Andrey Shaw

For 25 years, the major focus of my laboratory has been in signal transduction mechanisms with a major interest in protein kinases and pseudokinases. About 10% of the kinome are pseudokinases and we hypothesize that both pseudokinases and kinases have important non-catalytic functions. We hope that understanding the non-catalytic function of kinases and pseudokinases will lead to a better understanding of how they function and lead to insights into strategies to inhibit their function. We use a variety of tools including biochemistry, structural biology and mouse models to address these issues.

A second area of interest is using new imaging methods to visualize signaling processes in immune cells. Signal transduction is mainly studied biochemically as the average of thousands or millions of cells. We hope to interrogate signaling at the single cell level in vivo by developing mouse models that incorporate biosensors that would allow us to detect activation of multiple signaling events using state of the art, imaging techniques.

Lastly, because of a serendipitous finding in a knockout mouse, we have also had a serious interest in the molecular basis of chronic kidney diseases, a major unmet medical need. The ability to develop new treatments that ameliorate or attenuate kidney failure will require a better understanding of why and how kidneys fail. Our ideas include identifying genetic, environmental and cell biological triggers for cell death and injury in the kidney and developing methods/biomarkers for assessing kidney health and disease.

• Yale University, Post-doctoral Fellowship – 1991
• Yale New Haven Hospital, Anatomic Pathology Residency – 1986
• Columbia University College of Physicians and Surgeons, M.D. – 1984
• Columbia College, B.A. in music – 1979

• Alpha Omega Alpha – 2014
• Distinguished Investigator Award, Washington University, Washington University – 2012
• Kunkel Society – 2012
• AAAS Fellow – 2010
• American Association of Physicians – 2009
• NIH-NIAID Merit Award – 2005
• American Society of Clinical Investigation – 1999