Bob Lazarus

My lab works on fundamental and applied aspects of protein engineering in order to investigate molecular, biochemical and biological aspects of protein/protein and protein/ligand interactions. My goal is to understand biochemical and biological mechanisms and to develop specific agonists or antagonists as tools for specific intervention in the biological pathway of interest. I have particular interests in studying allosteric enzyme inhibitors and exosites as alternatives to traditional inhibitors and active sites.

General areas of interest include characterization of proteins involved in various pathways of cancer biology and inflammation, infectious disease, neurobiology, serine proteases and pseudo-proteases, deoxyribonucleases, and application of diversity technologies such as phage display. My lab utilizes peptides, proteins and protein scaffolds as molecular tools and various technologies to study these interactions. Some of the specific proteins of interest include Tryptase, HGF/Met, DNase I, BACE1, MSP/RON, Hedgehog/Hhip, and Factor VIIa.

• The Pennsylvania State University, Postdoctoral Research – 1979-1982
• The Pennsylvania State University, Ph. D. in Bioorganic Chemistry – 1979
• Lehigh University, B. S. in Chemistry – 1974

• President of the International Proteolysis Society – 2013
• Secretary of the International Proteolysis Society – 2011
• Lehigh University, Summa Cum Laude – 1974
• Lehigh University, Tau Beta Pi – 1974
• Lehigh University, Phi Beta Kappa – 1974