Scientists / Our Scientists

Xin Ye

Senior Principal Scientist, Discovery Oncology, Research Biology

Postdoc Mentor

Years at Genentech

Awards & Honors

I obtained my PhD from Johns Hopkins University School of Medicine, studying Frizzled signaling in retinal angiogenesis and kidney development with Jeremy Nathans. I then trained with Bob Weinberg as a postdoctoral fellow at Whitehead Institute/MIT. Using mouse genetic approaches, my work uncovered distinct roles of SLUG vs SNAIL EMT transcription factors in normal mammary stem cells versus breast cancer stem cells.

I joined the Department of Discovery Oncology as a scientist in 2017. My group is interested in developing new technologies and methods to dissect pre-existing and adaptive programs associated with responses versus resistance to targeted therapies. We hope such knowledge will facilitate our drug discovery efforts and rational designs of drug combinations.

Postdoctoral Mentor

Postdocs bring fresh ideas to our research community and the postdoc program provides groups like mine a valuable opportunity to pursue important research questions related to our drug targets. I am honored to be part of this top-class program and look forward to mentoring future generations of scientists and growing my science with them.

Featured Publication

Identifying transcriptional programs underlying cancer drug response with TraCe-seq;

Nature Biotechnology; 2021

Chang, M.T., Shanahan, F., Nguyen, T.T.T., Staben, S.T., Gazzard, L., Yamazoe, S., Wertz, I.E., Piskol, R., Yang, A., Modrusan, Z., Haley, B., Evangelista, E., Malek, S., Foster, S.A., Ye, X.

View Abstract

Targeted therapies have demonstrated significant clinical benefits in many cancer patients. We believe that a deep understanding of the mechanisms underlying therapeutic responses versus resistance will spur the development of newer therapeutic approaches. We are particularly interested in dissecting the pre-existing and adaptive transcriptional programs that drive therapy resistance by leveraging and developing single cell and genomics approaches.

Whitehead Institute, MIT, Postdoctoral Fellow – 2017
The Johns Hopkins University School of Medicine, Ph.D. – 2010
Tsinghua University, Biological Sciences and Biotechnology, B.S. – 2004

Genentech Research and Innovation Fund – 2018, 2019
Cancer Prevention & Research Institute of Texas (CPRIT) Award (Declined) – 2016
Distinction in Teaching Award, Harvard University – 2016
NCI Pathway to Independence Award (K99) – 2015 - 2017
Helen Hay Whitney Postdoctoral Fellowship – 2010 - 2013
Damon Runyon Cancer Research Foundation Postdoctoral Research Fellowship Award (Declined) – 2010
The Martin and Carol Macht Award, Young Investigators’ Day Program, Johns Hopkins University School of Medicine – 2010
Tsinghua University Distinguished Scholarship – 2004

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Xin Ye

Senior Principal Scientist, Discovery Oncology, Research Biology

Featured Publication

Identifying transcriptional programs underlying cancer drug response with TraCe-seq;