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Publications

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DISPLAYING 1 - 50 OF 14434 RESULTS

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
Nature Communications, ISSN: 20411723
Gerhardy; Ultsch; Wanjian Tang; Evan M. Green; Jeffrey K. Holden; Wei Li; Alberto Estevez; Christopher P. Arthur; Irene Tom; Alexis Rohou; Daniel Kirchhofer
View on Scopus
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Nature Communications,
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
View on Scopus
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors
Nature Communications, ISSN: 20411723
Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott E. Martin; Deepak Sampath; Kui Lin
View on Scopus
BMP1 is not required for lung fibrosis in mice
Scientific Reports, ISSN: 20452322
Hsiao-Yen Ma; Elsa-Noah N’Diaye; Patrick Caplazi; Zhiyu Huang; Alexander Arlantico; Surinc Er Jeet; Aaron Wong; Hans D. Brightbill; Qingling Li; Weng Wong; Wendy N. Sandoval; Lucinda Tam; Robert J. Newman; Merone Roose-Girma; Ning Ding
View on Scopus
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Nature Communications, ISSN: 20411723
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
View on Scopus
Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel
Nature Communications, ISSN: 20411723
Cameron Noland; Han Chow Chua; Marc Kschonsak; Stephanie Andrea Heusser; Nina Braun; Timothy Chang; Christine Tam; Jia Tang; Christopher P. Arthur; Claudio Ciferri; Stephan Alexander Pless; Jian Payandeh
View on Scopus
Prognostic mutational subtyping in de novo diffuse large B-cell lymphoma
BMC Cancer, ISSN: 14712407
Eugene Kim; Yanwen Jiang; Tao Xu; Alexandra Bazeos; Andrea Knapp; Christopher R. Bolen; Kathryn Humphrey; Tina Nielsen; Elicia M. Penuel; Joseph N. Paulson
View on Scopus
SM-Omics is an automated platform for high-throughput spatial multi-omics
Nature Communications, ISSN: 20411723
Sanja Vickovic; Britta Lötstedt; Johanna Klughammer; Mages; Asa Segerstolpe; Orit Rozenblatt-Rosen; Aviv Regev
View on Scopus
Structure of the core human NADPH oxidase NOX2
Nature Communications, ISSN: 20411723
Sigrid Noreng; Naruhisa Ota; Yonglian Sun; Hoangdung Ho; Matthew C. Johnson; Christopher P. Arthur; Kellen Schneider; Isabelle Lehoux; Christopher W. Davies; Kyle Mortara; Kit Wong; Dhaya Seshasayee; Matthieu Masureel; Jian Payandeh; Tangsheng Yi; James T. Koerber
View on Scopus
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Nature Communications, ISSN: 20411723
Yexuan Deng; Sarah T. Diepstraten; Margaret A. Potts; Göknur Giner; Stephanie Trezise; Ashley P. Ng; Gerry Healey; Serena R. Kane; Amali Cooray; Kira Behrens; Amy Heidersbach; Andrew J. Kueh; Martin Pal; Stephen Wilcox; Lin Tai; Warren S. Alexander; Jane E. Visvader; Stephen L. Nutt; Andreas Strasser; Benjamin Haley; Quan Zhao; Gemma L. Kelly; Herold
View on Scopus
Author Correction: Tumour gene expression signature in primary melanoma predicts long-term outcomes (Nature Communications, (2021), 12, 1, (1137), 10.1038/s41467-021-21207-2)
Nature Communications,
Manik Garg; Dominique-Laurent Couturier; Jérémie Nsengimana; Nuno A. Fonseca; Matthew Wongchenko; Yibing Yan; Martin Lauss; Göran B. Jönsson; Julia Newton-Bishop; Christine Parkinson; Mark R. Middleton; D. Timothy Bishop; Sarah McDonald; Nikki Stefanos; John Tadross; Ismael A. Vergara; Serigne Lo; Felicity Newell; James S. Wilmott; John F. Thompson; Georgina V. Long; Richard A. Scolyer; Pippa G. Corrie; David J. Adams; Alvis Brazma; Roy Rabbie
