Andrea Cochran - Principal Scientist, Early Discovery Biochemistry

Andrea Cochran

Principal Scientist, Early Discovery Biochemistry

Postdoc Mentor
"My long-term goal is to understand as much as possible about protein structure and function from a chemical perspective but more importantly, to apply this perspective to challenging biological problems."
Years at Genentech
Awards & Honors

I have been at Genentech since 1996. After training in chemical biology and in protein biophysics, I wanted to combine these fields. The Early Discovery Biochemistry department at Genentech is uniquely committed to investigating basic protein structure-function questions and, in particular, to understanding molecular recognition between proteins and between proteins and smaller molecules. We are especially interested in non-traditional therapeutic targets like protein-protein interactions. Projects in my lab involve diverse approaches to understanding proteins and protein complexes with the organizing theme of novel target or lead discovery in areas relevant to cancer. Our recent focus has been biochemistry of ubiquitin pathways and epigenetic regulation.

Postdoctoral Mentor

I enjoy hosting postdocs and students in my lab. It is great to see people develop as researchers, and the enthusiasm they bring to the lab keeps our work fun. Many of the key projects in the lab come from ideas contributed by students and postdocs, and this basic research benefits our efforts to discover novel targets and drugs.

Featured Publication

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase

Nature Communications, 2015, ISSN: 2041-1723

Taherbhoy, Asad M; Huang, Oscar W; Cochran, Andrea G