.; Dharmavaram, V.; Ratnaswamy, G.; Manning, M.C.

Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography. Analytical Chemistry, 2009, ISSN: 1520-6882

Farnan, D.; Moreno, G.T.

Carboxylate-dependent gelation of a monoclonal antibody. Pharmaceutical Research, 2009, ISSN: 0724-8741

Esue, O.; Kanai, S.; Liu, J.; Patapoff, T.W.; Shire, S.J.

Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science, 2009, ISSN: 0036-8075

Yauch, R.L.; Dijkgraaf, G.J.P.; Alicke, B.; Januario,T.; Ahn, C.P.; Holcomb, T.; Pujara, K.; Stinson, J.; Callahan, C.A.; Tang, T.; Bazan, J.F.; Kan, Z.; Seshagiri, S.; Hann, C.L.; Gould, S.E.; Low, J.A.; Rudin, C.M.; de Sauvage, F.J.

Masking MALT1: the paracaspase's potential for cancer therapy. Journal of Experimental Medicine, 2009, ISSN: 1540-9538

Vucic, D.; Dixit, V.M.

Formulation and manufacturability of biologics. Current Opinion in Biotechnology, 2009, ISSN: 1879-0429

Shire, S.J.

Retinoic acid from the meninges regulates cortical neuron generation. Cell, 2009, ISSN: 0092-8674

Siegenthaler, J.A.; Ashique, A.M.; Zarbalis, K.; Patterson, K.P.; Hecht, J.H.; Kane, M.A.; Folias, A.E.; Choe, Y.; May, S.R.; Kume, T.; Napoli, J.L.; Peterson, A.S.; Pleasure, S.J.

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. Journal of Biological Chemistry, 2009, ISSN: 1083-351X

Varfolomeev, E.; Alicke, B.; Elliott, J.M.; Zobel, K.; West, K.; Wong, H.; Scheer, J.M.; Ashkenazi, A.; Gould, S.E.; Fairbrother, W.J.; Vucic, D.

Role of sensitivity analyses in assessing progression-free survival in late-stage oncology trials. Journal of Clinical Oncology, 2009, ISSN: 1527-7755

Bhattacharya, S.; Fyfe, G.; Gray, R.J.; Sargent, D.J.

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110 alpha and are disrupted in oncogenic p85 mutants. Proceedings of the National Academy of Sciences, 2009, ISSN: 0027-8424

Wu, H.Y.; Shekar, S.C.; Flinn, R.J.; El-Sibai, M.; Jaiswal, B.S.; Sen, K.I.; Janakiraman, V.; Seshagiri, S.; Gerfen, G.J.; Girvin, M.E.; Backer, J.M.

Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry. Analytical Chemistry, 2009, ISSN: 1520-6882

Yu, X.C.; Borisov, O.V.; Alvarez, M.; Michels, D.A.; Wang, Y.J.; Ling, V.

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Lee, E.F.; Fedorova, A.; Zobel, K.; Boyle, M.J.; Yang, H.; Perugini, M.A.; Colman, P.M.; Huang, D.C.S.; Deshayes, K.; Fairlie, W.D.

Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Socinski, M.A.; Langer, C.J.; Huang, J.E.; Kolb, M.M.; Compton, P.; Wang, L.; Akerley, W.

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nature Genetics, 2009, ISSN: 1061-4036

Gateva, V.; Sandling, J.K.; Hom, G.; Taylor, K.E.; Chung, S.A.; Sun, X.; Ortmann, W.; Kosoy, R.; Ferreira, R.C.; Nordmark, G.; Gunnarsson, I.; Svenungsson, E.; Padyukov, L.; Sturfelt, G.; Jonsen, A.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Baechler, E.C.; Brown, E.E.; Alarcon, G.S.; Edberg, J.C.; Ramsey-Goldman, R.; McGwin, G.; Reveille, J.D.; Vila, L.M.; Graham, R.R.; et al.

Bi-directional SIFT predicts a subset of activating mutations PLoS ONE, 2009, ISSN: 1932-6203

Lee, W.; Zhang, Y.; Mukhyala, K.; Lazarus, R.A.; Zhang, Z.

View on PubMed
Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 2009, ISSN: 1878-4186

Ganesan, R.; Eigenbrot, C.; Wu, Y.; Liang, W.C.; Shia, S.; Lipari, M.T.; Kirchhofer, D.

View on PubMed
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. Journal of Cell Biology, 2009, ISSN: 1540-8140

Lamkanfi, M.; Mueller, J.L.; Vitari, A.C.; Misaghi, S.; Fedorova. A.; Deshayes, K.; Lee, W.P.; Hoffman, H.M.; Dixit, V.M.

Antigen choice in adoptive T-cell therapy of cancer. Current Opinion in Immunology, 2009, ISSN: 0952-7915

Offringa, R.

Local guidance of emerging vessel sprouts requires soluble Flt-1 Developmental Cell, 2009, ISSN: 1534-5807

Chappell, J.C.; Taylor, S.M.; Ferrara, N.; Bautch, V.L.

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

Gill, H.S.; Tinianow, J.N.; Ogasawara, A.; Flores, J.E.; Vanderbilt, A.N.; Raab, H.; Scheer, J.M.; Vandlen, R.; Williams, S.P.; Marik, J.

Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity. Journal of Immunological Methods, 2009, ISSN: 0022-1759

Bond, E.; Adams, W.C.; Smed-Sorensen, A.; Sandgren, K.J.; Perbeck, L.; Hofmann, A.; Andersson, J.; Lore, K.

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. New England Journal of Medicine, 2009, ISSN: 0028-4793

Von Hoff, D.D.; LoRusso, P.M.; Rudin, C.M.; Reddy, J.C.; Yauch, R.L.; Tibes, R.; Weiss, G.J.; Borad, M.J.; Hann, C.L.; Brahmer, J.R.; Mackey, H.M.; Lum, B.L.; Darbonne, W.C.; Marsters, J.C.; de Sauvage, F.J.; Low J.A.

Brief Report: treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. New England Journal of Medicine, 2009, ISSN: 0028-4793

Rudin, C.M.; Hann, C.L.; Laterra, J.; Yauch, R.L.; Callahan, C.A.; Fu, L.; Holcomb, T.; Stinson, J.; Gould, S.E.; Coleman, B.; LoRusso, P.M.; Von Hoff, D.D.; de Sauvage, F.J.; Low, J.A.

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. PLoS ONE, 2009, ISSN:

Blum, G.; Weimer, R.M.; Edgington, L.E.; Adams, W.; Bogyo, M.

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin's lymphoma. Blood, 2009, ISSN: 1528-0020

Dornan, D.; Bennett, F.; Chen, Y.; Dennis, M.; Eaton D.; Elkins, K.; French, D.; Go, M.A.T.; Jack, A.; Junutula, J.R.; Koeppen, H.; Lau, J.; McBride, J.; Rawstron, A.; Shi, X.; Yu, N.; Yu, S.-F.; Yue, P.; Zheng, B.; Ebens, A.; Polson, A.G.

Structural ties between cholesterol transport and morphogen signaling. Cell, 2009, ISSN: 1097-4172

Bazan, J.F.; de Sauvage, F.J.

A highly annotated whole-genome sequence of a Korean individual. Nature, 2009, ISSN: 0028-0836

Kim, J.I.; Ju, Y.S.; Park, H.; Kim, S.; Lee, S.; Yi, J.H.; Mudge, J.; Miller, N.A.; Hong, D.; Bell, C.J.; Kim, H.S.; Chung, I.S.; Lee, W.C.; Lee, J.S.; Seo, S.H.; Yun, J.Y.; Woo, H.N.; Lee, H.; Suh, D.; Lee, S.; Kim, H.J.; Yavartanoo, M.; Kwak, M.; Zheng, Y.; Lee, M.K.; Park, H.; Kim, J.Y.; ... Wu, T.D.; Kim, H.; Yang, K.-S.; ...Kingsmore, S.F.; Seo, J.-S.

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Chung, S.A.; Tian, C.; Taylor, K.E.; Lee, A.T.; Ortmann, W.A.; Hom, G.; Graham, R.R.; Nititham, J.; Kelly, J.A.; Morrisey, J.; Wu, H.; Yin, H.; Alarcon-Riquelme, M.E.; Tsao, B.P.; Harley, J.B.; Gaffney, P.M.; Moser, K.L.; Manzi, S.; Petri, M.; Gregersen, P.K.; Langefeld, C.D.; Behrens, T.W.; Seldin, M.F.; Criswell, L.A.

Investigation of sample preparation artifacts formed during the enzymatic release of N-Linked glycans prior to analysis by capillary electrophoresis. Analytical Chemistry, 2009, ISSN: 0003-2700

Liu, Y.; Salas-Solano, O.; Gennaro, L.A.

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. Journal of Cell Biology, 2009, ISSN: 0021-9525

Farr, G.A.; Hull, M.; Mellman, I.; Caplan, M.J.

FAM29A promotes microtubule amplification via recruitment of the NEDD1-γ-tubulin complex to the mitotic spindle. Journal of Cell Biology, 2008, ISSN:

Zhu, H.; Coppinger, J.A.; Jang, C.Y.; Yates J.R.III; Fang, G.

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Zheng, M.; Huang, J.E.; Friedman, H.S.; Prados, M.; Wen, P.Y.; Mikkelsen, T.; Schiff, D.; Abrey, L.E.; Yung, W.K.; Paleologos, N.; Nicholas, M.K.; Jensen, R.; Vrdenburgh, J.; Cloughesy, T.