View on Scopus
Evaluation of statistical approaches for association testing in noisy drug screening data
BMC Bioinformatics,
Petr Smirnov; Ian Smith; Zhaleh Safikhani; Wail Ba-alawi; Farnoosh Khodakarami; Eva Lin; Yihong Yu; Scott E. Martin; Janosch Ortmann; Tero Aittokallio; Marc Hafner; Benjamin Haibe-Kains
View on Scopus
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer
Nature Communications, ISSN: 20411723
Johnson; Xueping Qu; Chu-Fang Lin; Huw; Avinashnarayan Venkatanarayan; Ethan S. Sokol; Fang-Shu Ou; Nnamdi Ihuegbu; Oliver A. Zill; Omar Kabbarah; Lisa I. Wang; Richard Bourgon; Felipe de Sousa e Melo; Christopher R. Bolen; Anneleen Daemen; Alan P. Venook; Federico Innocenti; Heinz-Josef Lenz; Carlos Bais
View on Scopus
Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (Nature Communications, (2022), 13, 1, (4739), 10.1038/s41467-022-32485-9)
Nature Communications, ISSN: 20411723
Yexuan Deng; Sarah T. Diepstraten; Margaret A. Potts; Göknur Giner; Stephanie Trezise; Ashley P. Ng; Gerry Healey; Serena R. Kane; Amali Cooray; Kira Behrens; Amy Heidersbach; Andrew J. Kueh; Martin Pal; Stephen Wilcox; Lin Tai; Warren S. Alexander; Jane E. Visvader; Stephen L. Nutt; Andreas Strasser; Benjamin Haley; Quan Zhao; Gemma L. Kelly; Herold
View on Scopus
Enzymatic basis of the Fc-selective intra-chain disulfide reduction and free thiol content variability in an antibody produced in Escherichia coli
Microbial Cell Factories, ISSN: 14752859
Tomasz K. Baginski; Karthik Veeravalli; Rebekah McKenna; Christopher Williams; Katherine Wong; Christina Tsai; Daniel Hewitt; Karthik Mani; Mike Laird
View on Scopus
Author Correction: Tumour gene expression signature in primary melanoma predicts long-term outcomes (Nature Communications, (2021), 12, 1, (1137), 10.1038/s41467-021-21207-2)
Nature Communications, ISSN: 20411723
Manik Garg; Dominique-Laurent Couturier; Jérémie Nsengimana; Nuno A. Fonseca; Matthew Wongchenko; Yibing Yan; Martin Lauss; Göran B. Jönsson; Julia Newton-Bishop; Christine Parkinson; Mark R. Middleton; D. Timothy Bishop; Sarah McDonald; Nikki Stefanos; John Tadross; Ismael A. Vergara; Serigne Lo; Felicity Newell; James S. Wilmott; John F. Thompson; Georgina V. Long; Richard A. Scolyer; Pippa G. Corrie; David J. Adams; Alvis Brazma; Roy Rabbie
View on Scopus
Long-term evaluation of the safety and efficacy of recombinant human pentraxin-2 (rhPTX-2) in patients with idiopathic pulmonary fibrosis (IPF): an open-label extension study
Respiratory Research, ISSN: 1465993X 14659921
Ganesh Raghu; Mark J. Hamblin; A. Whitney Brown; Jeffrey A. Golden; Lawrence A. Ho; Marlies S. Wijsenbeek; Martina Vašáková; Alberto Pesci; Danielle Antin-Ozerkis; Keith C. Meyer; Michael Kreuter; Tracy Burgess; Nikhil Kamath; Francis Donaldson; Luca Richeldi
View on Scopus
Evaluation of statistical approaches for association testing in noisy drug screening data
BMC Bioinformatics, ISSN: 14712105
Petr Smirnov; Ian Smith; Zhaleh Safikhani; Wail Ba-alawi; Farnoosh Khodakarami; Eva Lin; Yihong Yu; Scott E. Martin; Janosch Ortmann; Tero Aittokallio; Marc Hafner; Benjamin Haibe-Kains
View on Scopus
BMP1 is not required for lung fibrosis in mice
Scientific Reports, ISSN: 20452322
Hsiao-Yen Ma; Elsa-Noah N’Diaye; Patrick Caplazi; Zhiyu Huang; Alexander Arlantico; Surinc Er Jeet; Aaron Wong; Hans D. Brightbill; Qingling Li; Weng Ruth Wong; Wendy N. Sandoval; Lucinda Tam; Robert J. Newman; Merone Roose-Girma; Ning Ding
