Man Wah Tan

Scientist, Infectious Diseases

POSTDOC MENTOR

• 3
  years at Genentech
• 7
  publications (2010-12)

My laboratory is interested in discovering and elucidating molecular mechanisms underlying bacterial pathogenesis and host responses within the context of an intact host. Using infection of C. elegans by bacterial pathogens, we have identified host and pathogen factors that contribute significantly to the outcome of an infection.

They include the involvements of the nervous system, the p38 mitogen-activated protein kinase and insulin signaling pathways of the host, as well as the quorum sensing system of the bacteria, in modulating host-pathogen interactions. We are now interested in validating and extending these findings in mammalian models of infections and in identifying critical nodes of interactions that are amenable to therapeutic interventions.

• My Focus

  Some projects in our laboratory involve the identification of genetic determinants from bacterial pathogens that are essential for pathogenesis and maintenance of infections in vivo using a combination of genetics, molecular and bioinformatics approaches, with focus on surface-associated molecules.

  We also seek to identify and characterize host factors that are associated with disease progression during infections. Our goals are to define bacterial and/or host factors these could potentially be targeted by small or large molecules for therapeutic interventions to ameliorate diseases, including pneumonia and bacteremia.

• Publications

  • Transforming the untransformable: Application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis

    mBio, 2012, ISSN:

    Monka, Ian R; Shahb, Ishita M; Xub, Min; Tanb, Man-Wah; Fostera, Timothy J;

     View on PubMed

  • The Two-Component Sensor Kinase KdpD is Required for Salmonella typhimurium Colonization of Caenorhabditis elegans and Survival in Macrophages

    Cellular microbiology, {Cell-Microbiol}, 25 Jul 2011 (epub: 25 7 2011), ISSN: 1462-5822.

    Alegado, Rosanna A; Chin, Chui Yoke; Monack, Denise M; Tan, Man Wah

     View on PubMed

  • Innate immunity: unfolding the neuro-immuno connections.

    Current biology : CB, {Curr-Biol}, 21 Jun 2011, vol. 21, no. 12, p. R474-6, ISSN: 1879-0445.

    Tan, Man Wah

     View on PubMed

  • Inaugural Article: Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.

    Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

    Kowanetz, M.; Wu, X.; Lee, J.; Tan, M.; Hagenbeek, T.; Qu, X.; Yu, L.; Ross, J.; Korsisaari, N.; Cao, T.; Bou, R.H.; Kallop, D.; Weimer, R.; Ludlam, M.J.; Kaminker, J.S.; Modrusan, Z.; van Bruggen, N.; Peale, F.V.; Carano, R.; Meng, Y.G.; Ferrara, N.

  • Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.

    Journal of Clinical Investigation, 2010, ISSN: 1558-8238

    Brightbill, H.; Jeet, S.; Lin, Z.; Yan, D.; Zhou, M.; Tan, M.; Nguyen, A.; Yeh, S.; Delarosa, D.; Leong, S.; Wong, T.; Chen, Y.; Ultsch, M.; Luis, E.; Ramani, S.; Jackman, J.; Gonzalez, L.; Dennis, M.; Chuntharapai, A.; DeForge, L.; Meng, Y.; Xu, M.; Eigenbrot, C.; Lee, W.; Refino, C.; Balazs, M.; Wu, L.

  • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models.

    Proc. Natl. Acad. Sci., USA, 2009, ISSN: 1091-6490

    Shojaei, F.; Wu, X.; Qu, X.; Kowanetz, M.; Yu, L.; Tan, M.; Meng, Y.G.; Ferrara, N.

  • Characterization and regulation of Bv8 in human blood cells.

    Clinical Cancer Research, 2009, ISSN: 1078-0432

    Zhong, C.; Qu, X.; Tan, M.; Meng, Y.G.; Ferrara, N.

• Education
  • Stanford University School of Medicine, Department of Genetics, Consulting Associate Professor – 2010
  • Stanford University School of Medicine, Department of Genetics, Assistant Professor – 2009
  • Harvard University and Massachusetts General Hospital, Harvard Junior Fellow – 2000
  • Harvard University, Ph.D. – 1997
  • Harvard University, A.M. – 1996
  • University of Cambridge, M.Phil. – 1987
  • Universiti Sains Malaysia, B.Sc. – 1986