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Current Biology, 2009, ISSN: 1879-0445

Endoh-Yamagami, S.; Evangelista, M.; Wilson, D.; Wen, X.; Theunissen, J.-W.; Phamluong, K.; Davis, M.; Scales, S.J.; Solloway, M.J.; de Sauvage, F.J.; Peterson, A.S.

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Leow, C.C.; Wang, B.; Ross, J.; Chan, S.M.; Zha, J.; Carano, R.A.D.; Frantz, G.; Shen, M.M.; deSauvage, F.J.; Gao, W.-Q.

Breaking into bone biology Nature Medicine, 2009, ISSN:

Choi, Y.; Walsh, M.C.; Arron, J.R.

Navigating the deubiquitinating proteome with a CompPASS.[comment]. Cell, 2009, ISSN: 1097-4172

Jackson, P.K.

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nature Immunology, 2009, ISSN: 1529-2916

Trifari, S.; Kaplan, C.D.; Tran, E.H.; Crellin, N.K.; Spits, H.

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry, 2009, ISSN: 1520-4995

Bourhis, E.; Lingel, A.; Phung, Q.; Fairbrother, W.J.; Cochran, A.G.

Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. Journal of the American Chemical Society, 2009, ISSN: 0002-7863

Burns, N.Z.; Krylova, I.N.; Hannoush, R.N.; Baran, P.S.

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Pickert, G.; Neufert, C.; Leppkes, M.; Zheng, Y.; Wittkopf, N.; Warntjen, M.; Lehr, H.A.; Hirth, S.; Weigmann, B.; Wirtz, S.; Ouyang, W.; Neurath, M.F.; Becker, C.

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Nojiri, M.; Loyet, K.M.; Klenchin, V.A.; Kabachinski, G.; Martin, T.F.J.

IL-33 raises alarm. Immunity, 2009, ISSN: 1097-4180

Lamkanfi, M.; Dixit, V.M.

TSPAN12 regulates retinal vascular development by promoting Norrin but not Wnt-induced FZD4/β-catenin signaling. Cell, 2009, ISSN: 1097-4172

Junge, H.J.; Yang, S.; Burton, J.B.; Paes, K.; Shu, X.; French, D.M.; Costa, M.; Rice, D.S.; Ye, W.

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study. Journal of Immunological Methods, 2009, ISSN: 1872-7905

Loyet, K.M.; Deng, R.; Liang, W.C.; Wu, Y.; Lowman, H.B.; DeForge, L.E.

View on PubMed
The structure of SHH in complex with HHIP reveals a recognition role for the SHH pseudo-active site in signaling Nature Structural & Molecular Biology, 2009, ISSN: 1545-9985

Bosanac, I.; Maun, H.R.; Scales, S.J.; Wen, X.; Lingel, A.; Bazan, J.F.; de Sauvage, F.J.; Hymowitz, S.G.; Lazarus, R.A.

View on PubMed
Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects. Journal of Clinical Pharmacology, 2009, ISSN: 0091-2700

Eley, T.; Luo, F.R.; Agrawal, S.; Sanil, A.; Manning, J.; Li, T.; Blackwood-Chirchir, A.; Bertz, R.

Follicular lymphoma in the United States: First report of the National LymphoCare Study. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Friedberg, J.W.; Taylor, M.D.; Cerhan, J.R.; Flowers, C.R.; Dillon, H.; Farber, C.M.; Rogers, E.S.; Hainsworth, J.D.; Wong, E.K.; Vose, J.M.; Zelenetz, A.D.; Link, B.K.

Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab. Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Sandler, A.B.; Schiller, J.H.; Gray, R.; Dimery, I.; Brahmer, J.; Samant, M.; Wang, L.I.; Johnson, D.H.

The PRL-1149 G/T polymorphism and rheumatoid arthritis susceptibility. Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Lee, Y.C.; Raychaudhuri, S.; Cui, J.; De Vivo, I.; Ding, B.; Alfredsson, L.; Padyukov, L.; Costenbader, K.H.; Selelstad, M.; Graham, R.R.; Klareskog, L.; Gregersen, P.K.; Plenge, R.M.; Karlson, E.W.

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell, 2009, ISSN: 1934-5909

Hofmann, I.; Stover, E.H.; Cullen, D.E.; Mao, J.; Morgan, K.J.; Lee, B.H.; Kharas, M.G.; Miller, P.G.; Cornejo, M.G.; Okabe, R.; Armstrong, S.A.; Ghilardi, N.; Gould, S.; de Sauvage, F.J.; McMahon, A.P.; Ghilliland, D.G.

Targeted depletion of lymphotoxin-α-expressing TH1 and TH17 cells inhibits autoimmune disease. Nature Medicine, 2009, ISSN: 1078-8956

Chiang, E.Y.; Kolumam, G.A.; Yu, X.; Francesco, M.; Ivelja, S.; Peng, I.; Gribling, P.; Shu, J.; Lee, W.P.; Refino, C.J.; Balazs, M.; Paler-Martinez, A.; Nguyen, A.; Young, J.; Barck, K.H.; Carano, R.A.D.; Ferrando, R.; Diehl, L.; Chatterjea, D.; Grogan, J.L.

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry, 2009, ISSN: 1520-4804

Aliagas-Martin, I.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Huang, O.W.; Hunsaker. T.; Kleinheinz, T.; Krueger, E.; Liang, J.; Moffat, J.; Phillips, G.; Pulk, R.; Rawson, T.E.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhu, B.Y.; Cochran, A.G.

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell, 2009, ISSN: 1097-4172

Jin, Z.; Li, Y.; Pitti, R.; Lawrence, D.; Pham, V.C.; Lill, J.R.; Ashkenazi, A.

Combined targeting of BRAF and CRAF or BRAF and P13K effector pathways is required for efficacy in NRAS mutant tumors. PloS ONE, 2009, ISSN: 1932-6203

Jaiswal, B.S.; Janakiraman, V.; Klavin, N.M.; Eastham-Anderson, J.; Cupp, J.E.; Liang, Y.; Davis, D.P.; Hoeflich, K.P.; Seshagiri, S.

Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathogens, 2009, ISSN: 1553-7374

Collins, C.A.; De Maziere, A.; van Dijk, S.; Carlsson, F.; Klumperman, J.; Brown, E.J.

Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. Journal of Experimental Medicine, 2009, ISSN: 0022-1007

Haines, C.J.; Giffon, T.D.; Lu, L.-S.; Lu, X.; Tessier-Lavigne, M.; Ross, D.T.; Lewis, D.B.

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell, 2009, ISSN: 1535-6108

Junttila, T.T.; Akita, R.W.; Parsons, K.; Fields, C.; Lewis Phillips, G.D.; Friedman, L.S.; Sampath, D.; Sliwkowski, M.X.

An analytical system for the characterization of highly heterogeneous mixtures of N-linked oligosaccharides. Analytical Biochemistry, 2009, ISSN: 1096-0309

Briggs, J.B.; Keck, R.G.; Ma, S.; Lau, W.; Jones, A.J.

How can we improve the translational landscape for a faster cure of type 1 diabetes? Journal of Clinical Investigation, 2009, ISSN: 0021-9738

vonHerrath, M.; Chan, A.C.

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice Journal of Clinical Investigation, 2009, ISSN: 1558-8238

Qing, J.; Du, X.; Chen, Y.M.; Chan, P.; Li, H.; Wu, P.; Marsters, S.; Stawicki, S.; Tien, J.; Totpal, K.; Ross, S.; Stinson, S.; Dornan, D.; French, D.; Wang, Q.; Stephan, J.P.; Wu, Y.; Wiesmann, C.; Ashkenazi, A.

View on PubMed
The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development, 2009, ISSN: 0950-1991

Eshkar-Oren, I.; Viukov, S.V.; Salameh, S.; Krief, S.; Oh, C.D.; Akiyama, H.; Gerber, H.P.; Ferrara, N.; Zelzer, E.

The art of making an exit. Science, 2009, ISSN: 1095-9203

Carlsson, F.; Brown, E.J.

Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as a first-line treatment of metastatic colorectal cancer: results of the TREE study Journal of Clinical Oncology, 2008, ISSN: 0732-183X

Hochster, H.S.; Hart, L.L.; Ramanathan, R.K.; Childs, B.H.; Hainsworth, J.D.; Cohn, A.L.; Wong, L.; Fehrenbacher, L.; Abubakr, Y.; Saif, M.W.; Schwartzberg, L.; Hedrick, E.

Role of P-glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents. Drug Metabolism and Disposition, 2008, ISSN: 0090-9556

Garner, C.E.; Solon, E.; Lai, C.-M.; Lin, J.; Luo, G.; Jones, K.; Duan, J.; Decicco, C.P.; Maduskuie, T.; Mercer, S.E.; Gan, L.-S.; Qian, M.; Prakash, S.; Shen, H.-S.; Lee, F.W.

Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chemical Biology, 2009, ISSN: 1552-4469

Zhang, Y.; Appleton, B.A.; Wiesmann, C.; Lau, T.; Costa, M.; Hannoush, R.N.; Sidhu, S.S.

Death receptor signal transducers: nodes of coordination in immune signaling networks Nature Immunology, 2009, ISSN: 1529-2916

Wilson, N.S.; Dixit, V.; Ashkenazi, A.