View on Scopus
A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk
Scientific Reports, ISSN: 20452322
Diana Chang; Julie Hunkapiller; Tushar Bhangale; Jens Reeder; Kiran Mukhyala; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Zia Khan; Amy Stockwell; Mark I. McCarthy; Tracy Staton; Julie Olsson; Cécile T.J. Holweg; Dorothy S. Cheung; Hubert Chen; Matthew J. Brauer; Robert R. Graham; Timothy Behrens; Mark S. Wilson; Joseph R. Arron; David F. Choy; Brian L. Yaspan
View on Scopus
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors
Nature Communications, ISSN: 20411723
Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott Martin; Deepak Sampath; Kui Lin
View on Scopus
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
Nature Communications,
Gurman Kaur; Caroline B. M. Porter; Orr Ashenberg; Jack Lee; Samantha J. Riesenfeld; Matan Hofree; Maria Aggelakopoulou; Ayshwarya Subramanian; Subita Balaram Kuttikkatte; Kathrine E. Attfield; Christiane Desel; Jessica L. Davies; Hayley G. Evans; Inbal Avraham-Davidi; Lan Nguyen; Danielle Dionne; Anna E. Neumann; Lise Torp Jensen; Thomas Barber; Elizabeth Soilleux; Mary Carrington; Gilean McVean; Orit Rozenblatt-Rosen; Aviv Regev; Lars Fugger
View on Scopus
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
Nature Communications,
Gerhardy; Ultsch; Wanjian Tang; Evan M. Green; Jeffrey K. Holden; Wei Li; Alberto Estevez; Christopher P. Arthur; Irene Tom; Alexis Rohou; Daniel Kirchhofer
View on Scopus
Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (Nature Communications, (2022), 13, 1, (4739), 10.1038/s41467-022-32485-9)
Nature Communications,
Yexuan Deng; Sarah T. Diepstraten; Margaret A. Potts; Göknur Giner; Stephanie Trezise; Ashley P. Ng; Gerry Healey; Serena R. Kane; Amali Cooray; Kira Behrens; Amy Heidersbach; Andrew J. Kueh; Martin Pal; Stephen Wilcox; Lin Tai; Warren S. Alexander; Jane E. Visvader; Stephen L. Nutt; Andreas Strasser; Benjamin Haley; Quan Zhao; Gemma L. Kelly; Herold
View on Scopus
Enzymatic basis of the Fc-selective intra-chain disulfide reduction and free thiol content variability in an antibody produced in Escherichia coli
Microbial Cell Factories,
Tomasz K. Baginski; Karthik Veeravalli; Rebekah McKenna; Christopher Williams; Katherine Wong; Christina Tsai; Daniel Hewitt; Karthik Mani; Mike Laird
View on Scopus
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer
Nature Communications,
Johnson; Xueping Qu; Chu-Fang Lin; Huw; Avinashnarayan Venkatanarayan; Ethan S. Sokol; Fang-Shu Ou; Nnamdi Ihuegbu; Oliver A. Zill; Omar Kabbarah; Lisa I. Wang; Richard Bourgon; Felipe de Sousa e Melo; Christopher R. Bolen; Anneleen Daemen; Alan P. Venook; Federico Innocenti; Heinz-Josef Lenz; Carlos Bais
View on Scopus
Long-term evaluation of the safety and efficacy of recombinant human pentraxin-2 (rhPTX-2) in patients with idiopathic pulmonary fibrosis (IPF): an open-label extension study
Respiratory Research, ISSN: 14659921
Ganesh Raghu; Mark J. Hamblin; A. Whitney Brown; Jeffrey A. Golden; Lawrence A. Ho; Marlies S. Wijsenbeek; Martina Vašáková; Alberto Pesci; Danielle Antin-Ozerkis; Keith C. Meyer; Michael Kreuter; Tracy Burgess; Nikhil Kamath; Francis Donaldson; Luca Richeldi
View on Scopus
Full automation of total metabolic tumor volume from FDG-PET/CT in DLBCL for baseline risk assessments
Cancer Imaging,
Skander Jemaa; Joseph N. Paulson; Hutchings; Lale Kostakoglu; Judith Trotman; Samuel Tracy; De Crespigny; Richard A. D. Carano; Tarec C. El-Galaly; Tina Nielsen; Thomas Bengtsson
