Associate Director, Biomedical Imaging
"The beauty of optical imaging is the breadth of instrumentation and reporters that have been developed to enable visualization of structures from the cm to sub-micron range in vivo."
years at Genentech
awards & honors
I joined Genentech in 2006, and have been impressed with its collaborative environment, world-class science and continued focus on clinical questions. My lab collaborates across the research and early clinical development organizations. Our goal is to develop and implement imaging-based technologies to enable in vivo studies of disease biology and potential therapeutic approaches.
The postdoctoral program at Genentech provides a unique and exciting training opportunity. I am interested in understanding the mechanisms that regulate the stability of neuronal synaptic connections in vivo. Postdoctoral projects within my lab are focused on understand cell intrinsic and extrinsic pathways that influence the stability of these connections both in naive and disease paradigms. We rely on morphological and functional 2-photon in vivo imaging paradigms in combination with molecular genetic manipulations to study the interplay between neurons and glia in regulating synaptic connectivity.
Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis
Gogineni, A., Caunt, M., Crow, A., Lee, C.V., Fuh, G., van Bruggen, N., Ye, W. and Weimer, R.M
View Abstract on Pubmed
My lab is focused on combining optical imaging technologies with cellular and molecular tools to study the pathophysiology of human disease in vivo. The beauty of optical imaging is the breadth of instrumentation and reporters that have been developed to enable visualization of structures from the cm to sub-micron range in vivo. We utilize bioluminescence imaging, planar near-infrared fluorescence imaging, optical coherence tomography and 2-photon microscopy to span this range of resolution. Our instrumentation base is supported by a growing list of probes and transgenic models that report aspects of animal physiology, disease pathology, and cellular physiology. Combined, we can examine cellular and sub-cellular behavior in conjunction with physiological readouts to better understand disease progression in vivo and assess mechanisms of action of potential therapeutics.
Activity-Induced Nr4a1 Regulates Spine Density and Distribution Pattern of Excitatory Synapses in Pyramidal NeuronsNeuron, 2014, ISSN: 0896-6273 View on PubMed
Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse ModelsJournal of neuroscience, 2014, ISSN: 0270-6474 View on PubMed
A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine modelsThe Journal of Neuroscience, 2014, ISSN: 0270-6474 View on PubMed
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variantsThe Journal of experimental medicine, 2014, ISSN: 0022-1007 View on PubMed
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degenerationJournal of Experimental Medicine, 2013, ISSN: 0022-1007 View on PubMed
An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteinsmAbs, 2013, ISSN: 1942-0862 View on PubMed
An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteinsmAbs, 2014, ISSN: 1942-0862 View on PubMed
Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary MetastasisPLoS ONE, 2013, ISSN: 1932-6203 View on PubMed
A caspase cascade regulating developmental axon degenerationJournal of Neuroscience, 2012, ISSN: 0270-6474 View on PubMed
Spatially coordinated kinase signaling regulates local axon degenerationJournal of Neuroscience, 2012, ISSN: 0270-6474 View on PubMed
An effector-reduced anti-β-amyloid (Aβ) antibody with unique Aβ binding properties promotes neuroprotection and glial engulfment of AβJournal of Neuroscience, 2012, ISSN: 0270-6474 View on PubMed
An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In VivoPloS ONE, 2012, View on PubMed
Death Receptors DR6 and TROY Regulate Brain Vascular DevelopmentDevelopmental cell, 2012, ISSN: 1534-5807
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies.Oncogene, 2010, ISSN: 1476-5594 View on PubMed
- University of Utah, Ph.D Biology – 2002
Awards & Honors
- Genentech Key Contributor Award – 2012
- Ruth L. Kirschstein National Research Service Award from the National Institutes of Health – 2005
- Poste Vert Fellowship from the Institut National de la Santé et de la Recherche Médicale – 2002
- The Riser Award for outstanding graduate research in the Department of Biology, University of Utah – 2002
- Senior of the Year Award from the Department of Microbiology, Molecular Biology and Biochemistry, Un – 1996