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis Journal of Cell Biology, 2009, ISSN: 0021-9525

Mao, Y.S.; Yamaga, M.; Zhu, X.; Wei, Y.J.; Sun, H.Q.; Wang, J.; Yun, M.; Wang, Y.F.; Di Paolo, G.; Bennett, M.; Mellman, I.; Abrams, C.S.; De Camilli, P.; Lu, C.Y.; Yin, H.L.

Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population Arthritis & Rheumatism, 2009, ISSN: 0004-3591

Ito, I.; Kawasaki, A.; Ito, S.; Hayashi, T.; Goto, D.; Matsumoto, I.; Tsutsumi, A.; Hom, G.; Graham, R.R.; Takasaki, Y.; Hashimoto, H.; Ohashi, J.; Behrens, T.W.; Sumida, T.;Tsuchiya, N.

Genetic deletion of JAM-C reveals a role in myeloid progenitor generation. Blood, 2009, ISSN: 1528-0020

Praetor, A,; McBride, J.M,; Chiu, H.; Rangell, L.; Cabote, L.; Lee, W.P.; Cupp, J.; Danilenko, D.M.; Fong, S.

A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation Analytical Biochemistry, 2009, ISSN: 1096-0309

Demeule, B.; Shire, S.; Liu, J.

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site Science, 2009, ISSN: 0036-8075

Bostrom, J.; Yu, S.-F.; Kan, D.; Appleton, B.A.; Lee, C.V.; Billeci, K.; Man, W.; Peale, F.; Ross, S.; Wiesmann, C.; Fuh, G.

Fatal hepatitis mediated by tumor necrosis factor TNFα requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity, 2009, ISSN: 1074-7613

Kaufmann, T.; Jost, P.J.; Pellegrini, M.; Puthalakath, H.; Gugasyan, R.; Gerondakis, S.; Cretney, E.; Smyth, M.J.; Silke, J.; Hakem, R.; Bouillet, P.; Mak, T.W.; Dixit, V.M.; Strasser A.

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature, 2009, ISSN: 0028-0836

Nikolaev, A.; McLaughlin, T.; O'Leary, D.D.M.; Tessier-Lavigne, M.

GPS navigation of the protein-stability landscape. Nature Biotechnology, 2009, ISSN: 1087-0156

Kirkpatrick, D.S.; Dixit, V.M.

Polar localization of virulence-related Esx-1 secretion in mycobacteria. PLoS Pathogens, 2009, ISSN: 1553-7374

Carlsson, F.; Joshi, S.A.; Rangell, L.; Brown, E.J.

Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Katschke, K.J., Jr.; Stawicki, S.; Yin, J.; Steffek, M.; Xi, H.; Sturgeon, L.; Hass, P.E.; Loyet, K.; DeForge, L.; Wu, Y.; van Lookeren Campagne, M.; Wiesmann, C.

View on PubMed
Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials Journal of Clinical Oncology, 2009, ISSN: 0732-183X

Kabbinavar, F.F.; Hurwitz, H.I.; Yi, J.; Sarkar, S.; Rosen, O.

Distinct thresholds govern Myc's biological output In Vivo Cancer Cell, 2008, ISSN: 1535-6108

Murphy, D.J.; Junttila, M.R.; Pouyet, L.; Karnezis, A.; Shchors, K.; Bui, D.A.; Brown-Swigart, L.; Johnson, Leisa.; Evan, G.I.

Trace level analysis of leached Protein A in bioprocess samples without interference from the large excess of rhMAb IgG Journal of Immunological Methods, 2009, ISSN: 0022-1759

Zhu-Shimoni, J.; Gunawan, F.; Thomas, A.; Vanderlaan M.; Stults, J.

Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Elliott, J.M.; Rouge, L.; Wiesmann, C.; Scheer, J.M.

Automated de novo sequencing of monoclonal antibodies Nature Biotechnology, 2008, ISSN: 1087-0156

Bandeira, N.; Pham.V.; Pevzner, P.; Arnott, D.; Lill, J.R.

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood, 2009, ISSN: 0006-4971

Tiedt, R.; Coers, J.; Ziegler, S.; Wiestner, A.; Hao-Shen, H.; Bornmann, C.; Schenkel, J.; Karakhanova, S.; de Sauvage, F.J.; Jackson, C.W.; Skoda, R.C.

The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. Journal of Biological Chemistry, 2009, ISSN: 0021-9258

Li, W.; Danilenko, D.M.; Bunting, S.; Ganesan, R.; Sa, S.; Ferrando, R.; Wu, T.D.; Kolumam, G.A.; Ouyang, W.; Kirchhofer, D.

A specificity map for the PDZ domain family. PLoS Biology, 2008, ISSN: 1544-9173

Tonikian, R.; Zhang, Y.; Sazinsky, S.L.; Currell, B.; Yeh, J.-H.; Reva, B.; Held, H.A.; Appleton, B.A.; Evangelista, M.; Wu, Y.; Xin, X.; Chan, A.C.; Seshagiri, S.; Lasky, L.A.; Sander, C.; Boone, C.; Bader, G.D.; Sidhu S.S.

View on PubMed
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE) Journal of Clinical Oncology, 2008, ISSN: 0732-183X

Grothey, A.; Sugrue, M.M.; Purdie, D.M.; Dong, W.; Sargent, D.; Hedrick, E.; Kozloff, M.

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation Developmental Cell, 2008, ISSN: 1534-5807

Loktev, A.V.; Zhang, Q.; Beck, J.S.; Searby, C.C.; Scheetz, T.E.; Bazan, J.F.; Slusarski, D.C.; Sheffield, V.C.; Jackson, P.K.; Nachury, M.V.

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells Nature Immunology, 2009, ISSN: 1529-2908

Cupedo, T.; Crellin, N.K.; Papazian, N.; Rombouts, E.J.; Weijer, K.; Grogan, J.L.; Fibbe, W.E.; Cornelissen, J.J.; Spits, H.

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell, 2009, ISSN: 1535-6108

Crawford, Y.; Kasman, I.; Yu, L.; Zhong, C.; Wu, X.; Modrusan, Z.; Kaminker, J.; Ferrara, N.

Formation of the blood-brain barrier: Wnt signaling seals the deal. Journal of Cell Biology, 2008, ISSN: 1540-8140

Polakis, P.

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nature Immunology, 2009, ISSN: 1529-2916

Yu, X.; Harden, K.; Gonzalez, L.C.; Francesco, M.; Chiang, E.; Irving, B.; Tom, I.; Ivelja, S.; Refino, C.J.; Clark, H.; Eaton, D.; Grogan, J.L.

Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. Journal of Experimental Medicine, 2009, ISSN:

Goldszmid, R.S.; Coppens, I.; Lev, A.; Caspar, P.; Mellman, I.; Sher, A.

Generation of a prostate from a single adult stem cell Nature, 2008, ISSN: 0028-0836

Leong, Kevin; Wang, Bu-Er; Johnson, Leisa; Gao, Wei-Qiang

View on PubMed
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class IPI3 kinase for the treatment of cancer Journal of Medicinal Chemistry, 2008, ISSN: 0022-2623

Folkes, A.J.; Ahmadi, K.; Alderton, W.K.; Alix, S.; Baker, S.J.; Box, G.; Chuckowree, I.S.; Clarke, P.A.; Depledge, P.; Eccles, S.A.; Friedman, L.S.; Hayes, A.; Hancox, T.C.; Lensun, L.; Moore, P.; Olivero, A.G.; Pang, J.; Patel, S.; Pergl-Wilson, G.H.; Raynaud, F.I.; Robson, A.; Saghir, N.; Salphati, L.; Sohal, S.; Ultsch, M.H.; Wallweber, H.J.A.; Wiesmann, C.; et al;

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents Journal of Cell Biology, 2008, ISSN: 0021-9525

Degtyarev, Michael; Mazière, Ann De; Orr, Christine; Lin, Jie; Lee, Brian B.; Tien, Janet Y.; Prior, Wei W.; van Dijk, Suzanne; Wu, Hong; Gray, Daniel C.; Davis, David P.; Stern, Howard M.; Murray, Lesley J.; Hoeflich, Klaus P.; Klumperman, Judith; Friedman, Lori; Lin, Kui

View on PubMed
Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS ONE, 2008, ISSN:

Morrell, N.T.; Leucht, P.; Zhao, L.; Kim, J.-B.; ten Berge, D.; Ponnusamy, K.; Carre, A.L.; Dudek, H.; Zachlederova, M.; McElhaney, M.; Brunton, S.; Gunzner, J.; Callow, M.; Polakis, P.; Costa, M.; Zhang, X.M.; Helms, J.A.; Nusse R.;

The hunt for cyclin Cell, 2008, ISSN: 1097-4172

Jackson, P.K.

Stopping replication, at the beginning Nature Chemical Biology, 2008, ISSN: 1552-4450

Jackson, P.K.

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression Journal of Biological Chemistry, 2008, ISSN: 0021-9258

Tripathi, M.; Nandana, S.; Yamashita, H.; Ganesan, R.; Kirchhofer, D.; Quaranta, V.

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB Activation. Journal of Biological Chemistry, 2008, ISSN: 0021-9258

Varfolomeev, E.; Goncharov, T.; Fedorova, A.V.; Dynek, J.N.; Zobel, K.; Deshayes, K.; Fairbrother, W.J.; Vucic, D.