View on Scopus
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
Nature Communications, ISSN: 20411723
Gurman Kaur; Caroline B. M. Porter; Orr Ashenberg; Jack Lee; Samantha J. Riesenfeld; Matan Hofree; Maria Aggelakopoulou; Ayshwarya Subramanian; Subita Balaram Kuttikkatte; Kathrine E. Attfield; Christiane Desel; Jessica L. Davies; Hayley G. Evans; Inbal Avraham-Davidi; Lan Nguyen; Danielle Dionne; Anna E. Neumann; Lise Torp Jensen; Thomas Barber; Elizabeth Soilleux; Mary Carrington; Gilean McVean; Orit Rozenblatt-Rosen; Aviv Regev; Lars Fugger
View on Scopus
BMP1 is not required for lung fibrosis in mice
Scientific Reports,
Hsiao-Yen Ma; Elsa-Noah N’Diaye; Patrick Caplazi; Zhiyu Huang; Alexander Arlantico; Surinc Er Jeet; Aaron Wong; Hans D. Brightbill; Qingling Li; Weng Ruth Wong; Wendy N. Sandoval; Lucinda Tam; Robert J. Newman; Merone Roose-Girma; Ning Ding
View on Scopus
A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk
Scientific Reports,
Diana Chang; Julie Hunkapiller; Tushar Bhangale; Jens Reeder; Kiran Mukhyala; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Zia Khan; Amy Stockwell; Mark I. McCarthy; Tracy Staton; Julie Olsson; Cécile T.J. Holweg; Dorothy S. Cheung; Hubert Chen; Matthew J. Brauer; Robert R. Graham; Timothy Behrens; Mark S. Wilson; Joseph R. Arron; David F. Choy; Brian L. Yaspan
View on Scopus
Heart and bladder detection and segmentation on FDG PET/CT by deep learning
BMC Medical Imaging, ISSN: 14712342
Xiaoyong Wang; Skander Jemaa; Jill Fredrickson; Alexandre Fernandez Coimbra; Tina Nielsen; De Crespigny; Thomas Bengtsson; Richard A. D. Carano
View on Scopus
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
Nature Communications, ISSN: 20411723
Fátima Cairrão; Cristiana C. Santos; Adrien Le Thomas; Scot A. Marsters; Avi Ashkenazi; Pedro M. Domingos
View on Scopus
Full automation of total metabolic tumor volume from FDG-PET/CT in DLBCL for baseline risk assessments
Cancer Imaging, ISSN: 14707330
Skander Jemaa; Joseph N. Paulson; Hutchings; Lale Kostakoglu; Judith Trotman; Samuel Tracy; De Crespigny; Richard A. D. Carano; Tarec C. El-Galaly; Tina Nielsen; Thomas Bengtsson
View on Scopus
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Nature Communications,
Yexuan Deng; Sarah T. Diepstraten; Margaret A. Potts; Göknur Giner; Stephanie Trezise; Ashley P. Ng; Gerry Healey; Serena R. Kane; Amali Cooray; Kira Behrens; Amy Heidersbach; Andrew J. Kueh; Martin Pal; Stephen Wilcox; Lin Tai; Warren S. Alexander; Jane E. Visvader; Stephen L. Nutt; Andreas Strasser; Benjamin Haley; Quan Zhao; Gemma L. Kelly; Herold
View on Scopus
Temporal Patterns and Adoption of Germline and Somatic BRCA Testing in Ovarian Cancer
Obstetrics and Gynecology, ISSN: 00297844
Sarah P. Huepenbecker; Jason D. Wright; Mary K. Downer; Devin Incerti; Patricia Luhn; Ignacio Dolado; Lydie Bastiere-Truchot; Yvonne G. Lin; John K. Chan; Larissa A. Meyer
View on Scopus
Extension of the Alternative Intravenous Dosing Regimens of Atezolizumab into Combination Settings through Modeling and Simulation
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Stephanie N. Liu; Mathilde Marchand; Xiaoyan Liu; Gladys Ingle; Maiya; Graupner; Markus C. Elze; Phyllis Chan; Joy C. Hsu; Alyse Lin; Shweta Vadhavkar; Benjamin Wu; Rene Bruno
View on Scopus
Temporal Patterns and Adoption of Germline and Somatic BRCA Testing in Ovarian Cancer
Obstetrics and Gynecology, ISSN: 1873233X 00297844