A paracrine requirement for hedgehog signalling in cancer. Nature, 2008, ISSN: 1476-4687

Yauch, R.L.; Gould, S.E.; Scales, S.J.; Tang, T.; Tian, H.; Ahn, C.P.; Marshall, D.; Fu, L.; Januario, T.; Kallop, D.; Nannini-Pepe, M.; Kotkow, K.; Marsters, J.C,; Rubin, L.L.; de Sauvage, F.J.;

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nature Genetics, 2008, ISSN: 1061-4036

Graham, R.R.; Cotsapas, C,; Davies, L.; Hackett, R.; Lessard, C.J.; Leon, .J.M.; Burtt, N,P.; Guiducci, C.; Parkin, M.; Gates, C.; Plenge, R.M.; Behrens, T.W.; Wither, J.E.; Rioux, J.D.; Fortin, P.R.; Graham, D.C.; Wong, A.K.; Vyse, T.J.; Daly, M.J.; Altshuler, D.; Moser, K.L.; Gaffney, P.M.

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus Nature Genetics, 2008, ISSN: 1061-4036

Musone, S.L.; Taylor, K.E.; Lu, T.T.; Nititham, J.; Ferreira, R.C.; Ortmann, W.; Shifrin, N.; Petri, M.A.; Kamboh, M.I.; Manzi, S.; Seldin, M.F.; Gregersen, P.K.; Behrens, T.W.; Ma, A.; Kwok, P.Y.; Criswell, L.A.

Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg Blood, 2008, ISSN: 0006-4971

Kim, D.D.; Miwa, T.; Kimura, Y.; Schwendener, R.A.; van Lookeren Campagne, M,V.; Song, W.C.

PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science, 2008, ISSN: 1095-9203

Atwal, J.K.; Pinkston-Gosse, J.; Syken, J.; Stawicki, S.; Wu, Y.; Shatz, C.; Tessier-Lavigne, M.

View on PubMed
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction Science Signaling, 2008, ISSN: 1937-9145

Evangelista, M.; Lim, T.Y.; Lee, J.; Parker, L.; Ashique, A.; Peterson, A.S.; Ye, W.; Davis, D.P.; de Sauvage, F.J.

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell, 2008, ISSN: 1097-4172

Newton, K; Matsumoto, M.L.; Wertz, I.E.; Kirkpatrick, D.S.; Lill, J.R.; Tan, J.; Dugger, D.; Gordon, N.; Sidhu, S.S,; Fellouse, F.A.; Komuves, L.; French, D.M.; Ferrando, R.E.; Lam, C.; Compaan, D.; Yu, C.; Bosanac, I.; Hymowitz, S.G.; Kelley, R.F.; Dixit, V.M.

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC. Molecular Cell, 2008, ISSN: 1097-2765

Summers, Matthew K; Pan, Borlan; Mukhyala, Kiran; Jackson, Peter K

View on PubMed
DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1 Cell, 2008, ISSN: 0092-8674

Ly, A.; Nikolaev, A.; Suresh, G.; Zheng, Y.F.; Tessier-Lavigne, M.; Stein, E.

Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). Journal of Clinical Oncology, 2008, ISSN: 1527-7755

Ashkenazi, A.; Holland, P.; Eckhardt, S.G.

The unique N-terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances spindle checkpoint regulation of the APC Molecular Cell, 2008, ISSN: 1097-4164

Summers, M.K.; Pan, B.; Mukhyalka, K.; Jackon, P.K.

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to late-stage autophagy inhibition Journal of Cell Biology, 2008, ISSN: 1540-8140

Degtyarev, M.; De Maziere, A.; Orr, C.; Lin, J.; Lee, B.B.; Tien, J.Y.; Prior, W.W.; van Dijk, S.; Wu, H.; Gray, D.C.; Davis, D.P.; Stern, H.M.; Murray, L.J.; Hoeflich, K.P.; Klumperman, J.; Friedman, L.S.; Lin, K.

A pentacyclic Aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of Medicinal Chemistry, 2008, ISSN: 1520-4804

Rawson, T.E.; Ruth, M.; Blackwood, E.; Burdick D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Georges, G.J.; Goller, B.; Halladay, J.; Hunsaker, T.; Kleinheinz, T.; Krell, H.-W.; Li, J.; Liang, J.; Limberg, A.; McNutt, A.; Moffat, J.; Phillips, G.; Ran, Y.; Safina, B.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhou, A.; Shu, B.-Y.; Ruger, P.; Cochran, A.G.

Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos Development, 2008, ISSN: 0950-1991

Jones, E.A.V.; Yuan, L.; Breant, C.; Watts, R.J.; Eichmann, A.

Bridging Toll-like- and B cell-receptor signaling: meet me at the autophagosome. Immunity, 2008, ISSN: 1074-7613

Monroe, J.G.; Keir, M.E.

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nature Biotechnology, 2008, ISSN: 1087-0156

Junutula, J.R.; Raab, H.; Clark, S.; Bhakta, S.; Leipold, D.D.; Weir, S.; Chen, Y.; Simpson, M.; Tsai, S.P.; Dennis, M.S.; Lu, Y.; Meng, G.; Ng, C.; Yang, J.; Lee, C.C.; Duenas, E.; Gorrell, J.; Katta, V.; Kim, A .; McDorman, K.; Flagella, K.; Venook, R.; Ross, S.; Spencer, S.D.; Wong, W.L.; Lowman, H.B.; Vandlen, R.; Sliwkowski, M.X.; Scheller, R.; Polakis, P.; Mallet, W.

View on PubMed
To kill a tumor cell: the potential of proapoptotic receptor agonists. Journal of Clinical Investigation, 2008, ISSN: 0021-9738

Ashkenazi, A.; Herbst, R.S.

Spinophilin participates in information transfer at immunological synapses Journal of Cell Biology, 2008, ISSN: 0021-9525

Bloom, O.; Unternaehrer, J.J.; Jiang, A,; Shin, J.S.; Delamarre, L.; Allen, P.; Mellman, I.

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I Nature Immunology, 2008, ISSN: 1529-2908

Di Pucchio, T,; Chatterjee, B.; Smed-Sorensen, A.; Clayton, S.; Palazzo, A.; Montes, M.; Xue, Y.; Mellman, I.; Banchereau, J.; Connolly, J.E.

Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay. Journal of Immunological Methods, 2008, ISSN: 0022-1759

Yang, J.; Ng, C.; Lowman, H.; Chestnut, R.; Schofield, C.; Sandlund, B.; Ernst, J.; Bennett, G.; Quarmby, V.

On-line CE-LIF-MS technology for the direct characterization of N-linked glycans from therapeutic antibodies. Analytical Chemistry, 2008, ISSN: 1520-6882

Gennaro, L.A.; Salas-Solano, O.

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron, 2008, ISSN: 1097-4199

Chen, Z.; Gore, B.B.; Long, H.; Ma, L.; Tessier-Lavigne, M.

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. Journal of Immunological Methods, 2008, ISSN: 0022-1759

Koren, E.; Smith, H.W.; Shores, E.; Shankar, G.; Finco-Kent, D.; Rup, B.; Barrett, Y.-C.; Devanarayan, V.; Gorovits, B.; Gupta, S.; Parish, T.; Quarmby, V.; Moxness, M.; Swanson, S.J.; Taniguchi, G.; Zuckerman, L.A.; Stebbins, C.C.; Mire-Sluis A.

Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling. PLoS ONE, 2008, ISSN: 1932-6203

Wang, B.-E.; Wang, X.-D.; Ernst, J.A.; Polakis, P.; Gao, W.-Q.

The biological functions of T helper 17 cell effector cytokines in inflammation Immunity, 2008, ISSN: 1074-7613

Ouyang, W.; Kolls, J.K.; Zheng, Y.

Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107 Journal of Clinical Oncology, 2008, ISSN: 0732-183X

Grothey, A.; Hedrick, E.E.; Mass, R.D.; Sarkar, S.; Suzuki, S.; Ramanathan, R.K.; Hurwitz, H.I.; Goldberg. R.M.; Sargent, D.J.

Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody. Analytical Chemistry, 2008, ISSN: 0003-2700

Zhang, B.; Yang, Y.; Yuk, I.; Pai, R.; McKay, P.; Eigenbrot, C.; Dennis, M.; Katta, V.; Francissen, K.C.

VEGF inhibition and renal thrombotic microangiopathy New England Journal of Medicine, 2008, ISSN: 0028-4793

Eremina, V,; Jefferson, .J.A.; Kowalewska, J.; Hochster, H.; Haas, M.; Weisstuch, J.; Richardson, C.; Kopp, J.B.; Kabir, M.G.; Backx, P.H.; Gerber, H.P.; Ferrara, N.; Barisoni, L.; Alpers, C.E.; Quaggin, S.E.

Comment on: The consensus coding sequences of human breast and colorectal cancers Science, 2007, ISSN:

Forrest, W.F.; Cavet, G.

Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study Journal of Clinical Oncology, 2008, ISSN: 0732-183X

Bender, J.L.G.; Adamson, P.C.; Reid, J.M.; Xu, L.; Baruchel, S.; Shaked, Y.; Kerbel, R.S.; Cooney-Qualter, E.M.; Stempak, D.; Chen, H.X.; Nelson, M.D.; Krailo, M.D.; Ingle, A.M.; Blaney, S.M.; Kandel, J.J.; Yamashiro, D.J.

Blocking neuropilin-2 function inhibits tumor cell metastasis Cancer Cell, 2008, ISSN: 1535-6108

Caunt, M.; Mak, J.; Liang, W-C.; Stawicki, S.; Pan, Q.; Tong, R.K.; Kowalski, J.; Ho, C.; Reslan, H.B.; Ross, J.; Berry, L.; Kasman, I.; Zlot, C.; Cheng, Z.; Le Couter, J.; Filvaroff, E.H.; Plowman, G.; Peale, F.; French, D.; Carano, R.; Koch, A.W.; Wu, Y.; Watts, R.J.; Tessier-Lavigne, M.; Bagri, A.

View on PubMed
In pursuit of a super producer- alternative paths to high producing recombinant mammalian cells Current Opinion in Biotechnology, 2007, ISSN:

Seth, G.; Charaniya, S.; Wlaschin, K.F.; Hu, W.-S.

A trigger squeezed. Structure, 2008, ISSN: 0969-2126

Eigenbrot C.

Long-term safety of recombinant human growth hormone in Turner syndrome. Journal of Clinical Endocrinology and Metabolism, 2008, ISSN: 0021-972X

Bolar, K.; Hoffman, A.R.; Maneatis, T.; Lippe, B.

Regulation of a late phase of T cell polarity and effector functions by Crtam Cell, 2008, ISSN: 1097-4172

Yeh, J.H.; Sidhu, S.S.; Chan, A.C.

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature Medicine, 2008, ISSN: 1546-170X

Zheng, Y.; Valdez, P.A.; Danilenko, D.M.; Hu, Y.; Sa, S.M.; Gong, Q.; Abbas, A.R.; Modrusan, Z.; Ghilardi, N.; de Sauvage, F.J.; Ouyang W.

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. New England Journal of Medicine, 2008, ISSN: 1533-4406

Hom, G.; Graham, R.R.; Modrek, B.; Taylor, K.E.; Ortmann, W.; Garnier, S.; Lee, A.T.; Chung, S.A.; Ferreira, R.C.; Pant, P.V.; Ballinger, D.G.; Kosoy, R.; Demirci, F.Y.; Kamboh, M.I.; Kao, A.H.; Tian, C.; Gunnarsson, I.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Petri, M.; Manzi, S.; Seldin, M.F.; Ronnblom, L.; Syvanen, A.C.; Criswell, L.A.; Gregersen, P.K.; Behrens, T.W.

Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target. Neuron, 2008, ISSN: 0896-6273

Gore, B.B.; Wong, K.G.; Tessier-Lavigne, M.

B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis New England Journal of Medicine, 2008, ISSN: 0028-4793

Hauser, S.L.; Waubant, E.; Arnold, D.L.; Vollmer, T.; Antel, J.; Fox, R.J.; Bar-Or, A.; Panzara, M.; Sarkar, N.; Agarwal, S.; Langer-Gould, A.; Smith, C.H.

Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-cell Lung Cancer Working Group: standardization for use in the clinical trial setting. Journal of Clinical Oncology, 2008, ISSN: 1527-7755

Eberhard, D.A.; Giaccone, G.; Johnson, B.E.; Non-Small Cell Lung Cancer Working Group

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. Journal of Biological Chemistry, 2008, ISSN: 0021-9258

Barthelemy, P.A.; Raab, H.; Appleton, B.A.; Bond, C.J.; Wu, P.; Wiesmann, C.; Sidhu, S.S.

In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis. Journal of Immunological Methods, 2008, ISSN: 0022-1759

Kanwar, B.; Gao, D.W.; Hwang, A.B.; Grenert, J.P.; Williams, S.P.; Franc, B.; McCune, J.M.

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior. Analytical Biochemistry, 2008, ISSN: 0003-2697

Quan, C.; Alcala, E.; Petkovska, I.; Matthews, D.; Canova-Davis, E.; Taticek, R.; Ma, S.

Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. Journal of Cell Biology, 2007, ISSN: 0021-9525

Sfakianos, J.; Togawa, A.; Maday, S.; Hull, M.; Pypaert, M.; Cantley, L.; Toomre, D.; Mellman, I.

Cell division, growth and death. Current Opinion in Cell Biology, 2007, ISSN: 0955-0674

Jackson, P.K.; Peters, J.-M.

Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer Journal of Clinical Oncology, 2007, ISSN: 0732-183X

Herbst, R.S.; O'Neill, V.J.; Fehrenbacher, L.; Belani, C.P.; Bonomi, P.D.; Hart, L.; Melnyk, O.; Ramies, D.; Lin, M.; Sandler, A.

Structural insight into distinct mechanisms of protease inhibition by antibodies. Proceedings of the National Academy of Sciences, 2007, ISSN: 1091-6490

Wu, Y.; Eigenbrot, C.; Liang, W.C.; Stawicki, S.; Shia, S.; Fan, B.; Ganesan, R.; Lipari, M.T.; Kirchhofer, D.

View on PubMed
Disruption of E-Cadherin-Mediated Adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity, 2007, ISSN: 1074-7613

Jiang, A.; Bloom, O.; Ono, S.; Cui, W.; Unternaehrer, J.; Jiang, S.; Whitney, J.A.; Connolly, J.; Banchereau, J.; Mellman, I.

IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell, 2007, ISSN: 0092-8674

Varfolomeev, E., Blankenship, J.W.; Wayson, S.M.; Fedorova, A.V.; Kayagaki, N.; Garg, P.; Zobel, K.; Dynek, J.N.; Elliott, L.O.; Wallweber, H.J.; Flygare, J.A.; Fairbrother, W.J.; Deshayes, K.; Dixit, V.M.; Vucic, D.

The genomic landscapes of human breast and colorectal cancers Science, 2007, ISSN: 0036-8075

Wood, L.D.; Parsons, D.W.; Jones, S.; Lin, J.; Sjoblom, T.; Leary, R.J.; Shen, D.; Boca, S.M.; Barber, T.; Ptak, J.; Silliman, N.; Szabo, S.; Dezso, Z.; Ustyanksky, J.; Nikolskaya, T.; Nikolsky, Y.; Karchin, R.; Wilson, P.A.; Kaminker, J.S.; Zhang, Z.; Croshaw, R.; Willis, J.; ... Kinzler, K.W.; Velculescu, V.E.; Vogelstein, B.

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding EMBO Journal, 2007, ISSN: 0261-4189

Appleton, B.A.; Wu, P.; Maloney, J.; Yin, J.; Liang, W.-C.; Stawicki, S.; Mortara, K.; Bowman, K.K.; Elliott, J.M.; Desmarais, W.; Bazan, J.F.; Bagri, A.; Tessier-Lavigne, M.; Koch, A.W.; Wu, Y.; Watts, R.J.; Wiesmann, C.

View on PubMed
Tissue factor: A link between C5a and neutrophil activation in antiphospholipid antibody-induced fetal injury. Blood, 2007, ISSN: 0006-4971

Redecha, P.; Tilley, R.; Tencati, M.; Salmon, J.E.; Kirchhofer, D.; Mackman, N.; Girardi, G.

Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma Arthritis & Rheumatism, 2007, ISSN: 0004-3591

Sonnylal, S.; Denton, C.P.; Zheng, B.; Keene, D.R.; He, R.; Adams, H.P.; VanPelt, C.S.; Geng, Y.J.; Deng, J.M.; Behringer, R.R.; de Crombrugghe, B.

Randomized Phase II study of Erlotinib combined with Bevacizumab compared with Bevacizumab alone in matastatic renal cell cancer Journal of Clinical Oncology, 2007, ISSN: 0732-183X

Bukowski, R.M.; Kabbinavar, F.F.; Figlin, R.A.; Flaherty, K.; Srinivas, S.; Vaishampayan, U.; Drabkin, H.A.; Dutcher, J.; Ryba, S.; Xia, Q, ; Scappaticci, F.A.; McDermott, D.

Phage display for engineering and analyzing protein interaction interfaces Current Opinion in Structural Biology, 2007, ISSN: 0959-440X

Sidhu, S.S.; Koide, S.

Death receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL Nature Medicine, 2007, ISSN: 1078-8956

Wagner, K.W.; Punnoose, E.A.; Januario, T.; Lawrence, D.A.; Pitti, R.M.; Lancaster, K.; Lee, D.; Von Goetz, M.; Yee, S.F.; Totpal, K.; Huw, L.; Katta, V.; Cavet, G.; Hymowitz, S.G.; Amler, L.; Ashkenazi, A.

Bv8 regulates myeloid-cell-dependent tumour angiogenesis Nature, 2007, ISSN: 1476-4687

Shojaei, F.; Wu, X.; Zhong, C.; Yu, L.; Liang, X.H.; Yao, J.; Blanchard, D.; Bais, C.; Peale, F.V.; van Bruggen, N.; Ho, C.; Ross, J.; Tan, M.; Carano, R.A.; Meng, Y.G.; Ferrara. N.

Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkins's lymphoma xenografts Blood, 2007, ISSN: 0006-4971

Daniel, D.; Yang, B.; Lawrence, D.A.; Totpal, K.; Balter, I.; Lee, W.P.; Gogineni, A.; Cole, M.J.; Yee, S.F.; Ross, S.; Ashkenazi, A.