Sarah P. Huepenbecker; Jason D. Wright; Mary K. Downer; Devin Incerti; Patricia Luhn; Ignacio Dolado; Lydie Bastiere-Truchot; Yvonne G. Lin; John K. Chan; Larissa A. Meyer
View on Scopus
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers
Trends in Immunology, ISSN: 14714981 14714906
Sheena Pinto; Jens Pahl; Arndt J Schottelius; Paul J. Carter; Joachim Koch
View on Scopus
Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroid
Human Genetics, ISSN: 14321203 03406717
Jacqueline A. Piekos; Jacklyn N. Hellwege; Yanfei Zhang; Eric S. Torstenson; Gail P. Jarvik; Ozan Dikilitas; Iftikhar J. Kullo; Daniel J. Schaid; David R. Crosslin; Sarah A. Pendergrass; Ming Ta Michael Lee; Dan Roden; Joshua C. Denny; Todd L. Edwards; Digna R. Velez Edwards
View on Scopus
Clinical Pharmacology Perspectives for Adoptive Cell Therapies in Oncology
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Weize Huang; Junyi Li; Michael Z. Liao; Stephanie N. Liu; Jiajie Yu; Jing Jing; Naoki Kotani; Lynn Kamen; Sebastián Guelman; Dale Miles
View on Scopus
Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma
AAPS Journal, ISSN: 15507416
Hao Cai; Satoko Kakiuchi-Kiyota; Robert Hendricks; Shelly Zhong; Luna Liu; Adedeji; Pamela Chan; Melissa Schutten; Amrita Kamath; Meric A. Ovacik
View on Scopus
Management of Key Ocular Adverse Events in Patients Implanted with the Port Delivery System with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Carl C. Awh; Giulio Barteselli; Sneha Makadia; Robert T. Chang; Jay M. Stewart; Mark R. Wieland; Raymond Brassard; Natalia F. Callaway; Shamika Gune; Pam Heatherton; Varun Malhotra; Jeffrey R. Willis; Dante Joseph Pieramici
View on Scopus
Retrospective cohort study to assess the association between treatment with tocilizumab and mortality among mechanically ventilated patients with COVID-19
BMJ Open,
Jacek Skarbinski; Liyan Liu; Vennis Hong; Laura B. Amsden; Bruce H. Fireman; Vincent Yau; Devin Incerti; Lei Qian; Heidi Fischer; Bradley K. Ackerson; Sally F. Shaw; Sara Tartof
View on Scopus
Extending the performance of FcRn and FcγRIIIa affinity liquid chromatography for protein biopharmaceuticals
Journal of Chromatography A, ISSN: 18733778 00219673
Thomas Bouvarel; Bastiaan L. Duivelshof; Julien Camperi; Tilman Schlothauer; Alexander Knaupp; Cinzia Stella; Davy Guillarme
View on Scopus
Extending the performance of FcRn and FcγRIIIa affinity liquid chromatography for protein biopharmaceuticals
Journal of Chromatography A, ISSN: 00219673
Thomas Bouvarel; Bastiaan L. Duivelshof; Julien Camperi; Tilman Schlothauer; Alexander Knaupp; Cinzia Stella; Davy Guillarme
View on Scopus
Oxidative degradation in pharmaceuticals: Mechanism and stabilization of a spray-dried amorphous drug – A case study
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Raghavendhar R. Kotha; Kelly Zhang; Peter M. Yehl; Archana Kumar
View on Scopus
Oxidative degradation in pharmaceuticals: Mechanism and stabilization of a spray-dried amorphous drug – A case study
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Raghavendhar R. Kotha; Kelly Zhang; Peter M. Yehl; Archana Kumar
View on Scopus
Synthesis of 3-Aryl-Substituted 4-Aminopyrazoles from Acetophenones
Synthesis (Germany), ISSN: 1437210X 00397881
Andreas Stumpf; Di Xu; Tyler A. Tuck; Haiming Zhang
View on Scopus
C-H Activation by Isolable Cationic Bis(phosphine) Cobalt(III) Metallacycles
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
View on Scopus
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