Metabolism, pharmacokinetics, and excretion of a nonpeptidic substance P receptor antagonist, ezlopitant, in normal healthy male volunteers: characterization of polar metabolites by chemical derivatization with dansyl chloride Drug Metabolism and Disposition, 2007, ISSN:

Prakash, C.; O'Donnell, J.; Khojasteh-Bakht, S.C.

Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade Blood, 2007, ISSN: 0006-4971

Lin Wei, Y.; Gong, Q.; Seshasayee, D.; Lin, Z.; Ou, Q.; Ye, S.; Suto, E.; Shu, J.; Lee, W.P.; Lee, C.V.; Fuh, G.; Leabman, M.; Iyer, S.; Howell, K.; Gelzleicher, T.; Beyer, J.; Danileko, D.; Yeh. S.; DeForge, L.E.; Ebens, A.; Thompson, J.S.; Ambrose, C.; Balazs, M.; Starovasnik, M.A.; Martin, F.

DUBA: a deubiquitinase that regulates type I interferon production Science, 2007, ISSN: 1095-9203

Kayagaki, N.; Phung, Q.; Chan, S.; Chaudhari, R.; Quan, C.; O'Rourke, K.; Eby, M.; Pietras, E.; Cheng, G.; Bazan, J.F.; Zhang, A.; Arnott, D.; Dixit, V.M.

Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer Journal of Clinical Oncology, 2007, ISSN: 0732-183X

Cannistra, S.A.; Matulonis, U.A.; Penson, R.T.; Hambleton, J.; Dupont, J.; Mackey, H.; Douglas, J.; Burger., R.A.; Armstrong, D.; Wenham, R.; McGuire, W.

Electrochemiluminescence to detect surface proteins on live cells Current Opinion in Pharmacology, 2007, ISSN: 1471-4892

Lu, Y.; Young, J.; Meng, Y.G.

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling Cell, 2007, ISSN: 0092-8674

Iwai, H.; Kim, M.; Yoshikawa, Y.; Ashida, H.; Ogawa, M.; Fujita, Y.; Muller, D.; Kirikae, T.; Jackson, P.K.; Kotani, S.; Sasakawa, C.

Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis Journal of Experimental Medicine, 2007, ISSN: 0022-1007

Anthoni, C.; Russell, J.; Wood, K.C.; Stokes, K.Y.; Vowinkel, T.; Kirchhofer, D.; Granger, D.N.

Autocrine VEGF signaling Is required for vascular homeostasis. Cell, 2007, ISSN: 0092-8674

Lee, S.; Chen, T.T.; Barber, C.L.; Jordan, M.C.; Murdock, J.; Desai, S.; Ferrara, N.; Nagy, A.; Roos, K.P.; Iruela-Arispe, M.L.

Liver-specific activities of FGF19 require Klotho beta. Journal of Biological Chemistry, 2007, ISSN: 0021-9258

Lin, B.C.; Wang, M.; Blackmore, C.; Desnoyers, L.R.

Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection. Nature Methods, 2007, ISSN: 1548-7091

Peters, B.A.; Kan, Z.; Sebisanovic, D.; Pujara, K.; Wang, Z.; Hong, P.; Chow, B.; Stinson, J.; Carlton, V.E.; Pham, T.Q.; Stern, H.; Waring, P.; Hillan, K.J.; Eberhard, D.A,; de Sauvage, F.; Zheng, J.; Faham, M.; Seshagiri, S.

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nature Biotechnology, 2007, ISSN: 1087-0156

Shojaei, F.; Wu, X.; Malik, A.K.; Zhong, C.; Baldwin, M.E.; Schanz, S.; Fuh, G.; Gerber, H.P.; Ferrara, N.

Private lives: reflections and challenges in understanding the cell biology of the immune system. Science, 2007, ISSN: 1095-9203

Mellman, I.

EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development, 2007, ISSN: 0950-1991

Schmidt, M.; Paes, K.; De Maziere, A.; Smyczek, T.; Yang, S.; Gray, A.; French, D.; Kasman, I.; Klumperman, J.; Rice, D.S.; Ye, W.

The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest Cell, 2007, ISSN: 0092-8674

Kaufmann, T.; Tai, L.; Ekert, P.G.; Huang, D.C.S.; Norris, F.; Lindemann, R.K.; Johnstone, R.W.; Dixit, V.M.; Strasser, A.

Exploring and designing protein function with restricted diversity Current Opinion in Chemical Biology, 2007, ISSN: 1367-5931

Sidhu, S.S.; Kossiakoff, A.A.

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection Nature Immunology, 2006, ISSN:

Zamboni, D.S.; Kobayashi, K.S.; Kohlsdorf, T.; Ogura, Y.; Long, E.M.; Vance, R.E., Kuida,K.; Mariathasan, S.; Dixit, V.M.; Flabell, R.A.; Dietrich, W.F.; Roy, C.R.

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. Journal of Experimental Medicine, 2007, ISSN: 0022-1007

Katschke, K.J. Jr.; Helmy, K.Y.; Steffek, M.; Xi, H.; Yin, J.; Lee, W.P.; Gribling, P.; Barck, K.H.; Carano, R.A.; Taylor, R.E.; Rangell, L.; Diehl, L.; Hass, P.E.; Wiesmann, C.; van Lookeren Campagne, M.

Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting Journal of Biological Chemistry, 2007, ISSN: 0021-9258

Pan, Q.; Chathery, Y.; Wu, Y.; Rathore, N.; Tong, R.K.; Peale, F.; Bagri, A.; Tessier-Lavigne, M.; Koch, A.W.; Watts, R.J.

View on PubMed
The vascular basement membrane: a niche for insulin gene expression and β cell proliferation Developmental Cell, 2006, ISSN:

Nikolova, G.; Jabs, N.; Konstantinova, I.; Domogatskaya, A.; Tryggvason, K.; Sorokin, L.; Fassler, R.; Gu, G.; Gerber, H.-P.; Ferrara, N.; Melton, D.A.; Lammert, E.

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma Blood, 2007, ISSN: 0006-4971

Polson, A.G.; Yu, S.-F.; Elkins, K.; Zheng, B.; Clark, S.; Ingle, G.S.; Slaga, D.S.; Giere, L.; Du, C.; Tan, C.; Hongo, J.; Gogineni, A.; Cole, M.J.; Vandlen, R.; Stephan, J.-P.; Young, J.; Chang, W.; Scales, S.J.; Ross, S.; Eaton, D.; Ebens, A.

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons Cell Metabolism, 2007, ISSN: 1550-4131

Beigneux, A.P.; Davies, B.S.J.; Gin, P.; Weinstein, M.M.; Farber, E.; Qiao, X.; Peale, F.; Bunting, S.; Walzem, R.L.; Wong, J.S.; Blaner, W.S.; Ding, Z.M.; Melford, K.; Wongsiriroj, N.; Shu, X.; de Sauvage, F.; Ryan, R.O.; Fong, L.G.; Bensadoun, A.; Young, S.G.

Full-length antibodies on display. Nature Biotechnology, 2007, ISSN: 1087-0156

Sidhu, S.S.

Vascular targeting via caveolae. Nature Biotechnology, 2007, ISSN: 1087-0156

Red-Horse, K.; Ferrara, N.

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell, 2007, ISSN:

Nachury, M.V.; Loktev, A.V.; Zhang, Q.; Westlake, C.J.; Peranen, J.; Merdes, A.; Slusarski, D.C.; Scheller, R.H.; Bazan, J.F.; Sheffield, V.C.; Jackson, P.K

Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy Journal of Clinical Oncology, 2007, ISSN: 0732-183X

Agus, D.B.; Sweeney, C.J.; Morris, M.J.; Mendelson, D.S.; McNeel, D.G.; Ahmann, F.R.; Wang. J.; Derynck, M.K.; Ng, K.; Lyons, B.; Allison, D.E.; Kattan, M.W.; Scher, H.I.

Ranibizumab for neovascular age-related macular degeneration - Reply New England Journal of Medicine, 2007, ISSN: 0028-4793

Rosenfeld, P.J.; Brown, D.M.; Schneider, S.

Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies Biochemistry, 2007, ISSN: 0006-2960

Wakankar, A.A.; Borchardt, R.T.; Eigenbrot, C.; Shia, S.; Wang, Y.J.; Shire, S.J.; Liu, J.L.

Ala 657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization Biochemistry, 2007, ISSN: 0006-2960

Meadows, S.A.; Edosada, C.Y.; Mayeda, M.; Tran, T.; Quan, C.; Raab, H.; Wiesmann, C.; Wolf, B.B.

Probing cellular systems with chemistry. Nature Chemical Biology, 2007, ISSN: 1552-4450

Hannoush, R.N.

Putting transcription repression and protein destruction in pRb's pocket. Developmental Cell, 2007, ISSN: 1534-5807

Verschuren, E.W.; Jackson, P.K.

Endothelium-microenvironment interactions in the developing embryo and in the adult. Developmental Cell, 2007, ISSN: 1534-5807

Red-Horse, K.; Crawford, Y.; Shojaei, F.; Ferrara, N.

Targeted therapy: wave of the future. Journal of Clinical Oncology, 2005, ISSN: 0732-183X

Pegram, M.D.; Pietras, R.; Bajamonde, A.; Klein, P.; Fyfe, G.

Natural killer or dendritic: what's in a name? Immunity, 2007, ISSN: 1074-7613

Spits, H.; Lanier, L.L.

The many ways of Wnt in cancer Current Opinion in Genetics & Development, 2007, ISSN: 0959-437X

Polakis, P.

Corneal avascularity is due to soluble VEGF receptor-1 Nature, 2006, ISSN:

Ambati, B.K.; Nozaki, M.; Singh, N.; Takeda, A.; Jani, P.D.; Suthar, T.; Albuquerque, R.J.C.; Richter, E.; Sakuri, E.;...Shibuya, M.; Baldwin, M.E.; Ferrara, N.; Gerber. H.-P.; De Falco, S.; Witta, J.; Baffi, J.Z.; Raisler, B.J.; Ambati, J.

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature, 2006, ISSN: 1476-4687

Ridgway, J .; Zhang, G.; Wu, Y.; Stawicki, S.; Liang, W.C.; Chanthery, Y.; Kowalski, J.; Watts, R.J.; Callahan, C.; Kasman, I.; Singh, M.; Chien, M.; Tan, C.; Hongo, J.A.; de Sauvage, F.; Plowman, G.; Yan, M.

View on PubMed
Challenges to the report of Nogo antibody effects in primates Nature Medicine, 2006, ISSN: 1078-8956

Ho, C.; Tessier-Lavigne, M.

Synthetic therapeutic antibodies Nature Chemical Biology, 2006, ISSN: 1552-4450

Sidhu, S.S.; Fellouse, F.A.

Boc is a receptor for sonic hedgehog in the guidance of commissural axons Nature, 2006, ISSN: 0028-0836

Okada, A.; Charron, F.; Morin, S.; Shin, D.S.; Wong, K.; Fabre, P.J.; Tessier-Lavigne, M.; McConnell, S.K.

Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest EMBO Journal, 2006, ISSN: 0261-4189

Kyei, G.B.; Vergne, I.; Chua, J.; Roberts, E.; Harris, J.; Junutula, J.R.; Deretic, V.

Interleuken-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology American Journal of Pathology, 2006, ISSN:

Rosas, L.E.; Satoskar, A.A.; Roth, K.M.; Keiser, T.L.; Barbi, J.; Hunter, C.; de Sauvage, F.J.; Satoskar, A.R.

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell, 2006, ISSN: 1535-6108

Pan, Q.; Chanthery, Y.; Liang, W.-C.; Stawicki, S.; Mak, J.; Pathore, N.; Tong, R.K.; Kowalski, J.; Yee, S.F.; Pacheco, G.; Ross, S.; Cheng, Z.; Le Couter, J.; Plowman, G.; Peale, F.; Koch, A.W.; Wu, Y.; Bagri, A.; Tessier-Lavigne, M.; Watts, R.

View on PubMed
Ranibizumab for neovascular age-related macular degeneration. New England Journal of Medicine, 2006, ISSN: 0028-4793

Rosenfeld, P.J.; Brown, D.M.; Heier, J.S.; Boyer, D.S.; Kaiser, P.K.; Chung, C.Y.; Kim, R.Y.

Ranibizumab versus verteporfin for neovascular age-related macular degeneration New England Journal of Medicine, 2006, ISSN: 0028-4793

Brown, D.M.; Kaiser, P.K.; Michels, M.; Soubrane, G.; Heier, J.S.; Kim, R.Y.; Sy, J.P.; Schneider, S.

Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature, 2006, ISSN: 0028-0836

Wiesmann, C.; Katschke, K.J., Jr.; Yin, J.P.; Helmy, K.Y.; Steffek, M.; Fairbrother, W.J.; McCallum, S.A.; Embuscado, L.; DeForge, L.; Hass, P.E.; van Lookeren Campagne, M.

Imaging tumor angiogenesis. Journal of Clinical Investigation, 2006, ISSN: 0021-9738

Red-Horse, K.; Ferrara, N.

Optimization and validation of a quantitative capillary electrophoresis sodium dodecyl sulfate method for quality control and stability monitoring of monoclonal antibodies. Analytical Chemistry, 2006, ISSN: 0003-2700

Salas-Solano, O.; Tomlinson, B.; Du, S.; Parker, M.; Strahan, A.; Ma, S.

The inhibitor of apoptosis protein fusion c-IAP2-MALT1 stimulates NF-κB activation independently of TRAF1 and TRAF2. Journal of Biological Chemistry, 2006, ISSN: 0021-9258

Varfolomeev, E.; Wayson, S.M.; Dixit, V.M.; Fairbrother, W.J.; Vucic, D.

A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection. Journal of Immunological Methods, 2006, ISSN: 0022-1759

Lu, Y.; Wong, W.L.; Meng, Y.G.

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly Biochemistry, 2006, ISSN: 0006-2960

McCallum, S.A.; Bazan, J.F.; Merchant, M.; Yin, J.; Pan, B.; de Sauvage, F.J.; Fairbrother, W.J.

Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. Journal of Biological Chemistry, 2006, ISSN: 0021-9258

Pal, G.; Kouadio, J.-L.; Artis, D.R.; Kossiakoff, A.A.; Sidhu, S.S.

Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1: Insights into determinants of PDZ domain specificity Journal of Biological Chemistry, 2006, ISSN: 0021-9258

Appleton, B.A.; Zhang, Y.; Wu, P.; Yin, J.P.; Hunziker, W.; Skelton, N.J.; Sidhu, S.S.; Wiesmann, C.

Convergent and divergent ligand specificity among PDZ domains of the LAP and Zonula Occludens (ZO) families. Journal of Biological Chemistry, 2006, ISSN: 0021-9258

Zhang, Y.; Yeh, S.; Appleton, B.A.; Held, H.A.; Kausalya, P.J.; Phua, D.C.; Wong, W.L.; Lasky, L.A.; Wiesmann, C.; Hunziker, W.; Sidhu, S.S.

The crystal structure of the costimulatory OX40-OX40L complex Structure, 2006, ISSN: 0969-2126

Compaan, D.M.; Hymowitz, S.G.

Metabolism, pharmacokinetics, tissue distribution, and excretion of [14C]CP-424391 in rats Drug Metabolism and Disposition, 2005, ISSN:

Khojasteh-Bakht, S.C.; O'Donnell, J.P.; Fouda, H.G.; Potchoiba, M.J.

Interleukin 27 limits autoimmune encephalomyelitis by suppressing develoment of interleukin 17-producing T cells Nature Immunology, 2006, ISSN: 1529-2908

Batten, M.; Li, J.; Yi, S.; Kljavin, N.M.; Danilenko, D.M.; Lucas, S.; Lee, J.; de Sauvage, F.J.; Ghilardi, N.

Capillary electrophoresis-mass spectrometry as a characterization tool for therapeutic proteins Analytical Biochemistry, 2006, ISSN: 0003-2697

Gennaro, L.A.; Salas-Solano, O.; Ma, S.

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Science, 2006, ISSN: 1095-9203

Dornan, D.; Shimizu, H.; Mah, A.; Dudhela, T.; Eby, M.; O'Rourke, K.; Seshagiri, S.; Dixit, V.

Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis Science, 2006, ISSN: 1095-9203

Foger, N.; Rangell, L.; Danilenko, D.M.; Chan, A.C.

Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis. Pharmaceutical Research, 2006, ISSN: 0724-8741

Ng, C.M.; Lum, B.L.; Gimenez, V.; Kelsey, S.; Allison, D.

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells Blood, 2006, ISSN: 0006-4971

Lee, C.V.; Hymowitz, S.G.; Wallweber, H.J.; Gordon, N.C.; Billeci, K.L.; Tsai, S.P.; Compaan, D.M.; Yin, J.; Gong, Q.; Kelley, R.F.; Deforge, L.E.; Martin, F.; Starovasnik, M.A.; Fuh, G.

MIG-10/lamellipodin and AGE-1/Pl3K promote axon guidance and outgrowth in response to slit and netrin Current Biology, 2006, ISSN: 0960-9822

Chang, C.; Adler, C.E.; Krause, M.; Clark, S.G.; Gertler F.B.; Tessier-Lavigne, M.; Bargmann, C.I.

De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand Analytical Biochemistry, 2006, ISSN: 0003-2697

Pham, V.; Henzel, W.J.; Arnott, D.; Hymowitz, S.; Sandoval, W.N.; Truong, B.-T.; Lowman, H.; Lill, J.R.

Differential reqirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 semaphorins Neuron, 2005, ISSN:

Yaron, A.;Huang, P.H.;Cheng, J.J.;Tessier-Lavigne, M.

Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance Development, 2005, ISSN:

Charron, F.;Tessier-Lavigne, M.

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell, 2006, ISSN:

Phillips, H.S.;Kharbanda, S.;Chen, R.;Forrest, W.F.;Soriano, R.H.;Wu, T.D.;Misra, A.;Nigro, J.M.;Colman, H.;Soroceanu, L.;Williams, P.M.;Modrusan, Z.;Feuerstein, B.G.;Aldape, K.

CRIg: A macriophage complement receptor required or phagocytosis of circulating pathogens Cell, 2006, ISSN:

Helmy, K.Y.;Katschke, K.J., Jr.;Gorgani, N.N.;Kljavin, N.M.;Elliott, J.M.;Diehl, L.;Scales, S.J.;Ghilardi, N.;van Lookeren Campagne, M.

The role of receptor internalization in CD95 signaling EMBO Journal, 2006, ISSN:

Lee, K.H.; Feig, C.; Tchikov, V.; Schickel, R.; Hallas, C.; Schutze, S.; Peter, M.E.; Chan, A.C.

Common mechanisms of nerve and blood vessel wiring Nature, 2005, ISSN:

Carmeliet, P.;Tessier-Lavigne, M.

Toward small-molecule agonists of TNF receptors Nature Chemical Biology, 2005, ISSN:

Hymowitz, S.G.;Ashkenazi, A.

Identification and immunotherapeutic targeting of antigens induced by chemotherapy Nature Biotechnology, 2006, ISSN:

Rubinfeld, B.;Upadhyay, A.;Clark, S.L.;Fong, S.E.;Smith, V.;Koeppen, H.;Ross, S.;Polakis, P.

EGFR activation mediates inhibition of axon regeneration by myelin inhibitors and chondroitin sulfate proteoglycans Science, 2005, ISSN:

Koprivica, V.;Cho, K.-S.;Park,J.B.;Yiu, G.;Atwal, J.;Gore, B.;Kim, J.A.;Lin, E.;Tessier-Lavigne, M.;Chen, D.F.;He, Z.

Cryopyrin activates the inflammasome in response to toxins and ATP Nature, 2006, ISSN: 0028-0836

Mariathasan, S.;Weiss, D.S.;Newton, K.;McBride, J.;O'Rourke, K.;Roos-Girma, M.;Lee, W.P.;Weinrauch, Y.;Monack, D.M.;Dixit, V.M.

When proteomes collide Science, 2006, ISSN:

Bader, J.S.;Chant, J.

Redundant roles of VEGF-B and PIGF during selective VEGF-A blockade in mice Blood, 2006, ISSN:

Malik, A.K.;Baldwin, M.E.;Peale, F.;Fuh, G.;Liang, W.C.;Lowman, H.;Meng, G.;Ferrara, N.;Gerber, H.P.

Angiogenesis as a therapeutic target Nature, 2005, ISSN:

Ferrara, N.;Kerbel, R.S.

TWEAK attenuates the transition from innate to adaptive immunity Cell, 2005, ISSN:

Maecker, H.;Varfolomeev, E.;Kischkel, F.;Lawrence, D.;Leblanc, H.;Lee, W.;Hurst, S.;Danilenko, D.;Li, J.;Filvaroff, E.;Yang, B.;Daniel, D.;Ashkenazi, A.

Pathogen recognition: TLRs throw us a curve Immunity, 2005, ISSN:

Kirk, P.;Bazan, J.F.

The crystal structure of the murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes Structure, 2006, ISSN:

Appleton, B.A.;Wu, P.;Wiesmann, C.

Regeneration of the adult central nervous system Current Biology, 2005, ISSN:

Case, L.C.;Tessier-Lavigne, M.

Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodyspastic syndrome Blood, 2005, ISSN:

Craven, S.E.;French, D.;Ye, W.;de Sauvage, F.;Rosenthal, A.

Isolation and characterization of the B-cell marker CD20 Biochemistry, 2005, ISSN:

Ernst, J.A.;Li, H.;Kim, H.S.;Nakamura, G.R.;Yansura, D.G.;Vandlen, R.L.

Pathogenic roles of B cells in human autoimmunity: insights from the clinic Immunity, 2004, ISSN:

Martin, F.;Chan, A.C.

Unraveling TACIt functions Nature Genetics, 2005, ISSN:

Martin, F.;Dixit, V.M.

Arming antibodies for cancer therapy Current Opinion in Pharmacology, 2005, ISSN:

Polakis, P.

A smooth operator for LPS responses Nature Immunology, 2005, ISSN:

Godowski, P.J.

Constitutive NF-κB activation by the t(11;18)(q21;q21) product in MALT lymhoma is linked to deregulated ubiquitin ligase activity Cancer Cell, 2005, ISSN:

Zhou, H.;Du, M.-Q.;Dixit, V.M.

Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback Development, 2005, ISSN:

Mukouyama, Y.S.;Gerber, H.P.;Ferrara, N.;Gu, C.;Anderson, D.J.

Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis Cancer Cell, 2004, ISSN:

Tang, N.;Wang, L.;Esko, J.;Giordano, F.J.;Huang, Y.;Gerber, H.-P.;Ferrara, N.;Johnson, R.S.

Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2 Science, 2004, ISSN:

Chen, W.;Ren, X.R.;Nelson, C.D.;Barak, L.S.;Chen, J.K.;Beachy, P.A.;de Sauvage, F.;Lefkowitz, R.J.

Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis Arthritis & Rheumatism, 2004, ISSN:

Barck, K.H.;Lee, W.P.;Diehl, L.J.;Ross, J.;Gribling, P.;Zhang, Y.;Nguyen, K.;van Bruggen, N.;Hurst, S.;Carano, R.A.D.

Production technologies for monoclonal antibodies and their fragments Current Opinion in Biotechnology, 2004, ISSN:

Andersen, D.;Reilly, D.E.

Activation and substrate specificity of caspase-14 Biochemistry, 2004, ISSN:

Miklolajczyk, J.;Scott, F.L.;Krajewski, S.;Sutherlin, D.P.;Salvesen, G.S.

Chemotkine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis Nature Medicine, 2004, ISSN:

Avecilla, S.T.;Hattori, K.;Heissig, B.;Tejada, R.;Liao, F.;Shido, K.;Jin, D.K.;Dias, S.;Zhang, F.;Hartman, T.E.;Hackett, N.R.;Crystal, R.G.;Witte, L.;Hicklin, D.J.;Bohlen, P.;Eaton, D.;Lyden, D.;de Sauvage, F.;Rafii, S.

The Sema domain of Met is necessary for receptor dimerization and activation Cancer Cell, 2004, ISSN:

Kong-Beltran, M.;Stamos, J.;Wickramasinghe, D.

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature, 2004, ISSN:

Mariathasan, S.;Newton, K.;Monack, D.M.;Vucic, D.;French, D.M.;Lee, W.P.;Roose-Girma, M.;Erickson, S.;Dixit, V.M.

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κ B signaling Nature, 2004, ISSN:

Wertz, I.E.;O'Rourke, K.M.;Zhou, H.;Eby, M.;Aravind, L.;Seshagiri, S.;Wu, P.;Wiesmann, C.;Baker, R.;Boone, D.L.;Ma, A.;Koonin, E.V.;Dixit, V.M.

Targeting death receptors in cancer with Apo2L/TRAIL Current Opinion in Pharmacology, 2004, ISSN:

Kelley, S.K.;Ashkenazi, A.

Convergent recognition of the IgE binding site on the high- affinity IgE receptor Structure, 2004, ISSN:

Stamos, J.;Eigenbrot, C.;Nakamura, G.;Reynolds, M.E.;Yin, J.;Lowman, H.B;Fairbrother, W.J;Starovasnik, M.A.

Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes Endocrinology, 2004, ISSN:

Fu, L.;John, L.M.;Adams, S.H.;Yu, X.X.;Tomlinson, E.;Renz, M.;Williams, P.M.;Soriano, R.;Corpuz, R.;Moffat, B.;Vandlen, R.;Simmons, L.;Foster, J.;Stephan, J.P.;Tsai, S.P.;Stewart, T.A.

The ubiquitin ligase COP1 is a critical negative regulator of p53 Nature, 2004, ISSN:

Dornan, D.;Wertz, I.;Shimizu, H.;Arnott, D.;Frantz, G.D.;Dowd, P.;O'Rourke, K.;Koeppen, H.;Dixit, V.M.

Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor EMBO Journal, 2004, ISSN: 0261-4189

Stamos, J.;Lazarus, R.A.;Yao, X.;Kirchhofer, D.;Wiesmann, C.

View on PubMed
Human de-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase Science, 2004, ISSN:

Wertz, I.E.;O'Rourke, K.M.;Zhang, Z.;Dornan, D.;Arnott, D.;Deshaies, R.J.;Dixit, V.M.

The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation Nature, 2004, ISSN:

Parker, L.H.;Schmidt, M.;Jin, S.W.;Gray, A.M.;Beis, D.;Pham, T.;Frantz, G.;Palmieri, S.;Hillan, K.;Stainier, D.Y.;de Sauvage, F.J.;Ye, W.

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex Cancer Cell, 2004, ISSN:

Franklin, M.C.;Carey, K.D.;Vajdos, F.F.;Leahy, D.J.;de Vos, A.M.;Sliwkowski, M.X.

Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells Blood, 2004, ISSN:

Hesser, B.A.;Liang, X.H.;Camenisch, G.;Yang, S.;Lewin, D.A.;Scheller, R.;Ferrara, N.;Gerber, H.P.

GATA2 specifies serotonergic nerurons downstream of sonic hedgehog Development, 2004, ISSN:

Craven, S.E.;Lim, K.C.;Ye, W.;Engel, J.D.;de Sauvage, F.;Rosenthal, A.

Tumor necrosis factor: an apoptosis JuNKie Cell, 2004, ISSN:

Varfolomeev, E.E.

Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity Biochemistry, 2004, ISSN:

Kelley, R.F.;Yang, J.;Eigenbrot, C.;Moran, P.;Peek, M.;Lipari, M.T.;Kirchhofer, D.

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells Science, 2004, ISSN:

Hasegawa, K.;Martin, F.;Huang, G.;Tumas, D.;Diehl, L.;Chan, A.C.

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO Nature, 2004, ISSN:

Zhou, H.;Wertz, I.;O'Rourke, K.;Ultsch, M.;Seshagiri, S.;Eby, M.;Xiao, W.;Dixit, V.M.